GLCCI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1V(D)J recombination (GO:0033151)7.33051017
2positive regulation of gamma-delta T cell activation (GO:0046645)5.61703241
3positive T cell selection (GO:0043368)5.48650267
4cellular response to nitric oxide (GO:0071732)5.32566515
5RNA destabilization (GO:0050779)5.11443910
6retinal cone cell development (GO:0046549)4.87195066
7activated T cell proliferation (GO:0050798)4.81712277
8regulation of timing of cell differentiation (GO:0048505)4.77068592
9regulation of gamma-delta T cell differentiation (GO:0045586)4.74975887
10response to nitric oxide (GO:0071731)4.74795675
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.70801185
12negative regulation of cell killing (GO:0031342)4.70801185
13T cell selection (GO:0045058)4.63181565
14regulation of gamma-delta T cell activation (GO:0046643)4.59045593
15regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.55517292
16negative regulation of thymocyte apoptotic process (GO:0070244)4.54737570
17negative T cell selection (GO:0043383)4.53110770
18synapsis (GO:0007129)4.47762566
19male meiosis I (GO:0007141)4.29239492
20gonadal mesoderm development (GO:0007506)4.27659947
21regulation of development, heterochronic (GO:0040034)4.26678011
22presynaptic membrane assembly (GO:0097105)4.23570893
23forebrain morphogenesis (GO:0048853)4.19932541
24mRNA modification (GO:0016556)4.14124081
25cornea development in camera-type eye (GO:0061303)4.09986989
26rhodopsin mediated signaling pathway (GO:0016056)4.09535801
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.02878792
28regulation of rhodopsin mediated signaling pathway (GO:0022400)3.97514107
29mechanosensory behavior (GO:0007638)3.93750975
30limb bud formation (GO:0060174)3.70969030
31lens morphogenesis in camera-type eye (GO:0002089)3.70306691
32cellular response to reactive nitrogen species (GO:1902170)3.68816957
33chromosome organization involved in meiosis (GO:0070192)3.66846691
34presynaptic membrane organization (GO:0097090)3.64057123
35histone H3-K4 trimethylation (GO:0080182)3.52197995
36meiosis I (GO:0007127)3.51611047
37hindbrain development (GO:0030902)3.46299808
38modulation by virus of host process (GO:0019054)3.40921462
39positive thymic T cell selection (GO:0045059)3.40602929
40pancreas development (GO:0031016)3.40295129
41lens fiber cell differentiation (GO:0070306)3.40071594
42cerebellar granule cell differentiation (GO:0021707)3.38461927
43somite development (GO:0061053)3.37804426
44eye photoreceptor cell differentiation (GO:0001754)3.37280385
45photoreceptor cell differentiation (GO:0046530)3.37280385
46otic vesicle formation (GO:0030916)3.34729274
47autophagic vacuole fusion (GO:0000046)3.34457752
48stress granule assembly (GO:0034063)3.34252032
49monoubiquitinated protein deubiquitination (GO:0035520)3.32839227
50B cell receptor signaling pathway (GO:0050853)3.32625591
51DNA demethylation (GO:0080111)3.30092348
52axoneme assembly (GO:0035082)3.28893042
53regulation of meiosis I (GO:0060631)3.25092311
54inner ear receptor stereocilium organization (GO:0060122)3.23729865
55somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.21566196
56somatic cell DNA recombination (GO:0016444)3.21566196
57neural tube formation (GO:0001841)3.15202056
58negative thymic T cell selection (GO:0045060)3.13437548
59mitotic sister chromatid cohesion (GO:0007064)3.12021060
60epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.11927773
61centriole replication (GO:0007099)3.09771168
62neuron cell-cell adhesion (GO:0007158)3.07698629
63photoreceptor cell development (GO:0042461)3.06936211
64synaptonemal complex assembly (GO:0007130)3.01794196
65photoreceptor cell maintenance (GO:0045494)2.99221588
66histone H3-K9 demethylation (GO:0033169)2.98895765
67centriole assembly (GO:0098534)2.98816784
68T cell differentiation (GO:0030217)2.97701135
69positive regulation of granulocyte differentiation (GO:0030854)2.96142765
70somatic diversification of immune receptors (GO:0002200)2.95867830
71astrocyte differentiation (GO:0048708)2.94903792
72positive regulation of interleukin-2 production (GO:0032743)2.94736843
73histone H3-K4 methylation (GO:0051568)2.93641915
74cochlea development (GO:0090102)2.92860450
75negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.92418801
76negative regulation of translation, ncRNA-mediated (GO:0040033)2.92418801
77regulation of translation, ncRNA-mediated (GO:0045974)2.92418801
78peptidyl-lysine trimethylation (GO:0018023)2.92414377
79organ formation (GO:0048645)2.92367908
80microtubule depolymerization (GO:0007019)2.91136018
81eye photoreceptor cell development (GO:0042462)2.90774664
82nonmotile primary cilium assembly (GO:0035058)2.90476354
83postsynaptic membrane organization (GO:0001941)2.88719534
84T cell receptor signaling pathway (GO:0050852)2.88466303
85antigen receptor-mediated signaling pathway (GO:0050851)2.87378771
86alpha-beta T cell differentiation (GO:0046632)2.86698735
87synaptonemal complex organization (GO:0070193)2.85783677
88negative regulation of T cell mediated immunity (GO:0002710)2.85532781
89reciprocal DNA recombination (GO:0035825)2.84085868
90reciprocal meiotic recombination (GO:0007131)2.84085868
91histone lysine demethylation (GO:0070076)2.83249729
92organelle membrane fusion (GO:0090174)2.82611642
93neuron fate commitment (GO:0048663)2.81624306
94histone H3-K9 methylation (GO:0051567)2.81087921
95forebrain neuron differentiation (GO:0021879)2.80555542
96interkinetic nuclear migration (GO:0022027)2.78646173
97genitalia morphogenesis (GO:0035112)2.78352955
98meiotic nuclear division (GO:0007126)2.75465258
99histone demethylation (GO:0016577)2.75461163
100regulation of interleukin-2 biosynthetic process (GO:0045076)2.74081887
101detection of light stimulus involved in visual perception (GO:0050908)2.73384060
102detection of light stimulus involved in sensory perception (GO:0050962)2.73384060
103positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73380149
104chromatin remodeling at centromere (GO:0031055)2.72786321
105phagocytosis, engulfment (GO:0006911)2.72503311
106embryonic camera-type eye morphogenesis (GO:0048596)2.71960743
107negative regulation of T cell apoptotic process (GO:0070233)2.70778909
108interferon-gamma production (GO:0032609)2.70652205
109histone monoubiquitination (GO:0010390)2.69987662
110positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.69527088
111regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.69527088
112hepatocyte apoptotic process (GO:0097284)2.69305004
113tongue development (GO:0043586)2.68875209
114CENP-A containing nucleosome assembly (GO:0034080)2.68707046
115B cell proliferation (GO:0042100)2.67667944
116ionotropic glutamate receptor signaling pathway (GO:0035235)2.66658305
117Sertoli cell development (GO:0060009)2.64041813
118gene silencing by RNA (GO:0031047)2.63717990
119positive regulation of cell fate commitment (GO:0010455)2.63426388
120negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.62916953
121DNA double-strand break processing (GO:0000729)2.62690456
122mast cell activation (GO:0045576)2.62128289
123positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.61973894
124spinal cord motor neuron differentiation (GO:0021522)2.61587698
125regulation of energy homeostasis (GO:2000505)2.61064263
126histone H3-K36 demethylation (GO:0070544)2.60937045
127thymic T cell selection (GO:0045061)2.59244034
128regulation of thymocyte apoptotic process (GO:0070243)2.58526508
129protein dealkylation (GO:0008214)2.58371757
130protein demethylation (GO:0006482)2.58371757
131modulation by symbiont of host cellular process (GO:0044068)2.58363970
132regulation of RNA export from nucleus (GO:0046831)2.57027105
133meiotic cell cycle process (GO:1903046)2.56951237
134alpha-beta T cell activation (GO:0046631)2.56702619
135telencephalon development (GO:0021537)2.56592880
136cytoplasmic mRNA processing body assembly (GO:0033962)2.56145763
137cilium morphogenesis (GO:0060271)2.53783082
138positive regulation of oligodendrocyte differentiation (GO:0048714)2.53081076
139positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52637078
140regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52637078
141neuron fate determination (GO:0048664)2.51764266
142histone lysine methylation (GO:0034968)2.51345931
143sympathetic nervous system development (GO:0048485)2.51147675
144regulation of platelet aggregation (GO:0090330)2.50995991
145histone exchange (GO:0043486)2.50736351
146pituitary gland development (GO:0021983)2.50207452
147regulation of B cell differentiation (GO:0045577)2.50119707
148ribosomal small subunit assembly (GO:0000028)2.49912951
149sister chromatid cohesion (GO:0007062)2.49554480
150histone H2A acetylation (GO:0043968)2.49264734
151snRNA transcription (GO:0009301)2.49023875
152T cell costimulation (GO:0031295)2.48971886
153cardiac ventricle formation (GO:0003211)2.48918251
154DNA methylation (GO:0006306)2.48092372
155DNA alkylation (GO:0006305)2.48092372
156regulation of histone H3-K9 methylation (GO:0051570)2.46979354
157histone H4-K16 acetylation (GO:0043984)2.46890753
158positive regulation of gluconeogenesis (GO:0045722)2.46694668
159piRNA metabolic process (GO:0034587)2.46616983
160microtubule polymerization or depolymerization (GO:0031109)2.44291726
161lymphocyte costimulation (GO:0031294)2.43887849
162positive regulation of calcium-mediated signaling (GO:0050850)2.42584622
163regulation of odontogenesis (GO:0042481)2.41266815
164positive regulation of B cell differentiation (GO:0045579)2.40904382
165CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.40650075
166mast cell activation involved in immune response (GO:0002279)2.40392252
167mast cell degranulation (GO:0043303)2.40392252
168positive regulation of histone H3-K4 methylation (GO:0051571)2.38716104
169regulation of NFAT protein import into nucleus (GO:0051532)2.38352459
170DNA dealkylation (GO:0035510)2.38085080
171oxidative demethylation (GO:0070989)2.37762321
172microtubule anchoring (GO:0034453)2.37664037
173meiotic cell cycle (GO:0051321)2.37507778
174limb development (GO:0060173)2.36261289
175regulation of chromatin silencing (GO:0031935)2.36230794
176positive regulation of alpha-beta T cell proliferation (GO:0046641)2.36039256
177histone H3-K9 modification (GO:0061647)2.34565395
178DNA methylation involved in gamete generation (GO:0043046)2.34365846
179regulation of histone methylation (GO:0031060)2.33222587
180male meiosis (GO:0007140)2.33073816
181T cell homeostasis (GO:0043029)2.32154060
182regulation of alpha-beta T cell proliferation (GO:0046640)2.32034206
183mucosal-associated lymphoid tissue development (GO:0048537)2.31172692
184Peyers patch development (GO:0048541)2.31172692
185positive regulation of guanylate cyclase activity (GO:0031284)2.30159087
186T cell lineage commitment (GO:0002360)2.27722389
187multicellular organism reproduction (GO:0032504)2.27470196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.08064398
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.05312814
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.13438260
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.41444353
5EZH2_22144423_ChIP-Seq_EOC_Human2.39975143
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37828918
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36137941
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29286602
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24286635
10RUNX_20019798_ChIP-Seq_JUKART_Human2.20573354
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18686862
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13005919
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12173829
14GBX2_23144817_ChIP-Seq_PC3_Human2.04563589
15IGF1R_20145208_ChIP-Seq_DFB_Human1.99267963
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91865137
17ZNF274_21170338_ChIP-Seq_K562_Hela1.84827683
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.78878621
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73522922
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72255837
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71977508
22TAF15_26573619_Chip-Seq_HEK293_Human1.70347616
23IRF1_19129219_ChIP-ChIP_H3396_Human1.68840105
24VDR_22108803_ChIP-Seq_LS180_Human1.63507849
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60647678
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.55621111
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.55279137
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54788775
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53693438
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52983795
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50144398
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47671444
33P300_19829295_ChIP-Seq_ESCs_Human1.46464897
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46031469
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45160451
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44021841
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44021841
38LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40920203
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40303786
40RNF2_27304074_Chip-Seq_NSC_Mouse1.38548166
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38223585
42EWS_26573619_Chip-Seq_HEK293_Human1.35425893
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.35195684
44CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34776314
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.34612259
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33243797
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.33116628
48CBP_20019798_ChIP-Seq_JUKART_Human1.32625174
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32625174
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32100332
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30638225
52MYC_18940864_ChIP-ChIP_HL60_Human1.30248631
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29513909
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29028785
55CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.27153894
56GATA3_27048872_Chip-Seq_THYMUS_Human1.27149900
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26581552
58* STAT3_23295773_ChIP-Seq_U87_Human1.26309457
59* RUNX2_22187159_ChIP-Seq_PCA_Human1.25057201
60FUS_26573619_Chip-Seq_HEK293_Human1.23952150
61* MYB_26560356_Chip-Seq_TH2_Human1.23300652
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.21686799
63BCAT_22108803_ChIP-Seq_LS180_Human1.20441018
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18601472
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.18402361
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18348598
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.18091436
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.17768419
69TCF4_23295773_ChIP-Seq_U87_Human1.16526782
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15824276
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15655706
72REST_21632747_ChIP-Seq_MESCs_Mouse1.15593589
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.14918976
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14696445
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.14496281
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13115825
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.12377161
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12276158
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12116551
80RXR_22108803_ChIP-Seq_LS180_Human1.12103022
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11131346
82SMAD4_21799915_ChIP-Seq_A2780_Human1.09646625
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08833752
84NMYC_18555785_Chip-Seq_ESCs_Mouse1.08827788
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07918794
86AHR_22903824_ChIP-Seq_MCF-7_Human1.07783430
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06764997
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.05241699
89ER_23166858_ChIP-Seq_MCF-7_Human1.04439980
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04217911
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03958101
92P53_22387025_ChIP-Seq_ESCs_Mouse1.03922923
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.03725350
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.03625641
95* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03610026
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03157058
97TBL1_22424771_ChIP-Seq_293T_Human1.02307587
98AR_25329375_ChIP-Seq_VCAP_Human1.01843938
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.01705227
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01682561
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01267075
102AR_21572438_ChIP-Seq_LNCaP_Human1.00119176
103STAT3_18555785_Chip-Seq_ESCs_Mouse0.99878906
104* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99783361
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99683928
106VDR_24787735_ChIP-Seq_THP-1_Human0.99515186
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98357012
108FOXM1_23109430_ChIP-Seq_U2OS_Human0.98112740
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.97972533
110* MYC_22102868_ChIP-Seq_BL_Human0.97857849
111TCF4_22108803_ChIP-Seq_LS180_Human0.97705684
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97226939
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97056180
114CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95334045
115SMRT_27268052_Chip-Seq_Bcells_Human0.94540789
116SCL_19346495_ChIP-Seq_HPC-7_Human0.94075663
117OCT4_18555785_Chip-Seq_ESCs_Mouse0.92733748
118KDM2B_26808549_Chip-Seq_REH_Human0.92150541
119TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.91768411
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91743506
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91542158
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91489640
123P300_18555785_Chip-Seq_ESCs_Mouse0.91187684
124KLF4_18555785_Chip-Seq_ESCs_Mouse0.89684839
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89640355
126SOX9_26525672_Chip-Seq_HEART_Mouse0.89595293
127ZFX_18555785_Chip-Seq_ESCs_Mouse0.89547635
128* TAL1_26923725_Chip-Seq_HPCs_Mouse0.88949227
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88920481
130BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88131507
131RNF2_27304074_Chip-Seq_ESCs_Mouse0.87605810
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87564918
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87504120
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87278607
135GF1_26923725_Chip-Seq_HPCs_Mouse0.87076819
136UTX_26944678_Chip-Seq_JUKART_Human0.87049171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.08767094
2MP0005409_darkened_coat_color3.51632419
3MP0008877_abnormal_DNA_methylation3.47854577
4MP0003763_abnormal_thymus_physiology3.02202036
5MP0001986_abnormal_taste_sensitivity2.89479615
6MP0001984_abnormal_olfaction2.78437506
7MP0005551_abnormal_eye_electrophysiolog2.63124121
8MP0005671_abnormal_response_to2.60602748
9MP0002132_abnormal_respiratory_system2.59085921
10MP0000703_abnormal_thymus_morphology2.22487505
11MP0002166_altered_tumor_susceptibility2.13227202
12MP0003890_abnormal_embryonic-extraembry1.99947324
13MP0005451_abnormal_body_composition1.96058208
14MP0006292_abnormal_olfactory_placode1.90633948
15MP0001800_abnormal_humoral_immune1.90129695
16MP0000015_abnormal_ear_pigmentation1.88869507
17MP0001790_abnormal_immune_system1.86181738
18MP0005387_immune_system_phenotype1.86181738
19MP0002928_abnormal_bile_duct1.83874865
20MP0006072_abnormal_retinal_apoptosis1.83632295
21MP0002006_tumorigenesis1.78387013
22MP0002398_abnormal_bone_marrow1.74459964
23MP0005253_abnormal_eye_physiology1.73986579
24MP0008057_abnormal_DNA_replication1.68067074
25MP0010094_abnormal_chromosome_stability1.58165903
26MP0008789_abnormal_olfactory_epithelium1.57652470
27MP0005646_abnormal_pituitary_gland1.57627458
28MP0003121_genomic_imprinting1.56215007
29MP0002095_abnormal_skin_pigmentation1.55772738
30MP0002009_preneoplasia1.54425059
31MP0002938_white_spotting1.46019568
32MP0001835_abnormal_antigen_presentation1.45600932
33MP0005499_abnormal_olfactory_system1.45111824
34MP0005394_taste/olfaction_phenotype1.45111824
35MP0002420_abnormal_adaptive_immunity1.43941839
36MP0000569_abnormal_digit_pigmentation1.43849917
37MP0005310_abnormal_salivary_gland1.42532440
38MP0001819_abnormal_immune_cell1.41601028
39MP0000716_abnormal_immune_system1.40448194
40MP0002736_abnormal_nociception_after1.40376246
41MP0002282_abnormal_trachea_morphology1.39607809
42MP0005410_abnormal_fertilization1.37576149
43MP0000685_abnormal_immune_system1.35957451
44MP0002751_abnormal_autonomic_nervous1.34012289
45MP0001849_ear_inflammation1.32804855
46MP0002452_abnormal_antigen_presenting1.32487994
47MP0002723_abnormal_immune_serum1.32469220
48MP0000049_abnormal_middle_ear1.31253362
49MP0002735_abnormal_chemical_nociception1.31054082
50MP0009379_abnormal_foot_pigmentation1.31001845
51MP0001286_abnormal_eye_development1.30722132
52MP0002405_respiratory_system_inflammati1.29726257
53MP0003136_yellow_coat_color1.29088866
54MP0001968_abnormal_touch/_nociception1.28843996
55MP0003122_maternal_imprinting1.27350569
56MP0002722_abnormal_immune_system1.26295052
57MP0001486_abnormal_startle_reflex1.25828514
58MP0008007_abnormal_cellular_replicative1.25245745
59MP0000689_abnormal_spleen_morphology1.24625738
60MP0004808_abnormal_hematopoietic_stem1.24129776
61MP0001145_abnormal_male_reproductive1.23543637
62MP0005389_reproductive_system_phenotype1.22219639
63MP0001188_hyperpigmentation1.21591168
64MP0000566_synostosis1.21491384
65MP0005423_abnormal_somatic_nervous1.21173828
66MP0003567_abnormal_fetal_cardiomyocyte1.20057071
67MP0008058_abnormal_DNA_repair1.19919882
68MP0001929_abnormal_gametogenesis1.17724171
69MP0003635_abnormal_synaptic_transmissio1.15408650
70MP0005000_abnormal_immune_tolerance1.14619538
71MP0003880_abnormal_central_pattern1.12013316
72MP0000427_abnormal_hair_cycle1.11683720
73MP0009333_abnormal_splenocyte_physiolog1.09875977
74MP0010155_abnormal_intestine_physiology1.09713372
75MP0003937_abnormal_limbs/digits/tail_de1.09675652
76MP0003935_abnormal_craniofacial_develop1.09406800
77MP0001529_abnormal_vocalization1.07658714
78MP0003283_abnormal_digestive_organ1.06960766
79MP0003755_abnormal_palate_morphology1.06727708
80MP0004742_abnormal_vestibular_system1.06698164
81MP0005195_abnormal_posterior_eye1.06004408
82MP0002102_abnormal_ear_morphology1.04006538
83MP0000428_abnormal_craniofacial_morphol1.03591068
84MP0002148_abnormal_hypersensitivity_rea1.02393602
85MP0001919_abnormal_reproductive_system1.02245978
86MP0006082_CNS_inflammation1.01432375
87MP0002249_abnormal_larynx_morphology1.01210429
88MP0005391_vision/eye_phenotype1.00487701
89MP0002429_abnormal_blood_cell1.00113584
90MP0010678_abnormal_skin_adnexa0.99989731
91MP0003938_abnormal_ear_development0.99881397
92MP0000465_gastrointestinal_hemorrhage0.98861409
93MP0001873_stomach_inflammation0.98541187
94MP0004947_skin_inflammation0.98305660
95MP0001502_abnormal_circadian_rhythm0.98220524
96MP0001879_abnormal_lymphatic_vessel0.98112340
97MP0005645_abnormal_hypothalamus_physiol0.97552606
98MP0003698_abnormal_male_reproductive0.97150220
99MP0002638_abnormal_pupillary_reflex0.96456737
100MP0002163_abnormal_gland_morphology0.95755314
101MP0009785_altered_susceptibility_to0.94248468
102MP0005174_abnormal_tail_pigmentation0.94105493
103MP0003879_abnormal_hair_cell0.93448703
104MP0010307_abnormal_tumor_latency0.92338992
105MP0009745_abnormal_behavioral_response0.92084259
106MP0009703_decreased_birth_body0.89910510
107MP0000026_abnormal_inner_ear0.89821524
108MP0003861_abnormal_nervous_system0.89393354
109MP0002734_abnormal_mechanical_nocicepti0.87595918
110MP0002210_abnormal_sex_determination0.87450358
111MP0002233_abnormal_nose_morphology0.87352280
112MP0003943_abnormal_hepatobiliary_system0.86475324
113MP0000647_abnormal_sebaceous_gland0.86399639
114MP0001905_abnormal_dopamine_level0.86061859
115MP0002067_abnormal_sensory_capabilities0.85679086
116MP0001119_abnormal_female_reproductive0.85623910
117MP0002822_catalepsy0.85006232
118MP0004859_abnormal_synaptic_plasticity0.84723620
119MP0002063_abnormal_learning/memory/cond0.83370252
120MP0009046_muscle_twitch0.83369269
121MP0000613_abnormal_salivary_gland0.82881797
122MP0000631_abnormal_neuroendocrine_gland0.82613277
123MP0004142_abnormal_muscle_tone0.82368730
124MP0003123_paternal_imprinting0.82199846
125MP0010386_abnormal_urinary_bladder0.81940735
126MP0002064_seizures0.79763916
127MP0008569_lethality_at_weaning0.79531448
128MP0009250_abnormal_appendicular_skeleto0.79514856
129MP0002876_abnormal_thyroid_physiology0.78382011
130MP0004885_abnormal_endolymph0.78029433
131MP0002184_abnormal_innervation0.77769499
132MP0002752_abnormal_somatic_nervous0.77508013
133MP0003077_abnormal_cell_cycle0.76272157
134MP0006054_spinal_hemorrhage0.74950236
135MP0002572_abnormal_emotion/affect_behav0.74576167
136MP0001485_abnormal_pinna_reflex0.74503070
137MP0002127_abnormal_cardiovascular_syste0.74373920
138MP0003866_abnormal_defecation0.73927228
139MP0000778_abnormal_nervous_system0.73786873
140MP0001293_anophthalmia0.73446930
141MP0001963_abnormal_hearing_physiology0.73443366
142MP0000955_abnormal_spinal_cord0.73408799
143MP0002116_abnormal_craniofacial_bone0.73119300
144MP0002152_abnormal_brain_morphology0.73042449
145MP0000920_abnormal_myelination0.73003333
146MP0005220_abnormal_exocrine_pancreas0.72571898
147MP0000653_abnormal_sex_gland0.69999416
148MP0002160_abnormal_reproductive_system0.69711441
149MP0001186_pigmentation_phenotype0.69557308
150MP0002653_abnormal_ependyma_morphology0.69166105
151MP0002933_joint_inflammation0.68386018
152MP0002019_abnormal_tumor_incidence0.67271688
153MP0000383_abnormal_hair_follicle0.67188969
154MP0002557_abnormal_social/conspecific_i0.65016263
155MP0002272_abnormal_nervous_system0.64762543
156MP0000490_abnormal_crypts_of0.63637538
157MP0001944_abnormal_pancreas_morphology0.62229989
158MP0002075_abnormal_coat/hair_pigmentati0.61535819
159MP0008995_early_reproductive_senescence0.60888389

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)7.23649187
2Abnormality of B cell number (HP:0010975)7.23649187
3Thyroiditis (HP:0100646)7.03978156
4Severe combined immunodeficiency (HP:0004430)6.20426220
5T lymphocytopenia (HP:0005403)6.18384755
6Abnormality of T cell number (HP:0011839)5.88118702
7Panhypogammaglobulinemia (HP:0003139)5.59592961
8Congenital stationary night blindness (HP:0007642)5.23377440
9Hypoplasia of the thymus (HP:0000778)5.11792900
10Combined immunodeficiency (HP:0005387)5.10671672
11Rhabdomyosarcoma (HP:0002859)4.32226108
12Eosinophilia (HP:0001880)4.30799370
13Recurrent viral infections (HP:0004429)4.26839399
14Hypoproteinemia (HP:0003075)3.95244671
15Abnormality of eosinophils (HP:0001879)3.71699422
16Neoplasm of striated muscle (HP:0009728)3.61426192
17Abnormality of the fingertips (HP:0001211)3.60318873
18Bony spicule pigmentary retinopathy (HP:0007737)3.44857161
19Hyperventilation (HP:0002883)3.40699357
20Agammaglobulinemia (HP:0004432)3.35676888
21Granulocytopenia (HP:0001913)3.31257886
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.19974254
23Abnormal rod and cone electroretinograms (HP:0008323)3.15178724
24Recurrent fungal infections (HP:0002841)2.86163106
25Abnormality of T cells (HP:0002843)2.83755574
26Volvulus (HP:0002580)2.82827338
27IgG deficiency (HP:0004315)2.82254910
28Abnormality of the phalanges of the 2nd finger (HP:0009541)2.80959770
29Facial hemangioma (HP:0000329)2.79275329
30Abnormality of the intervertebral disk (HP:0005108)2.74724646
31Recurrent sinusitis (HP:0011108)2.72857982
32Oligodactyly (HP:0012165)2.72050245
33Papillary thyroid carcinoma (HP:0002895)2.70212968
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.69562833
35Meningitis (HP:0001287)2.66956770
36Erythroderma (HP:0001019)2.63385803
37Intestinal atresia (HP:0011100)2.59014221
38Leukocytosis (HP:0001974)2.55405107
39Optic nerve hypoplasia (HP:0000609)2.53566544
40Hypoplasia of the fovea (HP:0007750)2.52591566
41Aplasia/Hypoplasia of the fovea (HP:0008060)2.52591566
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.47610707
43Abnormal hair whorl (HP:0010721)2.46966293
44Pigmentary retinal degeneration (HP:0001146)2.40473919
45Abnormality of the labia minora (HP:0012880)2.39598594
46Septo-optic dysplasia (HP:0100842)2.38152505
47Medulloblastoma (HP:0002885)2.36686919
48Focal motor seizures (HP:0011153)2.34666449
4911 pairs of ribs (HP:0000878)2.27695965
50Nephrogenic diabetes insipidus (HP:0009806)2.26628869
51Attenuation of retinal blood vessels (HP:0007843)2.23388396
52Medial flaring of the eyebrow (HP:0010747)2.23271569
53Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21345136
54Recurrent otitis media (HP:0000403)2.18035477
55Gait imbalance (HP:0002141)2.18025710
56Abnormality of the fovea (HP:0000493)2.15844892
57Congenital primary aphakia (HP:0007707)2.14723426
58Abnormality of chromosome stability (HP:0003220)2.14598632
59Sepsis (HP:0100806)2.10576028
60Nephronophthisis (HP:0000090)2.08608290
61Colon cancer (HP:0003003)2.07950244
62Abnormality of macular pigmentation (HP:0008002)2.07608562
63Aqueductal stenosis (HP:0002410)2.07505461
64Chronic otitis media (HP:0000389)2.06183156
65Verrucae (HP:0200043)2.05903052
66Papilloma (HP:0012740)2.05903052
67Pendular nystagmus (HP:0012043)2.03104120
68Bronchiectasis (HP:0002110)2.02459120
69Small epiphyses (HP:0010585)2.01206321
70Diastasis recti (HP:0001540)2.00133092
71Hepatoblastoma (HP:0002884)1.99411939
72Gonadotropin excess (HP:0000837)1.99199757
73Abnormality of chromosome segregation (HP:0002916)1.98348525
74Gonadal dysgenesis (HP:0000133)1.97482374
75Decreased central vision (HP:0007663)1.95675904
76Recurrent bronchitis (HP:0002837)1.95467748
77Optic nerve coloboma (HP:0000588)1.95408122
782-3 toe syndactyly (HP:0004691)1.92610791
79Pancreatic cysts (HP:0001737)1.92458437
80Type II diabetes mellitus (HP:0005978)1.92076940
81Dyschromatopsia (HP:0007641)1.91238024
82Absent speech (HP:0001344)1.91033125
83Nephroblastoma (Wilms tumor) (HP:0002667)1.89661415
84Neoplasm of the adrenal cortex (HP:0100641)1.89256595
85Poor coordination (HP:0002370)1.88670617
86Photophobia (HP:0000613)1.87403782
87Embryonal renal neoplasm (HP:0011794)1.87348976
88Oligodactyly (hands) (HP:0001180)1.87329142
89Chorioretinal atrophy (HP:0000533)1.86777049
90Abnormality of the renal medulla (HP:0100957)1.86759375
91Hypoplastic iliac wings (HP:0002866)1.86394756
92Abnormal respiratory motile cilium physiology (HP:0012261)1.84945441
93Chronic sinusitis (HP:0011109)1.83760642
94Thyroid carcinoma (HP:0002890)1.83166189
95Broad-based gait (HP:0002136)1.82807135
96Triphalangeal thumb (HP:0001199)1.82396231
97Megalencephaly (HP:0001355)1.81962681
98Lip pit (HP:0100267)1.81891682
99Ectopic kidney (HP:0000086)1.81694340
100Pancreatic fibrosis (HP:0100732)1.80096340
101Dynein arm defect of respiratory motile cilia (HP:0012255)1.79913709
102Absent/shortened dynein arms (HP:0200106)1.79913709
103Severe global developmental delay (HP:0011344)1.79650245
104Abnormal delayed hypersensitivity skin test (HP:0002963)1.79334313
105Deep philtrum (HP:0002002)1.78515021
106Abnormal sex determination (HP:0012244)1.77229605
107Sex reversal (HP:0012245)1.77229605
108Drooling (HP:0002307)1.76872448
109Growth hormone deficiency (HP:0000824)1.76006324
110Hamartoma (HP:0010566)1.75524462
111Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.74956546
112Gastrointestinal atresia (HP:0002589)1.72729981
113Abnormality of the duodenum (HP:0002246)1.72272246
114Retrobulbar optic neuritis (HP:0100654)1.72006271
115Optic neuritis (HP:0100653)1.72006271
116Excessive salivation (HP:0003781)1.71932451
117Recurrent cutaneous fungal infections (HP:0011370)1.71904870
118Chronic mucocutaneous candidiasis (HP:0002728)1.71904870
119Genital tract atresia (HP:0001827)1.71670378
120Acute lymphatic leukemia (HP:0006721)1.71031001
121Protruding tongue (HP:0010808)1.70886025
122Preaxial hand polydactyly (HP:0001177)1.70843837
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.70491821
124Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69333264
125Exotropia (HP:0000577)1.69098045
126Long eyelashes (HP:0000527)1.69039206
127Lymphopenia (HP:0001888)1.68884068
128Widely spaced teeth (HP:0000687)1.68778264
129Vaginal atresia (HP:0000148)1.68357191
130Degeneration of the lateral corticospinal tracts (HP:0002314)1.67971146
131Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67971146
132Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67912199
133True hermaphroditism (HP:0010459)1.67824099
134Esophageal atresia (HP:0002032)1.67687618
135Neoplasm of the oral cavity (HP:0100649)1.67214101
136Anophthalmia (HP:0000528)1.66859648
137Depressed nasal tip (HP:0000437)1.66510586
138Abnormality of the septum pellucidum (HP:0007375)1.66098437
139Fair hair (HP:0002286)1.65245777
140Bronchitis (HP:0012387)1.65243494
141Thyroid-stimulating hormone excess (HP:0002925)1.65082620
142Aplasia/Hypoplasia of the lens (HP:0008063)1.64085391
143Abnormal lung lobation (HP:0002101)1.63885994
144Abnormality of the phalanges of the 5th finger (HP:0004213)1.63595411
145Patellar aplasia (HP:0006443)1.62066244
146Abnormality of cells of the lymphoid lineage (HP:0012140)1.62038609
147Flattened epiphyses (HP:0003071)1.60866115
148Rhinitis (HP:0012384)1.59184443
149Chromsome breakage (HP:0040012)1.58977950
150Highly arched eyebrow (HP:0002553)1.58745516
151Hypoplastic labia majora (HP:0000059)1.58651667
152Wide intermamillary distance (HP:0006610)1.58454223
153Small hand (HP:0200055)1.58330545
154Renal hypoplasia (HP:0000089)1.57817821
155Cellulitis (HP:0100658)1.57592816
156Febrile seizures (HP:0002373)1.57387631
157Metaphyseal dysplasia (HP:0100255)1.57005180
158Retinitis pigmentosa (HP:0000510)1.56806296
159Abnormality of incisor morphology (HP:0011063)1.56254490
160Lymphoma (HP:0002665)1.56185926
161Abnormality of the pubic bones (HP:0003172)1.56176717
162Nephrotic syndrome (HP:0000100)1.56044718
163Abnormal respiratory epithelium morphology (HP:0012253)1.55942886
164Abnormal respiratory motile cilium morphology (HP:0005938)1.55942886
165Truncal obesity (HP:0001956)1.55551031
166Limb dystonia (HP:0002451)1.55219316
167Type 2 muscle fiber atrophy (HP:0003554)1.55174717
168Absent septum pellucidum (HP:0001331)1.54944767
169Abnormality of midbrain morphology (HP:0002418)1.54932365
170Molar tooth sign on MRI (HP:0002419)1.54932365
171Gastrointestinal stroma tumor (HP:0100723)1.52598315
172Encephalitis (HP:0002383)1.51332639
173Acute myeloid leukemia (HP:0004808)1.49549036
174Colitis (HP:0002583)1.48903136
175Sparse lateral eyebrow (HP:0005338)1.48471405
176Midline defect of the nose (HP:0004122)1.47849794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.32097743
2TXK3.94413546
3MAP3K102.97708931
4PNCK2.93113474
5WEE12.48874723
6PRPF4B2.46007461
7YES12.29875343
8BMPR22.07818962
9MARK12.02410383
10CDK91.96388969
11BRSK21.92175318
12FRK1.90943844
13ZAK1.84208443
14CDK121.74361201
15MAP4K11.72936515
16NUAK11.63493431
17WNK31.55566556
18CCNB11.53816099
19CLK11.47844707
20FGFR21.47786561
21GRK61.44532416
22EIF2AK31.44485835
23BMPR1B1.44285841
24CSNK1A1L1.43363874
25MAPK131.42221798
26PRKD21.38828202
27MELK1.37564923
28STK241.36818852
29ITK1.34885991
30MAP3K61.30587345
31CDK41.29954393
32PRKD31.27817718
33SGK21.26177547
34SYK1.25849303
35PDGFRB1.25274463
36INSRR1.23856212
37ICK1.22948841
38CHEK21.22251138
39MKNK21.21762438
40PRKCQ1.21732667
41WNK11.21122785
42PASK1.19277932
43TAOK31.18359184
44RIPK41.18226227
45HIPK21.13995732
46STK101.13755011
47CSNK1G31.13687486
48CSNK1G11.13182158
49IRAK11.12379606
50NLK1.11567171
51PLK41.10995900
52CSNK1G21.10287350
53SGK31.10046497
54CASK1.07279999
55STK41.06602098
56RPS6KA51.05945091
57MAP2K71.05750021
58MAP3K41.02412207
59SGK4941.01057813
60SGK2231.01057813
61FGFR30.99918875
62TLK10.98744371
63ACVR1B0.97448204
64CSK0.95227857
65BRD40.94682403
66DMPK0.93944797
67CAMKK20.92884024
68UHMK10.90034498
69NEK60.89854613
70ERBB30.89716133
71TRIM280.88495618
72* MAPK70.87712612
73MAP2K40.86235560
74SIK30.85856355
75PTK2B0.82858978
76GRK10.82384905
77TNIK0.82305725
78KSR10.78404009
79STK30.78278969
80EPHB20.77946097
81MARK20.77725361
82SGK10.77087717
83CHUK0.76695879
84* CDK30.76287539
85OXSR10.76121279
86MKNK10.75941204
87DYRK1B0.67797214
88PIK3CA0.67388099
89PIM10.67038144
90NEK20.66007308
91MAP3K130.65497240
92KSR20.65244996
93RAF10.64996911
94PBK0.64762954
95LATS10.64481371
96NEK90.64479234
97NTRK30.63625650
98STK110.63582561
99PINK10.63162720
100DYRK1A0.62168283
101MAP3K140.61530921
102HCK0.60837551
103CSNK1D0.59276486
104VRK10.59038511
105TAF10.58406849
106TAOK10.56951031
107LCK0.56640142
108PRKCH0.56575616
109CHEK10.56478488
110STK38L0.55928031
111PKN10.55703609
112IRAK20.55155349
113BTK0.54973604
114PRKAA10.53587226
115CDK80.53217624
116RET0.53136386
117NTRK20.52398969
118TYRO30.50962473
119IKBKE0.50781035
120ATM0.50143258
121RPS6KB20.49479915
122PLK20.49288060
123CDC70.48961738
124BCR0.47466987
125DYRK20.46933971
126TGFBR10.45847725
127MAP4K20.45099193
128MAP3K50.44309615
129LYN0.43209118
130PAK60.41562613
131JAK10.41501618
132MAP3K70.40899460
133EIF2AK20.40896978
134DYRK30.39056231
135RPS6KB10.39024007
136EPHA40.38841394
137TTK0.37577154
138CAMK10.36733496
139BUB10.35504427
140PRKG10.35192479
141RPS6KA40.34823338
142AURKA0.34574903
143TEC0.34364438
144BRSK10.34195810
145FGFR10.31652887
146PRKCG0.30947358
147PLK10.30806100
148PLK30.29819928
149PRKCZ0.29497046
150ATR0.28697281

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.30990017
2Phototransduction_Homo sapiens_hsa047444.24474670
3Non-homologous end-joining_Homo sapiens_hsa034502.80520068
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.10740527
5T cell receptor signaling pathway_Homo sapiens_hsa046602.08816687
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.91920225
7B cell receptor signaling pathway_Homo sapiens_hsa046621.81756828
8Mismatch repair_Homo sapiens_hsa034301.75168122
9Systemic lupus erythematosus_Homo sapiens_hsa053221.61468800
10Olfactory transduction_Homo sapiens_hsa047401.59366059
11Basal transcription factors_Homo sapiens_hsa030221.46789135
12Alcoholism_Homo sapiens_hsa050341.45100000
13Circadian rhythm_Homo sapiens_hsa047101.41846929
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34624609
15Hematopoietic cell lineage_Homo sapiens_hsa046401.31404505
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31230019
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.25527301
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25120458
19Endometrial cancer_Homo sapiens_hsa052131.19259310
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15139249
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14090467
22FoxO signaling pathway_Homo sapiens_hsa040681.13359585
23Choline metabolism in cancer_Homo sapiens_hsa052311.12823178
24Hedgehog signaling pathway_Homo sapiens_hsa043401.12678222
25Colorectal cancer_Homo sapiens_hsa052101.12009769
26RNA degradation_Homo sapiens_hsa030181.10877944
27Cell cycle_Homo sapiens_hsa041101.09182999
28Basal cell carcinoma_Homo sapiens_hsa052171.08840010
29Pancreatic cancer_Homo sapiens_hsa052121.07980791
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07149161
31Chemokine signaling pathway_Homo sapiens_hsa040621.07073312
32Prostate cancer_Homo sapiens_hsa052151.05599408
33Linoleic acid metabolism_Homo sapiens_hsa005911.02989845
34RNA transport_Homo sapiens_hsa030131.02319031
35Fanconi anemia pathway_Homo sapiens_hsa034601.00247381
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00194009
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99057737
38Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98917452
39Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98808302
40GABAergic synapse_Homo sapiens_hsa047270.98789138
41Morphine addiction_Homo sapiens_hsa050320.98699639
42DNA replication_Homo sapiens_hsa030300.95553093
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95100621
44Dorso-ventral axis formation_Homo sapiens_hsa043200.94419435
45Antigen processing and presentation_Homo sapiens_hsa046120.92765153
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92404069
47Non-small cell lung cancer_Homo sapiens_hsa052230.92103354
48Long-term potentiation_Homo sapiens_hsa047200.90306058
49Chronic myeloid leukemia_Homo sapiens_hsa052200.89097784
50Autoimmune thyroid disease_Homo sapiens_hsa053200.88931321
51ErbB signaling pathway_Homo sapiens_hsa040120.88246822
52Viral carcinogenesis_Homo sapiens_hsa052030.87190953
53Serotonergic synapse_Homo sapiens_hsa047260.86759210
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86754085
55Osteoclast differentiation_Homo sapiens_hsa043800.84464555
56Cholinergic synapse_Homo sapiens_hsa047250.84460221
57Inositol phosphate metabolism_Homo sapiens_hsa005620.84283609
58Asthma_Homo sapiens_hsa053100.84135818
59Measles_Homo sapiens_hsa051620.84069302
60mRNA surveillance pathway_Homo sapiens_hsa030150.84002917
61Glutamatergic synapse_Homo sapiens_hsa047240.83937609
62p53 signaling pathway_Homo sapiens_hsa041150.83859503
63Dopaminergic synapse_Homo sapiens_hsa047280.83254833
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82941316
65Hepatitis B_Homo sapiens_hsa051610.82783168
66Ribosome_Homo sapiens_hsa030100.82729023
67Graft-versus-host disease_Homo sapiens_hsa053320.82249350
68Type I diabetes mellitus_Homo sapiens_hsa049400.81011547
69HTLV-I infection_Homo sapiens_hsa051660.79449727
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78934375
71Circadian entrainment_Homo sapiens_hsa047130.77312447
72Wnt signaling pathway_Homo sapiens_hsa043100.76635896
73Herpes simplex infection_Homo sapiens_hsa051680.76220943
74MAPK signaling pathway_Homo sapiens_hsa040100.75367534
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72827648
76Ether lipid metabolism_Homo sapiens_hsa005650.72496789
77Allograft rejection_Homo sapiens_hsa053300.72064060
78MicroRNAs in cancer_Homo sapiens_hsa052060.70855837
79Acute myeloid leukemia_Homo sapiens_hsa052210.69536510
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.69506023
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69505642
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69502572
83Amphetamine addiction_Homo sapiens_hsa050310.69337297
84Sphingolipid metabolism_Homo sapiens_hsa006000.68130840
85Taste transduction_Homo sapiens_hsa047420.67904042
86Prolactin signaling pathway_Homo sapiens_hsa049170.67763534
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67490219
88Renal cell carcinoma_Homo sapiens_hsa052110.65930184
89Base excision repair_Homo sapiens_hsa034100.65925104
90Adherens junction_Homo sapiens_hsa045200.64899829
91GnRH signaling pathway_Homo sapiens_hsa049120.64892802
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64680081
93Salivary secretion_Homo sapiens_hsa049700.64677222
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61808646
95cAMP signaling pathway_Homo sapiens_hsa040240.61642113
96Glioma_Homo sapiens_hsa052140.61551834
97Calcium signaling pathway_Homo sapiens_hsa040200.61401564
98Ras signaling pathway_Homo sapiens_hsa040140.61111950
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.60421616
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60421280
101Homologous recombination_Homo sapiens_hsa034400.60259403
102Thyroid hormone synthesis_Homo sapiens_hsa049180.59957373
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59377396
104Insulin secretion_Homo sapiens_hsa049110.59224600
105African trypanosomiasis_Homo sapiens_hsa051430.58503686
106Oxytocin signaling pathway_Homo sapiens_hsa049210.57934230
107Type II diabetes mellitus_Homo sapiens_hsa049300.57316672
108Renin secretion_Homo sapiens_hsa049240.56728211
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56690511
110TGF-beta signaling pathway_Homo sapiens_hsa043500.56224422
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55476445
112Ovarian steroidogenesis_Homo sapiens_hsa049130.55289041
113Leishmaniasis_Homo sapiens_hsa051400.54449024
114Axon guidance_Homo sapiens_hsa043600.54167162
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54013993
116Long-term depression_Homo sapiens_hsa047300.53638987
117Cocaine addiction_Homo sapiens_hsa050300.51444721
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50774954
119Platelet activation_Homo sapiens_hsa046110.50641903
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.50599056
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50161598
122Notch signaling pathway_Homo sapiens_hsa043300.50028694
123Epstein-Barr virus infection_Homo sapiens_hsa051690.49436483
124mTOR signaling pathway_Homo sapiens_hsa041500.49014568
125Oocyte meiosis_Homo sapiens_hsa041140.49005586
126Estrogen signaling pathway_Homo sapiens_hsa049150.47638403
127Synaptic vesicle cycle_Homo sapiens_hsa047210.47538985
128Nicotine addiction_Homo sapiens_hsa050330.47041271
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46978769
130Melanogenesis_Homo sapiens_hsa049160.46749127

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