GLA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact6.94391535
2modulation by symbiont of host immune response (GO:0052553)6.94391535
3positive regulation by symbiont of host defense response (GO:0052509)6.94391535
4modulation by symbiont of host defense response (GO:0052031)6.94391535
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.94391535
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.94391535
7neutrophil activation involved in immune response (GO:0002283)5.43567425
8regulation of interferon-beta biosynthetic process (GO:0045357)5.32570809
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.31967349
10macrophage activation involved in immune response (GO:0002281)5.03556539
11positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.02840801
12response to peptidoglycan (GO:0032494)4.47620516
13positive regulation of interferon-alpha production (GO:0032727)4.39910521
14response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.36784883
15response to host immune response (GO:0052572)4.36784883
16respiratory burst (GO:0045730)4.32580695
17regulation of interferon-alpha production (GO:0032647)4.21861848
18negative regulation of mast cell activation (GO:0033004)4.20243751
19oligosaccharide catabolic process (GO:0009313)4.15508393
20microglial cell activation (GO:0001774)4.05321071
21immunoglobulin mediated immune response (GO:0016064)4.02959500
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.90193307
23response to host (GO:0075136)3.85220855
24response to host defenses (GO:0052200)3.85220855
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.85220855
26superoxide anion generation (GO:0042554)3.84458913
27natural killer cell mediated cytotoxicity (GO:0042267)3.83561405
28natural killer cell mediated immunity (GO:0002228)3.83561405
29positive regulation of interferon-beta production (GO:0032728)3.75526455
30macrophage activation (GO:0042116)3.73835594
31regulation of vitamin D biosynthetic process (GO:0060556)3.73439299
32* glycosphingolipid catabolic process (GO:0046479)3.69322126
33positive regulation of antigen processing and presentation (GO:0002579)3.66098714
34regulation of mononuclear cell migration (GO:0071675)3.64670028
35proteasome assembly (GO:0043248)3.64659360
36granulocyte activation (GO:0036230)3.62718531
37myeloid cell activation involved in immune response (GO:0002275)3.56940390
38regulation of mast cell degranulation (GO:0043304)3.51825392
39regulation of interleukin-8 biosynthetic process (GO:0045414)3.48962909
40neutrophil activation (GO:0042119)3.44987924
41positive regulation of chemokine biosynthetic process (GO:0045080)3.43055296
42purine nucleotide salvage (GO:0032261)3.41276543
43cellular response to arsenic-containing substance (GO:0071243)3.39533429
44regulation of mast cell activation involved in immune response (GO:0033006)3.35921806
45hydrogen peroxide biosynthetic process (GO:0050665)3.34344187
46regulation of mast cell activation (GO:0033003)3.34284773
47regulation of B cell receptor signaling pathway (GO:0050855)3.33822814
48regulation of antigen processing and presentation (GO:0002577)3.32736319
49* glycolipid catabolic process (GO:0019377)3.31423795
50lipopolysaccharide-mediated signaling pathway (GO:0031663)3.31138080
51neutrophil mediated immunity (GO:0002446)3.30752512
52detection of molecule of bacterial origin (GO:0032490)3.24007637
53regulation of podosome assembly (GO:0071801)3.20422453
54Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14737067
55regulation of chronic inflammatory response (GO:0002676)3.13899066
56reactive oxygen species biosynthetic process (GO:1903409)3.12498961
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08786283
58positive regulation of mast cell activation (GO:0033005)3.08247726
59leukocyte mediated cytotoxicity (GO:0001909)3.07081000
60production of molecular mediator involved in inflammatory response (GO:0002532)3.06890606
61response to muramyl dipeptide (GO:0032495)3.06850428
62phagosome maturation (GO:0090382)3.04439701
63B cell mediated immunity (GO:0019724)3.03986705
64pinocytosis (GO:0006907)3.00743214
65cellular response to thyroid hormone stimulus (GO:0097067)2.98961827
66negative regulation of ligase activity (GO:0051352)2.95244216
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95244216
68positive regulation of heat generation (GO:0031652)2.94946775
69protein neddylation (GO:0045116)2.92678452
70regulation of vitamin metabolic process (GO:0030656)2.92353486
71regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91695614
72regulation of interferon-beta production (GO:0032648)2.88577111
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.86877153
74regulation of leukocyte degranulation (GO:0043300)2.85773308
75negative regulation of interleukin-12 production (GO:0032695)2.84974502
76purine-containing compound salvage (GO:0043101)2.84952962
77amino sugar catabolic process (GO:0046348)2.83193224
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82141137
79positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.81906291
80* ceramide catabolic process (GO:0046514)2.81491970
81regulation of chemokine biosynthetic process (GO:0045073)2.80205120
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79677363
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78678639
84monocyte chemotaxis (GO:0002548)2.77468531
85positive regulation of T cell apoptotic process (GO:0070234)2.75759908
86intracellular pH reduction (GO:0051452)2.75435870
87positive regulation of lymphocyte apoptotic process (GO:0070230)2.75162189
88regulation of cytokine secretion involved in immune response (GO:0002739)2.75042194
89nucleobase-containing small molecule interconversion (GO:0015949)2.73382767
90positive regulation of chemokine production (GO:0032722)2.70769062
91positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.70441032
92regulation of fever generation (GO:0031620)2.70318015
93positive regulation of leukocyte apoptotic process (GO:2000108)2.70203976
94purine nucleobase biosynthetic process (GO:0009113)2.68992928
95regulation of superoxide anion generation (GO:0032928)2.68880568
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67307789
97cyclooxygenase pathway (GO:0019371)2.67107634
98negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.66887355
99eosinophil chemotaxis (GO:0048245)2.65431141
100lymphocyte mediated immunity (GO:0002449)2.64292155
101nucleotide salvage (GO:0043173)2.63632836
102positive regulation of mast cell activation involved in immune response (GO:0033008)2.62221082
103positive regulation of mast cell degranulation (GO:0043306)2.62221082
104regulation of myeloid leukocyte mediated immunity (GO:0002886)2.61922578
105* membrane lipid catabolic process (GO:0046466)2.61565291
106positive regulation of leukocyte degranulation (GO:0043302)2.59647455
107positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59589817
108I-kappaB phosphorylation (GO:0007252)2.58070512
109DNA strand elongation involved in DNA replication (GO:0006271)2.57620229
110protein maturation by protein folding (GO:0022417)2.57527009
111myeloid leukocyte activation (GO:0002274)2.57162238
112telomere maintenance via semi-conservative replication (GO:0032201)2.55204837
113wound healing, spreading of epidermal cells (GO:0035313)2.54276131
114cellular extravasation (GO:0045123)2.51862584
115* sphingolipid catabolic process (GO:0030149)2.51441300
116antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.50699983
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50457720
118regulation of cellular amino acid metabolic process (GO:0006521)2.49773883
119DNA strand elongation (GO:0022616)2.49017634
120sphingosine metabolic process (GO:0006670)2.48144196
121phagocytosis, recognition (GO:0006910)2.47765503
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.47651157
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.47651157
124hyaluronan catabolic process (GO:0030214)2.47052204
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.46837083
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.46837083
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.46837083
128nucleoside salvage (GO:0043174)2.45959551
129positive regulation of interleukin-6 production (GO:0032755)2.45798413
130actin nucleation (GO:0045010)2.45132351
131negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.44817295
132regulation of inflammatory response to antigenic stimulus (GO:0002861)2.44275056
133N-acetylneuraminate metabolic process (GO:0006054)2.44091838
134response to thyroid hormone (GO:0097066)2.43688644
135negative regulation of myeloid cell apoptotic process (GO:0033033)2.43532413
136positive regulation of monocyte chemotaxis (GO:0090026)2.43212372
137interferon-gamma-mediated signaling pathway (GO:0060333)2.41406200
138myeloid cell homeostasis (GO:0002262)2.40808614
139signal transduction involved in DNA integrity checkpoint (GO:0072401)2.40763977
140signal transduction involved in DNA damage checkpoint (GO:0072422)2.40763977
141leukocyte mediated immunity (GO:0002443)2.39222168
142positive regulation of toll-like receptor signaling pathway (GO:0034123)2.39108676
143positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.38305278
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.38246548
145negative regulation of interleukin-17 production (GO:0032700)2.37705601
146positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.37588217
147positive regulation of NF-kappaB import into nucleus (GO:0042346)2.36658133
148cytokine secretion (GO:0050663)2.36616682
149negative regulation of interleukin-6 production (GO:0032715)2.36400560
150folic acid-containing compound biosynthetic process (GO:0009396)2.35888720
151antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.35610608
152positive regulation of ligase activity (GO:0051351)2.34077427
153modulation of growth of symbiont involved in interaction with host (GO:0044144)2.32920660
154regulation of growth of symbiont in host (GO:0044126)2.32920660
155negative regulation of growth of symbiont in host (GO:0044130)2.32920660
156negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.32920660
157eosinophil migration (GO:0072677)2.32776603
158signal transduction involved in cell cycle checkpoint (GO:0072395)2.32654503
159IMP biosynthetic process (GO:0006188)2.31762233
160pentose metabolic process (GO:0019321)2.29504170
161regulation of T-helper 1 cell differentiation (GO:0045625)2.28788434
162NIK/NF-kappaB signaling (GO:0038061)2.28769884
163negative regulation of lipid storage (GO:0010888)2.26277045
164polyamine biosynthetic process (GO:0006596)2.23826438
165negative regulation of cytokine production involved in immune response (GO:0002719)2.22271456
166regulation of ubiquitin-protein transferase activity (GO:0051438)2.22111590
167lipoxygenase pathway (GO:0019372)2.21357156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.00480462
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.96848409
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.68649326
4E2F7_22180533_ChIP-Seq_HELA_Human4.23832830
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.75357206
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.59922776
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.41890307
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22952149
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.16755888
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91747965
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.87329081
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78883642
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57427753
14SPI1_23547873_ChIP-Seq_NB4_Human2.31931605
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.19612065
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18405453
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16666203
18TFEB_21752829_ChIP-Seq_HELA_Human2.11374662
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08882547
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02663404
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00264262
22BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99791250
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98286232
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89243269
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88158243
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87806098
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82048317
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.79331434
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78695052
30* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76201575
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75902423
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69810684
33* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67706398
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.62193607
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61483616
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61139018
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60928097
38PU_27001747_Chip-Seq_BMDM_Mouse1.59157827
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55612207
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55433515
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54659116
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54272008
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52527703
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51902418
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51856276
46* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50796949
47XRN2_22483619_ChIP-Seq_HELA_Human1.49417817
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.49339898
49GABP_19822575_ChIP-Seq_HepG2_Human1.47352705
50ELK1_19687146_ChIP-ChIP_HELA_Human1.46916781
51VDR_23849224_ChIP-Seq_CD4+_Human1.44276270
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43624565
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42924528
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39428365
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37543199
56MYB_26560356_Chip-Seq_TH2_Human1.32342218
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.32196062
58* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29514264
59VDR_24763502_ChIP-Seq_THP-1_Human1.28047474
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.27314040
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.26574160
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25576341
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.24701014
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23626758
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23223450
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22279640
67TTF2_22483619_ChIP-Seq_HELA_Human1.21662455
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20358449
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20158350
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19867925
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19861580
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19453797
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17879035
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17594399
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16269361
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16147001
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15854722
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15379377
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13965824
80MYB_26560356_Chip-Seq_TH1_Human1.12527936
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10674537
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10529039
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09647360
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09525921
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08999136
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08941021
87SPI1_23127762_ChIP-Seq_K562_Human1.08404200
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07770099
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07189945
90* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07125585
91DCP1A_22483619_ChIP-Seq_HELA_Human1.06545453
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05893729
93VDR_24787735_ChIP-Seq_THP-1_Human1.05857853
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05744467
95KDM5A_27292631_Chip-Seq_BREAST_Human1.04962113
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04229460
97ZNF263_19887448_ChIP-Seq_K562_Human1.04187264
98* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01392154
99VDR_21846776_ChIP-Seq_THP-1_Human1.01124902
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00855292
101* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99436698
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99048904
103* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98711766
104E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98432004
105FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98276925
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97187251
107MAF_26560356_Chip-Seq_TH1_Human0.95821651
108* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95720087
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95704247
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95701774
111YY1_21170310_ChIP-Seq_MESCs_Mouse0.95357595
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94743947
113GATA3_26560356_Chip-Seq_TH2_Human0.94252214
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94007447
115ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92698928
116E2F1_21310950_ChIP-Seq_MCF-7_Human0.92524706
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91948794
118MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90855341
119* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88438172
120NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86988691
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86300768
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.85149557
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84838830
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83707213
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82505334
126SRF_21415370_ChIP-Seq_HL-1_Mouse0.80990512
127AR_21909140_ChIP-Seq_LNCAP_Human0.80786567
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79583008
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79583008
130GATA3_27048872_Chip-Seq_THYMUS_Human0.79147348
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79068950
132FOXP3_21729870_ChIP-Seq_TREG_Human0.78368304
133MYCN_18555785_ChIP-Seq_MESCs_Mouse0.75717470

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.51340200
2MP0003806_abnormal_nucleotide_metabolis3.72639696
3MP0003303_peritoneal_inflammation3.56873366
4MP0001835_abnormal_antigen_presentation3.36291873
5MP0003436_decreased_susceptibility_to3.26066934
6MP0006082_CNS_inflammation3.05360272
7MP0002419_abnormal_innate_immunity2.99011502
8MP0003172_abnormal_lysosome_physiology2.96821448
9MP0005257_abnormal_intraocular_pressure2.67247497
10MP0005000_abnormal_immune_tolerance2.66177992
11MP0009785_altered_susceptibility_to2.58289372
12MP0002148_abnormal_hypersensitivity_rea2.56143651
13MP0000569_abnormal_digit_pigmentation2.38588230
14MP0002452_abnormal_antigen_presenting2.31541282
15MP0003724_increased_susceptibility_to2.30816988
16MP0005025_abnormal_response_to2.27661908
17MP0009840_abnormal_foam_cell2.22023721
18MP0010307_abnormal_tumor_latency2.20011387
19MP0002139_abnormal_hepatobiliary_system2.09688269
20MP0003448_altered_tumor_morphology2.08523475
21MP0001533_abnormal_skeleton_physiology2.03774208
22MP0002723_abnormal_immune_serum2.03766885
23MP0001790_abnormal_immune_system2.01534874
24MP0005387_immune_system_phenotype2.01534874
25MP0001800_abnormal_humoral_immune1.94953226
26MP0008260_abnormal_autophagy1.94756787
27MP0009333_abnormal_splenocyte_physiolog1.92770222
28MP0003693_abnormal_embryo_hatching1.88029936
29MP0005464_abnormal_platelet_physiology1.87143750
30MP0001819_abnormal_immune_cell1.86053987
31MP0002420_abnormal_adaptive_immunity1.84452297
32MP0008004_abnormal_stomach_pH1.83017894
33MP0004510_myositis1.77803858
34MP0005671_abnormal_response_to1.77493955
35MP0002405_respiratory_system_inflammati1.68689853
36MP0004947_skin_inflammation1.63270530
37MP0006054_spinal_hemorrhage1.62277444
38MP0002998_abnormal_bone_remodeling1.61731396
39MP0000015_abnormal_ear_pigmentation1.61027720
40MP0008438_abnormal_cutaneous_collagen1.59936154
41MP0001845_abnormal_inflammatory_respons1.58603614
42MP0005174_abnormal_tail_pigmentation1.55982002
43MP0005310_abnormal_salivary_gland1.55904563
44MP0001853_heart_inflammation1.55294715
45MP0000858_altered_metastatic_potential1.52091668
46MP0000343_altered_response_to1.48394401
47MP0000685_abnormal_immune_system1.45733464
48MP0000604_amyloidosis1.45143471
49MP0000716_abnormal_immune_system1.36465061
50MP0008469_abnormal_protein_level1.33910045
51MP0001542_abnormal_bone_strength1.31535236
52MP0006036_abnormal_mitochondrial_physio1.30789076
53MP0000689_abnormal_spleen_morphology1.28649255
54MP0002277_abnormal_respiratory_mucosa1.28194778
55MP0008007_abnormal_cellular_replicative1.27886392
56MP0003111_abnormal_nucleus_morphology1.26955531
57MP0009764_decreased_sensitivity_to1.23718636
58MP0002398_abnormal_bone_marrow1.23535148
59MP0005390_skeleton_phenotype1.23148410
60MP0005167_abnormal_blood-brain_barrier1.21936990
61MP0005165_increased_susceptibility_to1.19822081
62MP0001851_eye_inflammation1.15210390
63MP0003300_gastrointestinal_ulcer1.14943682
64MP0009278_abnormal_bone_marrow1.14643818
65MP0002722_abnormal_immune_system1.14189023
66MP0002429_abnormal_blood_cell1.13665239
67MP0010155_abnormal_intestine_physiology1.12037586
68MP0009763_increased_sensitivity_to1.11458017
69MP0001545_abnormal_hematopoietic_system1.07813698
70MP0005397_hematopoietic_system_phenotyp1.07813698
71MP0003077_abnormal_cell_cycle1.07443707
72MP0003186_abnormal_redox_activity1.06792861
73MP0003191_abnormal_cellular_cholesterol1.06347829
74MP0003828_pulmonary_edema1.06088161
75MP0000490_abnormal_crypts_of1.05869703
76MP0003690_abnormal_glial_cell1.05793533
77MP0002396_abnormal_hematopoietic_system1.04939533
78MP0002933_joint_inflammation1.01934541
79MP0009765_abnormal_xenobiotic_induced1.01726593
80MP0005164_abnormal_response_to1.00278518
81MP0000465_gastrointestinal_hemorrhage0.97621952
82MP0006035_abnormal_mitochondrial_morpho0.97174710
83MP0004782_abnormal_surfactant_physiolog0.96223142
84MP0005076_abnormal_cell_differentiation0.96065095
85MP0003183_abnormal_peptide_metabolism0.95884761
86MP0005166_decreased_susceptibility_to0.95858823
87MP0003195_calcinosis0.94830732
88MP0001958_emphysema0.94690297
89* MP0000358_abnormal_cell_content/0.94644328
90MP0003566_abnormal_cell_adhesion0.94042651
91MP0010352_gastrointestinal_tract_polyps0.93305645
92MP0008932_abnormal_embryonic_tissue0.92213825
93MP0001764_abnormal_homeostasis0.91433091
94MP0003075_altered_response_to0.89782140
95MP0000313_abnormal_cell_death0.89422119
96MP0005410_abnormal_fertilization0.89281209
97MP0002006_tumorigenesis0.88691515
98MP0002090_abnormal_vision0.88170611
99MP0005647_abnormal_sex_gland0.87666864
100MP0000371_diluted_coat_color0.87143799
101MP0002332_abnormal_exercise_endurance0.85312821
102MP0003795_abnormal_bone_structure0.84619026
103MP0004808_abnormal_hematopoietic_stem0.84187775
104MP0001727_abnormal_embryo_implantation0.82677572
105MP0003786_premature_aging0.80436094
106MP0004883_abnormal_blood_vessel0.79227175
107MP0008057_abnormal_DNA_replication0.78856974
108MP0003718_maternal_effect0.78434983
109MP0005319_abnormal_enzyme/_coenzyme0.78015432
110MP0003656_abnormal_erythrocyte_physiolo0.76552515
111MP0003453_abnormal_keratinocyte_physiol0.76409226
112MP0002019_abnormal_tumor_incidence0.75332776
113MP0008058_abnormal_DNA_repair0.73870118
114MP0004957_abnormal_blastocyst_morpholog0.72647382
115MP0002254_reproductive_system_inflammat0.71304039
116MP0002166_altered_tumor_susceptibility0.70163483
117MP0005023_abnormal_wound_healing0.70102250
118MP0010094_abnormal_chromosome_stability0.69620361
119MP0002837_dystrophic_cardiac_calcinosis0.68740409
120MP0005451_abnormal_body_composition0.68607812
121MP0005621_abnormal_cell_physiology0.67517762
122MP0005365_abnormal_bile_salt0.66921473
123MP0005197_abnormal_uvea_morphology0.66839695
124MP0010386_abnormal_urinary_bladder0.66037245
125MP0002877_abnormal_melanocyte_morpholog0.65360049
126MP0003091_abnormal_cell_migration0.65186819

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.45551261
2Eczematoid dermatitis (HP:0000976)6.02360433
3Increased cerebral lipofuscin (HP:0011813)5.89548402
4Vacuolated lymphocytes (HP:0001922)5.70525896
5Recurrent bacterial skin infections (HP:0005406)5.64908605
6Abnormality of macrophages (HP:0004311)5.53044484
7Increased neuronal autofluorescent lipopigment (HP:0002074)5.12441817
8Abnormality of glycolipid metabolism (HP:0010969)5.12272875
9Abnormality of liposaccharide metabolism (HP:0010968)5.12272875
10Abnormality of glycosphingolipid metabolism (HP:0004343)5.12272875
11Recurrent gram-negative bacterial infections (HP:0005420)4.99229103
12Dysostosis multiplex (HP:0000943)4.20907551
13Purpura (HP:0000979)3.93338639
14Disinhibition (HP:0000734)3.88097626
15Axonal loss (HP:0003447)3.82392152
16Prostate neoplasm (HP:0100787)3.67348221
17Stomatitis (HP:0010280)3.53964339
18Mediastinal lymphadenopathy (HP:0100721)3.53579088
19Systemic lupus erythematosus (HP:0002725)3.49935578
20Urinary glycosaminoglycan excretion (HP:0003541)3.43929099
21Mucopolysacchariduria (HP:0008155)3.43929099
22Agnosia (HP:0010524)3.43916881
23Gingivitis (HP:0000230)3.42434304
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.37041331
25Abnormality of polysaccharide metabolism (HP:0011012)3.37041331
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.37041331
27Recurrent skin infections (HP:0001581)3.36028188
28* Chronic obstructive pulmonary disease (HP:0006510)3.33181829
29* Obstructive lung disease (HP:0006536)3.33181829
30Myositis (HP:0100614)3.29578490
31Optic neuritis (HP:0100653)3.26451492
32Retrobulbar optic neuritis (HP:0100654)3.26451492
33Orchitis (HP:0100796)3.24806619
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.14091042
35Osteolytic defects of the phalanges of the hand (HP:0009771)3.02898736
36Osteolytic defects of the hand bones (HP:0009699)3.02898736
37Recurrent fungal infections (HP:0002841)3.02070695
38Hepatosplenomegaly (HP:0001433)3.00134392
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.00125065
40Vertebral compression fractures (HP:0002953)2.79470881
41Autoimmune thrombocytopenia (HP:0001973)2.78395062
42Increased serum ferritin (HP:0003281)2.77522444
43Basal ganglia calcification (HP:0002135)2.71188715
44Pustule (HP:0200039)2.66097864
45Loss of speech (HP:0002371)2.65149660
46Personality changes (HP:0000751)2.62310743
47Elevated erythrocyte sedimentation rate (HP:0003565)2.60187170
48Paralysis (HP:0003470)2.59793069
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57414793
50Acute necrotizing encephalopathy (HP:0006965)2.56682300
51Abnormal mitochondria in muscle tissue (HP:0008316)2.50670575
52Periodontitis (HP:0000704)2.49045812
53Eosinophilia (HP:0001880)2.47470238
54Leukocytosis (HP:0001974)2.47234131
55* Nausea (HP:0002018)2.45821870
563-Methylglutaconic aciduria (HP:0003535)2.44164322
57Tetraparesis (HP:0002273)2.44001308
58Nuclear cataract (HP:0100018)2.43385370
59Renal Fanconi syndrome (HP:0001994)2.42932745
60Multiple enchondromatosis (HP:0005701)2.42308553
61Abnormality of the anterior horn cell (HP:0006802)2.41875025
62Degeneration of anterior horn cells (HP:0002398)2.41875025
63Generalized aminoaciduria (HP:0002909)2.41441873
64Recurrent pneumonia (HP:0006532)2.38545582
65Petechiae (HP:0000967)2.37992705
66Interstitial pulmonary disease (HP:0006530)2.37747520
67Glomerulonephritis (HP:0000099)2.36801622
68Prolonged neonatal jaundice (HP:0006579)2.35322150
69Osteomyelitis (HP:0002754)2.35195456
70Prolonged bleeding time (HP:0003010)2.34416456
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.33628541
72Urticaria (HP:0001025)2.33327509
73Poor head control (HP:0002421)2.32861797
74Upper motor neuron abnormality (HP:0002127)2.32357601
75Abnormality of lateral ventricle (HP:0030047)2.30648353
76Thick nail (HP:0001805)2.29978903
77Metaphyseal irregularity (HP:0003025)2.27526240
78Mitochondrial inheritance (HP:0001427)2.26591246
79Abnormality of iron homeostasis (HP:0011031)2.25992221
80Recurrent cutaneous fungal infections (HP:0011370)2.25355588
81Chronic mucocutaneous candidiasis (HP:0002728)2.25355588
82Acute encephalopathy (HP:0006846)2.24016131
83Increased CSF lactate (HP:0002490)2.23908703
84J-shaped sella turcica (HP:0002680)2.22289896
85Cellulitis (HP:0100658)2.20302609
86Mutism (HP:0002300)2.19502665
87Recurrent viral infections (HP:0004429)2.18438202
88Bone pain (HP:0002653)2.17343357
89Pathologic fracture (HP:0002756)2.16630180
90Diminished motivation (HP:0000745)2.14420518
91Granulocytopenia (HP:0001913)2.12820924
92Submucous cleft hard palate (HP:0000176)2.10355879
93Abnormality of eosinophils (HP:0001879)2.09998501
94Type I transferrin isoform profile (HP:0003642)2.08168617
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07917057
96Vasculitis (HP:0002633)2.07352881
97Pulmonary infiltrates (HP:0002113)2.06787162
98Cervical subluxation (HP:0003308)2.06514915
99Premature rupture of membranes (HP:0001788)2.06492219
100Apathy (HP:0000741)2.05770827
101Increased IgM level (HP:0003496)2.04842927
102Increased mean platelet volume (HP:0011877)2.02828239
103Albinism (HP:0001022)2.01810583
104Recurrent lower respiratory tract infections (HP:0002783)2.01617734
105Peripheral demyelination (HP:0011096)2.01450282
106Abnormality of the prostate (HP:0008775)1.99052105
107Abnormal platelet volume (HP:0011876)1.96603407
108Segmental peripheral demyelination/remyelination (HP:0003481)1.95895910
109Progressive visual loss (HP:0000529)1.95452288
110Spondylolisthesis (HP:0003302)1.95317144
111Epistaxis (HP:0000421)1.95026633
112Cheilitis (HP:0100825)1.94369928
113Progressive macrocephaly (HP:0004481)1.94120359
114Esophageal neoplasm (HP:0100751)1.90955791
115Neoplasm of head and neck (HP:0012288)1.90955791
116Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90485256
117Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90485256
118Hepatocellular necrosis (HP:0001404)1.90197462
119Meningitis (HP:0001287)1.87304063
120Respiratory failure (HP:0002878)1.87095124
121Progressive neurologic deterioration (HP:0002344)1.85068327
122Abnormality of transition element cation homeostasis (HP:0011030)1.83667180
123Hepatic necrosis (HP:0002605)1.82730534
124Progressive muscle weakness (HP:0003323)1.82665087
125Ragged-red muscle fibers (HP:0003200)1.82318216
126Arterial thrombosis (HP:0004420)1.82012671
127Hypokinesia (HP:0002375)1.81958987
128Rough bone trabeculation (HP:0100670)1.81281830
129Microvesicular hepatic steatosis (HP:0001414)1.80032039
130Aseptic necrosis (HP:0010885)1.79493418
131* Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78586224
132Abnormal trabecular bone morphology (HP:0100671)1.77252542
133Increased serum lactate (HP:0002151)1.77139825
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76995474
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75916715
136Abnormal protein N-linked glycosylation (HP:0012347)1.75916715
137Abnormal protein glycosylation (HP:0012346)1.75916715
138Abnormal glycosylation (HP:0012345)1.75916715
139Hematochezia (HP:0002573)1.75374668
140Inappropriate behavior (HP:0000719)1.74645574
141Tinnitus (HP:0000360)1.74177575
142Lactic acidosis (HP:0003128)1.73915522
143Increased intramyocellular lipid droplets (HP:0012240)1.73801572
144Neuronal loss in central nervous system (HP:0002529)1.73667887
145Premature loss of primary teeth (HP:0006323)1.72989449
146Persistence of primary teeth (HP:0006335)1.70851056
147Entropion (HP:0000621)1.70230037
148Keratoconjunctivitis sicca (HP:0001097)1.66235196
149Global brain atrophy (HP:0002283)1.64740363
150Gingival bleeding (HP:0000225)1.64084597
151Neurodegeneration (HP:0002180)1.60606156
152Birth length less than 3rd percentile (HP:0003561)1.58856127

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.07968323
2IRAK43.29664361
3BLK3.22150750
4PBK3.16171644
5MAP3K142.95665290
6PDK22.94083818
7KIT2.54111193
8TBK12.53365394
9RIPK42.45832512
10BUB12.40928258
11TYK22.36509609
12IKBKB2.18655924
13EIF2AK12.17699008
14PIM22.07689959
15NME22.03315496
16GRK71.99589173
17NEK91.92516170
18PLK41.75708132
19ABL21.73389247
20MAP3K111.72809668
21IKBKE1.69199858
22WEE11.63473631
23ZAK1.62838251
24VRK21.62220086
25MAP4K11.53199171
26NEK11.49869645
27RPS6KA41.47850963
28EIF2AK31.46603711
29TAOK31.45372111
30CDC71.39334442
31ACVR1B1.39157688
32JAK11.37731211
33ZAP701.34420189
34TXK1.31466809
35EIF2AK21.31437170
36EPHA21.25918116
37JAK31.22907606
38PIM11.21392138
39TRIM281.17180400
40CHUK1.16028217
41CSF1R1.15383792
42SIK31.14165582
43LYN1.05934835
44EPHB11.05701528
45TEC1.04820369
46HCK1.04422559
47CSK0.99602048
48DDR20.99272957
49ADRBK20.99079124
50STK40.99072823
51STK100.96944342
52STK30.94964626
53MARK30.93035198
54DYRK30.92685194
55PAK40.92522636
56SYK0.90901919
57FES0.90404052
58FGR0.87900273
59LCK0.87847749
60MAP3K120.87802707
61SCYL20.86924816
62TAOK10.86510111
63BMPR20.83683735
64TESK20.83604214
65TESK10.83216065
66ERN10.81973871
67NEK20.81203798
68STK160.80892644
69MKNK10.78256631
70BCKDK0.76765191
71RPS6KA50.76139830
72SRPK10.75347255
73TGFBR20.73985341
74CSNK1G30.73623178
75CHEK20.70455882
76BMX0.69845614
77ALK0.69824938
78TLK10.68378915
79DAPK30.68016022
80YES10.67967950
81MAP2K30.67091377
82ABL10.66834852
83DAPK10.66777418
84TRPM70.65457981
85BRSK20.63731401
86TSSK60.63221160
87EPHA30.62611059
88PLK10.61544239
89PLK30.61530296
90KDR0.61417875
91PRKCD0.60686919
92AURKA0.60456338
93NUAK10.59258953
94MAP3K80.58593788
95CLK10.58499305
96IRAK10.58100979
97JAK20.56476696
98TTK0.55233011
99ARAF0.54509871
100MATK0.54123355
101MKNK20.53999349
102STK240.53944193
103TAOK20.52755374
104AKT30.52452919
105BTK0.51973976
106MAP3K50.51492697
107CAMKK20.50929583
108ILK0.50719363
109CSNK1A1L0.49615338
110ERBB30.48793433
111BMPR1B0.48722413
112CSNK2A10.47560216
113CDK70.44380152
114MAP3K130.44172639
115IRAK20.44149596
116EGFR0.43841747
117MOS0.43565866
118NME10.42853905
119MAPKAPK20.42638894
120ATR0.42116652
121VRK10.41527622
122BRAF0.41519124
123LIMK10.40910515
124MAP3K30.40637693
125AURKB0.40585687
126CCNB10.40281986
127CDK60.39427034
128ITK0.38516421
129FGFR30.37818577
130MAPKAPK30.36742290
131MST40.34476736
132PAK10.33933945
133CSNK1G20.33646803
134BRSK10.33402519

Predicted pathways (KEGG)

RankGene SetZ-score
1* Lysosome_Homo sapiens_hsa041423.28553007
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.09940463
3Leishmaniasis_Homo sapiens_hsa051402.77840919
4Other glycan degradation_Homo sapiens_hsa005112.44738286
5Rheumatoid arthritis_Homo sapiens_hsa053232.26744000
6Staphylococcus aureus infection_Homo sapiens_hsa051502.22991503
7Phagosome_Homo sapiens_hsa041452.18545545
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.15755682
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.15167008
10Osteoclast differentiation_Homo sapiens_hsa043802.10694764
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09906567
12Tuberculosis_Homo sapiens_hsa051522.08033654
13Oxidative phosphorylation_Homo sapiens_hsa001902.04348044
14Legionellosis_Homo sapiens_hsa051341.96451576
15Proteasome_Homo sapiens_hsa030501.86099731
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85654257
17Antigen processing and presentation_Homo sapiens_hsa046121.84986689
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78700176
19Malaria_Homo sapiens_hsa051441.77126781
20Pertussis_Homo sapiens_hsa051331.72087530
21Sulfur metabolism_Homo sapiens_hsa009201.71281030
22Parkinsons disease_Homo sapiens_hsa050121.58099637
23Measles_Homo sapiens_hsa051621.54637523
24Apoptosis_Homo sapiens_hsa042101.49527475
25Graft-versus-host disease_Homo sapiens_hsa053321.46412543
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44319759
27Glutathione metabolism_Homo sapiens_hsa004801.41546149
28Vitamin B6 metabolism_Homo sapiens_hsa007501.39273554
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38183404
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37629092
31Collecting duct acid secretion_Homo sapiens_hsa049661.37130218
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34872626
33Asthma_Homo sapiens_hsa053101.31039828
34Influenza A_Homo sapiens_hsa051641.29844607
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25990128
36RNA polymerase_Homo sapiens_hsa030201.24783740
37Salmonella infection_Homo sapiens_hsa051321.24212007
38TNF signaling pathway_Homo sapiens_hsa046681.23528015
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.23491169
40Herpes simplex infection_Homo sapiens_hsa051681.21307839
41Allograft rejection_Homo sapiens_hsa053301.21297321
42Hematopoietic cell lineage_Homo sapiens_hsa046401.18206226
43Shigellosis_Homo sapiens_hsa051311.16501377
44Epstein-Barr virus infection_Homo sapiens_hsa051691.12441584
45Toxoplasmosis_Homo sapiens_hsa051451.11827084
46Fatty acid elongation_Homo sapiens_hsa000621.11660133
47B cell receptor signaling pathway_Homo sapiens_hsa046621.10154812
48p53 signaling pathway_Homo sapiens_hsa041151.07504607
49Homologous recombination_Homo sapiens_hsa034401.06231941
50DNA replication_Homo sapiens_hsa030301.05827929
51Non-homologous end-joining_Homo sapiens_hsa034501.05652498
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05110491
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04059136
54Ribosome_Homo sapiens_hsa030101.03654602
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02764713
56* Sphingolipid metabolism_Homo sapiens_hsa006001.02092410
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00444859
58Hepatitis B_Homo sapiens_hsa051610.96831752
59Huntingtons disease_Homo sapiens_hsa050160.96043392
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95951136
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94884501
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88284498
63Bladder cancer_Homo sapiens_hsa052190.87349563
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.85361378
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83586358
66Alzheimers disease_Homo sapiens_hsa050100.83488931
67Mismatch repair_Homo sapiens_hsa034300.81534619
68Hepatitis C_Homo sapiens_hsa051600.80463257
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80085080
70Renin-angiotensin system_Homo sapiens_hsa046140.79041069
71RNA transport_Homo sapiens_hsa030130.77615423
72Chemokine signaling pathway_Homo sapiens_hsa040620.76423690
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76323620
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74350995
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73566783
76Viral carcinogenesis_Homo sapiens_hsa052030.72938260
77Cell cycle_Homo sapiens_hsa041100.72093627
78* Galactose metabolism_Homo sapiens_hsa000520.71851678
79Fanconi anemia pathway_Homo sapiens_hsa034600.71170858
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71098656
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.70320975
82* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69579156
83Pyrimidine metabolism_Homo sapiens_hsa002400.68950574
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.68319308
85Regulation of autophagy_Homo sapiens_hsa041400.68244587
86Purine metabolism_Homo sapiens_hsa002300.68038950
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67335660
88Protein export_Homo sapiens_hsa030600.67196661
89Fructose and mannose metabolism_Homo sapiens_hsa000510.64301169
90Nucleotide excision repair_Homo sapiens_hsa034200.64162609
91Steroid biosynthesis_Homo sapiens_hsa001000.61480572
92Pentose phosphate pathway_Homo sapiens_hsa000300.57897070
93Base excision repair_Homo sapiens_hsa034100.57873375
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57723875
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57089013
96Folate biosynthesis_Homo sapiens_hsa007900.56686766
97Amoebiasis_Homo sapiens_hsa051460.55338754
98Mineral absorption_Homo sapiens_hsa049780.55105913
99Chronic myeloid leukemia_Homo sapiens_hsa052200.54649744
100HIF-1 signaling pathway_Homo sapiens_hsa040660.53959198
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53548965
102African trypanosomiasis_Homo sapiens_hsa051430.53369761
103Basal transcription factors_Homo sapiens_hsa030220.50486587
104Vibrio cholerae infection_Homo sapiens_hsa051100.50180478
105Primary immunodeficiency_Homo sapiens_hsa053400.49439506
106Carbon metabolism_Homo sapiens_hsa012000.48516152
107Sulfur relay system_Homo sapiens_hsa041220.48507183
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.47819626
109Pancreatic cancer_Homo sapiens_hsa052120.47797805
110N-Glycan biosynthesis_Homo sapiens_hsa005100.47419215
111Small cell lung cancer_Homo sapiens_hsa052220.47000882
112T cell receptor signaling pathway_Homo sapiens_hsa046600.46513610
113Spliceosome_Homo sapiens_hsa030400.45341982
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45318539
115Endocytosis_Homo sapiens_hsa041440.45287588
116Autoimmune thyroid disease_Homo sapiens_hsa053200.44997275
117Type I diabetes mellitus_Homo sapiens_hsa049400.44807848
118MicroRNAs in cancer_Homo sapiens_hsa052060.43255754
119Acute myeloid leukemia_Homo sapiens_hsa052210.43236061
120Viral myocarditis_Homo sapiens_hsa054160.43172205
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.41208739
122Caffeine metabolism_Homo sapiens_hsa002320.40944867
123One carbon pool by folate_Homo sapiens_hsa006700.40192988
124Systemic lupus erythematosus_Homo sapiens_hsa053220.38793309
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.36135202

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