

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative regulation of cell killing (GO:0031342) | 5.83976030 |
| 2 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.83976030 |
| 3 | regulation of T-helper 1 cell differentiation (GO:0045625) | 5.41749306 |
| 4 | positive regulation by symbiont of host defense response (GO:0052509) | 5.37239161 |
| 5 | modulation by symbiont of host defense response (GO:0052031) | 5.37239161 |
| 6 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.37239161 |
| 7 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.37239161 |
| 8 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.37239161 |
| 9 | modulation by symbiont of host immune response (GO:0052553) | 5.37239161 |
| 10 | regulation of activation of Janus kinase activity (GO:0010533) | 5.05885758 |
| 11 | detection of other organism (GO:0098543) | 4.99334053 |
| 12 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.75418397 |
| 13 | detection of bacterium (GO:0016045) | 4.71815751 |
| 14 | positive regulation of natural killer cell differentiation (GO:0032825) | 4.68739023 |
| 15 | negative regulation of interleukin-12 production (GO:0032695) | 4.68397512 |
| 16 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.67823471 |
| 17 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.67823471 |
| 18 | macrophage activation involved in immune response (GO:0002281) | 4.66057821 |
| 19 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 4.61374031 |
| 20 | positive regulation of T-helper cell differentiation (GO:0045624) | 4.58525973 |
| 21 | NIK/NF-kappaB signaling (GO:0038061) | 4.54971431 |
| 22 | negative thymic T cell selection (GO:0045060) | 4.53742892 |
| 23 | cellular extravasation (GO:0045123) | 4.53049144 |
| 24 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.49160204 |
| 25 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.38427300 |
| 26 | negative T cell selection (GO:0043383) | 4.35485167 |
| 27 | detection of external biotic stimulus (GO:0098581) | 4.31514678 |
| 28 | detection of molecule of bacterial origin (GO:0032490) | 4.30052311 |
| 29 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 4.26002224 |
| 30 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.06428166 |
| 31 | neutrophil activation involved in immune response (GO:0002283) | 3.96118813 |
| 32 | respiratory burst (GO:0045730) | 3.96036296 |
| 33 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.93437995 |
| 34 | positive regulation of interleukin-12 production (GO:0032735) | 3.93127441 |
| 35 | regulation of gamma-delta T cell activation (GO:0046643) | 3.90932279 |
| 36 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.86689582 |
| 37 | regulation of hypersensitivity (GO:0002883) | 3.84720476 |
| 38 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.83987128 |
| 39 | detection of biotic stimulus (GO:0009595) | 3.83321002 |
| 40 | regulation of T cell tolerance induction (GO:0002664) | 3.81182220 |
| 41 | type I interferon signaling pathway (GO:0060337) | 3.78106203 |
| 42 | cellular response to type I interferon (GO:0071357) | 3.78106203 |
| 43 | microglial cell activation (GO:0001774) | 3.76432646 |
| 44 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.75932897 |
| 45 | regulation of mast cell degranulation (GO:0043304) | 3.75079779 |
| 46 | leukocyte migration involved in inflammatory response (GO:0002523) | 3.74772472 |
| 47 | regulation of memory T cell differentiation (GO:0043380) | 3.74292940 |
| 48 | response to type I interferon (GO:0034340) | 3.73662293 |
| 49 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.73657393 |
| 50 | sequestering of actin monomers (GO:0042989) | 3.71323432 |
| 51 | T-helper 1 type immune response (GO:0042088) | 3.69665452 |
| 52 | myeloid dendritic cell differentiation (GO:0043011) | 3.69638078 |
| 53 | regulation of RIG-I signaling pathway (GO:0039535) | 3.69002482 |
| 54 | cellular response to zinc ion (GO:0071294) | 3.68972248 |
| 55 | response to host immune response (GO:0052572) | 3.68347189 |
| 56 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.68347189 |
| 57 | myeloid cell activation involved in immune response (GO:0002275) | 3.62647583 |
| 58 | regulation of T-helper cell differentiation (GO:0045622) | 3.60998270 |
| 59 | neutrophil activation (GO:0042119) | 3.59767408 |
| 60 | positive regulation of mast cell activation (GO:0033005) | 3.58754104 |
| 61 | positive regulation of antigen processing and presentation (GO:0002579) | 3.58487346 |
| 62 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 3.57666251 |
| 63 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.56049769 |
| 64 | myeloid dendritic cell activation (GO:0001773) | 3.54054672 |
| 65 | regulation of antigen processing and presentation (GO:0002577) | 3.53089369 |
| 66 | macrophage activation (GO:0042116) | 3.52157578 |
| 67 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.51669894 |
| 68 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.49317473 |
| 69 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.46078652 |
| 70 | regulation of T-helper 1 type immune response (GO:0002825) | 3.46067493 |
| 71 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.42200435 |
| 72 | response to host (GO:0075136) | 3.40970629 |
| 73 | response to host defenses (GO:0052200) | 3.40970629 |
| 74 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.40970629 |
| 75 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 3.38684502 |
| 76 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.38139863 |
| 77 | regulation of natural killer cell differentiation (GO:0032823) | 3.38050144 |
| 78 | regulation of mast cell activation (GO:0033003) | 3.37801680 |
| 79 | granulocyte activation (GO:0036230) | 3.37605622 |
| 80 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.36513569 |
| 81 | natural killer cell differentiation (GO:0001779) | 3.35041940 |
| 82 | neutrophil mediated immunity (GO:0002446) | 3.34225015 |
| 83 | dendritic cell chemotaxis (GO:0002407) | 3.33647229 |
| 84 | response to interleukin-15 (GO:0070672) | 3.32330357 |
| 85 | negative regulation of T cell mediated immunity (GO:0002710) | 3.32170961 |
| 86 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.31755155 |
| 87 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.30804073 |
| 88 | regulation of leukocyte degranulation (GO:0043300) | 3.29389128 |
| 89 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 3.29034931 |
| 90 | positive regulation of T cell apoptotic process (GO:0070234) | 3.25788769 |
| 91 | negative regulation of viral genome replication (GO:0045071) | 3.24961685 |
| 92 | regulation of interleukin-12 production (GO:0032655) | 3.24237223 |
| 93 | positive regulation of interleukin-17 production (GO:0032740) | 3.22382738 |
| 94 | natural killer cell mediated immunity (GO:0002228) | 3.22117450 |
| 95 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.22117450 |
| 96 | positive regulation of type 2 immune response (GO:0002830) | 3.22016434 |
| 97 | positive regulation of T-helper 1 type immune response (GO:0002827) | 3.21252006 |
| 98 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.20855880 |
| 99 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.19650691 |
| 100 | positive regulation of mast cell degranulation (GO:0043306) | 3.19650691 |
| 101 | dendritic cell differentiation (GO:0097028) | 3.19332277 |
| 102 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.18928378 |
| 103 | regulation of protein heterodimerization activity (GO:0043497) | 3.18562836 |
| 104 | natural killer cell activation (GO:0030101) | 3.18117848 |
| 105 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.16081193 |
| 106 | positive regulation of interleukin-2 production (GO:0032743) | 3.14371413 |
| 107 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.13353655 |
| 108 | positive regulation of interferon-alpha production (GO:0032727) | 3.13007043 |
| 109 | cellular response to interleukin-15 (GO:0071350) | 3.12754476 |
| 110 | ribosomal small subunit assembly (GO:0000028) | 3.11459945 |
| 111 | positive regulation of tolerance induction (GO:0002645) | 3.10481727 |
| 112 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.09874114 |
| 113 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.09695909 |
| 114 | positive regulation of humoral immune response (GO:0002922) | 3.09321747 |
| 115 | positive regulation of cellular amide metabolic process (GO:0034250) | 3.06483704 |
| 116 | positive regulation of activated T cell proliferation (GO:0042104) | 3.05475584 |
| 117 | leukocyte degranulation (GO:0043299) | 3.05086028 |
| 118 | regulation of tolerance induction (GO:0002643) | 3.03741338 |
| 119 | defense response to protozoan (GO:0042832) | 3.03366040 |
| 120 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.01786847 |
| 121 | germinal center formation (GO:0002467) | 3.00632316 |
| 122 | positive regulation of isotype switching (GO:0045830) | 3.00371377 |
| 123 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.98549862 |
| 124 | thymic T cell selection (GO:0045061) | 2.97438313 |
| 125 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.96780212 |
| 126 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.96182671 |
| 127 | negative regulation of interleukin-6 production (GO:0032715) | 2.95817675 |
| 128 | dendritic cell migration (GO:0036336) | 2.95320468 |
| 129 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 2.95025361 |
| 130 | myeloid leukocyte mediated immunity (GO:0002444) | 2.94838573 |
| 131 | regulation of interferon-alpha production (GO:0032647) | 2.93450111 |
| 132 | positive regulation of pseudopodium assembly (GO:0031274) | 2.93164965 |
| 133 | B cell mediated immunity (GO:0019724) | 2.93163660 |
| 134 | positive regulation of B cell differentiation (GO:0045579) | 2.92720714 |
| 135 | T cell selection (GO:0045058) | 2.91601874 |
| 136 | tolerance induction (GO:0002507) | 2.91205850 |
| 137 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.90500012 |
| 138 | positive regulation of monocyte chemotaxis (GO:0090026) | 2.90406726 |
| 139 | negative regulation of phagocytosis (GO:0050765) | 2.90025100 |
| 140 | regulation of B cell differentiation (GO:0045577) | 2.88334931 |
| 141 | neutrophil chemotaxis (GO:0030593) | 2.87343830 |
| 142 | negative regulation of innate immune response (GO:0045824) | 2.86998310 |
| 143 | response to interferon-beta (GO:0035456) | 2.85860757 |
| 144 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 2.85076656 |
| 145 | myeloid leukocyte activation (GO:0002274) | 2.84363667 |
| 146 | T cell migration (GO:0072678) | 2.84229103 |
| 147 | activated T cell proliferation (GO:0050798) | 2.83592778 |
| 148 | cellular response to interferon-beta (GO:0035458) | 2.83074503 |
| 149 | regulation of regulated secretory pathway (GO:1903305) | 2.81196330 |
| 150 | positive regulation of alpha-beta T cell differentiation (GO:0046638) | 2.81136758 |
| 151 | response to interferon-alpha (GO:0035455) | 2.80880999 |
| 152 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.80658969 |
| 153 | positive thymic T cell selection (GO:0045059) | 2.80109588 |
| 154 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.79996260 |
| 155 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 2.79996260 |
| 156 | neutrophil migration (GO:1990266) | 2.79812312 |
| 157 | leukocyte aggregation (GO:0070486) | 2.77222901 |
| 158 | positive regulation of T cell proliferation (GO:0042102) | 2.77151569 |
| 159 | response to muramyl dipeptide (GO:0032495) | 2.74522347 |
| 160 | positive regulation of lymphocyte apoptotic process (GO:0070230) | 2.74498061 |
| 161 | immunoglobulin mediated immune response (GO:0016064) | 2.74237412 |
| 162 | regulation of immunoglobulin secretion (GO:0051023) | 2.73772229 |
| 163 | negative regulation of interleukin-17 production (GO:0032700) | 2.73321632 |
| 164 | regulation of interleukin-17 production (GO:0032660) | 2.73081368 |
| 165 | response to peptidoglycan (GO:0032494) | 2.71599578 |
| 166 | T cell apoptotic process (GO:0070231) | 2.71205995 |
| 167 | regulation of T cell chemotaxis (GO:0010819) | 2.71128243 |
| 168 | positive regulation of T cell chemotaxis (GO:0010820) | 2.71128243 |
| 169 | positive regulation of defense response to virus by host (GO:0002230) | 2.68312440 |
| 170 | positive regulation of protein homooligomerization (GO:0032464) | 2.67961440 |
| 171 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.67542102 |
| 172 | cellular response to interferon-gamma (GO:0071346) | 2.65015453 |
| 173 | T cell costimulation (GO:0031295) | 2.63318456 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.50181363 |
| 2 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.90082627 |
| 3 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.58625214 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.14984420 |
| 5 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.05924239 |
| 6 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.71410324 |
| 7 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.68154489 |
| 8 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.35980889 |
| 9 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.93662505 |
| 10 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.90884609 |
| 11 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.85435673 |
| 12 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.83240095 |
| 13 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.68798605 |
| 14 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.63670898 |
| 15 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.54637365 |
| 16 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.47677426 |
| 17 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.40462975 |
| 18 | * MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.34365684 |
| 19 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.20350722 |
| 20 | MYB_26560356_Chip-Seq_TH2_Human | 2.18207547 |
| 21 | MAF_26560356_Chip-Seq_TH1_Human | 2.17205919 |
| 22 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.12866705 |
| 23 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.06596116 |
| 24 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.06393036 |
| 25 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.02008873 |
| 26 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.94253963 |
| 27 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.93313729 |
| 28 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.88347896 |
| 29 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.85562824 |
| 30 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.83541330 |
| 31 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.82147396 |
| 32 | * MYB_26560356_Chip-Seq_TH1_Human | 1.77645340 |
| 33 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.74613630 |
| 34 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.67433060 |
| 35 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66003737 |
| 36 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63123118 |
| 37 | MYC_22102868_ChIP-Seq_BL_Human | 1.55664518 |
| 38 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.54585554 |
| 39 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.53040477 |
| 40 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.52522826 |
| 41 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.51391529 |
| 42 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.50673894 |
| 43 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.49452790 |
| 44 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.45943437 |
| 45 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.45470323 |
| 46 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.44296230 |
| 47 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.42144173 |
| 48 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.41174494 |
| 49 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.40982386 |
| 50 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.40771892 |
| 51 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.40316312 |
| 52 | * GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.35796625 |
| 53 | * GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.35762407 |
| 54 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.35011852 |
| 55 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.34201228 |
| 56 | MAF_26560356_Chip-Seq_TH2_Human | 1.33188852 |
| 57 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.33138286 |
| 58 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32990132 |
| 59 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.31755801 |
| 60 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.28373811 |
| 61 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.27923812 |
| 62 | * RUNX_20019798_ChIP-Seq_JUKART_Human | 1.27849932 |
| 63 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.27267415 |
| 64 | * TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.25041045 |
| 65 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.24880405 |
| 66 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.24302702 |
| 67 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.22920117 |
| 68 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.21894976 |
| 69 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20156535 |
| 70 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.19795830 |
| 71 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.17685356 |
| 72 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.12653483 |
| 73 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.12537391 |
| 74 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.12411014 |
| 75 | GATA1_19941826_ChIP-Seq_K562_Human | 1.11558242 |
| 76 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.11357984 |
| 77 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.10784144 |
| 78 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.10666794 |
| 79 | * GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.10447626 |
| 80 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.10226026 |
| 81 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.07627737 |
| 82 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.07483617 |
| 83 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.06642994 |
| 84 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.06642994 |
| 85 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.04888852 |
| 86 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.04809293 |
| 87 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.04587077 |
| 88 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04233826 |
| 89 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.03681292 |
| 90 | SPI1_23127762_ChIP-Seq_K562_Human | 1.01765385 |
| 91 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.01697290 |
| 92 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.00739008 |
| 93 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.00638183 |
| 94 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.00430247 |
| 95 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.00143995 |
| 96 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99801475 |
| 97 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.98893010 |
| 98 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.98506243 |
| 99 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.98265774 |
| 100 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.98099070 |
| 101 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.98089665 |
| 102 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97791102 |
| 103 | GATA1_22025678_ChIP-Seq_K562_Human | 0.97723729 |
| 104 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.97531353 |
| 105 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.97340849 |
| 106 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.97112016 |
| 107 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.96606032 |
| 108 | * BCL6_27268052_Chip-Seq_Bcells_Human | 0.96047354 |
| 109 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.94753697 |
| 110 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.94696685 |
| 111 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.94528456 |
| 112 | * GATA3_26560356_Chip-Seq_TH2_Human | 0.93979799 |
| 113 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.93512719 |
| 114 | * CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.92704194 |
| 115 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.91515772 |
| 116 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.91195775 |
| 117 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.90852480 |
| 118 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.89362790 |
| 119 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.87905457 |
| 120 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.86222157 |
| 121 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.85431223 |
| 122 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.85326324 |
| 123 | GATA2_19941826_ChIP-Seq_K562_Human | 0.84958021 |
| 124 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.84612255 |
| 125 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.84236955 |
| 126 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.83239606 |
| 127 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.82709339 |
| 128 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.82336703 |
| 129 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.81910411 |
| 130 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.80977758 |
| 131 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.80074026 |
| 132 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.79889671 |
| 133 | * SPI1_20517297_ChIP-Seq_HL60_Human | 0.78512684 |
| 134 | * RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.73543571 |
| 135 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.72730544 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.43630606 |
| 2 | MP0000685_abnormal_immune_system | 4.09339288 |
| 3 | MP0001348_abnormal_lacrimal_gland | 3.90415422 |
| 4 | MP0009785_altered_susceptibility_to | 3.30917646 |
| 5 | MP0002163_abnormal_gland_morphology | 3.14529620 |
| 6 | MP0002148_abnormal_hypersensitivity_rea | 3.09383005 |
| 7 | MP0005671_abnormal_response_to | 3.02615442 |
| 8 | MP0003436_decreased_susceptibility_to | 2.81556448 |
| 9 | MP0001790_abnormal_immune_system | 2.81409225 |
| 10 | MP0005387_immune_system_phenotype | 2.81409225 |
| 11 | MP0003191_abnormal_cellular_cholesterol | 2.66246789 |
| 12 | MP0005000_abnormal_immune_tolerance | 2.51463965 |
| 13 | MP0008438_abnormal_cutaneous_collagen | 2.51316009 |
| 14 | MP0001346_abnormal_lacrimal_gland | 2.36798105 |
| 15 | MP0002166_altered_tumor_susceptibility | 2.35035224 |
| 16 | MP0005025_abnormal_response_to | 2.27252936 |
| 17 | MP0004510_myositis | 2.23721973 |
| 18 | MP0001800_abnormal_humoral_immune | 2.22113586 |
| 19 | MP0002452_abnormal_antigen_presenting | 2.20508032 |
| 20 | MP0002138_abnormal_hepatobiliary_system | 2.17871921 |
| 21 | MP0002723_abnormal_immune_serum | 2.12823694 |
| 22 | MP0002006_tumorigenesis | 2.11914434 |
| 23 | MP0001819_abnormal_immune_cell | 2.08362334 |
| 24 | MP0002420_abnormal_adaptive_immunity | 2.04396835 |
| 25 | MP0003828_pulmonary_edema | 1.95917165 |
| 26 | MP0002419_abnormal_innate_immunity | 1.94361399 |
| 27 | MP0005058_abnormal_lysosome_morphology | 1.90563320 |
| 28 | MP0008260_abnormal_autophagy | 1.90258986 |
| 29 | MP0003172_abnormal_lysosome_physiology | 1.88930686 |
| 30 | MP0002398_abnormal_bone_marrow | 1.84818525 |
| 31 | MP0003763_abnormal_thymus_physiology | 1.81247382 |
| 32 | MP0001853_heart_inflammation | 1.80544220 |
| 33 | MP0002405_respiratory_system_inflammati | 1.79602255 |
| 34 | MP0000858_altered_metastatic_potential | 1.75142894 |
| 35 | MP0005623_abnormal_meninges_morphology | 1.74863043 |
| 36 | MP0000716_abnormal_immune_system | 1.70932661 |
| 37 | MP0003566_abnormal_cell_adhesion | 1.67353127 |
| 38 | MP0003075_altered_response_to | 1.66422137 |
| 39 | MP0002132_abnormal_respiratory_system | 1.64318722 |
| 40 | MP0009333_abnormal_splenocyte_physiolog | 1.63521367 |
| 41 | MP0010352_gastrointestinal_tract_polyps | 1.57489763 |
| 42 | MP0006082_CNS_inflammation | 1.53994268 |
| 43 | MP0005310_abnormal_salivary_gland | 1.52508790 |
| 44 | MP0004883_abnormal_blood_vessel | 1.51906030 |
| 45 | MP0000465_gastrointestinal_hemorrhage | 1.50495880 |
| 46 | MP0003091_abnormal_cell_migration | 1.48876683 |
| 47 | MP0003448_altered_tumor_morphology | 1.48870334 |
| 48 | MP0004808_abnormal_hematopoietic_stem | 1.46682518 |
| 49 | MP0003279_aneurysm | 1.44620339 |
| 50 | MP0008004_abnormal_stomach_pH | 1.43955499 |
| 51 | MP0010155_abnormal_intestine_physiology | 1.42756493 |
| 52 | MP0002429_abnormal_blood_cell | 1.42578387 |
| 53 | MP0002722_abnormal_immune_system | 1.41436552 |
| 54 | MP0002396_abnormal_hematopoietic_system | 1.40356290 |
| 55 | MP0005076_abnormal_cell_differentiation | 1.38898013 |
| 56 | MP0001533_abnormal_skeleton_physiology | 1.37202100 |
| 57 | MP0003705_abnormal_hypodermis_morpholog | 1.35670502 |
| 58 | MP0003724_increased_susceptibility_to | 1.35058152 |
| 59 | MP0001545_abnormal_hematopoietic_system | 1.32977408 |
| 60 | MP0005397_hematopoietic_system_phenotyp | 1.32977408 |
| 61 | MP0005451_abnormal_body_composition | 1.32433306 |
| 62 | MP0001845_abnormal_inflammatory_respons | 1.30873333 |
| 63 | MP0001851_eye_inflammation | 1.30108563 |
| 64 | MP0003866_abnormal_defecation | 1.30045595 |
| 65 | MP0004947_skin_inflammation | 1.29986744 |
| 66 | MP0000689_abnormal_spleen_morphology | 1.29415643 |
| 67 | MP0005164_abnormal_response_to | 1.27460861 |
| 68 | MP0008057_abnormal_DNA_replication | 1.25813745 |
| 69 | MP0002877_abnormal_melanocyte_morpholog | 1.25174359 |
| 70 | MP0003806_abnormal_nucleotide_metabolis | 1.22432641 |
| 71 | MP0003690_abnormal_glial_cell | 1.22290447 |
| 72 | MP0005166_decreased_susceptibility_to | 1.21965956 |
| 73 | MP0005023_abnormal_wound_healing | 1.20659103 |
| 74 | MP0000604_amyloidosis | 1.19172130 |
| 75 | MP0010307_abnormal_tumor_latency | 1.18118564 |
| 76 | MP0005275_abnormal_skin_tensile | 1.17618413 |
| 77 | MP0005379_endocrine/exocrine_gland_phen | 1.16851458 |
| 78 | MP0002933_joint_inflammation | 1.15893783 |
| 79 | MP0000703_abnormal_thymus_morphology | 1.15194813 |
| 80 | MP0005503_abnormal_tendon_morphology | 1.13146233 |
| 81 | MP0008007_abnormal_cellular_replicative | 1.10041090 |
| 82 | MP0005464_abnormal_platelet_physiology | 1.06707628 |
| 83 | MP0000490_abnormal_crypts_of | 1.06533392 |
| 84 | MP0003303_peritoneal_inflammation | 1.06531686 |
| 85 | MP0003183_abnormal_peptide_metabolism | 1.00325931 |
| 86 | MP0009840_abnormal_foam_cell | 0.99862719 |
| 87 | MP0001873_stomach_inflammation | 0.99242812 |
| 88 | MP0008469_abnormal_protein_level | 0.96569648 |
| 89 | MP0009764_decreased_sensitivity_to | 0.95843344 |
| 90 | MP0002009_preneoplasia | 0.94517996 |
| 91 | MP0003077_abnormal_cell_cycle | 0.94387961 |
| 92 | MP0002277_abnormal_respiratory_mucosa | 0.93682762 |
| 93 | MP0001958_emphysema | 0.90519197 |
| 94 | MP0005390_skeleton_phenotype | 0.89657932 |
| 95 | MP0000767_abnormal_smooth_muscle | 0.88801124 |
| 96 | MP0001542_abnormal_bone_strength | 0.88590532 |
| 97 | MP0002254_reproductive_system_inflammat | 0.87896963 |
| 98 | MP0002019_abnormal_tumor_incidence | 0.86643633 |
| 99 | MP0006054_spinal_hemorrhage | 0.85346650 |
| 100 | MP0009278_abnormal_bone_marrow | 0.84720890 |
| 101 | MP0001915_intracranial_hemorrhage | 0.84323401 |
| 102 | MP0000343_altered_response_to | 0.82910047 |
| 103 | MP0003795_abnormal_bone_structure | 0.82250719 |
| 104 | MP0001663_abnormal_digestive_system | 0.81325596 |
| 105 | MP0001243_abnormal_dermal_layer | 0.80107662 |
| 106 | MP0003693_abnormal_embryo_hatching | 0.75545782 |
| 107 | MP0004381_abnormal_hair_follicle | 0.73281716 |
| 108 | MP0002133_abnormal_respiratory_system | 0.70803058 |
| 109 | MP0005388_respiratory_system_phenotype | 0.70803058 |
| 110 | MP0000733_abnormal_muscle_development | 0.70580217 |
| 111 | MP0009765_abnormal_xenobiotic_induced | 0.69849471 |
| 112 | MP0000350_abnormal_cell_proliferation | 0.69226626 |
| 113 | MP0004957_abnormal_blastocyst_morpholog | 0.69181442 |
| 114 | MP0002998_abnormal_bone_remodeling | 0.68970238 |
| 115 | MP0003656_abnormal_erythrocyte_physiolo | 0.66698886 |
| 116 | MP0000627_abnormal_mammary_gland | 0.65714580 |
| 117 | MP0005084_abnormal_gallbladder_morpholo | 0.65501918 |
| 118 | MP0001879_abnormal_lymphatic_vessel | 0.65430115 |
| 119 | MP0003186_abnormal_redox_activity | 0.64741984 |
| 120 | MP0003453_abnormal_keratinocyte_physiol | 0.64598624 |
| 121 | MP0003941_abnormal_skin_development | 0.63584932 |
| 122 | MP0000920_abnormal_myelination | 0.59974377 |
| 123 | MP0000249_abnormal_blood_vessel | 0.59947408 |
| 124 | MP0005319_abnormal_enzyme/_coenzyme | 0.59923233 |
| 125 | MP0009763_increased_sensitivity_to | 0.59831553 |
| 126 | MP0001881_abnormal_mammary_gland | 0.59178613 |
| 127 | MP0003300_gastrointestinal_ulcer | 0.58644411 |
| 128 | MP0001986_abnormal_taste_sensitivity | 0.58548889 |
| 129 | MP0005621_abnormal_cell_physiology | 0.57030564 |
| 130 | MP0000569_abnormal_digit_pigmentation | 0.56700073 |
| 131 | MP0002332_abnormal_exercise_endurance | 0.56054749 |
| 132 | MP0000313_abnormal_cell_death | 0.54969691 |
| 133 | MP0005167_abnormal_blood-brain_barrier | 0.53470794 |
| 134 | MP0003045_fibrosis | 0.53121969 |
| 135 | MP0008874_decreased_physiological_sensi | 0.52185905 |
| 136 | MP0005381_digestive/alimentary_phenotyp | 0.49731991 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myositis (HP:0100614) | 5.17569124 |
| 2 | Increased IgM level (HP:0003496) | 5.15591021 |
| 3 | Optic neuritis (HP:0100653) | 5.10469893 |
| 4 | Retrobulbar optic neuritis (HP:0100654) | 5.10469893 |
| 5 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.01676117 |
| 6 | Orchitis (HP:0100796) | 5.01526636 |
| 7 | Stomatitis (HP:0010280) | 4.87820413 |
| 8 | Eczematoid dermatitis (HP:0000976) | 4.42752290 |
| 9 | Autoimmune thrombocytopenia (HP:0001973) | 4.37069283 |
| 10 | Recurrent abscess formation (HP:0002722) | 4.12367452 |
| 11 | Gastrointestinal infarctions (HP:0005244) | 3.85568486 |
| 12 | Peritonitis (HP:0002586) | 3.82139292 |
| 13 | Recurrent bacterial skin infections (HP:0005406) | 3.75027958 |
| 14 | Chronic otitis media (HP:0000389) | 3.73727215 |
| 15 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.53752611 |
| 16 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.53752611 |
| 17 | Abnormality of glycolipid metabolism (HP:0010969) | 3.53752611 |
| 18 | Recurrent fungal infections (HP:0002841) | 3.43518660 |
| 19 | Vertebral compression fractures (HP:0002953) | 3.41825139 |
| 20 | Thrombocytosis (HP:0001894) | 3.40058676 |
| 21 | Vasculitis (HP:0002633) | 3.36297180 |
| 22 | Arterial thrombosis (HP:0004420) | 3.27769166 |
| 23 | Abnormality of T cell number (HP:0011839) | 3.23797541 |
| 24 | Protrusio acetabuli (HP:0003179) | 3.22205597 |
| 25 | Hypergammaglobulinemia (HP:0010702) | 3.20905009 |
| 26 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.19426682 |
| 27 | Keratoconjunctivitis sicca (HP:0001097) | 3.14264575 |
| 28 | Amyloidosis (HP:0011034) | 3.12792620 |
| 29 | Abnormality of macrophages (HP:0004311) | 2.96986674 |
| 30 | Recurrent viral infections (HP:0004429) | 2.95015526 |
| 31 | Mediastinal lymphadenopathy (HP:0100721) | 2.94522180 |
| 32 | Nasal polyposis (HP:0100582) | 2.92844772 |
| 33 | Keratoconjunctivitis (HP:0001096) | 2.91087208 |
| 34 | Pulmonary infiltrates (HP:0002113) | 2.89234197 |
| 35 | Premature rupture of membranes (HP:0001788) | 2.88781486 |
| 36 | Increased cerebral lipofuscin (HP:0011813) | 2.84921412 |
| 37 | Episodic fever (HP:0001954) | 2.83939712 |
| 38 | Prolonged bleeding time (HP:0003010) | 2.82644873 |
| 39 | Hypochromic microcytic anemia (HP:0004840) | 2.78908838 |
| 40 | Basal ganglia calcification (HP:0002135) | 2.70193131 |
| 41 | Hemoptysis (HP:0002105) | 2.69574749 |
| 42 | Leukocytosis (HP:0001974) | 2.68965586 |
| 43 | Eosinophilia (HP:0001880) | 2.68918052 |
| 44 | Loss of speech (HP:0002371) | 2.68036266 |
| 45 | Systemic lupus erythematosus (HP:0002725) | 2.66019182 |
| 46 | Recurrent bronchitis (HP:0002837) | 2.61257378 |
| 47 | Gingival bleeding (HP:0000225) | 2.59650826 |
| 48 | Abnormality of T cells (HP:0002843) | 2.59481508 |
| 49 | Abnormality of the nasal mucosa (HP:0000433) | 2.59341705 |
| 50 | Pulmonary embolism (HP:0002204) | 2.57986871 |
| 51 | Recurrent skin infections (HP:0001581) | 2.56993490 |
| 52 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.55985508 |
| 53 | Epistaxis (HP:0000421) | 2.55655615 |
| 54 | Abnormality of T cell physiology (HP:0011840) | 2.55184195 |
| 55 | Amaurosis fugax (HP:0100576) | 2.52162611 |
| 56 | Purpura (HP:0000979) | 2.51656304 |
| 57 | Hepatosplenomegaly (HP:0001433) | 2.51185252 |
| 58 | Granulocytopenia (HP:0001913) | 2.49158671 |
| 59 | Syringomyelia (HP:0003396) | 2.48798740 |
| 60 | Spinal cord lesions (HP:0100561) | 2.48798740 |
| 61 | Autoimmune hemolytic anemia (HP:0001890) | 2.45321590 |
| 62 | Vacuolated lymphocytes (HP:0001922) | 2.43244566 |
| 63 | Encephalitis (HP:0002383) | 2.41679099 |
| 64 | Osteolytic defects of the hand bones (HP:0009699) | 2.41567011 |
| 65 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.41567011 |
| 66 | Meningitis (HP:0001287) | 2.40395352 |
| 67 | T lymphocytopenia (HP:0005403) | 2.39415158 |
| 68 | Porencephaly (HP:0002132) | 2.38906240 |
| 69 | Dysostosis multiplex (HP:0000943) | 2.38592733 |
| 70 | Cellulitis (HP:0100658) | 2.37642996 |
| 71 | Joint swelling (HP:0001386) | 2.36430370 |
| 72 | Aortic dissection (HP:0002647) | 2.33711322 |
| 73 | Dilatation of the ascending aorta (HP:0005111) | 2.33614969 |
| 74 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.33476452 |
| 75 | Recurrent cutaneous fungal infections (HP:0011370) | 2.33476452 |
| 76 | Osteomyelitis (HP:0002754) | 2.33403928 |
| 77 | Chronic obstructive pulmonary disease (HP:0006510) | 2.32037637 |
| 78 | Obstructive lung disease (HP:0006536) | 2.32037637 |
| 79 | Inflammation of the large intestine (HP:0002037) | 2.30996365 |
| 80 | Abnormality of the pericardium (HP:0001697) | 2.28779262 |
| 81 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.27540671 |
| 82 | Increased serum ferritin (HP:0003281) | 2.25135197 |
| 83 | Disinhibition (HP:0000734) | 2.23035793 |
| 84 | Biconcave vertebral bodies (HP:0004586) | 2.22842957 |
| 85 | Hypochromic anemia (HP:0001931) | 2.21258539 |
| 86 | Abnormality of eosinophils (HP:0001879) | 2.20817180 |
| 87 | Anorexia (HP:0002039) | 2.18812726 |
| 88 | Chest pain (HP:0100749) | 2.18507733 |
| 89 | Glomerulopathy (HP:0100820) | 2.18414747 |
| 90 | Gastrointestinal inflammation (HP:0004386) | 2.17996313 |
| 91 | IgG deficiency (HP:0004315) | 2.16994301 |
| 92 | Long palpebral fissure (HP:0000637) | 2.16002407 |
| 93 | Gangrene (HP:0100758) | 2.14367135 |
| 94 | Cervical subluxation (HP:0003308) | 2.14184058 |
| 95 | Urticaria (HP:0001025) | 2.12831559 |
| 96 | Petechiae (HP:0000967) | 2.12768682 |
| 97 | IgA deficiency (HP:0002720) | 2.09179387 |
| 98 | Tetraparesis (HP:0002273) | 2.08903268 |
| 99 | Abnormality of iron homeostasis (HP:0011031) | 2.07863986 |
| 100 | Periodontitis (HP:0000704) | 2.07572602 |
| 101 | Microcytic anemia (HP:0001935) | 2.07565970 |
| 102 | Vertigo (HP:0002321) | 2.07355318 |
| 103 | Panhypogammaglobulinemia (HP:0003139) | 2.04426994 |
| 104 | Cerebral ischemia (HP:0002637) | 2.04186261 |
| 105 | Bilateral sensorineural hearing impairment (HP:0008619) | 2.02784377 |
| 106 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.02229803 |
| 107 | Polyneuropathy (HP:0001271) | 2.01918429 |
| 108 | Fatigue (HP:0012378) | 2.01067905 |
| 109 | Lymphopenia (HP:0001888) | 1.98361981 |
| 110 | Abnormality of the pleura (HP:0002103) | 1.97494773 |
| 111 | Cerebral aneurysm (HP:0004944) | 1.96854495 |
| 112 | Increased IgE level (HP:0003212) | 1.96064467 |
| 113 | Sepsis (HP:0100806) | 1.94315517 |
| 114 | Premature loss of primary teeth (HP:0006323) | 1.94289356 |
| 115 | Acne (HP:0001061) | 1.93388491 |
| 116 | Chronic sinusitis (HP:0011109) | 1.92139727 |
| 117 | Gingivitis (HP:0000230) | 1.91436050 |
| 118 | Abnormality of the peritoneum (HP:0002585) | 1.91234514 |
| 119 | Aortic aneurysm (HP:0004942) | 1.90665098 |
| 120 | Interstitial pulmonary disease (HP:0006530) | 1.89265476 |
| 121 | Recurrent lower respiratory tract infections (HP:0002783) | 1.88725714 |
| 122 | Increased density of long bones (HP:0006392) | 1.87796358 |
| 123 | Restrictive lung disease (HP:0002091) | 1.86069106 |
| 124 | Keratitis (HP:0000491) | 1.84938116 |
| 125 | Recurrent pneumonia (HP:0006532) | 1.84762350 |
| 126 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.84584888 |
| 127 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.84584888 |
| 128 | Abnormal platelet volume (HP:0011876) | 1.83621023 |
| 129 | Skin ulcer (HP:0200042) | 1.83157441 |
| 130 | Pustule (HP:0200039) | 1.82777952 |
| 131 | Spontaneous hematomas (HP:0007420) | 1.82644321 |
| 132 | Emphysema (HP:0002097) | 1.77191604 |
| 133 | Abnormality of the endocardium (HP:0004306) | 1.73103293 |
| 134 | Cleft eyelid (HP:0000625) | 1.73089438 |
| 135 | Hematochezia (HP:0002573) | 1.71650006 |
| 136 | Acrocyanosis (HP:0001063) | 1.70506772 |
| 137 | Persistence of primary teeth (HP:0006335) | 1.69507681 |
| 138 | Increased mean platelet volume (HP:0011877) | 1.69071025 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RIPK4 | 4.48019563 |
| 2 | MAP3K14 | 4.11154244 |
| 3 | TYK2 | 3.37196885 |
| 4 | JAK3 | 3.30017762 |
| 5 | PIM2 | 3.10437498 |
| 6 | FES | 2.91045871 |
| 7 | TESK1 | 2.88935084 |
| 8 | IKBKB | 2.81270331 |
| 9 | TBK1 | 2.75097236 |
| 10 | TESK2 | 2.52775798 |
| 11 | MAP4K1 | 2.50596258 |
| 12 | IRAK4 | 2.27425951 |
| 13 | IKBKE | 2.18051949 |
| 14 | JAK1 | 2.04343304 |
| 15 | BLK | 2.02735127 |
| 16 | TNK2 | 1.98638375 |
| 17 | CHUK | 1.92907365 |
| 18 | FGR | 1.89243438 |
| 19 | TXK | 1.83511994 |
| 20 | PRPF4B | 1.77865308 |
| 21 | RPS6KA4 | 1.76098354 |
| 22 | LIMK1 | 1.75932379 |
| 23 | STK10 | 1.70592508 |
| 24 | ZAP70 | 1.64789078 |
| 25 | LRRK2 | 1.64703169 |
| 26 | NME2 | 1.61654647 |
| 27 | PIM1 | 1.58402933 |
| 28 | MAP3K13 | 1.58040339 |
| 29 | TGFBR2 | 1.57451512 |
| 30 | TAOK1 | 1.54815668 |
| 31 | ACVR1B | 1.40991638 |
| 32 | FGFR4 | 1.38947073 |
| 33 | NEK9 | 1.36876392 |
| 34 | EPHB1 | 1.34289501 |
| 35 | MATK | 1.32891515 |
| 36 | TTN | 1.31650798 |
| 37 | BCR | 1.29446487 |
| 38 | GRK7 | 1.28337664 |
| 39 | TAOK3 | 1.27278117 |
| 40 | EIF2AK1 | 1.27250578 |
| 41 | FLT3 | 1.26855304 |
| 42 | ARAF | 1.24116962 |
| 43 | KIT | 1.21738553 |
| 44 | BTK | 1.19911615 |
| 45 | EIF2AK2 | 1.15901973 |
| 46 | TRIB3 | 1.15834094 |
| 47 | TRPM7 | 1.15810509 |
| 48 | MAP3K1 | 1.12754764 |
| 49 | STK24 | 1.12226988 |
| 50 | TGFBR1 | 1.07491480 |
| 51 | YES1 | 1.01594738 |
| 52 | SYK | 1.01397527 |
| 53 | ILK | 1.00154383 |
| 54 | KSR2 | 0.96298826 |
| 55 | CSK | 0.94410665 |
| 56 | CDK19 | 0.93612762 |
| 57 | TEC | 0.92151574 |
| 58 | HCK | 0.91527703 |
| 59 | BMPR2 | 0.91380240 |
| 60 | KDR | 0.90990457 |
| 61 | EPHA3 | 0.90828031 |
| 62 | PIK3CG | 0.90420289 |
| 63 | LCK | 0.90087022 |
| 64 | STK4 | 0.89841357 |
| 65 | TAOK2 | 0.89194604 |
| 66 | MST4 | 0.88527854 |
| 67 | MAP3K8 | 0.86734615 |
| 68 | MOS | 0.85236130 |
| 69 | PAK4 | 0.84687863 |
| 70 | ERBB3 | 0.84010590 |
| 71 | PRKD2 | 0.83628116 |
| 72 | MAPKAPK2 | 0.81375163 |
| 73 | CSF1R | 0.80293372 |
| 74 | PTK6 | 0.80292083 |
| 75 | IRAK1 | 0.79955756 |
| 76 | MAP2K3 | 0.79904443 |
| 77 | MAP3K6 | 0.79816063 |
| 78 | PDK1 | 0.76987398 |
| 79 | SCYL2 | 0.76331505 |
| 80 | MARK2 | 0.76021702 |
| 81 | FGFR3 | 0.74128240 |
| 82 | CDC42BPA | 0.73997046 |
| 83 | ITK | 0.72928376 |
| 84 | MAP3K5 | 0.71173688 |
| 85 | MAP2K6 | 0.69600497 |
| 86 | PKN2 | 0.68926464 |
| 87 | FYN | 0.68496050 |
| 88 | PDPK1 | 0.68245858 |
| 89 | STK3 | 0.67820065 |
| 90 | SIK3 | 0.65784976 |
| 91 | MAPK7 | 0.64325142 |
| 92 | MYLK | 0.63927054 |
| 93 | MAP3K11 | 0.62957560 |
| 94 | BMX | 0.62155561 |
| 95 | ZAK | 0.61546191 |
| 96 | IRAK2 | 0.60890341 |
| 97 | PAK1 | 0.60509734 |
| 98 | CDK6 | 0.55988822 |
| 99 | NLK | 0.55786952 |
| 100 | BUB1 | 0.55140122 |
| 101 | MAPK12 | 0.54570111 |
| 102 | DAPK3 | 0.54242472 |
| 103 | IRAK3 | 0.52607946 |
| 104 | MARK3 | 0.52601938 |
| 105 | LYN | 0.52158239 |
| 106 | SRPK1 | 0.51878130 |
| 107 | MAP3K2 | 0.51551683 |
| 108 | ABL2 | 0.51503391 |
| 109 | GRK6 | 0.50660473 |
| 110 | EIF2AK3 | 0.50282118 |
| 111 | RPS6KC1 | 0.50058014 |
| 112 | RPS6KL1 | 0.50058014 |
| 113 | RAF1 | 0.49452131 |
| 114 | NEK2 | 0.49257956 |
| 115 | MAP3K3 | 0.48553113 |
| 116 | PRKCQ | 0.48481058 |
| 117 | JAK2 | 0.48099622 |
| 118 | PTK2B | 0.47806313 |
| 119 | CDK4 | 0.47708060 |
| 120 | PTK2 | 0.47043364 |
| 121 | PRKCD | 0.45620550 |
| 122 | PLK4 | 0.45160115 |
| 123 | DMPK | 0.45088215 |
| 124 | RPS6KA5 | 0.44893136 |
| 125 | DYRK1B | 0.44732038 |
| 126 | RPS6KB2 | 0.41964896 |
| 127 | BRSK2 | 0.41763246 |
| 128 | CDC7 | 0.38925148 |
| 129 | EEF2K | 0.37308903 |
| 130 | ERN1 | 0.37270651 |
| 131 | RPS6KA6 | 0.36846450 |
| 132 | HIPK2 | 0.36471494 |
| 133 | ABL1 | 0.34128370 |
| 134 | MAP3K10 | 0.33691428 |
| 135 | MAP3K12 | 0.33597335 |
| 136 | PDGFRB | 0.33533535 |
| 137 | MAP3K7 | 0.31787018 |
| 138 | CAMKK2 | 0.31748144 |
| 139 | RPS6KA2 | 0.30607424 |
| 140 | STK11 | 0.30393412 |
| 141 | PRKD1 | 0.28474209 |
| 142 | KSR1 | 0.27908857 |
| 143 | EGFR | 0.27732706 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Allograft rejection_Homo sapiens_hsa05330 | 4.14331528 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.68305761 |
| 3 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.81832837 |
| 4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.64246189 |
| 5 | Measles_Homo sapiens_hsa05162 | 2.38032280 |
| 6 | Leishmaniasis_Homo sapiens_hsa05140 | 2.33603717 |
| 7 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.33312045 |
| 8 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.21849348 |
| 9 | Viral myocarditis_Homo sapiens_hsa05416 | 2.21417787 |
| 10 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.20432364 |
| 11 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.92311651 |
| 12 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.89989347 |
| 13 | Proteasome_Homo sapiens_hsa03050 | 1.86943150 |
| 14 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.86252564 |
| 15 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.83963263 |
| 16 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.83715521 |
| 17 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.75632162 |
| 18 | Shigellosis_Homo sapiens_hsa05131 | 1.75301522 |
| 19 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.73900259 |
| 20 | Other glycan degradation_Homo sapiens_hsa00511 | 1.72573594 |
| 21 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.67350895 |
| 22 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.63541301 |
| 23 | Influenza A_Homo sapiens_hsa05164 | 1.62444392 |
| 24 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.62327480 |
| 25 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.61722136 |
| 26 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.60492389 |
| 27 | Apoptosis_Homo sapiens_hsa04210 | 1.55646785 |
| 28 | Lysosome_Homo sapiens_hsa04142 | 1.52739920 |
| 29 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.50519987 |
| 30 | Legionellosis_Homo sapiens_hsa05134 | 1.48079715 |
| 31 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.46192206 |
| 32 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.44290641 |
| 33 | Malaria_Homo sapiens_hsa05144 | 1.42966924 |
| 34 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.42235834 |
| 35 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.34090949 |
| 36 | Ribosome_Homo sapiens_hsa03010 | 1.32522522 |
| 37 | Pertussis_Homo sapiens_hsa05133 | 1.31366822 |
| 38 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.28165850 |
| 39 | Hepatitis B_Homo sapiens_hsa05161 | 1.25128253 |
| 40 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.19648948 |
| 41 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.17522850 |
| 42 | Asthma_Homo sapiens_hsa05310 | 1.14151130 |
| 43 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.13058946 |
| 44 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.11750344 |
| 45 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.11426525 |
| 46 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.08793071 |
| 47 | DNA replication_Homo sapiens_hsa03030 | 1.07335719 |
| 48 | Tuberculosis_Homo sapiens_hsa05152 | 1.07302375 |
| 49 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.06260101 |
| 50 | Salmonella infection_Homo sapiens_hsa05132 | 1.05805622 |
| 51 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.04312499 |
| 52 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.03034133 |
| 53 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.03023653 |
| 54 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.98570451 |
| 55 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.97982420 |
| 56 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.96896654 |
| 57 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.94809162 |
| 58 | HTLV-I infection_Homo sapiens_hsa05166 | 0.94191399 |
| 59 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.94139617 |
| 60 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.91680250 |
| 61 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.89008397 |
| 62 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.86932373 |
| 63 | Base excision repair_Homo sapiens_hsa03410 | 0.85238389 |
| 64 | Hepatitis C_Homo sapiens_hsa05160 | 0.78107364 |
| 65 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.77454755 |
| 66 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.73787665 |
| 67 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.72276835 |
| 68 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.71743868 |
| 69 | Adherens junction_Homo sapiens_hsa04520 | 0.71727962 |
| 70 | Cell cycle_Homo sapiens_hsa04110 | 0.71217521 |
| 71 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.70463426 |
| 72 | Amoebiasis_Homo sapiens_hsa05146 | 0.68279250 |
| 73 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.67939587 |
| 74 | Focal adhesion_Homo sapiens_hsa04510 | 0.63846253 |
| 75 | Mismatch repair_Homo sapiens_hsa03430 | 0.63796819 |
| 76 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.63068923 |
| 77 | Platelet activation_Homo sapiens_hsa04611 | 0.62960178 |
| 78 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.62444170 |
| 79 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.61412763 |
| 80 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.59363843 |
| 81 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.56925396 |
| 82 | Spliceosome_Homo sapiens_hsa03040 | 0.54429260 |
| 83 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.53684162 |
| 84 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.52156678 |
| 85 | Phagosome_Homo sapiens_hsa04145 | 0.51882626 |
| 86 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.51657007 |
| 87 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.50645323 |
| 88 | Homologous recombination_Homo sapiens_hsa03440 | 0.50144127 |
| 89 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.50094419 |
| 90 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.48795944 |
| 91 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.47581878 |
| 92 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.46188634 |
| 93 | RNA transport_Homo sapiens_hsa03013 | 0.44765890 |
| 94 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.43975986 |
| 95 | Pathways in cancer_Homo sapiens_hsa05200 | 0.43136240 |
| 96 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.39235507 |
| 97 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.39011086 |
| 98 | Colorectal cancer_Homo sapiens_hsa05210 | 0.37740033 |
| 99 | Bladder cancer_Homo sapiens_hsa05219 | 0.36922527 |
| 100 | RNA polymerase_Homo sapiens_hsa03020 | 0.36107314 |
| 101 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.35593915 |
| 102 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.35500008 |
| 103 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.35239844 |
| 104 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.35222819 |
| 105 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.34752790 |
| 106 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.34388322 |
| 107 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.34134888 |
| 108 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.33859362 |
| 109 | Thyroid cancer_Homo sapiens_hsa05216 | 0.30921979 |
| 110 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.30766692 |
| 111 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.30375073 |
| 112 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.30128439 |
| 113 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.30084793 |
| 114 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.29957513 |
| 115 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.29493167 |
| 116 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.29279012 |
| 117 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.28743023 |
| 118 | Prostate cancer_Homo sapiens_hsa05215 | 0.28716425 |
| 119 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.28583226 |
| 120 | Endocytosis_Homo sapiens_hsa04144 | 0.27358513 |
| 121 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.27066260 |
| 122 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.27039063 |
| 123 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.26543318 |
| 124 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.26154951 |
| 125 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.25866670 |
| 126 | Insulin resistance_Homo sapiens_hsa04931 | 0.23718647 |
| 127 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.22619281 |
| 128 | Endometrial cancer_Homo sapiens_hsa05213 | 0.22122343 |

