GLI4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)5.71269922
2negative regulation of erythrocyte differentiation (GO:0045647)5.48752845
3GDP-mannose metabolic process (GO:0019673)4.84594233
4positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.71054286
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.03147192
6semaphorin-plexin signaling pathway (GO:0071526)4.02421113
7negative regulation of cell size (GO:0045792)4.00175044
8regulation of ARF GTPase activity (GO:0032312)3.86557813
9proline biosynthetic process (GO:0006561)3.81955288
10response to muramyl dipeptide (GO:0032495)3.49256985
11histone H4 deacetylation (GO:0070933)3.42912528
12positive regulation of histone deacetylation (GO:0031065)3.39618865
13adenosine receptor signaling pathway (GO:0001973)3.38900002
14thymic T cell selection (GO:0045061)3.36686060
15positive thymic T cell selection (GO:0045059)3.36096018
16positive regulation of protein deacetylation (GO:0090312)3.30961986
17response to peptidoglycan (GO:0032494)3.30742877
18UV protection (GO:0009650)3.30254234
19negative regulation of granulocyte differentiation (GO:0030853)3.29616139
20apoptotic process involved in morphogenesis (GO:0060561)3.25658198
21regulation of type I interferon-mediated signaling pathway (GO:0060338)3.24539746
22positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.21683608
23activation of Rac GTPase activity (GO:0032863)3.18680208
24modulation by virus of host process (GO:0019054)3.18494058
25regulation of hydrogen peroxide metabolic process (GO:0010310)3.17274963
26positive regulation of protein kinase C signaling (GO:0090037)3.12676678
27activation of JUN kinase activity (GO:0007257)3.10576002
28positive regulation of gamma-delta T cell activation (GO:0046645)3.06281244
29snRNA metabolic process (GO:0016073)3.02738322
30phosphatidylglycerol biosynthetic process (GO:0006655)3.00865094
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99055716
32negative regulation of viral release from host cell (GO:1902187)2.97226647
33protein retention in ER lumen (GO:0006621)2.96571550
34intracellular estrogen receptor signaling pathway (GO:0030520)2.94940109
35negative regulation of interleukin-8 production (GO:0032717)2.92559238
36histone H3 deacetylation (GO:0070932)2.88962777
37cellular response to virus (GO:0098586)2.88032486
38antigen processing and presentation of endogenous antigen (GO:0019883)2.87101509
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85458497
40negative regulation of cell killing (GO:0031342)2.85458497
41regulation of interferon-beta biosynthetic process (GO:0045357)2.83323393
42modulation by symbiont of host cellular process (GO:0044068)2.80402183
43regulation of monocyte differentiation (GO:0045655)2.79908666
44proline metabolic process (GO:0006560)2.79212293
45negative regulation of tumor necrosis factor production (GO:0032720)2.79174310
46pyrimidine nucleoside salvage (GO:0043097)2.78055066
47pyrimidine-containing compound salvage (GO:0008655)2.78055066
48G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77997502
49response to laminar fluid shear stress (GO:0034616)2.72670855
50regulation of mammary gland epithelial cell proliferation (GO:0033599)2.71907372
51regulation of chromatin binding (GO:0035561)2.71835384
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71801713
53NIK/NF-kappaB signaling (GO:0038061)2.70332118
54positive regulation of CREB transcription factor activity (GO:0032793)2.70295912
55negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.70121730
56T cell selection (GO:0045058)2.69189061
57snRNA processing (GO:0016180)2.68777452
58cell-cell junction maintenance (GO:0045217)2.67380972
59positive regulation of odontogenesis (GO:0042482)2.65977718
60regulation of histone H3-K27 methylation (GO:0061085)2.63741253
61positive regulation of Cdc42 GTPase activity (GO:0043089)2.62859900
62atrioventricular valve morphogenesis (GO:0003181)2.62802230
63detection of bacterium (GO:0016045)2.62398044
64G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.62182731
65cell-substrate adherens junction assembly (GO:0007045)2.59707569
66focal adhesion assembly (GO:0048041)2.59707569
67mitochondrion localization (GO:0051646)2.58990193
68negative regulation of innate immune response (GO:0045824)2.57026700
69poly(A)+ mRNA export from nucleus (GO:0016973)2.56508616
70regulation of cholesterol metabolic process (GO:0090181)2.55424440
71mature B cell differentiation involved in immune response (GO:0002313)2.53849724
72regulation of ARF protein signal transduction (GO:0032012)2.52975193
73retrograde transport, endosome to Golgi (GO:0042147)2.52361616
74regulation of T-helper 2 cell differentiation (GO:0045628)2.52278385
75negative regulation of toll-like receptor signaling pathway (GO:0034122)2.51237780
76negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.50676711
77maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.50644133
78regulation of leukocyte degranulation (GO:0043300)2.49244313
79regulation of gamma-delta T cell activation (GO:0046643)2.47853883
80regulation of cytokine production involved in inflammatory response (GO:1900015)2.45997406
81regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45148227
82mitochondrion distribution (GO:0048311)2.42813836
83germinal center formation (GO:0002467)2.42605369
84maternal placenta development (GO:0001893)2.42377884
853-UTR-mediated mRNA stabilization (GO:0070935)2.42176120
86adherens junction assembly (GO:0034333)2.42045073
87detection of other organism (GO:0098543)2.41467031
88mitochondrion transport along microtubule (GO:0047497)2.41432234
89establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.41432234
90endothelial cell chemotaxis (GO:0035767)2.41406900
91regulation of mast cell degranulation (GO:0043304)2.39754082
92regulation of necroptotic process (GO:0060544)2.39580432
93positive regulation of myotube differentiation (GO:0010831)2.39076407
94peptidyl-glutamic acid carboxylation (GO:0017187)2.38220973
95protein carboxylation (GO:0018214)2.38220973
96regulation of gamma-delta T cell differentiation (GO:0045586)2.37399778
97modulation by symbiont of host defense response (GO:0052031)2.35889093
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35889093
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.35889093
100modulation by symbiont of host immune response (GO:0052553)2.35889093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.80154858
2* LXR_22292898_ChIP-Seq_THP-1_Human3.13710297
3MYC_22102868_ChIP-Seq_BL_Human2.80540400
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.79789795
5* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.63433509
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.56088946
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.55750399
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.42981879
9KDM2B_26808549_Chip-Seq_DND41_Human2.37194879
10P68_20966046_ChIP-Seq_HELA_Human2.32653916
11RACK7_27058665_Chip-Seq_MCF-7_Human2.30963405
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28869270
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28080174
14TCF7_22412390_ChIP-Seq_EML_Mouse2.18664750
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07870886
16MAF_26560356_Chip-Seq_TH2_Human2.03172067
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.00480750
18VDR_24763502_ChIP-Seq_THP-1_Human1.97491318
19ERG_21242973_ChIP-ChIP_JURKAT_Human1.95209488
20MAF_26560356_Chip-Seq_TH1_Human1.92633675
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.89594082
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87256612
23CTCF_27219007_Chip-Seq_ERYTHROID_Human1.85602695
24SA1_27219007_Chip-Seq_ERYTHROID_Human1.79105031
25BCL6_27268052_Chip-Seq_Bcells_Human1.78408624
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78317249
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76660834
28UTX_26944678_Chip-Seq_JUKART_Human1.75713673
29SMC4_20622854_ChIP-Seq_HELA_Human1.75672852
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74835079
31BCOR_27268052_Chip-Seq_Bcells_Human1.74563987
32KDM2B_26808549_Chip-Seq_K562_Human1.70657473
33* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65850587
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65803523
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.65107778
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.60969608
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.57743014
38CREB1_26743006_Chip-Seq_LNCaP_Human1.53578885
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53079536
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.52562876
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50260270
42CTCF_27219007_Chip-Seq_Bcells_Human1.49701875
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49031820
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48320481
45MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.47396102
46PHF8_20622854_ChIP-Seq_HELA_Human1.45298267
47E2F1_20622854_ChIP-Seq_HELA_Human1.45287606
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.44956059
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43160125
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41684797
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41580773
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40292301
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38876309
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34977538
55NCOR1_26117541_ChIP-Seq_K562_Human1.34181957
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34122637
57RARB_24833708_ChIP-Seq_LIVER_Mouse1.32298189
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30999931
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.30831696
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29975849
61CTCF_21964334_ChIP-Seq_BJAB-B_Human1.29526240
62* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28475891
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28445147
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28051371
65CTCF_21964334_Chip-Seq_Bcells_Human1.27777096
66TP53_22127205_ChIP-Seq_IMR90_Human1.26674217
67CTCF_26484167_Chip-Seq_Bcells_Mouse1.25068327
68RARA_24833708_ChIP-Seq_LIVER_Mouse1.24343157
69SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22325610
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20825548
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.18813228
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17379335
73SA1_27219007_Chip-Seq_Bcells_Human1.16177307
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16161702
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16123223
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15603476
77FOXP1_21924763_ChIP-Seq_HESCs_Human1.14365444
78ETS1_21867929_ChIP-Seq_TH2_Mouse1.13948891
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13227389
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.12625401
81SCL_19346495_ChIP-Seq_HPC-7_Human1.11870990
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11663994
83* XRN2_22483619_ChIP-Seq_HELA_Human1.07498894
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07217396
85CIITA_25753668_ChIP-Seq_RAJI_Human1.06760740
86* TP63_22573176_ChIP-Seq_HFKS_Human1.06572717
87ATF3_27146783_Chip-Seq_COLON_Human1.05453012
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04372116
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03601431
90YY1_22570637_ChIP-Seq_MALME-3M_Human1.03558332
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03537340
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02054121
93RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01802451
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01681191
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01583017
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00990865
97CTCF_20526341_ChIP-Seq_ESCs_Human1.00464262
98ZNF263_19887448_ChIP-Seq_K562_Human1.00313276
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99193643
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99164411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.54256492
2MP0003705_abnormal_hypodermis_morpholog3.49338557
3MP0003436_decreased_susceptibility_to3.04722718
4MP0003172_abnormal_lysosome_physiology2.88606092
5MP0009278_abnormal_bone_marrow2.80179931
6MP0008260_abnormal_autophagy2.59102535
7MP0005076_abnormal_cell_differentiation2.56276887
8MP0005171_absent_coat_pigmentation2.47686495
9MP0003303_peritoneal_inflammation2.42315942
10MP0005451_abnormal_body_composition2.35734896
11MP0004381_abnormal_hair_follicle2.21351265
12MP0005083_abnormal_biliary_tract2.18403151
13MP0001986_abnormal_taste_sensitivity2.13882927
14MP0004185_abnormal_adipocyte_glucose2.13431883
15MP0001873_stomach_inflammation2.10029751
16MP0000751_myopathy1.95445307
17MP0005423_abnormal_somatic_nervous1.95147325
18MP0000678_abnormal_parathyroid_gland1.88863016
19MP0005409_darkened_coat_color1.86861306
20MP0001849_ear_inflammation1.85693331
21MP0003453_abnormal_keratinocyte_physiol1.85464522
22MP0004858_abnormal_nervous_system1.77852407
23MP0005666_abnormal_adipose_tissue1.76134100
24MP0003191_abnormal_cellular_cholesterol1.66719075
25MP0003763_abnormal_thymus_physiology1.65641751
26MP0000003_abnormal_adipose_tissue1.64690224
27MP0009333_abnormal_splenocyte_physiolog1.62761396
28MP0002249_abnormal_larynx_morphology1.61850114
29MP0005375_adipose_tissue_phenotype1.56922615
30MP0002396_abnormal_hematopoietic_system1.53401428
31MP0005025_abnormal_response_to1.51048260
32MP0004947_skin_inflammation1.49783402
33MP0009840_abnormal_foam_cell1.49179031
34MP0002933_joint_inflammation1.47565558
35MP0000858_altered_metastatic_potential1.44425072
36MP0001348_abnormal_lacrimal_gland1.43280964
37MP0000685_abnormal_immune_system1.42823581
38MP0002419_abnormal_innate_immunity1.40832273
39MP0005174_abnormal_tail_pigmentation1.39914172
40MP0004130_abnormal_muscle_cell1.33636924
41MP0010155_abnormal_intestine_physiology1.30482896
42MP0005000_abnormal_immune_tolerance1.30401616
43MP0001800_abnormal_humoral_immune1.30118685
44MP0001835_abnormal_antigen_presentation1.30087647
45MP0003279_aneurysm1.26700233
46MP0009384_cardiac_valve_regurgitation1.24471465
47MP0002723_abnormal_immune_serum1.24019490
48MP0002398_abnormal_bone_marrow1.23750838
49MP0002420_abnormal_adaptive_immunity1.21202932
50MP0005387_immune_system_phenotype1.21032392
51MP0001790_abnormal_immune_system1.21032392
52MP0001958_emphysema1.21015191
53MP0001819_abnormal_immune_cell1.20738970
54MP0003091_abnormal_cell_migration1.20315231
55MP0005501_abnormal_skin_physiology1.19483986
56MP0002822_catalepsy1.18371517
57MP0000750_abnormal_muscle_regeneration1.15317553
58MP0000013_abnormal_adipose_tissue1.13933838
59MP0002452_abnormal_antigen_presenting1.13570119
60MP0000716_abnormal_immune_system1.12289538
61MP0001533_abnormal_skeleton_physiology1.09709450
62MP0005397_hematopoietic_system_phenotyp1.07066787
63MP0001545_abnormal_hematopoietic_system1.07066787
64MP0005330_cardiomyopathy1.04887787
65MP0009931_abnormal_skin_appearance1.04618330
66MP0002405_respiratory_system_inflammati1.04097567
67MP0002429_abnormal_blood_cell1.04009841
68MP0001502_abnormal_circadian_rhythm1.03782664
69MP0000703_abnormal_thymus_morphology1.03648435
70MP0004510_myositis1.01005274
71MP0002722_abnormal_immune_system0.98873442
72MP0003300_gastrointestinal_ulcer0.97431062
73MP0000747_muscle_weakness0.97261864
74MP0003724_increased_susceptibility_to0.96773621
75MP0003866_abnormal_defecation0.96402330
76MP0002796_impaired_skin_barrier0.96062895
77MP0003806_abnormal_nucleotide_metabolis0.92881173
78MP0002089_abnormal_postnatal_growth/wei0.92149296
79MP0005670_abnormal_white_adipose0.91298559
80MP0005464_abnormal_platelet_physiology0.90694393
81MP0004808_abnormal_hematopoietic_stem0.89965635
82MP0008874_decreased_physiological_sensi0.89148118
83MP0000689_abnormal_spleen_morphology0.84866917
84MP0000490_abnormal_crypts_of0.82093054
85MP0002970_abnormal_white_adipose0.80022692
86MP0002998_abnormal_bone_remodeling0.79179625
87MP0006082_CNS_inflammation0.78551514
88MP0000759_abnormal_skeletal_muscle0.78485583
89MP0002254_reproductive_system_inflammat0.77212885
90MP0003879_abnormal_hair_cell0.75172818
91MP0001663_abnormal_digestive_system0.75096156
92MP0008469_abnormal_protein_level0.74759654
93MP0000733_abnormal_muscle_development0.74138541
94MP0005671_abnormal_response_to0.74023161
95MP0001845_abnormal_inflammatory_respons0.73497329
96MP0000470_abnormal_stomach_morphology0.71991046
97MP0005360_urolithiasis0.71821877
98MP0002132_abnormal_respiratory_system0.71592844
99MP0000681_abnormal_thyroid_gland0.69888469
100MP0000767_abnormal_smooth_muscle0.67221020

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)4.92510514
2Testicular atrophy (HP:0000029)3.61869125
3Hemorrhage of the eye (HP:0011885)3.60714834
4Obstructive sleep apnea (HP:0002870)3.57161972
5Ulnar bowing (HP:0003031)3.56720350
6Annular pancreas (HP:0001734)3.54074615
7Cervical subluxation (HP:0003308)3.28194367
8Colitis (HP:0002583)3.26737237
9Joint stiffness (HP:0001387)3.25195584
10Broad face (HP:0000283)3.14051178
11Abnormality of mucopolysaccharide metabolism (HP:0011020)3.11192357
12Abnormality of polysaccharide metabolism (HP:0011012)3.11192357
13Abnormality of glycosaminoglycan metabolism (HP:0004371)3.11192357
14Rib fusion (HP:0000902)3.06224325
15Mucopolysacchariduria (HP:0008155)3.02343716
16Urinary glycosaminoglycan excretion (HP:0003541)3.02343716
17Stridor (HP:0010307)2.98528716
18Dysostosis multiplex (HP:0000943)2.92030428
19Turricephaly (HP:0000262)2.79803580
20Gastrointestinal inflammation (HP:0004386)2.75931951
21J-shaped sella turcica (HP:0002680)2.73420929
22Myopathic facies (HP:0002058)2.71534263
23Distal upper limb amyotrophy (HP:0007149)2.62680356
24Upper limb amyotrophy (HP:0009129)2.62680356
25Hyperacusis (HP:0010780)2.48444048
26Abnormality of the thoracic spine (HP:0100711)2.39768021
27Intestinal fistula (HP:0100819)2.39089794
28Eczematoid dermatitis (HP:0000976)2.38522750
29Thoracic kyphosis (HP:0002942)2.37611597
30Easy fatigability (HP:0003388)2.36697423
31Mesangial abnormality (HP:0001966)2.34774257
32Inflammation of the large intestine (HP:0002037)2.33703956
33Increased IgE level (HP:0003212)2.32621481
34Cellulitis (HP:0100658)2.26808466
35Cerebral aneurysm (HP:0004944)2.22944006
36Poikiloderma (HP:0001029)2.19798245
37Abnormality of the fingertips (HP:0001211)2.18187867
38Distal lower limb amyotrophy (HP:0008944)2.15491309
39Loss of speech (HP:0002371)2.15097030
40Biconcave vertebral bodies (HP:0004586)2.13755684
41Long palpebral fissure (HP:0000637)2.12116833
42Hypertriglyceridemia (HP:0002155)2.08423210
43Pustule (HP:0200039)2.07793578
44Thin ribs (HP:0000883)2.07511352
45Hypertensive crisis (HP:0100735)2.07418633
46Vaginal fistula (HP:0004320)2.07310798
47Bulbar palsy (HP:0001283)2.04928828
48Malnutrition (HP:0004395)2.01260192
49Distal lower limb muscle weakness (HP:0009053)2.00585635
50Emphysema (HP:0002097)1.99799191
51Hand muscle atrophy (HP:0009130)1.98257986
52Delayed epiphyseal ossification (HP:0002663)1.97397461
53Pointed chin (HP:0000307)1.97339104
54Increased connective tissue (HP:0009025)1.96513553
55Bowed forearm bones (HP:0003956)1.95964276
56Bowing of the arm (HP:0006488)1.95964276
57Akinesia (HP:0002304)1.94792664
58Nuclear cataract (HP:0100018)1.93892576
59Joint hemorrhage (HP:0005261)1.93888632
60Ragged-red muscle fibers (HP:0003200)1.93427736
61Facial hemangioma (HP:0000329)1.93273460
62Atelectasis (HP:0100750)1.93074110
63Mitral regurgitation (HP:0001653)1.92777513
64Protrusio acetabuli (HP:0003179)1.91927230
65Chronic obstructive pulmonary disease (HP:0006510)1.90981967
66Obstructive lung disease (HP:0006536)1.90981967
67Lymphangioma (HP:0100764)1.89828264
68Dislocated radial head (HP:0003083)1.89568354
69Asymmetric septal hypertrophy (HP:0001670)1.88795962
70Squamous cell carcinoma (HP:0002860)1.88313023
71Increased cerebral lipofuscin (HP:0011813)1.86801701
72Exercise-induced myalgia (HP:0003738)1.85471164
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83898840
74Anteriorly placed anus (HP:0001545)1.83283913
75Seborrheic dermatitis (HP:0001051)1.82610149
76Elevated erythrocyte sedimentation rate (HP:0003565)1.81635800
77Metaphyseal cupping (HP:0003021)1.81157634
78Vertebral compression fractures (HP:0002953)1.80146800
79Rectal fistula (HP:0100590)1.76861114
80Rectovaginal fistula (HP:0000143)1.76861114
81Gastrointestinal infarctions (HP:0005244)1.76492638
82Increased neuronal autofluorescent lipopigment (HP:0002074)1.76173026
83Hypochromic anemia (HP:0001931)1.76035907
84Gastrointestinal dysmotility (HP:0002579)1.75496174
85Achilles tendon contracture (HP:0001771)1.74829809
86Abnormality of the radial head (HP:0003995)1.73975183
87Flat acetabular roof (HP:0003180)1.73397847
88Increased serum ferritin (HP:0003281)1.72496568
89Supernumerary nipples (HP:0002558)1.71383457
90Disproportionate tall stature (HP:0001519)1.71339681
91Recurrent fungal infections (HP:0002841)1.70270051
92Myositis (HP:0100614)1.70062189
93Polygenic inheritance (HP:0010982)1.68133369
94Reticulocytosis (HP:0001923)1.67455606
95Spinal canal stenosis (HP:0003416)1.66461499
96Prolonged bleeding time (HP:0003010)1.64363683
97Panhypogammaglobulinemia (HP:0003139)1.63881942
98Sparse lateral eyebrow (HP:0005338)1.63350043
99Fetal akinesia sequence (HP:0001989)1.63102743
100Hypercortisolism (HP:0001578)1.62301920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.93519301
2PRPF4B3.73221517
3MAPK153.63435176
4ERN13.57578854
5SIK13.34101789
6MAP4K12.56886052
7MAP2K32.40923712
8SIK21.98278935
9TNK21.96746440
10SMG11.94268431
11ICK1.83370152
12TAOK21.74210819
13PKN21.71597818
14BLK1.64912136
15PRKD21.64797179
16EEF2K1.62397395
17GRK61.62069796
18IRAK31.57653617
19MARK21.56354661
20MAP3K131.54473870
21RIPK41.48189355
22TBK11.43562603
23ZAP701.41927208
24CDK121.40829967
25SIK31.33300840
26MAP3K61.30926497
27TESK21.21012630
28EPHB11.18951877
29MAP3K111.14571065
30RIPK11.13827531
31MAP2K61.12424517
32CDC42BPA1.12339482
33PDPK11.09332790
34MAP3K71.08905335
35CSK1.06296742
36RPS6KA21.02319913
37TYK21.02121791
38NME21.00585004
39EPHA21.00469142
40IRAK40.97281135
41PTK60.97076224
42BTK0.96708446
43PRKD30.94278998
44FGFR40.93785929
45TAOK10.92577136
46MAPK120.90680441
47RPS6KC10.90358301
48RPS6KL10.90358301
49TTN0.89816517
50HIPK20.89009561
51ARAF0.88486538
52MTOR0.88023329
53BMX0.86618467
54MAP3K10.86013121
55MAP3K100.84253275
56MAP3K30.80856618
57MST1R0.80791477
58JAK30.78678385
59CAMKK10.77392011
60CDK40.76511255
61RPS6KA60.75513849
62PIM20.73969457
63DYRK1B0.71041940
64IRAK20.71031922
65KSR20.70531332
66KIT0.70079525
67MAPK110.67010111
68TESK10.66694792
69PDK10.65718432
70FES0.64824697
71MAPKAPK30.61124727
72MUSK0.58111329
73HCK0.57918851
74IKBKE0.57001247
75MAP3K140.55535888
76MAPK70.55505423
77CSF1R0.51425379
78PRKD10.49510569
79DDR20.49207413
80PTK20.48320154
81SYK0.47187865
82STK380.45914041
83IKBKB0.45768801
84CDK90.43081074
85RET0.42911892
86FLT30.40323592
87LRRK20.39454057
88PAK40.39222028
89PDGFRA0.38548639
90LCK0.38432877
91ILK0.38247925
92MAPK80.34912337
93MAP2K20.34580888
94MAPKAPK20.33378040
95PRKCH0.32385918
96ITK0.32036907
97KDR0.31072461
98PRKAA10.31058855
99RAF10.29993762
100LYN0.29681651

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.67544596
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.93757661
3Sulfur relay system_Homo sapiens_hsa041222.50673991
4Acute myeloid leukemia_Homo sapiens_hsa052212.41193021
5Notch signaling pathway_Homo sapiens_hsa043302.35674076
6Fructose and mannose metabolism_Homo sapiens_hsa000512.12586776
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.01169687
8VEGF signaling pathway_Homo sapiens_hsa043702.00598240
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.84647724
10B cell receptor signaling pathway_Homo sapiens_hsa046621.81246996
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.78752670
12Chronic myeloid leukemia_Homo sapiens_hsa052201.69209373
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64515990
14Osteoclast differentiation_Homo sapiens_hsa043801.63611858
15mTOR signaling pathway_Homo sapiens_hsa041501.58783885
16Non-small cell lung cancer_Homo sapiens_hsa052231.57455952
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57042352
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42192869
19Neurotrophin signaling pathway_Homo sapiens_hsa047221.36545676
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.36371097
21Leishmaniasis_Homo sapiens_hsa051401.31686157
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30723120
23Bladder cancer_Homo sapiens_hsa052191.26227801
24Lysosome_Homo sapiens_hsa041421.21049089
25Pancreatic cancer_Homo sapiens_hsa052121.17507260
26Phospholipase D signaling pathway_Homo sapiens_hsa040721.14542682
27Insulin signaling pathway_Homo sapiens_hsa049101.12327643
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11414036
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.10747515
30Hepatitis C_Homo sapiens_hsa051601.10571958
31Insulin resistance_Homo sapiens_hsa049311.10025079
32Primary immunodeficiency_Homo sapiens_hsa053401.08950625
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06781101
34Inositol phosphate metabolism_Homo sapiens_hsa005621.06642396
35Lysine degradation_Homo sapiens_hsa003101.06606157
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.06052226
37Tuberculosis_Homo sapiens_hsa051521.01893309
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.00364381
39Endometrial cancer_Homo sapiens_hsa052131.00022417
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99646851
41Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99568211
42Toxoplasmosis_Homo sapiens_hsa051450.99528612
43T cell receptor signaling pathway_Homo sapiens_hsa046600.99114191
44TNF signaling pathway_Homo sapiens_hsa046680.97607072
45ErbB signaling pathway_Homo sapiens_hsa040120.97299597
46Influenza A_Homo sapiens_hsa051640.96522966
47Choline metabolism in cancer_Homo sapiens_hsa052310.96168004
48Endocytosis_Homo sapiens_hsa041440.95852460
49GnRH signaling pathway_Homo sapiens_hsa049120.91221416
50AMPK signaling pathway_Homo sapiens_hsa041520.86930560
51Renal cell carcinoma_Homo sapiens_hsa052110.85660761
52Hepatitis B_Homo sapiens_hsa051610.83505280
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82535729
54Prolactin signaling pathway_Homo sapiens_hsa049170.82519281
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.81669913
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81180788
57Glioma_Homo sapiens_hsa052140.80726032
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80547645
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79892081
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77675724
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.74276566
62HTLV-I infection_Homo sapiens_hsa051660.72349096
63Herpes simplex infection_Homo sapiens_hsa051680.70243221
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68812162
65Platelet activation_Homo sapiens_hsa046110.68437453
66Pentose phosphate pathway_Homo sapiens_hsa000300.68280967
67MAPK signaling pathway_Homo sapiens_hsa040100.65637661
68Apoptosis_Homo sapiens_hsa042100.65311943
69Chemokine signaling pathway_Homo sapiens_hsa040620.64625405
70Prion diseases_Homo sapiens_hsa050200.64204283
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63933439
72Measles_Homo sapiens_hsa051620.63107465
73Staphylococcus aureus infection_Homo sapiens_hsa051500.61790452
74Galactose metabolism_Homo sapiens_hsa000520.60861125
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.60830682
76Malaria_Homo sapiens_hsa051440.60144777
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59900237
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59262835
79Estrogen signaling pathway_Homo sapiens_hsa049150.58775145
80Viral carcinogenesis_Homo sapiens_hsa052030.57586842
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.57141021
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56776995
83Colorectal cancer_Homo sapiens_hsa052100.56735864
84ABC transporters_Homo sapiens_hsa020100.56524292
85Base excision repair_Homo sapiens_hsa034100.55880114
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54665370
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54318585
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50359072
89Shigellosis_Homo sapiens_hsa051310.50110240
90Sphingolipid metabolism_Homo sapiens_hsa006000.49742027
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49612597
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49027401
93Pertussis_Homo sapiens_hsa051330.48686398
94Biosynthesis of amino acids_Homo sapiens_hsa012300.46916379
95Melanogenesis_Homo sapiens_hsa049160.46690425
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45947486
97Epstein-Barr virus infection_Homo sapiens_hsa051690.44919130
98Focal adhesion_Homo sapiens_hsa045100.44725105
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42033961
100Hematopoietic cell lineage_Homo sapiens_hsa046400.41720247

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