GLCE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)6.99981285
2post-anal tail morphogenesis (GO:0036342)3.70148708
3retina vasculature morphogenesis in camera-type eye (GO:0061299)3.69130597
4wound healing, spreading of epidermal cells (GO:0035313)3.60281593
5lymphangiogenesis (GO:0001946)3.51291886
6COPI coating of Golgi vesicle (GO:0048205)3.46027794
7Golgi transport vesicle coating (GO:0048200)3.46027794
8negative regulation of fibrinolysis (GO:0051918)3.31893718
9hippo signaling (GO:0035329)3.30977885
10folic acid-containing compound biosynthetic process (GO:0009396)3.29283190
11collagen fibril organization (GO:0030199)3.23256641
12activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.19714729
13positive regulation of nuclease activity (GO:0032075)3.18186385
14regulation of sister chromatid cohesion (GO:0007063)3.09800292
15mitotic sister chromatid cohesion (GO:0007064)3.05573390
16blood vessel maturation (GO:0001955)2.96006080
17one-carbon metabolic process (GO:0006730)2.95119648
18positive regulation of fatty acid beta-oxidation (GO:0032000)2.93717911
19glucocorticoid receptor signaling pathway (GO:0042921)2.93561100
20negative regulation of fatty acid transport (GO:2000192)2.91682305
21negative regulation of chondrocyte differentiation (GO:0032331)2.88773460
22insulin-like growth factor receptor signaling pathway (GO:0048009)2.87943245
23regulation of nuclease activity (GO:0032069)2.86580658
24negative regulation of keratinocyte proliferation (GO:0010839)2.85836928
25gastrulation with mouth forming second (GO:0001702)2.82786506
26cytoplasmic mRNA processing body assembly (GO:0033962)2.76881804
27nuclear pore complex assembly (GO:0051292)2.76188710
28chondrocyte proliferation (GO:0035988)2.74105918
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.73994901
30midgut development (GO:0007494)2.73661326
31neuron remodeling (GO:0016322)2.73636804
32UDP-N-acetylglucosamine metabolic process (GO:0006047)2.73541851
33embryonic foregut morphogenesis (GO:0048617)2.72546289
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72410789
35regulation of transforming growth factor beta2 production (GO:0032909)2.71243784
36chondrocyte development (GO:0002063)2.69901145
37alpha-linolenic acid metabolic process (GO:0036109)2.68549065
38glucosamine-containing compound catabolic process (GO:1901072)2.67591325
39regulation of fibrinolysis (GO:0051917)2.67231086
40pore complex assembly (GO:0046931)2.66383744
41endoplasmic reticulum unfolded protein response (GO:0030968)2.62497868
42urea metabolic process (GO:0019627)2.62449592
43urea cycle (GO:0000050)2.62449592
44regulation of histone H3-K27 methylation (GO:0061085)2.61823678
45regulation of fatty acid beta-oxidation (GO:0031998)2.60869464
46nuclear pore organization (GO:0006999)2.59524770
47lipopolysaccharide biosynthetic process (GO:0009103)2.59002759
48axon extension involved in axon guidance (GO:0048846)2.58318329
49neuron projection extension involved in neuron projection guidance (GO:1902284)2.58318329
50artery development (GO:0060840)2.58211429
51ER-nucleus signaling pathway (GO:0006984)2.56829764
52mitotic chromosome condensation (GO:0007076)2.55918325
53sulfur amino acid catabolic process (GO:0000098)2.55800974
54cellular response to unfolded protein (GO:0034620)2.55473374
55cell adhesion mediated by integrin (GO:0033627)2.55204196
56homocysteine metabolic process (GO:0050667)2.51711826
57positive regulation of SMAD protein import into nucleus (GO:0060391)2.51247699
58regulation of cardioblast differentiation (GO:0051890)2.48492885
59negative regulation of DNA repair (GO:0045738)2.48172060
60regulation of RNA export from nucleus (GO:0046831)2.47737192
61* heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.47585582
62interkinetic nuclear migration (GO:0022027)2.47488440
63positive regulation of RNA splicing (GO:0033120)2.46653373
64ganglion development (GO:0061548)2.46473287
65anterior/posterior axis specification, embryo (GO:0008595)2.46464303
66regulation of cholesterol homeostasis (GO:2000188)2.46034837
67negative regulation of fatty acid biosynthetic process (GO:0045717)2.43953685
68myoblast fusion (GO:0007520)2.43343839
69body morphogenesis (GO:0010171)2.43041470
70endocardial cushion development (GO:0003197)2.42896273
71regulation of keratinocyte proliferation (GO:0010837)2.42653326
72endoplasmic reticulum organization (GO:0007029)2.42506975
73paraxial mesoderm development (GO:0048339)2.42489831
74positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.42340058
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.42200490
76pre-miRNA processing (GO:0031054)2.42083448
77endodermal cell differentiation (GO:0035987)2.40678451
78positive regulation of muscle hypertrophy (GO:0014742)2.39494491
79positive regulation of cardiac muscle hypertrophy (GO:0010613)2.39494491
80negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.39452667
81intestinal absorption (GO:0050892)2.39349695
82sodium ion export (GO:0071436)2.39162818
83stress granule assembly (GO:0034063)2.38534706
84regulation of chondrocyte differentiation (GO:0032330)2.38512068
85COPII vesicle coating (GO:0048208)2.38244183
86SMAD protein complex assembly (GO:0007183)2.37824572
87cytoskeletal anchoring at plasma membrane (GO:0007016)2.35774075
88intestinal epithelial cell development (GO:0060576)2.35731329
89regulation of protein activation cascade (GO:2000257)2.35593263
90positive regulation of endothelial cell differentiation (GO:0045603)2.33578501
91righting reflex (GO:0060013)2.33417362
92inner ear receptor cell development (GO:0060119)2.33276776
93corticosteroid receptor signaling pathway (GO:0031958)2.32715590
94ER overload response (GO:0006983)2.32668915
95somitogenesis (GO:0001756)2.32605937
96substrate-dependent cell migration (GO:0006929)2.31951716
97regulation of mitotic spindle organization (GO:0060236)2.31910696
98peptidyl-glutamic acid carboxylation (GO:0017187)2.31853341
99protein carboxylation (GO:0018214)2.31853341
100cellular response to topologically incorrect protein (GO:0035967)2.31677204
101dicarboxylic acid biosynthetic process (GO:0043650)2.30606075
102protein localization to kinetochore (GO:0034501)2.30186060
103positive regulation of catenin import into nucleus (GO:0035413)2.30047676
104planar cell polarity pathway involved in neural tube closure (GO:0090179)2.30018241
105negative regulation of protein activation cascade (GO:2000258)2.28335622
106vesicle coating (GO:0006901)2.28277288
107labyrinthine layer development (GO:0060711)2.27880898
108regulation of female gonad development (GO:2000194)2.26271297
109mesodermal cell differentiation (GO:0048333)2.26244764
110desmosome organization (GO:0002934)2.26160352
111negative regulation of cell size (GO:0045792)2.26068549
112NLS-bearing protein import into nucleus (GO:0006607)2.25786501
113embryonic process involved in female pregnancy (GO:0060136)2.25239073
114dorsal/ventral axis specification (GO:0009950)2.24810351
115endothelium development (GO:0003158)2.24498590
116plasma membrane repair (GO:0001778)2.23715242
117regulation of complement activation (GO:0030449)2.23549853
118regulation of SMAD protein import into nucleus (GO:0060390)2.22831966
119regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.22418747
120regulation of glomerular filtration (GO:0003093)2.22194270
121positive regulation of mitochondrial membrane permeability (GO:0035794)2.22024257
122macroautophagy (GO:0016236)2.21084649
123response to endoplasmic reticulum stress (GO:0034976)2.21018698
124fibrinolysis (GO:0042730)2.20330396
125negative regulation of sodium ion transport (GO:0010766)2.18836046
126segmentation (GO:0035282)2.18432932
127axonal fasciculation (GO:0007413)2.18391789
128bone trabecula formation (GO:0060346)2.17697196
129embryonic body morphogenesis (GO:0010172)2.17591067
130glomerular visceral epithelial cell development (GO:0072015)2.17540465
131regulation of steroid hormone biosynthetic process (GO:0090030)2.17365077
132positive regulation of protein autophosphorylation (GO:0031954)2.17041180
133bundle of His cell to Purkinje myocyte communication (GO:0086069)2.16985331
134epoxygenase P450 pathway (GO:0019373)2.15993664
135positive regulation of hormone biosynthetic process (GO:0046886)2.14364166
136layer formation in cerebral cortex (GO:0021819)2.13564542
137negative regulation of hormone biosynthetic process (GO:0032353)2.12742227
138substrate adhesion-dependent cell spreading (GO:0034446)2.12606122
139negative regulation of hormone metabolic process (GO:0032351)2.11365580
140regulation of Rac protein signal transduction (GO:0035020)2.10537809
141heart field specification (GO:0003128)2.10000500
142secondary heart field specification (GO:0003139)2.10000500
143acrosome assembly (GO:0001675)2.06241388
144renal system process involved in regulation of blood volume (GO:0001977)2.05786857
145protein localization to cell surface (GO:0034394)2.05351766
146embryonic retina morphogenesis in camera-type eye (GO:0060059)2.04882832
147gap junction assembly (GO:0016264)2.04192712
148wound healing, spreading of cells (GO:0044319)2.03550999
149smooth muscle tissue development (GO:0048745)2.02456988
150hemidesmosome assembly (GO:0031581)2.02309875
151vocalization behavior (GO:0071625)2.01972599
152dendritic spine organization (GO:0097061)1.98908667
153positive regulation of dendritic spine morphogenesis (GO:0061003)1.98107883
154endothelial cell morphogenesis (GO:0001886)1.98006550
155negative chemotaxis (GO:0050919)1.97876777
156Leydig cell differentiation (GO:0033327)1.97611999
157L-serine transport (GO:0015825)1.97305431
158dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.95339988
159glomerular epithelial cell development (GO:0072310)1.94922316
160endothelial tube morphogenesis (GO:0061154)1.94515411
161morphogenesis of an endothelium (GO:0003159)1.94515411
162limb bud formation (GO:0060174)1.94485534
163positive regulation of cell size (GO:0045793)1.93822842
164vascular smooth muscle contraction (GO:0014829)1.93713663
165negative regulation of stem cell proliferation (GO:2000647)1.93152950
166glutamate secretion (GO:0014047)1.92174110
167negative regulation of cartilage development (GO:0061037)1.90076888
168regulation of axon extension involved in axon guidance (GO:0048841)1.89798770
169embryonic heart tube development (GO:0035050)1.88738935
170regulation of cell proliferation involved in heart morphogenesis (GO:2000136)1.87418913
171regulation of centriole replication (GO:0046599)1.87141978
172response to lead ion (GO:0010288)1.86432009
173negative regulation of cell-matrix adhesion (GO:0001953)1.86410104
174outflow tract septum morphogenesis (GO:0003148)1.86102830
175regulation of endothelial cell differentiation (GO:0045601)1.85337046
176coronary vasculature morphogenesis (GO:0060977)1.85332514
177ephrin receptor signaling pathway (GO:0048013)1.83438313
178sympathetic nervous system development (GO:0048485)1.83180608
179cell-cell junction assembly (GO:0007043)1.82624745
180regulation of branching involved in salivary gland morphogenesis (GO:0060693)1.82524316
181regulation of axon guidance (GO:1902667)1.82136487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human6.96713957
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.24012136
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.98001373
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.54135606
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.46584445
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.40629269
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.16468042
8HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.14664322
9E2F7_22180533_ChIP-Seq_HELA_Human2.87354787
10CLOCK_20551151_ChIP-Seq_293T_Human2.67400356
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63488860
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59903919
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41173823
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.38701146
15GBX2_23144817_ChIP-Seq_PC3_Human2.33874379
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.33632908
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.28238267
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14023047
19TAF15_26573619_Chip-Seq_HEK293_Human2.13163401
20AR_21572438_ChIP-Seq_LNCaP_Human2.09360460
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06747200
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.99384513
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98689109
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.96509340
25GATA1_22025678_ChIP-Seq_K562_Human1.90580330
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87196514
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85346497
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84601638
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81901338
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80994328
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.79733941
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78358709
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.77846297
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76249014
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73177465
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72593553
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.71744762
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.70393486
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.66635467
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66111360
41FUS_26573619_Chip-Seq_HEK293_Human1.65542799
42* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.65390882
43* P300_19829295_ChIP-Seq_ESCs_Human1.63309345
44BRD4_25478319_ChIP-Seq_HGPS_Human1.62769367
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.60754096
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.60401206
47AR_21909140_ChIP-Seq_LNCAP_Human1.59286836
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58725535
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58313479
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.57842036
51ZNF263_19887448_ChIP-Seq_K562_Human1.57802014
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54925994
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.53615791
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50279355
55* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47069502
56TP53_18474530_ChIP-ChIP_U2OS_Human1.45959106
57EWS_26573619_Chip-Seq_HEK293_Human1.43287420
58AHR_22903824_ChIP-Seq_MCF-7_Human1.42814173
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40974115
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.40569872
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.39816486
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39739100
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37148808
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36733867
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.36658278
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36494865
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.35685967
68TP53_16413492_ChIP-PET_HCT116_Human1.34452360
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.32958112
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32730680
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32026625
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31525987
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30901151
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.29839248
75KDM2B_26808549_Chip-Seq_K562_Human1.29546084
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28043865
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26930830
78CHD1_26751641_Chip-Seq_LNCaP_Human1.26544367
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25832713
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25790310
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.24360286
82STAT3_23295773_ChIP-Seq_U87_Human1.24095724
83* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23042212
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22689217
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.22552187
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22182342
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19366314
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19283581
89* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18471435
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17643895
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.17449258
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16087052
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15806259
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15662344
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15374969
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.14891546
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.14309140
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14202554
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13993569
100* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13962868
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13952497
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13938242
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13468011
104TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11695668
105FOXA2_19822575_ChIP-Seq_HepG2_Human1.11390835
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11073048
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11050757
108TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10871206
109* TP63_23658742_ChIP-Seq_EP156T_Human1.10678714
110TCF4_18268006_ChIP-ChIP_LS174T_Human1.09716694
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09696699
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09177975
113CREB1_26743006_Chip-Seq_LNCaP_Human1.08436450
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07849774
115IGF1R_20145208_ChIP-Seq_DFB_Human1.07216370
116* TCF4_23295773_ChIP-Seq_U87_Human1.06955709
117CJUN_26792858_Chip-Seq_BT549_Human1.06468523
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06058214
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06022564
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05753483
121* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05462102
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05280071
123AR_25329375_ChIP-Seq_VCAP_Human1.05053970
124* TCF4_22108803_ChIP-Seq_LS180_Human1.04035403
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03623680
126* CDX2_22108803_ChIP-Seq_LS180_Human1.02800792
127ISL1_27105846_Chip-Seq_CPCs_Mouse1.02311626
128* SOX2_21211035_ChIP-Seq_LN229_Gbm1.01890957
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01824062
130EP300_21415370_ChIP-Seq_HL-1_Mouse1.01615515
131PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01435461
132RXR_22108803_ChIP-Seq_LS180_Human1.01252394
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00809176
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00710017
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00635814
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00176949
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.99886411
138* SOX2_20726797_ChIP-Seq_SW620_Human0.99365997
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99077260
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98871576
141* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97456711
142SOX9_26525672_Chip-Seq_HEART_Mouse0.96989673
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95518604
144CBP_20019798_ChIP-Seq_JUKART_Human0.95518604
145SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95445373
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95259483
147KDM2B_26808549_Chip-Seq_DND41_Human0.93439452
148PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93344820
149* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92979132
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91947113
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91687711
152ATF3_27146783_Chip-Seq_COLON_Human0.91448183
153EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90444892
154* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90371368
155TCF7_22412390_ChIP-Seq_EML_Mouse0.88270557
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87860216
157SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87131691
158* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86425628
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86316447
160SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85789825
161SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85789825
162NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84785202
163NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84785202
164GATA6_25053715_ChIP-Seq_YYC3_Human0.84689409
165ELK3_25401928_ChIP-Seq_HUVEC_Human0.84063151
166HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83656222
167E2F4_17652178_ChIP-ChIP_JURKAT_Human0.83601756
168* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82454826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.68535827
2MP0008438_abnormal_cutaneous_collagen4.52814856
3MP0005360_urolithiasis4.32832198
4MP0010368_abnormal_lymphatic_system3.39881621
5MP0010352_gastrointestinal_tract_polyps3.04252051
6MP0005275_abnormal_skin_tensile3.04005808
7MP0009384_cardiac_valve_regurgitation2.91673220
8MP0010234_abnormal_vibrissa_follicle2.90627765
9MP0005503_abnormal_tendon_morphology2.85973660
10MP0005076_abnormal_cell_differentiation2.62728830
11MP0001879_abnormal_lymphatic_vessel2.15045567
12MP0002139_abnormal_hepatobiliary_system2.14810547
13MP0003091_abnormal_cell_migration1.99376192
14MP0005365_abnormal_bile_salt1.99089987
15MP0003252_abnormal_bile_duct1.98149689
16MP0003279_aneurysm1.97328218
17MP0005187_abnormal_penis_morphology1.87615565
18MP0008961_abnormal_basal_metabolism1.77952254
19MP0009780_abnormal_chondrocyte_physiolo1.75826470
20MP0002932_abnormal_joint_morphology1.71836407
21MP0005085_abnormal_gallbladder_physiolo1.64436706
22MP0005508_abnormal_skeleton_morphology1.61459839
23MP0001299_abnormal_eye_distance/1.60930384
24MP0000003_abnormal_adipose_tissue1.56692990
25MP0010678_abnormal_skin_adnexa1.54495796
26MP0003566_abnormal_cell_adhesion1.53768681
27MP0000569_abnormal_digit_pigmentation1.52098889
28MP0000733_abnormal_muscle_development1.51693554
29MP0003123_paternal_imprinting1.50842985
30MP0003890_abnormal_embryonic-extraembry1.50259413
31MP0008057_abnormal_DNA_replication1.47638155
32MP0005257_abnormal_intraocular_pressure1.47469301
33MP0009053_abnormal_anal_canal1.45054241
34MP0009697_abnormal_copulation1.44449924
35* MP0002896_abnormal_bone_mineralization1.44204458
36MP0004270_analgesia1.37709920
37MP0002877_abnormal_melanocyte_morpholog1.37173930
38MP0005409_darkened_coat_color1.34791943
39MP0002060_abnormal_skin_morphology1.31817285
40MP0003950_abnormal_plasma_membrane1.30455591
41MP0006054_spinal_hemorrhage1.30238792
42MP0004197_abnormal_fetal_growth/weight/1.25147851
43MP0000428_abnormal_craniofacial_morphol1.21697670
44MP0003283_abnormal_digestive_organ1.21333567
45MP0003942_abnormal_urinary_system1.20270825
46MP0004272_abnormal_basement_membrane1.18323575
47MP0000767_abnormal_smooth_muscle1.17770994
48MP0001849_ear_inflammation1.16840861
49MP0004233_abnormal_muscle_weight1.15985205
50MP0001986_abnormal_taste_sensitivity1.15945733
51MP0003115_abnormal_respiratory_system1.14506253
52MP0004147_increased_porphyrin_level1.13734843
53MP0010307_abnormal_tumor_latency1.13713518
54MP0002084_abnormal_developmental_patter1.10555240
55MP0010030_abnormal_orbit_morphology1.09843273
56MP0000383_abnormal_hair_follicle1.09658291
57MP0010329_abnormal_lipoprotein_level1.09056164
58MP0005220_abnormal_exocrine_pancreas1.08824342
59MP0003121_genomic_imprinting1.07905114
60MP0001944_abnormal_pancreas_morphology1.07884137
61MP0004484_altered_response_of1.07821613
62MP0000465_gastrointestinal_hemorrhage1.07369790
63MP0000762_abnormal_tongue_morphology1.06413821
64* MP0002111_abnormal_tail_morphology1.06343509
65MP0002102_abnormal_ear_morphology1.06332103
66MP0002295_abnormal_pulmonary_circulatio1.05863855
67MP0000534_abnormal_ureter_morphology1.05107144
68MP0006138_congestive_heart_failure1.04698052
69MP0003122_maternal_imprinting1.03845521
70MP0009703_decreased_birth_body1.03382860
71MP0005408_hypopigmentation1.03149686
72MP0000350_abnormal_cell_proliferation1.01812532
73MP0002098_abnormal_vibrissa_morphology1.01254459
74MP0003935_abnormal_craniofacial_develop1.00495393
75* MP0003755_abnormal_palate_morphology1.00276461
76MP0003941_abnormal_skin_development0.99963926
77MP0000432_abnormal_head_morphology0.99572112
78MP0008875_abnormal_xenobiotic_pharmacok0.98399781
79MP0000163_abnormal_cartilage_morphology0.98199882
80MP0010094_abnormal_chromosome_stability0.97475249
81MP0004264_abnormal_extraembryonic_tissu0.97124944
82MP0002751_abnormal_autonomic_nervous0.96724685
83MP0005023_abnormal_wound_healing0.96696204
84MP0003718_maternal_effect0.96586207
85MP0001666_abnormal_nutrient_absorption0.95056464
86MP0002697_abnormal_eye_size0.93995175
87MP0000049_abnormal_middle_ear0.93815775
88MP0002735_abnormal_chemical_nociception0.93363245
89MP0000537_abnormal_urethra_morphology0.92467817
90MP0004859_abnormal_synaptic_plasticity0.92115018
91MP0003385_abnormal_body_wall0.91936524
92MP0004782_abnormal_surfactant_physiolog0.91469825
93MP0009672_abnormal_birth_weight0.90042234
94MP0008770_decreased_survivor_rate0.90028137
95MP0009250_abnormal_appendicular_skeleto0.89784100
96MP0004215_abnormal_myocardial_fiber0.89165976
97MP0000467_abnormal_esophagus_morphology0.88255294
98MP0003806_abnormal_nucleotide_metabolis0.88019065
99MP0002085_abnormal_embryonic_tissue0.87480751
100MP0003111_abnormal_nucleus_morphology0.86737189
101MP0005248_abnormal_Harderian_gland0.85640058
102MP0002116_abnormal_craniofacial_bone0.84981276
103MP0002796_impaired_skin_barrier0.84421732
104MP0003937_abnormal_limbs/digits/tail_de0.84046137
105MP0003868_abnormal_feces_composition0.82128658
106MP0002086_abnormal_extraembryonic_tissu0.81768409
107* MP0002114_abnormal_axial_skeleton0.81392107
108MP0001270_distended_abdomen0.81143633
109MP0000516_abnormal_urinary_system0.80848416
110MP0005367_renal/urinary_system_phenotyp0.80848416
111MP0000462_abnormal_digestive_system0.80395530
112MP0000613_abnormal_salivary_gland0.80103116
113MP0005623_abnormal_meninges_morphology0.79424029
114MP0005621_abnormal_cell_physiology0.79423492
115MP0003119_abnormal_digestive_system0.79403167
116MP0002233_abnormal_nose_morphology0.79004687
117MP0002234_abnormal_pharynx_morphology0.78934789
118MP0005395_other_phenotype0.78808089
119MP0008932_abnormal_embryonic_tissue0.78509259
120MP0003984_embryonic_growth_retardation0.78436933
121MP0001177_atelectasis0.78173378
122MP0003699_abnormal_female_reproductive0.76834147
123MP0002108_abnormal_muscle_morphology0.76350380
124MP0002088_abnormal_embryonic_growth/wei0.76162372
125* MP0002113_abnormal_skeleton_development0.75106597
126* MP0005197_abnormal_uvea_morphology0.74016621
127MP0001915_intracranial_hemorrhage0.73926086
128MP0002092_abnormal_eye_morphology0.73868480
129MP0000427_abnormal_hair_cycle0.73127967
130MP0005083_abnormal_biliary_tract0.73065739
131MP0002925_abnormal_cardiovascular_devel0.72557137
132MP0003300_gastrointestinal_ulcer0.72299506
133MP0005167_abnormal_blood-brain_barrier0.72121663
134MP0005375_adipose_tissue_phenotype0.71234108
135MP0001661_extended_life_span0.71172675
136MP0004185_abnormal_adipocyte_glucose0.70368383
137MP0005501_abnormal_skin_physiology0.70101145
138MP0000639_abnormal_adrenal_gland0.70077210
139MP0001672_abnormal_embryogenesis/_devel0.70045867
140MP0005380_embryogenesis_phenotype0.70045867
141MP0004957_abnormal_blastocyst_morpholog0.69756602
142MP0002734_abnormal_mechanical_nocicepti0.69672317
143MP0002177_abnormal_outer_ear0.69412605
144MP0000647_abnormal_sebaceous_gland0.67922689
145MP0001614_abnormal_blood_vessel0.67315107
146MP0001730_embryonic_growth_arrest0.65932813
147MP0002128_abnormal_blood_circulation0.64468379
148MP0002160_abnormal_reproductive_system0.64121026
149MP0003567_abnormal_fetal_cardiomyocyte0.62057044
150MP0003828_pulmonary_edema0.61804873

Predicted human phenotypes

RankGene SetZ-score
1Anomalous pulmonary venous return (HP:0010772)4.95451740
2Protrusio acetabuli (HP:0003179)4.89882824
3Pseudobulbar signs (HP:0002200)4.47938077
4Abnormality of the pulmonary veins (HP:0011718)4.46554206
5Premature rupture of membranes (HP:0001788)3.88251571
6Shallow orbits (HP:0000586)3.56015568
7Abnormality of the odontoid process (HP:0003310)3.41058477
8Short 4th metacarpal (HP:0010044)3.34626188
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.34626188
10Hematochezia (HP:0002573)3.28771223
11Ankle contracture (HP:0006466)3.16523868
12Abnormality of the lower motor neuron (HP:0002366)3.14403354
13Myelomeningocele (HP:0002475)3.11240792
14Deep venous thrombosis (HP:0002625)3.05676313
15Hemivertebrae (HP:0002937)3.02488741
16Abnormality of the intervertebral disk (HP:0005108)2.95062591
17Mitral valve prolapse (HP:0001634)2.75624694
18Abnormality of the 4th metacarpal (HP:0010012)2.73395599
19Aortic dissection (HP:0002647)2.62930768
20Conjugated hyperbilirubinemia (HP:0002908)2.60789547
21Wrist flexion contracture (HP:0001239)2.58789994
22Cervical subluxation (HP:0003308)2.56118686
23Termporal pattern (HP:0011008)2.50144593
24Insidious onset (HP:0003587)2.50144593
25Aortic aneurysm (HP:0004942)2.48749175
26Cerebral aneurysm (HP:0004944)2.48215235
27Soft skin (HP:0000977)2.44750240
28Vertebral fusion (HP:0002948)2.43329862
29Increased mean platelet volume (HP:0011877)2.41060893
30Turricephaly (HP:0000262)2.40065362
31Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.38954010
32Broad metatarsal (HP:0001783)2.37006757
33Dilatation of the ascending aorta (HP:0005111)2.35372674
34Bladder diverticulum (HP:0000015)2.32037208
35Long toe (HP:0010511)2.26647079
36Curly hair (HP:0002212)2.26156302
37Arterial tortuosity (HP:0005116)2.23237081
38Genu recurvatum (HP:0002816)2.23160780
39Rectal prolapse (HP:0002035)2.17171426
40Postural tremor (HP:0002174)2.16625654
41Right ventricular cardiomyopathy (HP:0011663)2.15476815
42Vascular tortuosity (HP:0004948)2.14171305
43Overgrowth (HP:0001548)2.11468454
44Distal upper limb amyotrophy (HP:0007149)2.10041133
45Upper limb amyotrophy (HP:0009129)2.10041133
46Abnormal auditory evoked potentials (HP:0006958)2.09263603
47Enlarged penis (HP:0000040)2.09111741
48Aneurysm (HP:0002617)2.08564331
49Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.08251532
50Wormian bones (HP:0002645)2.07769588
51Striae distensae (HP:0001065)2.07736489
52Bowel diverticulosis (HP:0005222)2.07343691
53Osteolytic defects of the hand bones (HP:0009699)2.06776454
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.06776454
55Hand muscle atrophy (HP:0009130)2.05413917
56Abnormality of the intrinsic pathway (HP:0010989)2.04535358
57Atonic seizures (HP:0010819)2.03809409
58Hyperextensible skin (HP:0000974)1.95948905
59Buphthalmos (HP:0000557)1.93391367
60Neoplasm of the peripheral nervous system (HP:0100007)1.93219279
61Abnormality of monocarboxylic acid metabolism (HP:0010996)1.90519145
62Abnormal delivery (HP:0001787)1.89566325
63Atrophic scars (HP:0001075)1.89551787
64Peritonitis (HP:0002586)1.88909861
65Hyperventilation (HP:0002883)1.88346721
66Malignant gastrointestinal tract tumors (HP:0006749)1.87653127
67Gastrointestinal carcinoma (HP:0002672)1.87653127
68Skull defect (HP:0001362)1.87495226
69Thyroid carcinoma (HP:0002890)1.87159002
70Microglossia (HP:0000171)1.86996671
71Neonatal respiratory distress (HP:0002643)1.85417519
72Hypoplasia of the maxilla (HP:0000327)1.85410504
73Follicular hyperkeratosis (HP:0007502)1.85210421
74Asymmetry of the thorax (HP:0001555)1.84392374
75Papillary thyroid carcinoma (HP:0002895)1.83438135
76Neonatal death (HP:0003811)1.82779422
77Nonimmune hydrops fetalis (HP:0001790)1.81744307
78Subacute progressive viral hepatitis (HP:0006572)1.80734659
79Spinal cord compression (HP:0002176)1.80604775
80Colon cancer (HP:0003003)1.80099891
81Abnormal vertebral ossification (HP:0100569)1.78699329
82Exotropia (HP:0000577)1.78455758
83Vertebral arch anomaly (HP:0008438)1.78028615
84Cerebral hemorrhage (HP:0001342)1.77030364
85Facial hemangioma (HP:0000329)1.76920323
86Cortical dysplasia (HP:0002539)1.76563849
87Pheochromocytoma (HP:0002666)1.75883801
88Absent eyebrow (HP:0002223)1.75756762
89Camptodactyly of toe (HP:0001836)1.75754980
90Pulmonic stenosis (HP:0001642)1.73578730
91Hypoplastic ischia (HP:0003175)1.72861056
92Slender long bone (HP:0003100)1.72263934
93Intrahepatic cholestasis (HP:0001406)1.71544618
94Upper motor neuron abnormality (HP:0002127)1.70684403
95Short nail (HP:0001799)1.70639028
96Ependymoma (HP:0002888)1.69122945
97Blue sclerae (HP:0000592)1.69009329
98Abnormality of the astrocytes (HP:0100707)1.68420530
99Astrocytoma (HP:0009592)1.68420530
100Action tremor (HP:0002345)1.68260560
101Transitional cell carcinoma of the bladder (HP:0006740)1.68115173
102Macroorchidism (HP:0000053)1.68076587
103Spondylolisthesis (HP:0003302)1.67556750
104Hepatoblastoma (HP:0002884)1.67211190
105Bladder neoplasm (HP:0009725)1.67170275
106Bladder carcinoma (HP:0002862)1.67170275
107Ectopia lentis (HP:0001083)1.66811254
108Conjunctival telangiectasia (HP:0000524)1.66721993
109Abnormal platelet volume (HP:0011876)1.66338315
110Mitral stenosis (HP:0001718)1.65827343
111Mesomelia (HP:0003027)1.65826979
112Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.65442723
113Abnormality of the fetal cardiovascular system (HP:0010948)1.65159382
114Abnormal umbilical cord blood vessels (HP:0011403)1.65159382
115Single umbilical artery (HP:0001195)1.65159382
116Narrow palate (HP:0000189)1.65066343
117Uterine leiomyosarcoma (HP:0002891)1.64991823
118Leiomyosarcoma (HP:0100243)1.64991823
119Hypopigmentation of the fundus (HP:0007894)1.64887966
120Spinal cord lesions (HP:0100561)1.64878785
121Syringomyelia (HP:0003396)1.64878785
122Intestinal polyposis (HP:0200008)1.64772744
123Broad long bones (HP:0005622)1.64735614
124Xanthomatosis (HP:0000991)1.64735458
125Skin nodule (HP:0200036)1.64225036
126Spina bifida occulta (HP:0003298)1.63311682
127Breech presentation (HP:0001623)1.63107471
128Spinal rigidity (HP:0003306)1.62861681
129Thoracolumbar scoliosis (HP:0002944)1.62672988
130Glioma (HP:0009733)1.62670458
131Neoplasm of the oral cavity (HP:0100649)1.62276681
132Hypoplastic labia majora (HP:0000059)1.62245688
133Deviation of the hallux (HP:0010051)1.62065761
134Broad ribs (HP:0000885)1.61306755
135Broad thumb (HP:0011304)1.61247118
136Cutaneous finger syndactyly (HP:0010554)1.61038098
137Biliary tract neoplasm (HP:0100574)1.60891350
138Sensory axonal neuropathy (HP:0003390)1.59867140
139Midline defect of the nose (HP:0004122)1.59833928
140Joint laxity (HP:0001388)1.59414839
141Ankyloglossia (HP:0010296)1.59125082
142Neonatal short-limb short stature (HP:0008921)1.58243009
143Menorrhagia (HP:0000132)1.58197496
144Exostoses (HP:0100777)1.58065571
145Abnormal foot bone ossification (HP:0010675)1.57223444
146Bifid uvula (HP:0000193)1.57178320
147Abnormality of carpal bone ossification (HP:0006257)1.56753559
148Abnormality of the ischium (HP:0003174)1.56741390
149Urinary urgency (HP:0000012)1.56483969
150Lymphangioma (HP:0100764)1.56469410
151Hallux valgus (HP:0001822)1.56461208
152Congenital glaucoma (HP:0001087)1.56452206
153Broad phalanx (HP:0006009)1.56160713
154Hypobetalipoproteinemia (HP:0003563)1.55740884
155Abnormal hand bone ossification (HP:0010660)1.55544012
156Abnormality of the labia majora (HP:0012881)1.55369568
157Abnormality of the labia minora (HP:0012880)1.55272894
158Hemangiomatosis (HP:0007461)1.54464089
159Intestinal polyp (HP:0005266)1.54425487
160Submucous cleft hard palate (HP:0000176)1.54367571
161Radial bowing (HP:0002986)1.54044419
162Absent speech (HP:0001344)1.53831389
163Large earlobe (HP:0009748)1.53743931
164Short clavicles (HP:0000894)1.53668358
165Relative macrocephaly (HP:0004482)1.53233642
166Abnormality of oral frenula (HP:0000190)1.53105264
167Visceral angiomatosis (HP:0100761)1.52567844
168Open mouth (HP:0000194)1.52403911
169Decreased lacrimation (HP:0000633)1.52382833
170Tetraparesis (HP:0002273)1.52375466
171Subcapsular cataract (HP:0000523)1.51702845
172Bifid tongue (HP:0010297)1.50098895
173Knee flexion contracture (HP:0006380)1.49756065
174Horizontal nystagmus (HP:0000666)1.48848179
175Aplasia cutis congenita (HP:0001057)1.48770844
176Neoplasm of the small intestine (HP:0100833)1.47992967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.98411049
2TIE14.51005328
3LATS13.78042500
4BRD43.70542075
5PBK2.81872026
6TRIM282.68156147
7CASK2.48699052
8MST1R2.33161278
9SCYL22.14909146
10LATS22.13945393
11STK392.12466635
12PDGFRA1.98301774
13TRIB31.98205980
14TAOK31.91783687
15MAP3K91.91580476
16DDR21.87374876
17TGFBR21.84098014
18PKN21.76477519
19EEF2K1.68556085
20FRK1.68006505
21KSR21.66622807
22BCR1.63981478
23BMPR1B1.62491848
24PNCK1.61286865
25MAP3K121.61006013
26MARK11.60584779
27MAP3K61.57645595
28MOS1.56706077
29EIF2AK31.55347306
30KSR11.52152645
31PRKD31.51458274
32EPHA41.50926994
33CDC71.47711493
34TGFBR11.46580326
35EIF2AK11.44072843
36STK31.35935971
37EPHB21.33644945
38MST41.29601239
39MAP3K41.28676427
40CDK91.27882001
41TNIK1.25102872
42TTN1.23947393
43SIK11.23363457
44CDK61.22091223
45MAP3K21.21255441
46OXSR11.20814776
47STK101.20315971
48RIPK11.19531476
49TSSK61.19343874
50SRPK11.17725561
51MTOR1.16413174
52RET1.15359663
53FLT31.14230926
54MELK1.13729071
55ERN11.13227259
56PTK61.06871227
57NTRK11.05385820
58LMTK21.05154208
59NEK21.04843990
60ERBB30.99859340
61MAP2K40.98461860
62ERBB40.98192740
63CAMK1D0.97668181
64NTRK30.96173353
65PTK20.95211240
66NEK10.95121521
67PAK40.94786973
68CAMK1G0.85479378
69ALK0.85435170
70FGFR10.80970655
71EPHA30.80443091
72NEK90.80002840
73PRKCE0.78277634
74MET0.77797225
75RPS6KA20.77194528
76PLK20.75419086
77TRPM70.72875981
78TAOK10.72269411
79FER0.70648234
80FGFR20.69187344
81TTK0.69027362
82MINK10.68331467
83DYRK30.68077366
84PAK30.67757756
85RAF10.67270497
86MAP2K10.66856953
87MAP2K70.65982122
88DYRK1B0.64177534
89MAP4K20.63930043
90BRSK20.61847810
91CSNK1G10.61256808
92TAF10.61189014
93NEK60.60792766
94PAK20.59971337
95AKT20.59658235
96PAK60.59181129
97MAPKAPK50.58619011
98LRRK20.58527508
99HIPK20.58103544
100CCNB10.55995959
101CAMK2B0.55501673
102ROCK10.54953680
103STK38L0.54662217
104PLK30.54015496
105PLK40.53654104
106PLK10.52170230
107BMX0.51355016
108STK110.51131764
109MYLK0.51051079
110CAMKK10.51032394
111MAP3K80.50623563
112ZAK0.50417474
113CSNK1G20.50286454
114WNK30.50232295
115CDK180.50229247
116MAPK130.49724790
117STK240.49322038
118CDK80.49255714
119EPHA20.49109120
120MAP3K50.48680174
121RPS6KB10.45978744
122YES10.45852360
123SGK20.45322354
124DYRK1A0.45133669
125BUB10.44668586
126ABL20.44248849
127BMPR20.44230623
128AKT30.44150154
129CSNK1G30.43595880
130DAPK20.42935509
131ICK0.42806536
132PRKCH0.41877445
133PDGFRB0.41575682
134CDK70.40692797
135WEE10.40655301
136BRAF0.40536475
137ATM0.38984732
138CDK150.37253096
139CDK20.36335489
140AURKB0.36142301
141PRKDC0.35923857
142RPS6KC10.35816853
143RPS6KL10.35816853
144SIK30.35224106
145INSRR0.34425971
146MAPKAPK30.34030167
147CAMK2G0.33231428
148GSK3A0.32765926
149MAPK10.32695566
150STK380.31974872
151MAPK140.31594612
152ACVR1B0.31347204
153MAP3K100.30350157
154CSNK1A1L0.30333329
155BRSK10.30314619
156MAPK100.30119997
157PRKAA10.30077412
158CDK10.29829768

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.93149013
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.78048484
3Arginine biosynthesis_Homo sapiens_hsa002202.18604269
4Selenocompound metabolism_Homo sapiens_hsa004502.14122409
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99627389
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94301491
7Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79161391
8Bile secretion_Homo sapiens_hsa049761.68154749
9Bladder cancer_Homo sapiens_hsa052191.65498158
10mTOR signaling pathway_Homo sapiens_hsa041501.58247407
11Lysine degradation_Homo sapiens_hsa003101.52377968
12Complement and coagulation cascades_Homo sapiens_hsa046101.51847676
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.46474366
14MicroRNAs in cancer_Homo sapiens_hsa052061.41073375
15* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40117293
16Adherens junction_Homo sapiens_hsa045201.38337147
17Folate biosynthesis_Homo sapiens_hsa007901.38312803
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33147846
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32003674
20Colorectal cancer_Homo sapiens_hsa052101.31924269
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30523046
22Vitamin B6 metabolism_Homo sapiens_hsa007501.27940229
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22270350
24Endometrial cancer_Homo sapiens_hsa052131.21468383
25Glioma_Homo sapiens_hsa052141.20466369
26ECM-receptor interaction_Homo sapiens_hsa045121.18481063
27Chronic myeloid leukemia_Homo sapiens_hsa052201.18117691
28Proteoglycans in cancer_Homo sapiens_hsa052051.17533296
29Cell cycle_Homo sapiens_hsa041101.17124578
30Hippo signaling pathway_Homo sapiens_hsa043901.15806417
31Ovarian steroidogenesis_Homo sapiens_hsa049131.15584257
32TGF-beta signaling pathway_Homo sapiens_hsa043501.13824528
33Tight junction_Homo sapiens_hsa045301.12867469
34Tryptophan metabolism_Homo sapiens_hsa003801.12848523
35Non-homologous end-joining_Homo sapiens_hsa034501.11929642
36Focal adhesion_Homo sapiens_hsa045101.11137029
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10602934
38Insulin resistance_Homo sapiens_hsa049311.10124912
39Type II diabetes mellitus_Homo sapiens_hsa049301.07756471
40Fatty acid elongation_Homo sapiens_hsa000621.06926553
41Fatty acid degradation_Homo sapiens_hsa000711.05978535
42Sphingolipid metabolism_Homo sapiens_hsa006001.03661804
43Thyroid cancer_Homo sapiens_hsa052161.03130686
44Dorso-ventral axis formation_Homo sapiens_hsa043201.03009851
45One carbon pool by folate_Homo sapiens_hsa006700.99576163
46Circadian rhythm_Homo sapiens_hsa047100.98911876
47Histidine metabolism_Homo sapiens_hsa003400.95906834
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95213619
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.94411852
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93918008
51Non-small cell lung cancer_Homo sapiens_hsa052230.93510675
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93258118
53Pancreatic cancer_Homo sapiens_hsa052120.92659860
54Pyruvate metabolism_Homo sapiens_hsa006200.92460065
55N-Glycan biosynthesis_Homo sapiens_hsa005100.91601905
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90348525
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.89744341
58p53 signaling pathway_Homo sapiens_hsa041150.89693814
59Propanoate metabolism_Homo sapiens_hsa006400.89645862
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89341740
61Prostate cancer_Homo sapiens_hsa052150.89019220
62Vibrio cholerae infection_Homo sapiens_hsa051100.88136406
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87536089
64FoxO signaling pathway_Homo sapiens_hsa040680.87441580
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86790667
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85595592
67Wnt signaling pathway_Homo sapiens_hsa043100.85379121
68Small cell lung cancer_Homo sapiens_hsa052220.85001461
69Estrogen signaling pathway_Homo sapiens_hsa049150.84447656
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82658806
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82368530
72Arginine and proline metabolism_Homo sapiens_hsa003300.82051398
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81196544
74Melanoma_Homo sapiens_hsa052180.79186250
75Thyroid hormone synthesis_Homo sapiens_hsa049180.78462471
76PPAR signaling pathway_Homo sapiens_hsa033200.77810423
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76744162
78Hedgehog signaling pathway_Homo sapiens_hsa043400.76026933
79Protein digestion and absorption_Homo sapiens_hsa049740.75968473
80Oocyte meiosis_Homo sapiens_hsa041140.75930327
81Basal cell carcinoma_Homo sapiens_hsa052170.75541198
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75203741
83Glutamatergic synapse_Homo sapiens_hsa047240.74459695
84Nicotine addiction_Homo sapiens_hsa050330.74296308
85Fatty acid biosynthesis_Homo sapiens_hsa000610.73235374
86AMPK signaling pathway_Homo sapiens_hsa041520.73219409
87Insulin signaling pathway_Homo sapiens_hsa049100.72129316
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71777548
89Biosynthesis of amino acids_Homo sapiens_hsa012300.71609612
90Prolactin signaling pathway_Homo sapiens_hsa049170.71345256
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69825587
92Retinol metabolism_Homo sapiens_hsa008300.69291562
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69225516
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.68483838
95Gap junction_Homo sapiens_hsa045400.68273678
96GnRH signaling pathway_Homo sapiens_hsa049120.68241329
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.68002935
98Mismatch repair_Homo sapiens_hsa034300.67062472
99Amoebiasis_Homo sapiens_hsa051460.66873082
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66830823
101beta-Alanine metabolism_Homo sapiens_hsa004100.66102218
102Chemical carcinogenesis_Homo sapiens_hsa052040.65160482
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64643351
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.64552738
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64018232
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63362954
107Melanogenesis_Homo sapiens_hsa049160.63327624
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62909423
109Fatty acid metabolism_Homo sapiens_hsa012120.61720573
110Glucagon signaling pathway_Homo sapiens_hsa049220.60256364
111Axon guidance_Homo sapiens_hsa043600.59671061
112Olfactory transduction_Homo sapiens_hsa047400.59413224
113Taste transduction_Homo sapiens_hsa047420.57144165
114Caffeine metabolism_Homo sapiens_hsa002320.57050471
115Protein export_Homo sapiens_hsa030600.56105382
116Alcoholism_Homo sapiens_hsa050340.55505671
117ErbB signaling pathway_Homo sapiens_hsa040120.55272249
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54985350
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.53071191
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51980641
121Amphetamine addiction_Homo sapiens_hsa050310.51849440
122Long-term depression_Homo sapiens_hsa047300.51439480
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51146592
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50938957
125Sulfur metabolism_Homo sapiens_hsa009200.50414166
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49499270
127Cocaine addiction_Homo sapiens_hsa050300.49253033
128Systemic lupus erythematosus_Homo sapiens_hsa053220.49039774
129Viral carcinogenesis_Homo sapiens_hsa052030.48579483
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48479190
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47968455
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47782124
133Basal transcription factors_Homo sapiens_hsa030220.47625233
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47366571
135Renin-angiotensin system_Homo sapiens_hsa046140.46630139
136Starch and sucrose metabolism_Homo sapiens_hsa005000.45618598
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44412444
138Dopaminergic synapse_Homo sapiens_hsa047280.43627032
139Butanoate metabolism_Homo sapiens_hsa006500.43234009
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43152002
141Fat digestion and absorption_Homo sapiens_hsa049750.42193158
142Prion diseases_Homo sapiens_hsa050200.41661212
143Insulin secretion_Homo sapiens_hsa049110.41476249

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