GLIS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1notochord development (GO:0030903)6.43200591
2mesenchymal-epithelial cell signaling (GO:0060638)5.92723551
3cell migration involved in heart development (GO:0060973)5.74810958
4glomerular basement membrane development (GO:0032836)5.34335665
5piRNA metabolic process (GO:0034587)5.14992262
6regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.95617505
7cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.90556835
8endodermal cell differentiation (GO:0035987)4.81870881
9negative regulation of smooth muscle cell differentiation (GO:0051151)4.76439957
10kidney mesenchyme development (GO:0072074)4.75613186
11chondrocyte development (GO:0002063)4.49991177
12collagen fibril organization (GO:0030199)4.49122505
13paraxial mesoderm development (GO:0048339)4.48248149
14sequestering of extracellular ligand from receptor (GO:0035581)4.34751936
15metanephric mesenchyme development (GO:0072075)4.30734418
16cell aggregation (GO:0098743)4.30531386
17cartilage condensation (GO:0001502)4.30531386
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.17463548
19extracellular matrix assembly (GO:0085029)4.11055020
20mitotic metaphase plate congression (GO:0007080)3.93312733
21peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.91385969
22regulation of meiosis I (GO:0060631)3.87920646
23regulation of meiosis (GO:0040020)3.85356006
24mitotic nuclear envelope disassembly (GO:0007077)3.85064909
25positive regulation of extracellular matrix organization (GO:1903055)3.84244290
26male meiosis (GO:0007140)3.81909454
27collagen metabolic process (GO:0032963)3.77840407
28planar cell polarity pathway involved in neural tube closure (GO:0090179)3.75555178
29myelination in peripheral nervous system (GO:0022011)3.75053732
30peripheral nervous system axon ensheathment (GO:0032292)3.75053732
31mitotic chromosome condensation (GO:0007076)3.70944050
32membrane disassembly (GO:0030397)3.68230930
33nuclear envelope disassembly (GO:0051081)3.68230930
34collagen catabolic process (GO:0030574)3.64740546
35regulation of transforming growth factor beta2 production (GO:0032909)3.64149797
36peptidyl-proline hydroxylation (GO:0019511)3.61677983
37regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.61337254
38regulation of apoptotic process involved in morphogenesis (GO:1902337)3.58497069
39DNA methylation involved in gamete generation (GO:0043046)3.56320493
40attachment of spindle microtubules to kinetochore (GO:0008608)3.53261860
41multicellular organismal macromolecule metabolic process (GO:0044259)3.51845303
42female gamete generation (GO:0007292)3.51714996
43regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41449704
44positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.40368483
45venous blood vessel morphogenesis (GO:0048845)3.35998335
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35328582
47positive regulation of blood vessel endothelial cell migration (GO:0043536)3.34686907
48cell adhesion mediated by integrin (GO:0033627)3.34363665
49cellular response to vitamin (GO:0071295)3.34201634
50metaphase plate congression (GO:0051310)3.33363008
51multicellular organismal metabolic process (GO:0044236)3.32141957
52multicellular organismal catabolic process (GO:0044243)3.31688665
53heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.31328686
54dermatan sulfate biosynthetic process (GO:0030208)3.30597539
55protein localization to cell surface (GO:0034394)3.29857677
56substrate-dependent cell migration (GO:0006929)3.29120419
57regulation of integrin-mediated signaling pathway (GO:2001044)3.28865667
58mitotic sister chromatid segregation (GO:0000070)3.25282523
59histone H2A monoubiquitination (GO:0035518)3.24430178
60type B pancreatic cell proliferation (GO:0044342)3.24175087
61keratan sulfate catabolic process (GO:0042340)3.24011150
62meiotic cell cycle (GO:0051321)3.23704270
63negative regulation of chondrocyte differentiation (GO:0032331)3.22533892
64protein hydroxylation (GO:0018126)3.22524143
65vascular endothelial growth factor signaling pathway (GO:0038084)3.21554869
66regulation of spindle organization (GO:0090224)3.20470395
67regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.18058411
68camera-type eye morphogenesis (GO:0048593)3.16895544
69extracellular fibril organization (GO:0043206)3.16495452
70dermatan sulfate metabolic process (GO:0030205)3.16420243
71actin filament depolymerization (GO:0030042)3.14991486
72negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.14141804
73regulation of mitotic spindle organization (GO:0060236)3.13852752
74negative regulation of meiosis (GO:0045835)3.13252595
75pericardium development (GO:0060039)3.12178131
76extracellular matrix disassembly (GO:0022617)3.12039921
77positive regulation of epithelial to mesenchymal transition (GO:0010718)3.11405038
78type B pancreatic cell development (GO:0003323)3.10915763
79skin morphogenesis (GO:0043589)3.10153007
80meiotic chromosome segregation (GO:0045132)3.09236083
81gene silencing by RNA (GO:0031047)3.08338002
82basement membrane organization (GO:0071711)3.07957847
83cell migration involved in sprouting angiogenesis (GO:0002042)3.07668485
84protein retention in ER lumen (GO:0006621)3.04638610
85negative regulation of fatty acid transport (GO:2000192)3.04018282
86negative regulation of smooth muscle cell migration (GO:0014912)3.03551288
87positive regulation of fibroblast migration (GO:0010763)3.01845341
88endocardial cushion development (GO:0003197)3.01055799
89cartilage morphogenesis (GO:0060536)3.00983765
90embryonic skeletal joint morphogenesis (GO:0060272)3.00437395
91positive regulation of axon extension (GO:0045773)2.99064559
92chondrocyte proliferation (GO:0035988)2.98575937
93vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.96918235
94cellular response to vitamin D (GO:0071305)2.95286089
95virion attachment to host cell (GO:0019062)2.93363148
96adhesion of symbiont to host cell (GO:0044650)2.93363148
97regulation of meiotic cell cycle (GO:0051445)2.92299792
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.92211679
99nuclear pore complex assembly (GO:0051292)2.91564070
100synaptonemal complex assembly (GO:0007130)2.90560948
101oocyte maturation (GO:0001556)2.88854769
102kinetochore assembly (GO:0051382)2.88805444
103endothelial cell chemotaxis (GO:0035767)2.88701844
104regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.88126467
105extracellular matrix organization (GO:0030198)2.87752488
106maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87469485
107cell-substrate junction assembly (GO:0007044)2.87456005
108extracellular structure organization (GO:0043062)2.86803432
109embryonic viscerocranium morphogenesis (GO:0048703)2.85949226
110cochlea morphogenesis (GO:0090103)2.85025815
111embryonic camera-type eye development (GO:0031076)2.84695899
112embryonic cranial skeleton morphogenesis (GO:0048701)2.84314191
113nuclear envelope organization (GO:0006998)2.84187814
114craniofacial suture morphogenesis (GO:0097094)2.83967266
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83775568
116axon extension involved in axon guidance (GO:0048846)2.83490583
117neuron projection extension involved in neuron projection guidance (GO:1902284)2.83490583
118establishment of chromosome localization (GO:0051303)2.82436933
119negative regulation of BMP signaling pathway (GO:0030514)2.81452019
120Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.81322129
121regulation of female gonad development (GO:2000194)2.81028047
122outer ear morphogenesis (GO:0042473)2.81001150
123spindle checkpoint (GO:0031577)2.80452111
124smooth muscle tissue development (GO:0048745)2.79064624
125sister chromatid segregation (GO:0000819)2.78662854
126wound healing, spreading of cells (GO:0044319)2.77899962
127maturation of 5.8S rRNA (GO:0000460)2.77893291
128regulation of axon extension involved in axon guidance (GO:0048841)2.76939625
129chromosome segregation (GO:0007059)2.76477114
130fibroblast migration (GO:0010761)2.76366515
131muscle cell fate commitment (GO:0042693)2.75851092
132bone trabecula formation (GO:0060346)2.75631347
133positive regulation of mitotic sister chromatid separation (GO:1901970)2.75595361
134positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75595361
135positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75595361
136tooth mineralization (GO:0034505)2.74012258
137non-canonical Wnt signaling pathway (GO:0035567)2.72736595
138protein localization to kinetochore (GO:0034501)2.72241362
139DNA damage induced protein phosphorylation (GO:0006975)2.71932295
140adherens junction assembly (GO:0034333)2.71743421
141ventricular cardiac muscle cell development (GO:0055015)2.71066600
142regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.70592788
143mitotic spindle assembly checkpoint (GO:0007094)2.69499978
144mitotic spindle checkpoint (GO:0071174)2.68967430
145histone H2A ubiquitination (GO:0033522)2.68354043
146lymphangiogenesis (GO:0001946)2.67040852
147regulation of hippo signaling (GO:0035330)2.66559627
148regulation of extracellular matrix disassembly (GO:0010715)2.65999120
149protein K6-linked ubiquitination (GO:0085020)2.65978625
150adhesion of symbiont to host (GO:0044406)2.65943031
151DNA alkylation (GO:0006305)2.65540453
152DNA methylation (GO:0006306)2.65540453
153regulation of establishment of planar polarity (GO:0090175)2.64659365
154regulation of chromosome segregation (GO:0051983)2.63787107
155endothelial cell morphogenesis (GO:0001886)2.63709509
156heparan sulfate proteoglycan metabolic process (GO:0030201)2.63525112
157glandular epithelial cell development (GO:0002068)2.63460859
158cartilage development (GO:0051216)2.63242648
159negative regulation of chromosome segregation (GO:0051985)2.62429103
160synaptonemal complex organization (GO:0070193)2.62112265
161regulation of cell aging (GO:0090342)2.61955798
162spindle assembly checkpoint (GO:0071173)2.61853811
163wound healing, spreading of epidermal cells (GO:0035313)2.61811909
164induction of positive chemotaxis (GO:0050930)2.61411782
165negative regulation of axon guidance (GO:1902668)2.61396842
166middle ear morphogenesis (GO:0042474)2.61395688
167focal adhesion assembly (GO:0048041)2.61185985
168cell-substrate adherens junction assembly (GO:0007045)2.61185985
169protein localization to chromosome (GO:0034502)2.60978986
170nuclear pore organization (GO:0006999)2.60643324
171negative regulation of osteoblast proliferation (GO:0033689)2.60116552
172regulation of sister chromatid cohesion (GO:0007063)2.59688147
173fibril organization (GO:0097435)2.59651056
174kinetochore organization (GO:0051383)2.59614876
175monoubiquitinated protein deubiquitination (GO:0035520)2.59161076
176mitotic sister chromatid cohesion (GO:0007064)2.58437969
177negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57809888
178negative regulation of sister chromatid segregation (GO:0033046)2.57809888
179negative regulation of mitotic sister chromatid separation (GO:2000816)2.57809888
180negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57809888
181negative regulation of reproductive process (GO:2000242)2.56741047
182protein heterotrimerization (GO:0070208)2.53534557
183regulation of retinoic acid receptor signaling pathway (GO:0048385)2.53150127
184positive regulation of chondrocyte differentiation (GO:0032332)2.52832479
185positive regulation of chromosome segregation (GO:0051984)2.52777576
186regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.52770831
187negative regulation of hormone biosynthetic process (GO:0032353)2.52129216
188negative regulation of hormone metabolic process (GO:0032351)2.52129216
189regulation of keratinocyte proliferation (GO:0010837)2.51990291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.60650473
2E2F7_22180533_ChIP-Seq_HELA_Human4.22113690
3AR_21909140_ChIP-Seq_LNCAP_Human4.11994286
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.46212616
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.42683560
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.40663645
7HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.15999134
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.63957480
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.46018611
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.39433373
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.34295086
12* SMAD_19615063_ChIP-ChIP_OVARY_Human2.31328303
13CLOCK_20551151_ChIP-Seq_293T_Human2.30796715
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30599489
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27568254
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.25545926
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.24844300
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.21351781
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07015933
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04241922
21* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04241922
22AR_21572438_ChIP-Seq_LNCaP_Human2.03314463
23ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.96893666
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95997877
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94710754
26* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88740189
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87797399
28BRD4_25478319_ChIP-Seq_HGPS_Human1.85287212
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.81377489
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79988078
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.79270244
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.77869489
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.72136491
34* CJUN_26792858_Chip-Seq_BT549_Human1.71643084
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70089312
36ATF3_27146783_Chip-Seq_COLON_Human1.68141329
37* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67429342
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66420473
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63516949
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.61476310
41* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60835698
42TP53_18474530_ChIP-ChIP_U2OS_Human1.59425238
43* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54078666
44* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54045256
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53669002
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51407923
47FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.50804116
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.50496073
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50195605
50* LXR_22292898_ChIP-Seq_THP-1_Human1.47420701
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.44449097
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43698505
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43297397
54* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42502277
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41713663
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40428362
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37300899
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35872038
59* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.35716477
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35593205
61RUNX1_26923725_Chip-Seq_HPCs_Mouse1.34758436
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.34342062
63RACK7_27058665_Chip-Seq_MCF-7_Human1.34309129
64MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.34243653
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32245689
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32245689
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32174063
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.31358372
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31295303
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31295303
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.31217418
72* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30853905
73* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29687831
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29624013
75* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29575689
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29397397
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28258581
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28056400
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27215263
80* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26741822
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.25809862
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.25809862
83SA1_22415368_ChIP-Seq_MEFs_Mouse1.25411662
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25248519
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24358089
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.23991230
87* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23255053
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19012022
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16783241
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16184327
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16022647
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15138845
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.13246183
94LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12996075
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12994043
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.12836169
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12229796
98* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12114903
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10651564
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08979174
101* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08947014
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.08232935
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07896918
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07821473
105* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07331545
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07040124
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.06683229
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06517891
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.06476046
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.05511669
111* TP53_23651856_ChIP-Seq_MEFs_Mouse1.04118819
112KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03547910
113TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02986423
114EZH2_27294783_Chip-Seq_ESCs_Mouse1.02186113
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01653612
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01338851
117TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01091330
118* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00598967
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00364821
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98100308
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97460009
122* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96013486
123GF1B_26923725_Chip-Seq_HPCs_Mouse0.95956073
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95416416
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95002246
126MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94989916
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94556430
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93460601
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91774603
130PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91517390
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91288278
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89413924
133NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88884889
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88725388
135NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88628356
136JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87954514
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.86628951
138TP53_22127205_ChIP-Seq_IMR90_Human0.85572575
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84563448
140* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83519008
141TCF4_18268006_ChIP-ChIP_LS174T_Human0.82360037
142POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82330467
143* KDM2B_26808549_Chip-Seq_K562_Human0.81741774
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80952650
145ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80401006
146* NFYA_21822215_ChIP-Seq_K562_Human0.80276282
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79696410
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79662444
149CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79295939
150TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.79053283
151TP53_16413492_ChIP-PET_HCT116_Human0.78421850
152NFI_21473784_ChIP-Seq_ESCs_Mouse0.77726030
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.76754088
154* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.76610592
155NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76155503
156TP53_20018659_ChIP-ChIP_R1E_Mouse0.75789135
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75650914
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75650914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.44652378
2MP0003646_muscle_fatigue3.28960618
3MP0005503_abnormal_tendon_morphology3.25335015
4MP0003123_paternal_imprinting2.99392796
5MP0010030_abnormal_orbit_morphology2.92061234
6MP0003705_abnormal_hypodermis_morpholog2.84654972
7MP0002282_abnormal_trachea_morphology2.83271827
8MP0009250_abnormal_appendicular_skeleto2.79498210
9MP0002653_abnormal_ependyma_morphology2.43647696
10MP0009384_cardiac_valve_regurgitation2.40885813
11MP0003950_abnormal_plasma_membrane2.39484788
12MP0003718_maternal_effect2.39334574
13MP0001542_abnormal_bone_strength2.26697241
14MP0000163_abnormal_cartilage_morphology2.16744711
15MP0003283_abnormal_digestive_organ2.14420816
16MP0005508_abnormal_skeleton_morphology2.13996201
17MP0010368_abnormal_lymphatic_system2.11284782
18MP0003937_abnormal_limbs/digits/tail_de2.08992934
19MP0008877_abnormal_DNA_methylation2.07790314
20MP0004134_abnormal_chest_morphology2.03285277
21MP0002249_abnormal_larynx_morphology1.99508727
22MP0003755_abnormal_palate_morphology1.99156987
23MP0001299_abnormal_eye_distance/1.92182166
24MP0005451_abnormal_body_composition1.91635467
25MP0003111_abnormal_nucleus_morphology1.90107669
26MP0000767_abnormal_smooth_muscle1.89175974
27MP0003693_abnormal_embryo_hatching1.86876015
28MP0005257_abnormal_intraocular_pressure1.84252922
29MP0002115_abnormal_skeleton_extremities1.83164116
30MP0002933_joint_inflammation1.78987200
31MP0003121_genomic_imprinting1.78821774
32MP0005275_abnormal_skin_tensile1.78721424
33MP0003279_aneurysm1.76345750
34MP0002116_abnormal_craniofacial_bone1.72015229
35MP0006054_spinal_hemorrhage1.63365341
36MP0002113_abnormal_skeleton_development1.57782343
37MP0003385_abnormal_body_wall1.56913234
38MP0002109_abnormal_limb_morphology1.54431266
39MP0000432_abnormal_head_morphology1.53935193
40MP0001958_emphysema1.53231372
41MP0003077_abnormal_cell_cycle1.51968450
42MP0004272_abnormal_basement_membrane1.51922951
43MP0000049_abnormal_middle_ear1.50578421
44MP0002089_abnormal_postnatal_growth/wei1.49294931
45MP0010386_abnormal_urinary_bladder1.47912272
46MP0000013_abnormal_adipose_tissue1.47252701
47MP0004957_abnormal_blastocyst_morpholog1.47106083
48MP0009780_abnormal_chondrocyte_physiolo1.45026119
49MP0003942_abnormal_urinary_system1.44678559
50MP0000762_abnormal_tongue_morphology1.43302416
51MP0001348_abnormal_lacrimal_gland1.42986665
52MP0005395_other_phenotype1.40279465
53MP0005076_abnormal_cell_differentiation1.39958291
54MP0002896_abnormal_bone_mineralization1.38583454
55MP0000428_abnormal_craniofacial_morphol1.37147592
56MP0003935_abnormal_craniofacial_develop1.32194272
57MP0002932_abnormal_joint_morphology1.31122501
58MP0005377_hearing/vestibular/ear_phenot1.31120536
59MP0003878_abnormal_ear_physiology1.31120536
60MP0000534_abnormal_ureter_morphology1.28197118
61MP0001119_abnormal_female_reproductive1.28056938
62MP0009053_abnormal_anal_canal1.25983622
63MP0000003_abnormal_adipose_tissue1.23561705
64MP0002877_abnormal_melanocyte_morpholog1.22685771
65MP0002233_abnormal_nose_morphology1.22148202
66MP0003091_abnormal_cell_migration1.21431957
67MP0001661_extended_life_span1.21053176
68MP0002210_abnormal_sex_determination1.20000377
69MP0002085_abnormal_embryonic_tissue1.19571206
70MP0000579_abnormal_nail_morphology1.19212518
71MP0002084_abnormal_developmental_patter1.18692816
72MP0001915_intracranial_hemorrhage1.17873169
73MP0008932_abnormal_embryonic_tissue1.17191906
74MP0005023_abnormal_wound_healing1.13580133
75MP0003890_abnormal_embryonic-extraembry1.13350742
76MP0005390_skeleton_phenotype1.13178975
77MP0001730_embryonic_growth_arrest1.12835745
78MP0002114_abnormal_axial_skeleton1.12329626
79MP0000653_abnormal_sex_gland1.09653618
80MP0002111_abnormal_tail_morphology1.09290976
81MP0010094_abnormal_chromosome_stability1.09067025
82MP0008007_abnormal_cellular_replicative1.08152810
83MP0005595_abnormal_vascular_smooth1.06949095
84MP0000566_synostosis1.05551261
85MP0003787_abnormal_imprinting1.04663914
86MP0001697_abnormal_embryo_size1.04658234
87MP0000749_muscle_degeneration1.04268338
88MP0001879_abnormal_lymphatic_vessel1.04116332
89MP0003566_abnormal_cell_adhesion1.03957128
90MP0003699_abnormal_female_reproductive1.03816146
91MP0000462_abnormal_digestive_system1.03428578
92MP0002102_abnormal_ear_morphology1.02344476
93MP0002060_abnormal_skin_morphology1.01368543
94MP0003122_maternal_imprinting1.00571360
95MP0005193_abnormal_anterior_eye1.00164668
96MP0004197_abnormal_fetal_growth/weight/0.98609996
97MP0005197_abnormal_uvea_morphology0.97990027
98MP0000759_abnormal_skeletal_muscle0.96900702
99MP0002177_abnormal_outer_ear0.96808021
100MP0001849_ear_inflammation0.96234443
101MP0004233_abnormal_muscle_weight0.95788910
102MP0010352_gastrointestinal_tract_polyps0.95351151
103MP0001929_abnormal_gametogenesis0.94818146
104MP0000678_abnormal_parathyroid_gland0.94527755
105MP0000350_abnormal_cell_proliferation0.94104818
106MP0002108_abnormal_muscle_morphology0.93415016
107MP0005380_embryogenesis_phenotype0.92130051
108MP0001672_abnormal_embryogenesis/_devel0.92130051
109MP0000733_abnormal_muscle_development0.91109988
110MP0001145_abnormal_male_reproductive0.89475857
111MP0003115_abnormal_respiratory_system0.87361135
112MP0003119_abnormal_digestive_system0.87240096
113MP0004858_abnormal_nervous_system0.85994451
114MP0001243_abnormal_dermal_layer0.84212691
115MP0003941_abnormal_skin_development0.84160993
116MP0003795_abnormal_bone_structure0.83366377
117MP0000751_myopathy0.83187838
118MP0005623_abnormal_meninges_morphology0.82040638
119MP0005187_abnormal_penis_morphology0.80747413
120MP0000538_abnormal_urinary_bladder0.80458619
121MP0002295_abnormal_pulmonary_circulatio0.79429928
122MP0001270_distended_abdomen0.79405115
123MP0000750_abnormal_muscle_regeneration0.76253676
124MP0001614_abnormal_blood_vessel0.74523424
125MP0002128_abnormal_blood_circulation0.72090725
126MP0002168_other_aberrant_phenotype0.67353139
127MP0004087_abnormal_muscle_fiber0.62294113
128MP0003879_abnormal_hair_cell0.58909249
129MP0001756_abnormal_urination0.56888946
130MP0005670_abnormal_white_adipose0.56174962
131MP0005409_darkened_coat_color0.55849039
132MP0005375_adipose_tissue_phenotype0.55763881
133MP0005164_abnormal_response_to0.55314134
134MP0002998_abnormal_bone_remodeling0.53170183
135MP0001175_abnormal_lung_morphology0.51850543
136MP0002925_abnormal_cardiovascular_devel0.51518076
137MP0003959_abnormal_lean_body0.50446030
138MP0005369_muscle_phenotype0.50281695
139MP0003252_abnormal_bile_duct0.49382952
140MP0001340_abnormal_eyelid_morphology0.49322862
141MP0002697_abnormal_eye_size0.49160506
142MP0006138_congestive_heart_failure0.49112107

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)6.51426531
2Epiphyseal dysplasia (HP:0002656)6.04803627
3Vitreoretinal degeneration (HP:0000655)5.51596065
4Flat capital femoral epiphysis (HP:0003370)5.48325410
5Hypoplastic ischia (HP:0003175)4.50128906
6Neonatal short-limb short stature (HP:0008921)4.17556371
7Cupped ribs (HP:0000887)4.03781270
8Small epiphyses (HP:0010585)3.93853772
9Bladder diverticulum (HP:0000015)3.87574893
10Abnormality of the ischium (HP:0003174)3.83143154
11Protrusio acetabuli (HP:0003179)3.79603682
12Delayed epiphyseal ossification (HP:0002663)3.77358381
13Flat acetabular roof (HP:0003180)3.75079080
14Broad metatarsal (HP:0001783)3.73159468
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.72936413
16Abnormality of femoral epiphyses (HP:0006499)3.70348993
17Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.70348993
18Type 1 muscle fiber predominance (HP:0003803)3.63172957
19Genu varum (HP:0002970)3.54367978
20Wormian bones (HP:0002645)3.52779853
21Spinal rigidity (HP:0003306)3.51360650
22Atrophic scars (HP:0001075)3.50342227
23Cervical subluxation (HP:0003308)3.44806996
24Abnormality of the epiphysis of the femoral head (HP:0010574)3.43021487
25Premature rupture of membranes (HP:0001788)3.40117467
26Vertebral compression fractures (HP:0002953)3.34394686
27Abnormality of the proximal phalanges of the hand (HP:0009834)3.32519208
28Abnormal tarsal ossification (HP:0008369)3.29319771
29Mild short stature (HP:0003502)3.29060536
30Fragile skin (HP:0001030)3.25912328
31Spondylolisthesis (HP:0003302)3.21564138
32Blue sclerae (HP:0000592)3.15067907
33Slender build (HP:0001533)3.14927704
34Abnormality of the femoral head (HP:0003368)3.11659536
35Absent epiphyses (HP:0010577)3.08779833
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.08779833
37Hyperextensible skin (HP:0000974)3.00145647
38Osteoarthritis (HP:0002758)2.97666574
39Dilatation of the ascending aorta (HP:0005111)2.96059326
40Carpal bone hypoplasia (HP:0001498)2.96022220
41Metaphyseal cupping (HP:0003021)2.96012725
42Mitral valve prolapse (HP:0001634)2.89452452
43Bowel diverticulosis (HP:0005222)2.88543833
44Coronal craniosynostosis (HP:0004440)2.87685576
45Peritonitis (HP:0002586)2.87011371
46Coxa vara (HP:0002812)2.79538069
47Joint laxity (HP:0001388)2.76325488
48Flattened epiphyses (HP:0003071)2.75994507
49Biconcave vertebral bodies (HP:0004586)2.73982557
50Aortic regurgitation (HP:0001659)2.71358532
51Wrist flexion contracture (HP:0001239)2.65948526
52Metaphyseal irregularity (HP:0003025)2.64865160
53Increased variability in muscle fiber diameter (HP:0003557)2.61102076
54Partial duplication of the phalanx of hand (HP:0009999)2.60867496
55Ankle contracture (HP:0006466)2.58766580
56Short femoral neck (HP:0100864)2.58605536
57Elbow flexion contracture (HP:0002987)2.57536191
58Hypoventilation (HP:0002791)2.53031584
59Abnormal foot bone ossification (HP:0010675)2.51479824
60Abnormality of the pubic bones (HP:0003172)2.50250250
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.49684895
62Ulnar bowing (HP:0003031)2.49118974
63Genu recurvatum (HP:0002816)2.48840913
64Hypoplasia of the odontoid process (HP:0003311)2.48186478
65Limited elbow extension (HP:0001377)2.48089919
66Beaking of vertebral bodies (HP:0004568)2.45023375
67Thin ribs (HP:0000883)2.42159551
68Mitral regurgitation (HP:0001653)2.41326183
69Mildly elevated creatine phosphokinase (HP:0008180)2.40164358
70Wide anterior fontanel (HP:0000260)2.40013705
71Shallow orbits (HP:0000586)2.39807636
72Cerebral aneurysm (HP:0004944)2.38695359
73Abnormality of the acetabulum (HP:0003170)2.34668913
74Platyspondyly (HP:0000926)2.34625642
75Hip contracture (HP:0003273)2.33469001
76Thoracolumbar scoliosis (HP:0002944)2.29711802
77Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.27246041
78Broad thumb (HP:0011304)2.26749949
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26232472
80Broad long bones (HP:0005622)2.20938225
81Turricephaly (HP:0000262)2.20828510
82Congenital glaucoma (HP:0001087)2.19662336
83Abnormality of the vertebral endplates (HP:0005106)2.19434027
84Disproportionate tall stature (HP:0001519)2.19028874
85Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.18632041
86Aortic valve stenosis (HP:0001650)2.17896783
87Abnormal delivery (HP:0001787)2.17865915
88Abnormal vertebral ossification (HP:0100569)2.17293735
89Spinal cord compression (HP:0002176)2.15589221
90Exostoses (HP:0100777)2.15567448
91Renal duplication (HP:0000075)2.15452495
92Short nail (HP:0001799)2.15187635
93Mesomelia (HP:0003027)2.14949243
94Hypoplastic iliac wings (HP:0002866)2.14804435
95Limited hip movement (HP:0008800)2.13920040
96Aneurysm (HP:0002617)2.13596385
97Broad phalanx (HP:0006009)2.13047756
98Long toe (HP:0010511)2.12490112
99Arterial tortuosity (HP:0005116)2.09321484
100Abnormality of skeletal muscle fiber size (HP:0012084)2.09138365
101Round ear (HP:0100830)2.08808964
102Vascular tortuosity (HP:0004948)2.08761025
103Follicular hyperkeratosis (HP:0007502)2.07949069
104Abnormality of the odontoid process (HP:0003310)2.07186993
105Stillbirth (HP:0003826)2.06780610
106Adrenal hypoplasia (HP:0000835)2.06665280
107Mitral stenosis (HP:0001718)2.06380072
108Male infertility (HP:0003251)2.06185743
109Osteolytic defects of the hand bones (HP:0009699)2.05602565
110Osteolytic defects of the phalanges of the hand (HP:0009771)2.05602565
111Soft skin (HP:0000977)2.05439029
112Aortic dissection (HP:0002647)2.04252727
113Camptodactyly of toe (HP:0001836)2.04216891
114Ectopia lentis (HP:0001083)2.03775691
115Arthropathy (HP:0003040)2.02453779
116Barrel-shaped chest (HP:0001552)2.01750436
117Aplasia/hypoplasia of the femur (HP:0005613)2.00232713
118Aplasia of the musculature (HP:0100854)1.99983243
119Disproportionate short-trunk short stature (HP:0003521)1.99749553
120Natal tooth (HP:0000695)1.99229516
121Aplasia involving bones of the upper limbs (HP:0009823)1.99177507
122Aplasia of the phalanges of the hand (HP:0009802)1.99177507
123Aplasia involving bones of the extremities (HP:0009825)1.99177507
124Obstructive sleep apnea (HP:0002870)1.98396897
125Abnormality of the phalanges of the hallux (HP:0010057)1.98374033
126Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.98358953
127Absent frontal sinuses (HP:0002688)1.97839118
128Deviation of the hallux (HP:0010051)1.97480189
129Hypoplastic ilia (HP:0000946)1.97415700
130Increased connective tissue (HP:0009025)1.94715704
131Nuclear cataract (HP:0100018)1.93433088
132Generalized amyotrophy (HP:0003700)1.92927061
133Infantile muscular hypotonia (HP:0008947)1.92331619
134Rhizomelia (HP:0008905)1.91685998
135Abnormality of the 2nd finger (HP:0004100)1.90757257
136Overgrowth (HP:0001548)1.90722438
137Abnormality of incisor morphology (HP:0011063)1.90255125
138Abnormality of the phalanges of the 5th finger (HP:0004213)1.89246036
139Abnormality of carpal bone ossification (HP:0006257)1.89045035
140Hypoplastic pelvis (HP:0008839)1.88997974
141Spinal cord lesions (HP:0100561)1.88746709
142Syringomyelia (HP:0003396)1.88746709
143Fibular hypoplasia (HP:0003038)1.87499451
144Abnormal hand bone ossification (HP:0010660)1.87274859
145Hallux valgus (HP:0001822)1.87038737
146Protuberant abdomen (HP:0001538)1.86836773
147Delayed cranial suture closure (HP:0000270)1.85927411
148Abnormality of the radial head (HP:0003995)1.84712450
149Short 5th finger (HP:0009237)1.84689319
150Irregular vertebral endplates (HP:0003301)1.84430282
151Waddling gait (HP:0002515)1.83560152
152Abnormality of dentin (HP:0010299)1.82107229
153Broad phalanges of the hand (HP:0009768)1.81932966
154Cardiovascular calcification (HP:0011915)1.81819437
155Abnormal ossification of hand bones (HP:0005921)1.81742802
156Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.81131023
157Joint stiffness (HP:0001387)1.81122457
158Aortic aneurysm (HP:0004942)1.80743206
159Narrow palate (HP:0000189)1.80705244
160Bell-shaped thorax (HP:0001591)1.79496659
161Reduced subcutaneous adipose tissue (HP:0003758)1.79485988
162Protruding ear (HP:0000411)1.78781463
163Hypoplasia of the iris (HP:0007676)1.77961083
164Hand muscle atrophy (HP:0009130)1.77640621
165Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76772685
166Achilles tendon contracture (HP:0001771)1.74998610
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.74992501
168Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.74319210
169Shawl scrotum (HP:0000049)1.74252457
170Synostosis of carpal bones (HP:0005048)1.73993682
171Partial duplication of thumb phalanx (HP:0009944)1.73289008
172Ovoid vertebral bodies (HP:0003300)1.73276172
173Metaphyseal dysplasia (HP:0100255)1.72776174
174Broad finger (HP:0001500)1.72631646
175Inguinal hernia (HP:0000023)1.72538876
176Buphthalmos (HP:0000557)1.71201220
177Breech presentation (HP:0001623)1.70381257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.53774702
2STK38L5.26459661
3LATS25.23673491
4MYLK4.73022660
5DDR23.42101789
6TTN2.95514088
7PLK42.89225693
8ERBB42.69624890
9TAOK12.66621446
10NTRK12.62577271
11PAK22.58115791
12CDK122.40938805
13CDC72.35660201
14MAP3K32.30661545
15AKT32.25896963
16PRKD32.18874455
17LIMK12.07201757
18STK32.07135742
19TESK12.01572255
20RIPK11.93214891
21MOS1.91890926
22MAP3K61.91354565
23TGFBR21.89332523
24MET1.87739240
25TTK1.84921392
26SIK11.81847553
27ERN11.75900669
28TRIB31.66702596
29MELK1.57317677
30NEK91.56288855
31BRAF1.50821304
32CDK91.43704131
33BUB11.41886330
34EEF2K1.41676002
35ICK1.40239980
36KSR21.38364283
37NEK21.37854294
38CDK81.33217081
39WNK31.31483945
40PAK41.25967446
41PTK2B1.25920180
42FLT31.19564526
43ILK1.17516591
44CHEK21.16313558
45PLK11.12137136
46MAP3K91.09280609
47PKN21.09250565
48STK241.06072568
49EPHA31.04554229
50MAPKAPK31.03287278
51MAPK71.02352895
52STK101.02242182
53PRKD21.01272758
54STK381.00389698
55RPS6KA21.00339903
56PIM20.98979137
57BRSK10.95654939
58ROCK20.95058972
59RAF10.93567027
60DYRK20.93202268
61ADRBK10.93106756
62PIK3CG0.90086487
63MAP3K40.88666230
64DAPK30.87935996
65LMTK20.87711454
66CAMK1G0.86187343
67DMPK0.84041255
68CDK70.83834663
69PAK60.83072043
70PRKG20.81556418
71NLK0.81452405
72TAOK30.80447941
73MAP3K80.79953365
74ABL20.78207414
75MAP2K10.76514561
76MTOR0.76117330
77AURKB0.75354988
78PLK20.74635568
79NUAK10.74375524
80BRSK20.73901252
81PLK30.73658131
82AURKA0.70250388
83CAMK2B0.69900858
84KSR10.69085778
85IRAK30.68424257
86ARAF0.68230159
87PTK20.68196730
88CHEK10.67669094
89BMPR20.67203618
90EPHB10.66262658
91EPHA20.65996325
92CDC42BPA0.64061699
93PNCK0.63905199
94NME10.63410683
95PDGFRA0.62888194
96WNK40.60912628
97SMG10.60523890
98MAP3K130.60264424
99GSK3A0.59977937
100BRD40.58158633
101TRPM70.57675207
102CAMK2G0.57277217
103MAPK110.55427458
104MAP2K30.54706814
105SGK20.54284874
106RPS6KA40.54046799
107EPHB20.53685576
108ATM0.53449754
109ROCK10.53360205
110PDPK10.52535373
111CDK40.50106848
112PRKCH0.49786544
113PRPF4B0.49388247
114GRK50.49279053
115DYRK1A0.47149435
116MUSK0.45040687
117PRKD10.43726723
118RPS6KL10.42246532
119RPS6KC10.42246532
120KIT0.42051145
121CDK10.41324911
122TAOK20.40889669
123CSNK1G10.40071183
124MAPK40.39434659
125CDK20.39238495
126PAK30.37264480
127PAK10.36732062
128TYRO30.36569373
129MAP3K50.35976606
130MAP3K70.35746186
131SGK30.35159333
132SGK2230.35002793
133SGK4940.35002793
134MST1R0.31847152
135MAPK130.31043028
136MARK10.30889785
137CAMK10.30661480
138PRKAA10.30426020
139CDK11A0.30420453
140MAPK10.29978590
141BMX0.29770944
142PDGFRB0.29257894
143RPS6KA60.29226002
144AKT10.29183629
145CDK150.28628122
146MAPKAPK50.28247510
147RET0.28056094
148CLK10.27821579
149MARK20.26616678
150MAPK140.26273759
151SRC0.25640130
152MAPKAPK20.25569105
153GRK70.25364831
154CSNK1A1L0.25354982
155ATR0.24571223
156MKNK20.22875551
157ABL10.22223617
158WNK10.22180935
159PRKCI0.22030583

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.63294132
2ECM-receptor interaction_Homo sapiens_hsa045123.21403000
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.89606536
4TGF-beta signaling pathway_Homo sapiens_hsa043502.75242765
5Protein digestion and absorption_Homo sapiens_hsa049742.67693415
6Basal transcription factors_Homo sapiens_hsa030222.46277874
7RNA transport_Homo sapiens_hsa030132.20731468
8p53 signaling pathway_Homo sapiens_hsa041152.18825768
9RNA degradation_Homo sapiens_hsa030182.16151730
10Hippo signaling pathway_Homo sapiens_hsa043902.14476208
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13070289
12MicroRNAs in cancer_Homo sapiens_hsa052061.97140646
13Lysine degradation_Homo sapiens_hsa003101.90895971
14Bladder cancer_Homo sapiens_hsa052191.90833857
15Basal cell carcinoma_Homo sapiens_hsa052171.90360394
16Hedgehog signaling pathway_Homo sapiens_hsa043401.89077586
17Dilated cardiomyopathy_Homo sapiens_hsa054141.83441892
18Adherens junction_Homo sapiens_hsa045201.79551846
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.76872245
20Ovarian steroidogenesis_Homo sapiens_hsa049131.76217383
21Focal adhesion_Homo sapiens_hsa045101.70038942
22Circadian rhythm_Homo sapiens_hsa047101.60365497
23Pancreatic cancer_Homo sapiens_hsa052121.58285149
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51683011
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48576518
26Oocyte meiosis_Homo sapiens_hsa041141.48255981
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43652678
28RNA polymerase_Homo sapiens_hsa030201.36074461
29Thyroid cancer_Homo sapiens_hsa052161.36003887
30Dorso-ventral axis formation_Homo sapiens_hsa043201.30499977
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29555383
32Fanconi anemia pathway_Homo sapiens_hsa034601.26893473
33Gap junction_Homo sapiens_hsa045401.24563953
34Wnt signaling pathway_Homo sapiens_hsa043101.21454134
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20780254
36Proteoglycans in cancer_Homo sapiens_hsa052051.20574665
37Homologous recombination_Homo sapiens_hsa034401.20278139
38mRNA surveillance pathway_Homo sapiens_hsa030151.18902471
39Colorectal cancer_Homo sapiens_hsa052101.13987978
40Notch signaling pathway_Homo sapiens_hsa043301.11843211
41Melanoma_Homo sapiens_hsa052181.10440982
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10093548
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09679792
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.07185962
45Base excision repair_Homo sapiens_hsa034101.06959718
46Prostate cancer_Homo sapiens_hsa052151.06766875
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.06660617
48Nucleotide excision repair_Homo sapiens_hsa034201.05933179
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05783435
50One carbon pool by folate_Homo sapiens_hsa006701.04807438
51Axon guidance_Homo sapiens_hsa043601.04083492
52DNA replication_Homo sapiens_hsa030301.03100019
53Small cell lung cancer_Homo sapiens_hsa052221.02739770
54Renal cell carcinoma_Homo sapiens_hsa052110.99760609
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97078806
56HTLV-I infection_Homo sapiens_hsa051660.96166671
57FoxO signaling pathway_Homo sapiens_hsa040680.96150598
58Endometrial cancer_Homo sapiens_hsa052130.92500119
59mTOR signaling pathway_Homo sapiens_hsa041500.91685006
60Non-homologous end-joining_Homo sapiens_hsa034500.91292436
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91179879
62Sphingolipid metabolism_Homo sapiens_hsa006000.90946370
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89951926
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88808606
65Chronic myeloid leukemia_Homo sapiens_hsa052200.86983241
66Other glycan degradation_Homo sapiens_hsa005110.85965429
67Folate biosynthesis_Homo sapiens_hsa007900.81946986
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81138857
69Choline metabolism in cancer_Homo sapiens_hsa052310.78537928
70Glioma_Homo sapiens_hsa052140.74673908
71Vibrio cholerae infection_Homo sapiens_hsa051100.74171345
72Prion diseases_Homo sapiens_hsa050200.73919191
73Pathways in cancer_Homo sapiens_hsa052000.73378342
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73332817
75Arginine and proline metabolism_Homo sapiens_hsa003300.72499804
76N-Glycan biosynthesis_Homo sapiens_hsa005100.72088185
77Tight junction_Homo sapiens_hsa045300.71316010
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71000704
79Cocaine addiction_Homo sapiens_hsa050300.70881735
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68499685
81ErbB signaling pathway_Homo sapiens_hsa040120.68474505
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68049465
83Endocytosis_Homo sapiens_hsa041440.67868763
84Galactose metabolism_Homo sapiens_hsa000520.67068017
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.66888281
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.66800024
87Prolactin signaling pathway_Homo sapiens_hsa049170.66708359
88GnRH signaling pathway_Homo sapiens_hsa049120.66137946
89Calcium signaling pathway_Homo sapiens_hsa040200.64473492
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64045138
91Sulfur relay system_Homo sapiens_hsa041220.63770083
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61128510
93Long-term potentiation_Homo sapiens_hsa047200.60269724
94Pentose phosphate pathway_Homo sapiens_hsa000300.59831174
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59745301
96Hepatitis B_Homo sapiens_hsa051610.58129466
97Spliceosome_Homo sapiens_hsa030400.57088588
98Thyroid hormone synthesis_Homo sapiens_hsa049180.56989914
99Inositol phosphate metabolism_Homo sapiens_hsa005620.56399863
100Vitamin B6 metabolism_Homo sapiens_hsa007500.53696686
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53391709
102Ras signaling pathway_Homo sapiens_hsa040140.53009534
103Rap1 signaling pathway_Homo sapiens_hsa040150.52208318
104Non-small cell lung cancer_Homo sapiens_hsa052230.52139702
105Fructose and mannose metabolism_Homo sapiens_hsa000510.50705891
106Renin secretion_Homo sapiens_hsa049240.50502263
107MAPK signaling pathway_Homo sapiens_hsa040100.49511615
108Protein export_Homo sapiens_hsa030600.49365705
109Malaria_Homo sapiens_hsa051440.49093021
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48303941
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47945166
112Insulin secretion_Homo sapiens_hsa049110.47799883
113Melanogenesis_Homo sapiens_hsa049160.47330870
114cAMP signaling pathway_Homo sapiens_hsa040240.47274547
115Cholinergic synapse_Homo sapiens_hsa047250.47128357
116Amoebiasis_Homo sapiens_hsa051460.45661547
117Pyrimidine metabolism_Homo sapiens_hsa002400.45575841
118Oxytocin signaling pathway_Homo sapiens_hsa049210.42696701
119Linoleic acid metabolism_Homo sapiens_hsa005910.42634749
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42274090
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42195304
122Glucagon signaling pathway_Homo sapiens_hsa049220.41865367
123VEGF signaling pathway_Homo sapiens_hsa043700.41608512
124AMPK signaling pathway_Homo sapiens_hsa041520.41164280
125Mismatch repair_Homo sapiens_hsa034300.40042376
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38801112
127Long-term depression_Homo sapiens_hsa047300.38653739
128TNF signaling pathway_Homo sapiens_hsa046680.38355301
129Shigellosis_Homo sapiens_hsa051310.38094230
130Viral carcinogenesis_Homo sapiens_hsa052030.38071610
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.36853154
132Glutamatergic synapse_Homo sapiens_hsa047240.36391373
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36212630
134HIF-1 signaling pathway_Homo sapiens_hsa040660.35889694
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35868069
136Epstein-Barr virus infection_Homo sapiens_hsa051690.32509022
137Estrogen signaling pathway_Homo sapiens_hsa049150.32201347
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.30087786
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.29707520

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