GLB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminal beta-linked galactose residue from ganglioside substrates and other glycoconjugates. Mutations in this gene may result in GM1-gangliosidosis and Morquio B syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oligosaccharide catabolic process (GO:0009313)5.02473411
2glycosphingolipid catabolic process (GO:0046479)4.75563774
3glycolipid catabolic process (GO:0019377)4.27391284
4ribosomal small subunit assembly (GO:0000028)4.18555709
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18296732
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18296732
7COPI coating of Golgi vesicle (GO:0048205)3.89246438
8Golgi transport vesicle coating (GO:0048200)3.89246438
9protein maturation by protein folding (GO:0022417)3.88470170
10mannose metabolic process (GO:0006013)3.85943763
11formation of translation preinitiation complex (GO:0001731)3.82293862
12ceramide catabolic process (GO:0046514)3.81593632
13antigen processing and presentation of endogenous antigen (GO:0019883)3.67667425
14cell adhesion mediated by integrin (GO:0033627)3.67548269
15regulation of interferon-beta biosynthetic process (GO:0045357)3.64760405
16hyaluronan catabolic process (GO:0030214)3.58803962
17antigen processing and presentation via MHC class Ib (GO:0002475)3.56899562
18regulation of cholesterol esterification (GO:0010872)3.55403209
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.54027268
20L-phenylalanine metabolic process (GO:0006558)3.54027268
21sphingolipid catabolic process (GO:0030149)3.53234137
22production of molecular mediator involved in inflammatory response (GO:0002532)3.45266028
23membrane lipid catabolic process (GO:0046466)3.44583908
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43496706
25amyloid precursor protein catabolic process (GO:0042987)3.40660887
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.36861075
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34619853
28nucleobase biosynthetic process (GO:0046112)3.30859382
29peptide catabolic process (GO:0043171)3.29273605
30protein retention in ER lumen (GO:0006621)3.28155780
31purine nucleobase biosynthetic process (GO:0009113)3.23875947
32Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20552362
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17114508
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16335209
35L-phenylalanine catabolic process (GO:0006559)3.16335209
36cellular copper ion homeostasis (GO:0006878)3.10723243
37skin morphogenesis (GO:0043589)3.10148068
38alpha-linolenic acid metabolic process (GO:0036109)3.04403865
39cholesterol efflux (GO:0033344)3.03885810
40signal peptide processing (GO:0006465)3.03785018
41glucose catabolic process (GO:0006007)3.01457338
42phospholipid efflux (GO:0033700)3.00007756
43peptidyl-glutamic acid carboxylation (GO:0017187)2.96018033
44protein carboxylation (GO:0018214)2.96018033
45positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.87716673
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87654620
47positive regulation by organism of defense response of other organism involved in symbiotic interact2.87654620
48modulation by symbiont of host immune response (GO:0052553)2.87654620
49positive regulation by symbiont of host defense response (GO:0052509)2.87654620
50modulation by symbiont of host defense response (GO:0052031)2.87654620
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87654620
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.86170145
53SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85952800
54toxin transport (GO:1901998)2.83068185
55plasma lipoprotein particle assembly (GO:0034377)2.82811199
56IMP biosynthetic process (GO:0006188)2.81830408
57very-low-density lipoprotein particle assembly (GO:0034379)2.81119499
58glucose 6-phosphate metabolic process (GO:0051156)2.79125592
59regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77734463
60regulation of mononuclear cell migration (GO:0071675)2.77195444
61protein targeting to ER (GO:0045047)2.76079774
62folic acid transport (GO:0015884)2.75291020
63DNA deamination (GO:0045006)2.74595275
64cotranslational protein targeting to membrane (GO:0006613)2.74013832
65immunoglobulin mediated immune response (GO:0016064)2.71702348
66folic acid metabolic process (GO:0046655)2.70870672
67viral transcription (GO:0019083)2.70286641
68folic acid-containing compound biosynthetic process (GO:0009396)2.70144212
69COPII vesicle coating (GO:0048208)2.68633165
70glycoside metabolic process (GO:0016137)2.68208001
71response to interferon-beta (GO:0035456)2.67997896
72maturation of SSU-rRNA (GO:0030490)2.67134116
73negative regulation of protein activation cascade (GO:2000258)2.66785032
74regulation of metalloenzyme activity (GO:0048552)2.65937663
75endosome to melanosome transport (GO:0035646)2.65205110
76endosome to pigment granule transport (GO:0043485)2.65205110
77positive regulation of interferon-alpha production (GO:0032727)2.64933396
78regulation of superoxide anion generation (GO:0032928)2.62382023
79translational termination (GO:0006415)2.61945291
80protein localization to endoplasmic reticulum (GO:0070972)2.61489397
81establishment of protein localization to endoplasmic reticulum (GO:0072599)2.61371243
82pinocytosis (GO:0006907)2.60853065
83sphingosine metabolic process (GO:0006670)2.60509060
84apoptotic cell clearance (GO:0043277)2.60384666
85* keratan sulfate catabolic process (GO:0042340)2.58265669
86plasma lipoprotein particle clearance (GO:0034381)2.58121916
87protein-lipid complex assembly (GO:0065005)2.57983081
88translational elongation (GO:0006414)2.57897686
89antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.57336043
90basement membrane organization (GO:0071711)2.55979705
91fibrinolysis (GO:0042730)2.55608628
92regulation of interferon-alpha production (GO:0032647)2.54043983
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52689762
94type B pancreatic cell proliferation (GO:0044342)2.52062415
95fat-soluble vitamin biosynthetic process (GO:0042362)2.50596289
96regulation of cytokine secretion involved in immune response (GO:0002739)2.50325881
97pentose-phosphate shunt (GO:0006098)2.49688078
98vesicle coating (GO:0006901)2.48372883
99regulation of protein activation cascade (GO:2000257)2.48349404
100IMP metabolic process (GO:0046040)2.48124828
101low-density lipoprotein particle clearance (GO:0034383)2.47640975
102neutrophil activation involved in immune response (GO:0002283)2.47372548
103regulation of integrin-mediated signaling pathway (GO:2001044)2.47246474
104positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.47213262
105barbed-end actin filament capping (GO:0051016)2.46750950
106chaperone mediated protein folding requiring cofactor (GO:0051085)2.46720870
107positive regulation of B cell differentiation (GO:0045579)2.46405541
108amino sugar catabolic process (GO:0046348)2.46298828
109DNA strand elongation involved in DNA replication (GO:0006271)2.45760166
110endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.45043159
111translational initiation (GO:0006413)2.44662949
112UDP-N-acetylglucosamine metabolic process (GO:0006047)2.43726467
113negative regulation of phagocytosis (GO:0050765)2.42462538
114membrane protein ectodomain proteolysis (GO:0006509)2.42449643
115adhesion of symbiont to host (GO:0044406)2.42379053
116amyloid precursor protein metabolic process (GO:0042982)2.41002125
117protein localization to endosome (GO:0036010)2.39901505
118membrane protein intracellular domain proteolysis (GO:0031293)2.39830711
119positive regulation of antigen processing and presentation (GO:0002579)2.39530760
120negative regulation of fibrinolysis (GO:0051918)2.39421154
121negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.38967115
122regulation of cholesterol storage (GO:0010885)2.38447058
123negative regulation of complement activation (GO:0045916)2.38321170
124cellular response to interferon-beta (GO:0035458)2.37989736
125B cell mediated immunity (GO:0019724)2.37815984
126substrate-dependent cell migration (GO:0006929)2.37600499
127regulation of complement activation (GO:0030449)2.36074925
128negative regulation of interleukin-12 production (GO:0032695)2.35913760
129wound healing, spreading of epidermal cells (GO:0035313)2.35708037
130copper ion homeostasis (GO:0055070)2.35254834
131telomere maintenance via semi-conservative replication (GO:0032201)2.34620537
132actin nucleation (GO:0045010)2.31541836
133DNA strand elongation (GO:0022616)2.31422735
134lytic vacuole organization (GO:0080171)2.31376731
135lysosome organization (GO:0007040)2.31376731
136regulation of heterotypic cell-cell adhesion (GO:0034114)2.30950093
137virion attachment to host cell (GO:0019062)2.30936344
138adhesion of symbiont to host cell (GO:0044650)2.30936344
139positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.30284305
140macrophage activation involved in immune response (GO:0002281)2.29473195
141NADPH regeneration (GO:0006740)2.28998061
142leukotriene metabolic process (GO:0006691)2.28503737
143positive regulation of SMAD protein import into nucleus (GO:0060391)2.28186461
144cyclooxygenase pathway (GO:0019371)2.27869802
145response to thyroid hormone (GO:0097066)2.26664519
146antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.26424183
147glucosamine-containing compound catabolic process (GO:1901072)2.26377655
148positive regulation of interferon-beta production (GO:0032728)2.26336029
149cellular response to thyroid hormone stimulus (GO:0097067)2.26160341
150proline biosynthetic process (GO:0006561)2.26140844
151regulation of SMAD protein import into nucleus (GO:0060390)2.26052517
152mitotic nuclear envelope disassembly (GO:0007077)2.25852891
153decidualization (GO:0046697)2.24945339
154vitamin D metabolic process (GO:0042359)2.24928546
155aminoglycoside antibiotic metabolic process (GO:0030647)2.24321380
156low-density lipoprotein particle remodeling (GO:0034374)2.23467206
157detection of molecule of bacterial origin (GO:0032490)2.22878381
158regulation of integrin activation (GO:0033623)2.22420650
159regulation of podosome assembly (GO:0071801)2.22087962
160regulation of fibrinolysis (GO:0051917)2.20865186
161heme metabolic process (GO:0042168)2.20147405
162high-density lipoprotein particle remodeling (GO:0034375)2.20060183
163endodermal cell differentiation (GO:0035987)2.19783452
164positive regulation of gamma-delta T cell activation (GO:0046645)2.19288216
165diol metabolic process (GO:0034311)2.19080512
166pentose metabolic process (GO:0019321)2.19054806
167valine metabolic process (GO:0006573)2.17324920
168peptidyl-proline hydroxylation (GO:0019511)2.17170120
169viral life cycle (GO:0019058)2.16029224
170positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.15829201
171L-alpha-amino acid transmembrane transport (GO:1902475)2.15382688
172positive regulation of lymphocyte apoptotic process (GO:0070230)2.15215628
173positive regulation of T cell apoptotic process (GO:0070234)2.14935434
174respiratory burst (GO:0045730)2.11858274
175response to interferon-alpha (GO:0035455)2.11846979
176retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.11812497
177ribosome biogenesis (GO:0042254)2.10849272
178ribosome assembly (GO:0042255)2.10821769
179telomere maintenance via recombination (GO:0000722)2.10355569
180regulation of antigen processing and presentation (GO:0002577)2.09646136
181regulation of B cell receptor signaling pathway (GO:0050855)2.09380656
182blood vessel maturation (GO:0001955)2.08373542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.64814507
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.04233663
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.72322284
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21222116
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.73332153
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.71280330
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.68550519
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.53660613
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.41339798
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.24489812
11ZNF263_19887448_ChIP-Seq_K562_Human2.22981274
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14509962
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10569019
14CLOCK_20551151_ChIP-Seq_293T_Human2.05928114
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03901382
16MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99817496
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.98899069
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97145443
19PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94526854
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93220870
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93079876
22MYC_22102868_ChIP-Seq_BL_Human1.91897627
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91689213
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.90238762
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.90130898
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88629609
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.87391869
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.86131828
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85659721
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84882990
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83987318
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.83292899
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82994489
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79974410
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79316023
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79307432
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77871307
38* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75004393
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74892767
40* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74080242
41SPI1_23547873_ChIP-Seq_NB4_Human1.73391777
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.73113593
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72324385
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67952962
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67536908
46VDR_21846776_ChIP-Seq_THP-1_Human1.67494652
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65674868
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65640019
49AR_21909140_ChIP-Seq_LNCAP_Human1.64582347
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63869308
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62043844
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61974562
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.61523484
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60606110
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59567734
56TFEB_21752829_ChIP-Seq_HELA_Human1.57138792
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56796555
58* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56183731
59SOX2_20726797_ChIP-Seq_SW620_Human1.55740477
60VDR_23849224_ChIP-Seq_CD4+_Human1.54375201
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.53450336
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.49349139
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48747913
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48579558
65* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47548195
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44245685
67GATA1_22025678_ChIP-Seq_K562_Human1.43587950
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42615833
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41569919
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41482591
71ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41371028
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40928565
73XRN2_22483619_ChIP-Seq_HELA_Human1.39787532
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37429737
75FOXM1_23109430_ChIP-Seq_U2OS_Human1.36641246
76DCP1A_22483619_ChIP-Seq_HELA_Human1.35878455
77GABP_19822575_ChIP-Seq_HepG2_Human1.35309580
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35112112
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31068015
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.29993370
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29767098
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29671949
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26484262
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26484262
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26234689
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.26126037
87MYB_26560356_Chip-Seq_TH2_Human1.25531673
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25321381
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25051047
90VDR_24763502_ChIP-Seq_THP-1_Human1.24262772
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24160666
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24061095
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.23346708
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21058039
95FOXP3_21729870_ChIP-Seq_TREG_Human1.20223372
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.19972904
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17117601
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16941739
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.16557699
100MAF_26560356_Chip-Seq_TH1_Human1.15382123
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15065863
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14459813
103GATA4_25053715_ChIP-Seq_YYC3_Human1.14223631
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14037095
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13229450
106GATA6_25053715_ChIP-Seq_YYC3_Human1.13183229
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12362660
108* EOMES_21245162_ChIP-Seq_HESCs_Human1.12340475
109RACK7_27058665_Chip-Seq_MCF-7_Human1.12317166
110CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12218608
111SCL_19346495_ChIP-Seq_HPC-7_Human1.12024741
112ELK1_19687146_ChIP-ChIP_HELA_Human1.11258112
113ATF3_27146783_Chip-Seq_COLON_Human1.11226874
114BP1_19119308_ChIP-ChIP_Hs578T_Human1.10312804
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10235987
116PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10231799
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09389480
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08958582
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08831724
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07801538
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07231977
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06822188
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06428159
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05755274
125MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05640856
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05494606
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04652109
128MYB_26560356_Chip-Seq_TH1_Human1.04611834
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03803031
130E2F1_21310950_ChIP-Seq_MCF-7_Human1.03146423
131TTF2_22483619_ChIP-Seq_HELA_Human1.02644085
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01835917
133PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01822600
134CIITA_25753668_ChIP-Seq_RAJI_Human1.01699142
135MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01228097
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00397631
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99292376
138* SPI1_23127762_ChIP-Seq_K562_Human0.99120430
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98833567
140HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98624507
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98495509
142E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98342913
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97665955
144TP63_17297297_ChIP-ChIP_HaCaT_Human0.97407517
145UTX_26944678_Chip-Seq_JUKART_Human0.95989800
146PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95632201
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95263955
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95027089
149* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94058712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.91120519
2MP0002139_abnormal_hepatobiliary_system3.26111274
3MP0008438_abnormal_cutaneous_collagen2.87062917
4MP0001835_abnormal_antigen_presentation2.46597839
5MP0003172_abnormal_lysosome_physiology2.27681728
6MP0010352_gastrointestinal_tract_polyps2.24956889
7MP0003693_abnormal_embryo_hatching2.21813385
8MP0002254_reproductive_system_inflammat2.20403535
9MP0009333_abnormal_splenocyte_physiolog2.15204695
10MP0002396_abnormal_hematopoietic_system2.11209921
11MP0003300_gastrointestinal_ulcer2.10526654
12MP0005257_abnormal_intraocular_pressure2.10100866
13MP0005365_abnormal_bile_salt2.08015325
14MP0000604_amyloidosis1.97187994
15MP0003436_decreased_susceptibility_to1.93038851
16MP0009840_abnormal_foam_cell1.91503061
17MP0005451_abnormal_body_composition1.81869627
18MP0010307_abnormal_tumor_latency1.77772534
19MP0010234_abnormal_vibrissa_follicle1.77558656
20MP0006054_spinal_hemorrhage1.75654073
21MP0003566_abnormal_cell_adhesion1.75320253
22MP0000490_abnormal_crypts_of1.73213525
23* MP0002419_abnormal_innate_immunity1.70214639
24MP0000685_abnormal_immune_system1.68642776
25MP0003705_abnormal_hypodermis_morpholog1.67303283
26MP0003724_increased_susceptibility_to1.65588807
27MP0003941_abnormal_skin_development1.63242652
28MP0003195_calcinosis1.58927146
29MP0005408_hypopigmentation1.58038417
30MP0001790_abnormal_immune_system1.56793957
31MP0005387_immune_system_phenotype1.56793957
32MP0005025_abnormal_response_to1.56719233
33* MP0002452_abnormal_antigen_presenting1.54360628
34MP0004957_abnormal_blastocyst_morpholog1.53913551
35MP0005000_abnormal_immune_tolerance1.53035987
36MP0005464_abnormal_platelet_physiology1.50425378
37MP0004808_abnormal_hematopoietic_stem1.50022089
38MP0006082_CNS_inflammation1.49669346
39MP0000858_altered_metastatic_potential1.49626445
40MP0008007_abnormal_cellular_replicative1.48994380
41MP0009278_abnormal_bone_marrow1.46126632
42MP0009643_abnormal_urine_homeostasis1.45918013
43MP0009785_altered_susceptibility_to1.45887249
44MP0001533_abnormal_skeleton_physiology1.44814136
45MP0005023_abnormal_wound_healing1.44724915
46MP0002166_altered_tumor_susceptibility1.43453454
47MP0001545_abnormal_hematopoietic_system1.42038279
48MP0005397_hematopoietic_system_phenotyp1.42038279
49MP0001756_abnormal_urination1.40141432
50MP0002148_abnormal_hypersensitivity_rea1.38637199
51* MP0001819_abnormal_immune_cell1.35486682
52MP0001845_abnormal_inflammatory_respons1.35413086
53* MP0002420_abnormal_adaptive_immunity1.35073565
54MP0001800_abnormal_humoral_immune1.34345305
55MP0003111_abnormal_nucleus_morphology1.34265234
56MP0000343_altered_response_to1.33896608
57MP0003448_altered_tumor_morphology1.33574575
58MP0003329_amyloid_beta_deposits1.33447873
59MP0005671_abnormal_response_to1.33366922
60MP0003186_abnormal_redox_activity1.31792218
61MP0008004_abnormal_stomach_pH1.31154622
62MP0002723_abnormal_immune_serum1.30380380
63MP0003075_altered_response_to1.29246987
64* MP0000689_abnormal_spleen_morphology1.28924299
65MP0003191_abnormal_cellular_cholesterol1.27545234
66MP0001958_emphysema1.26683652
67MP0010155_abnormal_intestine_physiology1.25644110
68MP0005165_increased_susceptibility_to1.24402799
69MP0005360_urolithiasis1.23877828
70MP0002405_respiratory_system_inflammati1.22982386
71MP0003806_abnormal_nucleotide_metabolis1.21609934
72MP0005085_abnormal_gallbladder_physiolo1.20683687
73MP0004264_abnormal_extraembryonic_tissu1.20494609
74MP0005076_abnormal_cell_differentiation1.20210135
75MP0001666_abnormal_nutrient_absorption1.18861501
76* MP0002398_abnormal_bone_marrow1.18804923
77MP0004272_abnormal_basement_membrane1.18690806
78* MP0002722_abnormal_immune_system1.18072593
79MP0000465_gastrointestinal_hemorrhage1.17080529
80MP0005310_abnormal_salivary_gland1.15895785
81MP0002136_abnormal_kidney_physiology1.15297074
82MP0002295_abnormal_pulmonary_circulatio1.14800083
83* MP0000716_abnormal_immune_system1.14393753
84MP0010386_abnormal_urinary_bladder1.14184895
85MP0003950_abnormal_plasma_membrane1.13634222
86* MP0002429_abnormal_blood_cell1.13157832
87MP0003077_abnormal_cell_cycle1.11277923
88MP0002877_abnormal_melanocyte_morpholog1.11255404
89MP0002060_abnormal_skin_morphology1.10971532
90MP0005503_abnormal_tendon_morphology1.10562810
91MP0001873_stomach_inflammation1.10459969
92MP0003303_peritoneal_inflammation1.08780719
93MP0005164_abnormal_response_to1.08453605
94MP0010329_abnormal_lipoprotein_level1.08427114
95MP0001243_abnormal_dermal_layer1.08391726
96MP0008469_abnormal_protein_level1.07611806
97MP0004947_skin_inflammation1.05037822
98MP0005275_abnormal_skin_tensile1.05035006
99MP0003453_abnormal_keratinocyte_physiol1.04776201
100MP0003183_abnormal_peptide_metabolism1.04479223
101MP0001849_ear_inflammation1.04162354
102MP0002090_abnormal_vision1.03753442
103MP0008875_abnormal_xenobiotic_pharmacok1.00074448
104MP0003279_aneurysm0.99401175
105MP0002006_tumorigenesis0.98708802
106MP0005174_abnormal_tail_pigmentation0.96189280
107MP0002019_abnormal_tumor_incidence0.95664232
108MP0002896_abnormal_bone_mineralization0.94801429
109MP0003795_abnormal_bone_structure0.94526689
110MP0010094_abnormal_chromosome_stability0.91920752
111MP0005390_skeleton_phenotype0.91535213
112MP0005319_abnormal_enzyme/_coenzyme0.91378126
113MP0003091_abnormal_cell_migration0.90904584
114MP0005220_abnormal_exocrine_pancreas0.90768549
115MP0003763_abnormal_thymus_physiology0.90347040
116MP0003866_abnormal_defecation0.90325844
117MP0001542_abnormal_bone_strength0.90118659
118MP0000609_abnormal_liver_physiology0.89272359
119MP0000358_abnormal_cell_content/0.88260303
120MP0004019_abnormal_vitamin_homeostasis0.87274075
121* MP0002135_abnormal_kidney_morphology0.86804699
122MP0003122_maternal_imprinting0.84961460
123MP0001853_heart_inflammation0.83655535
124MP0001915_intracranial_hemorrhage0.83421818
125MP0000371_diluted_coat_color0.82816788
126MP0002998_abnormal_bone_remodeling0.82300269
127MP0005332_abnormal_amino_acid0.82299655
128MP0003656_abnormal_erythrocyte_physiolo0.80765799
129MP0003567_abnormal_fetal_cardiomyocyte0.80764240
130MP0001216_abnormal_epidermal_layer0.80601023
131MP0001764_abnormal_homeostasis0.80510231
132* MP0000598_abnormal_liver_morphology0.79655056
133MP0009384_cardiac_valve_regurgitation0.78905438
134MP0010368_abnormal_lymphatic_system0.78481774
135MP0005367_renal/urinary_system_phenotyp0.78098758
136MP0000516_abnormal_urinary_system0.78098758
137MP0002933_joint_inflammation0.77247480
138MP0009764_decreased_sensitivity_to0.76108236
139MP0001661_extended_life_span0.75968921
140MP0002098_abnormal_vibrissa_morphology0.75867738
141MP0004147_increased_porphyrin_level0.74889050
142MP0001730_embryonic_growth_arrest0.73610974
143MP0008260_abnormal_autophagy0.73323609
144MP0000767_abnormal_smooth_muscle0.70863277
145MP0004883_abnormal_blood_vessel0.68907671
146MP0005584_abnormal_enzyme/coenzyme_acti0.68774931
147MP0005248_abnormal_Harderian_gland0.68337499
148MP0010678_abnormal_skin_adnexa0.68171981
149MP0002118_abnormal_lipid_homeostasis0.67735684
150MP0000537_abnormal_urethra_morphology0.63731771

Predicted human phenotypes

RankGene SetZ-score
1* Vacuolated lymphocytes (HP:0001922)4.95666542
2Dysostosis multiplex (HP:0000943)4.68967575
3Increased cerebral lipofuscin (HP:0011813)3.91771515
4* Urinary glycosaminoglycan excretion (HP:0003541)3.68873719
5* Mucopolysacchariduria (HP:0008155)3.68873719
6Systemic lupus erythematosus (HP:0002725)3.66428383
7Petechiae (HP:0000967)3.48526858
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.47938234
9Recurrent abscess formation (HP:0002722)3.41952865
10Thrombocytosis (HP:0001894)3.40534427
11Eczematoid dermatitis (HP:0000976)3.40080569
12* Abnormality of polysaccharide metabolism (HP:0011012)3.30674136
13* Abnormality of glycosaminoglycan metabolism (HP:0004371)3.30674136
14* Abnormality of mucopolysaccharide metabolism (HP:0011020)3.30674136
15* Cervical subluxation (HP:0003308)3.16904855
16Abnormality of liposaccharide metabolism (HP:0010968)3.00767010
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.00767010
18Abnormality of glycolipid metabolism (HP:0010969)3.00767010
19Abnormal gallbladder physiology (HP:0012438)2.97247017
20Cholecystitis (HP:0001082)2.97247017
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.93976687
22Nuclear cataract (HP:0100018)2.93180726
23IgM deficiency (HP:0002850)2.80991430
24Myocardial infarction (HP:0001658)2.78951178
25Prolonged neonatal jaundice (HP:0006579)2.75107441
26Deep venous thrombosis (HP:0002625)2.74320364
27Recurrent bacterial skin infections (HP:0005406)2.73889296
28Pustule (HP:0200039)2.73321529
29* Abnormality of macrophages (HP:0004311)2.68219485
30Reticulocytopenia (HP:0001896)2.67564510
31* Progressive neurologic deterioration (HP:0002344)2.65907777
32Vascular calcification (HP:0004934)2.64754451
33Mitral stenosis (HP:0001718)2.62572257
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61964150
35Cardiovascular calcification (HP:0011915)2.59568994
36Elevated erythrocyte sedimentation rate (HP:0003565)2.54107796
37Aplastic anemia (HP:0001915)2.46878150
38Amyloidosis (HP:0011034)2.46859837
39Myositis (HP:0100614)2.46395771
40Xanthomatosis (HP:0000991)2.45292580
41Abnormality of the common coagulation pathway (HP:0010990)2.43746560
42Hand muscle atrophy (HP:0009130)2.42143552
43Poor head control (HP:0002421)2.40381183
44Loss of speech (HP:0002371)2.38235793
45Agnosia (HP:0010524)2.37595910
46Ankle contracture (HP:0006466)2.36424877
47Protrusio acetabuli (HP:0003179)2.35948812
48Spondylolisthesis (HP:0003302)2.35811422
49Hepatosplenomegaly (HP:0001433)2.32459457
50Complement deficiency (HP:0004431)2.30866554
51Vertebral compression fractures (HP:0002953)2.28392316
52Intrahepatic cholestasis (HP:0001406)2.26523682
53Osteolytic defects of the hand bones (HP:0009699)2.25978486
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.25978486
55Cerebral aneurysm (HP:0004944)2.25006724
56* Ovoid vertebral bodies (HP:0003300)2.24117281
57Interstitial pulmonary disease (HP:0006530)2.23022316
58* Joint stiffness (HP:0001387)2.22482233
59Gingival bleeding (HP:0000225)2.20961505
60Hypokinesia (HP:0002375)2.19518603
61Autoimmune thrombocytopenia (HP:0001973)2.16464297
62Metaphyseal irregularity (HP:0003025)2.14837205
63Abnormality of the anterior horn cell (HP:0006802)2.13661070
64Degeneration of anterior horn cells (HP:0002398)2.13661070
65Multiple enchondromatosis (HP:0005701)2.12843422
66Rough bone trabeculation (HP:0100670)2.11029463
67Abnormality of complement system (HP:0005339)2.10026533
68Bone pain (HP:0002653)2.09807571
69Persistence of primary teeth (HP:0006335)2.04657411
70Neurofibrillary tangles (HP:0002185)2.04386336
71Chronic otitis media (HP:0000389)2.03850163
72Abnormal delivery (HP:0001787)2.02789588
73Tetraparesis (HP:0002273)2.01796580
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00039822
75Asymmetric septal hypertrophy (HP:0001670)1.99798574
76Esophageal neoplasm (HP:0100751)1.99770463
77Neoplasm of head and neck (HP:0012288)1.99770463
78Upper motor neuron abnormality (HP:0002127)1.99189469
79Premature rupture of membranes (HP:0001788)1.98765553
80J-shaped sella turcica (HP:0002680)1.98095441
81Generalized aminoaciduria (HP:0002909)1.97607077
82Nausea (HP:0002018)1.96457850
83Abnormal platelet function (HP:0011869)1.94708256
84Impaired platelet aggregation (HP:0003540)1.94708256
85Arterial thrombosis (HP:0004420)1.94669208
86Glomerulonephritis (HP:0000099)1.93894103
87Hypoalphalipoproteinemia (HP:0003233)1.91153612
88Gout (HP:0001997)1.88647419
89Diminished motivation (HP:0000745)1.87635972
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87352291
91Apathy (HP:0000741)1.87275533
92Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85972818
93Thin bony cortex (HP:0002753)1.85906483
94Protuberant abdomen (HP:0001538)1.85855261
95Thoracic kyphosis (HP:0002942)1.84695743
96Polyuria (HP:0000103)1.84226933
97Pathologic fracture (HP:0002756)1.84223234
98Spinal muscular atrophy (HP:0007269)1.82549204
99Type I transferrin isoform profile (HP:0003642)1.82193891
100Increased serum ferritin (HP:0003281)1.82184719
101Skin nodule (HP:0200036)1.81112604
102Vascular tortuosity (HP:0004948)1.80753792
103Atrophic scars (HP:0001075)1.80703710
104Recurrent viral infections (HP:0004429)1.80661653
105Abnormality of the distal phalanges of the toes (HP:0010182)1.80617518
106Disinhibition (HP:0000734)1.80277667
107Abnormal trabecular bone morphology (HP:0100671)1.79013815
108Axonal loss (HP:0003447)1.78969713
109Increased CSF protein (HP:0002922)1.78507476
110Hyperammonemia (HP:0001987)1.77928409
111* Beaking of vertebral bodies (HP:0004568)1.77896503
112Recurrent fungal infections (HP:0002841)1.77848086
113Hypolipoproteinemia (HP:0010981)1.77629668
114Gingivitis (HP:0000230)1.76907818
115Short nail (HP:0001799)1.75961771
116Orchitis (HP:0100796)1.75657412
117Cutaneous melanoma (HP:0012056)1.75410420
118Proximal tubulopathy (HP:0000114)1.75355674
119Aortic dissection (HP:0002647)1.74245882
120Abnormality of carpal bone ossification (HP:0006257)1.73998864
121Joint hemorrhage (HP:0005261)1.73934562
122Enlarged penis (HP:0000040)1.73658476
123Arterial tortuosity (HP:0005116)1.73012875
124Abnormality of the Achilles tendon (HP:0005109)1.72495453
125Steatorrhea (HP:0002570)1.72495395
126Abnormality of cells of the erythroid lineage (HP:0012130)1.71214974
127Cardiomegaly (HP:0001640)1.71175173
128Abnormality of the lumbar spine (HP:0100712)1.69509677
129Recurrent gram-negative bacterial infections (HP:0005420)1.68729832
130Abnormal urine output (HP:0012590)1.68660514
131Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68420006
132Blue sclerae (HP:0000592)1.68229816
133* Abnormality of the acetabulum (HP:0003170)1.67920768
134Abnormality of pyrimidine metabolism (HP:0004353)1.67890487
135Wrist flexion contracture (HP:0001239)1.67830288
136Fatigue (HP:0012378)1.67329838
137Hypophosphatemic rickets (HP:0004912)1.66834342
138Microretrognathia (HP:0000308)1.66798119
139Fat malabsorption (HP:0002630)1.65820485
140Purpura (HP:0000979)1.65538420
141Prolonged partial thromboplastin time (HP:0003645)1.65262747
142Right ventricular cardiomyopathy (HP:0011663)1.63627787
143Retinal atrophy (HP:0001105)1.63135513
144Abnormality of fatty-acid metabolism (HP:0004359)1.61916547
14511 pairs of ribs (HP:0000878)1.61471048
146Abnormal number of erythroid precursors (HP:0012131)1.61254408
147Upper limb amyotrophy (HP:0009129)1.60674060
148Distal upper limb amyotrophy (HP:0007149)1.60674060
149Cellulitis (HP:0100658)1.60243409
150Microglossia (HP:0000171)1.59412396
151Hematochezia (HP:0002573)1.59375047
152Emphysema (HP:0002097)1.59204775
153Reduced antithrombin III activity (HP:0001976)1.59013397
154Carpal bone hypoplasia (HP:0001498)1.58643962
155Prolonged bleeding time (HP:0003010)1.57254849
156Abnormal protein glycosylation (HP:0012346)1.56518439
157Abnormal glycosylation (HP:0012345)1.56518439
158Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.56518439
159Abnormal protein N-linked glycosylation (HP:0012347)1.56518439
160Abnormality of T cell physiology (HP:0011840)1.55952596
161Hyperglycinuria (HP:0003108)1.55754147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK23.10412280
2NME22.99964682
3MAP3K122.95279987
4EEF2K2.58034542
5ERN12.56314257
6SCYL22.55612430
7CCNB12.53041363
8TRIB32.32167992
9KIT2.31802288
10MAP4K12.31312121
11WEE12.14926453
12PIM22.09055128
13PBK1.94533698
14PKN21.94248437
15FLT31.93787601
16MYLK1.85138326
17TGFBR21.84758063
18BLK1.82161680
19TYK21.81267634
20ZAP701.77474211
21PAK41.70093619
22EPHB21.68526267
23LRRK21.66363130
24LIMK11.63137798
25FER1.62125015
26BUB11.61404000
27TSSK61.61260936
28EIF2AK11.55496201
29EIF2AK31.53236937
30RPS6KA41.52461206
31DDR21.50191486
32JAK31.49852506
33EPHA21.49770945
34BCKDK1.48542053
35EPHB11.48440870
36RIPK11.45872104
37MAPKAPK31.41732623
38EPHA31.41304026
39STK161.40708498
40ABL21.40001522
41NEK91.38747258
42TAOK31.37359375
43MAP3K31.37041874
44PTK21.36827929
45TBK11.35442365
46CSF1R1.31279330
47BTK1.30817840
48BRSK21.28952315
49IRAK31.28278612
50NEK21.28159269
51TAOK21.27264984
52STK101.25531157
53MST1R1.23945581
54TESK21.20786187
55GRK71.19790563
56TGFBR11.19514060
57FGFR41.19330869
58MAP2K31.19093618
59MATK1.17011762
60TRPM71.15965222
61LMTK21.13851151
62TEC1.13417703
63RPS6KB21.13048170
64TESK11.12218454
65PDGFRA1.09979181
66NEK11.09321069
67FGR1.04844690
68ADRBK21.04253002
69PASK1.00501559
70IRAK40.96779719
71CLK10.95620284
72CDC42BPA0.94470146
73PIK3CA0.94386194
74PIM10.91098507
75MST40.90277777
76WNK30.90201703
77SIK30.89025251
78MOS0.87405959
79KDR0.85372454
80PTK60.83946752
81IKBKB0.83743933
82CSNK1G30.83354919
83DYRK30.82893543
84MAP2K20.82590402
85MAP3K80.81204012
86MAP3K110.77039218
87SYK0.76161297
88MAP3K20.75234425
89PRKG20.73398639
90CAMKK20.72263770
91NTRK10.69823365
92CSNK1G10.69393386
93ACVR1B0.67173337
94NLK0.66754014
95JAK10.65881594
96CSNK1A1L0.65375368
97GRK60.64758595
98INSRR0.64361865
99LYN0.63550393
100CDK40.63526898
101MET0.63080204
102ZAK0.61419952
103ARAF0.59947198
104CDK70.59876645
105ATR0.59024114
106YES10.58874185
107MAP3K140.58761127
108TXK0.58735513
109MAP3K10.58042674
110LCK0.57713715
111TRIM280.55258853
112BMX0.55058635
113AURKB0.54127278
114DAPK30.53864225
115DAPK10.53703833
116CDC70.53182121
117IRAK10.53066987
118ERBB40.50351182
119MAP3K100.49623729
120RPS6KA20.49612353
121PAK10.49133542
122LATS20.49019477
123ILK0.48867127
124ROCK20.46898818
125RPS6KA60.45808174
126PAK20.45787398
127VRK10.45597806
128JAK20.45595794
129SIK10.45151762
130RPS6KC10.44589693
131RPS6KL10.44589693
132PLK10.44555964
133GSK3A0.43883723
134ITK0.43596550
135MAPKAPK20.43406182
136CSK0.43191407
137HCK0.43128267
138CDK60.42085554
139FGFR30.40524964
140FRK0.39818381
141ERBB30.39173837
142PDPK10.37283342
143ABL10.35516123
144MAP2K60.35072977
145CSNK1G20.32748110
146STK380.32405958
147LATS10.32209328
148CDK80.31257504

Predicted pathways (KEGG)

RankGene SetZ-score
1* Other glycan degradation_Homo sapiens_hsa005113.59775854
2* Glycosaminoglycan degradation_Homo sapiens_hsa005312.98922971
3* Lysosome_Homo sapiens_hsa041422.92264186
4DNA replication_Homo sapiens_hsa030302.70139074
5Complement and coagulation cascades_Homo sapiens_hsa046102.49060916
6Fatty acid elongation_Homo sapiens_hsa000622.48784844
7Proteasome_Homo sapiens_hsa030502.24095573
8Ribosome_Homo sapiens_hsa030102.14946128
9Antigen processing and presentation_Homo sapiens_hsa046122.07211597
10Steroid biosynthesis_Homo sapiens_hsa001002.06619001
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.03709355
12Sulfur metabolism_Homo sapiens_hsa009202.03645936
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.00495087
14Mismatch repair_Homo sapiens_hsa034301.89543714
15Legionellosis_Homo sapiens_hsa051341.88403119
16Protein export_Homo sapiens_hsa030601.83087227
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77166248
18Base excision repair_Homo sapiens_hsa034101.65268889
19Leishmaniasis_Homo sapiens_hsa051401.63728323
20Renin-angiotensin system_Homo sapiens_hsa046141.57411077
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53367349
22Pentose phosphate pathway_Homo sapiens_hsa000301.50002531
23Staphylococcus aureus infection_Homo sapiens_hsa051501.47127727
24Folate biosynthesis_Homo sapiens_hsa007901.46921231
25N-Glycan biosynthesis_Homo sapiens_hsa005101.45841939
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43267187
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42004469
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40621360
29Pyrimidine metabolism_Homo sapiens_hsa002401.36178697
30RNA polymerase_Homo sapiens_hsa030201.32567358
31Pertussis_Homo sapiens_hsa051331.32225463
32RNA transport_Homo sapiens_hsa030131.30994752
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27632459
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26186540
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23858994
36* Sphingolipid metabolism_Homo sapiens_hsa006001.23290812
37One carbon pool by folate_Homo sapiens_hsa006701.23289869
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21136040
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20337134
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19740324
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18474022
42Nucleotide excision repair_Homo sapiens_hsa034201.15178867
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11640119
44Peroxisome_Homo sapiens_hsa041461.11296245
45Apoptosis_Homo sapiens_hsa042101.09552269
46Shigellosis_Homo sapiens_hsa051311.07718417
47Fructose and mannose metabolism_Homo sapiens_hsa000511.06961379
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.04897378
49p53 signaling pathway_Homo sapiens_hsa041151.04808929
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.04071853
51Tuberculosis_Homo sapiens_hsa051521.03521882
52Measles_Homo sapiens_hsa051621.03317890
53Fatty acid metabolism_Homo sapiens_hsa012121.00767015
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00724553
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99635152
56Phagosome_Homo sapiens_hsa041450.98747212
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.98555032
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97666904
59Cell cycle_Homo sapiens_hsa041100.97540251
60Toxoplasmosis_Homo sapiens_hsa051450.95713061
61Osteoclast differentiation_Homo sapiens_hsa043800.94728350
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.92499689
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92102066
64Herpes simplex infection_Homo sapiens_hsa051680.91441067
65Glutathione metabolism_Homo sapiens_hsa004800.90703473
66Spliceosome_Homo sapiens_hsa030400.90554919
67* Galactose metabolism_Homo sapiens_hsa000520.90096323
68Rheumatoid arthritis_Homo sapiens_hsa053230.87946126
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87084946
70Influenza A_Homo sapiens_hsa051640.85978240
71Malaria_Homo sapiens_hsa051440.85794178
72Hematopoietic cell lineage_Homo sapiens_hsa046400.85586978
73Starch and sucrose metabolism_Homo sapiens_hsa005000.83070942
74PPAR signaling pathway_Homo sapiens_hsa033200.81286960
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80078568
76Fatty acid degradation_Homo sapiens_hsa000710.79009941
77Biosynthesis of amino acids_Homo sapiens_hsa012300.78839695
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78281069
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77346638
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76630103
81Epstein-Barr virus infection_Homo sapiens_hsa051690.76007963
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75605136
83Arachidonic acid metabolism_Homo sapiens_hsa005900.74730800
84Tryptophan metabolism_Homo sapiens_hsa003800.73712892
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.73480899
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73075661
87Tyrosine metabolism_Homo sapiens_hsa003500.72034252
88Small cell lung cancer_Homo sapiens_hsa052220.71720779
89Primary immunodeficiency_Homo sapiens_hsa053400.71714933
90Regulation of autophagy_Homo sapiens_hsa041400.71660897
91Hepatitis B_Homo sapiens_hsa051610.71399305
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.71157311
93Phenylalanine metabolism_Homo sapiens_hsa003600.71069941
94Vitamin digestion and absorption_Homo sapiens_hsa049770.69789811
95Carbon metabolism_Homo sapiens_hsa012000.69729568
96Acute myeloid leukemia_Homo sapiens_hsa052210.69598444
97Homologous recombination_Homo sapiens_hsa034400.68676118
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67946517
99Chemical carcinogenesis_Homo sapiens_hsa052040.66103535
100Thyroid cancer_Homo sapiens_hsa052160.66081830
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65851013
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65639993
103Viral carcinogenesis_Homo sapiens_hsa052030.64943278
104Vibrio cholerae infection_Homo sapiens_hsa051100.64310227
105Selenocompound metabolism_Homo sapiens_hsa004500.63932061
106Arginine biosynthesis_Homo sapiens_hsa002200.62746708
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62631261
108Asthma_Homo sapiens_hsa053100.59940503
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59819230
110Prion diseases_Homo sapiens_hsa050200.59780752
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59642297
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.58920365
113Chronic myeloid leukemia_Homo sapiens_hsa052200.58568568
114Protein digestion and absorption_Homo sapiens_hsa049740.58286843
115Vitamin B6 metabolism_Homo sapiens_hsa007500.58223897
116Pyruvate metabolism_Homo sapiens_hsa006200.57876859
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55507169
118Amoebiasis_Homo sapiens_hsa051460.54214464
119Mineral absorption_Homo sapiens_hsa049780.54009622
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53996471
121B cell receptor signaling pathway_Homo sapiens_hsa046620.52569071
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52429259
123* Metabolic pathways_Homo sapiens_hsa011000.51194515
124Sulfur relay system_Homo sapiens_hsa041220.51072908
125HIF-1 signaling pathway_Homo sapiens_hsa040660.50529156
126Viral myocarditis_Homo sapiens_hsa054160.47549261
127Bladder cancer_Homo sapiens_hsa052190.46673324
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.46539213
129Salmonella infection_Homo sapiens_hsa051320.45600023
130HTLV-I infection_Homo sapiens_hsa051660.45565982
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44839640
132TNF signaling pathway_Homo sapiens_hsa046680.44717771
133Purine metabolism_Homo sapiens_hsa002300.43388218
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42918055
135Caffeine metabolism_Homo sapiens_hsa002320.42881075
136Pancreatic cancer_Homo sapiens_hsa052120.42874034
137Hepatitis C_Homo sapiens_hsa051600.42828913
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42522523
139Proteoglycans in cancer_Homo sapiens_hsa052050.42129179
140Collecting duct acid secretion_Homo sapiens_hsa049660.39221626
141ECM-receptor interaction_Homo sapiens_hsa045120.38510684
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38502230
143Propanoate metabolism_Homo sapiens_hsa006400.37811350
144Fat digestion and absorption_Homo sapiens_hsa049750.37060470
145* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37057324
146Retinol metabolism_Homo sapiens_hsa008300.32603602
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.32478097
148Adherens junction_Homo sapiens_hsa045200.31256215
149Arginine and proline metabolism_Homo sapiens_hsa003300.30706578
150Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30420740

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