GLIS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to vitamin D (GO:0071305)4.74359678
2type B pancreatic cell development (GO:0003323)4.67922549
3regulation of apoptotic process involved in morphogenesis (GO:1902337)4.33449105
4glandular epithelial cell development (GO:0002068)4.33186080
5regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.96558431
6omega-hydroxylase P450 pathway (GO:0097267)3.93807791
7cellular response to vitamin (GO:0071295)3.84970793
8mesenchymal-epithelial cell signaling (GO:0060638)3.66619030
9negative regulation of keratinocyte proliferation (GO:0010839)3.65622852
10nephron tubule formation (GO:0072079)3.63391770
11skin morphogenesis (GO:0043589)3.61431003
12negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.59699980
13regulation of male gonad development (GO:2000018)3.56936312
14regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.53973136
15gland morphogenesis (GO:0022612)3.48930366
16negative regulation of hormone biosynthetic process (GO:0032353)3.41660158
17negative regulation of hormone metabolic process (GO:0032351)3.41660158
18regulation of keratinocyte proliferation (GO:0010837)3.40351348
19positive regulation of hormone biosynthetic process (GO:0046886)3.39345903
20metanephric tubule development (GO:0072170)3.35712137
21metanephric nephron tubule development (GO:0072234)3.35712137
22columnar/cuboidal epithelial cell development (GO:0002066)3.35499627
23negative regulation of osteoblast proliferation (GO:0033689)3.33627938
24positive regulation of hormone metabolic process (GO:0032352)3.29444024
25regulation of mesenchymal cell apoptotic process (GO:2001053)3.26649733
26mesenchymal cell differentiation involved in renal system development (GO:2001012)3.25706502
27mesenchymal cell differentiation involved in kidney development (GO:0072161)3.25706502
28metanephric nephron epithelium development (GO:0072243)3.25350185
29metanephric epithelium development (GO:0072207)3.25016992
30metanephric mesenchyme development (GO:0072075)3.24527295
31mesonephros development (GO:0001823)3.22632324
32sequestering of extracellular ligand from receptor (GO:0035581)3.21352730
33glomerular basement membrane development (GO:0032836)3.18487962
34lateral sprouting from an epithelium (GO:0060601)3.17887770
35radial glial cell differentiation (GO:0060019)3.17250213
36cilium movement (GO:0003341)3.16193068
37regulation of non-canonical Wnt signaling pathway (GO:2000050)3.14134602
38Golgi transport vesicle coating (GO:0048200)3.07096024
39COPI coating of Golgi vesicle (GO:0048205)3.07096024
40axonemal dynein complex assembly (GO:0070286)3.06545467
41mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.05938452
42cell adhesion mediated by integrin (GO:0033627)3.05683628
43exocrine pancreas development (GO:0031017)3.05292491
44regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.04329627
45endocrine pancreas development (GO:0031018)3.02609133
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02570994
47negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.00758654
48bone trabecula formation (GO:0060346)3.00048138
49cell differentiation involved in metanephros development (GO:0072202)2.99299899
50collagen fibril organization (GO:0030199)2.98666747
51positive regulation of meiosis (GO:0045836)2.97755200
52lung vasculature development (GO:0060426)2.96394416
53kidney mesenchyme development (GO:0072074)2.93923795
54regulation of type B pancreatic cell apoptotic process (GO:2000674)2.91946564
55negative regulation of metanephros development (GO:0072217)2.91896822
56cilium or flagellum-dependent cell motility (GO:0001539)2.91087038
57regulation of steroid hormone biosynthetic process (GO:0090030)2.89864044
58neuron projection extension involved in neuron projection guidance (GO:1902284)2.89714042
59axon extension involved in axon guidance (GO:0048846)2.89714042
60pattern specification involved in kidney development (GO:0061004)2.88550123
61urogenital system development (GO:0001655)2.87792293
62camera-type eye morphogenesis (GO:0048593)2.86454969
63epithelial cilium movement (GO:0003351)2.84296463
64cranial nerve morphogenesis (GO:0021602)2.82872113
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.82150048
66glandular epithelial cell differentiation (GO:0002067)2.81570840
67chondrocyte proliferation (GO:0035988)2.81037766
68regulation of axon extension involved in axon guidance (GO:0048841)2.80905975
69nephron epithelium development (GO:0072009)2.79506914
70regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.79492791
71embryonic retina morphogenesis in camera-type eye (GO:0060059)2.79287140
72nephron tubule development (GO:0072080)2.79115004
73regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.76294427
74positive regulation of meiotic cell cycle (GO:0051446)2.75359267
75activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.72920644
76aminoglycoside antibiotic metabolic process (GO:0030647)2.69047192
77negative regulation of axon extension involved in axon guidance (GO:0048843)2.68033737
78apical protein localization (GO:0045176)2.67842062
79mesenchymal cell differentiation (GO:0048762)2.64943138
80left/right pattern formation (GO:0060972)2.64869878
81negative chemotaxis (GO:0050919)2.64826405
82regulation of axon guidance (GO:1902667)2.63803368
83regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.60848299
84regulation of osteoblast proliferation (GO:0033688)2.60796402
85regulation of glucocorticoid metabolic process (GO:0031943)2.58188647
86interkinetic nuclear migration (GO:0022027)2.57962062
87regulation of hormone biosynthetic process (GO:0046885)2.57185180
88regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.56440584
89mammary gland epithelial cell differentiation (GO:0060644)2.55561344
90anatomical structure arrangement (GO:0048532)2.55013143
91response to vitamin D (GO:0033280)2.54828344
92oocyte development (GO:0048599)2.53614059
93negative regulation of chondrocyte differentiation (GO:0032331)2.53478241
94renal tubule development (GO:0061326)2.52621716
95endodermal cell differentiation (GO:0035987)2.49118649
96female gonad development (GO:0008585)2.49060098
97protein retention in ER lumen (GO:0006621)2.48291346
98facial nerve structural organization (GO:0021612)2.47254164
99collagen catabolic process (GO:0030574)2.46465084
100positive regulation of p38MAPK cascade (GO:1900745)2.45877588
101branch elongation of an epithelium (GO:0060602)2.45678762
102collagen metabolic process (GO:0032963)2.45170128
103kidney morphogenesis (GO:0060993)2.45035106
104protein heterotrimerization (GO:0070208)2.45015150
105chondrocyte development (GO:0002063)2.44245669
106negative regulation of axon guidance (GO:1902668)2.43942843
107astrocyte differentiation (GO:0048708)2.43359091
108mesenchymal to epithelial transition (GO:0060231)2.42844939
109regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41886224
110mesodermal cell differentiation (GO:0048333)2.39062320
111branching involved in salivary gland morphogenesis (GO:0060445)2.38786558
112regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.37529196
113cartilage morphogenesis (GO:0060536)2.36905500
114embryonic camera-type eye morphogenesis (GO:0048596)2.36361128
115regulation of hormone metabolic process (GO:0032350)2.36079343
116cell migration involved in sprouting angiogenesis (GO:0002042)2.35696825
117platelet-derived growth factor receptor signaling pathway (GO:0048008)2.35665942
118macroautophagy (GO:0016236)2.35004660
119regulation of female gonad development (GO:2000194)2.34575923
120ganglion development (GO:0061548)2.34572027
121regulation of mesonephros development (GO:0061217)2.34275838
122sequestering of metal ion (GO:0051238)2.33575224
123planar cell polarity pathway involved in neural tube closure (GO:0090179)2.33054717
124extracellular regulation of signal transduction (GO:1900115)2.31977510
125extracellular negative regulation of signal transduction (GO:1900116)2.31977510
126substrate-dependent cell migration (GO:0006929)2.31166829
127positive regulation of bone mineralization (GO:0030501)2.30751157
128multicellular organismal macromolecule metabolic process (GO:0044259)2.30743213
129pancreas development (GO:0031016)2.30320614
130pericardium development (GO:0060039)2.29377627
131positive regulation of male gonad development (GO:2000020)2.29319725
132positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.29130947
133asymmetric protein localization (GO:0008105)2.28985483
134axis elongation (GO:0003401)2.28679853
135multicellular organismal catabolic process (GO:0044243)2.28393256
136regulation of metanephros development (GO:0072215)2.28297066
137endocrine hormone secretion (GO:0060986)2.28249550
138establishment of tissue polarity (GO:0007164)2.27734387
139establishment of planar polarity (GO:0001736)2.27734387
140multicellular organismal metabolic process (GO:0044236)2.27538832
141endothelial cell chemotaxis (GO:0035767)2.27276213
142regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.27033356
143regulation of integrin-mediated signaling pathway (GO:2001044)2.27029136
144positive regulation of steroid biosynthetic process (GO:0010893)2.26834415
145embryonic epithelial tube formation (GO:0001838)2.26684670
146dermatan sulfate biosynthetic process (GO:0030208)2.26618743
147vascular endothelial growth factor signaling pathway (GO:0038084)2.26419316
148positive regulation of protein autophosphorylation (GO:0031954)2.25774619
149positive regulation of astrocyte differentiation (GO:0048711)2.22807668
150paraxial mesoderm development (GO:0048339)2.19857551
151interleukin-6-mediated signaling pathway (GO:0070102)2.19694949
152smooth muscle tissue development (GO:0048745)2.18107215
153lens fiber cell development (GO:0070307)2.14980534
154limb development (GO:0060173)2.14725462
155appendage development (GO:0048736)2.14725462
156Notch signaling involved in heart development (GO:0061314)2.13776479
157face morphogenesis (GO:0060325)2.13032275
158negative regulation of vascular permeability (GO:0043116)2.10218970
159positive regulation of extracellular matrix organization (GO:1903055)2.08200399
160venous blood vessel morphogenesis (GO:0048845)2.08055197
161extracellular matrix assembly (GO:0085029)2.07804293
162negative regulation of protein localization to cell surface (GO:2000009)2.07260893
163neuronal stem cell maintenance (GO:0097150)2.06739794
164extracellular matrix disassembly (GO:0022617)2.06357834
165regulation of extracellular matrix disassembly (GO:0010715)2.05095091
166COPII vesicle coating (GO:0048208)2.03847182
167wound healing (GO:0042060)2.03773188
168auditory receptor cell differentiation (GO:0042491)2.02590348
169regulation of membrane protein ectodomain proteolysis (GO:0051043)2.01549285
170negative regulation of gluconeogenesis (GO:0045721)1.98804024
171positive regulation of cell junction assembly (GO:1901890)1.98691525
172positive regulation of focal adhesion assembly (GO:0051894)1.98691525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.91590960
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.89147191
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.76867664
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.61051238
5GBX2_23144817_ChIP-Seq_PC3_Human2.42140434
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13167716
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11727480
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09729242
9* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.04886637
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.03918881
11IGF1R_20145208_ChIP-Seq_DFB_Human2.02767873
12PIAS1_25552417_ChIP-Seq_VCAP_Human1.98594260
13ESR1_21235772_ChIP-Seq_MCF-7_Human1.96224611
14TP53_16413492_ChIP-PET_HCT116_Human1.90404066
15* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.86271085
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83657385
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.79650037
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78172163
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.76577807
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75696538
21* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73828771
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.70658321
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68058112
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68041993
25* CJUN_26792858_Chip-Seq_BT549_Human1.67031789
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66903069
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66519727
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61230347
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59508118
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58682662
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55132286
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.52812670
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.47320793
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.46309175
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46211138
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46159462
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45920251
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.45527710
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.43708941
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42973592
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.42874001
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42792879
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41638847
44TP53_18474530_ChIP-ChIP_U2OS_Human1.39992620
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38147976
46* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38107966
47* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38107966
48* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38105697
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37146714
50* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36918307
51* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36918307
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36217618
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35742458
54RNF2_27304074_Chip-Seq_NSC_Mouse1.33385214
55* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33124064
56* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32386701
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.31558673
58P300_19829295_ChIP-Seq_ESCs_Human1.31516523
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31013828
60* BRD4_25478319_ChIP-Seq_HGPS_Human1.30739107
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.30611108
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30609626
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28559259
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28058441
65* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28049262
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26275850
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24202167
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23677134
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23355705
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23213569
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23059064
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23059064
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23059064
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22564176
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21912606
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21678131
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21359573
78* STAT3_23295773_ChIP-Seq_U87_Human1.21306623
79* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20940533
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.20692745
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20672376
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19388186
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.19284385
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.19119760
85* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18590896
86AR_21572438_ChIP-Seq_LNCaP_Human1.18584121
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17858767
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.17331098
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.16334271
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15193812
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14355744
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13108386
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12781793
94* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12311052
95P53_22387025_ChIP-Seq_ESCs_Mouse1.12192125
96* TP63_23658742_ChIP-Seq_EP156T_Human1.11393367
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10951716
98ESR1_20079471_ChIP-ChIP_T-47D_Human1.10818640
99LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10765355
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.10263062
101* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10120712
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09700655
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09599894
104SOX2_20726797_ChIP-Seq_SW620_Human1.08963101
105FOXO3_23340844_ChIP-Seq_DLD1_Human1.08681693
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07985704
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07780740
108NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07639240
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07520647
110NMYC_18555785_Chip-Seq_ESCs_Mouse1.07106061
111* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05767612
112AR_25329375_ChIP-Seq_VCAP_Human1.05492693
113* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04763618
114RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04420439
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04085048
116SMAD4_21741376_ChIP-Seq_HESCs_Human1.03675587
117* RUNX2_22187159_ChIP-Seq_PCA_Human1.03487863
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02344436
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.02083706
120AHR_22903824_ChIP-Seq_MCF-7_Human1.01521128
121RXR_22108803_ChIP-Seq_LS180_Human1.00974775
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00387841
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.00141865
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.98590751
125* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98546877
126BCAT_22108803_ChIP-Seq_LS180_Human0.98498916
127CMYC_18555785_Chip-Seq_ESCs_Mouse0.98466834
128ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98452709
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97739051
130ISL1_27105846_Chip-Seq_CPCs_Mouse0.97332588
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.93238471
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92911182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.24480253
2MP0005257_abnormal_intraocular_pressure3.05425972
3MP0000566_synostosis2.96801838
4MP0005503_abnormal_tendon_morphology2.88682787
5MP0008438_abnormal_cutaneous_collagen2.86054949
6MP0003283_abnormal_digestive_organ2.76975534
7MP0006292_abnormal_olfactory_placode2.49131695
8MP0002928_abnormal_bile_duct2.39858717
9MP0000678_abnormal_parathyroid_gland2.31980928
10MP0009250_abnormal_appendicular_skeleto2.26432751
11MP0009384_cardiac_valve_regurgitation2.07574307
12MP0002138_abnormal_hepatobiliary_system2.00675760
13MP0001879_abnormal_lymphatic_vessel1.99011922
14MP0002896_abnormal_bone_mineralization1.98199132
15MP0001346_abnormal_lacrimal_gland1.97931182
16MP0002177_abnormal_outer_ear1.95326205
17MP0001299_abnormal_eye_distance/1.95131241
18MP0005508_abnormal_skeleton_morphology1.94555505
19* MP0001944_abnormal_pancreas_morphology1.90863657
20MP0001958_emphysema1.90777356
21MP0005220_abnormal_exocrine_pancreas1.90416657
22MP0005023_abnormal_wound_healing1.85190143
23MP0003279_aneurysm1.80566259
24MP0009780_abnormal_chondrocyte_physiolo1.80517815
25MP0001188_hyperpigmentation1.78620108
26MP0004043_abnormal_pH_regulation1.77940982
27MP0000163_abnormal_cartilage_morphology1.73647371
28MP0010352_gastrointestinal_tract_polyps1.68168863
29MP0005275_abnormal_skin_tensile1.67684272
30MP0002909_abnormal_adrenal_gland1.65833082
31MP0003183_abnormal_peptide_metabolism1.65773393
32MP0003136_yellow_coat_color1.64670248
33MP0003937_abnormal_limbs/digits/tail_de1.64136445
34MP0010030_abnormal_orbit_morphology1.60976039
35MP0002938_white_spotting1.60879209
36MP0005084_abnormal_gallbladder_morpholo1.60337562
37MP0004272_abnormal_basement_membrane1.59314474
38MP0000613_abnormal_salivary_gland1.59028165
39MP0003300_gastrointestinal_ulcer1.56298741
40MP0000428_abnormal_craniofacial_morphol1.55799818
41MP0000049_abnormal_middle_ear1.55465419
42MP0003942_abnormal_urinary_system1.54852976
43MP0003195_calcinosis1.51435970
44MP0010386_abnormal_urinary_bladder1.49964124
45MP0002115_abnormal_skeleton_extremities1.49566606
46MP0001756_abnormal_urination1.47796867
47MP0002168_other_aberrant_phenotype1.45632017
48MP0005248_abnormal_Harderian_gland1.44887710
49* MP0002693_abnormal_pancreas_physiology1.42715572
50MP0000462_abnormal_digestive_system1.42007170
51MP0002249_abnormal_larynx_morphology1.40539819
52MP0003950_abnormal_plasma_membrane1.40528941
53MP0003705_abnormal_hypodermis_morpholog1.40386407
54MP0002116_abnormal_craniofacial_bone1.40375665
55MP0003045_fibrosis1.40058635
56MP0005595_abnormal_vascular_smooth1.39913633
57MP0001984_abnormal_olfaction1.38026808
58MP0000013_abnormal_adipose_tissue1.33871319
59MP0003755_abnormal_palate_morphology1.31494539
60MP0001542_abnormal_bone_strength1.30199188
61MP0005171_absent_coat_pigmentation1.29187049
62MP0002113_abnormal_skeleton_development1.27819873
63MP0000432_abnormal_head_morphology1.27792094
64MP0002109_abnormal_limb_morphology1.27438084
65MP0005379_endocrine/exocrine_gland_phen1.26970471
66MP0000767_abnormal_smooth_muscle1.26563996
67MP0004134_abnormal_chest_morphology1.25796754
68MP0003385_abnormal_body_wall1.25021442
69MP0004885_abnormal_endolymph1.24770313
70MP0003935_abnormal_craniofacial_develop1.23955685
71MP0000778_abnormal_nervous_system1.22980225
72MP0002295_abnormal_pulmonary_circulatio1.22290001
73MP0002233_abnormal_nose_morphology1.18637721
74MP0009840_abnormal_foam_cell1.18441514
75MP0000762_abnormal_tongue_morphology1.17115360
76MP0000631_abnormal_neuroendocrine_gland1.16536912
77MP0001502_abnormal_circadian_rhythm1.16045312
78MP0002933_joint_inflammation1.13483554
79MP0003943_abnormal_hepatobiliary_system1.13346122
80MP0003941_abnormal_skin_development1.13182931
81MP0002932_abnormal_joint_morphology1.12515784
82MP0005390_skeleton_phenotype1.12104360
83MP0000681_abnormal_thyroid_gland1.10471670
84MP0000534_abnormal_ureter_morphology1.08343441
85MP0004859_abnormal_synaptic_plasticity1.06907930
86MP0005623_abnormal_meninges_morphology1.04703586
87MP0002108_abnormal_muscle_morphology1.04446308
88MP0005164_abnormal_response_to1.03915657
89MP0002998_abnormal_bone_remodeling1.03628671
90MP0001765_abnormal_ion_homeostasis1.01851297
91MP0002282_abnormal_trachea_morphology1.00500462
92MP0000569_abnormal_digit_pigmentation0.99999990
93MP0003795_abnormal_bone_structure0.99876723
94MP0004510_myositis0.96019667
95MP0010678_abnormal_skin_adnexa0.95266923
96MP0003936_abnormal_reproductive_system0.94887642
97MP0005377_hearing/vestibular/ear_phenot0.94348727
98MP0003878_abnormal_ear_physiology0.94348727
99MP0000516_abnormal_urinary_system0.94268589
100MP0005367_renal/urinary_system_phenotyp0.94268589
101MP0002009_preneoplasia0.93487831
102MP0001270_distended_abdomen0.91783467
103MP0005409_darkened_coat_color0.90848631
104MP0000579_abnormal_nail_morphology0.90530927
105MP0001293_anophthalmia0.89742710
106MP0005646_abnormal_pituitary_gland0.89282516
107MP0008007_abnormal_cellular_replicative0.89254921
108MP0005197_abnormal_uvea_morphology0.89236058
109MP0000383_abnormal_hair_follicle0.88758472
110MP0000003_abnormal_adipose_tissue0.88605491
111MP0000026_abnormal_inner_ear0.88516591
112MP0001186_pigmentation_phenotype0.88415935
113MP0003566_abnormal_cell_adhesion0.86758491
114MP0003868_abnormal_feces_composition0.86570142
115MP0003724_increased_susceptibility_to0.86318188
116MP0008004_abnormal_stomach_pH0.85645341
117MP0002098_abnormal_vibrissa_morphology0.84942681
118MP0000733_abnormal_muscle_development0.84659702
119MP0006054_spinal_hemorrhage0.84520783
120MP0002060_abnormal_skin_morphology0.83985743
121MP0010368_abnormal_lymphatic_system0.83384556
122MP0005408_hypopigmentation0.82890709
123MP0002653_abnormal_ependyma_morphology0.81795983
124MP0003634_abnormal_glial_cell0.80936620
125MP0005395_other_phenotype0.80413993
126MP0001119_abnormal_female_reproductive0.79536055
127MP0002234_abnormal_pharynx_morphology0.78394245
128MP0003252_abnormal_bile_duct0.76997417
129MP0009053_abnormal_anal_canal0.76563760
130MP0003091_abnormal_cell_migration0.75933530
131MP0000538_abnormal_urinary_bladder0.75584015
132MP0001986_abnormal_taste_sensitivity0.75438021
133MP0002092_abnormal_eye_morphology0.74900057
134MP0002114_abnormal_axial_skeleton0.74260848
135MP0004858_abnormal_nervous_system0.67914074
136MP0001501_abnormal_sleep_pattern0.67904253
137MP0003122_maternal_imprinting0.67724542
138MP0004133_heterotaxia0.66717689
139MP0005193_abnormal_anterior_eye0.66385075

Predicted human phenotypes

RankGene SetZ-score
1Vascular tortuosity (HP:0004948)4.02975768
2Arterial tortuosity (HP:0005116)3.88020753
3Mitral stenosis (HP:0001718)3.22440148
4Protrusio acetabuli (HP:0003179)3.11882249
5Premature rupture of membranes (HP:0001788)3.09862531
6Cervical subluxation (HP:0003308)3.05253255
7Abnormal ciliary motility (HP:0012262)3.00437067
8Unilateral renal agenesis (HP:0000122)2.98062937
9Absent frontal sinuses (HP:0002688)2.91601215
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.91571666
11Abnormal respiratory motile cilium physiology (HP:0012261)2.81100258
12Rhinitis (HP:0012384)2.70667399
13Ulnar bowing (HP:0003031)2.68972718
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.60940017
15Abnormal respiratory epithelium morphology (HP:0012253)2.59543943
16Abnormal respiratory motile cilium morphology (HP:0005938)2.59543943
17Abnormality of calcium-phosphate metabolism (HP:0100530)2.55665466
18Osteomalacia (HP:0002749)2.54060863
19Hyperactive renin-angiotensin system (HP:0000841)2.53732309
20Nuclear cataract (HP:0100018)2.50605865
21Flat capital femoral epiphysis (HP:0003370)2.49766893
22Abnormality of chloride homeostasis (HP:0011422)2.49172071
23Coronal craniosynostosis (HP:0004440)2.48139999
24Bladder diverticulum (HP:0000015)2.47242784
25Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.46345279
26Aortic regurgitation (HP:0001659)2.43866485
27Midline defect of the nose (HP:0004122)2.43620135
28Soft skin (HP:0000977)2.41963066
29Hyperextensible skin (HP:0000974)2.40619408
30Neonatal short-limb short stature (HP:0008921)2.39390019
31Insulin-resistant diabetes mellitus (HP:0000831)2.36371551
32Hypomagnesemia (HP:0002917)2.34890082
33Increased circulating renin level (HP:0000848)2.33457204
34Delayed gross motor development (HP:0002194)2.32678251
35Ankle contracture (HP:0006466)2.32432018
36Atrophic scars (HP:0001075)2.31396829
37Broad face (HP:0000283)2.28152731
38Follicular hyperkeratosis (HP:0007502)2.27818854
39Abnormality of incisor morphology (HP:0011063)2.27207804
40Aortic dissection (HP:0002647)2.27057328
41Vertebral arch anomaly (HP:0008438)2.25723100
42Shallow orbits (HP:0000586)2.23072395
43Abnormal pancreas size (HP:0012094)2.20899620
44Hyperinsulinemic hypoglycemia (HP:0000825)2.20574427
45Agitation (HP:0000713)2.19939135
46Nonprogressive disorder (HP:0003680)2.19702535
47Genu recurvatum (HP:0002816)2.18207167
48Abnormality of the parietal bone (HP:0002696)2.18102807
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.17336904
50Absent/shortened dynein arms (HP:0200106)2.17336904
51Turricephaly (HP:0000262)2.16758238
52Mitral valve prolapse (HP:0001634)2.15727028
53Abnormality of magnesium homeostasis (HP:0004921)2.10936320
54Wide anterior fontanel (HP:0000260)2.08923856
55Type I transferrin isoform profile (HP:0003642)2.08821597
56Overgrowth (HP:0001548)2.07913036
57Thoracolumbar scoliosis (HP:0002944)2.07722472
58Hypoplasia of the iris (HP:0007676)2.04577559
59Abnormality of dentin (HP:0010299)2.04055339
60Abnormality of renin-angiotensin system (HP:0000847)2.03275271
61Mesomelia (HP:0003027)2.01231712
62Peritonitis (HP:0002586)2.00701496
63Metabolic alkalosis (HP:0200114)1.98996407
64Symptomatic seizures (HP:0011145)1.98207774
65Epiphyseal dysplasia (HP:0002656)1.97282694
66Bell-shaped thorax (HP:0001591)1.97142291
67Short nail (HP:0001799)1.96918590
68Mitral regurgitation (HP:0001653)1.96730961
69Spinal cord compression (HP:0002176)1.95871092
70Hypokalemia (HP:0002900)1.95815203
71Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.95202579
72Cystic liver disease (HP:0006706)1.94800362
73Fibular hypoplasia (HP:0003038)1.94006701
74Occipital encephalocele (HP:0002085)1.92111819
75Limited hip movement (HP:0008800)1.91864103
76Bowed forearm bones (HP:0003956)1.89029275
77Bowing of the arm (HP:0006488)1.89029275
78Atelectasis (HP:0100750)1.86116222
79Buphthalmos (HP:0000557)1.86061324
80Exocrine pancreatic insufficiency (HP:0001738)1.86043104
81Abnormality of the frontal sinuses (HP:0002687)1.86024453
82Shawl scrotum (HP:0000049)1.85573468
83Femoral bowing (HP:0002980)1.84520914
84Bowel diverticulosis (HP:0005222)1.84455291
85Metaphyseal irregularity (HP:0003025)1.84121928
86Tetany (HP:0001281)1.81586341
87Hypoplastic ischia (HP:0003175)1.80169472
88Thin bony cortex (HP:0002753)1.79890585
89Venous insufficiency (HP:0005293)1.79583836
90Abnormality of the renal medulla (HP:0100957)1.79581860
91Aplasia/hypoplasia of the uterus (HP:0008684)1.79104140
92Abnormality of the nasal septum (HP:0000419)1.78380239
93Stage 5 chronic kidney disease (HP:0003774)1.77909926
94Bronchomalacia (HP:0002780)1.77798643
95Mild short stature (HP:0003502)1.77691655
96Striae distensae (HP:0001065)1.77495897
97Spondylolisthesis (HP:0003302)1.77357898
98Hypoglycemic seizures (HP:0002173)1.76259682
99Abnormality of the phalanges of the hallux (HP:0010057)1.76195135
100Decreased skull ossification (HP:0004331)1.73780977
101Hemiparesis (HP:0001269)1.73703317
102Cubitus valgus (HP:0002967)1.73548446
103Obstructive sleep apnea (HP:0002870)1.73426646
104Keratoconus (HP:0000563)1.73405174
105Increased corneal curvature (HP:0100692)1.73405174
106Lip pit (HP:0100267)1.73136441
107Aortic valve stenosis (HP:0001650)1.73011830
108Abnormality of potassium homeostasis (HP:0011042)1.72805974
109Hypoplasia of the odontoid process (HP:0003311)1.72597792
110Tibial bowing (HP:0002982)1.72219565
111Aortic aneurysm (HP:0004942)1.71523874
112Glucose intolerance (HP:0000833)1.71295907
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70758267
114Abnormal protein N-linked glycosylation (HP:0012347)1.70758267
115Abnormal protein glycosylation (HP:0012346)1.70758267
116Abnormal glycosylation (HP:0012345)1.70758267
117Disproportionate short-trunk short stature (HP:0003521)1.69633167
118Hyperphosphatemia (HP:0002905)1.69588774
119Broad metatarsal (HP:0001783)1.69360575
120Irregular vertebral endplates (HP:0003301)1.68939143
121Hypokalemic alkalosis (HP:0001949)1.68672888
122Osteoarthritis (HP:0002758)1.68582512
123Knee flexion contracture (HP:0006380)1.67306853
124Abnormality of the phalanges of the 2nd finger (HP:0009541)1.67068338
125Arthropathy (HP:0003040)1.66125586
126Blue sclerae (HP:0000592)1.65415511
127Decreased circulating renin level (HP:0003351)1.65212891
128Congenital sensorineural hearing impairment (HP:0008527)1.64391382
129Spinal rigidity (HP:0003306)1.64172583
130Fragile skin (HP:0001030)1.63731047
131Exostoses (HP:0100777)1.63068117
132Polyuria (HP:0000103)1.62839284
133Pancreatic fibrosis (HP:0100732)1.62689838
134Cardiovascular calcification (HP:0011915)1.62190977
135Nasolacrimal duct obstruction (HP:0000579)1.60650761
136Joint laxity (HP:0001388)1.60125861
137Abnormality of polysaccharide metabolism (HP:0011012)1.59766382
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.59766382
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.59766382
140Polydipsia (HP:0001959)1.59246616
141Abnormal drinking behavior (HP:0030082)1.59246616
142Broad long bones (HP:0005622)1.59148348
143Delayed epiphyseal ossification (HP:0002663)1.59132963
144Abnormality of the ischium (HP:0003174)1.59003842
145Wormian bones (HP:0002645)1.58747626
146Aplasia involving bones of the upper limbs (HP:0009823)1.58522114
147Aplasia of the phalanges of the hand (HP:0009802)1.58522114
148Aplasia involving bones of the extremities (HP:0009825)1.58522114
149Craniofacial hyperostosis (HP:0004493)1.57677540
150Aplasia/Hypoplasia of the fovea (HP:0008060)1.57606265
151Hypoplasia of the fovea (HP:0007750)1.57606265
152Abnormality of the odontoid process (HP:0003310)1.57564117
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.57408415
154Osteolytic defects of the hand bones (HP:0009699)1.57408415
155Pulmonic stenosis (HP:0001642)1.57275344
156True hermaphroditism (HP:0010459)1.56908011
157Increased number of teeth (HP:0011069)1.56857064
158Potter facies (HP:0002009)1.55034626
159Facial shape deformation (HP:0011334)1.55034626
160Mucopolysacchariduria (HP:0008155)1.54877147
161Urinary glycosaminoglycan excretion (HP:0003541)1.54877147
162Infantile muscular hypotonia (HP:0008947)1.54395296
163Deviation of the hallux (HP:0010051)1.52541752
164Vertebral compression fractures (HP:0002953)1.52245896
165Aplasia/Hypoplasia of the fibula (HP:0006492)1.50070178
166Hypoventilation (HP:0002791)1.49267763
167Metaphyseal dysplasia (HP:0100255)1.49087925
168Biconcave vertebral bodies (HP:0004586)1.48415692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.85295620
2INSRR3.84811574
3LMTK23.45979691
4TAOK32.99309078
5MUSK2.98277493
6MKNK22.80200047
7TNIK2.70345389
8MAPK152.58850421
9STK242.51878072
10NTRK12.34931393
11NLK2.34649977
12PRKD22.30269079
13DDR22.23030457
14WNK42.05575455
15IRAK32.00010187
16FGFR21.92761103
17MYLK1.92264354
18FER1.92100012
19WNK31.90738289
20HIPK21.88175177
21PASK1.88006797
22CDK121.84161127
23PNCK1.68647138
24FRK1.68538262
25NEK91.68473008
26RIPK11.68461317
27MKNK11.54223130
28PDGFRA1.52021907
29CASK1.51078907
30STK38L1.47858684
31EPHA21.46165531
32IRAK11.43093279
33NUAK11.41374801
34CAMK1G1.39723368
35PINK11.35689126
36EIF2AK31.32400718
37EPHA31.28808979
38CDK81.28623565
39MST41.27162234
40STK31.23520589
41CDC42BPA1.16630375
42MAP3K91.14332404
43PTK21.10952086
44TEC1.10630734
45ROCK21.08262497
46SIK11.07375890
47ZAK1.06903675
48MAP3K61.06327985
49BRSK21.05984597
50ROCK11.05288185
51AKT31.04568793
52PDGFRB1.01681843
53NTRK31.01364421
54SIK30.97618945
55PAK60.97380789
56BMPR1B0.95235196
57LIMK10.94860095
58CHUK0.90031905
59TTN0.89985308
60DMPK0.87117323
61STK390.86464884
62MARK10.86037600
63PRKD30.85763424
64MARK20.83502876
65PIK3CA0.83086631
66MAP3K20.82742786
67CDK90.82517819
68IRAK40.82394901
69FGFR30.82059438
70MAPK130.81324472
71MAP3K30.80897851
72PTK2B0.80138476
73PAK30.77851536
74TRPM70.77766148
75PLK20.77375379
76EPHB20.75846995
77MAP2K70.75576004
78NEK60.75329574
79JAK30.74694757
80BCR0.74620433
81CDK70.74530865
82TESK10.73704712
83TGFBR20.73315482
84PRKG20.71803200
85CAMKK20.71256388
86NTRK20.67963887
87GRK10.67286396
88CAMK2G0.64836578
89WNK10.64025695
90FLT30.63853428
91SGK20.63171356
92SGK2230.62640479
93SGK4940.62640479
94MET0.61049640
95FES0.61026900
96MAP3K70.60717790
97EIF2AK20.60677405
98LATS20.60390372
99SGK30.60083103
100MELK0.59823589
101ERBB40.59078998
102PRKCE0.58941747
103CAMK1D0.58474522
104MST1R0.57981855
105FGFR10.57949584
106IRAK20.57058675
107CSNK1G10.56927469
108OXSR10.54965045
109STK380.54266832
110SRPK10.54029267
111PRKCI0.53714021
112MAP3K10.53161064
113EPHB10.52303118
114MAP3K40.51116674
115PRKCG0.50821246
116PLK40.49843152
117NME20.49442343
118ERN10.49386243
119MAPKAPK50.48278085
120CDK30.47929174
121ADRBK10.47718601
122ABL10.46460454
123CSNK1A1L0.45955994
124CSNK1G20.45771464
125MAP3K120.45330937
126MAP3K140.44998716
127MOS0.43887233
128ADRBK20.43651050
129CAMK2A0.43413623
130PHKG20.38898535
131PHKG10.38898535
132DYRK1B0.38779668
133PAK20.38059760
134PRKAA20.37393735
135INSR0.37270418
136MTOR0.36926168
137ABL20.36681939
138JAK10.36264990
139CDK50.35290842
140CHEK20.34743506
141CAMK2B0.34335440
142BMPR20.33706081
143BMX0.32565331
144ERBB30.32534056
145GSK3A0.32158446
146ACVR1B0.32104440
147IKBKB0.31708331
148CAMK2D0.30142540

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.28997180
2Protein export_Homo sapiens_hsa030602.97587101
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.10436545
4ECM-receptor interaction_Homo sapiens_hsa045122.10106674
5Protein digestion and absorption_Homo sapiens_hsa049741.81603507
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64213141
7Other glycan degradation_Homo sapiens_hsa005111.59558539
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.56524246
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50688538
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50617290
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48917470
12N-Glycan biosynthesis_Homo sapiens_hsa005101.45122285
13Focal adhesion_Homo sapiens_hsa045101.40419294
14Basal cell carcinoma_Homo sapiens_hsa052171.39332977
15Prostate cancer_Homo sapiens_hsa052151.36020872
16Sphingolipid metabolism_Homo sapiens_hsa006001.33503026
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32603552
18Adherens junction_Homo sapiens_hsa045201.31253154
19Ovarian steroidogenesis_Homo sapiens_hsa049131.28644932
20Circadian rhythm_Homo sapiens_hsa047101.28470767
21Insulin secretion_Homo sapiens_hsa049111.27099979
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25825144
23Complement and coagulation cascades_Homo sapiens_hsa046101.24982415
24Tight junction_Homo sapiens_hsa045301.23325641
25MicroRNAs in cancer_Homo sapiens_hsa052061.23134733
26Sulfur metabolism_Homo sapiens_hsa009201.22716145
27TGF-beta signaling pathway_Homo sapiens_hsa043501.18120181
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17559446
29Wnt signaling pathway_Homo sapiens_hsa043101.17483151
30p53 signaling pathway_Homo sapiens_hsa041151.16021505
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15121616
32Dilated cardiomyopathy_Homo sapiens_hsa054141.13942054
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13406535
34Hedgehog signaling pathway_Homo sapiens_hsa043401.13038149
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07556197
36Melanoma_Homo sapiens_hsa052181.07343852
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06026959
38Thyroid cancer_Homo sapiens_hsa052161.05114582
39Axon guidance_Homo sapiens_hsa043601.01525980
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00631337
41Hippo signaling pathway_Homo sapiens_hsa043901.00242630
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99479942
43Prolactin signaling pathway_Homo sapiens_hsa049170.99314937
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99233671
45Small cell lung cancer_Homo sapiens_hsa052220.98362942
46Mineral absorption_Homo sapiens_hsa049780.96242966
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95895086
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.95130216
49Arachidonic acid metabolism_Homo sapiens_hsa005900.95053041
50Bladder cancer_Homo sapiens_hsa052190.94990424
51Vitamin B6 metabolism_Homo sapiens_hsa007500.94655130
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93847806
53Type II diabetes mellitus_Homo sapiens_hsa049300.93579647
54Fanconi anemia pathway_Homo sapiens_hsa034600.92810423
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91604402
56Malaria_Homo sapiens_hsa051440.90977329
57Prion diseases_Homo sapiens_hsa050200.87946985
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.87200089
59TNF signaling pathway_Homo sapiens_hsa046680.87054182
60Basal transcription factors_Homo sapiens_hsa030220.85437543
61beta-Alanine metabolism_Homo sapiens_hsa004100.84845374
62Bile secretion_Homo sapiens_hsa049760.84469216
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84203660
64Proteoglycans in cancer_Homo sapiens_hsa052050.80847757
65Pancreatic cancer_Homo sapiens_hsa052120.80316028
66Pathways in cancer_Homo sapiens_hsa052000.79181959
67Type I diabetes mellitus_Homo sapiens_hsa049400.77534665
68Renal cell carcinoma_Homo sapiens_hsa052110.77429395
69Lysosome_Homo sapiens_hsa041420.76127362
70Renin secretion_Homo sapiens_hsa049240.76017610
71Pancreatic secretion_Homo sapiens_hsa049720.76008907
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75085710
73Gap junction_Homo sapiens_hsa045400.74633058
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72941242
75Amoebiasis_Homo sapiens_hsa051460.72683188
76Amphetamine addiction_Homo sapiens_hsa050310.71724884
77Dorso-ventral axis formation_Homo sapiens_hsa043200.70860983
78Ras signaling pathway_Homo sapiens_hsa040140.70525055
79ABC transporters_Homo sapiens_hsa020100.67405197
80Cell cycle_Homo sapiens_hsa041100.66788074
81Butanoate metabolism_Homo sapiens_hsa006500.66512968
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65397490
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65352278
84FoxO signaling pathway_Homo sapiens_hsa040680.65038719
85Chronic myeloid leukemia_Homo sapiens_hsa052200.64097182
86Notch signaling pathway_Homo sapiens_hsa043300.63275694
87cAMP signaling pathway_Homo sapiens_hsa040240.63271448
88Histidine metabolism_Homo sapiens_hsa003400.62571051
89Endometrial cancer_Homo sapiens_hsa052130.62364016
90Choline metabolism in cancer_Homo sapiens_hsa052310.61981918
91Cocaine addiction_Homo sapiens_hsa050300.61451284
92Taste transduction_Homo sapiens_hsa047420.61043435
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60169219
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.59915420
95Salivary secretion_Homo sapiens_hsa049700.59426571
96Glutamatergic synapse_Homo sapiens_hsa047240.59304860
97RNA degradation_Homo sapiens_hsa030180.59295955
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59090850
99Circadian entrainment_Homo sapiens_hsa047130.58782775
100Thyroid hormone synthesis_Homo sapiens_hsa049180.58104900
101Hepatitis B_Homo sapiens_hsa051610.58084580
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58073179
103Hematopoietic cell lineage_Homo sapiens_hsa046400.57834098
104HTLV-I infection_Homo sapiens_hsa051660.57670764
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57485676
106Colorectal cancer_Homo sapiens_hsa052100.57036756
107Dopaminergic synapse_Homo sapiens_hsa047280.56203044
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56183959
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.55096472
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54689507
111Toxoplasmosis_Homo sapiens_hsa051450.53994738
112Measles_Homo sapiens_hsa051620.53945512
113Vibrio cholerae infection_Homo sapiens_hsa051100.53767235
114Nitrogen metabolism_Homo sapiens_hsa009100.53648107
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53314419
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53195865
117Rap1 signaling pathway_Homo sapiens_hsa040150.53054247
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51814995
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51327505
120Galactose metabolism_Homo sapiens_hsa000520.51032586
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.50491834
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49842559
123mTOR signaling pathway_Homo sapiens_hsa041500.49439988
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49360124
125Herpes simplex infection_Homo sapiens_hsa051680.49246693
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48068137
127Melanogenesis_Homo sapiens_hsa049160.48017188
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.48015057
129Lysine degradation_Homo sapiens_hsa003100.47966265
130Salmonella infection_Homo sapiens_hsa051320.47255161
131Serotonergic synapse_Homo sapiens_hsa047260.47067462
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46457177
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46386369
134Rheumatoid arthritis_Homo sapiens_hsa053230.46179652
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45913987
136Homologous recombination_Homo sapiens_hsa034400.45875183
137Linoleic acid metabolism_Homo sapiens_hsa005910.45712835
138Pertussis_Homo sapiens_hsa051330.45643948
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45038438
140Collecting duct acid secretion_Homo sapiens_hsa049660.44080103
141Acute myeloid leukemia_Homo sapiens_hsa052210.43771063
142Chemical carcinogenesis_Homo sapiens_hsa052040.42907822
143Gastric acid secretion_Homo sapiens_hsa049710.42765720

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