GLMN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)5.97471987
2rhodopsin mediated signaling pathway (GO:0016056)5.68973087
3GMP metabolic process (GO:0046037)5.21915321
4piRNA metabolic process (GO:0034587)4.57979397
5retinal cone cell development (GO:0046549)4.56972195
6DNA double-strand break processing (GO:0000729)4.55179389
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.13589109
8regulation of mitotic spindle checkpoint (GO:1903504)4.13589109
9cullin deneddylation (GO:0010388)3.99013635
10DNA methylation involved in gamete generation (GO:0043046)3.91455873
11protein deneddylation (GO:0000338)3.86323673
12maturation of 5.8S rRNA (GO:0000460)3.81738736
13negative regulation of DNA-dependent DNA replication (GO:2000104)3.80412270
14somatic diversification of immune receptors via somatic mutation (GO:0002566)3.77897847
15somatic hypermutation of immunoglobulin genes (GO:0016446)3.77897847
16photoreceptor cell development (GO:0042461)3.75999775
17DNA replication-dependent nucleosome organization (GO:0034723)3.65902657
18DNA replication-dependent nucleosome assembly (GO:0006335)3.65902657
19eye photoreceptor cell development (GO:0042462)3.64946667
20kinetochore organization (GO:0051383)3.58504939
21photoreceptor cell maintenance (GO:0045494)3.58238581
22replication fork processing (GO:0031297)3.56782199
23histone mRNA metabolic process (GO:0008334)3.50737102
24DNA ligation (GO:0006266)3.49887646
25regulation of helicase activity (GO:0051095)3.48308169
26CENP-A containing nucleosome assembly (GO:0034080)3.46427999
27protein neddylation (GO:0045116)3.45763353
28IMP biosynthetic process (GO:0006188)3.45671668
297-methylguanosine mRNA capping (GO:0006370)3.44718758
30histone H2A acetylation (GO:0043968)3.44327268
31DNA damage response, detection of DNA damage (GO:0042769)3.44235024
327-methylguanosine RNA capping (GO:0009452)3.42263044
33RNA capping (GO:0036260)3.42263044
34DNA catabolic process, exonucleolytic (GO:0000738)3.39708936
35viral mRNA export from host cell nucleus (GO:0046784)3.39298349
36ribosome assembly (GO:0042255)3.37518448
37proteasome assembly (GO:0043248)3.36027313
38chromatin remodeling at centromere (GO:0031055)3.35669506
39attachment of spindle microtubules to kinetochore (GO:0008608)3.35091908
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32983909
41synapsis (GO:0007129)3.25947511
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23931383
43chaperone-mediated protein transport (GO:0072321)3.23819180
44somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.23581564
45somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.23581564
46isotype switching (GO:0045190)3.23581564
47establishment of integrated proviral latency (GO:0075713)3.23093129
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21457537
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21220797
50transcription-coupled nucleotide-excision repair (GO:0006283)3.19583781
51mitotic metaphase plate congression (GO:0007080)3.18920453
52non-recombinational repair (GO:0000726)3.18643262
53double-strand break repair via nonhomologous end joining (GO:0006303)3.18643262
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18316184
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18316184
56kinetochore assembly (GO:0051382)3.18019436
57telomere maintenance via semi-conservative replication (GO:0032201)3.17852798
58negative regulation of DNA recombination (GO:0045910)3.17822047
59base-excision repair, AP site formation (GO:0006285)3.17341709
60DNA strand elongation involved in DNA replication (GO:0006271)3.17299402
61telomere maintenance via recombination (GO:0000722)3.17016697
62DNA replication checkpoint (GO:0000076)3.15949524
63resolution of meiotic recombination intermediates (GO:0000712)3.15054340
64mitochondrial RNA metabolic process (GO:0000959)3.14050484
65histone exchange (GO:0043486)3.13463644
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.13062333
67mitotic recombination (GO:0006312)3.10161134
68pseudouridine synthesis (GO:0001522)3.09757082
69nuclear pore organization (GO:0006999)3.09381308
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.08536067
71nucleotide-excision repair, DNA gap filling (GO:0006297)3.07462083
72transcription from mitochondrial promoter (GO:0006390)3.07007566
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05909425
74negative regulation of ligase activity (GO:0051352)3.05909425
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05818288
76purine nucleobase biosynthetic process (GO:0009113)3.04250937
77IMP metabolic process (GO:0046040)3.03600635
78DNA strand elongation (GO:0022616)3.01680576
79metaphase plate congression (GO:0051310)2.97579277
80microtubule depolymerization (GO:0007019)2.97483447
81detection of light stimulus involved in visual perception (GO:0050908)2.97330312
82detection of light stimulus involved in sensory perception (GO:0050962)2.97330312
83postreplication repair (GO:0006301)2.94318684
84DNA replication-independent nucleosome assembly (GO:0006336)2.94023977
85DNA replication-independent nucleosome organization (GO:0034724)2.94023977
86transcription elongation from RNA polymerase I promoter (GO:0006362)2.92090653
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91219428
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91219428
89regulation of chromosome segregation (GO:0051983)2.90384033
90nucleobase biosynthetic process (GO:0046112)2.90259026
91protein localization to chromosome, centromeric region (GO:0071459)2.90070685
92rRNA methylation (GO:0031167)2.89882821
93regulation of DNA endoreduplication (GO:0032875)2.88982821
94meiotic chromosome segregation (GO:0045132)2.88797415
95spliceosomal complex assembly (GO:0000245)2.88587217
96DNA replication initiation (GO:0006270)2.88469225
97establishment of viral latency (GO:0019043)2.87856256
98spliceosomal snRNP assembly (GO:0000387)2.87106736
99spindle checkpoint (GO:0031577)2.86167497
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84871781
101negative regulation of sister chromatid segregation (GO:0033046)2.84871781
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.84871781
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84871781
104regulation of nuclear cell cycle DNA replication (GO:0033262)2.84196426
105transcription elongation from RNA polymerase II promoter (GO:0006368)2.82991770
106regulation of double-strand break repair via homologous recombination (GO:0010569)2.82476403
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82262480
108negative regulation of mitosis (GO:0045839)2.81191863
109rRNA modification (GO:0000154)2.81147102
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80971435
111mitotic spindle assembly checkpoint (GO:0007094)2.80420234
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80308526
113termination of RNA polymerase I transcription (GO:0006363)2.80076359
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79149506
115regulation of centriole replication (GO:0046599)2.79075034
116mitotic spindle checkpoint (GO:0071174)2.78750484
117spindle assembly checkpoint (GO:0071173)2.78529982
118negative regulation of chromosome segregation (GO:0051985)2.78348044
119pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77912354
120protein K6-linked ubiquitination (GO:0085020)2.77904176
121male meiosis (GO:0007140)2.77674265
122transcription elongation from RNA polymerase III promoter (GO:0006385)2.76822708
123termination of RNA polymerase III transcription (GO:0006386)2.76822708
124mitochondrial respiratory chain complex I assembly (GO:0032981)2.76623465
125NADH dehydrogenase complex assembly (GO:0010257)2.76623465
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76623465
127DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74950157
128regulation of cellular amino acid metabolic process (GO:0006521)2.71921813
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.71157151
130ribosome biogenesis (GO:0042254)2.70952868
131intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70609496
132signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70609496
133cellular response to light stimulus (GO:0071482)2.70324316
134mismatch repair (GO:0006298)2.69482220
135signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.68695956
136signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.68695956
137signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.68695956
138protein localization to kinetochore (GO:0034501)2.66528098
139guanosine-containing compound biosynthetic process (GO:1901070)2.65467837
140transcription initiation from RNA polymerase I promoter (GO:0006361)2.64152402
141regulation of mitotic sister chromatid separation (GO:0010965)2.64132637
142regulation of mitotic sister chromatid segregation (GO:0033047)2.64132637
143regulation of sister chromatid segregation (GO:0033045)2.64132637
144telomere maintenance via telomere lengthening (GO:0010833)2.63576990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.10780546
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85169888
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.56220277
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.23790113
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.11280091
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06892397
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.06065028
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00711395
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98345500
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68329884
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65317752
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.56982273
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55464169
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54715469
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49760455
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.41852572
17YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20902812
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15793266
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14924499
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14739519
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08384026
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06896210
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04568332
24ELK1_19687146_ChIP-ChIP_HELA_Human2.02122035
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01318909
26FUS_26573619_Chip-Seq_HEK293_Human1.99773668
27VDR_23849224_ChIP-Seq_CD4+_Human1.97415366
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93139636
29ZNF274_21170338_ChIP-Seq_K562_Hela1.86416990
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84665533
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80938764
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.79271652
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77167261
34FOXP3_21729870_ChIP-Seq_TREG_Human1.75203235
35VDR_22108803_ChIP-Seq_LS180_Human1.74902063
36DCP1A_22483619_ChIP-Seq_HELA_Human1.72949205
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72697335
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.67804855
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.67014233
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64362131
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63258794
42* EWS_26573619_Chip-Seq_HEK293_Human1.62707298
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61631309
44GABP_19822575_ChIP-Seq_HepG2_Human1.61341758
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60398175
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57696081
47XRN2_22483619_ChIP-Seq_HELA_Human1.56263018
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55657897
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55595075
50AR_21909140_ChIP-Seq_LNCAP_Human1.54343249
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.51333594
52IGF1R_20145208_ChIP-Seq_DFB_Human1.48722962
53TAF15_26573619_Chip-Seq_HEK293_Human1.45030005
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44653274
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43892461
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42213838
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.40751457
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39502272
59TTF2_22483619_ChIP-Seq_HELA_Human1.38941821
60MYC_18940864_ChIP-ChIP_HL60_Human1.38313229
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38070321
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.37655491
63* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36275238
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33083853
65GBX2_23144817_ChIP-Seq_PC3_Human1.30552186
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.27886586
67RNF2_27304074_Chip-Seq_NSC_Mouse1.24933013
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.24634579
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21372893
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18064975
71CIITA_25753668_ChIP-Seq_RAJI_Human1.16817467
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14471861
73CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13453936
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.13202700
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11345723
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11107940
77IRF1_19129219_ChIP-ChIP_H3396_Human1.08859576
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08350868
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05768135
80* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05493852
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01941883
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99236417
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94744357
84NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94480107
85SOX9_26525672_Chip-Seq_HEART_Mouse0.94258184
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94063816
87P300_19829295_ChIP-Seq_ESCs_Human0.93563840
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91768889
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89300918
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.89224173
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88879439
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87953628
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87111588
94REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85645536
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.84986836
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84286985
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83905828
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83123984
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82749188
100ER_23166858_ChIP-Seq_MCF-7_Human0.82416867
101CBX2_27304074_Chip-Seq_ESCs_Mouse0.81995746
102EZH2_22144423_ChIP-Seq_EOC_Human0.81615151
103KDM5A_27292631_Chip-Seq_BREAST_Human0.81264128
104ELK1_22589737_ChIP-Seq_MCF10A_Human0.80490454
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79473916
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78833540
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.78831935
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78829477
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78292481
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78092133
111TP53_22573176_ChIP-Seq_HFKS_Human0.77329727
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77143989
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76825545
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74595486
115PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73890069
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73142954
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.72823862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.17304985
2MP0005551_abnormal_eye_electrophysiolog4.07412740
3MP0006072_abnormal_retinal_apoptosis3.44292643
4MP0008058_abnormal_DNA_repair3.14586760
5MP0010094_abnormal_chromosome_stability3.04950534
6MP0005253_abnormal_eye_physiology3.03987085
7MP0003011_delayed_dark_adaptation2.98059571
8MP0001529_abnormal_vocalization2.72128677
9MP0008057_abnormal_DNA_replication2.70065144
10MP0003693_abnormal_embryo_hatching2.62838597
11MP0002638_abnormal_pupillary_reflex2.49290417
12MP0004957_abnormal_blastocyst_morpholog2.43777595
13MP0001986_abnormal_taste_sensitivity2.39945339
14MP0003880_abnormal_central_pattern2.39763683
15MP0003123_paternal_imprinting2.38316884
16MP0003121_genomic_imprinting2.33394800
17MP0003077_abnormal_cell_cycle2.21161315
18MP0003950_abnormal_plasma_membrane2.11681904
19MP0003111_abnormal_nucleus_morphology2.04562592
20MP0003787_abnormal_imprinting1.96185285
21MP0006292_abnormal_olfactory_placode1.94927489
22MP0001293_anophthalmia1.94925510
23MP0008932_abnormal_embryonic_tissue1.91675939
24MP0009697_abnormal_copulation1.89007749
25MP0001188_hyperpigmentation1.87559921
26MP0003941_abnormal_skin_development1.86188544
27MP0001905_abnormal_dopamine_level1.79117848
28MP0005423_abnormal_somatic_nervous1.74398799
29MP0002210_abnormal_sex_determination1.69551283
30MP0005195_abnormal_posterior_eye1.69386013
31MP0003122_maternal_imprinting1.64814248
32MP0003718_maternal_effect1.57945465
33MP0001929_abnormal_gametogenesis1.55337059
34MP0008007_abnormal_cellular_replicative1.55103274
35MP0005391_vision/eye_phenotype1.53742482
36MP0005499_abnormal_olfactory_system1.52694555
37MP0005394_taste/olfaction_phenotype1.52694555
38MP0003890_abnormal_embryonic-extraembry1.45609880
39MP0002653_abnormal_ependyma_morphology1.39902843
40MP0003786_premature_aging1.39552074
41MP0000653_abnormal_sex_gland1.34438139
42MP0003119_abnormal_digestive_system1.33651370
43MP0001145_abnormal_male_reproductive1.33405490
44MP0001177_atelectasis1.33138212
45MP0002752_abnormal_somatic_nervous1.32116245
46MP0002233_abnormal_nose_morphology1.31597018
47MP0003698_abnormal_male_reproductive1.31526919
48MP0003315_abnormal_perineum_morphology1.29006693
49MP0003806_abnormal_nucleotide_metabolis1.26362797
50MP0006276_abnormal_autonomic_nervous1.24912870
51MP0002102_abnormal_ear_morphology1.23835157
52MP0009672_abnormal_birth_weight1.19287061
53MP0006036_abnormal_mitochondrial_physio1.19193585
54MP0004133_heterotaxia1.16875732
55MP0002736_abnormal_nociception_after1.15856169
56MP0002084_abnormal_developmental_patter1.14496279
57MP0003186_abnormal_redox_activity1.13823500
58MP0001730_embryonic_growth_arrest1.10538274
59MP0001324_abnormal_eye_pigmentation1.10396624
60MP0008995_early_reproductive_senescence1.09769271
61MP0000566_synostosis1.09287062
62MP0002234_abnormal_pharynx_morphology1.08955798
63MP0004270_analgesia1.08673756
64MP0001968_abnormal_touch/_nociception1.07640700
65MP0000350_abnormal_cell_proliferation1.07333927
66MP0002734_abnormal_mechanical_nocicepti1.06634870
67MP0000372_irregular_coat_pigmentation1.05640682
68MP0002272_abnormal_nervous_system1.03468717
69MP0001119_abnormal_female_reproductive1.02978992
70MP0009703_decreased_birth_body1.02751065
71MP0002229_neurodegeneration1.01334492
72MP0001764_abnormal_homeostasis1.00432368
73MP0004197_abnormal_fetal_growth/weight/0.99289894
74MP0004215_abnormal_myocardial_fiber0.98249051
75MP0000778_abnormal_nervous_system0.96805152
76MP0002882_abnormal_neuron_morphology0.96515175
77MP0002127_abnormal_cardiovascular_syste0.95695671
78MP0002080_prenatal_lethality0.92871892
79MP0009745_abnormal_behavioral_response0.92637879
80MP0002160_abnormal_reproductive_system0.92382930
81MP0002161_abnormal_fertility/fecundity0.91894174
82MP0002751_abnormal_autonomic_nervous0.91858620
83MP0003984_embryonic_growth_retardation0.91691511
84MP0000647_abnormal_sebaceous_gland0.91018527
85MP0002572_abnormal_emotion/affect_behav0.90459265
86MP0006035_abnormal_mitochondrial_morpho0.90446611
87MP0001984_abnormal_olfaction0.90346126
88MP0002088_abnormal_embryonic_growth/wei0.89661899
89MP0002697_abnormal_eye_size0.89110012
90MP0000358_abnormal_cell_content/0.88696233
91MP0000313_abnormal_cell_death0.88472635
92MP0009046_muscle_twitch0.87899994
93MP0010386_abnormal_urinary_bladder0.87565320
94MP0003221_abnormal_cardiomyocyte_apopto0.84990775
95MP0003567_abnormal_fetal_cardiomyocyte0.84835324
96MP0002111_abnormal_tail_morphology0.84675724
97MP0003635_abnormal_synaptic_transmissio0.84550844
98MP0002184_abnormal_innervation0.84332673
99MP0003937_abnormal_limbs/digits/tail_de0.82935950
100MP0002938_white_spotting0.82779001
101MP0002254_reproductive_system_inflammat0.82267942
102MP0005386_behavior/neurological_phenoty0.81383206
103MP0004924_abnormal_behavior0.81383206
104MP0003861_abnormal_nervous_system0.81281517
105MP0005410_abnormal_fertilization0.80512733
106MP0008789_abnormal_olfactory_epithelium0.80162653
107MP0001963_abnormal_hearing_physiology0.79885893
108MP0001286_abnormal_eye_development0.79641937
109MP0002067_abnormal_sensory_capabilities0.79351521
110MP0000026_abnormal_inner_ear0.79024927
111MP0000631_abnormal_neuroendocrine_gland0.78706559
112MP0004142_abnormal_muscle_tone0.77946655
113MP0005171_absent_coat_pigmentation0.77789265
114MP0003755_abnormal_palate_morphology0.77729024
115MP0002064_seizures0.77621648
116MP0003938_abnormal_ear_development0.76895819
117MP0002063_abnormal_learning/memory/cond0.76752322
118MP0001697_abnormal_embryo_size0.76675489
119MP0005389_reproductive_system_phenotype0.75719996
120MP0002085_abnormal_embryonic_tissue0.75460675
121MP0003136_yellow_coat_color0.75113461
122MP0005646_abnormal_pituitary_gland0.74094729
123MP0010307_abnormal_tumor_latency0.73233510
124MP0006054_spinal_hemorrhage0.73057018
125MP0001672_abnormal_embryogenesis/_devel0.73036549
126MP0005380_embryogenesis_phenotype0.73036549
127MP0005084_abnormal_gallbladder_morpholo0.72644676
128MP0001485_abnormal_pinna_reflex0.72316650
129MP0002090_abnormal_vision0.71196341
130MP0005075_abnormal_melanosome_morpholog0.70881006
131MP0008872_abnormal_physiological_respon0.70120773
132MP0002163_abnormal_gland_morphology0.69955288
133MP0005187_abnormal_penis_morphology0.69824566
134MP0000049_abnormal_middle_ear0.67915399
135MP0004859_abnormal_synaptic_plasticity0.67009734
136MP0004147_increased_porphyrin_level0.66145349
137MP0000015_abnormal_ear_pigmentation0.65334740
138MP0010030_abnormal_orbit_morphology0.65250960
139MP0003137_abnormal_impulse_conducting0.64949116
140MP0003195_calcinosis0.62724915
141MP0002277_abnormal_respiratory_mucosa0.61908749

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.76464737
2Bony spicule pigmentary retinopathy (HP:0007737)5.30500955
3Abnormal rod and cone electroretinograms (HP:0008323)4.76127928
4Chorioretinal atrophy (HP:0000533)4.38196644
5Absent rod-and cone-mediated responses on ERG (HP:0007688)4.33530798
6Pendular nystagmus (HP:0012043)4.17888957
7Attenuation of retinal blood vessels (HP:0007843)3.92198028
8Birth length less than 3rd percentile (HP:0003561)3.74965580
9Abnormality of the labia minora (HP:0012880)3.55230831
10Increased serum pyruvate (HP:0003542)3.37934387
11Abnormality of glycolysis (HP:0004366)3.37934387
12Medial flaring of the eyebrow (HP:0010747)3.37176117
13Gait imbalance (HP:0002141)3.34129487
14Congenital primary aphakia (HP:0007707)3.31386390
15Nephrogenic diabetes insipidus (HP:0009806)3.22998155
16Pigmentary retinal degeneration (HP:0001146)3.19574974
17Volvulus (HP:0002580)2.94008332
18Lipid accumulation in hepatocytes (HP:0006561)2.88212028
19Poor coordination (HP:0002370)2.85563109
20Acute necrotizing encephalopathy (HP:0006965)2.83249049
21Abnormal hair whorl (HP:0010721)2.82553435
22Pancreatic fibrosis (HP:0100732)2.78295714
23Supernumerary spleens (HP:0009799)2.76886348
24True hermaphroditism (HP:0010459)2.73427870
25Abnormality of macular pigmentation (HP:0008002)2.69974783
26Hyperglycinemia (HP:0002154)2.68377530
27Breast hypoplasia (HP:0003187)2.63983929
28Type II diabetes mellitus (HP:0005978)2.62790405
29Duodenal stenosis (HP:0100867)2.62142010
30Small intestinal stenosis (HP:0012848)2.62142010
31Abnormal mitochondria in muscle tissue (HP:0008316)2.60135063
32Patellar aplasia (HP:0006443)2.58149179
33Optic disc pallor (HP:0000543)2.56980237
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54198446
35Abnormality of alanine metabolism (HP:0010916)2.54198446
36Hyperalaninemia (HP:0003348)2.54198446
37Retinitis pigmentosa (HP:0000510)2.53298684
38Chromsome breakage (HP:0040012)2.52586293
39Genital tract atresia (HP:0001827)2.51406941
40Abnormality of serum amino acid levels (HP:0003112)2.50264737
41Vaginal atresia (HP:0000148)2.50166624
42Photophobia (HP:0000613)2.50075311
43Methylmalonic acidemia (HP:0002912)2.43388199
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43033579
45Central scotoma (HP:0000603)2.40487309
46Cerebral edema (HP:0002181)2.39984841
47Decreased central vision (HP:0007663)2.39429270
48Aplasia/Hypoplasia of the patella (HP:0006498)2.38615296
49Scotoma (HP:0000575)2.38181896
50Pancreatic cysts (HP:0001737)2.36660545
51Abolished electroretinogram (ERG) (HP:0000550)2.35055463
52Progressive macrocephaly (HP:0004481)2.34627831
53Abnormality of the duodenum (HP:0002246)2.33879226
54Dyschromatopsia (HP:0007641)2.32074593
55Triphalangeal thumb (HP:0001199)2.25905564
56Increased corneal curvature (HP:0100692)2.23884770
57Keratoconus (HP:0000563)2.23884770
58Mitochondrial inheritance (HP:0001427)2.23822669
59Reticulocytopenia (HP:0001896)2.20725569
60Abnormality of methionine metabolism (HP:0010901)2.20572797
61Colon cancer (HP:0003003)2.19578206
62Hepatic necrosis (HP:0002605)2.18498391
63Severe visual impairment (HP:0001141)2.17942347
64Nephroblastoma (Wilms tumor) (HP:0002667)2.16956565
65Increased CSF lactate (HP:0002490)2.14144600
66Abnormality of midbrain morphology (HP:0002418)2.13830801
67Molar tooth sign on MRI (HP:0002419)2.13830801
68Rhabdomyosarcoma (HP:0002859)2.07832396
69Abnormality of glycine metabolism (HP:0010895)2.06865300
70Abnormality of serine family amino acid metabolism (HP:0010894)2.06865300
71Embryonal renal neoplasm (HP:0011794)2.06238939
72Renal Fanconi syndrome (HP:0001994)2.06167702
73Ependymoma (HP:0002888)2.05892486
74Abnormality of the anterior horn cell (HP:0006802)2.05595008
75Degeneration of anterior horn cells (HP:0002398)2.05595008
76Horseshoe kidney (HP:0000085)2.04645177
77Cortical dysplasia (HP:0002539)2.03635366
78Medulloblastoma (HP:0002885)2.03552800
79Shoulder girdle muscle weakness (HP:0003547)2.02677301
80Ectopic kidney (HP:0000086)2.02029056
81Abnormal spermatogenesis (HP:0008669)2.01348930
82Hyperglycinuria (HP:0003108)2.01136988
83Cerebral hypomyelination (HP:0006808)2.00648990
84Broad foot (HP:0001769)1.99961882
85Clubbing of toes (HP:0100760)1.98886093
86Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97108486
87Acute encephalopathy (HP:0006846)1.96741094
88Septo-optic dysplasia (HP:0100842)1.96712829
89Abnormal lung lobation (HP:0002101)1.96572240
90Myelodysplasia (HP:0002863)1.94358163
91Gonadotropin excess (HP:0000837)1.92421278
92Lactic acidosis (HP:0003128)1.91046819
93Impulsivity (HP:0100710)1.90974726
94Meckel diverticulum (HP:0002245)1.90952989
95Papillary thyroid carcinoma (HP:0002895)1.90327296
96Epileptic encephalopathy (HP:0200134)1.90171615
97Methylmalonic aciduria (HP:0012120)1.90122457
98Multiple enchondromatosis (HP:0005701)1.89992484
99Preaxial hand polydactyly (HP:0001177)1.89772427
100Type 2 muscle fiber atrophy (HP:0003554)1.89736203
101Aplasia/Hypoplasia of the tibia (HP:0005772)1.87479230
102Increased hepatocellular lipid droplets (HP:0006565)1.86011255
103Hepatocellular necrosis (HP:0001404)1.85821914
104Stenosis of the external auditory canal (HP:0000402)1.85806306
105Abnormality of the carotid arteries (HP:0005344)1.85507957
106Median cleft lip (HP:0000161)1.84659659
107Abnormality of the ileum (HP:0001549)1.84437616
108Neoplasm of the colon (HP:0100273)1.81486867
109Atonic seizures (HP:0010819)1.81094976
110Glioma (HP:0009733)1.80853656
111Nephronophthisis (HP:0000090)1.80143522
112Leukodystrophy (HP:0002415)1.79393593
113Respiratory difficulties (HP:0002880)1.77242821
114Type I transferrin isoform profile (HP:0003642)1.77072680
115Abnormality of the preputium (HP:0100587)1.76924054
116Aplasia/Hypoplasia of the lens (HP:0008063)1.76833262
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.76173963
118Postnatal microcephaly (HP:0005484)1.74832789
119Pancreatic islet-cell hyperplasia (HP:0004510)1.74685515
120Bifid tongue (HP:0010297)1.73844726
121Absent radius (HP:0003974)1.73485218
122Agnosia (HP:0010524)1.73378665
123Progressive inability to walk (HP:0002505)1.72965946
124Absent thumb (HP:0009777)1.72649993
125Astigmatism (HP:0000483)1.71838961
126Short tibia (HP:0005736)1.71721125
127Choroideremia (HP:0001139)1.71410892
128Microvesicular hepatic steatosis (HP:0001414)1.69508073
129Megaloblastic anemia (HP:0001889)1.69499657
130Carpal bone hypoplasia (HP:0001498)1.69197365
131Absent forearm bone (HP:0003953)1.68822764
132Aplasia involving forearm bones (HP:0009822)1.68822764
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68467988
134Aganglionic megacolon (HP:0002251)1.66390847
135Pancytopenia (HP:0001876)1.66208896
136Small hand (HP:0200055)1.65136740
137Absent septum pellucidum (HP:0001331)1.65132609
138Facial cleft (HP:0002006)1.64885905
139Tubulointerstitial nephritis (HP:0001970)1.64239720
140Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.64045121
141Postaxial hand polydactyly (HP:0001162)1.63484019
142Rectal fistula (HP:0100590)1.63461983
143Rectovaginal fistula (HP:0000143)1.63461983
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62314553
145Febrile seizures (HP:0002373)1.62244987
146Increased serum lactate (HP:0002151)1.62090710
147Decreased testicular size (HP:0008734)1.61873595
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.61240536
149Abnormality of chromosome stability (HP:0003220)1.58853454
150Exercise intolerance (HP:0003546)1.58659919
151Sloping forehead (HP:0000340)1.58527666
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.57897065
153Sclerocornea (HP:0000647)1.57695544
154Azoospermia (HP:0000027)1.57230926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.66859129
2PBK3.48133617
3BUB13.12215904
4CCNB12.81995302
5PLK42.80039241
6EIF2AK12.74272538
7CDC72.59145385
8TRIM282.53255017
9WNK32.51668000
10TSSK62.48744296
11SRPK12.46093200
12ACVR1B2.45544558
13MKNK12.32226233
14WEE12.30145675
15MKNK22.29101437
16PLK22.26973027
17VRK22.11861633
18MST42.05633421
19TAF11.89609891
20STK161.85160436
21TTK1.81503419
22PLK31.78786605
23PNCK1.68148056
24NEK11.66707773
25EIF2AK31.65160251
26BMPR1B1.58097410
27AKT31.57058808
28MAP2K71.56558519
29MAP4K21.55295664
30YES11.50921144
31PLK11.48861198
32VRK11.47603846
33BCR1.39394705
34CDK81.33670131
35MAP3K121.33582765
36DYRK21.29482529
37MARK11.28409574
38GRK11.28185918
39CHEK21.21790620
40MAP3K41.18378829
41MAPK131.15469980
42CDK191.11304228
43BRSK21.09154403
44BRAF1.06836935
45SIK31.05867166
46NEK61.05408694
47PDK41.03943432
48PDK31.03943432
49NME11.03145962
50ATR1.00004565
51CSNK1G30.99340896
52FRK0.97412693
53PRPF4B0.94618987
54STK38L0.90757942
55BRSK10.90192917
56AURKA0.89757367
57RPS6KA40.86876464
58ADRBK10.83946204
59CDK30.82461140
60KSR10.81784692
61EPHA40.81299478
62PRKCI0.81188686
63LIMK10.80733637
64MUSK0.80063297
65CSNK1A1L0.78686156
66MYLK0.77463490
67GRK70.77304201
68CHEK10.77181155
69ERBB30.77076871
70AURKB0.76006488
71TGFBR10.74908727
72OXSR10.73468210
73STK390.73339190
74FLT30.72242218
75NEK20.71146052
76MAP3K60.68590321
77TNIK0.68520269
78IRAK20.66603958
79CDK70.65653438
80ZAK0.64872364
81EIF2AK20.64607559
82STK30.63102201
83DYRK1A0.63102018
84CSNK1G20.62905832
85CSNK1G10.62169680
86PASK0.61216696
87BCKDK0.60438832
88ALK0.60378289
89INSRR0.59483469
90ATM0.58126954
91CSNK2A10.56508253
92CDK10.56024893
93PDK20.53087049
94CSNK2A20.51526514
95MARK30.50075042
96MINK10.49178740
97CDK180.48178944
98PRKCG0.47996987
99CDK20.47907224
100DYRK30.47826942
101BMPR20.47803530
102FGFR10.47501944
103PINK10.46492608
104STK40.44631742
105BRD40.42718592
106ERBB40.40741228
107CDK140.38805272
108CAMK2A0.38725161
109MELK0.38435842
110NTRK20.38038566
111CDK150.37286014
112STK240.36695748
113PRKDC0.36023699
114NUAK10.36022071
115CLK10.33829257
116RPS6KA50.33756075
117CSNK1D0.33141499
118WNK40.32871063
119CSNK1E0.32728075
120UHMK10.32262212
121TXK0.31778796
122TIE10.31525637
123CDK11A0.31439328
124ADRBK20.31431740
125CDK60.30198148
126PRKCE0.30013936
127NME20.28765813
128CSNK1A10.26651202
129STK100.26244647
130DAPK10.25335158

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.76590465
2Proteasome_Homo sapiens_hsa030503.72497473
3Mismatch repair_Homo sapiens_hsa034303.68592774
4DNA replication_Homo sapiens_hsa030303.22074322
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17794679
6Basal transcription factors_Homo sapiens_hsa030222.94693815
7RNA polymerase_Homo sapiens_hsa030202.90141682
8Nucleotide excision repair_Homo sapiens_hsa034202.63527968
9Spliceosome_Homo sapiens_hsa030402.61456847
10Base excision repair_Homo sapiens_hsa034102.57995061
11Homologous recombination_Homo sapiens_hsa034402.56721484
12RNA transport_Homo sapiens_hsa030132.43254131
13RNA degradation_Homo sapiens_hsa030182.28356766
14Cell cycle_Homo sapiens_hsa041102.23183700
15Non-homologous end-joining_Homo sapiens_hsa034502.04749712
16Fanconi anemia pathway_Homo sapiens_hsa034602.03827561
17Oxidative phosphorylation_Homo sapiens_hsa001901.98426833
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89291089
19Propanoate metabolism_Homo sapiens_hsa006401.86396610
20Pyrimidine metabolism_Homo sapiens_hsa002401.81100701
21Ribosome_Homo sapiens_hsa030101.79429631
22Parkinsons disease_Homo sapiens_hsa050121.74027729
23mRNA surveillance pathway_Homo sapiens_hsa030151.66608908
24Huntingtons disease_Homo sapiens_hsa050161.65490299
25Purine metabolism_Homo sapiens_hsa002301.62689899
26Steroid biosynthesis_Homo sapiens_hsa001001.56713992
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51678701
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38534442
29Synaptic vesicle cycle_Homo sapiens_hsa047211.34969125
30Selenocompound metabolism_Homo sapiens_hsa004501.28852888
31Nicotine addiction_Homo sapiens_hsa050331.28025083
32Oocyte meiosis_Homo sapiens_hsa041141.27690182
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27427065
34Protein export_Homo sapiens_hsa030601.24076889
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19981636
36Alzheimers disease_Homo sapiens_hsa050101.11979051
37Folate biosynthesis_Homo sapiens_hsa007901.05408775
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02868303
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95573147
40Epstein-Barr virus infection_Homo sapiens_hsa051690.90636202
41Butanoate metabolism_Homo sapiens_hsa006500.85264343
42Collecting duct acid secretion_Homo sapiens_hsa049660.85174354
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84980414
44One carbon pool by folate_Homo sapiens_hsa006700.84939708
45Vitamin B6 metabolism_Homo sapiens_hsa007500.81789857
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78327323
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77885271
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77436527
49Carbon metabolism_Homo sapiens_hsa012000.77163579
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74852174
51Serotonergic synapse_Homo sapiens_hsa047260.71269452
52GABAergic synapse_Homo sapiens_hsa047270.65254190
53Glutathione metabolism_Homo sapiens_hsa004800.64557644
54Dopaminergic synapse_Homo sapiens_hsa047280.63970809
55Caffeine metabolism_Homo sapiens_hsa002320.63715609
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.63200957
57Vibrio cholerae infection_Homo sapiens_hsa051100.62269360
58Peroxisome_Homo sapiens_hsa041460.61490153
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58565148
60Cardiac muscle contraction_Homo sapiens_hsa042600.56605256
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56450465
62p53 signaling pathway_Homo sapiens_hsa041150.55824000
63Morphine addiction_Homo sapiens_hsa050320.55070888
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53509080
65Alcoholism_Homo sapiens_hsa050340.51218427
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50498717
67Fatty acid metabolism_Homo sapiens_hsa012120.50139642
68Sulfur relay system_Homo sapiens_hsa041220.48902058
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47584479
70Olfactory transduction_Homo sapiens_hsa047400.46037697
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45807905
72beta-Alanine metabolism_Homo sapiens_hsa004100.45286558
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44459630
74Circadian rhythm_Homo sapiens_hsa047100.44409084
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40260754
76Fatty acid degradation_Homo sapiens_hsa000710.39514341
77Systemic lupus erythematosus_Homo sapiens_hsa053220.38616279
78N-Glycan biosynthesis_Homo sapiens_hsa005100.37361327
79Glutamatergic synapse_Homo sapiens_hsa047240.37230088
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35666269
81Metabolic pathways_Homo sapiens_hsa011000.34446584
82Tryptophan metabolism_Homo sapiens_hsa003800.34073200
83Vitamin digestion and absorption_Homo sapiens_hsa049770.33611099
84Pyruvate metabolism_Homo sapiens_hsa006200.33573658
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33396161
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33110439
87Ether lipid metabolism_Homo sapiens_hsa005650.32908867
88Circadian entrainment_Homo sapiens_hsa047130.32711318
89Taste transduction_Homo sapiens_hsa047420.31306348
90Retinol metabolism_Homo sapiens_hsa008300.31266805
91Nitrogen metabolism_Homo sapiens_hsa009100.30848389
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30784815
93Biosynthesis of amino acids_Homo sapiens_hsa012300.30729575
94Arachidonic acid metabolism_Homo sapiens_hsa005900.29596804
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.29551178
96Fructose and mannose metabolism_Homo sapiens_hsa000510.28321926
97Hedgehog signaling pathway_Homo sapiens_hsa043400.27922162
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26738445
99Arginine and proline metabolism_Homo sapiens_hsa003300.26120406
100Amphetamine addiction_Homo sapiens_hsa050310.26099991
101Fatty acid elongation_Homo sapiens_hsa000620.25336651
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25320282
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25294930
104Linoleic acid metabolism_Homo sapiens_hsa005910.24647806
105Cholinergic synapse_Homo sapiens_hsa047250.24562756
106Viral carcinogenesis_Homo sapiens_hsa052030.24169251
107Sulfur metabolism_Homo sapiens_hsa009200.23891510
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.23001486
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22992579
110Basal cell carcinoma_Homo sapiens_hsa052170.21901287
111Autoimmune thyroid disease_Homo sapiens_hsa053200.21126667
112TGF-beta signaling pathway_Homo sapiens_hsa043500.20440846
113Wnt signaling pathway_Homo sapiens_hsa043100.20046047
114HTLV-I infection_Homo sapiens_hsa051660.19658851
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19278256
116Pentose phosphate pathway_Homo sapiens_hsa000300.19194311
117Rheumatoid arthritis_Homo sapiens_hsa053230.18349038
118Hippo signaling pathway_Homo sapiens_hsa043900.17950398
119Herpes simplex infection_Homo sapiens_hsa051680.17527188
120Long-term potentiation_Homo sapiens_hsa047200.17375370
121Phagosome_Homo sapiens_hsa041450.16106132
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16053470
123Axon guidance_Homo sapiens_hsa043600.14139830
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13510829
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.13444052
126Type I diabetes mellitus_Homo sapiens_hsa049400.12843823
127Colorectal cancer_Homo sapiens_hsa052100.11647272
128Calcium signaling pathway_Homo sapiens_hsa040200.10999991
129Regulation of autophagy_Homo sapiens_hsa041400.09994409
130Long-term depression_Homo sapiens_hsa047300.09387592
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09189532
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08360339
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06555631
134Melanoma_Homo sapiens_hsa052180.05858067
135HIF-1 signaling pathway_Homo sapiens_hsa040660.05334819
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.04163568

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