GLB1L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1artery development (GO:0060840)9.03900675
2regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)8.56335045
3prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060528.54168887
4mannose metabolic process (GO:0006013)7.92639767
5fucose catabolic process (GO:0019317)7.71678022
6L-fucose metabolic process (GO:0042354)7.71678022
7L-fucose catabolic process (GO:0042355)7.71678022
8prostate gland epithelium morphogenesis (GO:0060740)7.61989142
9mitotic cell cycle arrest (GO:0071850)7.15263860
10positive regulation of steroid hormone secretion (GO:2000833)7.06274767
11regulation of receptor binding (GO:1900120)6.89068006
12Golgi transport vesicle coating (GO:0048200)6.61920475
13COPI coating of Golgi vesicle (GO:0048205)6.61920475
14ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)6.37435967
15response to testosterone (GO:0033574)6.33986667
16valine metabolic process (GO:0006573)6.25214123
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.01575831
18N-glycan processing (GO:0006491)5.77120288
19fucose metabolic process (GO:0006004)5.73597079
20activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.58972988
21epithelial cell differentiation involved in prostate gland development (GO:0060742)5.56178898
22galactose catabolic process (GO:0019388)5.42328901
23positive regulation of growth hormone secretion (GO:0060124)5.35083003
24positive regulation of nuclease activity (GO:0032075)5.32919881
25activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)5.28020846
26pharyngeal system development (GO:0060037)5.08979946
27potassium ion homeostasis (GO:0055075)4.94587381
28regulation of nuclease activity (GO:0032069)4.82658653
29hormone catabolic process (GO:0042447)4.79686631
30regulation of steroid hormone secretion (GO:2000831)4.75481634
31endoplasmic reticulum unfolded protein response (GO:0030968)4.69720844
32lung secretory cell differentiation (GO:0061140)4.65914965
33epithelial cell maturation (GO:0002070)4.65576356
34protein retention in ER lumen (GO:0006621)4.64574591
35cellular response to unfolded protein (GO:0034620)4.56410183
36regulation of gene silencing by RNA (GO:0060966)4.53742961
37regulation of posttranscriptional gene silencing (GO:0060147)4.53742961
38regulation of gene silencing by miRNA (GO:0060964)4.53742961
39positive regulation of natural killer cell differentiation (GO:0032825)4.51855085
40behavioral response to nicotine (GO:0035095)4.44909976
41intestinal epithelial cell development (GO:0060576)4.41964772
42ER-nucleus signaling pathway (GO:0006984)4.32280227
43apoptotic cell clearance (GO:0043277)4.32164458
44positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)4.30934842
45cellular response to topologically incorrect protein (GO:0035967)4.30034299
46positive regulation of catenin import into nucleus (GO:0035413)4.29379439
47response to endoplasmic reticulum stress (GO:0034976)4.27931873
48pyrimidine-containing compound transmembrane transport (GO:0072531)4.25845246
49regulation of growth hormone secretion (GO:0060123)4.16803505
50positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.16022054
512-oxoglutarate metabolic process (GO:0006103)4.04522727
52negative regulation of DNA-dependent DNA replication (GO:2000104)4.01547877
53retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.00208340
54COPII vesicle coating (GO:0048208)3.97260183
55regulation of nuclear cell cycle DNA replication (GO:0033262)3.96771743
56intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.88442269
57negative regulation of cholesterol transport (GO:0032375)3.86166583
58negative regulation of sterol transport (GO:0032372)3.86166583
59fucosylation (GO:0036065)3.85397075
60vitamin transmembrane transport (GO:0035461)3.83274015
61negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.81382941
62negative regulation of translation, ncRNA-mediated (GO:0040033)3.81382941
63regulation of translation, ncRNA-mediated (GO:0045974)3.81382941
64UDP-N-acetylglucosamine metabolic process (GO:0006047)3.81007985
65regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.78933217
66sulfur amino acid catabolic process (GO:0000098)3.74704805
67protein autoprocessing (GO:0016540)3.72489125
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.71621221
69regulation of mitotic spindle checkpoint (GO:1903504)3.71621221
70protein N-linked glycosylation via asparagine (GO:0018279)3.70335939
71peptidyl-asparagine modification (GO:0018196)3.69445761
72negative regulation of telomere maintenance (GO:0032205)3.67326513
73DNA deamination (GO:0045006)3.66212302
74water-soluble vitamin biosynthetic process (GO:0042364)3.64503600
75cellular modified amino acid catabolic process (GO:0042219)3.61463892
76hexose catabolic process (GO:0019320)3.61419921
77oxaloacetate metabolic process (GO:0006107)3.58707599
78glandular epithelial cell differentiation (GO:0002067)3.58595916
79response to unfolded protein (GO:0006986)3.58462245
80macroautophagy (GO:0016236)3.53770531
81negative regulation of erythrocyte differentiation (GO:0045647)3.51879719
82respiratory chain complex IV assembly (GO:0008535)3.49520588
83protein kinase B signaling (GO:0043491)3.49065727
84regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.47968223
85branched-chain amino acid metabolic process (GO:0009081)3.47702885
86GDP-mannose metabolic process (GO:0019673)3.46759490
87angiotensin maturation (GO:0002003)3.46750098
88DNA double-strand break processing (GO:0000729)3.44950500
89response to topologically incorrect protein (GO:0035966)3.41183325
90antigen processing and presentation via MHC class Ib (GO:0002475)3.40421290
91somatic hypermutation of immunoglobulin genes (GO:0016446)3.39249706
92somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39249706
93protein N-linked glycosylation (GO:0006487)3.37363000
94vesicle coating (GO:0006901)3.33185732
95mammary gland alveolus development (GO:0060749)3.29790239
96protein targeting to Golgi (GO:0000042)3.28967569
97zinc ion transport (GO:0006829)3.28217802
98regulation of gonadotropin secretion (GO:0032276)3.25233543
99ER overload response (GO:0006983)3.23566358
100pseudouridine synthesis (GO:0001522)3.19271482
101galactose metabolic process (GO:0006012)3.18637788
102nucleotide-sugar biosynthetic process (GO:0009226)3.16420925
103kynurenine metabolic process (GO:0070189)3.15933250
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14042316
105reciprocal meiotic recombination (GO:0007131)3.13943028
106reciprocal DNA recombination (GO:0035825)3.13943028
107replication fork processing (GO:0031297)3.13134932
108cytochrome complex assembly (GO:0017004)3.08256943
109response to pheromone (GO:0019236)3.06144098
110regulation of endocrine process (GO:0044060)3.05205248
111positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.04704447
112establishment of protein localization to Golgi (GO:0072600)3.04237209
113glycerophospholipid catabolic process (GO:0046475)3.03719016
114calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.03581235
115regulation of telomere maintenance (GO:0032204)3.02505875
116regulation of protein glycosylation (GO:0060049)3.02212211
117sequestering of metal ion (GO:0051238)3.01980088
118synapsis (GO:0007129)3.01372065
119RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.00706172
120recombinational repair (GO:0000725)2.99958426
121double-strand break repair via homologous recombination (GO:0000724)2.99594191
122regulation of meiosis I (GO:0060631)2.97679312
123regulation of clathrin-mediated endocytosis (GO:2000369)2.97116761
124chromatin remodeling at centromere (GO:0031055)2.96819120
125indolalkylamine metabolic process (GO:0006586)2.95490236
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94551120
127retrograde transport, vesicle recycling within Golgi (GO:0000301)2.93392299
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93118038
129creatine metabolic process (GO:0006600)2.92194856
130monosaccharide catabolic process (GO:0046365)2.90546026
131transcytosis (GO:0045056)2.89581764
132telomere maintenance via telomerase (GO:0007004)2.89057867
133regulation of polysaccharide biosynthetic process (GO:0032885)2.88944161
134regulation of telomere maintenance via telomerase (GO:0032210)2.88120783
135mitochondrial respiratory chain complex assembly (GO:0033108)2.87380693
136beta-amyloid metabolic process (GO:0050435)2.86657078
137protein complex biogenesis (GO:0070271)2.85888214
138regulation of helicase activity (GO:0051095)2.85465867
139L-serine transport (GO:0015825)2.85238115
140negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.84616511
141transcription elongation from RNA polymerase III promoter (GO:0006385)2.83846357
142termination of RNA polymerase III transcription (GO:0006386)2.83846357
143chaperone-mediated protein transport (GO:0072321)2.82272487
144tryptophan catabolic process (GO:0006569)2.81421342
145indole-containing compound catabolic process (GO:0042436)2.81421342
146indolalkylamine catabolic process (GO:0046218)2.81421342
147DNA replication checkpoint (GO:0000076)2.76115690
148kidney morphogenesis (GO:0060993)2.75697798
149mitochondrial RNA metabolic process (GO:0000959)2.72185347
150mitochondrial respiratory chain complex I assembly (GO:0032981)2.72020749
151NADH dehydrogenase complex assembly (GO:0010257)2.72020749
152mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72020749
153photoreceptor cell maintenance (GO:0045494)2.71485537
154CENP-A containing nucleosome assembly (GO:0034080)2.70062668
155histone exchange (GO:0043486)2.69901032
156protein K6-linked ubiquitination (GO:0085020)2.69481271
157ncRNA catabolic process (GO:0034661)2.67968158
158DNA replication-dependent nucleosome assembly (GO:0006335)2.67417334
159DNA replication-dependent nucleosome organization (GO:0034723)2.67417334
160regulation of hippo signaling (GO:0035330)2.66476591
161reflex (GO:0060004)2.65928400
162piRNA metabolic process (GO:0034587)2.64365340
163negative regulation of telomerase activity (GO:0051974)2.63454133
164G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62577311
165protein neddylation (GO:0045116)2.62570908
166L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61052940
167retinal cone cell development (GO:0046549)2.59276174
168maturation of 5.8S rRNA (GO:0000460)2.57044851
169rRNA catabolic process (GO:0016075)2.55979417
170sulfation (GO:0051923)2.54107906
171detection of light stimulus involved in sensory perception (GO:0050962)2.54033859
172detection of light stimulus involved in visual perception (GO:0050908)2.54033859
173peptidyl-histidine modification (GO:0018202)2.53863182
174gamma-aminobutyric acid transport (GO:0015812)2.53244878
175maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.50618812
176centriole replication (GO:0007099)2.50321519
177tryptophan metabolic process (GO:0006568)2.47662849
178atrial cardiac muscle cell action potential (GO:0086014)2.46861104
179isotype switching (GO:0045190)2.45891287
180somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.45891287
181somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.45891287
182protein-cofactor linkage (GO:0018065)2.45020455
183establishment of protein localization to mitochondrial membrane (GO:0090151)2.44777043
184regulation of DNA endoreduplication (GO:0032875)2.43742996
185RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43203461
186tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43203461
187negative regulation of DNA recombination (GO:0045910)2.40422790
188histone mRNA metabolic process (GO:0008334)2.38068647
189DNA methylation involved in gamete generation (GO:0043046)2.37977573
190mannosylation (GO:0097502)2.37767635
191indole-containing compound metabolic process (GO:0042430)2.37654015
192mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.36931682
193cellular ketone body metabolic process (GO:0046950)2.36923309
194tRNA processing (GO:0008033)2.36517044
195regulation of rhodopsin mediated signaling pathway (GO:0022400)2.35781520
196protein K11-linked deubiquitination (GO:0035871)2.34948801
197branching involved in prostate gland morphogenesis (GO:0060442)12.1972993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.44255257
2ZNF263_19887448_ChIP-Seq_K562_Human3.32377934
3VDR_22108803_ChIP-Seq_LS180_Human3.29582958
4GATA1_22025678_ChIP-Seq_K562_Human3.25784606
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.24519882
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.22288493
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.96003801
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.96003801
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.96003801
10AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.93964414
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88309679
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86339729
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.85559198
14GBX2_23144817_ChIP-Seq_PC3_Human2.74725144
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.62687116
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62333394
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.52450890
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49981028
19IGF1R_20145208_ChIP-Seq_DFB_Human2.49784036
20FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.47725206
21CLOCK_20551151_ChIP-Seq_293T_Human2.46284503
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42286681
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.35080190
24EWS_26573619_Chip-Seq_HEK293_Human2.34955134
25SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.31913621
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26868336
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24056719
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22246335
29FUS_26573619_Chip-Seq_HEK293_Human2.19769359
30POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17793887
31ZNF217_24962896_ChIP-Seq_MCF-7_Human2.17111610
32P300_19829295_ChIP-Seq_ESCs_Human2.12653471
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11136590
34PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10624859
35CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08060063
36AHR_22903824_ChIP-Seq_MCF-7_Human2.07491039
37ESR1_21235772_ChIP-Seq_MCF-7_Human2.06784197
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.02263447
39FOXO3_23340844_ChIP-Seq_DLD1_Human2.00467047
40TAF15_26573619_Chip-Seq_HEK293_Human1.99167002
41SOX2_20726797_ChIP-Seq_SW620_Human1.97790073
42EZH2_22144423_ChIP-Seq_EOC_Human1.97607003
43* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91946714
44ZNF274_21170338_ChIP-Seq_K562_Hela1.87991583
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.87238107
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.85733790
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84352303
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.83999271
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83635842
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.82259669
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76090060
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.75923988
53MYC_18940864_ChIP-ChIP_HL60_Human1.70375655
54CHD1_26751641_Chip-Seq_LNCaP_Human1.69595050
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.69280669
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.67668983
57ER_23166858_ChIP-Seq_MCF-7_Human1.66875196
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66041540
59GATA6_25053715_ChIP-Seq_YYC3_Human1.65954642
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63760345
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63708431
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60588176
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.59836813
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57703400
65IRF1_19129219_ChIP-ChIP_H3396_Human1.57672361
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.56409874
67CREB1_26743006_Chip-Seq_LNCaP_Human1.55810961
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54279990
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53985901
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53827279
71E2F7_22180533_ChIP-Seq_HELA_Human1.53230461
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52655065
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.52593939
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51716298
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51167960
76GATA4_25053715_ChIP-Seq_YYC3_Human1.50070308
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49977143
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49952106
79ELK1_19687146_ChIP-ChIP_HELA_Human1.49608083
80BCAT_22108803_ChIP-Seq_LS180_Human1.48746551
81GATA3_24758297_ChIP-Seq_MCF-7_Human1.47255435
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47122133
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47122133
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46945995
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45254814
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45151706
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42092432
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.42077602
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41981013
90STAT3_23295773_ChIP-Seq_U87_Human1.41835362
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41606575
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.41327010
93TP53_22127205_ChIP-Seq_IMR90_Human1.41311517
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.39982354
95CBP_20019798_ChIP-Seq_JUKART_Human1.38825619
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38825619
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37091835
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37091835
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35870819
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35524575
101TCF4_23295773_ChIP-Seq_U87_Human1.35437029
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35345010
103* FOXA1_25552417_ChIP-Seq_VCAP_Human1.34483289
104TP53_22573176_ChIP-Seq_HFKS_Human1.34230840
105NANOG_19829295_ChIP-Seq_ESCs_Human1.34218794
106SOX2_19829295_ChIP-Seq_ESCs_Human1.34218794
107SMAD4_21799915_ChIP-Seq_A2780_Human1.33166596
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32742360
109VDR_23849224_ChIP-Seq_CD4+_Human1.30525949
110TP63_17297297_ChIP-ChIP_HaCaT_Human1.29366873
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28411048
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28103314
113TCF4_22108803_ChIP-Seq_LS180_Human1.26086677
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25032729
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.24290819
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22578478
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21774422
118AR_25329375_ChIP-Seq_VCAP_Human1.21367542
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21180055
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21031417
121RUNX2_22187159_ChIP-Seq_PCA_Human1.18350483
122* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17613882
123* FOXA1_25329375_ChIP-Seq_VCAP_Human1.17613882
124REST_21632747_ChIP-Seq_MESCs_Mouse1.17516986
125ATF3_27146783_Chip-Seq_COLON_Human1.17060900
126AR_21909140_ChIP-Seq_LNCAP_Human1.16576541
127CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15527931
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15336075
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15252147
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14565599
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14490709
132NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13683896
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13683896
134* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.13375238
135FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13304080
136IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13074207
137CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11547434
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11456894
139FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11283094
140PIAS1_25552417_ChIP-Seq_VCAP_Human1.10706902
141SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10444929
142RACK7_27058665_Chip-Seq_MCF-7_Human1.10329051
143SOX2_16153702_ChIP-ChIP_HESCs_Human1.10249266
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09275048
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09244815
146SMAD4_21741376_ChIP-Seq_EPCs_Human1.08184543
147ETS1_20019798_ChIP-Seq_JURKAT_Human1.07874189
148TRIM28_21343339_ChIP-Seq_HEK293_Human1.07827963
149CRX_20693478_ChIP-Seq_RETINA_Mouse1.07457225
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06725131
151BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05795771
152AR_21572438_ChIP-Seq_LNCaP_Human1.05468069
153CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04300850
154NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03938730
155NANOG_18555785_Chip-Seq_ESCs_Mouse1.03644860
156OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02966671
157EP300_21415370_ChIP-Seq_HL-1_Mouse1.02653394
158FOXP3_21729870_ChIP-Seq_TREG_Human1.02267403
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02081058
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01990252
161CDX2_20551321_ChIP-Seq_CACO-2_Human1.01875932
162FLI1_21867929_ChIP-Seq_TH2_Mouse1.01487281
163AR_20517297_ChIP-Seq_VCAP_Human1.00847741
164TBX20_22080862_ChIP-Seq_HEART_Mouse1.00082560
165TBX20_22328084_ChIP-Seq_HEART_Mouse1.00082560
166BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99866365
167P53_22387025_ChIP-Seq_ESCs_Mouse0.99865583
168PRDM14_20953172_ChIP-Seq_ESCs_Human0.99507859
169NCOR_22424771_ChIP-Seq_293T_Human0.99098773
170* HOXB7_26014856_ChIP-Seq_BT474_Human0.99087498
171STAT3_18555785_Chip-Seq_ESCs_Mouse0.98572258
172ELF5_23300383_ChIP-Seq_T47D_Human0.98375778
173EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98268703
174SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97197892
175ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95363294
176P300_18555785_Chip-Seq_ESCs_Mouse0.95221121
177FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94894404
178* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94741777
179PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94230803
180PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93949539
181CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93303422
182PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92149878
183HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91120987
184SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89777106
185ISL1_27105846_Chip-Seq_CPCs_Mouse0.89050837
186GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88165424
187ERG_20517297_ChIP-Seq_VCAP_Human0.87515575
188P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87180503
189NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87101900
190CDX2_22108803_ChIP-Seq_LS180_Human0.85930874
191PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85684480
192YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85207451
193FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84201726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005310_abnormal_salivary_gland5.71293801
2MP0004043_abnormal_pH_regulation5.47163715
3MP0002166_altered_tumor_susceptibility5.29316520
4MP0003300_gastrointestinal_ulcer5.08432348
5MP0005647_abnormal_sex_gland5.01590129
6MP0010234_abnormal_vibrissa_follicle4.79384407
7MP0008877_abnormal_DNA_methylation4.67157691
8MP0002006_tumorigenesis3.82616504
9MP0000613_abnormal_salivary_gland3.42811926
10MP0001765_abnormal_ion_homeostasis3.05936747
11MP0010386_abnormal_urinary_bladder2.72588535
12MP0001756_abnormal_urination2.61903735
13MP0008057_abnormal_DNA_replication2.56319737
14MP0003787_abnormal_imprinting2.53704065
15MP0008058_abnormal_DNA_repair2.51953148
16MP0001873_stomach_inflammation2.47709883
17MP0003195_calcinosis2.46884779
18MP0006292_abnormal_olfactory_placode2.42149488
19MP0002132_abnormal_respiratory_system2.40875843
20MP0002254_reproductive_system_inflammat2.39623782
21MP0000537_abnormal_urethra_morphology2.34760336
22MP0002736_abnormal_nociception_after2.30106503
23MP0002139_abnormal_hepatobiliary_system2.29970321
24MP0003136_yellow_coat_color2.28804817
25MP0009764_decreased_sensitivity_to2.27549846
26MP0001968_abnormal_touch/_nociception2.24614258
27MP0003656_abnormal_erythrocyte_physiolo2.22193327
28MP0005058_abnormal_lysosome_morphology2.21518722
29MP0005551_abnormal_eye_electrophysiolog2.18261092
30MP0005636_abnormal_mineral_homeostasis2.08781447
31MP0002102_abnormal_ear_morphology2.05103822
32MP0003718_maternal_effect2.04100072
33MP0003183_abnormal_peptide_metabolism2.03445833
34MP0010094_abnormal_chromosome_stability1.89870903
35MP0009745_abnormal_behavioral_response1.87864635
36MP0009046_muscle_twitch1.87102557
37MP0002837_dystrophic_cardiac_calcinosis1.85432520
38MP0008872_abnormal_physiological_respon1.77855155
39MP0003646_muscle_fatigue1.76120644
40MP0003693_abnormal_embryo_hatching1.75458146
41MP0002163_abnormal_gland_morphology1.74372977
42MP0001485_abnormal_pinna_reflex1.72586330
43MP0001188_hyperpigmentation1.68960291
44MP0002295_abnormal_pulmonary_circulatio1.67628219
45MP0009765_abnormal_xenobiotic_induced1.67076340
46MP0005332_abnormal_amino_acid1.66161034
47MP0004264_abnormal_extraembryonic_tissu1.66118006
48MP0003011_delayed_dark_adaptation1.64916187
49MP0009780_abnormal_chondrocyte_physiolo1.62379599
50MP0009643_abnormal_urine_homeostasis1.61619922
51MP0005253_abnormal_eye_physiology1.61097622
52MP0005645_abnormal_hypothalamus_physiol1.59482528
53MP0001529_abnormal_vocalization1.59387538
54MP0003866_abnormal_defecation1.57527350
55MP0003880_abnormal_central_pattern1.57163522
56MP0005379_endocrine/exocrine_gland_phen1.56889883
57MP0001984_abnormal_olfaction1.55000070
58MP0002938_white_spotting1.53830833
59MP0002272_abnormal_nervous_system1.50477262
60MP0001501_abnormal_sleep_pattern1.48829026
61MP0003941_abnormal_skin_development1.48726383
62MP0005646_abnormal_pituitary_gland1.47151467
63MP0003121_genomic_imprinting1.47077613
64MP0010352_gastrointestinal_tract_polyps1.46789267
65MP0004133_heterotaxia1.42940441
66MP0000631_abnormal_neuroendocrine_gland1.39010292
67MP0006276_abnormal_autonomic_nervous1.38479275
68MP0002136_abnormal_kidney_physiology1.38068101
69MP0001486_abnormal_startle_reflex1.37358644
70MP0002638_abnormal_pupillary_reflex1.33202499
71MP0004142_abnormal_muscle_tone1.31808501
72MP0005220_abnormal_exocrine_pancreas1.31693927
73MP0002876_abnormal_thyroid_physiology1.28864622
74MP0001293_anophthalmia1.22857548
75MP0000372_irregular_coat_pigmentation1.22446656
76MP0005166_decreased_susceptibility_to1.22379152
77MP0002009_preneoplasia1.22022168
78MP0002064_seizures1.21836789
79MP0005410_abnormal_fertilization1.20359735
80MP0000427_abnormal_hair_cycle1.20328939
81MP0003705_abnormal_hypodermis_morpholog1.20136747
82MP0000534_abnormal_ureter_morphology1.18427446
83MP0004134_abnormal_chest_morphology1.17899088
84MP0000569_abnormal_digit_pigmentation1.16610240
85MP0001299_abnormal_eye_distance/1.16588527
86MP0002653_abnormal_ependyma_morphology1.16357665
87MP0004885_abnormal_endolymph1.15106922
88MP0001986_abnormal_taste_sensitivity1.13171937
89MP0003111_abnormal_nucleus_morphology1.11210598
90MP0003119_abnormal_digestive_system1.09297669
91MP0004742_abnormal_vestibular_system1.09135353
92MP0003045_fibrosis1.08215371
93MP0002572_abnormal_emotion/affect_behav1.08112410
94MP0003937_abnormal_limbs/digits/tail_de1.06835726
95MP0010155_abnormal_intestine_physiology1.05788307
96MP0000538_abnormal_urinary_bladder1.05021870
97MP0003635_abnormal_synaptic_transmissio1.04750287
98MP0002160_abnormal_reproductive_system1.04616202
99MP0005389_reproductive_system_phenotype1.04110477
100MP0002396_abnormal_hematopoietic_system1.03633400
101MP0002735_abnormal_chemical_nociception1.02304511
102MP0002733_abnormal_thermal_nociception1.00747843
103MP0005075_abnormal_melanosome_morpholog0.99569331
104MP0008007_abnormal_cellular_replicative0.99173444
105MP0001970_abnormal_pain_threshold0.99068035
106MP0010678_abnormal_skin_adnexa0.98600674
107MP0000230_abnormal_systemic_arterial0.96318305
108MP0002210_abnormal_sex_determination0.96238520
109MP0002751_abnormal_autonomic_nervous0.96140944
110MP0004924_abnormal_behavior0.95811779
111MP0005386_behavior/neurological_phenoty0.95811779
112MP0004957_abnormal_blastocyst_morpholog0.95600222
113MP0003122_maternal_imprinting0.95366154
114MP0005174_abnormal_tail_pigmentation0.94817676
115MP0005319_abnormal_enzyme/_coenzyme0.94619495
116MP0001929_abnormal_gametogenesis0.94503626
117MP0002067_abnormal_sensory_capabilities0.94016708
118MP0002557_abnormal_social/conspecific_i0.93336114
119MP0002734_abnormal_mechanical_nocicepti0.92041337
120MP0008875_abnormal_xenobiotic_pharmacok0.91996112
121MP0002135_abnormal_kidney_morphology0.91749626
122MP0003786_premature_aging0.91726070
123MP0002063_abnormal_learning/memory/cond0.90860370
124MP0003567_abnormal_fetal_cardiomyocyte0.90629384
125MP0001919_abnormal_reproductive_system0.89511147
126MP0002909_abnormal_adrenal_gland0.88946131
127MP0003315_abnormal_perineum_morphology0.88461149
128MP0003638_abnormal_response/metabolism_0.88411766
129MP0000767_abnormal_smooth_muscle0.87690958
130MP0005076_abnormal_cell_differentiation0.86603561
131MP0006054_spinal_hemorrhage0.86436742
132MP0003186_abnormal_redox_activity0.85541444
133MP0000383_abnormal_hair_follicle0.85303001
134MP0009384_cardiac_valve_regurgitation0.85065283
135MP0000653_abnormal_sex_gland0.84125122
136MP0004215_abnormal_myocardial_fiber0.82476963
137MP0001145_abnormal_male_reproductive0.82444589
138MP0002277_abnormal_respiratory_mucosa0.81429460
139MP0006035_abnormal_mitochondrial_morpho0.81249556
140MP0008995_early_reproductive_senescence0.81054574
141MP0005195_abnormal_posterior_eye0.80196747
142MP0005023_abnormal_wound_healing0.78355432
143MP0005187_abnormal_penis_morphology0.77721836
144MP0000647_abnormal_sebaceous_gland0.75990292
145MP0002752_abnormal_somatic_nervous0.75350670
146MP0003936_abnormal_reproductive_system0.74883413
147MP0001944_abnormal_pancreas_morphology0.74757468
148MP0008438_abnormal_cutaneous_collagen0.74445322
149MP0000343_altered_response_to0.73879945
150MP0005377_hearing/vestibular/ear_phenot0.73823807
151MP0003878_abnormal_ear_physiology0.73823807
152MP0002184_abnormal_innervation0.73407769
153MP0002111_abnormal_tail_morphology0.72210991
154MP0000627_abnormal_mammary_gland0.71540930
155MP0003959_abnormal_lean_body0.71031074
156MP0005365_abnormal_bile_salt0.68029699
157MP0003566_abnormal_cell_adhesion0.67390682
158MP0004185_abnormal_adipocyte_glucose0.66846006
159MP0002796_impaired_skin_barrier0.66621392
160MP0002896_abnormal_bone_mineralization0.66049307
161MP0004145_abnormal_muscle_electrophysio0.65188455
162MP0001666_abnormal_nutrient_absorption0.64394930
163MP0000681_abnormal_thyroid_gland0.63312018
164MP0001764_abnormal_homeostasis0.63311519
165MP0001346_abnormal_lacrimal_gland0.63012194
166MP0001663_abnormal_digestive_system0.61015797
167MP0005381_digestive/alimentary_phenotyp0.59865358
168MP0004085_abnormal_heartbeat0.58776010
169MP0004130_abnormal_muscle_cell0.57295680
170MP0000477_abnormal_intestine_morphology0.57128851
171MP0000470_abnormal_stomach_morphology0.56814128
172MP0005666_abnormal_adipose_tissue0.55819941
173MP0000490_abnormal_crypts_of0.54583463
174MP0005330_cardiomyopathy0.54498271
175MP0003698_abnormal_male_reproductive0.54179136
176MP0000750_abnormal_muscle_regeneration0.54042695
177MP0001845_abnormal_inflammatory_respons0.54041816
178MP0010329_abnormal_lipoprotein_level0.53305032
179MP0004147_increased_porphyrin_level0.52620788
180MP0003890_abnormal_embryonic-extraembry0.52209495
181MP0000609_abnormal_liver_physiology0.52018268
182MP0003868_abnormal_feces_composition0.51663731
183MP0001664_abnormal_digestion0.50475465
184MP0004233_abnormal_muscle_weight0.49551977
185MP0003137_abnormal_impulse_conducting0.47227691
186MP0004782_abnormal_surfactant_physiolog0.47084207
187MP0003075_altered_response_to0.47060838
188MP0006072_abnormal_retinal_apoptosis0.45222578

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)9.46116213
2Morphological abnormality of the inner ear (HP:0011390)6.52459101
3Vacuolated lymphocytes (HP:0001922)5.45237446
4Facial shape deformation (HP:0011334)4.46918797
5Potter facies (HP:0002009)4.46918797
6Abnormality of the intrinsic pathway (HP:0010989)4.21142977
7Hyperglycinuria (HP:0003108)4.04570317
8Aortic aneurysm (HP:0004942)3.84802437
9Male infertility (HP:0003251)3.83559458
10Subcapsular cataract (HP:0000523)3.83194142
11Hand muscle atrophy (HP:0009130)3.80103387
12Pancreatic cysts (HP:0001737)3.77551177
13Hypomagnesemia (HP:0002917)3.71069299
14Pancreatic fibrosis (HP:0100732)3.47970580
15Abnormality of the labia minora (HP:0012880)3.42909622
16Dysostosis multiplex (HP:0000943)3.33627081
17Abnormality of glycine metabolism (HP:0010895)3.25590814
18Abnormality of serine family amino acid metabolism (HP:0010894)3.25590814
19Widely patent fontanelles and sutures (HP:0004492)3.22609825
20Colon cancer (HP:0003003)3.19977879
21Hypoplasia of the pons (HP:0012110)3.17263278
22True hermaphroditism (HP:0010459)3.13271759
23Molar tooth sign on MRI (HP:0002419)3.12726355
24Abnormality of midbrain morphology (HP:0002418)3.12726355
25Abnormality of magnesium homeostasis (HP:0004921)3.11231356
26Facial diplegia (HP:0001349)3.08281799
27Distal upper limb amyotrophy (HP:0007149)3.01172656
28Upper limb amyotrophy (HP:0009129)3.01172656
29Mucopolysacchariduria (HP:0008155)3.01080651
30Urinary glycosaminoglycan excretion (HP:0003541)3.01080651
31Hydroxyprolinuria (HP:0003080)2.95230104
32Abnormality of proline metabolism (HP:0010907)2.95230104
33Rectal prolapse (HP:0002035)2.92467623
34Congenital stationary night blindness (HP:0007642)2.91815232
35Abnormality of secondary sexual hair (HP:0009888)2.89502569
36Abnormality of the axillary hair (HP:0100134)2.89502569
37Achilles tendon contracture (HP:0001771)2.88587505
38Nephronophthisis (HP:0000090)2.87931540
39Birth length less than 3rd percentile (HP:0003561)2.81732795
40Abnormality of the pons (HP:0007361)2.80396166
41Abolished electroretinogram (ERG) (HP:0000550)2.78627159
42Gaze-evoked nystagmus (HP:0000640)2.78586540
43Progressive cerebellar ataxia (HP:0002073)2.75245289
44Abnormality of the Achilles tendon (HP:0005109)2.67474322
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65996706
46Abnormality of polysaccharide metabolism (HP:0011012)2.65996706
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65996706
48Pendular nystagmus (HP:0012043)2.65294740
49Genetic anticipation (HP:0003743)2.61417104
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.53691563
51Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.53691563
52Intention tremor (HP:0002080)2.53146097
53Sensorimotor neuropathy (HP:0007141)2.53136508
54Inability to walk (HP:0002540)2.52742344
55Myopathic facies (HP:0002058)2.52666375
56Aplasia involving bones of the extremities (HP:0009825)2.52496185
57Aplasia involving bones of the upper limbs (HP:0009823)2.52496185
58Aplasia of the phalanges of the hand (HP:0009802)2.52496185
59Bilateral microphthalmos (HP:0007633)2.50338180
60Progressive inability to walk (HP:0002505)2.50046205
61Hypoplasia of the uterus (HP:0000013)2.49435997
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48983736
63Abnormality of alanine metabolism (HP:0010916)2.48983736
64Hyperalaninemia (HP:0003348)2.48983736
65Cone-rod dystrophy (HP:0000548)2.48111438
66Abnormality of the renal medulla (HP:0100957)2.48100059
67Aortic dissection (HP:0002647)2.47978991
68Abnormality of the renal cortex (HP:0011035)2.43972148
69Protruding tongue (HP:0010808)2.43456765
70Sparse lateral eyebrow (HP:0005338)2.43161289
71Hypoplastic nipples (HP:0002557)2.42481138
72Hyperventilation (HP:0002883)2.42402858
73Attenuation of retinal blood vessels (HP:0007843)2.42123413
74Intellectual disability, moderate (HP:0002342)2.40740594
75Anosmia (HP:0000458)2.40423438
76Polar cataract (HP:0010696)2.38146715
77Chronic hepatic failure (HP:0100626)2.38007521
78Back pain (HP:0003418)2.36304352
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.35857396
80Medial flaring of the eyebrow (HP:0010747)2.35452593
81Shawl scrotum (HP:0000049)2.34272731
82Methylmalonic acidemia (HP:0002912)2.32260971
83Cystic liver disease (HP:0006706)2.29851423
84Thrombocytosis (HP:0001894)2.27172383
85Abnormal foot bone ossification (HP:0010675)2.27109060
86Aplastic anemia (HP:0001915)2.26984694
87Right ventricular cardiomyopathy (HP:0011663)2.25593285
88Retinal atrophy (HP:0001105)2.25120739
89Optic nerve hypoplasia (HP:0000609)2.23591290
90Congenital, generalized hypertrichosis (HP:0004540)2.23050810
91Type II lissencephaly (HP:0007260)2.23039166
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.23012223
93Coxa valga (HP:0002673)2.22435550
94Aplasia of the musculature (HP:0100854)2.21901145
95Abnormality of the ileum (HP:0001549)2.21330303
96Hyporeflexia of lower limbs (HP:0002600)2.20354183
97Meckel diverticulum (HP:0002245)2.19700818
98Chromsome breakage (HP:0040012)2.16000257
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14071703
100Beaking of vertebral bodies (HP:0004568)2.13544843
101Abnormality of the musculature of the hand (HP:0001421)2.13318367
102Stomach cancer (HP:0012126)2.13201660
103Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12472142
104Broad-based gait (HP:0002136)2.12077928
105Methylmalonic aciduria (HP:0012120)2.10888331
106Status epilepticus (HP:0002133)2.09914592
107Sclerocornea (HP:0000647)2.09306575
108Abnormality of the 2nd finger (HP:0004100)2.07435913
109Septo-optic dysplasia (HP:0100842)2.06157977
110Bile duct proliferation (HP:0001408)2.04848523
111Abnormal biliary tract physiology (HP:0012439)2.04848523
112Abnormality of chromosome stability (HP:0003220)2.04842836
113Hypoplasia of the ulna (HP:0003022)2.04455785
114Barrel-shaped chest (HP:0001552)2.04233843
115Hyperglycinemia (HP:0002154)2.02911437
116Aneurysm (HP:0002617)2.02265923
117Large for gestational age (HP:0001520)2.01417753
118Biliary tract neoplasm (HP:0100574)1.99436284
119Wide cranial sutures (HP:0010537)1.98609093
120Anencephaly (HP:0002323)1.98143974
121Acute necrotizing encephalopathy (HP:0006965)1.96936519
122Increased CSF lactate (HP:0002490)1.95931211
123Febrile seizures (HP:0002373)1.95664113
124Genital tract atresia (HP:0001827)1.92951576
125Dialeptic seizures (HP:0011146)1.90558270
126Lipid accumulation in hepatocytes (HP:0006561)1.90183276
127Pili torti (HP:0003777)1.90135755
128Tubular atrophy (HP:0000092)1.90054428
129Aplasia/Hypoplasia of the tibia (HP:0005772)1.88981247
130Agitation (HP:0000713)1.88834500
131Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.87433974
132Neoplasm of the adrenal cortex (HP:0100641)1.86558033
133Vaginal atresia (HP:0000148)1.86523832
134Mitochondrial inheritance (HP:0001427)1.86260836
135Acute encephalopathy (HP:0006846)1.86118097
136Lissencephaly (HP:0001339)1.85997612
137Abnormality of the common coagulation pathway (HP:0010990)1.84882933
138Intestinal atresia (HP:0011100)1.84775766
139Gait imbalance (HP:0002141)1.84128617
140Abnormality of serum amino acid levels (HP:0003112)1.83976861
141Furrowed tongue (HP:0000221)1.83963984
142Decreased central vision (HP:0007663)1.83817218
143Stroke (HP:0001297)1.83268542
144Polydipsia (HP:0001959)1.83005848
145Abnormal drinking behavior (HP:0030082)1.83005848
146Increased hepatocellular lipid droplets (HP:0006565)1.82817771
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.82250449
148Hypoplasia of the fovea (HP:0007750)1.82250449
149Sloping forehead (HP:0000340)1.81796556
150Abnormal tarsal ossification (HP:0008369)1.81385185
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.81152630
152Failure to thrive in infancy (HP:0001531)1.80754663
153Ankle clonus (HP:0011448)1.80627697
154Hematochezia (HP:0002573)1.80250230
155Progressive macrocephaly (HP:0004481)1.79710840
156Patellar aplasia (HP:0006443)1.79538059
157Testicular atrophy (HP:0000029)1.79397165
158Congenital primary aphakia (HP:0007707)1.78801852
159Clubbing of toes (HP:0100760)1.78642281
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77644041
161Ectopic kidney (HP:0000086)1.76828484
162Abnormality of transition element cation homeostasis (HP:0011030)1.76759812
163Infertility (HP:0000789)1.76175198
164Reduced antithrombin III activity (HP:0001976)1.76114235
165Cortical dysplasia (HP:0002539)1.74841575
166Abnormal rod and cone electroretinograms (HP:0008323)1.74453973
167Abnormality of homocysteine metabolism (HP:0010919)1.74423736
168Homocystinuria (HP:0002156)1.74423736
169Congenital hepatic fibrosis (HP:0002612)1.73569611
170Fair hair (HP:0002286)1.72978039
171Clumsiness (HP:0002312)1.72265298
172Dandy-Walker malformation (HP:0001305)1.71864657
173Ketosis (HP:0001946)1.71817089
174Bony spicule pigmentary retinopathy (HP:0007737)1.71602725
175Hyperinsulinemic hypoglycemia (HP:0000825)1.70079472
176Progressive muscle weakness (HP:0003323)1.69873224
177Thoracolumbar scoliosis (HP:0002944)1.68537031
178Type I transferrin isoform profile (HP:0003642)1.68476762
179Preaxial hand polydactyly (HP:0001177)1.68462470
180Male pseudohermaphroditism (HP:0000037)1.68259283
181Volvulus (HP:0002580)1.67605652
182Abnormality of the preputium (HP:0100587)1.67379137
183Stridor (HP:0010307)1.66902926
184Buphthalmos (HP:0000557)1.65900244
185Centrally nucleated skeletal muscle fibers (HP:0003687)1.65437370
186Ulnar deviation of the wrist (HP:0003049)1.65093961
187Abnormality of the corticospinal tract (HP:0002492)1.64003736
188Abnormal urine output (HP:0012590)1.63527931
189Abdominal distention (HP:0003270)1.62007526
190Abnormal hair laboratory examination (HP:0003328)1.61326125
191Exocrine pancreatic insufficiency (HP:0001738)1.59958650
192Short hallux (HP:0010109)1.59488898
193Infantile muscular hypotonia (HP:0008947)1.58940812
194Thoracic kyphosis (HP:0002942)1.58332500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT37.08988072
2FRK5.29218843
3ERN14.85942413
4MST44.35250892
5TAOK34.24691354
6LATS13.54083150
7EEF2K3.39722282
8ZAK3.17209290
9BCKDK2.96216193
10SIK12.74555120
11MKNK22.66963345
12SCYL22.66148340
13WNK32.65871012
14BMPR1B2.55199449
15TNIK2.48775000
16ACVR1B2.47030768
17ADRBK22.32046622
18MAP4K22.24667837
19PDK22.02528305
20MYLK1.98508483
21CDC71.94836284
22MAP3K21.93257089
23VRK21.85607586
24MAPKAPK31.84787897
25MKNK11.77510224
26OXSR11.74726987
27CASK1.72625226
28EPHA21.64624859
29TRIM281.62549396
30PLK31.59388853
31LMTK21.58032242
32TAF11.50971343
33BUB11.49593547
34TLK11.48336700
35PINK11.43958020
36VRK11.42923808
37TRIB31.42637328
38DYRK21.40284102
39LRRK21.38748622
40RPS6KB21.36552020
41TSSK61.27738547
42NUAK11.26603344
43PTK61.24647476
44TTN1.22897062
45TTK1.19712645
46MAPK131.18267950
47TESK21.16761465
48CSNK1G11.15397098
49JAK31.12527241
50SRPK11.10904981
51NLK1.09501038
52PDK41.06890146
53PDK31.06890146
54CDK191.04407514
55PLK41.03527581
56TESK11.01552965
57TXK0.98431864
58STK390.97355712
59CSNK1G20.96444299
60STK100.96181913
61PRKCG0.93415105
62PLK10.91483031
63CSNK1G30.90738193
64CHEK20.88002114
65PNCK0.87378809
66STK30.86279660
67CSF1R0.85007178
68PIK3CG0.83115532
69ICK0.82951975
70TNK20.79484117
71PAK30.79415291
72PDGFRA0.79075026
73PKN20.78926987
74CSNK1A1L0.77736648
75PLK20.76819480
76NEK20.76464938
77TIE10.76138613
78NTRK30.74567441
79ATR0.74552891
80PRKCE0.74412409
81DMPK0.74208197
82PAK20.71374166
83MST1R0.69968628
84PIK3CA0.69564103
85MET0.69377652
86TGFBR10.68467897
87NEK60.67707804
88FER0.66751975
89TEC0.66597473
90JAK20.64704809
91CAMK1D0.63735436
92RPS6KA20.63633799
93WEE10.63542305
94INSRR0.62796225
95WNK40.61633901
96NTRK10.60646756
97CAMKK20.59658965
98PRKCI0.59103215
99ATM0.58719585
100STK160.58220683
101KSR20.57973602
102ROCK20.57362247
103MAP2K20.55060610
104MAP3K30.52587640
105STK110.52378639
106BCR0.52060313
107RPS6KA50.50958933
108PDK10.50592802
109CAMK10.50321174
110JAK10.49020777
111CSNK1D0.48384673
112NEK10.47883838
113CDK30.47016909
114FGFR20.46095165
115LATS20.45606803
116PTK2B0.45581039
117MAPKAPK50.45508122
118DYRK30.45494070
119WNK10.45148107
120ROCK10.44865717
121STK38L0.44823286
122MTOR0.44369860
123PDPK10.43813625
124ALK0.42033095
125EIF2AK20.41835255
126CSNK1A10.41279284
127CAMK2A0.41020483
128PBK0.40515672
129TRPM70.40363624
130EIF2AK30.40154359
131DYRK1A0.38891827
132STK380.37928405
133CSNK1E0.36794049
134EPHB10.36485078
135DDR20.36324401
136RET0.35297052
137PASK0.34902152
138PKN10.34385734
139MAP2K70.33920703
140BTK0.33760761
141GRK10.33653328
142NME10.33352848
143DAPK10.33309835
144MAP3K80.31721673
145EPHA40.31455935
146PRKACA0.31031805
147PTK20.30425967
148PRKCQ0.30210378
149CSNK2A10.29370905
150PRKDC0.28963533
151DAPK20.28906229
152SGK20.28252446
153MAP3K40.28154434
154MAP2K30.28093682
155TAOK10.27771135
156PIM10.27701549
157TYK20.27677370
158MAP3K70.27442745
159PHKG20.27066087
160PHKG10.27066087
161RPS6KB10.26710212
162BMX0.26585834
163FYN0.24829357
164RIPK10.23950217
165CAMK1G0.23017428
166PRKAA10.22579482
167DAPK30.22127052
168ADRBK10.21014934
169EGFR0.18188712
170PRKD30.16497040
171PRKD10.15634431
172BRSK20.13829724
173CAMKK10.13771469
174INSR0.13643050
175RPS6KL10.13492006
176RPS6KC10.13492006
177MELK0.13173428
178PDGFRB0.13031967

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.85946167
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.60945854
3Sulfur metabolism_Homo sapiens_hsa009203.65985464
4Protein export_Homo sapiens_hsa030603.21256489
5RNA polymerase_Homo sapiens_hsa030202.89188062
6Homologous recombination_Homo sapiens_hsa034402.72712686
7N-Glycan biosynthesis_Homo sapiens_hsa005102.63460082
8Selenocompound metabolism_Homo sapiens_hsa004502.57436805
9Phototransduction_Homo sapiens_hsa047442.55522751
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.48229179
11Vibrio cholerae infection_Homo sapiens_hsa051102.21849479
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18553461
13Non-homologous end-joining_Homo sapiens_hsa034502.15660025
14Other glycan degradation_Homo sapiens_hsa005112.15039287
15One carbon pool by folate_Homo sapiens_hsa006702.09156175
16Fanconi anemia pathway_Homo sapiens_hsa034602.04811391
17Nicotine addiction_Homo sapiens_hsa050332.04530367
18Basal transcription factors_Homo sapiens_hsa030222.03007812
19Linoleic acid metabolism_Homo sapiens_hsa005912.02990173
20Mismatch repair_Homo sapiens_hsa034301.96678373
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94634412
22Oxidative phosphorylation_Homo sapiens_hsa001901.93143137
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87779754
24Prostate cancer_Homo sapiens_hsa052151.82257669
25RNA degradation_Homo sapiens_hsa030181.79897539
26Butanoate metabolism_Homo sapiens_hsa006501.76901760
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72099054
28Proteasome_Homo sapiens_hsa030501.66014700
29Renin-angiotensin system_Homo sapiens_hsa046141.65932015
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64858941
31Arginine biosynthesis_Homo sapiens_hsa002201.62933101
32Propanoate metabolism_Homo sapiens_hsa006401.60653698
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60120729
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58327028
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57866183
36Ether lipid metabolism_Homo sapiens_hsa005651.57629873
37Collecting duct acid secretion_Homo sapiens_hsa049661.53918401
38Tryptophan metabolism_Homo sapiens_hsa003801.51243731
39Parkinsons disease_Homo sapiens_hsa050121.51012807
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.48969354
41DNA replication_Homo sapiens_hsa030301.48101710
42Endometrial cancer_Homo sapiens_hsa052131.45570762
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42146952
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40318086
45Caffeine metabolism_Homo sapiens_hsa002321.31047515
46Fructose and mannose metabolism_Homo sapiens_hsa000511.29062364
47Taste transduction_Homo sapiens_hsa047421.26258624
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22753187
49Bladder cancer_Homo sapiens_hsa052191.21388395
50Tight junction_Homo sapiens_hsa045301.21205380
51RNA transport_Homo sapiens_hsa030131.20918489
52Purine metabolism_Homo sapiens_hsa002301.18270454
53Huntingtons disease_Homo sapiens_hsa050161.17776419
54Amoebiasis_Homo sapiens_hsa051461.16024794
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15934016
56Thyroid hormone synthesis_Homo sapiens_hsa049181.15684500
57Fatty acid degradation_Homo sapiens_hsa000711.14980953
58ABC transporters_Homo sapiens_hsa020101.10971241
59Olfactory transduction_Homo sapiens_hsa047401.09127289
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09080343
61Pyrimidine metabolism_Homo sapiens_hsa002401.08814157
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08170520
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.06886734
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05717382
65Small cell lung cancer_Homo sapiens_hsa052221.03969444
66Nucleotide excision repair_Homo sapiens_hsa034201.03837899
67Focal adhesion_Homo sapiens_hsa045101.00916652
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00207084
69Morphine addiction_Homo sapiens_hsa050321.00138178
70Spliceosome_Homo sapiens_hsa030400.99960916
71Base excision repair_Homo sapiens_hsa034100.98142469
72Synaptic vesicle cycle_Homo sapiens_hsa047210.96540342
73ECM-receptor interaction_Homo sapiens_hsa045120.93707603
74Alzheimers disease_Homo sapiens_hsa050100.91710220
75Retinol metabolism_Homo sapiens_hsa008300.91433261
76ErbB signaling pathway_Homo sapiens_hsa040120.91372721
77Hepatitis C_Homo sapiens_hsa051600.91034220
78Lysosome_Homo sapiens_hsa041420.90003169
79mTOR signaling pathway_Homo sapiens_hsa041500.89891501
80Serotonergic synapse_Homo sapiens_hsa047260.88919147
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88758716
82Inositol phosphate metabolism_Homo sapiens_hsa005620.88432423
83Non-small cell lung cancer_Homo sapiens_hsa052230.86717837
84Arginine and proline metabolism_Homo sapiens_hsa003300.85807535
85Glutamatergic synapse_Homo sapiens_hsa047240.85802585
86Protein digestion and absorption_Homo sapiens_hsa049740.85782239
87Vitamin B6 metabolism_Homo sapiens_hsa007500.84057715
88GABAergic synapse_Homo sapiens_hsa047270.82510595
89Peroxisome_Homo sapiens_hsa041460.81847011
90Glioma_Homo sapiens_hsa052140.80907494
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80569907
92Pyruvate metabolism_Homo sapiens_hsa006200.78242629
93Vitamin digestion and absorption_Homo sapiens_hsa049770.78121033
94Cardiac muscle contraction_Homo sapiens_hsa042600.78033219
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.77998490
96Insulin secretion_Homo sapiens_hsa049110.77003621
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76427426
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75884225
99Arachidonic acid metabolism_Homo sapiens_hsa005900.75318040
100Adherens junction_Homo sapiens_hsa045200.75316744
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.74308323
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74058427
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72912183
104Chemical carcinogenesis_Homo sapiens_hsa052040.72837557
105Sulfur relay system_Homo sapiens_hsa041220.71583528
106Insulin resistance_Homo sapiens_hsa049310.70717439
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70328322
108Steroid biosynthesis_Homo sapiens_hsa001000.69962212
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.68953034
110Circadian entrainment_Homo sapiens_hsa047130.67136129
111Metabolic pathways_Homo sapiens_hsa011000.66627543
112Fatty acid biosynthesis_Homo sapiens_hsa000610.65590346
113Nitrogen metabolism_Homo sapiens_hsa009100.65435844
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65412527
115AMPK signaling pathway_Homo sapiens_hsa041520.64397789
116Pancreatic cancer_Homo sapiens_hsa052120.63821343
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63018061
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62760132
119Cell cycle_Homo sapiens_hsa041100.62053139
120Ribosome_Homo sapiens_hsa030100.61792935
121Histidine metabolism_Homo sapiens_hsa003400.61399818
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60197201
123Choline metabolism in cancer_Homo sapiens_hsa052310.60054518
124Estrogen signaling pathway_Homo sapiens_hsa049150.59760617
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.57883652
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57595861
127Fatty acid metabolism_Homo sapiens_hsa012120.55851552
128Renin secretion_Homo sapiens_hsa049240.54323735
129Glycerolipid metabolism_Homo sapiens_hsa005610.54111351
130beta-Alanine metabolism_Homo sapiens_hsa004100.53633955
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53236065
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52942910
133Melanoma_Homo sapiens_hsa052180.52935491
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52923375
135Gap junction_Homo sapiens_hsa045400.50095777
136PPAR signaling pathway_Homo sapiens_hsa033200.49958854
137Regulation of autophagy_Homo sapiens_hsa041400.49743171
138mRNA surveillance pathway_Homo sapiens_hsa030150.48558433
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48173111
140Circadian rhythm_Homo sapiens_hsa047100.47699502
141Folate biosynthesis_Homo sapiens_hsa007900.47683732
142Calcium signaling pathway_Homo sapiens_hsa040200.47108449
143Hippo signaling pathway_Homo sapiens_hsa043900.46693467
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.46598226
145Ovarian steroidogenesis_Homo sapiens_hsa049130.46005318
146Oocyte meiosis_Homo sapiens_hsa041140.45915289
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45040130
148Pathways in cancer_Homo sapiens_hsa052000.42420401
149Endocytosis_Homo sapiens_hsa041440.42110657
150Chronic myeloid leukemia_Homo sapiens_hsa052200.41970169
151Long-term depression_Homo sapiens_hsa047300.41861333
152Fatty acid elongation_Homo sapiens_hsa000620.41315808
153TGF-beta signaling pathway_Homo sapiens_hsa043500.41081092
154Prion diseases_Homo sapiens_hsa050200.40946892
155Salivary secretion_Homo sapiens_hsa049700.39756334
156Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36118774
157Gastric acid secretion_Homo sapiens_hsa049710.35741633
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35677778
159Acute myeloid leukemia_Homo sapiens_hsa052210.34822868
160Fat digestion and absorption_Homo sapiens_hsa049750.34680624
161Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33894441
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33485987
163Antigen processing and presentation_Homo sapiens_hsa046120.32341455
164Proteoglycans in cancer_Homo sapiens_hsa052050.31042354
165Influenza A_Homo sapiens_hsa051640.30096326
166PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29903454
167Biosynthesis of amino acids_Homo sapiens_hsa012300.29534782
168Prolactin signaling pathway_Homo sapiens_hsa049170.29119929
169FoxO signaling pathway_Homo sapiens_hsa040680.28617095
170Cysteine and methionine metabolism_Homo sapiens_hsa002700.28569238
171Lysine degradation_Homo sapiens_hsa003100.27869852
172Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27753526
173Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27496528
174Phospholipase D signaling pathway_Homo sapiens_hsa040720.27395298
175Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27150405
176Long-term potentiation_Homo sapiens_hsa047200.26903742
177Starch and sucrose metabolism_Homo sapiens_hsa005000.25832479
178Carbon metabolism_Homo sapiens_hsa012000.24467895

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