GLDN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)9.30002785
2lateral sprouting from an epithelium (GO:0060601)8.75013343
3mesenchymal-epithelial cell signaling (GO:0060638)8.59167705
4prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060527.72664140
5regulation of branching involved in salivary gland morphogenesis (GO:0060693)7.53025609
6central nervous system myelination (GO:0022010)7.35769318
7axon ensheathment in central nervous system (GO:0032291)7.35769318
8bone trabecula formation (GO:0060346)6.15039188
9branching involved in labyrinthine layer morphogenesis (GO:0060670)5.89414703
10craniofacial suture morphogenesis (GO:0097094)5.85465288
11radial glial cell differentiation (GO:0060019)5.63660671
12cell proliferation involved in kidney development (GO:0072111)5.50888319
13positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)5.43653708
14branching involved in prostate gland morphogenesis (GO:0060442)5.43062912
15artery smooth muscle contraction (GO:0014824)5.41432514
16keratinocyte proliferation (GO:0043616)5.33276302
17negative regulation of osteoblast proliferation (GO:0033689)5.31101595
18cell proliferation involved in metanephros development (GO:0072203)5.26633208
19branching involved in salivary gland morphogenesis (GO:0060445)5.12396083
20mesenchymal cell proliferation (GO:0010463)5.07454655
21synaptic vesicle maturation (GO:0016188)4.97933643
22regulation of non-canonical Wnt signaling pathway (GO:2000050)4.87440461
23otic vesicle formation (GO:0030916)4.73720879
24tonic smooth muscle contraction (GO:0014820)4.72698627
25branch elongation of an epithelium (GO:0060602)4.61120276
26negative regulation of JUN kinase activity (GO:0043508)4.59125969
27synaptic vesicle docking involved in exocytosis (GO:0016081)4.57077534
28cranial suture morphogenesis (GO:0060363)4.54036208
29regulation of pigment cell differentiation (GO:0050932)4.49811148
30limb bud formation (GO:0060174)4.49758483
31cellular response to vitamin D (GO:0071305)4.40034371
32somite development (GO:0061053)4.37700462
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.36597620
34glutamate secretion (GO:0014047)4.31771227
35L-amino acid import (GO:0043092)4.25370163
36prostate gland epithelium morphogenesis (GO:0060740)4.17960434
37regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.17503963
38cellular potassium ion homeostasis (GO:0030007)4.15607813
39response to follicle-stimulating hormone (GO:0032354)4.11954791
40cellular response to cholesterol (GO:0071397)4.05033071
41renal system development (GO:0072001)4.03694788
42axis elongation (GO:0003401)4.03545194
43organ growth (GO:0035265)4.02388711
44planar cell polarity pathway involved in neural tube closure (GO:0090179)4.01837455
45sequestering of extracellular ligand from receptor (GO:0035581)4.01799144
46estrogen biosynthetic process (GO:0006703)3.94486153
47synaptic vesicle exocytosis (GO:0016079)3.94126161
48hair follicle morphogenesis (GO:0031069)3.91186212
49activation of protein kinase A activity (GO:0034199)3.85199122
50glucocorticoid biosynthetic process (GO:0006704)3.83651672
51cellular response to prostaglandin stimulus (GO:0071379)3.83626738
52vascular smooth muscle contraction (GO:0014829)3.83530823
53neuronal action potential propagation (GO:0019227)3.83363410
54regulation of keratinocyte proliferation (GO:0010837)3.83216400
55negative regulation of fibroblast apoptotic process (GO:2000270)3.81774336
56peripheral nervous system axon ensheathment (GO:0032292)3.80846834
57myelination in peripheral nervous system (GO:0022011)3.80846834
58cell differentiation involved in kidney development (GO:0061005)3.78034581
59regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.75979591
60regulation of morphogenesis of a branching structure (GO:0060688)3.68315164
61regulation of developmental pigmentation (GO:0048070)3.65652586
62regulation of systemic arterial blood pressure by hormone (GO:0001990)3.64133306
63regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.64133306
64endocrine process (GO:0050886)3.64133306
65sodium ion export (GO:0071436)3.63551845
66vocalization behavior (GO:0071625)3.57816744
67pharyngeal system development (GO:0060037)3.56020001
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.54598066
69regulation of short-term neuronal synaptic plasticity (GO:0048172)3.54273719
70presynaptic membrane organization (GO:0097090)3.51854308
71dermatan sulfate biosynthetic process (GO:0030208)3.50703020
72mesenchymal cell differentiation (GO:0048762)3.50388983
73digestive tract morphogenesis (GO:0048546)3.48597706
74regulation of osteoblast proliferation (GO:0033688)3.47392697
75organ induction (GO:0001759)3.47286665
76mesonephros development (GO:0001823)3.46014420
77neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.42402645
78long-chain fatty acid biosynthetic process (GO:0042759)3.41529731
79amino acid import (GO:0043090)3.41250803
80inner ear receptor cell differentiation (GO:0060113)3.40969014
81adenosine receptor signaling pathway (GO:0001973)3.37198344
82positive regulation of cholesterol efflux (GO:0010875)3.36810088
83positive regulation of developmental pigmentation (GO:0048087)3.36707939
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.36245560
85inositol phosphate-mediated signaling (GO:0048016)3.35863098
86cytoskeletal anchoring at plasma membrane (GO:0007016)3.33209727
87regulation of smoothened signaling pathway (GO:0008589)3.32940601
88gamma-aminobutyric acid transport (GO:0015812)3.30983758
89protein localization to cell surface (GO:0034394)3.30251761
90regulation of synaptic vesicle exocytosis (GO:2000300)3.29615480
91convergent extension (GO:0060026)3.29242276
92regulation of chemokine-mediated signaling pathway (GO:0070099)3.28792155
93cellular response to cadmium ion (GO:0071276)3.28246678
94sodium-independent organic anion transport (GO:0043252)3.27873136
95* neuronal ion channel clustering (GO:0045161)3.27488788
96negative regulation of fatty acid transport (GO:2000192)3.27233008
97gamma-aminobutyric acid signaling pathway (GO:0007214)3.27197165
98hindlimb morphogenesis (GO:0035137)3.27141816
99mammary gland epithelial cell differentiation (GO:0060644)3.24537113
100negative regulation of smoothened signaling pathway (GO:0045879)3.24098141
101glucocorticoid metabolic process (GO:0008211)3.23646712
102cellular response to sterol (GO:0036315)3.22198086
103regulation of synaptic vesicle transport (GO:1902803)3.21881139
104regulation of neuronal synaptic plasticity (GO:0048168)3.19536612
105cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18885926
106dorsal/ventral axis specification (GO:0009950)3.18660916
107glial cell migration (GO:0008347)3.18610354
108phasic smooth muscle contraction (GO:0014821)3.17942960
109dermatan sulfate metabolic process (GO:0030205)3.16429189
110negative regulation of gluconeogenesis (GO:0045721)3.14723861
111ionotropic glutamate receptor signaling pathway (GO:0035235)3.14614442
112potassium ion homeostasis (GO:0055075)3.13254189
113myelin maintenance (GO:0043217)3.12971783
114NLS-bearing protein import into nucleus (GO:0006607)3.10931658
115response to prostaglandin E (GO:0034695)3.10512205
116astrocyte development (GO:0014002)3.09936749
117endothelial cell differentiation (GO:0045446)3.07966979
118positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.07288896
119positive regulation of dendritic spine development (GO:0060999)3.06390981
120potassium ion import (GO:0010107)3.06126178
121proximal/distal pattern formation (GO:0009954)3.02522087
122neurotransmitter secretion (GO:0007269)2.99472838
123negative regulation of stem cell proliferation (GO:2000647)2.99456851
124myelination (GO:0042552)2.99338564
125kidney morphogenesis (GO:0060993)2.98130170
126regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.96827698
127positive regulation of membrane potential (GO:0045838)2.96623179
128ensheathment of neurons (GO:0007272)2.96606070
129axon ensheathment (GO:0008366)2.96606070
130locomotory exploration behavior (GO:0035641)2.95531321
131regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.95193329
132cerebellar Purkinje cell differentiation (GO:0021702)2.94654775
133mesodermal cell differentiation (GO:0048333)2.94440608
134negative regulation of multicellular organism growth (GO:0040015)2.94425488
135negative regulation of catenin import into nucleus (GO:0035414)2.93532318
136cellular response to vitamin (GO:0071295)2.93171671
137epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.92278041
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91079854
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87967020
140cell communication by electrical coupling (GO:0010644)2.87276983
141positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.85991991
142negative regulation of inclusion body assembly (GO:0090084)2.84415723
143neurotransmitter uptake (GO:0001504)2.83426787
144regulation of cell communication by electrical coupling (GO:0010649)2.82913066
145regulation of dendritic spine development (GO:0060998)2.82625482
146ureteric bud development (GO:0001657)2.81613267
147cellular sodium ion homeostasis (GO:0006883)2.80877855
148positive regulation of sterol transport (GO:0032373)2.80664504
149positive regulation of cholesterol transport (GO:0032376)2.80664504
150regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.80213053
151synaptic transmission, glutamatergic (GO:0035249)2.80018377
152positive regulation of fat cell differentiation (GO:0045600)2.79302770
153negative regulation of dendrite morphogenesis (GO:0050774)2.79178895
154regulation of glutamate receptor signaling pathway (GO:1900449)2.78040208
155neurotransmitter transport (GO:0006836)2.77998336
156androgen biosynthetic process (GO:0006702)2.77347706
157dendritic spine morphogenesis (GO:0060997)2.77022665
158cAMP biosynthetic process (GO:0006171)2.76878885
159cerebellar granule cell differentiation (GO:0021707)2.75154183
160neuron-neuron synaptic transmission (GO:0007270)2.74943554
161Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.74463239
162morphogenesis of an epithelial fold (GO:0060571)2.72979972
163peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.72757308
164embryonic hindlimb morphogenesis (GO:0035116)2.72731397
165regulation of systemic arterial blood pressure (GO:0003073)2.71705028
166glutamate receptor signaling pathway (GO:0007215)2.71598792
167embryonic digestive tract morphogenesis (GO:0048557)2.70752278
168neuromuscular process controlling posture (GO:0050884)2.67757932
169developmental induction (GO:0031128)2.67701024
170mechanoreceptor differentiation (GO:0042490)2.67246121
171detection of calcium ion (GO:0005513)2.64783067
172protein localization to synapse (GO:0035418)2.61348354
173regulation of excitatory postsynaptic membrane potential (GO:0060079)2.59841577
174neuron cell-cell adhesion (GO:0007158)2.58819878
175regulation of long-term neuronal synaptic plasticity (GO:0048169)2.58541726
176neuromuscular process controlling balance (GO:0050885)2.55976653
177negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.53764616
178presynaptic membrane assembly (GO:0097105)2.53564644
179transmission of nerve impulse (GO:0019226)2.53286120
180long-term memory (GO:0007616)2.52013399
181regulation of neurotransmitter secretion (GO:0046928)2.52009085
182regulation of voltage-gated calcium channel activity (GO:1901385)2.51613733
183positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.50856150
184regulation of synaptic plasticity (GO:0048167)2.49399936
185cellular response to epinephrine stimulus (GO:0071872)2.49141629
186regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.48179502
187response to dietary excess (GO:0002021)2.47076513
188regulation of neurotransmitter transport (GO:0051588)2.46599582
189exploration behavior (GO:0035640)2.46525912
190dendritic spine organization (GO:0097061)2.46427548
191chemosensory behavior (GO:0007635)2.46195337
192regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.46164954
193neurotransmitter-gated ion channel clustering (GO:0072578)2.45700701
194prostate gland growth (GO:0060736)2.45569284
195membrane depolarization during action potential (GO:0086010)2.45085331
196acidic amino acid transport (GO:0015800)2.44354614
197adult walking behavior (GO:0007628)2.44066137
198positive regulation of muscle hypertrophy (GO:0014742)2.43639975
199positive regulation of cardiac muscle hypertrophy (GO:0010613)2.43639975
200long-term synaptic potentiation (GO:0060291)2.43322980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.67943962
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.12073447
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.05451107
4GBX2_23144817_ChIP-Seq_PC3_Human2.89438283
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.53378465
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52060468
7EZH2_22144423_ChIP-Seq_EOC_Human2.51769236
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39281717
9AR_21572438_ChIP-Seq_LNCaP_Human2.34117814
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.24702081
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16246172
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15114579
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.14396846
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.14396846
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13641547
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11327276
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08740404
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07627991
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99673309
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97584680
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95915351
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94959549
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.89656831
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.89443354
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88060610
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.84594417
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79876274
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78210303
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75716770
30TP53_18474530_ChIP-ChIP_U2OS_Human1.72718141
31* P300_19829295_ChIP-Seq_ESCs_Human1.72173101
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71326921
33SMAD4_21799915_ChIP-Seq_A2780_Human1.69653518
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.69416685
35* REST_21632747_ChIP-Seq_MESCs_Mouse1.69303892
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67199170
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66009485
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63106836
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.62584793
40* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61165550
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.58411019
42* AHR_22903824_ChIP-Seq_MCF-7_Human1.58347771
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.54841091
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53342832
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53342832
46DROSHA_22980978_ChIP-Seq_HELA_Human1.52295624
47* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50978924
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49870939
49FUS_26573619_Chip-Seq_HEK293_Human1.49385651
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48896559
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48896559
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48896559
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48218154
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47637242
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45417314
56TAF15_26573619_Chip-Seq_HEK293_Human1.45414309
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45410090
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42765114
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41829012
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.40936363
61* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40393740
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.40253356
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38805672
64VDR_22108803_ChIP-Seq_LS180_Human1.36963641
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36412365
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35773715
67* ARNT_22903824_ChIP-Seq_MCF-7_Human1.35709076
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35430450
69TP53_16413492_ChIP-PET_HCT116_Human1.34961004
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.33918871
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.32273729
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31618422
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.31493402
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30071857
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28874104
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27437176
77* ER_23166858_ChIP-Seq_MCF-7_Human1.25684143
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20876742
79RXR_22108803_ChIP-Seq_LS180_Human1.20424600
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20104419
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20104419
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19318629
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.19047774
84TCF4_23295773_ChIP-Seq_U87_Human1.18814219
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.17013974
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16391485
87* STAT3_23295773_ChIP-Seq_U87_Human1.16296069
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16012576
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15627427
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15330516
91BCAT_22108803_ChIP-Seq_LS180_Human1.15127575
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14148214
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14061269
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12944493
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12362657
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.11424694
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.11119815
98TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10855230
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10846694
100TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10366087
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10288319
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.09774942
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09762834
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.09741002
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09396794
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.08781058
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08545373
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08346582
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08027624
110AR_19668381_ChIP-Seq_PC3_Human1.07589455
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.07078779
112AR_25329375_ChIP-Seq_VCAP_Human1.06875867
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.06479885
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06402932
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05949937
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.05573328
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04775270
118* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04534818
119RUNX2_22187159_ChIP-Seq_PCA_Human1.04362467
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02985405
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02687892
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01121465
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.01120987
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00753382
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00023094
126SALL1_21062744_ChIP-ChIP_HESCs_Human0.99737142
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99195558
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98880284
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.98373700
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.97715173
131EGR1_19032775_ChIP-ChIP_M12_Human0.97564579
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.96583438
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96285069
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.96168512
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.93467033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002938_white_spotting4.52833332
2MP0005187_abnormal_penis_morphology4.28162457
3MP0003690_abnormal_glial_cell4.06773202
4MP0004859_abnormal_synaptic_plasticity4.03732722
5MP0003880_abnormal_central_pattern3.84788818
6MP0004272_abnormal_basement_membrane3.71461949
7MP0005503_abnormal_tendon_morphology3.61148906
8MP0001299_abnormal_eye_distance/3.48752331
9MP0004270_analgesia3.48243676
10MP0000566_synostosis3.39055472
11MP0005248_abnormal_Harderian_gland3.34764052
12MP0005423_abnormal_somatic_nervous3.18702432
13MP0001984_abnormal_olfaction3.14975307
14MP0002064_seizures3.06161430
15MP0001661_extended_life_span3.03059677
16MP0003635_abnormal_synaptic_transmissio2.97341197
17MP0010030_abnormal_orbit_morphology2.96279338
18MP0009250_abnormal_appendicular_skeleto2.84588810
19MP0009745_abnormal_behavioral_response2.63852599
20MP0001501_abnormal_sleep_pattern2.59084392
21MP0003329_amyloid_beta_deposits2.57287673
22MP0009046_muscle_twitch2.50329487
23MP0005394_taste/olfaction_phenotype2.47781055
24MP0005499_abnormal_olfactory_system2.47781055
25MP0003136_yellow_coat_color2.46644305
26MP0002063_abnormal_learning/memory/cond2.44954295
27MP0008789_abnormal_olfactory_epithelium2.44390433
28MP0008004_abnormal_stomach_pH2.32964712
29MP0004134_abnormal_chest_morphology2.32568595
30MP0002734_abnormal_mechanical_nocicepti2.14782781
31MP0005257_abnormal_intraocular_pressure2.13580353
32MP0002572_abnormal_emotion/affect_behav2.09294627
33MP0000428_abnormal_craniofacial_morphol2.07680911
34MP0008569_lethality_at_weaning2.07166204
35MP0003011_delayed_dark_adaptation2.04906275
36MP0001293_anophthalmia2.02968902
37MP0001968_abnormal_touch/_nociception2.00694274
38MP0003942_abnormal_urinary_system1.99859819
39MP0005167_abnormal_blood-brain_barrier1.98572340
40MP0001502_abnormal_circadian_rhythm1.98077647
41MP0000647_abnormal_sebaceous_gland1.93795582
42MP0000579_abnormal_nail_morphology1.92325221
43MP0001346_abnormal_lacrimal_gland1.91238108
44MP0003879_abnormal_hair_cell1.87350211
45MP0005075_abnormal_melanosome_morpholog1.87102532
46MP0003633_abnormal_nervous_system1.79132576
47MP0001440_abnormal_grooming_behavior1.77744334
48MP0002735_abnormal_chemical_nociception1.76054541
49MP0003937_abnormal_limbs/digits/tail_de1.73963816
50MP0002282_abnormal_trachea_morphology1.73656027
51MP0002108_abnormal_muscle_morphology1.73113800
52MP0000537_abnormal_urethra_morphology1.68725977
53MP0001970_abnormal_pain_threshold1.66450507
54MP0005646_abnormal_pituitary_gland1.66077136
55MP0004130_abnormal_muscle_cell1.64766696
56MP0009053_abnormal_anal_canal1.61167014
57MP0003938_abnormal_ear_development1.59988084
58MP0005551_abnormal_eye_electrophysiolog1.59397276
59MP0000762_abnormal_tongue_morphology1.57206289
60MP0000462_abnormal_digestive_system1.56008319
61MP0009780_abnormal_chondrocyte_physiolo1.55579983
62MP0003950_abnormal_plasma_membrane1.55507087
63MP0000920_abnormal_myelination1.55328054
64MP0005670_abnormal_white_adipose1.53495787
65MP0003631_nervous_system_phenotype1.52510318
66MP0000604_amyloidosis1.49975971
67MP0004924_abnormal_behavior1.46263899
68MP0005386_behavior/neurological_phenoty1.46263899
69MP0005171_absent_coat_pigmentation1.46041585
70MP0002177_abnormal_outer_ear1.44496092
71MP0005409_darkened_coat_color1.43944223
72MP0001177_atelectasis1.43726563
73MP0003634_abnormal_glial_cell1.43687933
74MP0000427_abnormal_hair_cycle1.42857942
75MP0002229_neurodegeneration1.42699535
76MP0003878_abnormal_ear_physiology1.42461762
77MP0005377_hearing/vestibular/ear_phenot1.42461762
78MP0002295_abnormal_pulmonary_circulatio1.42262318
79MP0002098_abnormal_vibrissa_morphology1.41291542
80MP0002102_abnormal_ear_morphology1.39913591
81MP0002067_abnormal_sensory_capabilities1.38127427
82MP0000534_abnormal_ureter_morphology1.36735819
83MP0003385_abnormal_body_wall1.36466105
84MP0002009_preneoplasia1.35941922
85MP0003755_abnormal_palate_morphology1.35119144
86MP0002116_abnormal_craniofacial_bone1.33536794
87MP0002233_abnormal_nose_morphology1.30600068
88MP0008438_abnormal_cutaneous_collagen1.28400363
89MP0000751_myopathy1.28355804
90MP0001986_abnormal_taste_sensitivity1.27785637
91MP0002733_abnormal_thermal_nociception1.27551064
92MP0005508_abnormal_skeleton_morphology1.26407600
93MP0000049_abnormal_middle_ear1.26296473
94MP0004381_abnormal_hair_follicle1.25576663
95MP0010329_abnormal_lipoprotein_level1.25220497
96MP0002909_abnormal_adrenal_gland1.18976619
97MP0002736_abnormal_nociception_after1.17018550
98MP0002066_abnormal_motor_capabilities/c1.16809800
99MP0002876_abnormal_thyroid_physiology1.15444331
100MP0003195_calcinosis1.14897099
101MP0000516_abnormal_urinary_system1.14109540
102MP0005367_renal/urinary_system_phenotyp1.14109540
103MP0003935_abnormal_craniofacial_develop1.14035578
104MP0005595_abnormal_vascular_smooth1.13141643
105MP0004885_abnormal_endolymph1.12565410
106MP0001905_abnormal_dopamine_level1.11251496
107MP0000383_abnormal_hair_follicle1.10174303
108MP0002971_abnormal_brown_adipose1.08578054
109* MP0002882_abnormal_neuron_morphology1.05763028
110MP0001340_abnormal_eyelid_morphology1.04474829
111MP0001485_abnormal_pinna_reflex1.04101754
112MP0002109_abnormal_limb_morphology1.02772314
113MP0004811_abnormal_neuron_physiology1.01008035
114MP0005647_abnormal_sex_gland1.00569690
115MP0004215_abnormal_myocardial_fiber0.98699292
116MP0005220_abnormal_exocrine_pancreas0.98282473
117MP0006276_abnormal_autonomic_nervous0.98093304
118MP0002132_abnormal_respiratory_system0.97192421
119MP0008961_abnormal_basal_metabolism0.97123568
120MP0000639_abnormal_adrenal_gland0.95327781
121MP0001963_abnormal_hearing_physiology0.95233690
122MP0002638_abnormal_pupillary_reflex0.94597222
123MP0001958_emphysema0.93074754
124MP0008775_abnormal_heart_ventricle0.92274074
125MP0002932_abnormal_joint_morphology0.92257053
126MP0002277_abnormal_respiratory_mucosa0.92169308
127MP0000163_abnormal_cartilage_morphology0.91223152
128MP0003724_increased_susceptibility_to0.90946701
129MP0002168_other_aberrant_phenotype0.89953966
130MP0003632_abnormal_nervous_system0.89331361
131MP0000432_abnormal_head_morphology0.89309937
132MP0005666_abnormal_adipose_tissue0.89023590
133MP0005334_abnormal_fat_pad0.88833889
134MP0000613_abnormal_salivary_gland0.88186760
135MP0002751_abnormal_autonomic_nervous0.86771849
136MP0000372_irregular_coat_pigmentation0.86655828
137MP0002115_abnormal_skeleton_extremities0.86504943
138MP0005375_adipose_tissue_phenotype0.85659809
139MP0001188_hyperpigmentation0.85532649
140MP0002092_abnormal_eye_morphology0.84509917
141MP0005388_respiratory_system_phenotype0.83038613
142MP0002133_abnormal_respiratory_system0.83038613
143MP0000955_abnormal_spinal_cord0.82486649
144MP0010368_abnormal_lymphatic_system0.82244901
145MP0000778_abnormal_nervous_system0.81035987
146MP0001486_abnormal_startle_reflex0.80270381
147MP0003075_altered_response_to0.79283368
148MP0002998_abnormal_bone_remodeling0.79023966
149MP0010386_abnormal_urinary_bladder0.78763357
150MP0002896_abnormal_bone_mineralization0.77478910
151MP0004133_heterotaxia0.76075833
152MP0010678_abnormal_skin_adnexa0.75793357
153MP0003936_abnormal_reproductive_system0.74160103
154MP0001529_abnormal_vocalization0.73184824
155MP0000003_abnormal_adipose_tissue0.72503180
156MP0003943_abnormal_hepatobiliary_system0.71731181
157MP0002557_abnormal_social/conspecific_i0.70807083
158MP0005448_abnormal_energy_balance0.70756982
159MP0004484_altered_response_of0.70630813
160MP0002184_abnormal_innervation0.70423740
161MP0003941_abnormal_skin_development0.69801778
162MP0005535_abnormal_body_temperature0.69698764
163MP0005275_abnormal_skin_tensile0.69551070
164MP0006072_abnormal_retinal_apoptosis0.69067186
165MP0001243_abnormal_dermal_layer0.68811393
166MP0008874_decreased_physiological_sensi0.68106591
167MP0001919_abnormal_reproductive_system0.67290309
168MP0003279_aneurysm0.67212201
169MP0002118_abnormal_lipid_homeostasis0.66088415
170MP0004742_abnormal_vestibular_system0.65406330
171MP0005253_abnormal_eye_physiology0.63904954
172MP0002152_abnormal_brain_morphology0.63659862
173MP0002272_abnormal_nervous_system0.61333547
174MP0009115_abnormal_fat_cell0.59862981
175MP0008872_abnormal_physiological_respon0.59695099
176MP0004019_abnormal_vitamin_homeostasis0.59446814
177MP0000733_abnormal_muscle_development0.59197165
178MP0003045_fibrosis0.58679803
179MP0004085_abnormal_heartbeat0.57362483
180MP0004147_increased_porphyrin_level0.56715654

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the parietal bone (HP:0002696)7.02420835
2Midline defect of the nose (HP:0004122)6.38655467
3Focal motor seizures (HP:0011153)5.52779511
4Nasolacrimal duct obstruction (HP:0000579)5.23649270
5Short 4th metacarpal (HP:0010044)5.09658473
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.09658473
7Trigonocephaly (HP:0000243)4.90543797
8Focal seizures (HP:0007359)4.77282983
9Aplasia involving bones of the extremities (HP:0009825)4.72630612
10Aplasia involving bones of the upper limbs (HP:0009823)4.72630612
11Aplasia of the phalanges of the hand (HP:0009802)4.72630612
12Scanning speech (HP:0002168)4.39021941
13Toxemia of pregnancy (HP:0100603)4.35907273
14Myokymia (HP:0002411)4.33952212
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.33310502
16Degeneration of the lateral corticospinal tracts (HP:0002314)4.33310502
17Febrile seizures (HP:0002373)4.32608090
18Abnormality of the nasal septum (HP:0000419)4.29361078
19Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.27921276
20Alacrima (HP:0000522)4.15545325
21Abnormality of the lacrimal duct (HP:0011481)4.14917614
22Mutism (HP:0002300)4.11721909
23Atonic seizures (HP:0010819)4.03669799
24Neurofibrillary tangles (HP:0002185)3.99524841
25Abnormality of the diencephalon (HP:0010662)3.94177457
26Abnormality of the corticospinal tract (HP:0002492)3.92967356
27Abnormality of the nasolacrimal system (HP:0000614)3.90123368
28White forelock (HP:0002211)3.80118351
29Anteriorly placed anus (HP:0001545)3.70207043
30Broad face (HP:0000283)3.63892855
31Ulnar claw (HP:0001178)3.60429201
32Epileptic encephalopathy (HP:0200134)3.56380413
33Neoplasm of the heart (HP:0100544)3.49765488
34Aplasia cutis congenita (HP:0001057)3.47842028
35Postural instability (HP:0002172)3.47742212
36Decreased lacrimation (HP:0000633)3.46488149
37Abnormality of binocular vision (HP:0011514)3.45445946
38Diplopia (HP:0000651)3.45445946
39Abnormality of the 4th metacarpal (HP:0010012)3.42656289
40Patchy hypopigmentation of hair (HP:0011365)3.37439915
41Large earlobe (HP:0009748)3.32839795
42Abnormality of incisor morphology (HP:0011063)3.26557251
43Spastic gait (HP:0002064)3.25924409
44Intention tremor (HP:0002080)3.25922679
45Depressed nasal tip (HP:0000437)3.25124110
46Complement deficiency (HP:0004431)3.24041525
47Abnormality of the proximal phalanges of the hand (HP:0009834)3.23706860
48Ankle clonus (HP:0011448)3.23320236
49Supranuclear gaze palsy (HP:0000605)3.22491305
50Glomerulonephritis (HP:0000099)3.20792773
51Anomalous pulmonary venous return (HP:0010772)3.19054237
52Synostosis involving the elbow (HP:0003938)3.18277200
53Humeroradial synostosis (HP:0003041)3.18277200
54Abnormality of the distal phalanx of the thumb (HP:0009617)3.17124583
55Broad metatarsal (HP:0001783)3.14539469
56Partial duplication of thumb phalanx (HP:0009944)3.13487754
57Progressive cerebellar ataxia (HP:0002073)3.13464328
58Dysmetria (HP:0001310)3.08090842
59Abnormal number of incisors (HP:0011064)3.03300366
60Partial duplication of the phalanx of hand (HP:0009999)3.02867998
61Vitreoretinal degeneration (HP:0000655)2.97254799
62Shallow orbits (HP:0000586)2.93242450
63Segmental peripheral demyelination/remyelination (HP:0003481)2.92709449
64Down-sloping shoulders (HP:0200021)2.91113844
65Overgrowth (HP:0001548)2.89290587
66Abnormality of the incisor (HP:0000676)2.89100151
67Coronal craniosynostosis (HP:0004440)2.86022770
68Supernumerary ribs (HP:0005815)2.82427392
69Chorioretinal atrophy (HP:0000533)2.81396392
70Abnormal eating behavior (HP:0100738)2.80771321
71Short phalanx of the thumb (HP:0009660)2.79098139
72Vaginal fistula (HP:0004320)2.75842008
73Concave nail (HP:0001598)2.74525081
74Abnormality of the pulmonary veins (HP:0011718)2.74458429
75Hemiplegia (HP:0002301)2.73225537
76Systemic lupus erythematosus (HP:0002725)2.71384693
77Gaze-evoked nystagmus (HP:0000640)2.70536924
78Lower limb muscle weakness (HP:0007340)2.69717033
79Microglossia (HP:0000171)2.69298421
80Rectovaginal fistula (HP:0000143)2.66853415
81Rectal fistula (HP:0100590)2.66853415
82Cerebral inclusion bodies (HP:0100314)2.64935440
83Bundle branch block (HP:0011710)2.64521551
84Generalized tonic-clonic seizures (HP:0002069)2.63877901
85Infantile muscular hypotonia (HP:0008947)2.63865297
86Abnormality of the middle phalanges of the toes (HP:0010183)2.59944321
87Abnormality of the labia minora (HP:0012880)2.59130983
88Truncal ataxia (HP:0002078)2.58392461
89Sparse lateral eyebrow (HP:0005338)2.58247143
90Neoplasm of the oral cavity (HP:0100649)2.57310583
91Exostoses (HP:0100777)2.56825201
92Absence seizures (HP:0002121)2.55245495
93Dysdiadochokinesis (HP:0002075)2.53010138
94Dialeptic seizures (HP:0011146)2.51351688
95Abnormality of the phalanges of the 2nd finger (HP:0009541)2.50579302
96Peripheral hypomyelination (HP:0007182)2.49607712
97Supernumerary bones of the axial skeleton (HP:0009144)2.49123838
98Intestinal fistula (HP:0100819)2.47301268
99Action tremor (HP:0002345)2.47190069
100Flat capital femoral epiphysis (HP:0003370)2.46750023
101Papilledema (HP:0001085)2.46278298
102Abnormality of the middle phalanges of the hand (HP:0009833)2.44920278
103Neuronal loss in central nervous system (HP:0002529)2.43588761
104Broad hallux (HP:0010055)2.43383950
105Split foot (HP:0001839)2.42630155
106Relative macrocephaly (HP:0004482)2.42611778
107Bell-shaped thorax (HP:0001591)2.42091814
108Turricephaly (HP:0000262)2.39338813
109Hypoplastic labia majora (HP:0000059)2.37588074
110Facial shape deformation (HP:0011334)2.34613614
111Potter facies (HP:0002009)2.34613614
112Broad toe (HP:0001837)2.34206932
113Abnormality of the periventricular white matter (HP:0002518)2.32303692
114Recurrent corneal erosions (HP:0000495)2.32149646
115Bilateral microphthalmos (HP:0007633)2.30907009
116Bronchomalacia (HP:0002780)2.29643384
117Torticollis (HP:0000473)2.27575168
118Anophthalmia (HP:0000528)2.26439173
119Urinary bladder sphincter dysfunction (HP:0002839)2.25249496
120Obstructive sleep apnea (HP:0002870)2.24012948
121Increased circulating renin level (HP:0000848)2.23566951
122Absent speech (HP:0001344)2.22464382
123Heart block (HP:0012722)2.18582328
124Cupped ear (HP:0000378)2.18375413
125Hyperaldosteronism (HP:0000859)2.17016800
126Deformed sella turcica (HP:0002681)2.15708657
127Xerostomia (HP:0000217)2.14087229
128Increased number of teeth (HP:0011069)2.14016797
129Conical tooth (HP:0000698)2.13629050
130Thickened helices (HP:0000391)2.13167751
131Aqueductal stenosis (HP:0002410)2.12937152
132Termporal pattern (HP:0011008)2.12288633
133Insidious onset (HP:0003587)2.12288633
134Abnormality of the labia majora (HP:0012881)2.10460679
135Rigidity (HP:0002063)2.09607570
136Hemivertebrae (HP:0002937)2.09439967
137Abnormality of complement system (HP:0005339)2.08391736
138Macroorchidism (HP:0000053)2.07323964
139Broad-based gait (HP:0002136)2.06603657
140Rapidly progressive (HP:0003678)2.06354889
141Retinal atrophy (HP:0001105)2.05854006
142Cerebral hypomyelination (HP:0006808)2.04582999
143Medulloblastoma (HP:0002885)2.03831045
144Milia (HP:0001056)2.03536732
145Abnormality of the sella turcica (HP:0002679)2.03487791
146Hemiparesis (HP:0001269)2.03140699
147Abnormality of the dental pulp (HP:0006479)2.02678290
148Hyperventilation (HP:0002883)2.01205370
149Amelogenesis imperfecta (HP:0000705)2.01169630
150Difficulty running (HP:0009046)1.99100029
151Stomach cancer (HP:0012126)1.98949436
152Metaphyseal dysplasia (HP:0100255)1.98542756
153Abnormal atrioventricular conduction (HP:0005150)1.98357815
154Morphological abnormality of the pyramidal tract (HP:0002062)1.98247728
155Abnormality of dental color (HP:0011073)1.96432096
156Mixed hearing impairment (HP:0000410)1.94937959
157Spastic tetraparesis (HP:0001285)1.93834502
158Bradykinesia (HP:0002067)1.93820445
159Metabolic alkalosis (HP:0200114)1.93732936
160Genetic anticipation (HP:0003743)1.93653680
161Depression (HP:0000716)1.93440197
162Bifid scrotum (HP:0000048)1.93391226
163Skin pits (HP:0100276)1.93170651
164Decreased motor nerve conduction velocity (HP:0003431)1.92562829
165Narrow palate (HP:0000189)1.92100630
166Abnormality of calcium-phosphate metabolism (HP:0100530)1.91938483
167Anal stenosis (HP:0002025)1.91202410
168Poor eye contact (HP:0000817)1.89445072
169Impaired vibration sensation in the lower limbs (HP:0002166)1.89244068
170Renal salt wasting (HP:0000127)1.87811230
171Visual hallucinations (HP:0002367)1.87363770
172Epileptiform EEG discharges (HP:0011182)1.86969651
173Syncope (HP:0001279)1.86107584
174Submucous cleft hard palate (HP:0000176)1.85943814
175Polyuria (HP:0000103)1.84196972
176Flat occiput (HP:0005469)1.84166261
177Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83872745
178Peritonitis (HP:0002586)1.83293257
179Blue irides (HP:0000635)1.83176308
180Abnormal hand bone ossification (HP:0010660)1.82439076
181Heterochromia iridis (HP:0001100)1.82393633
182Anxiety (HP:0000739)1.82199127
183Hyporeflexia of lower limbs (HP:0002600)1.81614439
184Telecanthus (HP:0000506)1.81214048
185Limb dystonia (HP:0002451)1.80272673
186Impaired proprioception (HP:0010831)1.79424162
187Urinary urgency (HP:0000012)1.78486805
188Hypokalemic alkalosis (HP:0001949)1.78332309
189Drooling (HP:0002307)1.78020871
190Clonus (HP:0002169)1.77977286
191Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.75390675
192Ventricular fibrillation (HP:0001663)1.75125372
193Tetraplegia (HP:0002445)1.74162947
194Choreoathetosis (HP:0001266)1.74000267
195Sleep apnea (HP:0010535)1.73888102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR25.96012825
2NTRK24.37423979
3NTRK33.18095097
4LATS13.09480644
5DDR22.73881796
6STK392.68458555
7DAPK22.59630900
8CSNK1A1L2.57054460
9MARK12.55169083
10EPHB12.53644715
11NLK2.40701648
12PIK3CA2.39601797
13STK242.28921313
14NUAK12.27504251
15PAK62.26158112
16MAP3K92.22865575
17FER2.15138073
18CASK2.14780574
19MAPKAPK52.03901845
20CAMK1G1.98964101
21GRK51.82860276
22PINK11.82360737
23FGFR11.79201657
24EPHA31.76346509
25MINK11.71682957
26PNCK1.69353580
27SIK11.56898536
28MAPK151.54497330
29CAMKK11.53374965
30PDGFRB1.52628060
31CAMKK21.52132609
32IRAK11.50675831
33MAP3K131.45788595
34WNK11.44788045
35FRK1.42633193
36AKT31.41021325
37CAMK1D1.40434887
38CSNK1G11.37685355
39BMX1.36205606
40OXSR11.35527348
41ARAF1.34301503
42TGFBR21.31743815
43MARK21.29878608
44PRKCE1.26368151
45CSNK1G31.21836034
46PRPF4B1.21814512
47BCR1.20222045
48MAP3K21.19738108
49MAPK121.17312363
50GRK71.15326875
51CAMK2G1.13510963
52IRAK21.11823994
53CSNK1G21.09837682
54TNIK1.08646060
55PKN11.07362596
56PDGFRA1.06460647
57NEK61.05121245
58DYRK21.05116351
59PDK21.02359130
60INSRR1.00470640
61PRKD30.97949754
62CAMK2D0.96479011
63YES10.95616180
64PRKCG0.94007898
65RIPK40.91728868
66STK30.88229233
67SGK4940.88060148
68SGK2230.88060148
69PDK10.86306669
70PRKD10.85154519
71MAP3K40.83464729
72PAK30.82472925
73STK380.81455969
74SGK10.81444157
75MOS0.79523559
76LATS20.78540911
77DYRK1A0.77816308
78STK110.77145515
79DMPK0.77137520
80MAPK100.74756993
81CSF1R0.74257305
82BMPR1B0.74039673
83WNK40.73863443
84MKNK20.72180299
85JAK20.72089926
86PDPK10.70723134
87GSK3A0.70530318
88CCNB10.69813814
89PRKCQ0.69182360
90MAP3K70.68625305
91PRKG10.68008925
92ERBB20.67110030
93ERBB30.66588908
94HIPK20.66354024
95CAMK2B0.65161697
96KSR20.64843872
97NTRK10.64191959
98CAMK40.64038602
99PHKG10.63446841
100PHKG20.63446841
101STK38L0.62318298
102PTK2B0.61112663
103RET0.60984189
104CSNK1A10.60946331
105RIPK10.60351845
106UHMK10.60221367
107PRKCH0.59693971
108RPS6KA30.59219963
109MAP4K20.58930402
110TNK20.58821101
111MAPK70.58672986
112PLK20.56474607
113GRK10.55785971
114ROCK20.55379952
115DAPK10.54632000
116MAPK130.54309185
117CAMK2A0.54089576
118CLK10.53539014
119JAK10.52194511
120SIK30.50926961
121MET0.50910066
122NME10.50540913
123MST40.49860697
124CDC42BPA0.49244803
125EPHA40.48619636
126CDK50.48052224
127LIMK10.47728043
128ADRBK20.47705358
129FYN0.47490062
130PRKACA0.47375432
131PBK0.47328860
132MAP2K10.47168369
133PRKAA20.46381757
134INSR0.46158530
135PRKCA0.45928026
136ADRBK10.45130785
137SGK30.44259182
138ABL10.42971737
139CDK30.42961379
140PRKCZ0.42611056
141CSK0.41647532
142BMPR20.40785251
143SGK20.40688201
144MAPK40.40343671
145CAMK10.39078245
146CHUK0.37174341
147ROCK10.35358041
148MAPK10.35118710
149PTK20.34601790
150ZAK0.34539710
151IGF1R0.34456252
152SIK20.32240708
153SRC0.31928825
154EPHB20.30885652

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.28102396
2Hedgehog signaling pathway_Homo sapiens_hsa043404.26122237
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74473558
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.69597992
5Melanoma_Homo sapiens_hsa052182.61285766
6Synaptic vesicle cycle_Homo sapiens_hsa047212.46413848
7ECM-receptor interaction_Homo sapiens_hsa045122.14697928
8Long-term potentiation_Homo sapiens_hsa047202.10448069
9Wnt signaling pathway_Homo sapiens_hsa043102.07455961
10Sulfur metabolism_Homo sapiens_hsa009202.06215721
11Insulin secretion_Homo sapiens_hsa049111.99745847
12Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.97406755
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79982460
14Axon guidance_Homo sapiens_hsa043601.70548292
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69909887
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.63271173
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60477299
18Bile secretion_Homo sapiens_hsa049761.53251495
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51777818
20Pathways in cancer_Homo sapiens_hsa052001.50234749
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50142672
22Prostate cancer_Homo sapiens_hsa052151.49606274
23TGF-beta signaling pathway_Homo sapiens_hsa043501.48538354
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47042281
25Adherens junction_Homo sapiens_hsa045201.47002893
26Circadian rhythm_Homo sapiens_hsa047101.45193964
27Oxytocin signaling pathway_Homo sapiens_hsa049211.44623729
28Retinol metabolism_Homo sapiens_hsa008301.40240282
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35805711
30Hippo signaling pathway_Homo sapiens_hsa043901.35679334
31Pancreatic secretion_Homo sapiens_hsa049721.34883880
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33568537
33Steroid biosynthesis_Homo sapiens_hsa001001.30834441
34Thyroid hormone synthesis_Homo sapiens_hsa049181.29685966
35Chemical carcinogenesis_Homo sapiens_hsa052041.28223862
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24802413
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.20980784
38cAMP signaling pathway_Homo sapiens_hsa040241.19585535
39Dilated cardiomyopathy_Homo sapiens_hsa054141.19233486
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18706576
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18500377
42Renin secretion_Homo sapiens_hsa049241.16816927
43Gap junction_Homo sapiens_hsa045401.16670698
44Ras signaling pathway_Homo sapiens_hsa040141.15625615
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14909679
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12173629
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11701801
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.11159845
49Starch and sucrose metabolism_Homo sapiens_hsa005001.10293266
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09524905
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.08885306
52Rap1 signaling pathway_Homo sapiens_hsa040151.07777976
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07496915
54Proteoglycans in cancer_Homo sapiens_hsa052051.05274788
55Focal adhesion_Homo sapiens_hsa045101.03917760
56Cocaine addiction_Homo sapiens_hsa050301.02993382
57Amoebiasis_Homo sapiens_hsa051461.00937521
58beta-Alanine metabolism_Homo sapiens_hsa004100.99988520
59Prion diseases_Homo sapiens_hsa050200.97873915
60Cholinergic synapse_Homo sapiens_hsa047250.97796767
61ErbB signaling pathway_Homo sapiens_hsa040120.96903743
62MAPK signaling pathway_Homo sapiens_hsa040100.96450147
63Melanogenesis_Homo sapiens_hsa049160.87550100
64Tight junction_Homo sapiens_hsa045300.85535006
65Dorso-ventral axis formation_Homo sapiens_hsa043200.84212955
66Small cell lung cancer_Homo sapiens_hsa052220.83384811
67Inositol phosphate metabolism_Homo sapiens_hsa005620.83246006
68Mineral absorption_Homo sapiens_hsa049780.82271357
69Amphetamine addiction_Homo sapiens_hsa050310.81630807
70Colorectal cancer_Homo sapiens_hsa052100.76979809
71Fatty acid biosynthesis_Homo sapiens_hsa000610.76959569
72Nitrogen metabolism_Homo sapiens_hsa009100.76273393
73Ether lipid metabolism_Homo sapiens_hsa005650.76090168
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74468895
75Arginine and proline metabolism_Homo sapiens_hsa003300.73732614
76Ovarian steroidogenesis_Homo sapiens_hsa049130.73123924
77PPAR signaling pathway_Homo sapiens_hsa033200.72683603
78ABC transporters_Homo sapiens_hsa020100.71496876
79Morphine addiction_Homo sapiens_hsa050320.70455249
80Olfactory transduction_Homo sapiens_hsa047400.69735736
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68745088
82Protein digestion and absorption_Homo sapiens_hsa049740.68531671
83Glutamatergic synapse_Homo sapiens_hsa047240.65575910
84Serotonergic synapse_Homo sapiens_hsa047260.65204407
85Endometrial cancer_Homo sapiens_hsa052130.64866493
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63931691
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62686961
88Gastric acid secretion_Homo sapiens_hsa049710.62451789
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62149669
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62096678
91GABAergic synapse_Homo sapiens_hsa047270.61683802
92Staphylococcus aureus infection_Homo sapiens_hsa051500.61172424
93Type II diabetes mellitus_Homo sapiens_hsa049300.60087687
94Phototransduction_Homo sapiens_hsa047440.59922739
95Viral myocarditis_Homo sapiens_hsa054160.59084507
96Nicotine addiction_Homo sapiens_hsa050330.58960586
97Taste transduction_Homo sapiens_hsa047420.58942286
98MicroRNAs in cancer_Homo sapiens_hsa052060.58474561
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58169173
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57922360
101Toxoplasmosis_Homo sapiens_hsa051450.56789009
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56775547
103Collecting duct acid secretion_Homo sapiens_hsa049660.56478825
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.55461038
105Sphingolipid metabolism_Homo sapiens_hsa006000.54787329
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54736507
107Dopaminergic synapse_Homo sapiens_hsa047280.54186580
108Complement and coagulation cascades_Homo sapiens_hsa046100.53510140
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.52622994
110Fatty acid elongation_Homo sapiens_hsa000620.52517705
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52464513
112Circadian entrainment_Homo sapiens_hsa047130.51483586
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51129796
114Linoleic acid metabolism_Homo sapiens_hsa005910.51114402
115Renal cell carcinoma_Homo sapiens_hsa052110.50962763
116Oocyte meiosis_Homo sapiens_hsa041140.50670291
117Estrogen signaling pathway_Homo sapiens_hsa049150.49936519
118Long-term depression_Homo sapiens_hsa047300.49827384
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49709773
120Glioma_Homo sapiens_hsa052140.49516280
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49350447
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.48887528
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48610088
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47897334
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.47469465
126Platelet activation_Homo sapiens_hsa046110.47012901
127Vitamin B6 metabolism_Homo sapiens_hsa007500.45888531
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44805880
129Butanoate metabolism_Homo sapiens_hsa006500.42858011
130Choline metabolism in cancer_Homo sapiens_hsa052310.42693897
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42576903
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42017830
133Vibrio cholerae infection_Homo sapiens_hsa051100.41783595
134Salivary secretion_Homo sapiens_hsa049700.40430244
135Glucagon signaling pathway_Homo sapiens_hsa049220.39046679
136GnRH signaling pathway_Homo sapiens_hsa049120.38801515
137Histidine metabolism_Homo sapiens_hsa003400.38323182
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.37905351
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37880915
140Calcium signaling pathway_Homo sapiens_hsa040200.37574499
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37345508
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36971471
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36645575
144Phagosome_Homo sapiens_hsa041450.35700103
145AMPK signaling pathway_Homo sapiens_hsa041520.35302789
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35276643
147Endocytosis_Homo sapiens_hsa041440.35056746
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.34204318
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30702155

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