ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.49277113
2	translational termination (GO:0006415)	8.18135300
3	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.99635720
4	cotranslational protein targeting to membrane (GO:0006613)	6.91415792
5	protein targeting to ER (GO:0045047)	6.76913305
6	ribosomal small subunit assembly (GO:0000028)	6.75023595
7	translational elongation (GO:0006414)	6.65047401
8	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.46706729
9	cellular protein complex disassembly (GO:0043624)	6.42881918
10	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.19499064
11	protein localization to endoplasmic reticulum (GO:0070972)	6.19491162
12	viral life cycle (GO:0019058)	6.10518284
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.84392740
14	ribosomal large subunit biogenesis (GO:0042273)	5.39510260
15	protein complex disassembly (GO:0043241)	5.38404848
16	ribosomal small subunit biogenesis (GO:0042274)	5.35664435
17	translational initiation (GO:0006413)	5.25109556
18	maturation of SSU-rRNA (GO:0030490)	5.18547644
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.09468206
20	ATP synthesis coupled proton transport (GO:0015986)	5.09468206
21	macromolecular complex disassembly (GO:0032984)	5.06921014
22	protein targeting to membrane (GO:0006612)	4.56776106
23	neuronal stem cell maintenance (GO:0097150)	4.38445886
24	neuron fate determination (GO:0048664)	4.18765610
25	microtubule depolymerization (GO:0007019)	4.14502735
26	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.10214354
27	histone H2A acetylation (GO:0043968)	4.05716036
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.92743120
29	mRNA catabolic process (GO:0006402)	3.91593240
30	cell proliferation involved in metanephros development (GO:0072203)	3.73207149
31	sequestering of actin monomers (GO:0042989)	3.70873741
32	somite development (GO:0061053)	3.70490679
33	respiratory electron transport chain (GO:0022904)	3.63263824
34	translation (GO:0006412)	3.62434692
35	behavioral response to nicotine (GO:0035095)	3.60857990
36	otic vesicle formation (GO:0030916)	3.58223065
37	electron transport chain (GO:0022900)	3.54208587
38	RNA catabolic process (GO:0006401)	3.51707460
39	inner mitochondrial membrane organization (GO:0007007)	3.29084313
40	spliceosomal snRNP assembly (GO:0000387)	3.28567956
41	nephron tubule morphogenesis (GO:0072078)	3.23835116
42	nephron epithelium morphogenesis (GO:0072088)	3.23835116
43	transmission of nerve impulse (GO:0019226)	3.21326010
44	presynaptic membrane assembly (GO:0097105)	3.17504991
45	positive regulation of gastrulation (GO:2000543)	3.16990330
46	spermatid nucleus differentiation (GO:0007289)	3.15532858
47	protein-cofactor linkage (GO:0018065)	3.11989256
48	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.10211098
49	phosphate ion transport (GO:0006817)	3.09930803
50	chromatin remodeling at centromere (GO:0031055)	3.07482353
51	CENP-A containing nucleosome assembly (GO:0034080)	3.06040201
52	presynaptic membrane organization (GO:0097090)	3.04950448
53	forebrain neuron differentiation (GO:0021879)	3.04673073
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.03046700
55	lateral sprouting from an epithelium (GO:0060601)	3.00614358
56	radial glial cell differentiation (GO:0060019)	2.98905622
57	notochord development (GO:0030903)	2.98596495
58	nonmotile primary cilium assembly (GO:0035058)	2.95413101
59	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.90119044
60	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.90119044
61	NADH dehydrogenase complex assembly (GO:0010257)	2.90119044
62	cell proliferation in forebrain (GO:0021846)	2.89601590
63	establishment of protein localization to membrane (GO:0090150)	2.87427492
64	maternal behavior (GO:0042711)	2.87313143
65	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.84692846
66	protein complex biogenesis (GO:0070271)	2.82441661
67	urate metabolic process (GO:0046415)	2.80891544
68	tongue development (GO:0043586)	2.80842306
69	maturation of 5.8S rRNA (GO:0000460)	2.80200618
70	serine family amino acid catabolic process (GO:0009071)	2.79117628
71	centriole replication (GO:0007099)	2.78326557
72	cell proliferation involved in kidney development (GO:0072111)	2.74635430
73	establishment of protein localization to organelle (GO:0072594)	2.73869840
74	peristalsis (GO:0030432)	2.70380703
75	protein targeting (GO:0006605)	2.69635659
76	midbrain development (GO:0030901)	2.67828033
77	parental behavior (GO:0060746)	2.67650364
78	outer ear morphogenesis (GO:0042473)	2.64395340
79	microtubule polymerization or depolymerization (GO:0031109)	2.63283749
80	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.62744177
81	renal system development (GO:0072001)	2.61806028
82	spinal cord motor neuron differentiation (GO:0021522)	2.58962993
83	neuron fate specification (GO:0048665)	2.58823095
84	smoothened signaling pathway (GO:0007224)	2.58401400
85	postsynaptic membrane organization (GO:0001941)	2.55856653
86	glycine metabolic process (GO:0006544)	2.54791560
87	DNA ligation (GO:0006266)	2.53882960
88	purine nucleobase biosynthetic process (GO:0009113)	2.53875794
89	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.53239080
90	histone exchange (GO:0043486)	2.51881970
91	dopamine transport (GO:0015872)	2.49786513
92	artery development (GO:0060840)	2.49682289
93	DNA replication-independent nucleosome organization (GO:0034724)	2.48410994
94	DNA replication-independent nucleosome assembly (GO:0006336)	2.48410994
95	chaperone-mediated protein transport (GO:0072321)	2.48361657
96	kinetochore assembly (GO:0051382)	2.48153683
97	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.47874438
98	substrate-independent telencephalic tangential migration (GO:0021826)	2.47874438
99	hydrogen ion transmembrane transport (GO:1902600)	2.47689272
100	regulation of development, heterochronic (GO:0040034)	2.46983945

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	4.51289830
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.41119574
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.18862957
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.98704431
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.96864321
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.95890528
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.90024316
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.82702633
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.79012929
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.64752045
11	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.58069297
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.52118302
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.41722633
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.35783160
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.28847909
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.24670498
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.07882071
18	EWS_26573619_Chip-Seq_HEK293_Human	2.07163436
19	MYC_18940864_ChIP-ChIP_HL60_Human	2.04059684
20	VDR_22108803_ChIP-Seq_LS180_Human	2.03011321
21	FUS_26573619_Chip-Seq_HEK293_Human	2.02702312
22	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.02218733
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.96472488
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92825650
25	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.91469279
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.90156102
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89232298
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.85590639
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.84677801
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.77386888
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.77301137
32	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.69571224
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.63535295
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57580821
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55257149
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54579616
37	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.53956383
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48846506
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.43695266
40	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.41513023
41	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.40520566
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.39518203
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.38922241
44	P300_19829295_ChIP-Seq_ESCs_Human	1.37816922
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36328942
46	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.34814818
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33640645
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33191519
49	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.33180416
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32305118
51	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.30405918
52	GBX2_23144817_ChIP-Seq_PC3_Human	1.29682310
53	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.28445137
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.25526623
55	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.23389877
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.19733519
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18623051
58	E2F7_22180533_ChIP-Seq_HELA_Human	1.17102708
59	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.13972933
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.12732913
61	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.12152851
62	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.12012193
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10475156
64	AR_21909140_ChIP-Seq_LNCAP_Human	1.08675916
65	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07841446
66	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.07242561
67	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.07046998
68	TAF15_26573619_Chip-Seq_HEK293_Human	1.06787797
69	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.06523394
70	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04714993
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02772437
72	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02760773
73	XRN2_22483619_ChIP-Seq_HELA_Human	1.02219592
74	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.00723712
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98720973
76	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.98359588
77	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.98218204
78	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.97985915
79	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.97449514
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.96888539
81	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.94911247
82	RUNX2_22187159_ChIP-Seq_PCA_Human	0.93884564
83	AR_25329375_ChIP-Seq_VCAP_Human	0.93786898
84	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.92995048
85	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.92921923
86	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.92921923
87	FOXP3_21729870_ChIP-Seq_TREG_Human	0.92642683
88	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92489942
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.91885493
90	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.89888515
91	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.89422632
92	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.89109101
93	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.88424816
94	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.87001337
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.86307560
96	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.85227767
97	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85227767
98	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.84154835
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.84015014
100	SOX2_19829295_ChIP-Seq_ESCs_Human	0.84015014

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	6.97033431
2	MP0009379_abnormal_foot_pigmentation	6.35823167
3	MP0003880_abnormal_central_pattern	5.37645206
4	MP0002938_white_spotting	3.38402259
5	MP0002653_abnormal_ependyma_morphology	3.05708988
6	MP0006292_abnormal_olfactory_placode	2.59816283
7	MP0002234_abnormal_pharynx_morphology	2.37464777
8	MP0001293_anophthalmia	2.23980640
9	MP0001485_abnormal_pinna_reflex	2.18039927
10	MP0003283_abnormal_digestive_organ	2.15698540
11	MP0003878_abnormal_ear_physiology	2.11465069
12	MP0005377_hearing/vestibular/ear_phenot	2.11465069
13	MP0002928_abnormal_bile_duct	2.05392152
14	MP0004133_heterotaxia	1.96984569
15	MP0004142_abnormal_muscle_tone	1.95389380
16	MP0001529_abnormal_vocalization	1.91870281
17	MP0002102_abnormal_ear_morphology	1.84058382
18	MP0006072_abnormal_retinal_apoptosis	1.74666162
19	MP0005084_abnormal_gallbladder_morpholo	1.73239366
20	MP0008058_abnormal_DNA_repair	1.72613528
21	MP0000566_synostosis	1.69505485
22	MP0003011_delayed_dark_adaptation	1.64809410
23	MP0000631_abnormal_neuroendocrine_gland	1.56695162
24	MP0005423_abnormal_somatic_nervous	1.53105977
25	MP0005503_abnormal_tendon_morphology	1.49872089
26	MP0002277_abnormal_respiratory_mucosa	1.46164772
27	MP0000778_abnormal_nervous_system	1.45905916
28	MP0002697_abnormal_eye_size	1.43775091
29	MP0000026_abnormal_inner_ear	1.40689880
30	MP0010030_abnormal_orbit_morphology	1.39293655
31	MP0003890_abnormal_embryonic-extraembry	1.38076805
32	MP0006276_abnormal_autonomic_nervous	1.33711621
33	MP0008789_abnormal_olfactory_epithelium	1.32935166
34	MP0000049_abnormal_middle_ear	1.32777514
35	MP0010386_abnormal_urinary_bladder	1.32450194
36	MP0005551_abnormal_eye_electrophysiolog	1.31816827
37	MP0003938_abnormal_ear_development	1.29053152
38	MP0005253_abnormal_eye_physiology	1.28546021
39	MP0001286_abnormal_eye_development	1.24604388
40	MP0010094_abnormal_chromosome_stability	1.23551742
41	MP0009053_abnormal_anal_canal	1.22535773
42	MP0004885_abnormal_endolymph	1.20606361
43	MP0002249_abnormal_larynx_morphology	1.18378211
44	MP0002282_abnormal_trachea_morphology	1.13694252
45	MP0001486_abnormal_startle_reflex	1.11460068
46	MP0005391_vision/eye_phenotype	1.10630504
47	MP0004147_increased_porphyrin_level	1.09078122
48	MP0000537_abnormal_urethra_morphology	1.08393418
49	MP0009672_abnormal_birth_weight	1.06158009
50	MP0002638_abnormal_pupillary_reflex	1.05815852
51	MP0000762_abnormal_tongue_morphology	1.00567360
52	MP0005195_abnormal_posterior_eye	1.00220673
53	MP0002095_abnormal_skin_pigmentation	0.99939764
54	MP0005499_abnormal_olfactory_system	0.99252456
55	MP0005394_taste/olfaction_phenotype	0.99252456
56	MP0003119_abnormal_digestive_system	0.99179999
57	MP0002736_abnormal_nociception_after	0.96402050
58	MP0000955_abnormal_spinal_cord	0.94131055
59	MP0003252_abnormal_bile_duct	0.94111773
60	MP0005174_abnormal_tail_pigmentation	0.92541865
61	MP0001963_abnormal_hearing_physiology	0.91103289
62	MP0001984_abnormal_olfaction	0.90677579
63	MP0002837_dystrophic_cardiac_calcinosis	0.89266557
64	MP0000372_irregular_coat_pigmentation	0.89063340
65	MP0005171_absent_coat_pigmentation	0.88388715
66	MP0000428_abnormal_craniofacial_morphol	0.87108962
67	MP0003122_maternal_imprinting	0.86752550
68	MP0002751_abnormal_autonomic_nervous	0.86622943
69	MP0003718_maternal_effect	0.83812609
70	MP0001299_abnormal_eye_distance/	0.83646250
71	MP0008995_early_reproductive_senescence	0.82698674
72	MP0004742_abnormal_vestibular_system	0.79288646
73	MP0004019_abnormal_vitamin_homeostasis	0.79137961
74	MP0003755_abnormal_palate_morphology	0.77821127
75	MP0009745_abnormal_behavioral_response	0.76521473
76	MP0002233_abnormal_nose_morphology	0.76441624
77	MP0003942_abnormal_urinary_system	0.75495537
78	MP0003861_abnormal_nervous_system	0.75354892
79	MP0002111_abnormal_tail_morphology	0.75295961
80	MP0001346_abnormal_lacrimal_gland	0.74819678
81	MP0002210_abnormal_sex_determination	0.73472716
82	MP0001929_abnormal_gametogenesis	0.71984024
83	MP0002184_abnormal_innervation	0.71298488
84	MP0002557_abnormal_social/conspecific_i	0.71247262
85	MP0002092_abnormal_eye_morphology	0.70988308
86	MP0002064_seizures	0.70576206
87	MP0002735_abnormal_chemical_nociception	0.68643718
88	MP0001145_abnormal_male_reproductive	0.67556272
89	MP0002752_abnormal_somatic_nervous	0.67287126
90	MP0000653_abnormal_sex_gland	0.66365484
91	MP0005187_abnormal_penis_morphology	0.66310091
92	MP0002272_abnormal_nervous_system	0.66223465
93	MP0003937_abnormal_limbs/digits/tail_de	0.64989062
94	MP0000534_abnormal_ureter_morphology	0.64893590
95	MP0002160_abnormal_reproductive_system	0.63409837
96	MP0003698_abnormal_male_reproductive	0.63155852
97	MP0002734_abnormal_mechanical_nocicepti	0.62885338
98	MP0009046_muscle_twitch	0.61368090
99	MP0009250_abnormal_appendicular_skeleto	0.60269379
100	MP0004957_abnormal_blastocyst_morpholog	0.60140062

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Generalized aminoaciduria (HP:0002909)	4.42367753
2	Abnormal number of erythroid precursors (HP:0012131)	4.40232892
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.38265603
4	True hermaphroditism (HP:0010459)	4.17975944
5	Reticulocytopenia (HP:0001896)	3.95046523
6	Bilateral microphthalmos (HP:0007633)	3.84888011
7	Abnormal number of incisors (HP:0011064)	3.78851558
8	Macrocytic anemia (HP:0001972)	3.74404079
9	Pancreatic cysts (HP:0001737)	3.60683718
10	Pancreatic fibrosis (HP:0100732)	3.47213997
11	Acute necrotizing encephalopathy (HP:0006965)	3.46426324
12	Septo-optic dysplasia (HP:0100842)	3.38414701
13	Abnormality of the parietal bone (HP:0002696)	3.34147765
14	Increased hepatocellular lipid droplets (HP:0006565)	3.15451009
15	Median cleft lip (HP:0000161)	3.14645842
16	Mitochondrial inheritance (HP:0001427)	3.07369714
17	Abnormality of the diencephalon (HP:0010662)	3.02230443
18	Hypoplastic pelvis (HP:0008839)	2.98426048
19	Progressive macrocephaly (HP:0004481)	2.82727061
20	Maternal diabetes (HP:0009800)	2.81574940
21	Acute encephalopathy (HP:0006846)	2.76455071
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.74966047
23	Lipid accumulation in hepatocytes (HP:0006561)	2.70679273
24	Sclerocornea (HP:0000647)	2.70244840
25	Partial duplication of the phalanx of hand (HP:0009999)	2.68407112
26	Supernumerary ribs (HP:0005815)	2.65720035
27	Cystic liver disease (HP:0006706)	2.65204445
28	Down-sloping shoulders (HP:0200021)	2.62386048
29	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.62234169
30	Short 4th metacarpal (HP:0010044)	2.62234169
31	Depressed nasal tip (HP:0000437)	2.61333978
32	Partial duplication of thumb phalanx (HP:0009944)	2.59232442
33	Colon cancer (HP:0003003)	2.58882852
34	Congenital stationary night blindness (HP:0007642)	2.58181300
35	Congenital, generalized hypertrichosis (HP:0004540)	2.57307221
36	Supernumerary bones of the axial skeleton (HP:0009144)	2.55011422
37	Myokymia (HP:0002411)	2.52399999
38	Pendular nystagmus (HP:0012043)	2.52299073
39	Glycosuria (HP:0003076)	2.49714047
40	Abnormality of urine glucose concentration (HP:0011016)	2.49714047
41	Abnormality of midbrain morphology (HP:0002418)	2.49415626
42	Molar tooth sign on MRI (HP:0002419)	2.49415626
43	Oligodactyly (hands) (HP:0001180)	2.49188148
44	Renal Fanconi syndrome (HP:0001994)	2.47797815
45	Anophthalmia (HP:0000528)	2.47621221
46	Hemivertebrae (HP:0002937)	2.47508321
47	Absent septum pellucidum (HP:0001331)	2.47040750
48	Optic nerve hypoplasia (HP:0000609)	2.44597281
49	Anencephaly (HP:0002323)	2.42080528
50	Abnormal ciliary motility (HP:0012262)	2.37912596
51	Increased CSF lactate (HP:0002490)	2.37902944
52	Pallor (HP:0000980)	2.37245613
53	Hepatocellular necrosis (HP:0001404)	2.37139479
54	Abnormality of the labia minora (HP:0012880)	2.34322317
55	Hepatic necrosis (HP:0002605)	2.34025444
56	Medial flaring of the eyebrow (HP:0010747)	2.31881445
57	Esophageal atresia (HP:0002032)	2.27384120
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26162694
59	Exertional dyspnea (HP:0002875)	2.23270260
60	Hyperphosphaturia (HP:0003109)	2.20266731
61	Gastrointestinal atresia (HP:0002589)	2.17543405
62	Rib fusion (HP:0000902)	2.16428913
63	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.14459526
64	Gait imbalance (HP:0002141)	2.12649196
65	Oligodactyly (HP:0012165)	2.12561749
66	Congenital primary aphakia (HP:0007707)	2.12477871
67	Neoplasm of the heart (HP:0100544)	2.10714040
68	Respiratory difficulties (HP:0002880)	2.09815804
69	Cerebral edema (HP:0002181)	2.09010194
70	Preaxial hand polydactyly (HP:0001177)	2.08540281
71	Depressed nasal ridge (HP:0000457)	2.08434202
72	Split foot (HP:0001839)	2.07803501
73	Abnormality of the 4th metacarpal (HP:0010012)	2.07533414
74	Abnormal respiratory motile cilium physiology (HP:0012261)	2.07289263
75	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.03698578
76	Abnormality of the nasal septum (HP:0000419)	2.03543860
77	Nephrogenic diabetes insipidus (HP:0009806)	2.02607597
78	Rhinitis (HP:0012384)	2.02542864
79	Holoprosencephaly (HP:0001360)	2.00174433
80	Postaxial hand polydactyly (HP:0001162)	2.00071335
81	Optic disc pallor (HP:0000543)	1.98327949
82	Postaxial foot polydactyly (HP:0001830)	1.95133637
83	Abnormality of renal resorption (HP:0011038)	1.94999849
84	Rectal fistula (HP:0100590)	1.94549367
85	Rectovaginal fistula (HP:0000143)	1.94549367
86	Midline defect of the nose (HP:0004122)	1.93934528
87	Synostosis involving the elbow (HP:0003938)	1.87488721
88	Humeroradial synostosis (HP:0003041)	1.87488721
89	Male pseudohermaphroditism (HP:0000037)	1.87171950
90	Occipital encephalocele (HP:0002085)	1.86693959
91	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.86551319
92	Renal cortical cysts (HP:0000803)	1.86371955
93	Abnormality of the incisor (HP:0000676)	1.86238307
94	Medulloblastoma (HP:0002885)	1.85982360
95	Vertebral fusion (HP:0002948)	1.83730154
96	Nephronophthisis (HP:0000090)	1.82288893
97	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.79317985
98	Genital tract atresia (HP:0001827)	1.77693052
99	Morphological abnormality of the inner ear (HP:0011390)	1.76909201
100	Triphalangeal thumb (HP:0001199)	1.75917342

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.29136288
2	BUB1	4.78269450
3	MAPK15	3.94568534
4	VRK1	3.30797895
5	PNCK	3.24438771
6	EPHB2	2.84374449
7	TSSK6	2.82534247
8	TNIK	2.39124897
9	CDC7	2.32487266
10	DYRK2	2.30213020
11	EPHA4	2.29302615
12	CDK19	2.25900520
13	NUAK1	2.25587128
14	PASK	2.18774478
15	BRSK2	2.09709324
16	WEE1	2.08453831
17	ZAK	2.08216038
18	TAF1	1.85739113
19	DYRK3	1.84213323
20	PLK3	1.83148269
21	NME1	1.66997369
22	WNK3	1.50297433
23	TGFBR1	1.49027308
24	INSRR	1.46673932
25	PLK4	1.41248495
26	ADRBK2	1.31403122
27	BMPR1B	1.30816810
28	CASK	1.28563536
29	FRK	1.22331237
30	MAPKAPK5	1.19001248
31	MAP3K10	1.13957640
32	CHEK2	1.07652082
33	FGFR2	1.03997568
34	TLK1	1.03175611
35	RPS6KA4	1.01542980
36	DYRK1B	0.99539055
37	MKNK1	0.96867852
38	ACVR1B	0.94577379
39	PRKCG	0.93391066
40	NLK	0.89624119
41	GRK1	0.89584710
42	CDK3	0.85354294
43	BRSK1	0.83525382
44	AURKA	0.83299814
45	LATS1	0.83257210
46	UHMK1	0.83031460
47	TTK	0.81050308
48	NEK2	0.78131679
49	LRRK2	0.75411937
50	MKNK2	0.72121341
51	DYRK1A	0.71474845
52	IRAK1	0.71158435
53	PKN1	0.70829593
54	TYRO3	0.70812006
55	ADRBK1	0.68771989
56	AURKB	0.68669946
57	NTRK2	0.65886150
58	PLK1	0.64520148
59	GRK7	0.63788396
60	CDK8	0.60593451
61	RPS6KA5	0.57812945
62	TXK	0.55674271
63	MAPK13	0.54704615
64	CCNB1	0.53320845
65	EIF2AK2	0.51613334
66	BCKDK	0.48327435
67	DAPK3	0.46153658
68	SRPK1	0.44070025
69	STK16	0.43818291
70	CSNK2A1	0.43425125
71	WNK4	0.42345708
72	EPHA3	0.41399522
73	MAPK7	0.39810836
74	CSNK2A2	0.38684512
75	RPS6KB2	0.38272997
76	PRKACB	0.38082974
77	OBSCN	0.37935662
78	GRK5	0.35219279
79	ATR	0.33363992
80	STK3	0.30794654
81	PRKACA	0.30671642
82	DDR2	0.28204049
83	PRKCE	0.28055056
84	SGK223	0.27975003
85	SGK494	0.27975003
86	ERBB2	0.25864758
87	BCR	0.25806526
88	CSNK1A1	0.22938687
89	MARK1	0.22649640
90	ATM	0.21991875
91	MELK	0.18901750
92	SGK2	0.18642920
93	CSNK1E	0.18119072
94	CHEK1	0.17807620
95	SGK1	0.17585148
96	FGFR1	0.17278522
97	PRKG1	0.17001372
98	CAMK1	0.16901760
99	PLK2	0.16838721
100	YES1	0.16136530

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.57719849
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.11683634
3	Parkinsons disease_Homo sapiens_hsa05012	3.51791739
4	Mismatch repair_Homo sapiens_hsa03430	2.72191365
5	Homologous recombination_Homo sapiens_hsa03440	2.59620984
6	Huntingtons disease_Homo sapiens_hsa05016	2.53871401
7	Basal cell carcinoma_Homo sapiens_hsa05217	2.32144274
8	Alzheimers disease_Homo sapiens_hsa05010	2.31968382
9	Proteasome_Homo sapiens_hsa03050	2.20489875
10	RNA polymerase_Homo sapiens_hsa03020	2.19509778
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.13420539
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.10174965
13	DNA replication_Homo sapiens_hsa03030	2.03636139
14	Protein export_Homo sapiens_hsa03060	1.87593119
15	One carbon pool by folate_Homo sapiens_hsa00670	1.79134553
16	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.66102723
17	Phototransduction_Homo sapiens_hsa04744	1.65576734
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65301095
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.62161498
20	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.57955217
21	Nicotine addiction_Homo sapiens_hsa05033	1.53678451
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.53207652
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.49413074
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.45018921
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.44465663
26	Renin-angiotensin system_Homo sapiens_hsa04614	1.39664771
27	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.27178543
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.23289358
29	Spliceosome_Homo sapiens_hsa03040	1.19576192
30	Base excision repair_Homo sapiens_hsa03410	1.16742182
31	Taste transduction_Homo sapiens_hsa04742	1.15117648
32	Butanoate metabolism_Homo sapiens_hsa00650	1.13315616
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.07480729
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05654343
35	Folate biosynthesis_Homo sapiens_hsa00790	1.05201519
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.03880396
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00009131
38	Retinol metabolism_Homo sapiens_hsa00830	0.99864303
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95824868
40	Caffeine metabolism_Homo sapiens_hsa00232	0.95204614
41	RNA degradation_Homo sapiens_hsa03018	0.92870898
42	Propanoate metabolism_Homo sapiens_hsa00640	0.92788230
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92442898
44	Purine metabolism_Homo sapiens_hsa00230	0.92431860
45	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.86267620
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.79506937
47	Basal transcription factors_Homo sapiens_hsa03022	0.79129918
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78339413
49	Cocaine addiction_Homo sapiens_hsa05030	0.74001062
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73221458
51	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.73097862
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.72632674
53	RNA transport_Homo sapiens_hsa03013	0.72400007
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71159384
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70326643
56	Morphine addiction_Homo sapiens_hsa05032	0.68200912
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67720648
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66558660
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.65389251
60	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.64034061
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62015508
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59563495
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57350454
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56939306
65	GABAergic synapse_Homo sapiens_hsa04727	0.56751603
66	Cell cycle_Homo sapiens_hsa04110	0.56027625
67	Hippo signaling pathway_Homo sapiens_hsa04390	0.55305410
68	Metabolic pathways_Homo sapiens_hsa01100	0.54286424
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53599860
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51574223
71	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.49573950
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.47001715
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46266415
74	Serotonergic synapse_Homo sapiens_hsa04726	0.46201554
75	Olfactory transduction_Homo sapiens_hsa04740	0.46185165
76	Alcoholism_Homo sapiens_hsa05034	0.45947765
77	Circadian entrainment_Homo sapiens_hsa04713	0.45669932
78	Peroxisome_Homo sapiens_hsa04146	0.43911311
79	Glutathione metabolism_Homo sapiens_hsa00480	0.43469340
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.42451536
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.40661170
82	Sulfur relay system_Homo sapiens_hsa04122	0.40145440
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39942251
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37430687
85	Mineral absorption_Homo sapiens_hsa04978	0.35725282
86	Fatty acid degradation_Homo sapiens_hsa00071	0.35560390
87	Amphetamine addiction_Homo sapiens_hsa05031	0.33681638
88	Histidine metabolism_Homo sapiens_hsa00340	0.33449807
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33404005
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.33052117
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.31548611
92	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.30821593
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.30198743
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.30097566
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30070613
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.27345668
97	p53 signaling pathway_Homo sapiens_hsa04115	0.27092865
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.26159050
99	Protein digestion and absorption_Homo sapiens_hsa04974	0.22370086
100	Melanogenesis_Homo sapiens_hsa04916	0.21722582

GLDCP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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