GLI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)5.81099477
2regulation of B cell receptor signaling pathway (GO:0050855)5.41362348
3planar cell polarity pathway involved in neural tube closure (GO:0090179)5.15884890
4head development (GO:0060322)5.04607951
5protein heterotrimerization (GO:0070208)5.02201442
6paraxial mesoderm development (GO:0048339)4.96421950
7lateral sprouting from an epithelium (GO:0060601)4.95152265
8polarized epithelial cell differentiation (GO:0030859)4.92373830
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.82785186
10regulation of helicase activity (GO:0051095)4.77260519
11cell proliferation involved in metanephros development (GO:0072203)4.69569730
12establishment of apical/basal cell polarity (GO:0035089)4.59617298
13DNA topological change (GO:0006265)4.55596427
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.46786489
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.46786489
16modulation by symbiont of host immune response (GO:0052553)4.46786489
17positive regulation by symbiont of host defense response (GO:0052509)4.46786489
18modulation by symbiont of host defense response (GO:0052031)4.46786489
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.46786489
20bone trabecula formation (GO:0060346)4.42208740
21negative regulation of phagocytosis (GO:0050765)4.31314773
22outer ear morphogenesis (GO:0042473)4.17996431
23negative regulation of cell killing (GO:0031342)4.06235705
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.06235705
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.05453600
26lung-associated mesenchyme development (GO:0060484)4.03362887
27detection of molecule of bacterial origin (GO:0032490)3.97993346
28regulation of gene silencing by RNA (GO:0060966)3.95040181
29regulation of posttranscriptional gene silencing (GO:0060147)3.95040181
30regulation of gene silencing by miRNA (GO:0060964)3.95040181
31G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.90732121
32establishment of monopolar cell polarity (GO:0061162)3.87601349
33establishment or maintenance of monopolar cell polarity (GO:0061339)3.87601349
34regulation of hair follicle development (GO:0051797)3.79654970
35positive regulation of gamma-delta T cell activation (GO:0046645)3.78603402
36natural killer cell activation involved in immune response (GO:0002323)3.77124995
37regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.73118813
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71615564
39monoubiquitinated protein deubiquitination (GO:0035520)3.68869725
40muscle cell fate commitment (GO:0042693)3.66967028
41cell proliferation involved in kidney development (GO:0072111)3.66716715
42renal system development (GO:0072001)3.65307009
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.62238951
44* anatomical structure regression (GO:0060033)3.59340420
45hair cycle (GO:0042633)3.57652283
46molting cycle (GO:0042303)3.57652283
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.55045258
48mesenchymal cell proliferation (GO:0010463)3.49901792
49positive regulation of Cdc42 GTPase activity (GO:0043089)3.49318642
50non-canonical Wnt signaling pathway (GO:0035567)3.47696831
51hindlimb morphogenesis (GO:0035137)3.45640950
52embryonic skeletal joint morphogenesis (GO:0060272)3.41573400
53eyelid development in camera-type eye (GO:0061029)3.41288346
54Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.39692867
55positive regulation of myotube differentiation (GO:0010831)3.38334224
56macrophage activation involved in immune response (GO:0002281)3.36868703
57B cell receptor signaling pathway (GO:0050853)3.35357446
58generation of neurons (GO:0048699)3.34927880
59detection of other organism (GO:0098543)3.34773898
60detection of biotic stimulus (GO:0009595)3.34667496
61negative regulation of chondrocyte differentiation (GO:0032331)3.33967980
62detection of external biotic stimulus (GO:0098581)3.33099768
63pre-miRNA processing (GO:0031054)3.32288940
64craniofacial suture morphogenesis (GO:0097094)3.31458722
65nuclear pore organization (GO:0006999)3.27651460
66regulation of establishment of planar polarity (GO:0090175)3.27205744
67regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.27168753
68regulation of interferon-beta biosynthetic process (GO:0045357)3.26941213
69nuclear pore complex assembly (GO:0051292)3.25613284
70negative regulation of DNA repair (GO:0045738)3.24727803
71hemidesmosome assembly (GO:0031581)3.22591422
72DNA unwinding involved in DNA replication (GO:0006268)3.20794464
73embryonic hindlimb morphogenesis (GO:0035116)3.19696570
74cochlea morphogenesis (GO:0090103)3.18793179
75cellular extravasation (GO:0045123)3.18501449
76regulation of Cdc42 GTPase activity (GO:0043088)3.11433959
77positive regulation of SMAD protein import into nucleus (GO:0060391)3.10921246
78negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07267832
79positive regulation of hair follicle development (GO:0051798)3.06182582
80positive regulation of hair cycle (GO:0042635)3.06182582
81cardiovascular system development (GO:0072358)3.04911768
82convergent extension (GO:0060026)3.04409528
83respiratory tube development (GO:0030323)3.03570792
84negative regulation of cartilage development (GO:0061037)3.03134212
85negative regulation of smoothened signaling pathway (GO:0045879)3.02269004
86negative regulation of B cell proliferation (GO:0030889)3.02042975
87negative regulation of glial cell proliferation (GO:0060253)3.01954987
88respiratory burst (GO:0045730)3.01635512
89mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.99988817
90somatic stem cell division (GO:0048103)2.99817755
91positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.98841358
92* proximal/distal pattern formation (GO:0009954)2.98472489
93protein localization to kinetochore (GO:0034501)2.97794538
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.97752313
95regulation of hippo signaling (GO:0035330)2.96882463
96detection of bacterium (GO:0016045)2.96804942
97establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.96603093
98leukocyte migration involved in inflammatory response (GO:0002523)2.96488384
99cellular response to exogenous dsRNA (GO:0071360)2.94353600
1003-UTR-mediated mRNA stabilization (GO:0070935)2.94225043
101regulation of gamma-delta T cell activation (GO:0046643)2.93961799
102hippo signaling (GO:0035329)2.93741947
103regulation of gamma-delta T cell differentiation (GO:0045586)2.93714047
104leukocyte aggregation (GO:0070486)2.91444101
105response to interleukin-15 (GO:0070672)2.91224032
106leukocyte degranulation (GO:0043299)2.90817709
107regulation of hair cycle (GO:0042634)2.90721844
108establishment of tissue polarity (GO:0007164)2.89878193
109establishment of planar polarity (GO:0001736)2.89878193
110DNA replication-dependent nucleosome organization (GO:0034723)2.89639628
111DNA replication-dependent nucleosome assembly (GO:0006335)2.89639628
112negative regulation of toll-like receptor signaling pathway (GO:0034122)2.87259450
113extracellular fibril organization (GO:0043206)2.86515867
114regulation of interleukin-12 biosynthetic process (GO:0045075)2.86169914
115fructose metabolic process (GO:0006000)2.86117785
116regulation of SMAD protein import into nucleus (GO:0060390)2.85267870
117regulation of sister chromatid cohesion (GO:0007063)2.83557060
118negative regulation of cell fate specification (GO:0009996)2.83269000
119mRNA transcription from RNA polymerase II promoter (GO:0042789)2.81992249
120negative regulation of catenin import into nucleus (GO:0035414)2.81985684
121negative regulation of defense response to virus (GO:0050687)2.80793988
122cranial suture morphogenesis (GO:0060363)2.80123873
123positive thymic T cell selection (GO:0045059)2.79969674
124collagen metabolic process (GO:0032963)2.79423412
125collagen catabolic process (GO:0030574)2.78240288
126histone H3-K9 demethylation (GO:0033169)2.78146107
127response to host (GO:0075136)2.77245930
128response to host defenses (GO:0052200)2.77245930
129response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77245930
130antigen processing and presentation of endogenous antigen (GO:0019883)2.76838537
131gonadal mesoderm development (GO:0007506)2.76711233
132collagen fibril organization (GO:0030199)2.74979925
133response to host immune response (GO:0052572)2.74110496
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.74110496
135regulation of glial cell proliferation (GO:0060251)2.73515666
136regulation of regulated secretory pathway (GO:1903305)2.73029872
137embryonic foregut morphogenesis (GO:0048617)2.72872190
138histone lysine demethylation (GO:0070076)2.72807202
139regulation of B cell differentiation (GO:0045577)2.72090017
140mesenchyme development (GO:0060485)2.68987909
141heart morphogenesis (GO:0003007)2.67228771
142anterior/posterior axis specification, embryo (GO:0008595)2.66064194
143positive regulation of regulated secretory pathway (GO:1903307)2.65861370
144positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64498084
145histone H3-K9 modification (GO:0061647)2.64342978
146regulation of catenin import into nucleus (GO:0035412)2.64244503
147embryonic camera-type eye development (GO:0031076)2.63938921
148negative regulation of embryonic development (GO:0045992)2.63668446
149regulation of heart morphogenesis (GO:2000826)2.63616323
150negative regulation of mRNA processing (GO:0050686)2.63507167
151peptidyl-arginine omega-N-methylation (GO:0035247)2.62729376
152endodermal cell differentiation (GO:0035987)2.62641747
153skeletal muscle fiber development (GO:0048741)2.62017097
154negative regulation of RNA splicing (GO:0033119)2.61427145
155multicellular organismal macromolecule metabolic process (GO:0044259)2.60004352
156histone demethylation (GO:0016577)2.59351743
157notochord development (GO:0030903)2.58080484
158regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57191697
159antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.57073968
160mRNA transcription (GO:0009299)2.55755861
161positive regulation of gastrulation (GO:2000543)2.55276424
162dorsal/ventral axis specification (GO:0009950)2.54741998
163negative regulation of myotube differentiation (GO:0010832)2.54645049
164midgut development (GO:0007494)2.54048058
165microglial cell activation (GO:0001774)2.54006405
166cell surface receptor signaling pathway involved in heart development (GO:0061311)2.53976347
167regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.53072509
168neural tube closure (GO:0001843)2.52293783
169negative regulation of cell size (GO:0045792)2.51976473
170regulation of cell fate specification (GO:0042659)2.51958672
171embryonic cranial skeleton morphogenesis (GO:0048701)2.51841119
172tube closure (GO:0060606)2.51613012
173multicellular organismal catabolic process (GO:0044243)2.51165959
174RNA stabilization (GO:0043489)2.50579351
175mRNA stabilization (GO:0048255)2.50579351
176regulation of gastrulation (GO:0010470)2.49719735
177cellular hyperosmotic response (GO:0071474)2.49492554
178response to peptidoglycan (GO:0032494)2.48796243
179glucocorticoid receptor signaling pathway (GO:0042921)2.48457778
180heterochromatin organization (GO:0070828)2.48296605
181negative regulation of histone methylation (GO:0031061)2.47934123
182establishment of epithelial cell polarity (GO:0090162)2.47630411
183regulation of macrophage cytokine production (GO:0010935)2.47409223
184branching involved in salivary gland morphogenesis (GO:0060445)2.45868173
185myoblast migration (GO:0051451)2.45022322
186macrophage activation (GO:0042116)2.44156273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.77668690
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.02940754
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.65663187
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.65025524
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.65025524
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.65025524
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.20584143
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.97097638
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.86184522
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67594851
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.50145532
12VDR_21846776_ChIP-Seq_THP-1_Human2.46056122
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.42769319
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.42562437
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42517856
16* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.41199133
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.39891411
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.37165795
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30150716
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29870795
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23669018
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.23630746
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.22149734
24* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.19513578
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17044706
26TCF3_18692474_ChIP-Seq_MEFs_Mouse2.16956497
27VDR_24763502_ChIP-Seq_THP-1_Human2.14562715
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14433770
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12936139
30* MAF_26560356_Chip-Seq_TH1_Human2.12725084
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11945541
32UTX_26944678_Chip-Seq_JUKART_Human2.11163460
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10018552
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.03606313
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02387557
36* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.01147769
37* MYC_22102868_ChIP-Seq_BL_Human2.00352337
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98919017
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98098811
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91721179
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.85520126
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84582308
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82126681
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.78162642
45* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.76138704
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.75855565
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74836315
48SPI1_23547873_ChIP-Seq_NB4_Human1.74184833
49* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74069106
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.73983131
51TCF3_18692474_ChIP-Seq_MESCs_Mouse1.73915653
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71672802
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71192707
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69085366
55* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68396889
56* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66315745
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65945520
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65785729
59* MAF_26560356_Chip-Seq_TH2_Human1.65400797
60MYB_26560356_Chip-Seq_TH1_Human1.65379484
61AR_21909140_ChIP-Seq_LNCAP_Human1.64781890
62MYB_26560356_Chip-Seq_TH2_Human1.61906730
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.61212054
64ZNF263_19887448_ChIP-Seq_K562_Human1.60941400
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.60418436
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.60142267
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.57864587
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57529378
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54947454
70* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52379096
71* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52193210
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51152031
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49874110
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.49646069
75NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.49133246
76* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46981697
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.43885842
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.42944503
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41757606
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38281709
81* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35750552
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34782711
83* KDM2B_26808549_Chip-Seq_DND41_Human1.34542571
84* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32551052
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.32178721
86CLOCK_20551151_ChIP-Seq_293T_Human1.31381508
87POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30094436
88* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27865551
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27327114
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26010694
91XRN2_22483619_ChIP-Seq_HELA_Human1.25676330
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23207283
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.22974566
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22398541
95TCF7_22412390_ChIP-Seq_EML_Mouse1.22202999
96SPI1_23127762_ChIP-Seq_K562_Human1.22189879
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19329146
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18951407
99* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.18066366
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17695973
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17107490
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.16807951
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16756194
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16361629
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15448181
106TP53_20018659_ChIP-ChIP_R1E_Mouse1.15430312
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15369759
108* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15120608
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14641338
110* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14473092
111* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14340494
112SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14262998
113KDM2B_26808549_Chip-Seq_K562_Human1.13980052
114PU_27001747_Chip-Seq_BMDM_Mouse1.13672955
115* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12870689
116SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12666034
117SCL_19346495_ChIP-Seq_HPC-7_Human1.11833658
118* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11145961
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11114259
120GATA1_19941827_ChIP-Seq_MEL_Mouse1.09761560
121RUNX_20019798_ChIP-Seq_JUKART_Human1.09715588
122CIITA_25753668_ChIP-Seq_RAJI_Human1.07066909
123GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07046492
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06593851
125LXR_22292898_ChIP-Seq_THP-1_Human1.06421671
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05269072
127* ISL1_27105846_Chip-Seq_CPCs_Mouse1.04252448
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03830212
129TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03728471
130* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03149718
131TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02721360
132RACK7_27058665_Chip-Seq_MCF-7_Human1.02238572
133* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00425164
134SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00273771
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.99125107
136NCOR1_26117541_ChIP-Seq_K562_Human0.98791530
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98789933
138DROSHA_22980978_ChIP-Seq_HELA_Human0.98645905
139NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98574954
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98011275
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97016416
142MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96764386
143RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96638527
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96406516
145* SA1_27219007_Chip-Seq_ERYTHROID_Human0.95732501
146STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95005189
147* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93644614
148PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93499880
149NANOG_18692474_ChIP-Seq_MESCs_Mouse0.92707975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.87448406
2MP0008438_abnormal_cutaneous_collagen3.61833245
3MP0008260_abnormal_autophagy3.45785391
4MP0010030_abnormal_orbit_morphology3.42859927
5MP0005275_abnormal_skin_tensile3.17376107
6MP0003705_abnormal_hypodermis_morpholog3.14526536
7MP0005503_abnormal_tendon_morphology2.92479770
8MP0002396_abnormal_hematopoietic_system2.77002100
9MP0002254_reproductive_system_inflammat2.57746571
10MP0005084_abnormal_gallbladder_morpholo2.55330469
11MP0000537_abnormal_urethra_morphology2.54232064
12MP0009053_abnormal_anal_canal2.52616564
13MP0003123_paternal_imprinting2.52287577
14MP0009278_abnormal_bone_marrow2.49441592
15MP0001346_abnormal_lacrimal_gland2.40452278
16MP0000579_abnormal_nail_morphology2.29351852
17MP0003303_peritoneal_inflammation2.18284666
18MP0004272_abnormal_basement_membrane2.16440090
19MP0002249_abnormal_larynx_morphology2.09931630
20MP0003436_decreased_susceptibility_to2.09873446
21MP0003385_abnormal_body_wall2.07247337
22MP0005076_abnormal_cell_differentiation2.02860080
23MP0002928_abnormal_bile_duct2.01892026
24MP0003122_maternal_imprinting2.01358310
25MP0003724_increased_susceptibility_to1.99744193
26MP0006054_spinal_hemorrhage1.96926978
27MP0003941_abnormal_skin_development1.96834979
28MP0000428_abnormal_craniofacial_morphol1.96281828
29MP0001243_abnormal_dermal_layer1.89638957
30MP0004808_abnormal_hematopoietic_stem1.88095537
31MP0000049_abnormal_middle_ear1.87249254
32MP0000762_abnormal_tongue_morphology1.86651405
33MP0001835_abnormal_antigen_presentation1.85796642
34MP0002938_white_spotting1.85247393
35MP0009672_abnormal_birth_weight1.83120886
36MP0003252_abnormal_bile_duct1.82353271
37MP0005187_abnormal_penis_morphology1.78704102
38MP0003115_abnormal_respiratory_system1.73373837
39MP0002419_abnormal_innate_immunity1.71922483
40MP0009250_abnormal_appendicular_skeleto1.71703030
41MP0002932_abnormal_joint_morphology1.69938601
42MP0003763_abnormal_thymus_physiology1.65456130
43MP0001800_abnormal_humoral_immune1.65408176
44MP0000858_altered_metastatic_potential1.65328498
45MP0002282_abnormal_trachea_morphology1.65255690
46MP0002060_abnormal_skin_morphology1.65199019
47MP0003937_abnormal_limbs/digits/tail_de1.64841111
48MP0002277_abnormal_respiratory_mucosa1.64112243
49MP0004197_abnormal_fetal_growth/weight/1.63649498
50MP0003755_abnormal_palate_morphology1.63471149
51MP0005451_abnormal_body_composition1.62914521
52MP0003942_abnormal_urinary_system1.62579779
53MP0001849_ear_inflammation1.59670948
54MP0002398_abnormal_bone_marrow1.59398241
55MP0003283_abnormal_digestive_organ1.58149860
56MP0010234_abnormal_vibrissa_follicle1.58144410
57MP0000534_abnormal_ureter_morphology1.57756159
58MP0003935_abnormal_craniofacial_develop1.57089784
59MP0000703_abnormal_thymus_morphology1.57029200
60MP0002653_abnormal_ependyma_morphology1.56180900
61MP0003121_genomic_imprinting1.55455648
62MP0005623_abnormal_meninges_morphology1.54292901
63MP0001293_anophthalmia1.52931355
64MP0003119_abnormal_digestive_system1.51412922
65MP0000733_abnormal_muscle_development1.50876329
66MP0003111_abnormal_nucleus_morphology1.49546412
67MP0005508_abnormal_skeleton_morphology1.47160144
68MP0000432_abnormal_head_morphology1.46494461
69MP0000750_abnormal_muscle_regeneration1.44702229
70MP0001958_emphysema1.44473477
71MP0000490_abnormal_crypts_of1.43081094
72MP0004858_abnormal_nervous_system1.42541527
73MP0002420_abnormal_adaptive_immunity1.40734891
74MP0001819_abnormal_immune_cell1.40597871
75MP0002111_abnormal_tail_morphology1.38908133
76MP0005377_hearing/vestibular/ear_phenot1.38549886
77MP0003878_abnormal_ear_physiology1.38549886
78MP0002116_abnormal_craniofacial_bone1.37840719
79* MP0002085_abnormal_embryonic_tissue1.36884430
80MP0004957_abnormal_blastocyst_morpholog1.36325784
81MP0002452_abnormal_antigen_presenting1.35163787
82MP0002722_abnormal_immune_system1.34486352
83MP0004134_abnormal_chest_morphology1.31867645
84MP0002084_abnormal_developmental_patter1.31448374
85MP0002723_abnormal_immune_serum1.30906795
86MP0000383_abnormal_hair_follicle1.30804003
87MP0000647_abnormal_sebaceous_gland1.27931659
88MP0002405_respiratory_system_inflammati1.26791238
89MP0001299_abnormal_eye_distance/1.26714629
90MP0010094_abnormal_chromosome_stability1.26394941
91MP0000716_abnormal_immune_system1.25668780
92MP0005000_abnormal_immune_tolerance1.25284009
93MP0004381_abnormal_hair_follicle1.25136391
94MP0002429_abnormal_blood_cell1.24745820
95MP0005387_immune_system_phenotype1.24668693
96MP0001790_abnormal_immune_system1.24668693
97MP0000689_abnormal_spleen_morphology1.23894982
98MP0008932_abnormal_embryonic_tissue1.23313396
99MP0000566_synostosis1.22857516
100MP0003567_abnormal_fetal_cardiomyocyte1.19309199
101MP0002108_abnormal_muscle_morphology1.18842867
102MP0000467_abnormal_esophagus_morphology1.18398365
103MP0004947_skin_inflammation1.18002160
104* MP0002109_abnormal_limb_morphology1.17078072
105MP0005025_abnormal_response_to1.16203822
106MP0005257_abnormal_intraocular_pressure1.16181037
107MP0002114_abnormal_axial_skeleton1.15936897
108MP0000685_abnormal_immune_system1.15681386
109MP0003077_abnormal_cell_cycle1.15034678
110MP0003315_abnormal_perineum_morphology1.14944408
111MP0005310_abnormal_salivary_gland1.13898816
112MP0009333_abnormal_splenocyte_physiolog1.13253945
113MP0002233_abnormal_nose_morphology1.13215240
114MP0003279_aneurysm1.12305821
115MP0004883_abnormal_blood_vessel1.12131120
116MP0005220_abnormal_exocrine_pancreas1.11815537
117MP0002098_abnormal_vibrissa_morphology1.11651651
118MP0010307_abnormal_tumor_latency1.10933930
119MP0010678_abnormal_skin_adnexa1.09642845
120MP0002896_abnormal_bone_mineralization1.09352699
121MP0001340_abnormal_eyelid_morphology1.09203448
122MP0002132_abnormal_respiratory_system1.08299465
123MP0010352_gastrointestinal_tract_polyps1.06593932
124* MP0000350_abnormal_cell_proliferation1.04463218
125MP0002166_altered_tumor_susceptibility1.03954571
126MP0005380_embryogenesis_phenotype1.03573006
127MP0001672_abnormal_embryogenesis/_devel1.03573006
128MP0005367_renal/urinary_system_phenotyp1.03112474
129MP0000516_abnormal_urinary_system1.03112474
130MP0002092_abnormal_eye_morphology1.03024621
131MP0002697_abnormal_eye_size1.02387611
132MP0003448_altered_tumor_morphology1.02325289
133MP0002115_abnormal_skeleton_extremities1.02101953
134MP0005408_hypopigmentation1.01972648
135MP0005248_abnormal_Harderian_gland1.00882108
136MP0002089_abnormal_postnatal_growth/wei1.00451171
137MP0004185_abnormal_adipocyte_glucose1.00205373
138MP0002086_abnormal_extraembryonic_tissu1.00149976
139MP0001730_embryonic_growth_arrest0.99894552
140MP0004133_heterotaxia0.99767233
141MP0001697_abnormal_embryo_size0.99490667
142MP0008057_abnormal_DNA_replication0.97925663
143MP0000377_abnormal_hair_follicle0.97912360
144MP0003566_abnormal_cell_adhesion0.96965083
145MP0001533_abnormal_skeleton_physiology0.96936302
146MP0002088_abnormal_embryonic_growth/wei0.93692837
147MP0000163_abnormal_cartilage_morphology0.92640029
148MP0003828_pulmonary_edema0.91960020
149MP0003300_gastrointestinal_ulcer0.91935478
150MP0003984_embryonic_growth_retardation0.91931071
151MP0001286_abnormal_eye_development0.90822470
152MP0003693_abnormal_embryo_hatching0.90744801
153MP0009703_decreased_birth_body0.90193278
154* MP0003861_abnormal_nervous_system0.87993765
155MP0001915_intracranial_hemorrhage0.87901669
156MP0001216_abnormal_epidermal_layer0.87537834
157MP0002925_abnormal_cardiovascular_devel0.85956896
158MP0008995_early_reproductive_senescence0.85772429
159MP0005671_abnormal_response_to0.82992948
160MP0000767_abnormal_smooth_muscle0.80949230
161MP0005464_abnormal_platelet_physiology0.80899235
162* MP0002019_abnormal_tumor_incidence0.79886381
163MP0005388_respiratory_system_phenotype0.79576994
164MP0002133_abnormal_respiratory_system0.79576994
165MP0003221_abnormal_cardiomyocyte_apopto0.79046163

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)6.76935808
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)6.76935808
3Abnormality of the 4th metacarpal (HP:0010012)5.18519710
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.76121585
5Abnormality of the parietal bone (HP:0002696)4.67686292
6Milia (HP:0001056)4.60957798
7Alveolar cell carcinoma (HP:0006519)4.41433909
8Neoplasm of the heart (HP:0100544)4.24629650
9Neoplasm of the tracheobronchial system (HP:0100552)4.22064149
10Ankle contracture (HP:0006466)4.12461785
11Atrophic scars (HP:0001075)3.80866350
12Supernumerary ribs (HP:0005815)3.77010730
13Medulloblastoma (HP:0002885)3.68403872
14Shallow orbits (HP:0000586)3.55158127
15Eczematoid dermatitis (HP:0000976)3.49059390
16Supernumerary bones of the axial skeleton (HP:0009144)3.45778101
17Down-sloping shoulders (HP:0200021)3.44072821
18Short phalanx of the thumb (HP:0009660)3.43906630
19Neoplasm of the oral cavity (HP:0100649)3.40240018
20Renal duplication (HP:0000075)3.34946443
21Follicular hyperkeratosis (HP:0007502)3.27979474
22Selective tooth agenesis (HP:0001592)3.18862076
23Gingivitis (HP:0000230)3.18226820
24Abnormality of the distal phalanx of the thumb (HP:0009617)3.16300491
25Protrusio acetabuli (HP:0003179)3.11393527
26Bladder diverticulum (HP:0000015)3.09951384
27Recurrent bacterial skin infections (HP:0005406)3.08295927
28Abnormal number of incisors (HP:0011064)3.04043726
29Type 1 muscle fiber predominance (HP:0003803)3.02622509
30Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.02443860
31Renovascular hypertension (HP:0100817)3.02044037
32Premature rupture of membranes (HP:0001788)2.92124322
33Recurrent abscess formation (HP:0002722)2.90110346
34Chest pain (HP:0100749)2.84410164
35Persistence of primary teeth (HP:0006335)2.83592556
36Meningitis (HP:0001287)2.80568773
37Abnormality of the diencephalon (HP:0010662)2.80385254
38Bronchomalacia (HP:0002780)2.78104646
39Abnormality of the fingertips (HP:0001211)2.74408334
40Pulmonary infiltrates (HP:0002113)2.71496808
41Broad metatarsal (HP:0001783)2.70901987
42Fragile skin (HP:0001030)2.70192849
43Midline defect of the nose (HP:0004122)2.69408180
44Spinal cord lesions (HP:0100561)2.67799730
45Syringomyelia (HP:0003396)2.67799730
46Slender build (HP:0001533)2.66882372
47Neoplasm of striated muscle (HP:0009728)2.60696726
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.60625420
49Hyperacusis (HP:0010780)2.58678909
50Overriding aorta (HP:0002623)2.50507105
51Trigonocephaly (HP:0000243)2.48708537
52Orchitis (HP:0100796)2.47595012
53T lymphocytopenia (HP:0005403)2.44977725
54Deformed sella turcica (HP:0002681)2.43353370
55Abnormality of the astrocytes (HP:0100707)2.40960297
56Astrocytoma (HP:0009592)2.40960297
57Myositis (HP:0100614)2.40789857
58Cerebral aneurysm (HP:0004944)2.39295150
59Emphysema (HP:0002097)2.38830259
60Gastrointestinal infarctions (HP:0005244)2.33944635
61Increased connective tissue (HP:0009025)2.33253769
62Hemivertebrae (HP:0002937)2.30837010
63Bowel diverticulosis (HP:0005222)2.29314536
64Flat cornea (HP:0007720)2.28206856
65Abnormal ossification of hand bones (HP:0005921)2.25621123
66Neonatal short-limb short stature (HP:0008921)2.25595505
67Lymphangioma (HP:0100764)2.22157185
68Retrobulbar optic neuritis (HP:0100654)2.21892533
69Optic neuritis (HP:0100653)2.21892533
70Elfin facies (HP:0004428)2.21359568
71Aortic dissection (HP:0002647)2.20767059
72Elevated erythrocyte sedimentation rate (HP:0003565)2.19814584
73Abnormality of T cells (HP:0002843)2.18040507
74Ankyloglossia (HP:0010296)2.17770747
75Basal cell carcinoma (HP:0002671)2.14617499
76Abnormality of T cell number (HP:0011839)2.14319333
77Slow saccadic eye movements (HP:0000514)2.14047292
78Deviation of the hallux (HP:0010051)2.12467560
79Cellulitis (HP:0100658)2.11411147
80Spinal rigidity (HP:0003306)2.11019567
81Neoplasm of the respiratory system (HP:0100606)2.10044633
82Hemoptysis (HP:0002105)2.09936969
83Large earlobe (HP:0009748)2.09130985
84Recurrent skin infections (HP:0001581)2.08698993
85Soft skin (HP:0000977)2.08364543
86Sex reversal (HP:0012245)2.07893930
87Abnormal sex determination (HP:0012244)2.07893930
88Recurrent fungal infections (HP:0002841)2.05160951
89Abnormality of the labia majora (HP:0012881)2.04639318
90Mitral valve prolapse (HP:0001634)2.04206172
91Mildly elevated creatine phosphokinase (HP:0008180)2.03944220
92Premature graying of hair (HP:0002216)2.02630128
93Hallux valgus (HP:0001822)2.01025866
94Tracheomalacia (HP:0002779)2.01018764
95Vitreoretinal degeneration (HP:0000655)2.00292445
96Recurrent gram-negative bacterial infections (HP:0005420)1.99499975
97Abnormal hand bone ossification (HP:0010660)1.98188566
98Chronic mucocutaneous candidiasis (HP:0002728)1.97980937
99Recurrent cutaneous fungal infections (HP:0011370)1.97980937
100Coronal craniosynostosis (HP:0004440)1.97860352
101Skin tags (HP:0010609)1.97352631
102Increased nuchal translucency (HP:0010880)1.97088886
103Neoplasm of the lung (HP:0100526)1.96092078
104Mesomelia (HP:0003027)1.95797430
105Broad toe (HP:0001837)1.95329174
106Fibroma (HP:0010614)1.95274160
107Hypoplastic labia majora (HP:0000059)1.93963168
108Metaphyseal cupping (HP:0003021)1.93482198
109Abnormality of the sella turcica (HP:0002679)1.93386579
110Abnormality of incisor morphology (HP:0011063)1.92434482
111Fibrous tissue neoplasm (HP:0012316)1.90845168
112Increased variability in muscle fiber diameter (HP:0003557)1.90241448
113Thin ribs (HP:0000883)1.90137745
114Calcaneovalgus deformity (HP:0001848)1.90016469
115Stomatitis (HP:0010280)1.89821676
116Arterial tortuosity (HP:0005116)1.89726344
117Abnormality of T cell physiology (HP:0011840)1.89669591
118Ectopia lentis (HP:0001083)1.88880468
119Spontaneous hematomas (HP:0007420)1.88306651
120Genu recurvatum (HP:0002816)1.88218235
121Ependymoma (HP:0002888)1.87755428
122Abnormality of the incisor (HP:0000676)1.87277666
123Gastrointestinal carcinoma (HP:0002672)1.86840832
124Malignant gastrointestinal tract tumors (HP:0006749)1.86840832
125Partial duplication of the phalanx of hand (HP:0009999)1.84388171
126Choroideremia (HP:0001139)1.83712266
127Restrictive lung disease (HP:0002091)1.83231017
128Lymphopenia (HP:0001888)1.83066669
129Vertebral fusion (HP:0002948)1.82742148
130Skull defect (HP:0001362)1.81439488
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.81387972
132Abnormality of the peritoneum (HP:0002585)1.81330256
133Turricephaly (HP:0000262)1.81315851
134Adenoma sebaceum (HP:0009720)1.80418860
135Angiofibromas (HP:0010615)1.80418860
136Increased IgE level (HP:0003212)1.80236604
137Hypotrichosis (HP:0001006)1.79715584
138Atresia of the external auditory canal (HP:0000413)1.79592008
139Abnormality of macrophages (HP:0004311)1.78875681
140Abnormality of the calcaneus (HP:0008364)1.78383775
141Dislocated radial head (HP:0003083)1.78341864
142Glioma (HP:0009733)1.77048244
143Renal cell carcinoma (HP:0005584)1.76853570
144Insomnia (HP:0100785)1.76677627
145Ulnar bowing (HP:0003031)1.76620156
146Mediastinal lymphadenopathy (HP:0100721)1.75448594
147Broad thumb (HP:0011304)1.75422574
148Absent frontal sinuses (HP:0002688)1.74839697
149Long eyelashes (HP:0000527)1.74809072
150Protruding ear (HP:0000411)1.74789030
151Dilatation of the ascending aorta (HP:0005111)1.74677704
152Abnormality of oral frenula (HP:0000190)1.74273581
153Sprengel anomaly (HP:0000912)1.73877998
154Abnormality of the pleura (HP:0002103)1.73500549
155Obstructive lung disease (HP:0006536)1.72190297
156Chronic obstructive pulmonary disease (HP:0006510)1.72190297
157Hemangiomatosis (HP:0007461)1.71522780
158Esophageal atresia (HP:0002032)1.71401508
159Hypoplasia of the maxilla (HP:0000327)1.71274712
160Sparse lateral eyebrow (HP:0005338)1.69948844
161Abnormality of the labia minora (HP:0012880)1.69182187
162Skin pits (HP:0100276)1.68416816
163Bilateral microphthalmos (HP:0007633)1.65430053
164Broad hallux (HP:0010055)1.65195313
165Peritonitis (HP:0002586)1.62344146
166Broad face (HP:0000283)1.61139908
167Broad long bones (HP:0005622)1.61092408
168Intestinal polyp (HP:0005266)1.60952856
169Anophthalmia (HP:0000528)1.60565288
170Arnold-Chiari malformation (HP:0002308)1.59670145
171Joint laxity (HP:0001388)1.59313754
172Abnormality of skeletal muscle fiber size (HP:0012084)1.59061509
173Short ribs (HP:0000773)1.58967821
174Rectal prolapse (HP:0002035)1.58589279
175Depressed nasal tip (HP:0000437)1.56674030
176Absent eyelashes (HP:0000561)1.55337726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF14.71972005
2MOS3.41004272
3CDK123.32401248
4MAP3K103.24436911
5PASK3.05373222
6LATS13.02195265
7SMG12.95896287
8EEF2K2.76011029
9BLK2.73079666
10PKN22.58947305
11RIPK42.57957301
12PRPF4B2.52135791
13TRIB32.50278778
14YES12.47757096
15RIPK12.47024749
16CDC72.39834297
17DDR22.39704039
18SIK12.36317149
19LATS22.26971823
20PDGFRA2.25679796
21IRAK42.17323170
22JAK32.12844058
23TTN2.09976314
24MAP4K12.07453959
25NEK22.01085176
26STK242.00924260
27EPHB21.96410263
28TLK11.91478649
29RPS6KB21.87746530
30BRD41.75136737
31TTK1.73917852
32EPHA21.72600872
33CDK71.72543296
34MAP2K31.72076644
35ICK1.70170529
36FGFR11.69339764
37GRK61.66482255
38CSK1.65732121
39FGFR21.61234485
40PAK41.60351913
41MAP3K51.54248924
42BMX1.52156068
43SIK31.48272772
44PTK61.46844796
45SRPK11.43936150
46CDK41.39977697
47PAK21.37059380
48MTOR1.36649585
49MET1.35377265
50FGR1.34241750
51WEE11.31714969
52MKNK11.28336539
53EPHB11.24273763
54TGFBR11.17176391
55ALK1.13010274
56MARK21.12521536
57TYK21.12286997
58TSSK61.10068198
59BTK1.09343456
60CDK61.09076854
61MKNK21.06729128
62MAP3K11.04271278
63STK31.03035615
64PIK3CG1.02594119
65ATR1.02493218
66NEK11.02199755
67FES1.02113573
68ITK1.00069544
69HCK0.97036321
70MAP3K80.96161699
71BUB10.94156370
72CHEK10.93487922
73TYRO30.91664291
74PLK10.91496130
75STK40.91490391
76CHEK20.91339929
77CLK10.89862884
78KSR20.89498323
79MAP3K30.89477891
80DMPK0.89205982
81MATK0.88598423
82AURKB0.87887613
83PIM10.85694003
84IRAK20.82508035
85IKBKE0.82334359
86NLK0.81639407
87CDK20.77128503
88DYRK30.76444439
89TAOK10.75744977
90ZAP700.75663342
91WNK10.75197268
92CAMK40.75143366
93FER0.74940297
94TAOK20.73761109
95LYN0.72210142
96ILK0.71539370
97ATM0.71334706
98PTK20.69795743
99SYK0.69146416
100LRRK20.68694068
101TEC0.68498673
102RPS6KA60.67532132
103TNK20.67496246
104PDGFRB0.66184328
105MELK0.63956934
106SIK20.63827817
107CDK10.63119561
108ERBB20.62640020
109FGFR40.62350732
110FGFR30.60938384
111DYRK1A0.60745744
112AKT20.59962954
113FLT30.59712368
114MAPK10.58684948
115CAMK1D0.57181560
116VRK20.56712039
117IRAK10.55844598
118CSNK1E0.55442745
119CSNK1D0.54679309
120STK38L0.53582059
121RPS6KA40.53161155
122MARK30.53114589
123PLK30.52360490
124MAPK140.51472514
125PRKDC0.50847827
126RPS6KA20.50058554
127SGK30.49053716
128PAK10.48886780
129PBK0.46581807
130AKT10.46163026
131PRKD20.46130053
132JAK20.45858846
133MAP3K140.45773340
134CDK190.45701700
135MAPKAPK20.44841464
136TXK0.44171466
137ZAK0.44016579
138PNCK0.43152994
139MAP3K70.42585063
140CAMK1G0.42506050
141AURKA0.42483194
142RPS6KA10.41340144
143KSR10.40721910
144MAPK80.40311213
145ERN10.40227733
146STK110.39801545
147GSK3B0.39692531
148LCK0.39585974
149GRK50.37898852
150ROCK10.36971238
151PRKD30.36438058
152CHUK0.35244675
153ROCK20.34330551
154CDC42BPA0.33614494
155DYRK1B0.32129241
156RPS6KC10.32042647
157RPS6KL10.32042647
158GSK3A0.30587511
159MAPKAPK30.29922915
160CDK90.29845306
161MAPK90.29782479

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052174.77489932
2* Hedgehog signaling pathway_Homo sapiens_hsa043403.91693977
3ECM-receptor interaction_Homo sapiens_hsa045122.73246148
4Hippo signaling pathway_Homo sapiens_hsa043902.48567153
5Protein digestion and absorption_Homo sapiens_hsa049742.44521879
6Spliceosome_Homo sapiens_hsa030402.42010387
7Notch signaling pathway_Homo sapiens_hsa043302.37156500
8Mismatch repair_Homo sapiens_hsa034302.29583800
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.28454051
10DNA replication_Homo sapiens_hsa030302.25924660
11Leishmaniasis_Homo sapiens_hsa051402.16692221
12RNA transport_Homo sapiens_hsa030132.06120973
13B cell receptor signaling pathway_Homo sapiens_hsa046622.05674447
14Cell cycle_Homo sapiens_hsa041101.97936672
15mRNA surveillance pathway_Homo sapiens_hsa030151.95366851
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91606886
17Osteoclast differentiation_Homo sapiens_hsa043801.91424373
18Systemic lupus erythematosus_Homo sapiens_hsa053221.87004165
19Proteoglycans in cancer_Homo sapiens_hsa052051.78883979
20Wnt signaling pathway_Homo sapiens_hsa043101.75349644
21MicroRNAs in cancer_Homo sapiens_hsa052061.74636458
22Small cell lung cancer_Homo sapiens_hsa052221.71301511
23TGF-beta signaling pathway_Homo sapiens_hsa043501.68110595
24Focal adhesion_Homo sapiens_hsa045101.67616524
25One carbon pool by folate_Homo sapiens_hsa006701.58380455
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58126337
27Fructose and mannose metabolism_Homo sapiens_hsa000511.53387886
28Adherens junction_Homo sapiens_hsa045201.52680681
29Ribosome_Homo sapiens_hsa030101.50700815
30Primary immunodeficiency_Homo sapiens_hsa053401.47360038
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46861824
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.45608109
33* Pathways in cancer_Homo sapiens_hsa052001.43324757
34Measles_Homo sapiens_hsa051621.43291737
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43094472
36Selenocompound metabolism_Homo sapiens_hsa004501.39255927
37HTLV-I infection_Homo sapiens_hsa051661.38077167
38Base excision repair_Homo sapiens_hsa034101.35275894
39Melanogenesis_Homo sapiens_hsa049161.33868109
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.33786770
41Lysine degradation_Homo sapiens_hsa003101.33342145
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30703077
43T cell receptor signaling pathway_Homo sapiens_hsa046601.30651124
44Malaria_Homo sapiens_hsa051441.29765845
45Colorectal cancer_Homo sapiens_hsa052101.25820855
46Alcoholism_Homo sapiens_hsa050341.22058980
47Amoebiasis_Homo sapiens_hsa051461.21213621
48Staphylococcus aureus infection_Homo sapiens_hsa051501.21111453
49Tuberculosis_Homo sapiens_hsa051521.20645136
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19881797
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18923592
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18867729
53Nucleotide excision repair_Homo sapiens_hsa034201.14484336
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14451323
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13238849
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11916909
57Viral carcinogenesis_Homo sapiens_hsa052031.11209535
58Bladder cancer_Homo sapiens_hsa052191.09742089
59p53 signaling pathway_Homo sapiens_hsa041151.09525507
60Chemokine signaling pathway_Homo sapiens_hsa040621.09248336
61Influenza A_Homo sapiens_hsa051641.07788360
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07619500
63Galactose metabolism_Homo sapiens_hsa000521.07065695
64Axon guidance_Homo sapiens_hsa043601.06587402
65Central carbon metabolism in cancer_Homo sapiens_hsa052301.05027489
66PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04676969
67Fanconi anemia pathway_Homo sapiens_hsa034601.04499330
68Chronic myeloid leukemia_Homo sapiens_hsa052201.04303486
69Prostate cancer_Homo sapiens_hsa052151.02784865
70Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01972448
71Endometrial cancer_Homo sapiens_hsa052131.01611692
72mTOR signaling pathway_Homo sapiens_hsa041500.99347949
73RNA degradation_Homo sapiens_hsa030180.98039759
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97264596
75Hepatitis C_Homo sapiens_hsa051600.94657117
76Tight junction_Homo sapiens_hsa045300.94348858
77Thyroid cancer_Homo sapiens_hsa052160.94306688
78Oocyte meiosis_Homo sapiens_hsa041140.93084858
79Homologous recombination_Homo sapiens_hsa034400.91509672
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91381431
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.91024975
82Inositol phosphate metabolism_Homo sapiens_hsa005620.89948951
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89713961
84Melanoma_Homo sapiens_hsa052180.88628497
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87849046
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.85554661
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84836616
88Viral myocarditis_Homo sapiens_hsa054160.82737399
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77638037
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77015236
91Prolactin signaling pathway_Homo sapiens_hsa049170.76943368
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75513471
93African trypanosomiasis_Homo sapiens_hsa051430.74285536
94Hematopoietic cell lineage_Homo sapiens_hsa046400.73918917
95Estrogen signaling pathway_Homo sapiens_hsa049150.71874575
96Dorso-ventral axis formation_Homo sapiens_hsa043200.69842022
97Choline metabolism in cancer_Homo sapiens_hsa052310.69839688
98Graft-versus-host disease_Homo sapiens_hsa053320.69336232
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67847556
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66156005
101Glioma_Homo sapiens_hsa052140.64045330
102TNF signaling pathway_Homo sapiens_hsa046680.62194744
103Non-small cell lung cancer_Homo sapiens_hsa052230.61490681
104Rap1 signaling pathway_Homo sapiens_hsa040150.60837611
105Autoimmune thyroid disease_Homo sapiens_hsa053200.59996153
106Herpes simplex infection_Homo sapiens_hsa051680.59990220
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.57210351
108Allograft rejection_Homo sapiens_hsa053300.56325320
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56128261
110Dilated cardiomyopathy_Homo sapiens_hsa054140.55343175
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54038779
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53937940
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53583409
114Toxoplasmosis_Homo sapiens_hsa051450.51555863
115Acute myeloid leukemia_Homo sapiens_hsa052210.50212395
116Insulin resistance_Homo sapiens_hsa049310.48271792
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48054618
118Gap junction_Homo sapiens_hsa045400.46618514
119Epstein-Barr virus infection_Homo sapiens_hsa051690.45015894
120Renal cell carcinoma_Homo sapiens_hsa052110.44489937
121VEGF signaling pathway_Homo sapiens_hsa043700.42190824
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41945088
123Basal transcription factors_Homo sapiens_hsa030220.40944798
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40449146
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.40291426
126Pancreatic cancer_Homo sapiens_hsa052120.39954793
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.38555305
128Platelet activation_Homo sapiens_hsa046110.36960664
129Hepatitis B_Homo sapiens_hsa051610.36361028
130MAPK signaling pathway_Homo sapiens_hsa040100.35966519
131AMPK signaling pathway_Homo sapiens_hsa041520.35683524
132ErbB signaling pathway_Homo sapiens_hsa040120.35388365
133FoxO signaling pathway_Homo sapiens_hsa040680.34050551
134Apoptosis_Homo sapiens_hsa042100.33824933
135GnRH signaling pathway_Homo sapiens_hsa049120.32713665
136RNA polymerase_Homo sapiens_hsa030200.31946494
137Type II diabetes mellitus_Homo sapiens_hsa049300.31000091
138Insulin signaling pathway_Homo sapiens_hsa049100.30767722
139Antigen processing and presentation_Homo sapiens_hsa046120.30186874
140Non-homologous end-joining_Homo sapiens_hsa034500.27705258
141HIF-1 signaling pathway_Homo sapiens_hsa040660.27049385

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