GLE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.17768596
2nuclear pore complex assembly (GO:0051292)4.97966928
3DNA replication checkpoint (GO:0000076)4.85608473
4purine nucleobase biosynthetic process (GO:0009113)4.63474904
5Golgi transport vesicle coating (GO:0048200)4.58448653
6COPI coating of Golgi vesicle (GO:0048205)4.58448653
7DNA replication initiation (GO:0006270)4.56640032
8nucleobase biosynthetic process (GO:0046112)4.52125709
9protein localization to kinetochore (GO:0034501)4.49228767
10DNA strand elongation involved in DNA replication (GO:0006271)4.44003420
11metaphase plate congression (GO:0051310)4.27830291
12maturation of 5.8S rRNA (GO:0000460)4.25646925
13DNA strand elongation (GO:0022616)4.25549580
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.20879218
15folic acid metabolic process (GO:0046655)4.19830238
16nuclear pore organization (GO:0006999)4.06940517
17attachment of spindle microtubules to kinetochore (GO:0008608)4.04238046
18protein localization to chromosome, centromeric region (GO:0071459)4.03953410
19mitotic chromosome condensation (GO:0007076)4.01779434
20CENP-A containing nucleosome assembly (GO:0034080)3.94678974
21chromatin remodeling at centromere (GO:0031055)3.92807929
22ribosome biogenesis (GO:0042254)3.88090435
23telomere maintenance via semi-conservative replication (GO:0032201)3.87142155
24regulation of spindle organization (GO:0090224)3.84226258
25mitotic nuclear envelope disassembly (GO:0007077)3.83802193
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.83758199
27DNA replication-independent nucleosome assembly (GO:0006336)3.81666228
28DNA replication-independent nucleosome organization (GO:0034724)3.81666228
29pore complex assembly (GO:0046931)3.77836577
30DNA unwinding involved in DNA replication (GO:0006268)3.77692162
31DNA deamination (GO:0045006)3.76292805
32mitotic sister chromatid segregation (GO:0000070)3.70423767
33maturation of SSU-rRNA (GO:0030490)3.70063919
34folic acid-containing compound biosynthetic process (GO:0009396)3.58822462
35membrane disassembly (GO:0030397)3.57321489
36nuclear envelope disassembly (GO:0051081)3.57321489
37negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.53676011
38establishment of chromosome localization (GO:0051303)3.52679238
39positive regulation of chromosome segregation (GO:0051984)3.50373977
40telomere maintenance via recombination (GO:0000722)3.50362922
41DNA replication-dependent nucleosome organization (GO:0034723)3.49111065
42DNA replication-dependent nucleosome assembly (GO:0006335)3.49111065
43histone exchange (GO:0043486)3.46155281
44regulation of chromosome segregation (GO:0051983)3.45925494
45chromosome condensation (GO:0030261)3.45559817
46negative regulation of chromosome segregation (GO:0051985)3.45553126
47mismatch repair (GO:0006298)3.43601805
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43212145
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.43212145
50ribosome assembly (GO:0042255)3.42530998
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.42276272
52negative regulation of sister chromatid segregation (GO:0033046)3.42276272
53negative regulation of mitotic sister chromatid separation (GO:2000816)3.42276272
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.42276272
55spindle checkpoint (GO:0031577)3.40661141
56mitotic spindle assembly checkpoint (GO:0007094)3.39429063
57mitotic sister chromatid cohesion (GO:0007064)3.38399619
58protein localization to chromosome (GO:0034502)3.36980878
59telomere maintenance via telomere lengthening (GO:0010833)3.33453286
60spindle assembly checkpoint (GO:0071173)3.32738296
61mitotic recombination (GO:0006312)3.31613011
62regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30589299
63pentose-phosphate shunt (GO:0006098)3.30177757
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.28633230
65IMP biosynthetic process (GO:0006188)3.27009778
66mitotic spindle checkpoint (GO:0071174)3.25294249
67spliceosomal snRNP assembly (GO:0000387)3.24294286
68kinetochore assembly (GO:0051382)3.22460442
69regulation of mitotic metaphase/anaphase transition (GO:0030071)3.21303762
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19985494
71sister chromatid segregation (GO:0000819)3.19423559
72chromosome segregation (GO:0007059)3.17930665
73rRNA modification (GO:0000154)3.17633991
74kinetochore organization (GO:0051383)3.16253336
75DNA synthesis involved in DNA repair (GO:0000731)3.14157626
76DNA topological change (GO:0006265)3.12848589
77monoubiquitinated protein deubiquitination (GO:0035520)3.12194109
78DNA packaging (GO:0006323)3.11621360
79histone H2A monoubiquitination (GO:0035518)3.11351819
80retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.10877209
81negative regulation of DNA-templated transcription, elongation (GO:0032785)3.09509538
82negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.09509538
83regulation of sister chromatid segregation (GO:0033045)3.09429526
84regulation of mitotic sister chromatid separation (GO:0010965)3.09429526
85regulation of mitotic sister chromatid segregation (GO:0033047)3.09429526
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.07204958
87chromatin assembly or disassembly (GO:0006333)3.04814472
88negative regulation of meiosis (GO:0045835)3.04547191
89ribonucleoprotein complex biogenesis (GO:0022613)3.03314200
90peptidyl-arginine omega-N-methylation (GO:0035247)3.01104482
91formation of translation preinitiation complex (GO:0001731)3.01040236
92dosage compensation (GO:0007549)3.01006531
93regulation of translational fidelity (GO:0006450)3.00208676
94IMP metabolic process (GO:0046040)2.99662653
95regulation of mitotic spindle organization (GO:0060236)2.98302050
96ATP-dependent chromatin remodeling (GO:0043044)2.97764496
97regulation of sister chromatid cohesion (GO:0007063)2.96003861
98spliceosomal tri-snRNP complex assembly (GO:0000244)2.95213082
99regulation of translation in response to stress (GO:0043555)2.95120656
100rRNA processing (GO:0006364)2.94274371
101regulation of meiosis I (GO:0060631)2.93429083
102meiotic chromosome segregation (GO:0045132)2.92558285
103DNA damage response, signal transduction resulting in transcription (GO:0042772)2.90950905
104histone H2A acetylation (GO:0043968)2.90245557
105NADPH regeneration (GO:0006740)2.89961636
106histone H2A ubiquitination (GO:0033522)2.89093345
107transcription-coupled nucleotide-excision repair (GO:0006283)2.87839726
108positive regulation of mitotic sister chromatid separation (GO:1901970)2.86574262
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86574262
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86574262
111rRNA metabolic process (GO:0016072)2.86350190
112proline biosynthetic process (GO:0006561)2.85613525
113intra-S DNA damage checkpoint (GO:0031573)2.85247540
114protein deneddylation (GO:0000338)2.84190617
115DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.84119216
116cellular response to interleukin-4 (GO:0071353)2.78996939
117nuclear envelope organization (GO:0006998)2.76284137
118establishment of integrated proviral latency (GO:0075713)2.74306235
119regulation of histone H3-K27 methylation (GO:0061085)2.70288982
120nucleobase-containing small molecule interconversion (GO:0015949)2.69453538
121protein maturation by protein folding (GO:0022417)2.66892780
122DNA conformation change (GO:0071103)2.62484270
123protein export from nucleus (GO:0006611)2.60926019
124hepatocyte apoptotic process (GO:0097284)2.58862326
125DNA duplex unwinding (GO:0032508)2.54120076
126regulation of RNA export from nucleus (GO:0046831)2.49869463
127histone H3-K36 demethylation (GO:0070544)2.49754869
128negative regulation of cell size (GO:0045792)2.49688662
129COPII vesicle coating (GO:0048208)2.49412448
130establishment of viral latency (GO:0019043)2.47960602
131deoxyribonucleotide biosynthetic process (GO:0009263)2.46383696
132positive regulation of gamma-delta T cell activation (GO:0046645)2.45333019
133NIK/NF-kappaB signaling (GO:0038061)2.44630696
134positive regulation of Cdc42 GTPase activity (GO:0043089)2.44312398
135chaperone mediated protein folding requiring cofactor (GO:0051085)2.43077731
136sister chromatid cohesion (GO:0007062)2.41593216
137response to interleukin-4 (GO:0070670)2.41056716
138mitochondrial DNA metabolic process (GO:0032042)2.39141269
139glucose catabolic process (GO:0006007)2.37840854
140DNA geometric change (GO:0032392)2.36591659
141positive regulation of keratinocyte differentiation (GO:0045618)2.36182688
142gonadal mesoderm development (GO:0007506)2.34530114
143necroptotic process (GO:0070266)2.30282062
1443-UTR-mediated mRNA stabilization (GO:0070935)2.30242078
145tRNA aminoacylation for protein translation (GO:0006418)2.28012081
146mitochondrial fusion (GO:0008053)2.26422310
147positive regulation of T cell cytokine production (GO:0002726)2.26082320
148regulation of centriole replication (GO:0046599)2.25320014
149tRNA aminoacylation (GO:0043039)2.23673184
150amino acid activation (GO:0043038)2.23673184
151protoporphyrinogen IX metabolic process (GO:0046501)2.23097248
152non-recombinational repair (GO:0000726)2.20306924
153double-strand break repair via nonhomologous end joining (GO:0006303)2.20306924
154vesicle coating (GO:0006901)2.19372475
155glucose 6-phosphate metabolic process (GO:0051156)2.16316435
156protein localization to endosome (GO:0036010)2.12837278
157regulation of transcription from RNA polymerase I promoter (GO:0006356)2.12117611
158glycolytic process (GO:0006096)2.12088495
159programmed necrotic cell death (GO:0097300)2.12047990
160antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.11813957
161negative regulation of defense response to virus (GO:0050687)2.10582971
162regulation of nucleobase-containing compound transport (GO:0032239)2.10550288
163regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.10440578
164antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.09468644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.26724870
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.46043233
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.99837569
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60225577
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37307686
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.37124859
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25607942
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15418136
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.97693306
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89339280
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83499491
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79381196
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77592133
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.72866322
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.70786109
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70221979
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65784446
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47379521
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38891429
20AR_21909140_ChIP-Seq_LNCAP_Human2.32659990
21XRN2_22483619_ChIP-Seq_HELA_Human2.31922300
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17262318
23VDR_23849224_ChIP-Seq_CD4+_Human2.13628130
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10674005
25GABP_19822575_ChIP-Seq_HepG2_Human2.09763329
26FOXP3_21729870_ChIP-Seq_TREG_Human2.09245100
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08117219
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06833835
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99664457
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.96331647
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95834179
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92482770
33DCP1A_22483619_ChIP-Seq_HELA_Human1.91444413
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88714873
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87652873
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86751035
37CIITA_25753668_ChIP-Seq_RAJI_Human1.85888729
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84331781
39MYC_22102868_ChIP-Seq_BL_Human1.79622523
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73252427
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73042588
42TTF2_22483619_ChIP-Seq_HELA_Human1.71728873
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.68448299
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66456356
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65371729
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.63797519
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62239959
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61510156
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.60952786
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59204088
51KDM5A_27292631_Chip-Seq_BREAST_Human1.59078190
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57591623
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54630386
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54505690
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52766058
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50708486
57SPI1_23547873_ChIP-Seq_NB4_Human1.49158661
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44106585
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40380302
60MAF_26560356_Chip-Seq_TH1_Human1.40286208
61GATA1_22025678_ChIP-Seq_K562_Human1.40033190
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.39609014
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38394609
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36069850
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34808649
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33069812
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33035283
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31403172
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30074340
70* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29315157
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28287645
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27908460
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25021760
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23963414
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.23744132
76MYB_26560356_Chip-Seq_TH1_Human1.23344844
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22689773
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22420818
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21851792
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21322730
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.21277534
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21250720
83UTX_26944678_Chip-Seq_JUKART_Human1.19426737
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.18996296
85MYB_26560356_Chip-Seq_TH2_Human1.18603578
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18521533
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16987529
88* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16258895
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15659632
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13761741
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13098267
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12794662
93* RUNX1_22412390_ChIP-Seq_EML_Mouse1.11126603
94ZNF263_19887448_ChIP-Seq_K562_Human1.10839092
95* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10468144
96MAF_26560356_Chip-Seq_TH2_Human1.09937997
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09673277
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06802673
99MYC_18940864_ChIP-ChIP_HL60_Human1.05585055
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03504576
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03436657
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03118073
103* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03047367
104NCOR1_26117541_ChIP-Seq_K562_Human1.02552685
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02510842
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01935435
107CHD1_26751641_Chip-Seq_LNCaP_Human1.01815155
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01806837
109PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01281408
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00601762
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.99838026
112TCF7_22412390_ChIP-Seq_EML_Mouse0.99817303
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.99619873
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.98981283
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97913868
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97387876
117ELK1_19687146_ChIP-ChIP_HELA_Human0.91966327
118* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91181025
119TFEB_21752829_ChIP-Seq_HELA_Human0.86890374
120IRF1_19129219_ChIP-ChIP_H3396_Human0.86598117
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85026286
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84034393
123* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83629588
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79334842
125* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78462583
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78343187
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76396172
128VDR_21846776_ChIP-Seq_THP-1_Human0.74817979
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72357364
130FOXP1_21924763_ChIP-Seq_HESCs_Human0.72017230
131KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71838683
132POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.70549964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.78229035
2MP0010094_abnormal_chromosome_stability5.13365724
3MP0003111_abnormal_nucleus_morphology4.87741539
4MP0003077_abnormal_cell_cycle4.04063288
5MP0004957_abnormal_blastocyst_morpholog3.85455004
6MP0003718_maternal_effect3.54750404
7MP0008877_abnormal_DNA_methylation3.41534780
8MP0008058_abnormal_DNA_repair3.36204591
9MP0010234_abnormal_vibrissa_follicle2.96551790
10MP0002877_abnormal_melanocyte_morpholog2.84099842
11MP0008057_abnormal_DNA_replication2.81353373
12MP0003123_paternal_imprinting2.70002483
13MP0002396_abnormal_hematopoietic_system2.62204461
14MP0008007_abnormal_cellular_replicative2.60417803
15MP0001730_embryonic_growth_arrest2.33983399
16MP0003646_muscle_fatigue2.32375866
17MP0004233_abnormal_muscle_weight2.31398564
18MP0002653_abnormal_ependyma_morphology2.30773380
19MP0008932_abnormal_embryonic_tissue2.20126417
20MP0002102_abnormal_ear_morphology2.17548753
21MP0000350_abnormal_cell_proliferation2.01849616
22MP0003786_premature_aging1.96351219
23MP0005058_abnormal_lysosome_morphology1.95545277
24MP0006292_abnormal_olfactory_placode1.95199590
25MP0003121_genomic_imprinting1.89182171
26MP0001835_abnormal_antigen_presentation1.85706249
27MP0002166_altered_tumor_susceptibility1.84965362
28MP0009840_abnormal_foam_cell1.81320132
29MP0008260_abnormal_autophagy1.79669275
30MP0010307_abnormal_tumor_latency1.78608568
31MP0002210_abnormal_sex_determination1.76564430
32MP0003656_abnormal_erythrocyte_physiolo1.71293412
33MP0002006_tumorigenesis1.69178358
34MP0001672_abnormal_embryogenesis/_devel1.66518033
35MP0005380_embryogenesis_phenotype1.66518033
36MP0001929_abnormal_gametogenesis1.65921249
37MP0004147_increased_porphyrin_level1.63388034
38MP0005451_abnormal_body_composition1.63284639
39MP0003806_abnormal_nucleotide_metabolis1.62375473
40MP0003436_decreased_susceptibility_to1.60700629
41MP0004808_abnormal_hematopoietic_stem1.58833546
42MP0000685_abnormal_immune_system1.57983459
43MP0001697_abnormal_embryo_size1.57848162
44MP0002080_prenatal_lethality1.53990595
45MP0005671_abnormal_response_to1.53271985
46MP0000653_abnormal_sex_gland1.53204803
47MP0002085_abnormal_embryonic_tissue1.52188009
48MP0001119_abnormal_female_reproductive1.48201409
49MP0001853_heart_inflammation1.47864679
50MP0000490_abnormal_crypts_of1.44533136
51MP0003300_gastrointestinal_ulcer1.40937830
52MP0002009_preneoplasia1.39897534
53MP0001145_abnormal_male_reproductive1.38602867
54MP0003699_abnormal_female_reproductive1.36895065
55MP0004947_skin_inflammation1.36331447
56MP0003984_embryonic_growth_retardation1.35642932
57MP0002088_abnormal_embryonic_growth/wei1.35302293
58MP0002019_abnormal_tumor_incidence1.34105294
59MP0002084_abnormal_developmental_patter1.31685964
60MP0005310_abnormal_salivary_gland1.31194047
61MP0008995_early_reproductive_senescence1.30941052
62MP0000313_abnormal_cell_death1.30263236
63MP0009333_abnormal_splenocyte_physiolog1.28560034
64MP0005387_immune_system_phenotype1.28349439
65MP0001790_abnormal_immune_system1.28349439
66MP0001873_stomach_inflammation1.27918539
67MP0003191_abnormal_cellular_cholesterol1.26316591
68MP0003705_abnormal_hypodermis_morpholog1.25988700
69MP0005464_abnormal_platelet_physiology1.24746423
70MP0005000_abnormal_immune_tolerance1.23109878
71MP0005076_abnormal_cell_differentiation1.23074384
72MP0001800_abnormal_humoral_immune1.21835611
73MP0002723_abnormal_immune_serum1.21336882
74MP0002132_abnormal_respiratory_system1.20230477
75MP0005025_abnormal_response_to1.18993137
76MP0005501_abnormal_skin_physiology1.18507945
77MP0004185_abnormal_adipocyte_glucose1.17871454
78MP0003787_abnormal_imprinting1.15647110
79MP0003453_abnormal_keratinocyte_physiol1.15555619
80MP0005397_hematopoietic_system_phenotyp1.15430494
81MP0001545_abnormal_hematopoietic_system1.15430494
82MP0005248_abnormal_Harderian_gland1.15034546
83MP0002420_abnormal_adaptive_immunity1.14463618
84MP0002452_abnormal_antigen_presenting1.14322373
85MP0001819_abnormal_immune_cell1.13537375
86MP0005408_hypopigmentation1.12528478
87MP0000465_gastrointestinal_hemorrhage1.11662764
88MP0009785_altered_susceptibility_to1.10790835
89MP0003315_abnormal_perineum_morphology1.09854969
90MP0002086_abnormal_extraembryonic_tissu1.07474317
91MP0002163_abnormal_gland_morphology1.07390315
92MP0003303_peritoneal_inflammation1.07026462
93MP0000716_abnormal_immune_system1.05909399
94MP0002796_impaired_skin_barrier1.03140409
95MP0002161_abnormal_fertility/fecundity1.02740170
96MP0001216_abnormal_epidermal_layer1.02455623
97MP0005395_other_phenotype1.01235023
98MP0001348_abnormal_lacrimal_gland1.01189773
99MP0010155_abnormal_intestine_physiology1.00501493
100MP0000858_altered_metastatic_potential1.00432073
101MP0002419_abnormal_innate_immunity0.97828765
102MP0009697_abnormal_copulation0.96030706
103MP0009672_abnormal_birth_weight0.94372081
104MP0004264_abnormal_extraembryonic_tissu0.94057247
105MP0000627_abnormal_mammary_gland0.92649185
106MP0005409_darkened_coat_color0.91941701
107MP0003698_abnormal_male_reproductive0.91723788
108MP0001661_extended_life_span0.90568588
109MP0002405_respiratory_system_inflammati0.90375929
110MP0000015_abnormal_ear_pigmentation0.90356513
111MP0010352_gastrointestinal_tract_polyps0.89963797
112MP0003172_abnormal_lysosome_physiology0.89682130
113MP0001919_abnormal_reproductive_system0.89137177
114MP0002160_abnormal_reproductive_system0.88632962
115MP0003221_abnormal_cardiomyocyte_apopto0.88350252
116MP0001881_abnormal_mammary_gland0.87125440
117MP0001845_abnormal_inflammatory_respons0.86071407
118MP0000703_abnormal_thymus_morphology0.85358885
119MP0003119_abnormal_digestive_system0.85355825
120MP0001915_intracranial_hemorrhage0.83761230
121MP0002148_abnormal_hypersensitivity_rea0.83052742
122MP0002398_abnormal_bone_marrow0.82267200
123MP0003763_abnormal_thymus_physiology0.79834759
124MP0005389_reproductive_system_phenotype0.79417811
125MP0000371_diluted_coat_color0.78259059
126MP0005384_cellular_phenotype0.77181406
127MP0005621_abnormal_cell_physiology0.75037756
128MP0000689_abnormal_spleen_morphology0.74901276
129MP0006035_abnormal_mitochondrial_morpho0.74721995
130MP0000537_abnormal_urethra_morphology0.74504938
131MP0004197_abnormal_fetal_growth/weight/0.74307864
132MP0005075_abnormal_melanosome_morpholog0.72456338
133MP0002095_abnormal_skin_pigmentation0.71848510
134MP0002722_abnormal_immune_system0.70185630
135MP0003861_abnormal_nervous_system0.65369758
136MP0002269_muscular_atrophy0.63821485
137MP0005187_abnormal_penis_morphology0.62818130
138MP0003937_abnormal_limbs/digits/tail_de0.61166496
139MP0005266_abnormal_metabolism0.60052750
140MP0005174_abnormal_tail_pigmentation0.59345156
141MP0003567_abnormal_fetal_cardiomyocyte0.58609916
142MP0000428_abnormal_craniofacial_morphol0.57459002
143MP0001849_ear_inflammation0.55931401
144MP0002429_abnormal_blood_cell0.55143074
145MP0002075_abnormal_coat/hair_pigmentati0.54982931
146MP0000358_abnormal_cell_content/0.54891485
147MP0010030_abnormal_orbit_morphology0.54421665
148MP0002970_abnormal_white_adipose0.52531444
149MP0001727_abnormal_embryo_implantation0.48102347
150MP0009703_decreased_birth_body0.47962805
151MP0000733_abnormal_muscle_development0.47086713
152MP0002111_abnormal_tail_morphology0.46556475
153MP0002938_white_spotting0.46222270

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.55089132
2Patellar aplasia (HP:0006443)4.19110221
3Ependymoma (HP:0002888)4.06020000
4Breast hypoplasia (HP:0003187)3.99221179
5Aplasia/Hypoplasia of the patella (HP:0006498)3.89588790
6Cholecystitis (HP:0001082)3.88984825
7Abnormal gallbladder physiology (HP:0012438)3.88984825
8Cerebral hypomyelination (HP:0006808)3.83904414
9Chromsome breakage (HP:0040012)3.66021935
10Abnormality of the labia minora (HP:0012880)3.60501199
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.54507138
12Carpal bone hypoplasia (HP:0001498)3.39256751
13Aplastic anemia (HP:0001915)3.38571447
14Medulloblastoma (HP:0002885)3.36916636
15Oral leukoplakia (HP:0002745)3.33834448
16Rhabdomyosarcoma (HP:0002859)3.33276245
17Cutaneous melanoma (HP:0012056)3.27997285
18Premature ovarian failure (HP:0008209)3.17193646
19Meckel diverticulum (HP:0002245)3.14242922
20Abnormality of chromosome stability (HP:0003220)3.11425252
21Abnormality of the ileum (HP:0001549)3.08907778
22Secondary amenorrhea (HP:0000869)3.08119019
23Agnosia (HP:0010524)3.05787259
24Abnormality of the preputium (HP:0100587)3.03410949
25Ragged-red muscle fibers (HP:0003200)3.01981743
26Resting tremor (HP:0002322)2.94210742
27Impulsivity (HP:0100710)2.88711719
28Recurrent viral infections (HP:0004429)2.87084016
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.86709374
30Astrocytoma (HP:0009592)2.83949516
31Abnormality of the astrocytes (HP:0100707)2.83949516
32Menstrual irregularities (HP:0000858)2.78565884
33Duodenal stenosis (HP:0100867)2.77307569
34Small intestinal stenosis (HP:0012848)2.77307569
35Myelodysplasia (HP:0002863)2.76934489
36Abnormality of glycolysis (HP:0004366)2.73518275
37Amaurosis fugax (HP:0100576)2.73313790
38Progressive external ophthalmoplegia (HP:0000590)2.72983988
39Proximal placement of thumb (HP:0009623)2.71737739
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.70313204
41Abnormal spermatogenesis (HP:0008669)2.66338748
42Glioma (HP:0009733)2.61492480
43Rough bone trabeculation (HP:0100670)2.56255200
44CNS hypomyelination (HP:0003429)2.56026161
45Progressive muscle weakness (HP:0003323)2.52396360
46Horseshoe kidney (HP:0000085)2.51910160
47Degeneration of anterior horn cells (HP:0002398)2.49802663
48Abnormality of the anterior horn cell (HP:0006802)2.49802663
49Neoplasm of striated muscle (HP:0009728)2.48326986
50Bone marrow hypocellularity (HP:0005528)2.47237419
51Selective tooth agenesis (HP:0001592)2.46901596
52Chronic diarrhea (HP:0002028)2.45205802
53Respiratory difficulties (HP:0002880)2.43466205
54Sparse lateral eyebrow (HP:0005338)2.42644433
55Termporal pattern (HP:0011008)2.42044015
56Insidious onset (HP:0003587)2.42044015
57Absent thumb (HP:0009777)2.41625465
58Deviation of the thumb (HP:0009603)2.41073706
59Cholelithiasis (HP:0001081)2.40356220
60Vertebral compression fractures (HP:0002953)2.38499485
61Abnormality of lateral ventricle (HP:0030047)2.37252849
62Thrombocytosis (HP:0001894)2.36948834
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.35488100
64Loss of speech (HP:0002371)2.34431328
65Hypokinesia (HP:0002375)2.33277069
66Orthostatic hypotension (HP:0001278)2.32836546
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32139079
68Abnormality of alanine metabolism (HP:0010916)2.32139079
69Hyperalaninemia (HP:0003348)2.32139079
70Microvesicular hepatic steatosis (HP:0001414)2.31104496
71Acute lymphatic leukemia (HP:0006721)2.30371702
72Ectopic kidney (HP:0000086)2.30180079
73Cafe-au-lait spot (HP:0000957)2.29670165
74Abnormality of the carotid arteries (HP:0005344)2.29649586
75Entropion (HP:0000621)2.25192446
76Sloping forehead (HP:0000340)2.23933596
77Recurrent abscess formation (HP:0002722)2.19609904
78Azoospermia (HP:0000027)2.19505498
79Micronodular cirrhosis (HP:0001413)2.18509648
80Absent radius (HP:0003974)2.17446946
81Osteolytic defects of the hand bones (HP:0009699)2.16533367
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.16533367
83Abnormality of the duodenum (HP:0002246)2.16325635
84Fatigue (HP:0012378)2.15094419
85Chronic mucocutaneous candidiasis (HP:0002728)2.14315529
86Recurrent cutaneous fungal infections (HP:0011370)2.14315529
87Absent forearm bone (HP:0003953)2.14100186
88Aplasia involving forearm bones (HP:0009822)2.14100186
89Gastrointestinal inflammation (HP:0004386)2.13279859
90Colon cancer (HP:0003003)2.12886514
91Colitis (HP:0002583)2.12834155
92Clubbing of toes (HP:0100760)2.12556135
93Lower limb hyperreflexia (HP:0002395)2.11536297
94Neoplasm of the pancreas (HP:0002894)2.10961563
95Short nail (HP:0001799)2.09272361
96Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08900890
97Abnormality of the fingertips (HP:0001211)2.07544943
98IgM deficiency (HP:0002850)2.06635077
99Neoplasm of the oral cavity (HP:0100649)2.06539885
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04277926
101Reticulocytopenia (HP:0001896)2.02764285
102Recurrent fungal infections (HP:0002841)2.02447731
103Unsteady gait (HP:0002317)2.01972829
104Squamous cell carcinoma (HP:0002860)2.01893658
105Increased nuchal translucency (HP:0010880)2.01116021
106High anterior hairline (HP:0009890)2.00551275
107Short thumb (HP:0009778)2.00348927
108Broad alveolar ridges (HP:0000187)1.99156755
109Abnormal gallbladder morphology (HP:0012437)1.99063910
110Facial hemangioma (HP:0000329)1.98799679
111Reticulocytosis (HP:0001923)1.98738388
112Microglossia (HP:0000171)1.97460949
113Abnormality of macrophages (HP:0004311)1.97303665
114Short palpebral fissure (HP:0012745)1.97196815
115Oligodactyly (hands) (HP:0001180)1.97145251
116Type I transferrin isoform profile (HP:0003642)1.96752763
117Natal tooth (HP:0000695)1.96614395
118Recurrent bacterial skin infections (HP:0005406)1.96518167
119Panhypogammaglobulinemia (HP:0003139)1.95629086
120Hepatosplenomegaly (HP:0001433)1.95348908
121Shawl scrotum (HP:0000049)1.94315051
122Abnormality of oral frenula (HP:0000190)1.94217699
123Hypoplasia of the pons (HP:0012110)1.94076403
124Slow saccadic eye movements (HP:0000514)1.93851193
125Inflammation of the large intestine (HP:0002037)1.92911710
126Deep philtrum (HP:0002002)1.92564968
127Supernumerary spleens (HP:0009799)1.92539582
128Combined immunodeficiency (HP:0005387)1.91806423
129Pendular nystagmus (HP:0012043)1.91659959
130Eczematoid dermatitis (HP:0000976)1.91468616
131Poikiloderma (HP:0001029)1.91177135
132Asymmetry of the thorax (HP:0001555)1.90627466
133Premature graying of hair (HP:0002216)1.89399375
134Delusions (HP:0000746)1.88059555
135Trismus (HP:0000211)1.87690987
136Oligodactyly (HP:0012165)1.87361430
137Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86968915
138Abnormal protein N-linked glycosylation (HP:0012347)1.86968915
139Abnormal protein glycosylation (HP:0012346)1.86968915
140Abnormal glycosylation (HP:0012345)1.86968915
141Rhabdomyolysis (HP:0003201)1.86966231
142Horizontal nystagmus (HP:0000666)1.86070298
143Long palpebral fissure (HP:0000637)1.85597845
144Progressive hearing impairment (HP:0001730)1.85326262
145Abnormality of T cell physiology (HP:0011840)1.85155384
146Upper limb muscle weakness (HP:0003484)1.84860026
147Trigonocephaly (HP:0000243)1.84538877
148Breast aplasia (HP:0100783)1.83644442
149Septate vagina (HP:0001153)1.82885753
150Abnormality of the lower motor neuron (HP:0002366)1.81458828
151Meningitis (HP:0001287)1.81108888
152Atrophy/Degeneration involving motor neurons (HP:0007373)1.79564128
153Viral hepatitis (HP:0006562)1.79367761
154Triphalangeal thumb (HP:0001199)1.78787838
155Abnormal number of erythroid precursors (HP:0012131)1.77487144
156Increased IgE level (HP:0003212)1.77039025
157Hypoplasia of the radius (HP:0002984)1.76547546
158Aplasia/Hypoplasia of the thymus (HP:0010515)1.76225721
159Capillary hemangiomas (HP:0005306)1.76040642
160Abnormality of glycolipid metabolism (HP:0010969)1.76036930
161Abnormality of liposaccharide metabolism (HP:0010968)1.76036930
162Abnormality of glycosphingolipid metabolism (HP:0004343)1.76036930
163Hypertensive crisis (HP:0100735)1.75961206
164Arteriovenous malformation (HP:0100026)1.75441768
165Petechiae (HP:0000967)1.75090271
166Neoplasm of the colon (HP:0100273)1.74738098
167Cutis marmorata (HP:0000965)1.74399514
168Prominent nose (HP:0000448)1.73433992
169Overlapping toe (HP:0001845)1.73390591
170Abnormality of the intervertebral disk (HP:0005108)1.73020615
171Abnormality of the gallbladder (HP:0005264)1.72857894
172Granulocytopenia (HP:0001913)1.72795561
173Autoimmune hemolytic anemia (HP:0001890)1.72441311
174Pancytopenia (HP:0001876)1.71896848
175Centrally nucleated skeletal muscle fibers (HP:0003687)1.71590248
176Hyperacusis (HP:0010780)1.69578487
177Flat acetabular roof (HP:0003180)1.69226256
178Abnormality of DNA repair (HP:0003254)1.69176423
179Increased serum pyruvate (HP:0003542)1.67488507
180Multiple enchondromatosis (HP:0005701)1.66715615
181Cellulitis (HP:0100658)1.66078586
182Abnormality of T cells (HP:0002843)1.65959671
183Hand muscle atrophy (HP:0009130)1.65239327
184Hepatitis (HP:0012115)1.64175681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K5.42610848
2MAPKAPK34.16796177
3BUB14.14513338
4EIF2AK13.51087649
5NEK23.09039965
6CDC73.05068244
7WEE13.00865072
8PRPF4B2.86112277
9SMG12.81606430
10TTK2.65122083
11TSSK62.63576240
12NME22.59523012
13NEK92.35887330
14IRAK32.28681507
15PLK42.24066344
16TRIB32.23965091
17NEK12.22927846
18PASK2.10361378
19DYRK32.04904124
20RPS6KB22.01035350
21PLK11.99771548
22MST1R1.98589637
23ERN11.85947835
24ACVR1B1.85119014
25BRSK21.83099322
26ICK1.76209587
27PLK31.66989054
28CCNB11.54959292
29SRPK11.44544768
30LATS21.44213571
31BRAF1.42715363
32BRSK11.40376681
33MAP3K131.36562773
34CHEK21.33638266
35ATR1.33589824
36MAP3K141.30893735
37VRK21.30878512
38TESK21.28297867
39MAPK131.28196708
40AURKB1.27895908
41STK161.25446106
42SIK31.23398459
43TESK11.23290342
44RPS6KA41.23120761
45VRK11.20944645
46AURKA1.19087478
47CLK11.17876340
48JAK31.16350601
49BCKDK1.15668989
50PBK1.13912309
51TLK11.12092166
52RIPK41.11966440
53MAP2K31.11379068
54STK101.11088285
55CDK71.10904479
56STK38L1.05743675
57MET1.04384340
58SCYL21.02777435
59MAPKAPK51.01664204
60MAP3K61.00752231
61CDK61.00521063
62TAOK20.97552851
63TYK20.96631683
64CDK40.96407858
65MAP3K80.94492645
66CHEK10.93708748
67DYRK20.93449239
68KSR10.93405063
69CSF1R0.93206878
70MAP4K10.92541875
71PIM20.91510506
72MAPK110.89718879
73SIK10.88012422
74RAF10.86507046
75MARK30.85355259
76STK30.84974740
77DAPK10.82118411
78EIF2AK30.81479756
79MUSK0.80182047
80LATS10.76535677
81MKNK10.76476600
82FGFR40.76266336
83BRD40.75325612
84MOS0.74461804
85FGR0.74289812
86CDK80.74276555
87AKT30.73790129
88CDK90.73220068
89MKNK20.70704034
90CDK20.67229323
91TAOK10.66791971
92TBK10.66491436
93BLK0.66105976
94MAPKAPK20.64962683
95BMPR20.64731324
96PKN20.64472739
97CSNK1G30.64228193
98TTN0.62056137
99ATM0.60357496
100PAK40.60131619
101JAK20.59725932
102IRAK40.59669769
103ILK0.58249643
104YES10.57426882
105STK240.56958292
106MAP3K30.56400270
107MAP3K90.55515488
108KSR20.54838997
109TRPM70.54281604
110PAK60.53499997
111ARAF0.52956282
112CSNK1G10.52852223
113TAOK30.52159248
114CDK10.52143530
115LRRK20.51901942
116TGFBR10.50476026
117PAK10.48233837
118PDPK10.48137751
119FLT30.47947891
120PTK60.46658779
121CDK120.46350915
122MAP3K100.46325920
123RPS6KA20.46323761
124BMX0.45441837
125CDK30.44334789
126EPHA20.43932865
127CDK190.42890585
128KIT0.41349497
129RPS6KB10.40751143
130JAK10.40730818
131MAP3K20.39806452
132PDK10.39607160
133RET0.38687033
134MAP2K70.37863672
135ERBB40.37792087
136CAMKK10.37385423
137CSNK1G20.36569304
138AKT20.35966529
139MTOR0.34053371
140KDR0.33535368
141PRKCI0.32127901
142PDK40.31424936
143PDK30.31424936
144CSNK2A20.30211213
145CSNK2A10.29888691
146STK40.27612793
147PRKAA10.27446054
148MAP3K40.25505461
149MAPK90.23996116
150PRKD30.23781524
151ZAK0.23159287

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.01268443
2Mismatch repair_Homo sapiens_hsa034304.10982866
3RNA polymerase_Homo sapiens_hsa030203.74218098
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.72817081
5Cell cycle_Homo sapiens_hsa041103.23136878
6RNA transport_Homo sapiens_hsa030133.15345824
7Spliceosome_Homo sapiens_hsa030403.08778515
8Base excision repair_Homo sapiens_hsa034103.02889511
9Vitamin B6 metabolism_Homo sapiens_hsa007502.85986447
10Homologous recombination_Homo sapiens_hsa034402.72505371
11Nucleotide excision repair_Homo sapiens_hsa034202.55751294
12Pyrimidine metabolism_Homo sapiens_hsa002402.52411242
13Fanconi anemia pathway_Homo sapiens_hsa034602.39414614
14Basal transcription factors_Homo sapiens_hsa030222.36747304
15One carbon pool by folate_Homo sapiens_hsa006702.32891677
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27968466
17RNA degradation_Homo sapiens_hsa030182.24437350
18Proteasome_Homo sapiens_hsa030502.12467413
19Non-homologous end-joining_Homo sapiens_hsa034501.86146835
20Ribosome_Homo sapiens_hsa030101.81385989
21mRNA surveillance pathway_Homo sapiens_hsa030151.77529331
22Purine metabolism_Homo sapiens_hsa002301.73054791
23p53 signaling pathway_Homo sapiens_hsa041151.69139299
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.68366744
25Biosynthesis of amino acids_Homo sapiens_hsa012301.56238005
26Oocyte meiosis_Homo sapiens_hsa041141.47603969
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46840864
28Measles_Homo sapiens_hsa051621.46079998
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.40457924
30Other glycan degradation_Homo sapiens_hsa005111.39883027
31B cell receptor signaling pathway_Homo sapiens_hsa046621.34567981
32Selenocompound metabolism_Homo sapiens_hsa004501.32768583
33Regulation of autophagy_Homo sapiens_hsa041401.30904169
34Pentose phosphate pathway_Homo sapiens_hsa000301.30437352
35Folate biosynthesis_Homo sapiens_hsa007901.28491778
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23927424
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22124331
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20592822
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18920163
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16926122
41Influenza A_Homo sapiens_hsa051641.13564787
42Shigellosis_Homo sapiens_hsa051311.11675474
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.07851672
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04045846
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03632440
46Epstein-Barr virus infection_Homo sapiens_hsa051691.03320906
47Legionellosis_Homo sapiens_hsa051341.02958772
48Bladder cancer_Homo sapiens_hsa052190.98297930
49Sulfur relay system_Homo sapiens_hsa041220.95297217
50Circadian rhythm_Homo sapiens_hsa047100.94485318
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.93120045
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88509911
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83411894
54Osteoclast differentiation_Homo sapiens_hsa043800.82590176
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80929858
56T cell receptor signaling pathway_Homo sapiens_hsa046600.80781956
57Hepatitis C_Homo sapiens_hsa051600.78826913
58Lysosome_Homo sapiens_hsa041420.74543652
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74543314
60Viral myocarditis_Homo sapiens_hsa054160.73157590
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.72805219
62Carbon metabolism_Homo sapiens_hsa012000.72103877
63Insulin signaling pathway_Homo sapiens_hsa049100.70847933
64Leishmaniasis_Homo sapiens_hsa051400.70789287
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70282256
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68787675
67Renal cell carcinoma_Homo sapiens_hsa052110.66394474
68Galactose metabolism_Homo sapiens_hsa000520.65652336
69Herpes simplex infection_Homo sapiens_hsa051680.65343372
70Tuberculosis_Homo sapiens_hsa051520.63885797
71HTLV-I infection_Homo sapiens_hsa051660.62539036
72Endocytosis_Homo sapiens_hsa041440.61439708
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60731407
74Fructose and mannose metabolism_Homo sapiens_hsa000510.58029379
75Viral carcinogenesis_Homo sapiens_hsa052030.55532468
76Systemic lupus erythematosus_Homo sapiens_hsa053220.53637026
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53330500
78Colorectal cancer_Homo sapiens_hsa052100.53129107
79ErbB signaling pathway_Homo sapiens_hsa040120.51336905
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.50570407
81Toxoplasmosis_Homo sapiens_hsa051450.50227265
82VEGF signaling pathway_Homo sapiens_hsa043700.49989701
83Allograft rejection_Homo sapiens_hsa053300.48233338
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46943648
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46523930
86Insulin resistance_Homo sapiens_hsa049310.45910260
87Salmonella infection_Homo sapiens_hsa051320.45851000
88Glioma_Homo sapiens_hsa052140.45407372
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.45340176
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.45143379
91TNF signaling pathway_Homo sapiens_hsa046680.44959749
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43572367
93MicroRNAs in cancer_Homo sapiens_hsa052060.42946767
94Pyruvate metabolism_Homo sapiens_hsa006200.37902336
95Small cell lung cancer_Homo sapiens_hsa052220.36990351
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35472910
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35141711
98Hippo signaling pathway_Homo sapiens_hsa043900.32522577
99Pancreatic cancer_Homo sapiens_hsa052120.32079161
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29687203
101Non-small cell lung cancer_Homo sapiens_hsa052230.29267739
102Notch signaling pathway_Homo sapiens_hsa043300.28663268
103Hepatitis B_Homo sapiens_hsa051610.28022226
104Thyroid cancer_Homo sapiens_hsa052160.27191215
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26273066
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25625239
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.25609499
108Lysine degradation_Homo sapiens_hsa003100.23564685
109mTOR signaling pathway_Homo sapiens_hsa041500.22778843
110Metabolic pathways_Homo sapiens_hsa011000.22692431
111Antigen processing and presentation_Homo sapiens_hsa046120.22570187
112FoxO signaling pathway_Homo sapiens_hsa040680.22396665
113Ovarian steroidogenesis_Homo sapiens_hsa049130.21435605
114Alcoholism_Homo sapiens_hsa050340.20923682
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20101862
116Endometrial cancer_Homo sapiens_hsa052130.20041342
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.19614493
118Apoptosis_Homo sapiens_hsa042100.18708083
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17825875
120Chronic myeloid leukemia_Homo sapiens_hsa052200.16764740
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16405834
122Vitamin digestion and absorption_Homo sapiens_hsa049770.15443561
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15162791
124Basal cell carcinoma_Homo sapiens_hsa052170.13759083
125Arginine and proline metabolism_Homo sapiens_hsa003300.13457474
126Primary immunodeficiency_Homo sapiens_hsa053400.13128805
127Arginine biosynthesis_Homo sapiens_hsa002200.11984729
128Prostate cancer_Homo sapiens_hsa052150.10590525
129N-Glycan biosynthesis_Homo sapiens_hsa005100.10227876
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.10188762
131Glutathione metabolism_Homo sapiens_hsa004800.08761689
132AMPK signaling pathway_Homo sapiens_hsa041520.07279044
133Hedgehog signaling pathway_Homo sapiens_hsa043400.07169056
134Pathways in cancer_Homo sapiens_hsa052000.06840440
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.04069556
136Linoleic acid metabolism_Homo sapiens_hsa005910.03257454
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.01810222
138Acute myeloid leukemia_Homo sapiens_hsa052210.01575647
139Prolactin signaling pathway_Homo sapiens_hsa049170.00492418

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