GLB1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.48585411
2cilium or flagellum-dependent cell motility (GO:0001539)7.58617378
3motile cilium assembly (GO:0044458)6.99418288
4cilium movement (GO:0003341)6.80110150
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.72912195
6epithelial cilium movement (GO:0003351)6.02521941
7low-density lipoprotein particle clearance (GO:0034383)5.98773785
8valine metabolic process (GO:0006573)5.93605682
9Golgi transport vesicle coating (GO:0048200)5.10274502
10COPI coating of Golgi vesicle (GO:0048205)5.10274502
11triglyceride catabolic process (GO:0019433)4.89444389
12white fat cell differentiation (GO:0050872)4.88487724
13biotin metabolic process (GO:0006768)4.88003599
14brown fat cell differentiation (GO:0050873)4.65602979
15vitamin transmembrane transport (GO:0035461)4.58655625
16neutral lipid catabolic process (GO:0046461)4.44184378
17acylglycerol catabolic process (GO:0046464)4.44184378
18axoneme assembly (GO:0035082)4.44177305
19negative regulation of T cell differentiation in thymus (GO:0033085)4.39998301
20tricarboxylic acid metabolic process (GO:0072350)4.39599021
21regulation of sequestering of triglyceride (GO:0010889)4.34177987
22branched-chain amino acid metabolic process (GO:0009081)4.30788049
23regulation of cilium movement (GO:0003352)4.27844545
24left/right pattern formation (GO:0060972)4.25213567
25fatty acid beta-oxidation (GO:0006635)4.21608409
26response to dietary excess (GO:0002021)4.11322215
27triglyceride biosynthetic process (GO:0019432)4.08755429
28diterpenoid biosynthetic process (GO:0016102)4.06376853
29acylglycerol biosynthetic process (GO:0046463)3.89645384
30neutral lipid biosynthetic process (GO:0046460)3.89645384
31fatty acid oxidation (GO:0019395)3.85753865
32establishment of monopolar cell polarity (GO:0061162)3.78517017
33establishment or maintenance of monopolar cell polarity (GO:0061339)3.78517017
34lipid oxidation (GO:0034440)3.77852143
35negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.77480311
36lung epithelium development (GO:0060428)3.76913506
37sensory perception of smell (GO:0007608)3.76734911
38establishment of apical/basal cell polarity (GO:0035089)3.75692283
39branched-chain amino acid catabolic process (GO:0009083)3.73732381
40drug transmembrane transport (GO:0006855)3.60909702
41adaptation of signaling pathway (GO:0023058)3.56943992
42intraciliary transport (GO:0042073)3.56381292
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.54592017
44fatty acid catabolic process (GO:0009062)3.51174203
45regulation of rhodopsin mediated signaling pathway (GO:0022400)3.50974095
46primary alcohol catabolic process (GO:0034310)3.49661167
47lipid particle organization (GO:0034389)3.46105129
48positive regulation of fatty acid beta-oxidation (GO:0032000)3.45510741
49terpenoid biosynthetic process (GO:0016114)3.45170431
502-oxoglutarate metabolic process (GO:0006103)3.43390658
51microtubule bundle formation (GO:0001578)3.41255334
52oxaloacetate metabolic process (GO:0006107)3.39619873
53positive regulation of fatty acid oxidation (GO:0046321)3.38196168
54rhodopsin mediated signaling pathway (GO:0016056)3.36093857
55glycerolipid catabolic process (GO:0046503)3.33332681
56positive regulation of cellular response to insulin stimulus (GO:1900078)3.30376405
57photoreceptor cell maintenance (GO:0045494)3.30017644
58positive regulation of action potential (GO:0045760)3.26414805
59microtubule depolymerization (GO:0007019)3.24201146
60quaternary ammonium group transport (GO:0015697)3.23282819
61fatty acid transmembrane transport (GO:1902001)3.22197703
62fatty acid homeostasis (GO:0055089)3.21558993
63carnitine transport (GO:0015879)3.18966856
64amino-acid betaine transport (GO:0015838)3.18966856
65left/right axis specification (GO:0070986)3.17615049
66cilium organization (GO:0044782)3.17039287
67glycerol metabolic process (GO:0006071)3.16703202
68growth hormone receptor signaling pathway (GO:0060396)3.16080411
69CDP-diacylglycerol biosynthetic process (GO:0016024)3.15553140
70long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.14608989
71fatty-acyl-CoA biosynthetic process (GO:0046949)3.14494206
72cellular response to leptin stimulus (GO:0044320)3.13252059
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12896853
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.12896853
75regulation of cholesterol storage (GO:0010885)3.12537563
76cellular response to vitamin (GO:0071295)3.11885402
77cilium assembly (GO:0042384)3.11849581
78maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08817156
79acyl-CoA biosynthetic process (GO:0071616)3.06859573
80thioester biosynthetic process (GO:0035384)3.06859573
81regulation of translational fidelity (GO:0006450)3.05479854
82macroautophagy (GO:0016236)3.03789762
83triglyceride metabolic process (GO:0006641)3.02644092
84sulfur amino acid catabolic process (GO:0000098)3.00975464
85regulation of microtubule-based movement (GO:0060632)3.00876433
86positive regulation of insulin receptor signaling pathway (GO:0046628)3.00680276
87negative regulation of protein autophosphorylation (GO:0031953)2.98970980
88ventricular system development (GO:0021591)2.97571250
89positive regulation of glycolytic process (GO:0045821)2.97311523
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.96565037
91centriole assembly (GO:0098534)2.95954087
92transcytosis (GO:0045056)2.95637629
93COPII vesicle coating (GO:0048208)2.95521466
94response to leptin (GO:0044321)2.90817784
95long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.89164997
96lipid storage (GO:0019915)2.87765708
97CDP-diacylglycerol metabolic process (GO:0046341)2.87692553
98ethanol metabolic process (GO:0006067)2.86697356
99regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.86313736
100carnitine shuttle (GO:0006853)2.86304690
101lysine catabolic process (GO:0006554)2.85123705
102lysine metabolic process (GO:0006553)2.85123705
103membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.85092307
104positive regulation of glomerulus development (GO:0090193)2.84369557
105acylglycerol metabolic process (GO:0006639)2.84285416
106fatty-acyl-CoA metabolic process (GO:0035337)2.83348999
107negative regulation of metanephros development (GO:0072217)2.83035274
108short-chain fatty acid metabolic process (GO:0046459)2.82826119
109organic cation transport (GO:0015695)2.82136856
110NADH metabolic process (GO:0006734)2.82087254
111neutral lipid metabolic process (GO:0006638)2.80393192
112positive regulation of fatty acid metabolic process (GO:0045923)2.80255322
113adipose tissue development (GO:0060612)2.79782326
114carnitine transmembrane transport (GO:1902603)2.77174956
115regulation of glycogen (starch) synthase activity (GO:2000465)2.75674266
116alditol metabolic process (GO:0019400)2.74932144
117monocarboxylic acid catabolic process (GO:0072329)2.74844317
118cellular response to growth hormone stimulus (GO:0071378)2.74430417
119urate metabolic process (GO:0046415)2.74352250
120regulation of fatty acid beta-oxidation (GO:0031998)2.73330391
121protein retention in ER lumen (GO:0006621)2.71541827
122pyrimidine-containing compound transmembrane transport (GO:0072531)2.70372334
123regulation of cAMP-dependent protein kinase activity (GO:2000479)2.69160379
124drug transport (GO:0015893)2.68070867
125alpha-linolenic acid metabolic process (GO:0036109)2.64721253
126regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.64527934
127retina vasculature morphogenesis in camera-type eye (GO:0061299)2.64488964
128acetyl-CoA metabolic process (GO:0006084)2.62817511
129proline biosynthetic process (GO:0006561)2.61891562
130ER overload response (GO:0006983)2.61165452
131activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60141472
132endocrine pancreas development (GO:0031018)2.59493418
133sensory perception of chemical stimulus (GO:0007606)2.57658258
134DNA unwinding involved in DNA replication (GO:0006268)2.56448509
135lung secretory cell differentiation (GO:0061140)2.52336315
136dorsal/ventral neural tube patterning (GO:0021904)2.49833303
137GDP-mannose metabolic process (GO:0019673)2.47429249
138microtubule-based movement (GO:0007018)2.46034499
139membrane repolarization during action potential (GO:0086011)2.45956774
140UTP biosynthetic process (GO:0006228)2.44689716
141calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.42293265
142phenol-containing compound catabolic process (GO:0019336)2.42259940
143establishment of tissue polarity (GO:0007164)2.41862416
144establishment of planar polarity (GO:0001736)2.41862416
145positive regulation of protein targeting to membrane (GO:0090314)2.41477406
146DNA replication initiation (GO:0006270)2.39101842
147establishment or maintenance of apical/basal cell polarity (GO:0035088)2.38854023
148establishment or maintenance of bipolar cell polarity (GO:0061245)2.38854023
149microtubule polymerization or depolymerization (GO:0031109)2.36557046
150vitamin A metabolic process (GO:0006776)2.34733889
151behavioral response to nicotine (GO:0035095)2.33829581
152sperm capacitation (GO:0048240)2.33774276
153desmosome organization (GO:0002934)2.32903766
154multicellular organismal water homeostasis (GO:0050891)2.32645476
155nonmotile primary cilium assembly (GO:0035058)2.32150962
156cilium morphogenesis (GO:0060271)2.31957398
157positive regulation of smoothened signaling pathway (GO:0045880)2.31673716
158nucleoside diphosphate phosphorylation (GO:0006165)2.29903172
159one-carbon compound transport (GO:0019755)2.29662441
160UTP metabolic process (GO:0046051)2.27081542
161aldehyde catabolic process (GO:0046185)2.26880480
162retinoic acid metabolic process (GO:0042573)2.25652352
163negative regulation of epidermis development (GO:0045683)2.24189710
164GTP biosynthetic process (GO:0006183)2.22938035
165regulation of guanylate cyclase activity (GO:0031282)2.22805702
166cellular component assembly involved in morphogenesis (GO:0010927)2.21947786
167positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.15941779
168negative regulation of epidermal cell differentiation (GO:0045605)2.15491669
169cell projection assembly (GO:0030031)2.13204648
170DNA strand elongation involved in DNA replication (GO:0006271)2.12640926
171DNA replication checkpoint (GO:0000076)2.10742295
172glutathione biosynthetic process (GO:0006750)2.10423110
173pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.10193705
174protein localization to cilium (GO:0061512)2.09247918
175embryonic camera-type eye development (GO:0031076)2.08700645
176phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.07549157
177O-glycan processing (GO:0016266)2.07291536
178auditory receptor cell differentiation (GO:0042491)2.07186391
179pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.07084156
180behavioral response to ethanol (GO:0048149)2.05772005
181apical protein localization (GO:0045176)2.05484771
182regulation of action potential (GO:0098900)2.03563990
183epithelial cell maturation (GO:0002070)2.02163249
184renal system development (GO:0072001)2.01722172
185telomere maintenance via semi-conservative replication (GO:0032201)2.01520547
186vitamin transport (GO:0051180)2.00593803
187water homeostasis (GO:0030104)1.99056525
188microtubule severing (GO:0051013)1.99029028
189DNA strand elongation (GO:0022616)1.97932690
190establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)1.97625494
191ethanol oxidation (GO:0006069)1.97165477
192quinone biosynthetic process (GO:1901663)1.97107879
193positive regulation of digestive system process (GO:0060456)1.96165906
194pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)1.96088952
195sulfur compound transport (GO:0072348)1.95979413
196histone H2A acetylation (GO:0043968)1.94929227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.76715501
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.49028779
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.17539231
4GATA1_22025678_ChIP-Seq_K562_Human3.84991795
5E2F7_22180533_ChIP-Seq_HELA_Human3.74532835
6CLOCK_20551151_ChIP-Seq_293T_Human3.61458367
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.57345051
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.43942850
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.43397734
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.22387425
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08265519
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99878597
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94723436
14PPARA_22158963_ChIP-Seq_LIVER_Mouse1.81654282
15CTCF_27219007_Chip-Seq_Bcells_Human1.80064452
16P68_20966046_ChIP-Seq_HELA_Human1.79701652
17RACK7_27058665_Chip-Seq_MCF-7_Human1.77734407
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.77524807
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.74863803
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74774114
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.73467586
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71745032
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.71705923
24PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.71082093
25XRN2_22483619_ChIP-Seq_HELA_Human1.69666179
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.69607321
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67529712
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67071655
29ZNF263_19887448_ChIP-Seq_K562_Human1.66055235
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.61794659
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.60570970
32KDM5A_27292631_Chip-Seq_BREAST_Human1.60220291
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.60214581
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58543402
35SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.58152552
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57786991
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56795876
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53945742
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53190543
40AR_21909140_ChIP-Seq_LNCAP_Human1.53161967
41* ESR1_21235772_ChIP-Seq_MCF-7_Human1.52130580
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.52089857
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47485201
44SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.46887218
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44435577
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42246058
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42104199
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.40028803
49EZH2_22144423_ChIP-Seq_EOC_Human1.39968641
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38664789
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38002827
52PHF8_20622854_ChIP-Seq_HELA_Human1.37401438
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36975280
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36901112
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33656757
56AHR_22903824_ChIP-Seq_MCF-7_Human1.32798500
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.29466593
58TBX20_22080862_ChIP-Seq_HEART_Mouse1.29466593
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.29124559
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.28913879
61CTCF_20526341_ChIP-Seq_ESCs_Human1.27905143
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.26783253
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26345456
64E2F1_20622854_ChIP-Seq_HELA_Human1.24975746
65* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23879366
66FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.23249593
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.22504926
68GABP_19822575_ChIP-Seq_HepG2_Human1.22150566
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22101520
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.21962243
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21100141
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19491417
73GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.19351694
74SA1_27219007_Chip-Seq_Bcells_Human1.18073193
75FOXP1_21924763_ChIP-Seq_HESCs_Human1.17817484
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.16541142
77PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.15822026
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14774376
79CHD1_26751641_Chip-Seq_LNCaP_Human1.14212808
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13142788
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.12316919
82MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12314514
83KLF5_25053715_ChIP-Seq_YYC3_Human1.12257588
84GATA3_24758297_ChIP-Seq_MCF-7_Human1.11512050
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.10793399
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.10680009
87TTF2_22483619_ChIP-Seq_HELA_Human1.10545325
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.10004725
89SOX2_20726797_ChIP-Seq_SW620_Human1.09943565
90DROSHA_22980978_ChIP-Seq_HELA_Human1.09928806
91BCOR_27268052_Chip-Seq_Bcells_Human1.08835734
92RARA_24833708_ChIP-Seq_LIVER_Mouse1.08719141
93RARB_24833708_ChIP-Seq_LIVER_Mouse1.08328676
94ERA_21632823_ChIP-Seq_H3396_Human1.07989925
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07307822
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05748371
97E2F1_17053090_ChIP-ChIP_MCF-7_Human1.05461405
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.05314626
99GATA6_25053715_ChIP-Seq_YYC3_Human1.05257051
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05004697
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04633378
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03330118
103MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03212612
104BCL6_27268052_Chip-Seq_Bcells_Human1.02899216
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02243055
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01374891
107BCAT_22108803_ChIP-Seq_LS180_Human1.00010318
108SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99989461
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99287196
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98893304
111FOXA1_25552417_ChIP-Seq_VCAP_Human0.98230730
112TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98129898
113GATA1_19941826_ChIP-Seq_K562_Human0.98064970
114CJUN_26792858_Chip-Seq_BT549_Human0.98002078
115THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97053619
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96838583
117* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96548660
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.96310694
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96309360
120P300_27268052_Chip-Seq_Bcells_Human0.94440675
121REST_21632747_ChIP-Seq_MESCs_Mouse0.93496455
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93125069
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92952459
124ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92523995
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92373981
126LXR_22292898_ChIP-Seq_THP-1_Human0.92352542
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90790445
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90701741
129SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89981748
130KDM2B_26808549_Chip-Seq_K562_Human0.89976363
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89913687
132CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89747489
133TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89524995
134ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88972299
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88414762
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88410819
137STAT1_20625510_ChIP-Seq_HELA_Human0.88030200
138SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87941993
139GATA4_25053715_ChIP-Seq_YYC3_Human0.87692976
140OCT4_19829295_ChIP-Seq_ESCs_Human0.87617214
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87570278
142RUNX1_27514584_Chip-Seq_MCF-7_Human0.87442778
143MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87385925
144SMC4_20622854_ChIP-Seq_HELA_Human0.87013480
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.86618690
146MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85655550
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85497530
148DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85349246
149IGF1R_20145208_ChIP-Seq_DFB_Human0.84994972
150CDX2_22108803_ChIP-Seq_LS180_Human0.84055351
151GBX2_23144817_ChIP-Seq_PC3_Human0.82962840
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.82847183
153P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82366647
154CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80197116
155EZH2_18974828_ChIP-Seq_MESCs_Mouse0.78139953
156RNF2_18974828_ChIP-Seq_MESCs_Mouse0.78139953
157MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77881179
158VDR_24787735_ChIP-Seq_THP-1_Human0.77591772
159OCT4_20526341_ChIP-Seq_ESCs_Human0.77403013
160KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76212830
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76034695
162ESR1_20079471_ChIP-ChIP_T-47D_Human0.75387896
163TP63_23658742_ChIP-Seq_EP156T_Human0.74529159
164TP63_22573176_ChIP-Seq_HFKS_Human0.74168399
165RXR_22108803_ChIP-Seq_LS180_Human0.73939824
166ERG_20517297_ChIP-Seq_VCAP_Human0.73080716
167PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72701508
168RAC3_21632823_ChIP-Seq_H3396_Human0.72022816
169VDR_22108803_ChIP-Seq_LS180_Human0.71652769
170SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.71389706
171PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69669103
172CREB1_26743006_Chip-Seq_LNCaP_Human0.69462231
173SMAD4_21799915_ChIP-Seq_A2780_Human0.69379530
174NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68791544
175NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68791544
176FOXA1_21572438_ChIP-Seq_LNCaP_Human0.68038409
177HNF4A_19822575_ChIP-Seq_HepG2_Human0.67500406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.56929800
2MP0000566_synostosis3.84352049
3MP0005666_abnormal_adipose_tissue3.74931527
4MP0000013_abnormal_adipose_tissue3.67693123
5MP0004043_abnormal_pH_regulation3.53320781
6MP0002876_abnormal_thyroid_physiology3.42685771
7MP0005375_adipose_tissue_phenotype3.29591670
8MP0002837_dystrophic_cardiac_calcinosis3.13028782
9MP0000003_abnormal_adipose_tissue3.07197111
10MP0004130_abnormal_muscle_cell3.04073059
11MP0009379_abnormal_foot_pigmentation2.98983161
12MP0002653_abnormal_ependyma_morphology2.97799065
13MP0004185_abnormal_adipocyte_glucose2.81072392
14MP0010386_abnormal_urinary_bladder2.64318118
15MP0001984_abnormal_olfaction2.49873830
16MP0009780_abnormal_chondrocyte_physiolo2.45234917
17MP0008875_abnormal_xenobiotic_pharmacok2.36550326
18MP0003693_abnormal_embryo_hatching2.35309699
19MP0003195_calcinosis2.31190498
20MP0002909_abnormal_adrenal_gland2.23986452
21MP0002638_abnormal_pupillary_reflex2.19746011
22MP0001756_abnormal_urination2.14476359
23MP0002822_catalepsy2.10132365
24MP0005551_abnormal_eye_electrophysiolog2.08850629
25MP0001661_extended_life_span2.05238937
26MP0008438_abnormal_cutaneous_collagen2.04859540
27MP0009643_abnormal_urine_homeostasis2.00584136
28MP0002971_abnormal_brown_adipose1.99472067
29MP0000537_abnormal_urethra_morphology1.91062381
30MP0010329_abnormal_lipoprotein_level1.89036445
31MP0005334_abnormal_fat_pad1.86447340
32MP0004133_heterotaxia1.84629995
33MP0006072_abnormal_retinal_apoptosis1.82675527
34MP0003011_delayed_dark_adaptation1.81205381
35MP0005535_abnormal_body_temperature1.79794304
36MP0002877_abnormal_melanocyte_morpholog1.76725884
37MP0003959_abnormal_lean_body1.76353482
38MP0002160_abnormal_reproductive_system1.75852923
39MP0003283_abnormal_digestive_organ1.75679246
40MP0009115_abnormal_fat_cell1.75262678
41MP0002078_abnormal_glucose_homeostasis1.73210770
42MP0001944_abnormal_pancreas_morphology1.72799016
43MP0005058_abnormal_lysosome_morphology1.72765420
44MP0003315_abnormal_perineum_morphology1.71458086
45MP0001764_abnormal_homeostasis1.69294863
46MP0003191_abnormal_cellular_cholesterol1.67943352
47MP0002249_abnormal_larynx_morphology1.67310709
48MP0001765_abnormal_ion_homeostasis1.66600080
49MP0002234_abnormal_pharynx_morphology1.65423158
50MP0005360_urolithiasis1.65109200
51MP0005275_abnormal_skin_tensile1.63978974
52MP0004019_abnormal_vitamin_homeostasis1.63601903
53MP0002098_abnormal_vibrissa_morphology1.62689954
54MP0010030_abnormal_orbit_morphology1.62068627
55MP0002118_abnormal_lipid_homeostasis1.60286818
56MP0005253_abnormal_eye_physiology1.59904153
57MP0008789_abnormal_olfactory_epithelium1.59699531
58MP0005365_abnormal_bile_salt1.55675820
59MP0010678_abnormal_skin_adnexa1.55530837
60MP0005645_abnormal_hypothalamus_physiol1.54469979
61MP0002139_abnormal_hepatobiliary_system1.50539586
62MP0003718_maternal_effect1.49451312
63MP0005379_endocrine/exocrine_gland_phen1.47752433
64MP0001664_abnormal_digestion1.47201574
65MP0002693_abnormal_pancreas_physiology1.46900808
66MP0000383_abnormal_hair_follicle1.46858686
67MP0002970_abnormal_white_adipose1.42166856
68MP0005332_abnormal_amino_acid1.40660357
69MP0005499_abnormal_olfactory_system1.34743954
70MP0005394_taste/olfaction_phenotype1.34743954
71MP0001346_abnormal_lacrimal_gland1.31671651
72MP0002277_abnormal_respiratory_mucosa1.30027378
73MP0003300_gastrointestinal_ulcer1.29448226
74MP0002735_abnormal_chemical_nociception1.28471590
75MP0003045_fibrosis1.25881716
76MP0003937_abnormal_limbs/digits/tail_de1.25213142
77MP0000631_abnormal_neuroendocrine_gland1.24574534
78MP0004264_abnormal_extraembryonic_tissu1.21978088
79MP0008961_abnormal_basal_metabolism1.21292401
80MP0002736_abnormal_nociception_after1.21009195
81MP0002734_abnormal_mechanical_nocicepti1.19714644
82MP0001293_anophthalmia1.18132258
83MP0005448_abnormal_energy_balance1.17606081
84MP0005636_abnormal_mineral_homeostasis1.16234504
85MP0003186_abnormal_redox_activity1.16206152
86MP0003183_abnormal_peptide_metabolism1.15522485
87MP0010234_abnormal_vibrissa_follicle1.14586608
88MP0003953_abnormal_hormone_level1.14557708
89MP0008995_early_reproductive_senescence1.13438164
90MP0000538_abnormal_urinary_bladder1.13340688
91MP0002168_other_aberrant_phenotype1.13046746
92MP0005220_abnormal_exocrine_pancreas1.12101848
93MP0003252_abnormal_bile_duct1.11420506
94MP0000230_abnormal_systemic_arterial1.10066116
95MP0002896_abnormal_bone_mineralization1.09201089
96MP0001968_abnormal_touch/_nociception1.07818224
97MP0001873_stomach_inflammation1.07790914
98MP0004147_increased_porphyrin_level1.07783124
99MP0001485_abnormal_pinna_reflex1.06850473
100MP0004272_abnormal_basement_membrane1.05548567
101MP0010094_abnormal_chromosome_stability1.03713131
102MP0000778_abnormal_nervous_system1.03614552
103MP0003111_abnormal_nucleus_morphology1.03514373
104MP0005452_abnormal_adipose_tissue1.03423408
105MP0002136_abnormal_kidney_physiology1.03356455
106MP0003123_paternal_imprinting1.01610756
107MP0008057_abnormal_DNA_replication1.00916513
108MP0003119_abnormal_digestive_system1.00329726
109MP0000579_abnormal_nail_morphology1.00188197
110MP0003861_abnormal_nervous_system0.99863878
111MP0001188_hyperpigmentation0.98952191
112MP0001529_abnormal_vocalization0.98536470
113MP0002928_abnormal_bile_duct0.97477144
114MP0002138_abnormal_hepatobiliary_system0.95382124
115MP0002938_white_spotting0.94799797
116MP0000462_abnormal_digestive_system0.94157223
117MP0000609_abnormal_liver_physiology0.93657418
118MP0004957_abnormal_blastocyst_morpholog0.92536341
119MP0003698_abnormal_male_reproductive0.91897939
120MP0003705_abnormal_hypodermis_morpholog0.90646794
121MP0005389_reproductive_system_phenotype0.90419315
122MP0003136_yellow_coat_color0.90114177
123MP0003938_abnormal_ear_development0.89321221
124MP0003942_abnormal_urinary_system0.89208781
125MP0002233_abnormal_nose_morphology0.88016433
126MP0000681_abnormal_thyroid_gland0.87638227
127MP0008872_abnormal_physiological_respon0.86955132
128MP0002111_abnormal_tail_morphology0.86688241
129MP0001502_abnormal_circadian_rhythm0.85638790
130MP0002210_abnormal_sex_determination0.84541546
131MP0004270_analgesia0.83533723
132MP0000026_abnormal_inner_ear0.82911925
133MP0005195_abnormal_posterior_eye0.82578320
134MP0001929_abnormal_gametogenesis0.81237282
135MP0005501_abnormal_skin_physiology0.79580014
136MP0008932_abnormal_embryonic_tissue0.78449559
137MP0005319_abnormal_enzyme/_coenzyme0.78145499
138MP0002557_abnormal_social/conspecific_i0.77639717
139MP0002796_impaired_skin_barrier0.76689139
140MP0002116_abnormal_craniofacial_bone0.76206619
141MP0001145_abnormal_male_reproductive0.75889643
142MP0002132_abnormal_respiratory_system0.75799218
143MP0001727_abnormal_embryo_implantation0.75646658
144MP0000477_abnormal_intestine_morphology0.75459611
145MP0004742_abnormal_vestibular_system0.75068902
146MP0001324_abnormal_eye_pigmentation0.74958742
147MP0002084_abnormal_developmental_patter0.73736588
148MP0005395_other_phenotype0.73379766
149MP0002184_abnormal_innervation0.72473450
150MP0001501_abnormal_sleep_pattern0.72262181
151MP0001666_abnormal_nutrient_absorption0.71758660
152MP0005367_renal/urinary_system_phenotyp0.71519566
153MP0000516_abnormal_urinary_system0.71519566
154MP0003690_abnormal_glial_cell0.70482348
155MP0005620_abnormal_muscle_contractility0.70141303
156MP0001970_abnormal_pain_threshold0.69982253
157MP0005584_abnormal_enzyme/coenzyme_acti0.69978651
158MP0005377_hearing/vestibular/ear_phenot0.66961418
159MP0003878_abnormal_ear_physiology0.66961418
160MP0009672_abnormal_birth_weight0.65628941
161MP0002009_preneoplasia0.62570489
162MP0002229_neurodegeneration0.62567742
163MP0001958_emphysema0.62099425
164MP0002090_abnormal_vision0.61223869
165MP0001270_distended_abdomen0.61046917
166MP0002166_altered_tumor_susceptibility0.60575839
167MP0004858_abnormal_nervous_system0.59946994
168MP0005391_vision/eye_phenotype0.59817021
169MP0002295_abnormal_pulmonary_circulatio0.59137615
170MP0000678_abnormal_parathyroid_gland0.58589227
171MP0001881_abnormal_mammary_gland0.58468616
172MP0006036_abnormal_mitochondrial_physio0.57000545
173MP0002069_abnormal_eating/drinking_beha0.56530377
174MP0004782_abnormal_surfactant_physiolog0.53774302
175MP0009703_decreased_birth_body0.48929916

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.21652298
2Abnormal respiratory epithelium morphology (HP:0012253)7.31636575
3Abnormal respiratory motile cilium morphology (HP:0005938)7.31636575
4Dynein arm defect of respiratory motile cilia (HP:0012255)7.10895579
5Absent/shortened dynein arms (HP:0200106)7.10895579
6Abnormal respiratory motile cilium physiology (HP:0012261)7.03543179
7Abnormal ciliary motility (HP:0012262)6.83350575
8Rhinitis (HP:0012384)6.31568427
9Bony spicule pigmentary retinopathy (HP:0007737)5.37745601
10Ketoacidosis (HP:0001993)4.81237246
11Pigmentary retinal degeneration (HP:0001146)4.65920946
12Oligomenorrhea (HP:0000876)4.65211734
13Hyperglycinuria (HP:0003108)4.59088682
14Bronchiectasis (HP:0002110)4.46272526
15Abnormal rod and cone electroretinograms (HP:0008323)4.44428164
16Hypokalemic alkalosis (HP:0001949)4.14760635
17Central scotoma (HP:0000603)4.08552012
18Congenital stationary night blindness (HP:0007642)4.04749599
19Hyperactive renin-angiotensin system (HP:0000841)4.03724549
20Hypoglycemic coma (HP:0001325)4.03197577
21Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.91795674
22Nasal polyposis (HP:0100582)3.91407428
23Insulin-resistant diabetes mellitus (HP:0000831)3.88220297
24Abnormality of chloride homeostasis (HP:0011422)3.80482586
25Abnormality of macular pigmentation (HP:0008002)3.62255302
26Hypoglycemic seizures (HP:0002173)3.61414669
27Abnormality of serine family amino acid metabolism (HP:0010894)3.52942819
28Abnormality of glycine metabolism (HP:0010895)3.52942819
29Ketosis (HP:0001946)3.52418689
30Increased circulating renin level (HP:0000848)3.50457187
31Metabolic alkalosis (HP:0200114)3.50000007
32Hyperinsulinemic hypoglycemia (HP:0000825)3.44012596
33Pancreatic fibrosis (HP:0100732)3.35337720
34Acanthosis nigricans (HP:0000956)3.34407051
35Absent rod-and cone-mediated responses on ERG (HP:0007688)3.31376082
36Hypokalemia (HP:0002900)3.24242936
37Papilledema (HP:0001085)3.21488755
38Gout (HP:0001997)3.17433092
39Occipital encephalocele (HP:0002085)3.13779272
40Abnormal urine output (HP:0012590)3.10954230
41Polyuria (HP:0000103)3.06487680
42Cystic liver disease (HP:0006706)3.06308539
43Scotoma (HP:0000575)3.04019994
44Subcapsular cataract (HP:0000523)3.02692422
45Generalized aminoaciduria (HP:0002909)3.00540366
46Abnormality of purine metabolism (HP:0004352)3.00464228
47True hermaphroditism (HP:0010459)2.98791608
48Symptomatic seizures (HP:0011145)2.98577433
49Abnormality of renal excretion (HP:0011036)2.91471987
50Infertility (HP:0000789)2.90563441
51Chorioretinal atrophy (HP:0000533)2.90311887
52Hypomagnesemia (HP:0002917)2.89815473
53Abnormality of the nasal mucosa (HP:0000433)2.85079588
54Abnormality of midbrain morphology (HP:0002418)2.84473224
55Molar tooth sign on MRI (HP:0002419)2.84473224
56Hyperaldosteronism (HP:0000859)2.83400319
57Abnormality of potassium homeostasis (HP:0011042)2.82809275
58Abnormality of renin-angiotensin system (HP:0000847)2.82448476
59Insulin resistance (HP:0000855)2.80689480
60Abolished electroretinogram (ERG) (HP:0000550)2.80317635
61Proximal tubulopathy (HP:0000114)2.77359558
62Increased purine levels (HP:0004368)2.75697032
63Hyperuricemia (HP:0002149)2.75697032
64Hypertriglyceridemia (HP:0002155)2.74514010
65Pancreatic cysts (HP:0001737)2.72079700
66Polydipsia (HP:0001959)2.72035517
67Abnormal drinking behavior (HP:0030082)2.72035517
68Male infertility (HP:0003251)2.63677829
69Nephronophthisis (HP:0000090)2.63485850
70Hyperglycemia (HP:0003074)2.59985732
71Abnormality of calcium-phosphate metabolism (HP:0100530)2.56925036
72Hyperglycinemia (HP:0002154)2.56349147
73Facial diplegia (HP:0001349)2.52623773
74Abnormality of magnesium homeostasis (HP:0004921)2.52217450
75Dysostosis multiplex (HP:0000943)2.51423385
76Atelectasis (HP:0100750)2.49816566
77Type II diabetes mellitus (HP:0005978)2.48488059
78Progressive visual loss (HP:0000529)2.47620220
79Growth hormone excess (HP:0000845)2.46048286
80Complement deficiency (HP:0004431)2.39800036
81Abnormality of fatty-acid metabolism (HP:0004359)2.37948746
82Renal salt wasting (HP:0000127)2.37610898
83Retinal atrophy (HP:0001105)2.37004050
84Vacuolated lymphocytes (HP:0001922)2.36690542
85Postaxial foot polydactyly (HP:0001830)2.36379612
86Dyschromatopsia (HP:0007641)2.33448203
87Sclerocornea (HP:0000647)2.33145560
88Hypothermia (HP:0002045)2.30389942
89Hyperkalemia (HP:0002153)2.27948634
90Constricted visual fields (HP:0001133)2.27520599
91Urinary glycosaminoglycan excretion (HP:0003541)2.24308193
92Mucopolysacchariduria (HP:0008155)2.24308193
93Late onset (HP:0003584)2.22880623
94Decreased circulating renin level (HP:0003351)2.21682525
95Chronic hepatic failure (HP:0100626)2.19576908
96Abnormality of proline metabolism (HP:0010907)2.15947165
97Hydroxyprolinuria (HP:0003080)2.15947165
98Bronchitis (HP:0012387)2.15672163
99Attenuation of retinal blood vessels (HP:0007843)2.14671667
100Adrenal overactivity (HP:0002717)2.13282783
101Facial shape deformation (HP:0011334)2.12379276
102Potter facies (HP:0002009)2.12379276
103Chronic bronchitis (HP:0004469)2.12084390
104Abnormality of the renal medulla (HP:0100957)2.09825029
105Tetany (HP:0001281)2.08221461
106Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06781974
107Abnormality of polysaccharide metabolism (HP:0011012)2.06781974
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06781974
109Palpitations (HP:0001962)2.06151354
110Alkalosis (HP:0001948)2.05352859
111Myoglobinuria (HP:0002913)2.05167415
112Recurrent otitis media (HP:0000403)2.04642561
113Male pseudohermaphroditism (HP:0000037)2.04279547
114Chronic sinusitis (HP:0011109)2.02996186
115Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00912257
116Tachypnea (HP:0002789)1.99635451
117Testicular atrophy (HP:0000029)1.97366681
118Anencephaly (HP:0002323)1.96956585
119Tubular atrophy (HP:0000092)1.95507504
120Preaxial hand polydactyly (HP:0001177)1.94594094
121Aortic aneurysm (HP:0004942)1.92142201
122Hyperthyroidism (HP:0000836)1.91429641
123Polar cataract (HP:0010696)1.89428871
124Truncus arteriosus (HP:0001660)1.89153071
125Pili torti (HP:0003777)1.87445672
126Retinitis pigmentosa (HP:0000510)1.87192734
127Furrowed tongue (HP:0000221)1.86741877
128Bone cyst (HP:0012062)1.85040635
129Bifid scrotum (HP:0000048)1.84271001
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.84050595
131Pancreatitis (HP:0001733)1.83492444
132Tubulointerstitial fibrosis (HP:0005576)1.83197516
133Choroideremia (HP:0001139)1.82000806
134Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81029209
135Limb hypertonia (HP:0002509)1.80770144
136Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78907075
137Cone-rod dystrophy (HP:0000548)1.78866462
138Glucose intolerance (HP:0000833)1.78766740
139Long foot (HP:0001833)1.78551675
140Hand muscle atrophy (HP:0009130)1.78302976
141Recurrent sinusitis (HP:0011108)1.75454021
142Gait imbalance (HP:0002141)1.75299013
143Medial flaring of the eyebrow (HP:0010747)1.73651822
144Chromsome breakage (HP:0040012)1.70819502
145Reticulocytopenia (HP:0001896)1.70242023
146Congenital hepatic fibrosis (HP:0002612)1.69777339
147Tubulointerstitial nephritis (HP:0001970)1.68918435
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.66230192
149Congenital primary aphakia (HP:0007707)1.63872584
150Septate vagina (HP:0001153)1.63116380
151Broad distal phalanx of finger (HP:0009836)1.61594150
152Facial cleft (HP:0002006)1.60731842
153Hyponatremia (HP:0002902)1.57349900
154Microretrognathia (HP:0000308)1.56483051
155Polycystic kidney dysplasia (HP:0000113)1.54202258
156Hypoplasia of the capital femoral epiphysis (HP:0003090)1.53211501
157Asplenia (HP:0001746)1.51972519
158Oculomotor apraxia (HP:0000657)1.51613388
159Bell-shaped thorax (HP:0001591)1.49717774
160Abnormality of the 1st metacarpal (HP:0010009)1.48806704
161Postaxial hand polydactyly (HP:0001162)1.48530438
162Abnormality of the aortic arch (HP:0012303)1.47118288
163Abnormal hair laboratory examination (HP:0003328)1.47097568
164Poor coordination (HP:0002370)1.45784062
165Type II lissencephaly (HP:0007260)1.43819168
166Stridor (HP:0010307)1.43607575
167Cerebellar dysplasia (HP:0007033)1.42797689
168Short femoral neck (HP:0100864)1.41130413
169Nephrogenic diabetes insipidus (HP:0009806)1.39632636
170High anterior hairline (HP:0009890)1.39581437
171Hypoplasia of the uterus (HP:0000013)1.39349599
172Diaphragmatic weakness (HP:0009113)1.39214772
173Abnormality of cochlea (HP:0000375)1.39123795
174Optic nerve coloboma (HP:0000588)1.37735898
175Abnormality of the renal cortex (HP:0011035)1.37717816
176Abnormality of the dental root (HP:0006486)1.36904580
177Taurodontia (HP:0000679)1.36904580
178Abnormality of permanent molar morphology (HP:0011071)1.36904580
179Self-mutilation (HP:0000742)1.36001180
180Abnormality of the phalanges of the hallux (HP:0010057)1.35701865
181Abnormality of abdominal situs (HP:0011620)1.35481479
182Abdominal situs inversus (HP:0003363)1.35481479
183Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.32441220
184Hypoplasia of the pons (HP:0012110)1.31850940
185Aganglionic megacolon (HP:0002251)1.30848447
186Pendular nystagmus (HP:0012043)1.30497626
187Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.29775785
188Absent epiphyses (HP:0010577)1.29775785
189Holoprosencephaly (HP:0001360)1.29627846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.06105200
2INSRR4.50494997
3CAMK1D4.15841401
4WNK43.56697314
5BCKDK3.30391658
6FRK3.25439752
7TRIB33.21321743
8CAMK1G3.20042847
9WNK33.16797892
10SIK12.83433051
11PRKD32.55247627
12SMG12.53020161
13MAPK152.47882908
14TTK2.42215342
15NME12.17303838
16ERN12.07188200
17MYLK2.06628546
18ZAK1.91718880
19LMTK21.91456612
20PNCK1.85929340
21OXSR11.73444896
22TLK11.68770989
23SIK21.62801248
24RIPK11.60238571
25PRKCI1.58795361
26AKT31.54017046
27MAP3K21.47635702
28MST1R1.46638966
29LATS11.45432933
30MST41.43401324
31GRK11.42305658
32STK38L1.38345081
33HIPK21.36907661
34CHEK21.34883371
35PDGFRA1.33760534
36PDK31.33391240
37PDK41.33391240
38PRKAA21.32135865
39FER1.30003404
40PASK1.27431765
41TAOK31.25496657
42STK391.22835234
43CDK81.20208188
44CASK1.19649443
45BUB11.19236157
46BCR1.18834813
47PHKG11.17591297
48PHKG21.17591297
49FGFR31.17394466
50PBK1.15163488
51PDK21.08054477
52NTRK31.07847748
53PRKAA11.07280735
54WNK11.06472033
55BRSK21.06359733
56NEK21.06333598
57CDC71.04026872
58PIK3CG1.02389559
59PLK11.01824602
60RPS6KB21.01682530
61VRK21.01571583
62MAPKAPK31.01277867
63CAMKK20.99995512
64ATR0.97402587
65PRKCH0.97254246
66PKN20.96794242
67PAK30.96475444
68MAPK130.95694705
69AURKA0.93628044
70CDK70.91938694
71WEE10.88337109
72SGK4940.88266034
73SGK2230.88266034
74IRAK10.88206187
75CAMKK10.87827517
76TNIK0.86285704
77IRAK20.85525982
78MET0.84752838
79EPHA40.84278765
80PINK10.84000487
81IRAK30.81798377
82TNK20.80701216
83CDK90.79194350
84ERBB30.78160720
85FLT30.76807587
86MAP3K110.75666752
87FGFR20.75455974
88PRKD20.74812654
89BRSK10.74739436
90AURKB0.74524072
91SRPK10.73482663
92MAPKAPK50.73045420
93GSK3A0.71278386
94TRIM280.69999141
95SGK30.69847672
96TAOK10.67733172
97MAP3K60.67635896
98SGK20.65704269
99NUAK10.65257134
100SCYL20.64684608
101TTN0.63970599
102DYRK1B0.63302618
103PRKACG0.62072637
104RPS6KA20.61807974
105NTRK10.61258622
106ILK0.59227291
107MTOR0.59013434
108CHEK10.57726586
109STK380.57064498
110MAP3K30.57041819
111MARK10.56485247
112FGFR40.56043063
113MAP2K10.55534850
114CDC42BPA0.54571289
115EEF2K0.54274064
116CDK10.52921492
117PTK60.52730697
118LRRK20.52708486
119MAP2K60.52492508
120DAPK20.52434503
121DAPK10.51081437
122DDR20.50979943
123EPHA30.50475341
124CSNK1E0.49566482
125RPS6KA50.48953685
126TIE10.47630639
127AKT20.46992013
128TSSK60.46940543
129JAK20.46606140
130PDPK10.46458045
131NME20.45879548
132TGFBR20.45744558
133BMPR1B0.45702051
134MINK10.45475718
135MAP2K70.45110487
136MAP3K100.44519389
137JAK10.43458915
138MAP3K40.43348083
139PTK20.43046508
140NEK60.42554059
141ERBB20.41445503
142EIF2AK10.41066432
143CDK20.40895415
144PAK20.40081554
145PRKD10.39873625
146PRKCZ0.39390871
147RET0.38633202
148CDK120.37549133
149VRK10.37419841
150PIK3CA0.35493412
151CSNK1G30.35329137
152PRKDC0.35077703
153ATM0.34484514
154IGF1R0.34110320
155PDGFRB0.33746933
156DYRK20.33741013
157DMPK0.32814948
158EPHB20.32527488
159CSNK1A1L0.31195373
160MAPK110.31163995
161CSNK1A10.30559100
162MARK20.30541919
163INSR0.30170781
164CDK60.28865560
165GSK3B0.28468142
166ICK0.27243935
167PRKCE0.27016145
168MAP2K20.26783295
169RPS6KB10.25041759
170PRKACA0.22561515
171CAMK2D0.21825609

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.39192816
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.30018322
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.27362833
4Propanoate metabolism_Homo sapiens_hsa006403.14975723
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.05828995
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.05275165
7PPAR signaling pathway_Homo sapiens_hsa033202.76634675
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.64760338
9Fatty acid biosynthesis_Homo sapiens_hsa000612.39758833
10Sulfur metabolism_Homo sapiens_hsa009202.34520924
11Sulfur relay system_Homo sapiens_hsa041222.33601461
12Fatty acid metabolism_Homo sapiens_hsa012122.32908235
13Fatty acid degradation_Homo sapiens_hsa000712.24708993
14Glycerolipid metabolism_Homo sapiens_hsa005612.23998398
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02502229
16DNA replication_Homo sapiens_hsa030301.97961175
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90221932
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89449952
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84665601
20Pyruvate metabolism_Homo sapiens_hsa006201.81053352
21Chemical carcinogenesis_Homo sapiens_hsa052041.79563387
22Butanoate metabolism_Homo sapiens_hsa006501.71760298
23Huntingtons disease_Homo sapiens_hsa050161.68411048
24Base excision repair_Homo sapiens_hsa034101.67588687
25Olfactory transduction_Homo sapiens_hsa047401.62593577
26beta-Alanine metabolism_Homo sapiens_hsa004101.62437344
27ABC transporters_Homo sapiens_hsa020101.60898331
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55873227
29Peroxisome_Homo sapiens_hsa041461.54246274
30AMPK signaling pathway_Homo sapiens_hsa041521.48016038
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.44400861
32Ribosome_Homo sapiens_hsa030101.42978306
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42512041
34Fanconi anemia pathway_Homo sapiens_hsa034601.40466325
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36685075
36Tryptophan metabolism_Homo sapiens_hsa003801.35532053
37Homologous recombination_Homo sapiens_hsa034401.35366293
38Arginine and proline metabolism_Homo sapiens_hsa003301.33943589
39Mismatch repair_Homo sapiens_hsa034301.32124947
40Pyrimidine metabolism_Homo sapiens_hsa002401.30813741
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28515163
42Vitamin B6 metabolism_Homo sapiens_hsa007501.27706279
43Insulin resistance_Homo sapiens_hsa049311.27080455
44One carbon pool by folate_Homo sapiens_hsa006701.24556593
45Type II diabetes mellitus_Homo sapiens_hsa049301.21245546
46Protein export_Homo sapiens_hsa030601.20271674
47Insulin secretion_Homo sapiens_hsa049111.20036758
48Other glycan degradation_Homo sapiens_hsa005111.16095925
49Lysosome_Homo sapiens_hsa041421.15444304
50Nitrogen metabolism_Homo sapiens_hsa009101.13391596
51Fat digestion and absorption_Homo sapiens_hsa049751.13020742
52Biosynthesis of amino acids_Homo sapiens_hsa012301.12825429
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10149283
54RNA polymerase_Homo sapiens_hsa030201.08800571
55Protein digestion and absorption_Homo sapiens_hsa049741.08314337
56Phenylalanine metabolism_Homo sapiens_hsa003601.07235223
57Glucagon signaling pathway_Homo sapiens_hsa049221.06761715
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04166159
59Basal cell carcinoma_Homo sapiens_hsa052171.02839460
60Thyroid hormone synthesis_Homo sapiens_hsa049181.02811954
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.02025671
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01446148
63Nucleotide excision repair_Homo sapiens_hsa034200.99206435
64Carbon metabolism_Homo sapiens_hsa012000.98973829
65Hedgehog signaling pathway_Homo sapiens_hsa043400.98716864
66Folate biosynthesis_Homo sapiens_hsa007900.98578026
67Purine metabolism_Homo sapiens_hsa002300.98006318
68Vibrio cholerae infection_Homo sapiens_hsa051100.97568912
69Insulin signaling pathway_Homo sapiens_hsa049100.96742990
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94630538
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93163096
72Steroid biosynthesis_Homo sapiens_hsa001000.92764144
73Retinol metabolism_Homo sapiens_hsa008300.92714263
74Nicotine addiction_Homo sapiens_hsa050330.91718120
75Collecting duct acid secretion_Homo sapiens_hsa049660.85858411
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85651263
77Renin secretion_Homo sapiens_hsa049240.84908613
78Tyrosine metabolism_Homo sapiens_hsa003500.82948931
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80775637
80Metabolic pathways_Homo sapiens_hsa011000.80705703
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80617274
82Tight junction_Homo sapiens_hsa045300.78978601
83Starch and sucrose metabolism_Homo sapiens_hsa005000.75914057
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75642388
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74920270
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.73923698
87Cell cycle_Homo sapiens_hsa041100.73523167
88Oxidative phosphorylation_Homo sapiens_hsa001900.73485793
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71535146
90Arachidonic acid metabolism_Homo sapiens_hsa005900.70156997
91RNA transport_Homo sapiens_hsa030130.69546061
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69305708
93Lysine degradation_Homo sapiens_hsa003100.67513312
94Notch signaling pathway_Homo sapiens_hsa043300.67075599
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66842545
96Spliceosome_Homo sapiens_hsa030400.64973991
97N-Glycan biosynthesis_Homo sapiens_hsa005100.64655144
98Bile secretion_Homo sapiens_hsa049760.64028889
99Ovarian steroidogenesis_Homo sapiens_hsa049130.63125060
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60914516
101Ether lipid metabolism_Homo sapiens_hsa005650.59982470
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.59105553
103Hippo signaling pathway_Homo sapiens_hsa043900.58965992
104Cocaine addiction_Homo sapiens_hsa050300.58209783
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57796083
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57573171
107Fructose and mannose metabolism_Homo sapiens_hsa000510.56349214
108Selenocompound metabolism_Homo sapiens_hsa004500.55600188
109Non-homologous end-joining_Homo sapiens_hsa034500.54309593
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.53434299
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52442259
112cAMP signaling pathway_Homo sapiens_hsa040240.52124016
113Fatty acid elongation_Homo sapiens_hsa000620.51980982
114mRNA surveillance pathway_Homo sapiens_hsa030150.51583900
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51087156
116Vitamin digestion and absorption_Homo sapiens_hsa049770.50522851
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49140398
118Synaptic vesicle cycle_Homo sapiens_hsa047210.46698540
119Gastric acid secretion_Homo sapiens_hsa049710.46685889
120Sphingolipid metabolism_Homo sapiens_hsa006000.46058041
121Circadian rhythm_Homo sapiens_hsa047100.43891896
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.43665824
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41094240
124Pancreatic secretion_Homo sapiens_hsa049720.38540489
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.38154586
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35619760
127Taste transduction_Homo sapiens_hsa047420.34159013
128ECM-receptor interaction_Homo sapiens_hsa045120.33565825
129mTOR signaling pathway_Homo sapiens_hsa041500.33362748
130Caffeine metabolism_Homo sapiens_hsa002320.33281693
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33162094
132Linoleic acid metabolism_Homo sapiens_hsa005910.32980539
133Renin-angiotensin system_Homo sapiens_hsa046140.31864112
134Glutathione metabolism_Homo sapiens_hsa004800.31747893
135Histidine metabolism_Homo sapiens_hsa003400.31157619
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30896676
137Dopaminergic synapse_Homo sapiens_hsa047280.30785834
138Mineral absorption_Homo sapiens_hsa049780.29693962
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29568183
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28737847
141Cholinergic synapse_Homo sapiens_hsa047250.28578887
142Salivary secretion_Homo sapiens_hsa049700.26951775
143Prion diseases_Homo sapiens_hsa050200.24263336
144Galactose metabolism_Homo sapiens_hsa000520.23511815
145Arginine biosynthesis_Homo sapiens_hsa002200.23500631
146Pentose phosphate pathway_Homo sapiens_hsa000300.22708315
147Focal adhesion_Homo sapiens_hsa045100.21732440
148Inositol phosphate metabolism_Homo sapiens_hsa005620.20035369

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