GLIS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.09364281
2regulation of hippo signaling (GO:0035330)4.41673788
3protein heterotrimerization (GO:0070208)4.29619161
4bone trabecula formation (GO:0060346)4.18299565
5hippo signaling (GO:0035329)4.09473765
6polarized epithelial cell differentiation (GO:0030859)4.06490117
7chondrocyte proliferation (GO:0035988)3.94543868
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.88397379
9atrioventricular valve morphogenesis (GO:0003181)3.72109245
10metanephric mesenchyme development (GO:0072075)3.67253705
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.63458124
12metanephric nephron tubule development (GO:0072234)3.61163149
13metanephric tubule development (GO:0072170)3.61163149
14metanephric nephron epithelium development (GO:0072243)3.57600938
15kidney mesenchyme development (GO:0072074)3.54498070
16glomerular basement membrane development (GO:0032836)3.52552194
17protein retention in ER lumen (GO:0006621)3.50551065
18metanephric epithelium development (GO:0072207)3.49195276
19collecting duct development (GO:0072044)3.45065574
20collagen fibril organization (GO:0030199)3.44493724
21semaphorin-plexin signaling pathway (GO:0071526)3.37237199
22outer ear morphogenesis (GO:0042473)3.34432742
23renal filtration (GO:0097205)3.31355275
24epithelial cell-cell adhesion (GO:0090136)3.28556295
25mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.24487256
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23723191
27cell proliferation involved in metanephros development (GO:0072203)3.22465867
28establishment of apical/basal cell polarity (GO:0035089)3.16687817
29skin morphogenesis (GO:0043589)3.15466044
30basement membrane organization (GO:0071711)3.14512362
31regulation of SMAD protein import into nucleus (GO:0060390)3.14286274
32axon extension involved in axon guidance (GO:0048846)3.12428734
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.12428734
34negative regulation of chondrocyte differentiation (GO:0032331)3.11564190
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.09391491
36cochlea morphogenesis (GO:0090103)3.05695419
37mesenchyme development (GO:0060485)3.03696214
38lung-associated mesenchyme development (GO:0060484)3.01488516
39branching involved in salivary gland morphogenesis (GO:0060445)3.01250890
40cell migration involved in heart development (GO:0060973)3.00479822
41vascular endothelial growth factor signaling pathway (GO:0038084)2.99997838
42regulation of posttranscriptional gene silencing (GO:0060147)2.96686766
43regulation of gene silencing by miRNA (GO:0060964)2.96686766
44regulation of gene silencing by RNA (GO:0060966)2.96686766
45glomerular filtration (GO:0003094)2.94032874
46endothelial cell chemotaxis (GO:0035767)2.93119879
47sequestering of extracellular ligand from receptor (GO:0035581)2.89257560
48dermatan sulfate metabolic process (GO:0030205)2.89075996
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.88941181
50notochord development (GO:0030903)2.88687682
51extracellular matrix assembly (GO:0085029)2.87647446
52type B pancreatic cell proliferation (GO:0044342)2.87607061
53nephron tubule development (GO:0072080)2.87077063
54Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.86972265
55cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.84925644
56endocardial cushion development (GO:0003197)2.84862229
57focal adhesion assembly (GO:0048041)2.81800156
58cell-substrate adherens junction assembly (GO:0007045)2.81800156
59negative regulation of axon extension involved in axon guidance (GO:0048843)2.79890495
60positive regulation of SMAD protein import into nucleus (GO:0060391)2.79099994
61anatomical structure regression (GO:0060033)2.77402495
62regulation of establishment of planar polarity (GO:0090175)2.76201637
63cell-cell junction maintenance (GO:0045217)2.76173172
64positive regulation of protein kinase C signaling (GO:0090037)2.76021593
65endodermal cell differentiation (GO:0035987)2.75518789
66regulation of axon extension involved in axon guidance (GO:0048841)2.75142604
67adherens junction assembly (GO:0034333)2.74352122
68cell-substrate junction assembly (GO:0007044)2.73819818
69non-canonical Wnt signaling pathway (GO:0035567)2.73202519
70convergent extension (GO:0060026)2.72760752
71negative regulation of catenin import into nucleus (GO:0035414)2.72586466
72myelination in peripheral nervous system (GO:0022011)2.70764359
73peripheral nervous system axon ensheathment (GO:0032292)2.70764359
74insulin-like growth factor receptor signaling pathway (GO:0048009)2.69779342
75dermatan sulfate biosynthetic process (GO:0030208)2.68836995
76nephron epithelium morphogenesis (GO:0072088)2.68287753
77nephron tubule morphogenesis (GO:0072078)2.68287753
78negative regulation of cartilage development (GO:0061037)2.68206720
79lateral sprouting from an epithelium (GO:0060601)2.66343137
80collagen metabolic process (GO:0032963)2.65412811
81axon extension (GO:0048675)2.64773090
82cell proliferation involved in kidney development (GO:0072111)2.64602522
83positive regulation of catenin import into nucleus (GO:0035413)2.64440143
84cell surface receptor signaling pathway involved in heart development (GO:0061311)2.64315582
85nephron epithelium development (GO:0072009)2.63382079
86aminoglycoside antibiotic metabolic process (GO:0030647)2.63349954
87peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.63191554
88establishment or maintenance of monopolar cell polarity (GO:0061339)2.63004982
89establishment of monopolar cell polarity (GO:0061162)2.63004982
90cellular response to vitamin D (GO:0071305)2.62426639
91UV protection (GO:0009650)2.60651060
92embryonic camera-type eye development (GO:0031076)2.60235076
93renal tubule morphogenesis (GO:0061333)2.59929748
94vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.58816235
95craniofacial suture morphogenesis (GO:0097094)2.58229588
96regulation of cell fate specification (GO:0042659)2.57921940
97renal tubule development (GO:0061326)2.57805258
98virion attachment to host cell (GO:0019062)2.57705626
99adhesion of symbiont to host cell (GO:0044650)2.57705626
100regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57245668
101regulation of heart morphogenesis (GO:2000826)2.57177916
102tooth mineralization (GO:0034505)2.56467131
103regulation of catenin import into nucleus (GO:0035412)2.56463564
104cellular response to vitamin (GO:0071295)2.55570627
105anterior/posterior axis specification, embryo (GO:0008595)2.55463181
106positive regulation of osteoblast proliferation (GO:0033690)2.55102322
107mesenchymal-epithelial cell signaling (GO:0060638)2.54941460
108wound healing, spreading of epidermal cells (GO:0035313)2.53928490
109collagen catabolic process (GO:0030574)2.53815371
110cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.52641325
111camera-type eye morphogenesis (GO:0048593)2.51731722
112G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.50735734
113pattern specification involved in kidney development (GO:0061004)2.50211750
114extracellular fibril organization (GO:0043206)2.49282174
115regulation of gastrulation (GO:0010470)2.49216990
116embryonic foregut morphogenesis (GO:0048617)2.48966037
117phosphate ion transport (GO:0006817)2.48926503
118cytoskeletal anchoring at plasma membrane (GO:0007016)2.48445336
119positive regulation of epithelial to mesenchymal transition (GO:0010718)2.48021545
120regulation of stem cell maintenance (GO:2000036)2.47854600
121retina vasculature morphogenesis in camera-type eye (GO:0061299)2.47619140
122multicellular organismal macromolecule metabolic process (GO:0044259)2.47262284
123mesenchymal cell proliferation (GO:0010463)2.46815191
124Notch signaling involved in heart development (GO:0061314)2.46705746
125negative regulation of fatty acid transport (GO:2000192)2.45976560
126hemidesmosome assembly (GO:0031581)2.45143649
127negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.45106872
128negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.43534623
129stress fiber assembly (GO:0043149)2.43429171
130regulation of axon guidance (GO:1902667)2.43211322
131atrial septum morphogenesis (GO:0060413)2.42653988
132establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.42249580
133endothelial cell morphogenesis (GO:0001886)2.41426020
134nephron tubule formation (GO:0072079)2.40227597
135cell migration involved in sprouting angiogenesis (GO:0002042)2.40022651
136proximal/distal pattern formation (GO:0009954)2.39610968
137renal system development (GO:0072001)2.39302644
138adhesion of symbiont to host (GO:0044406)2.38821942
139organ induction (GO:0001759)2.38802987
140eye morphogenesis (GO:0048592)2.38234003
141outflow tract septum morphogenesis (GO:0003148)2.37803722
142gonadal mesoderm development (GO:0007506)2.36925131
143extracellular matrix disassembly (GO:0022617)2.35226853
144urogenital system development (GO:0001655)2.31167667
145urinary tract smooth muscle contraction (GO:0014848)2.30831118
146multicellular organismal metabolic process (GO:0044236)2.30037850
147multicellular organismal catabolic process (GO:0044243)2.29983909
148bone development (GO:0060348)2.29842906
149substrate-dependent cell migration (GO:0006929)2.29680380
150negative regulation of axon guidance (GO:1902668)2.29678898
151regulation of early endosome to late endosome transport (GO:2000641)2.29589031
152endocytic recycling (GO:0032456)2.27401457
153extracellular matrix organization (GO:0030198)2.26954452
154positive regulation of blood vessel endothelial cell migration (GO:0043536)2.26392291
155growth hormone secretion (GO:0030252)2.26285843
156neuron projection extension (GO:1990138)2.26205433
157extracellular structure organization (GO:0043062)2.25973206
158aorta morphogenesis (GO:0035909)2.25886331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.10597292
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.57129358
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.49851970
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.75645911
5CLOCK_20551151_ChIP-Seq_293T_Human2.72052907
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.58703599
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.57902554
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.54147840
9* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.51613779
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.44911944
11ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.39390492
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.28756918
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21218138
14* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.17550226
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.11358410
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.05560216
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04488780
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03353825
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.02220226
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00428961
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97225801
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96285284
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96285284
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96285284
25* CTCF_27219007_Chip-Seq_Bcells_Human1.91188327
26* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.87010147
27* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83066010
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.82210056
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.80884924
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.75940885
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.74503127
32EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.73786785
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72560265
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72560265
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.72523390
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71908391
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.67413042
38AR_21909140_ChIP-Seq_LNCAP_Human1.67156713
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.66093684
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65939991
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.64933241
42P68_20966046_ChIP-Seq_HELA_Human1.64291297
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.63669532
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.63021998
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61915250
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61712754
47ZNF263_19887448_ChIP-Seq_K562_Human1.60829336
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.60618516
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60517604
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.54082554
51* KDM2B_26808549_Chip-Seq_DND41_Human1.54039369
52* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53617546
53NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53102832
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.52755597
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52456756
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50986857
57* TET1_21451524_ChIP-Seq_MESCs_Mouse1.50339135
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.50096326
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49960669
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49839034
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49428692
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.49274063
63* VDR_21846776_ChIP-Seq_THP-1_Human1.48916000
64* RACK7_27058665_Chip-Seq_MCF-7_Human1.48906294
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.48887577
66TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46302870
67BRD4_25478319_ChIP-Seq_HGPS_Human1.45946488
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45375064
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45112018
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.44747773
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44638226
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44608530
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44591914
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44548761
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44081506
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43316733
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.42700079
78MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.41683240
79* SMC4_20622854_ChIP-Seq_HELA_Human1.41082997
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37008149
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36872809
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36479724
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35427792
84* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.34788605
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33189809
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32017467
87* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30989960
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30350778
89* RING1B_27294783_Chip-Seq_NPCs_Mouse1.29429558
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29078358
91TET1_21490601_ChIP-Seq_MESCs_Mouse1.29019718
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.28311828
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28287573
94* KDM2B_26808549_Chip-Seq_K562_Human1.28263510
95TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.28014389
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27613813
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27553261
98* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27037187
99ATF3_27146783_Chip-Seq_COLON_Human1.26335625
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25826523
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25531053
102CJUN_26792858_Chip-Seq_BT549_Human1.25104086
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25062760
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24568210
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24565647
106* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24453400
107UBF1/2_26484160_Chip-Seq_HMECs_Human1.24085639
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23859853
109POU5F1_16518401_ChIP-PET_MESCs_Mouse1.22498475
110* KDM2B_26808549_Chip-Seq_JURKAT_Human1.21792347
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21759607
112TP53_22127205_ChIP-Seq_IMR90_Human1.21585085
113* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21414888
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20151599
115* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18547320
116TP53_23651856_ChIP-Seq_MEFs_Mouse1.17679783
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17340565
118SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16476926
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15869197
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14977710
121RUNX1_27514584_Chip-Seq_MCF-7_Human1.13892452
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13718924
123JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13556881
124TBX20_22328084_ChIP-Seq_HEART_Mouse1.13221907
125TBX20_22080862_ChIP-Seq_HEART_Mouse1.13221907
126RING1B_27294783_Chip-Seq_ESCs_Mouse1.13149735
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12457916
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11157509
129NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11116646
130SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09310266
131NANOG_16153702_ChIP-ChIP_HESCs_Human1.09244313
132CREB1_26743006_Chip-Seq_LNCaP_Human1.09162765
133IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08138104
134* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06923987
135LXR_22292898_ChIP-Seq_THP-1_Human1.06200435
136* TCF7_22412390_ChIP-Seq_EML_Mouse1.04988032
137NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04952741
138* RARB_24833708_ChIP-Seq_LIVER_Mouse1.04882742
139CHD1_26751641_Chip-Seq_LNCaP_Human1.04770523
140KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03924522
141* TP63_22573176_ChIP-Seq_HFKS_Human1.03210389
142SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01565442
143SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01539910
144ERG_21242973_ChIP-ChIP_JURKAT_Human1.01459966
145* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01345929
146RARA_24833708_ChIP-Seq_LIVER_Mouse1.01127761
147CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00521530
148KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00474274
149PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00110670
150WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99602759
151* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99408158
152* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98968401
153POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98896122
154JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98890206
155SA1_22415368_ChIP-Seq_MEFs_Mouse0.97873072

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.23381865
2MP0005503_abnormal_tendon_morphology3.59314913
3MP0010030_abnormal_orbit_morphology3.28546225
4MP0004272_abnormal_basement_membrane2.86122372
5MP0003705_abnormal_hypodermis_morpholog2.85678639
6MP0001958_emphysema2.84255162
7MP0005623_abnormal_meninges_morphology2.74345577
8MP0005275_abnormal_skin_tensile2.64275811
9MP0003283_abnormal_digestive_organ2.35735027
10MP0003279_aneurysm2.25275303
11MP0005409_darkened_coat_color2.13156029
12MP0005171_absent_coat_pigmentation2.02878313
13MP0000537_abnormal_urethra_morphology1.95566767
14MP0000534_abnormal_ureter_morphology1.92861412
15MP0003942_abnormal_urinary_system1.90225459
16MP0003385_abnormal_body_wall1.87602187
17MP0009053_abnormal_anal_canal1.80832356
18MP0000013_abnormal_adipose_tissue1.77114030
19MP0003941_abnormal_skin_development1.75866185
20MP0005508_abnormal_skeleton_morphology1.73063541
21MP0003115_abnormal_respiratory_system1.73016880
22MP0005423_abnormal_somatic_nervous1.69194234
23MP0000733_abnormal_muscle_development1.66537002
24MP0009384_cardiac_valve_regurgitation1.65824176
25MP0000428_abnormal_craniofacial_morphol1.63142588
26MP0003136_yellow_coat_color1.62532326
27MP0003878_abnormal_ear_physiology1.62278490
28MP0005377_hearing/vestibular/ear_phenot1.62278490
29MP0004233_abnormal_muscle_weight1.57672737
30MP0002653_abnormal_ependyma_morphology1.54693283
31MP0009250_abnormal_appendicular_skeleto1.53550550
32MP0002108_abnormal_muscle_morphology1.53117234
33MP0002932_abnormal_joint_morphology1.50325535
34MP0003122_maternal_imprinting1.50057444
35MP0000049_abnormal_middle_ear1.50024085
36MP0004858_abnormal_nervous_system1.49930892
37MP0002060_abnormal_skin_morphology1.47208832
38MP0000003_abnormal_adipose_tissue1.45812833
39MP0003119_abnormal_digestive_system1.43659912
40MP0009780_abnormal_chondrocyte_physiolo1.43635644
41MP0001348_abnormal_lacrimal_gland1.41777829
42MP0001542_abnormal_bone_strength1.39693252
43MP0002295_abnormal_pulmonary_circulatio1.39174226
44MP0003755_abnormal_palate_morphology1.37801353
45MP0003935_abnormal_craniofacial_develop1.35748380
46MP0002249_abnormal_larynx_morphology1.35598596
47MP0003566_abnormal_cell_adhesion1.35283879
48MP0003937_abnormal_limbs/digits/tail_de1.33889058
49MP0002896_abnormal_bone_mineralization1.33153078
50MP0002282_abnormal_trachea_morphology1.31516020
51MP0006054_spinal_hemorrhage1.30944309
52MP0005076_abnormal_cell_differentiation1.29793993
53MP0005257_abnormal_intraocular_pressure1.29740366
54MP0001293_anophthalmia1.27904394
55MP0004133_heterotaxia1.26795796
56MP0010352_gastrointestinal_tract_polyps1.25936278
57MP0002116_abnormal_craniofacial_bone1.25915240
58MP0010368_abnormal_lymphatic_system1.25442088
59MP0000432_abnormal_head_morphology1.25142780
60MP0002697_abnormal_eye_size1.23375409
61MP0003123_paternal_imprinting1.23348285
62MP0000762_abnormal_tongue_morphology1.23031945
63MP0001299_abnormal_eye_distance/1.20401897
64MP0003091_abnormal_cell_migration1.19338815
65MP0002084_abnormal_developmental_patter1.16925340
66MP0003567_abnormal_fetal_cardiomyocyte1.16766872
67MP0000163_abnormal_cartilage_morphology1.16434621
68MP0004197_abnormal_fetal_growth/weight/1.16104891
69MP0001849_ear_inflammation1.15843657
70MP0002085_abnormal_embryonic_tissue1.14258846
71MP0000751_myopathy1.10626575
72MP0002092_abnormal_eye_morphology1.08881816
73MP0002089_abnormal_postnatal_growth/wei1.08572627
74MP0000767_abnormal_smooth_muscle1.07474071
75MP0004043_abnormal_pH_regulation1.07128240
76MP0002925_abnormal_cardiovascular_devel1.05344569
77MP0001188_hyperpigmentation1.04603136
78MP0002233_abnormal_nose_morphology1.03980168
79MP0001502_abnormal_circadian_rhythm1.01865159
80MP0000462_abnormal_digestive_system1.00618603
81MP0000750_abnormal_muscle_regeneration1.00519078
82MP0000778_abnormal_nervous_system1.00043778
83MP0004084_abnormal_cardiac_muscle0.97842719
84MP0002115_abnormal_skeleton_extremities0.97658093
85MP0002111_abnormal_tail_morphology0.97639203
86MP0002234_abnormal_pharynx_morphology0.97435636
87MP0005023_abnormal_wound_healing0.97240284
88MP0001286_abnormal_eye_development0.96558413
89MP0002114_abnormal_axial_skeleton0.96267111
90MP0002254_reproductive_system_inflammat0.95826050
91MP0003121_genomic_imprinting0.95705229
92MP0003984_embryonic_growth_retardation0.95540510
93MP0000538_abnormal_urinary_bladder0.94305602
94MP0004134_abnormal_chest_morphology0.94212851
95MP0002088_abnormal_embryonic_growth/wei0.93500098
96MP0000759_abnormal_skeletal_muscle0.93337910
97MP0002877_abnormal_melanocyte_morpholog0.93213722
98MP0001730_embryonic_growth_arrest0.92934380
99MP0001672_abnormal_embryogenesis/_devel0.92300143
100MP0005380_embryogenesis_phenotype0.92300143
101MP0006138_congestive_heart_failure0.91606888
102MP0000566_synostosis0.90178079
103MP0005595_abnormal_vascular_smooth0.89952269
104MP0005248_abnormal_Harderian_gland0.89849217
105MP0004885_abnormal_endolymph0.89329757
106MP0002938_white_spotting0.89287363
107MP0000467_abnormal_esophagus_morphology0.88770261
108MP0001697_abnormal_embryo_size0.88484265
109MP0000516_abnormal_urinary_system0.88234648
110MP0005367_renal/urinary_system_phenotyp0.88234648
111MP0005174_abnormal_tail_pigmentation0.88142192
112MP0002109_abnormal_limb_morphology0.87497629
113MP0001243_abnormal_dermal_layer0.87181837
114MP0000678_abnormal_parathyroid_gland0.86365273
115MP0002086_abnormal_extraembryonic_tissu0.85701594
116MP0002168_other_aberrant_phenotype0.84426589
117MP0002113_abnormal_skeleton_development0.83661321
118MP0003453_abnormal_keratinocyte_physiol0.83406890
119MP0010630_abnormal_cardiac_muscle0.83181954
120MP0001614_abnormal_blood_vessel0.82833481
121MP0009703_decreased_birth_body0.82520387
122MP0004087_abnormal_muscle_fiber0.82018892
123MP0005375_adipose_tissue_phenotype0.82005455
124MP0001879_abnormal_lymphatic_vessel0.81699073
125MP0000266_abnormal_heart_morphology0.81340020
126MP0001986_abnormal_taste_sensitivity0.73959127
127MP0005670_abnormal_white_adipose0.73020715
128MP0000579_abnormal_nail_morphology0.72068278
129MP0005501_abnormal_skin_physiology0.69412922
130MP0000747_muscle_weakness0.67745606
131MP0002933_joint_inflammation0.66328988
132MP0010771_integument_phenotype0.65596738
133MP0005197_abnormal_uvea_morphology0.64762390
134MP0005330_cardiomyopathy0.62823537
135MP0001340_abnormal_eyelid_morphology0.61824031
136MP0005058_abnormal_lysosome_morphology0.60823079
137MP0002796_impaired_skin_barrier0.60746563
138MP0010386_abnormal_urinary_bladder0.60216587

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.39318393
2Premature rupture of membranes (HP:0001788)4.53062880
3Shallow orbits (HP:0000586)4.42210402
4Ankle contracture (HP:0006466)3.72491868
5Broad metatarsal (HP:0001783)3.50061965
6Neonatal short-limb short stature (HP:0008921)3.18892992
7Short 4th metacarpal (HP:0010044)3.17901265
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.17901265
9Vascular tortuosity (HP:0004948)3.10774699
10Bladder diverticulum (HP:0000015)3.09613769
11Joint stiffness (HP:0001387)2.83926359
12Atrophic scars (HP:0001075)2.81937043
13Cerebral aneurysm (HP:0004944)2.76864407
14Increased circulating renin level (HP:0000848)2.76797346
15Rib fusion (HP:0000902)2.68999975
16Arterial tortuosity (HP:0005116)2.67860779
17Thin bony cortex (HP:0002753)2.67018743
18Soft skin (HP:0000977)2.64108251
19Renal duplication (HP:0000075)2.62659227
20Cervical subluxation (HP:0003308)2.61177632
21Wrist flexion contracture (HP:0001239)2.61156108
22Obstructive sleep apnea (HP:0002870)2.58659271
23Abnormality of dentin (HP:0010299)2.56531561
24Hypokalemic alkalosis (HP:0001949)2.51945212
25Bowing of the arm (HP:0006488)2.48190763
26Bowed forearm bones (HP:0003956)2.48190763
27Aortic dissection (HP:0002647)2.48185073
28Spinal rigidity (HP:0003306)2.46684654
29Abnormality of the 4th metacarpal (HP:0010012)2.40521127
30Polyuria (HP:0000103)2.39183268
31Lymphangioma (HP:0100764)2.38573232
32Increased connective tissue (HP:0009025)2.36783636
33Metabolic alkalosis (HP:0200114)2.36467526
34Round ear (HP:0100830)2.35133551
35Hypercalciuria (HP:0002150)2.32336456
36Vertebral compression fractures (HP:0002953)2.31934284
37Testicular atrophy (HP:0000029)2.29089426
38Coronal craniosynostosis (HP:0004440)2.26588852
39Hypoventilation (HP:0002791)2.24134557
40Blue sclerae (HP:0000592)2.23902540
41Aortic regurgitation (HP:0001659)2.20264303
42Hypomagnesemia (HP:0002917)2.19495318
43Bowel diverticulosis (HP:0005222)2.18376732
44Genu recurvatum (HP:0002816)2.18249671
45Fragile skin (HP:0001030)2.17370394
46Abnormal urine output (HP:0012590)2.16646698
47Wormian bones (HP:0002645)2.16618359
48Wide anterior fontanel (HP:0000260)2.14822366
49Aortic aneurysm (HP:0004942)2.13046502
50Disproportionate tall stature (HP:0001519)2.12178409
51Ectopia lentis (HP:0001083)2.11399386
52Hyperactive renin-angiotensin system (HP:0000841)2.10956314
53Mitral valve prolapse (HP:0001634)2.10835725
54Deviation of the hallux (HP:0010051)2.10764486
55Pterygium (HP:0001059)2.06485851
56Dilatation of the ascending aorta (HP:0005111)2.06461541
57Abnormality of chloride homeostasis (HP:0011422)2.06059084
58Type 1 muscle fiber predominance (HP:0003803)2.04153700
59Hepatoblastoma (HP:0002884)2.01736581
60Generalized amyotrophy (HP:0003700)2.00006199
61Aortic valve stenosis (HP:0001650)1.99571963
62Annular pancreas (HP:0001734)1.99112463
63Hallux valgus (HP:0001822)1.98447954
64Broad face (HP:0000283)1.97579568
65Hyperextensible skin (HP:0000974)1.97189878
66Natal tooth (HP:0000695)1.96996962
67Mildly elevated creatine phosphokinase (HP:0008180)1.95733755
68Overgrowth (HP:0001548)1.95577629
69Turricephaly (HP:0000262)1.95475649
70Congenital glaucoma (HP:0001087)1.94317817
71Gout (HP:0001997)1.94072201
72Shawl scrotum (HP:0000049)1.93371836
73Asymmetry of the thorax (HP:0001555)1.93351520
74Selective tooth agenesis (HP:0001592)1.92184879
75Flat cornea (HP:0007720)1.91990446
76Follicular hyperkeratosis (HP:0007502)1.91978019
77Camptodactyly of toe (HP:0001836)1.91862943
78Renal salt wasting (HP:0000127)1.91056130
79Abnormality of renal excretion (HP:0011036)1.90763800
80Slender build (HP:0001533)1.88783719
81Mild short stature (HP:0003502)1.88617538
82Muscle fiber splitting (HP:0003555)1.88441836
83Hip contracture (HP:0003273)1.88056103
84Broad toe (HP:0001837)1.87394007
85Broad long bones (HP:0005622)1.86529744
86Broad thumb (HP:0011304)1.86311100
87Bicornuate uterus (HP:0000813)1.86130742
88Delayed epiphyseal ossification (HP:0002663)1.86016899
89Narrow nasal bridge (HP:0000446)1.84649479
90Elfin facies (HP:0004428)1.84465612
91Infantile muscular hypotonia (HP:0008947)1.83066908
92Joint laxity (HP:0001388)1.82983220
93Knee flexion contracture (HP:0006380)1.82483119
94Morphological abnormality of the middle ear (HP:0008609)1.82387177
95Abnormality of skeletal muscle fiber size (HP:0012084)1.80276582
96Choanal stenosis (HP:0000452)1.79615806
97Metaphyseal cupping (HP:0003021)1.79481216
98Peritonitis (HP:0002586)1.79247484
99Abnormal drinking behavior (HP:0030082)1.77520717
100Polydipsia (HP:0001959)1.77520717
101Mitral regurgitation (HP:0001653)1.77319066
102Ulnar bowing (HP:0003031)1.77315508
103Distal upper limb amyotrophy (HP:0007149)1.77216875
104Upper limb amyotrophy (HP:0009129)1.77216875
105Inguinal hernia (HP:0000023)1.76803122
106Short nail (HP:0001799)1.76067478
107Abnormality of the distal phalanx of the thumb (HP:0009617)1.75905968
108Long toe (HP:0010511)1.75294605
109Ulnar deviation of the wrist (HP:0003049)1.75152902
110Bronchomalacia (HP:0002780)1.75056079
111Tibial bowing (HP:0002982)1.74964501
112Slender long bone (HP:0003100)1.73336400
113Abnormality of magnesium homeostasis (HP:0004921)1.72224776
114Mesomelia (HP:0003027)1.70828777
115Aneurysm (HP:0002617)1.69604573
116Advanced eruption of teeth (HP:0006288)1.69338541
117Aplasia of the musculature (HP:0100854)1.66796951
118Femoral bowing (HP:0002980)1.66270342
119Hypokalemia (HP:0002900)1.66256032
120Abnormal ossification of hand bones (HP:0005921)1.66083107
121Broad phalanx (HP:0006009)1.65704453
122Elbow flexion contracture (HP:0002987)1.65383712
123Long palpebral fissure (HP:0000637)1.65317947
124Broad phalanges of the hand (HP:0009768)1.64993290
125Biconcave vertebral bodies (HP:0004586)1.64760274
126Short hallux (HP:0010109)1.64310345
127Thin ribs (HP:0000883)1.64009404
128Abnormal number of incisors (HP:0011064)1.62521931
129Trigonocephaly (HP:0000243)1.62475367
130Congenital hip dislocation (HP:0001374)1.62352570
131Broad finger (HP:0001500)1.62216148
132Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61929865
133Down-sloping shoulders (HP:0200021)1.61637180
134Buphthalmos (HP:0000557)1.60677940
135Broad hallux (HP:0010055)1.60093271
136Limited hip movement (HP:0008800)1.59444135
137Hyperacusis (HP:0010780)1.59111036
138Hand muscle atrophy (HP:0009130)1.58666204
139Abnormality of the acetabulum (HP:0003170)1.58307231
140Atelectasis (HP:0100750)1.57837750
141Increased variability in muscle fiber diameter (HP:0003557)1.57761820
142Premature skin wrinkling (HP:0100678)1.57759138
143Broad ribs (HP:0000885)1.57224331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.58405905
2DDR23.35876814
3LATS13.15842531
4WNK43.13679290
5CDK123.10584744
6PDGFRA3.02479831
7WNK32.84166501
8TTN2.66916546
9MAPK152.60604441
10EPHB22.46775644
11ICK2.26732167
12LATS22.19433379
13OXSR12.14672009
14STK38L2.08594015
15MST1R2.04047731
16EPHA21.77672366
17PTK21.77126019
18MUSK1.75970536
19MET1.74577974
20PKN21.70828253
21PAK41.69079252
22BMX1.68997366
23SMG11.58828416
24RPS6KA21.51684093
25LRRK21.41300789
26TYRO31.40822628
27MTOR1.39810741
28MAP3K101.38556843
29PAK21.34688500
30PTK61.32496780
31WNK11.31773418
32FGFR11.31496185
33PRPF4B1.27651011
34PRKD31.25646261
35SIK11.24190424
36ERN11.22311806
37PAK31.21622123
38NEK11.20684289
39STK391.20428270
40MAP3K61.20168955
41TGFBR11.16078543
42IRAK31.12346145
43RIPK11.11164622
44STK31.09142110
45DMPK1.05818406
46FER1.04438257
47EEF2K0.95825760
48PDGFRB0.94778200
49CDK70.94634945
50FGFR40.94298625
51BRD40.93331615
52MARK10.91463229
53ILK0.90842880
54PASK0.89078483
55BCR0.88102264
56FGFR20.87788414
57RPS6KC10.87743752
58RPS6KL10.87743752
59ACVR1B0.84286937
60PRKD20.84060448
61CDC42BPA0.77399607
62CAMK1D0.74333076
63LIMK10.73870294
64ROCK20.73804710
65RPS6KA60.73051403
66ROCK10.72983507
67HIPK20.71893730
68MAPKAPK30.71550090
69DYRK1B0.70442488
70PRKG20.68845730
71DAPK30.66942486
72MAP3K70.66667567
73CAMK1G0.64359154
74NTRK10.63983874
75MAP3K90.62518550
76MAPK70.62027213
77ABL20.61320083
78NEK20.60135576
79RPS6KB20.59317469
80AKT20.59223664
81TRPM70.58949111
82TGFBR20.58116413
83IRAK20.57624508
84CSNK1A1L0.57570341
85PRKCI0.55981812
86GSK3A0.55560467
87CDK80.55244081
88CDK60.54296051
89EPHA30.52397371
90ARAF0.52088882
91TIE10.51543011
92ERBB30.51172976
93ADRBK10.51141837
94MKNK10.50696574
95PDPK10.49182090
96TTK0.49110135
97CDK90.48335250
98CAMK2G0.47704704
99AKT30.47254452
100PAK10.46676902
101TAOK20.44042465
102PRKD10.43746954
103STK380.43709370
104LMTK20.43641514
105EPHB10.43538762
106UHMK10.43012246
107PIM20.42452735
108STK100.41949758
109BUB10.41059277
110DYRK30.40943717
111CDK11A0.39981391
112PAK60.39873689
113BRAF0.39839853
114ERBB20.39062554
115PHKG10.39028675
116PHKG20.39028675
117MAP2K20.38825183
118NTRK30.38380048
119CDK140.37743348
120CAMK2B0.37355857
121MAPK10.37084116
122TESK10.36390020
123ERBB40.36265902
124MYLK0.35928301
125STK160.35744615
126CHEK10.35607017
127MAP3K80.35545804
128MAP2K10.35292307
129RET0.35178592
130MAPK80.34903492
131INSR0.34016625
132SIK20.33804865
133CDK150.33736598
134TESK20.33690404
135NEK90.33532751
136AURKB0.33306496
137CDK180.33135284
138SGK4940.32925069
139SGK2230.32925069
140ZAK0.32049057
141PTK2B0.31313435
142MARK20.31052903

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.19402508
2Basal cell carcinoma_Homo sapiens_hsa052173.16608725
3Hedgehog signaling pathway_Homo sapiens_hsa043403.04392876
4Hippo signaling pathway_Homo sapiens_hsa043902.82235286
5Sulfur relay system_Homo sapiens_hsa041222.66320177
6Protein digestion and absorption_Homo sapiens_hsa049742.57288489
7Focal adhesion_Homo sapiens_hsa045102.56124879
8Adherens junction_Homo sapiens_hsa045202.40116972
9Proteoglycans in cancer_Homo sapiens_hsa052052.13087531
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.12447600
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.02172800
12Bladder cancer_Homo sapiens_hsa052191.98676700
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.96046080
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.94777792
15TGF-beta signaling pathway_Homo sapiens_hsa043501.89531704
16Tight junction_Homo sapiens_hsa045301.88423257
17MicroRNAs in cancer_Homo sapiens_hsa052061.86899286
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.84609616
19Small cell lung cancer_Homo sapiens_hsa052221.83087582
20Notch signaling pathway_Homo sapiens_hsa043301.70357323
21Lysine degradation_Homo sapiens_hsa003101.67437967
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63182095
23Dilated cardiomyopathy_Homo sapiens_hsa054141.58905527
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54025486
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49507189
26Wnt signaling pathway_Homo sapiens_hsa043101.42094360
27PI3K-Akt signaling pathway_Homo sapiens_hsa041511.38276793
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38046981
29Melanoma_Homo sapiens_hsa052181.38027042
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32018614
31Pathways in cancer_Homo sapiens_hsa052001.29646890
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.28912616
33Chronic myeloid leukemia_Homo sapiens_hsa052201.28319010
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27844491
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27808685
36Cell cycle_Homo sapiens_hsa041101.26823354
37Prostate cancer_Homo sapiens_hsa052151.24929305
38Axon guidance_Homo sapiens_hsa043601.22033578
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21698649
40Amoebiasis_Homo sapiens_hsa051461.20139880
41Fructose and mannose metabolism_Homo sapiens_hsa000511.19551212
42Endometrial cancer_Homo sapiens_hsa052131.18927454
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15857538
44Cocaine addiction_Homo sapiens_hsa050301.15367926
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08986484
46Renal cell carcinoma_Homo sapiens_hsa052111.08947140
47Colorectal cancer_Homo sapiens_hsa052101.04910787
48Viral myocarditis_Homo sapiens_hsa054161.04820018
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.04701395
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03921302
51p53 signaling pathway_Homo sapiens_hsa041151.02694644
52Butanoate metabolism_Homo sapiens_hsa006500.99313638
53Rap1 signaling pathway_Homo sapiens_hsa040150.99216754
54Glioma_Homo sapiens_hsa052140.97253378
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96640470
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96342338
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94762759
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93631014
59Melanogenesis_Homo sapiens_hsa049160.91216608
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91005119
61mTOR signaling pathway_Homo sapiens_hsa041500.90931621
62Nitrogen metabolism_Homo sapiens_hsa009100.90482747
63VEGF signaling pathway_Homo sapiens_hsa043700.89225665
64Prion diseases_Homo sapiens_hsa050200.89056489
65HTLV-I infection_Homo sapiens_hsa051660.88364544
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.87930584
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87519901
68RNA transport_Homo sapiens_hsa030130.85284129
69Circadian rhythm_Homo sapiens_hsa047100.84243940
70Other glycan degradation_Homo sapiens_hsa005110.79528124
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75973108
72Pancreatic cancer_Homo sapiens_hsa052120.75867511
73GnRH signaling pathway_Homo sapiens_hsa049120.75377492
74Thyroid cancer_Homo sapiens_hsa052160.75151657
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73631790
76Insulin secretion_Homo sapiens_hsa049110.73329811
77MAPK signaling pathway_Homo sapiens_hsa040100.72881589
78Biosynthesis of amino acids_Homo sapiens_hsa012300.72193237
79Gap junction_Homo sapiens_hsa045400.71916890
80mRNA surveillance pathway_Homo sapiens_hsa030150.70096292
81Spliceosome_Homo sapiens_hsa030400.69917450
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69432604
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.69417979
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69051780
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67911952
86Vibrio cholerae infection_Homo sapiens_hsa051100.67715203
87Arginine and proline metabolism_Homo sapiens_hsa003300.66433335
88AMPK signaling pathway_Homo sapiens_hsa041520.66216529
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65991701
90Bile secretion_Homo sapiens_hsa049760.65061121
91Fatty acid metabolism_Homo sapiens_hsa012120.62605914
92Shigellosis_Homo sapiens_hsa051310.62483799
93ErbB signaling pathway_Homo sapiens_hsa040120.62010972
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61882627
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61217063
96Glucagon signaling pathway_Homo sapiens_hsa049220.60577233
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59966648
98Mineral absorption_Homo sapiens_hsa049780.59779519
99Carbon metabolism_Homo sapiens_hsa012000.59490161
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59008964
101Glutathione metabolism_Homo sapiens_hsa004800.58800864
102cAMP signaling pathway_Homo sapiens_hsa040240.58644955
103Vitamin B6 metabolism_Homo sapiens_hsa007500.58456266
104FoxO signaling pathway_Homo sapiens_hsa040680.58353349
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57890282
106Sphingolipid metabolism_Homo sapiens_hsa006000.57230884
107HIF-1 signaling pathway_Homo sapiens_hsa040660.55852607
108Ovarian steroidogenesis_Homo sapiens_hsa049130.54603444
109Oxytocin signaling pathway_Homo sapiens_hsa049210.52418587
110Galactose metabolism_Homo sapiens_hsa000520.52343197
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52200023
112Thyroid hormone synthesis_Homo sapiens_hsa049180.52122589
113Inositol phosphate metabolism_Homo sapiens_hsa005620.52042572
114Non-small cell lung cancer_Homo sapiens_hsa052230.49973737
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48274334
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.48181690
117Dorso-ventral axis formation_Homo sapiens_hsa043200.48052435
118Cholinergic synapse_Homo sapiens_hsa047250.48004690
119Viral carcinogenesis_Homo sapiens_hsa052030.47774346
120Calcium signaling pathway_Homo sapiens_hsa040200.47575968
121Gastric acid secretion_Homo sapiens_hsa049710.47523509
122Insulin resistance_Homo sapiens_hsa049310.46956559
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44922381
124Propanoate metabolism_Homo sapiens_hsa006400.44260656
125Pyruvate metabolism_Homo sapiens_hsa006200.42248830
126N-Glycan biosynthesis_Homo sapiens_hsa005100.42240367
127Glutamatergic synapse_Homo sapiens_hsa047240.41406160
128Ras signaling pathway_Homo sapiens_hsa040140.41050117
129Choline metabolism in cancer_Homo sapiens_hsa052310.40500489
130Insulin signaling pathway_Homo sapiens_hsa049100.38861862
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.38260752
132Endocytosis_Homo sapiens_hsa041440.36581110
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35769365
134Estrogen signaling pathway_Homo sapiens_hsa049150.35596752
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35301508

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