GLO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.53417580
2L-phenylalanine catabolic process (GO:0006559)7.53417580
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.19236752
4L-phenylalanine metabolic process (GO:0006558)7.19236752
5aromatic amino acid family catabolic process (GO:0009074)6.37268073
6glyoxylate metabolic process (GO:0046487)5.84241418
7bile acid biosynthetic process (GO:0006699)5.68228369
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.42375496
9indole-containing compound catabolic process (GO:0042436)5.40779988
10indolalkylamine catabolic process (GO:0046218)5.40779988
11tryptophan catabolic process (GO:0006569)5.40779988
12alpha-linolenic acid metabolic process (GO:0036109)5.31639212
13kynurenine metabolic process (GO:0070189)5.31309063
14tryptophan metabolic process (GO:0006568)5.17907530
15cysteine metabolic process (GO:0006534)5.01464502
16sulfur amino acid catabolic process (GO:0000098)4.96222070
17negative regulation of fibrinolysis (GO:0051918)4.94954148
18high-density lipoprotein particle remodeling (GO:0034375)4.84003157
19regulation of protein activation cascade (GO:2000257)4.79802840
20DNA strand elongation involved in DNA replication (GO:0006271)4.74850767
21regulation of fibrinolysis (GO:0051917)4.74618722
22establishment of integrated proviral latency (GO:0075713)4.74587314
23peptidyl-glutamic acid carboxylation (GO:0017187)4.73753380
24protein carboxylation (GO:0018214)4.73753380
25bile acid metabolic process (GO:0008206)4.73555623
26aldehyde catabolic process (GO:0046185)4.71366872
27tyrosine metabolic process (GO:0006570)4.69727234
28aromatic amino acid family metabolic process (GO:0009072)4.68706238
29urea metabolic process (GO:0019627)4.65614945
30urea cycle (GO:0000050)4.65614945
31DNA unwinding involved in DNA replication (GO:0006268)4.62627606
32complement activation, alternative pathway (GO:0006957)4.61879892
33coenzyme catabolic process (GO:0009109)4.60829540
34DNA strand elongation (GO:0022616)4.58863029
35serine family amino acid catabolic process (GO:0009071)4.57709058
36regulation of complement activation (GO:0030449)4.49123240
37ethanol oxidation (GO:0006069)4.47439962
38cellular ketone body metabolic process (GO:0046950)4.44417651
39lysine metabolic process (GO:0006553)4.44061816
40lysine catabolic process (GO:0006554)4.44061816
41alpha-amino acid catabolic process (GO:1901606)4.41051675
42CENP-A containing nucleosome assembly (GO:0034080)4.38414177
43fatty acid elongation (GO:0030497)4.37570279
44nitrogen cycle metabolic process (GO:0071941)4.33861363
45telomere maintenance via semi-conservative replication (GO:0032201)4.33691190
46chromatin remodeling at centromere (GO:0031055)4.33486345
47protein localization to kinetochore (GO:0034501)4.31726053
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.30730906
49nuclear pore complex assembly (GO:0051292)4.27129462
50glycine metabolic process (GO:0006544)4.24776425
51regulation of cholesterol esterification (GO:0010872)4.23331264
52cellular glucuronidation (GO:0052695)4.23229816
53serine family amino acid biosynthetic process (GO:0009070)4.20249422
54mitotic sister chromatid segregation (GO:0000070)4.19533345
55homocysteine metabolic process (GO:0050667)4.18979365
56serine family amino acid metabolic process (GO:0009069)4.13920807
57reverse cholesterol transport (GO:0043691)4.13505012
58cellular amino acid catabolic process (GO:0009063)4.13424743
59purine nucleobase biosynthetic process (GO:0009113)4.12533323
60plasma lipoprotein particle remodeling (GO:0034369)4.09151650
61protein-lipid complex remodeling (GO:0034368)4.09151650
62macromolecular complex remodeling (GO:0034367)4.09151650
63triglyceride homeostasis (GO:0070328)4.08116827
64acylglycerol homeostasis (GO:0055090)4.08116827
65protein localization to chromosome, centromeric region (GO:0071459)4.07604491
66regulation of triglyceride catabolic process (GO:0010896)4.06653382
67cofactor catabolic process (GO:0051187)4.03879827
68DNA replication checkpoint (GO:0000076)4.02402514
69nuclear pore organization (GO:0006999)4.00739022
70amino-acid betaine metabolic process (GO:0006577)3.99924961
71glutamate metabolic process (GO:0006536)3.99864248
72acetyl-CoA metabolic process (GO:0006084)3.98827852
73sister chromatid segregation (GO:0000819)3.98438159
74bile acid and bile salt transport (GO:0015721)3.97544078
75indolalkylamine metabolic process (GO:0006586)3.95160080
76imidazole-containing compound metabolic process (GO:0052803)3.93402775
77heme transport (GO:0015886)3.89026637
78mitotic metaphase plate congression (GO:0007080)3.87749030
79glucuronate metabolic process (GO:0019585)3.87414622
80uronic acid metabolic process (GO:0006063)3.87414622
81ketone body metabolic process (GO:1902224)3.87373486
82very long-chain fatty acid metabolic process (GO:0000038)3.86016102
83mitotic chromosome condensation (GO:0007076)3.83812715
84aspartate family amino acid catabolic process (GO:0009068)3.81548219
85IMP biosynthetic process (GO:0006188)3.81362181
86cellular biogenic amine catabolic process (GO:0042402)3.81213647
87amine catabolic process (GO:0009310)3.81213647
88short-chain fatty acid metabolic process (GO:0046459)3.81201714
89benzene-containing compound metabolic process (GO:0042537)3.79569787
90negative regulation of sterol transport (GO:0032372)3.77036785
91negative regulation of cholesterol transport (GO:0032375)3.77036785
92cholesterol efflux (GO:0033344)3.74303963
93response to nitrosative stress (GO:0051409)3.73932017
94nucleobase biosynthetic process (GO:0046112)3.73807446
95phospholipid efflux (GO:0033700)3.73789098
96plasma lipoprotein particle clearance (GO:0034381)3.71795626
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69108790
98cellular modified amino acid catabolic process (GO:0042219)3.68955844
99carboxylic acid catabolic process (GO:0046395)3.66066772
100organic acid catabolic process (GO:0016054)3.66066772
101telomere maintenance via recombination (GO:0000722)3.64899219
102arginine metabolic process (GO:0006525)3.64277736
103ribosome assembly (GO:0042255)3.63450425
104establishment of viral latency (GO:0019043)3.60121964
105DNA replication-independent nucleosome organization (GO:0034724)3.59670257
106DNA replication-independent nucleosome assembly (GO:0006336)3.59670257
107mitotic recombination (GO:0006312)3.59603045
108very-low-density lipoprotein particle assembly (GO:0034379)3.55632290
109fibrinolysis (GO:0042730)3.54740704
110IMP metabolic process (GO:0046040)3.54293791
111L-serine metabolic process (GO:0006563)3.54162723
112DNA ligation (GO:0006266)3.50199656
113dicarboxylic acid biosynthetic process (GO:0043650)3.50122246
114cholesterol biosynthetic process (GO:0006695)3.49356194
115DNA replication initiation (GO:0006270)3.48915056
116histone exchange (GO:0043486)3.48580876
117proteasome assembly (GO:0043248)3.48185828
118formation of translation preinitiation complex (GO:0001731)3.47154494
119low-density lipoprotein particle remodeling (GO:0034374)3.45128268
120acyl-CoA metabolic process (GO:0006637)3.43482793
121thioester metabolic process (GO:0035383)3.43482793
122monocarboxylic acid catabolic process (GO:0072329)3.42824189
123ethanol metabolic process (GO:0006067)3.41417561
124ribosomal large subunit biogenesis (GO:0042273)3.41288195
125regulation of cholesterol metabolic process (GO:0090181)3.40552822
126negative regulation of protein activation cascade (GO:2000258)3.40052870
127maturation of SSU-rRNA (GO:0030490)3.39615691
128negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36935322
129regulation of cholesterol biosynthetic process (GO:0045540)3.35782330
130plasma lipoprotein particle assembly (GO:0034377)3.35567462
131fatty acid beta-oxidation (GO:0006635)3.35396818
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34718990
133regulation of bile acid biosynthetic process (GO:0070857)3.34674716
134fatty-acyl-CoA biosynthetic process (GO:0046949)3.34332873
135metaphase plate congression (GO:0051310)3.34040355
136fatty acid catabolic process (GO:0009062)3.33742185
137cytolysis (GO:0019835)3.32903314
138regulation of translational fidelity (GO:0006450)3.31096139
139regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.29493511
140nucleotide-excision repair, DNA gap filling (GO:0006297)3.28547056
141kinetochore organization (GO:0051383)3.23474142
142nucleobase-containing small molecule interconversion (GO:0015949)3.22779597
143mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.18159693
144spindle checkpoint (GO:0031577)3.17900970
145folic acid-containing compound biosynthetic process (GO:0009396)3.15735119
146mitotic nuclear envelope disassembly (GO:0007077)3.15693576
147pore complex assembly (GO:0046931)3.14804550
148protein complex localization (GO:0031503)3.14048212
149negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14026558
150negative regulation of ligase activity (GO:0051352)3.14026558
151double-strand break repair via nonhomologous end joining (GO:0006303)3.09239914
152non-recombinational repair (GO:0000726)3.09239914
153regulation of mitotic spindle organization (GO:0060236)3.07870245
154positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06984862
155negative regulation of chromosome segregation (GO:0051985)3.06256312
156regulation of chromosome segregation (GO:0051983)3.02889173
157mitotic sister chromatid cohesion (GO:0007064)3.02551959
158negative regulation of mitotic sister chromatid separation (GO:2000816)3.02077725
159negative regulation of sister chromatid segregation (GO:0033046)3.02077725
160negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02077725
161negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02077725
162negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02077725
163mitotic spindle checkpoint (GO:0071174)3.01879072
164DNA replication-dependent nucleosome organization (GO:0034723)2.99615668
165DNA replication-dependent nucleosome assembly (GO:0006335)2.99615668
166deoxyribonucleotide biosynthetic process (GO:0009263)2.98498407
167regulation of mitochondrial translation (GO:0070129)2.98190953
168regulation of spindle organization (GO:0090224)2.97038883
169tRNA aminoacylation for protein translation (GO:0006418)2.93648752
170spindle assembly checkpoint (GO:0071173)2.92862336
171mitotic spindle assembly checkpoint (GO:0007094)2.91610669
172DNA topological change (GO:0006265)2.90618484
173telomere maintenance via telomere lengthening (GO:0010833)2.90280611
174amino acid activation (GO:0043038)2.90007561
175tRNA aminoacylation (GO:0043039)2.90007561
176regulation of centriole replication (GO:0046599)2.89895013
177membrane disassembly (GO:0030397)2.89570260
178nuclear envelope disassembly (GO:0051081)2.89570260
179spliceosomal snRNP assembly (GO:0000387)2.88730386
180regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87821130
181ATP-dependent chromatin remodeling (GO:0043044)2.86238820
182heterochromatin organization (GO:0070828)2.86057171
183ribosomal small subunit assembly (GO:0000028)2.85594017
184cellular protein complex localization (GO:0034629)2.84860396
185oxidative phosphorylation (GO:0006119)2.83042470
186G1/S transition of mitotic cell cycle (GO:0000082)2.81688141
187cell cycle G1/S phase transition (GO:0044843)2.81688141
188regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81523997
189regulation of mitotic metaphase/anaphase transition (GO:0030071)2.81523997
190transcription-coupled nucleotide-excision repair (GO:0006283)2.81505633
191kinetochore assembly (GO:0051382)2.79274572
192establishment of chromosome localization (GO:0051303)2.79125739
193chromosome segregation (GO:0007059)2.78250219
194chromatin assembly or disassembly (GO:0006333)2.77245051
195ribonucleoprotein complex biogenesis (GO:0022613)2.75460056
196regulation of sister chromatid segregation (GO:0033045)2.71644471
197regulation of mitotic sister chromatid separation (GO:0010965)2.71644471
198regulation of mitotic sister chromatid segregation (GO:0033047)2.71644471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.70048294
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.25600670
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.44433950
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.16489252
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.49333136
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.93534968
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.63628333
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.57130904
9MYC_18555785_ChIP-Seq_MESCs_Mouse4.39618013
10E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02533106
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.93441372
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.91914180
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.37158145
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31840497
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23277959
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90151483
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83077947
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82789307
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.62540823
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.50032580
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44028603
22XRN2_22483619_ChIP-Seq_HELA_Human2.43780436
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35307633
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.27000925
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25441486
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25044575
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23382415
28DCP1A_22483619_ChIP-Seq_HELA_Human2.22329466
29ELK1_19687146_ChIP-ChIP_HELA_Human2.21849767
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.19091952
31TTF2_22483619_ChIP-Seq_HELA_Human2.14918060
32MYCN_18555785_ChIP-Seq_MESCs_Mouse2.11139843
33HTT_18923047_ChIP-ChIP_STHdh_Human2.06780783
34* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.03812414
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8230385
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97115618
37GABP_19822575_ChIP-Seq_HepG2_Human1.83953471
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82581486
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81099675
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78630161
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78465623
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78345712
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.78202513
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77612267
45* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72968786
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72776181
47* FOXP3_21729870_ChIP-Seq_TREG_Human1.71675612
48VDR_23849224_ChIP-Seq_CD4+_Human1.70780901
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56927659
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56063166
51CLOCK_20551151_ChIP-Seq_293T_Human1.54130263
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52927276
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49101542
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48167870
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41744929
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39405369
57KDM5A_27292631_Chip-Seq_BREAST_Human1.35581284
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29182419
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27390277
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27108198
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25063879
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23933069
63CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22202632
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.20920865
65MYC_18940864_ChIP-ChIP_HL60_Human1.20681566
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20125395
67* FOXA2_19822575_ChIP-Seq_HepG2_Human1.19348184
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.19112400
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18281761
70* HNF4A_19822575_ChIP-Seq_HepG2_Human1.17435614
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14229684
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13718339
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13392332
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11976110
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09776046
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08369380
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07867876
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06846173
79TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06442979
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05647714
81* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04158730
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.04008094
83TAF15_26573619_Chip-Seq_HEK293_Human1.03814673
84RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99692419
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99228467
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98701096
87CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96287528
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95558754
89NANOG_21062744_ChIP-ChIP_HESCs_Human0.95321723
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92055512
91SRF_21415370_ChIP-Seq_HL-1_Mouse0.91759732
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89637770
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88661264
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88233649
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88197122
96IRF1_19129219_ChIP-ChIP_H3396_Human0.86769380
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.86399589
98* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86152919
99* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86059280
100CHD1_26751641_Chip-Seq_LNCaP_Human0.85770454
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84162535
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84063483
103* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83238561
104SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82832712
105E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82324229
106SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81670933
107TFEB_21752829_ChIP-Seq_HELA_Human0.81510333
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81140238
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81140138
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81140138
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80158933
112CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.77356285
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.77341782
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77252724
115EWS_26573619_Chip-Seq_HEK293_Human0.76438552
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76329851
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76260653
118* SOX17_20123909_ChIP-Seq_XEN_Mouse0.75614523
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75002848
120GATA1_22025678_ChIP-Seq_K562_Human0.74180391
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74082343
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72067224
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.70302219
124* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.67669753
125* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67108684
126* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66932636
127OCT4_18692474_ChIP-Seq_MEFs_Mouse0.66824268
128GABP_17652178_ChIP-ChIP_JURKAT_Human0.66625493
129VDR_22108803_ChIP-Seq_LS180_Human0.66608879
130* NCOR_22424771_ChIP-Seq_293T_Human0.66052952
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65502428
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.63827686
133* GATA4_25053715_ChIP-Seq_YYC3_Human0.63360323
134* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63188713
135ZNF263_19887448_ChIP-Seq_K562_Human0.62623075
136EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.62291240
137EST1_17652178_ChIP-ChIP_JURKAT_Human0.62191215
138AR_20517297_ChIP-Seq_VCAP_Human0.61959422
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.61342224
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.61305595
141CBP_21632823_ChIP-Seq_H3396_Human0.59993729
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59347769
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.57038219
144REST_19997604_ChIP-ChIP_NEURONS_Mouse0.57008979
145NANOG_18692474_ChIP-Seq_MEFs_Mouse0.56558481
146CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.56410316
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.56015717
148* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54870849
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.54852564
150RARA_24833708_ChIP-Seq_LIVER_Mouse0.54738384
151RBPJ_22232070_ChIP-Seq_NCS_Mouse0.54636797
152POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.54088980
153RARG_19884340_ChIP-ChIP_MEFs_Mouse0.53457681
154ERG_20517297_ChIP-Seq_VCAP_Human0.53052999
155BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.52408903
156SOX2_19829295_ChIP-Seq_ESCs_Human0.51893934
157NANOG_19829295_ChIP-Seq_ESCs_Human0.51893934
158* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.51175166
159RARB_24833708_ChIP-Seq_LIVER_Mouse0.50488530
160MYC_19915707_ChIP-ChIP_AK7_Human0.49453474
161AR_21909140_ChIP-Seq_LNCAP_Human0.48432398
162GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.48053403
163TCF3_18692474_ChIP-Seq_MESCs_Mouse0.47765526
164EOMES_21245162_ChIP-Seq_HESCs_Human0.47506531
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.47315469
166SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.47130653
167ERG_21242973_ChIP-ChIP_JURKAT_Human0.47019537
168PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.46748586
169ETV2_25802403_ChIP-Seq_MESCs_Mouse0.45709448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.79145599
2MP0005360_urolithiasis6.85978378
3MP0005085_abnormal_gallbladder_physiolo6.03439051
4MP0003806_abnormal_nucleotide_metabolis5.92009233
5MP0005365_abnormal_bile_salt5.54443712
6MP0008875_abnormal_xenobiotic_pharmacok4.82413472
7MP0010094_abnormal_chromosome_stability4.38097842
8MP0003693_abnormal_embryo_hatching3.98753494
9MP0003111_abnormal_nucleus_morphology3.87786886
10MP0004957_abnormal_blastocyst_morpholog3.80825719
11MP0003077_abnormal_cell_cycle3.34357755
12MP0003252_abnormal_bile_duct3.34248494
13MP0008932_abnormal_embryonic_tissue3.21262582
14MP0003195_calcinosis3.16269683
15MP0008058_abnormal_DNA_repair3.13291052
16MP0010329_abnormal_lipoprotein_level3.02107380
17MP0005083_abnormal_biliary_tract2.91868764
18MP0005332_abnormal_amino_acid2.70733586
19MP0008057_abnormal_DNA_replication2.67778477
20MP0009840_abnormal_foam_cell2.58305734
21MP0008007_abnormal_cellular_replicative2.50936369
22MP0001666_abnormal_nutrient_absorption2.42379253
23MP0003011_delayed_dark_adaptation2.40082889
24MP0003941_abnormal_skin_development2.11890440
25MP0000537_abnormal_urethra_morphology2.03208956
26MP0009697_abnormal_copulation2.01965034
27MP0004019_abnormal_vitamin_homeostasis1.94039352
28MP0002118_abnormal_lipid_homeostasis1.90410425
29MP0001730_embryonic_growth_arrest1.87481091
30MP0001293_anophthalmia1.81352712
31MP0000350_abnormal_cell_proliferation1.80016232
32MP0001764_abnormal_homeostasis1.78522082
33MP0000609_abnormal_liver_physiology1.69459128
34MP0003786_premature_aging1.68188596
35MP0003186_abnormal_redox_activity1.66758657
36MP0003315_abnormal_perineum_morphology1.66631964
37MP0005380_embryogenesis_phenotype1.64101853
38MP0001672_abnormal_embryogenesis/_devel1.64101853
39MP0003868_abnormal_feces_composition1.62355262
40MP0002938_white_spotting1.58847613
41MP0005319_abnormal_enzyme/_coenzyme1.58694990
42MP0003937_abnormal_limbs/digits/tail_de1.58118547
43MP0001697_abnormal_embryo_size1.57456641
44MP0005584_abnormal_enzyme/coenzyme_acti1.56401981
45MP0003191_abnormal_cellular_cholesterol1.54957924
46MP0003890_abnormal_embryonic-extraembry1.53793742
47MP0001346_abnormal_lacrimal_gland1.53202571
48MP0002697_abnormal_eye_size1.52332073
49MP0006292_abnormal_olfactory_placode1.49494426
50MP0002085_abnormal_embryonic_tissue1.47002070
51MP0003656_abnormal_erythrocyte_physiolo1.45738490
52MP0002084_abnormal_developmental_patter1.45468414
53MP0003984_embryonic_growth_retardation1.44872623
54MP0009672_abnormal_birth_weight1.41094401
55MP0003567_abnormal_fetal_cardiomyocyte1.40237615
56MP0002080_prenatal_lethality1.39818305
57MP0005187_abnormal_penis_morphology1.39238367
58MP0002088_abnormal_embryonic_growth/wei1.39075241
59MP0002877_abnormal_melanocyte_morpholog1.35644784
60MP0006036_abnormal_mitochondrial_physio1.35545294
61MP0010352_gastrointestinal_tract_polyps1.35187577
62MP0002234_abnormal_pharynx_morphology1.33554454
63MP0001286_abnormal_eye_development1.27927201
64MP0002138_abnormal_hepatobiliary_system1.22184941
65MP0004233_abnormal_muscle_weight1.20256743
66MP0003136_yellow_coat_color1.18387472
67MP0000647_abnormal_sebaceous_gland1.17898486
68MP0002822_catalepsy1.17154336
69MP0005551_abnormal_eye_electrophysiolog1.17000650
70MP0005408_hypopigmentation1.15272818
71MP0000358_abnormal_cell_content/1.11105288
72MP0009643_abnormal_urine_homeostasis1.10908588
73MP0010307_abnormal_tumor_latency1.10709016
74MP0002092_abnormal_eye_morphology1.09722353
75MP0002111_abnormal_tail_morphology1.08262232
76MP0010234_abnormal_vibrissa_follicle1.07600396
77MP0003221_abnormal_cardiomyocyte_apopto1.07529193
78MP0002233_abnormal_nose_morphology1.06995091
79MP0006035_abnormal_mitochondrial_morpho1.05196887
80MP0000313_abnormal_cell_death1.05175853
81MP0004197_abnormal_fetal_growth/weight/1.04724651
82MP0003942_abnormal_urinary_system1.03826319
83MP0005636_abnormal_mineral_homeostasis1.03707063
84MP0003123_paternal_imprinting1.02900493
85MP0005266_abnormal_metabolism1.01998174
86MP0003329_amyloid_beta_deposits0.99586688
87MP0002837_dystrophic_cardiac_calcinosis0.97721327
88MP0005451_abnormal_body_composition0.97184199
89MP0005623_abnormal_meninges_morphology0.97076402
90MP0005647_abnormal_sex_gland0.97004788
91MP0002009_preneoplasia0.96689010
92MP0000604_amyloidosis0.96443906
93MP0005171_absent_coat_pigmentation0.95531909
94MP0000372_irregular_coat_pigmentation0.95218885
95MP0005376_homeostasis/metabolism_phenot0.94827124
96MP0002086_abnormal_extraembryonic_tissu0.93928064
97MP0003385_abnormal_body_wall0.89590255
98MP0003119_abnormal_digestive_system0.88843299
99MP0004043_abnormal_pH_regulation0.88385573
100MP0001299_abnormal_eye_distance/0.87825908
101MP0000598_abnormal_liver_morphology0.87435374
102MP0002210_abnormal_sex_determination0.86564090
103MP0001661_extended_life_span0.86527366
104MP0003755_abnormal_palate_morphology0.83734381
105MP0008789_abnormal_olfactory_epithelium0.83066330
106MP0004272_abnormal_basement_membrane0.82784391
107MP0000762_abnormal_tongue_morphology0.81654104
108MP0003861_abnormal_nervous_system0.80164479
109MP0003690_abnormal_glial_cell0.79935092
110MP0009703_decreased_birth_body0.79663969
111MP0009053_abnormal_anal_canal0.79535489
112MP0001727_abnormal_embryo_implantation0.78095224
113MP0002160_abnormal_reproductive_system0.77660849
114MP0001145_abnormal_male_reproductive0.75842646
115MP0003718_maternal_effect0.75215911
116MP0005501_abnormal_skin_physiology0.73820560
117MP0000579_abnormal_nail_morphology0.73643846
118MP0004185_abnormal_adipocyte_glucose0.73025542
119MP0005391_vision/eye_phenotype0.72217660
120MP0001929_abnormal_gametogenesis0.72017140
121MP0004147_increased_porphyrin_level0.71718820
122MP0005220_abnormal_exocrine_pancreas0.71051889
123MP0009765_abnormal_xenobiotic_induced0.70346486
124MP0009763_increased_sensitivity_to0.69961861
125MP0003950_abnormal_plasma_membrane0.69509141
126MP0000049_abnormal_middle_ear0.69409853
127MP0000428_abnormal_craniofacial_morphol0.68731155
128MP0004142_abnormal_muscle_tone0.68525216
129MP0000653_abnormal_sex_gland0.68273401
130MP0002078_abnormal_glucose_homeostasis0.66757153
131MP0003935_abnormal_craniofacial_develop0.65616208
132MP0000639_abnormal_adrenal_gland0.65044931
133MP0009642_abnormal_blood_homeostasis0.64950803
134MP0005197_abnormal_uvea_morphology0.64185891
135MP0005084_abnormal_gallbladder_morpholo0.62137986
136MP0001529_abnormal_vocalization0.62043728
137MP0005384_cellular_phenotype0.61939432
138MP0003121_genomic_imprinting0.61086385
139MP0002090_abnormal_vision0.60276567
140MP0005535_abnormal_body_temperature0.59445163
141MP0000920_abnormal_myelination0.59424734
142MP0005253_abnormal_eye_physiology0.58558062
143MP0009379_abnormal_foot_pigmentation0.57195740
144MP0010368_abnormal_lymphatic_system0.57053862
145MP0001756_abnormal_urination0.54387403
146MP0002876_abnormal_thyroid_physiology0.53900771
147MP0005395_other_phenotype0.53677866
148MP0002229_neurodegeneration0.53090493
149MP0005248_abnormal_Harderian_gland0.51588413
150MP0005195_abnormal_posterior_eye0.50990280
151MP0008872_abnormal_physiological_respon0.50296727
152MP0003632_abnormal_nervous_system0.47750061
153MP0001984_abnormal_olfaction0.47088320
154MP0009764_decreased_sensitivity_to0.46352370
155MP0002254_reproductive_system_inflammat0.44007041
156MP0002269_muscular_atrophy0.43599710
157MP0003705_abnormal_hypodermis_morpholog0.43542661
158MP0000566_synostosis0.43324195
159MP0000230_abnormal_systemic_arterial0.42819395
160MP0001324_abnormal_eye_pigmentation0.42196353
161MP0003638_abnormal_response/metabolism_0.41687891
162MP0002796_impaired_skin_barrier0.40845225
163MP0006072_abnormal_retinal_apoptosis0.40456587
164MP0005334_abnormal_fat_pad0.40398820
165MP0002295_abnormal_pulmonary_circulatio0.40166988
166MP0002971_abnormal_brown_adipose0.39856655
167MP0004782_abnormal_surfactant_physiolog0.39442646
168MP0009384_cardiac_valve_regurgitation0.37296496
169MP0010030_abnormal_orbit_morphology0.36974841
170MP0004133_heterotaxia0.36587671
171MP0002332_abnormal_exercise_endurance0.36221324
172MP0008469_abnormal_protein_level0.35720035
173MP0008873_increased_physiological_sensi0.35102812
174MP0005670_abnormal_white_adipose0.35084683
175MP0006276_abnormal_autonomic_nervous0.34273990
176MP0003953_abnormal_hormone_level0.33496383
177MP0004381_abnormal_hair_follicle0.33349314
178MP0005448_abnormal_energy_balance0.32326090
179MP0005330_cardiomyopathy0.31766114
180MP0004036_abnormal_muscle_relaxation0.31724891
181MP0004130_abnormal_muscle_cell0.31361331

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.97909011
2Intrahepatic cholestasis (HP:0001406)6.88460850
3Hypobetalipoproteinemia (HP:0003563)6.19268893
4Deep venous thrombosis (HP:0002625)6.16587576
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.89397237
6Prolonged partial thromboplastin time (HP:0003645)5.55716444
7Xanthomatosis (HP:0000991)5.34526772
8Hyperlipoproteinemia (HP:0010980)4.89997823
9Hyperglycinemia (HP:0002154)4.39664981
10Complement deficiency (HP:0004431)4.36976048
11Chromosomal breakage induced by crosslinking agents (HP:0003221)4.35492863
12Hyperammonemia (HP:0001987)4.32013597
13Hypolipoproteinemia (HP:0010981)4.31813190
14Abnormality of methionine metabolism (HP:0010901)4.11218376
15Chromsome breakage (HP:0040012)4.01219381
16Fat malabsorption (HP:0002630)3.96631143
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.94018949
18Ketosis (HP:0001946)3.90312628
19Abnormality of aspartate family amino acid metabolism (HP:0010899)3.88874182
20Abnormality of glycine metabolism (HP:0010895)3.87721348
21Abnormality of serine family amino acid metabolism (HP:0010894)3.87721348
22Epidermoid cyst (HP:0200040)3.76856984
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.72403018
24Hypoglycemic coma (HP:0001325)3.68817345
25Hyperglycinuria (HP:0003108)3.61012356
26Abnormality of the common coagulation pathway (HP:0010990)3.56791355
27Conjugated hyperbilirubinemia (HP:0002908)3.51855927
28Cerebral edema (HP:0002181)3.45102817
29Joint hemorrhage (HP:0005261)3.40018679
30Hypoalphalipoproteinemia (HP:0003233)3.38701442
31Reticulocytopenia (HP:0001896)3.26618228
32Hyperbilirubinemia (HP:0002904)3.22318149
33Abnormality of fatty-acid metabolism (HP:0004359)3.21904942
34Abnormality of glutamine family amino acid metabolism (HP:0010902)3.20729407
35Steatorrhea (HP:0002570)3.16887051
36Abnormality of the intrinsic pathway (HP:0010989)3.12915974
37Increased serum pyruvate (HP:0003542)3.11630769
38Abnormality of glycolysis (HP:0004366)3.11630769
39Meckel diverticulum (HP:0002245)3.10628858
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.10593722
41Abnormality of pyrimidine metabolism (HP:0004353)3.09664797
42Delayed CNS myelination (HP:0002188)3.03937126
43Lethargy (HP:0001254)3.02706261
44Abnormality of serum amino acid levels (HP:0003112)2.99322852
45Abnormality of complement system (HP:0005339)2.99122153
46Birth length less than 3rd percentile (HP:0003561)2.98204160
47Abnormal gallbladder physiology (HP:0012438)2.96297518
48Cholecystitis (HP:0001082)2.96297518
49Ketoacidosis (HP:0001993)2.91727548
50Abnormality of the ileum (HP:0001549)2.90584055
51Acute encephalopathy (HP:0006846)2.85877829
52Hypercholesterolemia (HP:0003124)2.85154280
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.78942767
54Metabolic acidosis (HP:0001942)2.78078095
55Cortical dysplasia (HP:0002539)2.76461938
56Abnormality of the preputium (HP:0100587)2.73675022
57Abnormality of chromosome stability (HP:0003220)2.73008175
58Microvesicular hepatic steatosis (HP:0001414)2.72528497
59Abnormal gallbladder morphology (HP:0012437)2.70419235
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65950935
61Dicarboxylic aciduria (HP:0003215)2.65950935
62Hypochromic microcytic anemia (HP:0004840)2.65330108
63Increased nuchal translucency (HP:0010880)2.63814816
64Abnormal lung lobation (HP:0002101)2.61093230
65Cholelithiasis (HP:0001081)2.58942300
66Hepatocellular carcinoma (HP:0001402)2.47337775
67Abnormality of the anterior horn cell (HP:0006802)2.45538256
68Degeneration of anterior horn cells (HP:0002398)2.45538256
69Abnormality of nucleobase metabolism (HP:0010932)2.43473952
70Macrocytic anemia (HP:0001972)2.42849052
71Multiple enchondromatosis (HP:0005701)2.42319738
72Increased hepatocellular lipid droplets (HP:0006565)2.39707021
73Vascular calcification (HP:0004934)2.39539363
74Spastic diplegia (HP:0001264)2.39455979
75Hepatic necrosis (HP:0002605)2.39166693
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38790525
77Duodenal stenosis (HP:0100867)2.38485352
78Small intestinal stenosis (HP:0012848)2.38485352
79Vomiting (HP:0002013)2.35476458
80Skin nodule (HP:0200036)2.31802647
81Spontaneous abortion (HP:0005268)2.31267801
82Brushfield spots (HP:0001088)2.30906916
83Abnormality of the umbilical cord (HP:0010881)2.30845710
84Irritability (HP:0000737)2.30657888
85Hypoglycemic seizures (HP:0002173)2.29699022
86Nephroblastoma (Wilms tumor) (HP:0002667)2.29385989
87Abnormality of the fetal cardiovascular system (HP:0010948)2.28751678
88Abnormal umbilical cord blood vessels (HP:0011403)2.28751678
89Single umbilical artery (HP:0001195)2.28751678
90Acanthocytosis (HP:0001927)2.27555146
91Abnormality of alanine metabolism (HP:0010916)2.25124121
92Hyperalaninemia (HP:0003348)2.25124121
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25124121
94Acute necrotizing encephalopathy (HP:0006965)2.22622013
95Abnormality of the gallbladder (HP:0005264)2.18958352
96Triphalangeal thumb (HP:0001199)2.16447988
97Opisthotonus (HP:0002179)2.16018390
98Abnormal mitochondria in muscle tissue (HP:0008316)2.15321761
99Malnutrition (HP:0004395)2.13780116
100Embryonal renal neoplasm (HP:0011794)2.13736525
101Glycosuria (HP:0003076)2.11560803
102Abnormality of urine glucose concentration (HP:0011016)2.11560803
103Enlarged kidneys (HP:0000105)2.10854348
104Facial cleft (HP:0002006)2.10747287
105Gout (HP:0001997)2.10514345
106Abnormality of purine metabolism (HP:0004352)2.10378529
107Abnormality of the carotid arteries (HP:0005344)2.10128260
108Cardiovascular calcification (HP:0011915)2.09332346
109Proximal placement of thumb (HP:0009623)2.07467904
110Exercise-induced muscle cramps (HP:0003710)2.06743135
111Increased serum lactate (HP:0002151)2.04576432
112Generalized aminoaciduria (HP:0002909)2.03086029
113Abnormality of the duodenum (HP:0002246)2.02429795
114Absent radius (HP:0003974)2.02221157
115Hyperinsulinemic hypoglycemia (HP:0000825)2.02205770
116Abnormalities of placenta or umbilical cord (HP:0001194)2.01421639
117Colon cancer (HP:0003003)2.01107280
118Rickets (HP:0002748)1.98492878
119Hepatocellular necrosis (HP:0001404)1.97796366
120Chorioretinal atrophy (HP:0000533)1.97011676
121Neonatal onset (HP:0003623)1.96939928
122Sensorimotor neuropathy (HP:0007141)1.96737058
123Hypophosphatemic rickets (HP:0004912)1.96679375
124Renal cortical cysts (HP:0000803)1.96547172
125Postnatal microcephaly (HP:0005484)1.95755503
126Deviation of the thumb (HP:0009603)1.95332180
127Abnormality of vitamin metabolism (HP:0100508)1.94890127
128Myelodysplasia (HP:0002863)1.94783011
129Spastic paraparesis (HP:0002313)1.94263198
130Megaloblastic anemia (HP:0001889)1.93282607
131Abnormal cartilage morphology (HP:0002763)1.92885645
132Hypoplastic pelvis (HP:0008839)1.92022274
133Aplasia involving forearm bones (HP:0009822)1.91896677
134Absent forearm bone (HP:0003953)1.91896677
135Reduced antithrombin III activity (HP:0001976)1.91423787
136Type I transferrin isoform profile (HP:0003642)1.89812507
137Alkalosis (HP:0001948)1.89730494
138Medulloblastoma (HP:0002885)1.88324900
139Mitochondrial inheritance (HP:0001427)1.87800681
140Increased CSF lactate (HP:0002490)1.87515577
141Progressive muscle weakness (HP:0003323)1.86870248
142Selective tooth agenesis (HP:0001592)1.86215889
143Exercise intolerance (HP:0003546)1.84902785
144Progressive macrocephaly (HP:0004481)1.84662239
145Lactic acidosis (HP:0003128)1.84009878
146Abnormality of cochlea (HP:0000375)1.81602322
147Volvulus (HP:0002580)1.80010860
148Leukodystrophy (HP:0002415)1.79505476
149Abnormality of cells of the erythroid lineage (HP:0012130)1.78892900
150Secondary amenorrhea (HP:0000869)1.78875358
151Delayed myelination (HP:0012448)1.78633206
152Duplication of thumb phalanx (HP:0009942)1.78341235
153Horseshoe kidney (HP:0000085)1.77311607
154Systemic lupus erythematosus (HP:0002725)1.77028286
155Abnormality of the labia minora (HP:0012880)1.76241371
156CNS demyelination (HP:0007305)1.75879990
157Late onset (HP:0003584)1.75316561
158Microglossia (HP:0000171)1.74750058
159Increased intramyocellular lipid droplets (HP:0012240)1.74263631
160Choanal atresia (HP:0000453)1.73984592
161Lipid accumulation in hepatocytes (HP:0006561)1.73850227
162Pigmentary retinal degeneration (HP:0001146)1.73631684
163Poikilocytosis (HP:0004447)1.72090965
164Neoplasm of the colon (HP:0100273)1.68327774
165Sloping forehead (HP:0000340)1.66675207
166Neoplasm of the adrenal gland (HP:0100631)1.65553183
167Bifid tongue (HP:0010297)1.63975953
168Decreased activity of mitochondrial respiratory chain (HP:0008972)1.63965094
169Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.63965094
170Progressive external ophthalmoplegia (HP:0000590)1.59532612
171High anterior hairline (HP:0009890)1.56998356
172Ependymoma (HP:0002888)1.53571484
173Overlapping toe (HP:0001845)1.52848021
174Abnormal number of erythroid precursors (HP:0012131)1.51592275
175Ectopic kidney (HP:0000086)1.51198867

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.87365329
2PBK3.73361277
3SRPK13.59474837
4CDC73.54374150
5TTK3.19955667
6ERBB42.96693555
7WEE12.88783066
8TSSK62.84864687
9STK392.57833976
10VRK22.52940058
11SIK12.31825342
12PLK32.19373711
13TAOK32.18989220
14PLK42.14045465
15TESK22.00603741
16NME22.00361524
17MAP2K41.95838427
18FGFR41.92120830
19MET1.90115859
20INSRR1.83057094
21STK38L1.80207203
22BCR1.76608847
23BRSK21.74901666
24LIMK11.74544337
25PIK3CG1.72015460
26MKNK11.70662751
27PLK11.68515854
28SCYL21.67234367
29EIF2AK11.65458264
30TRIM281.64976793
31OXSR11.62136652
32WNK41.61751821
33FGFR21.59665731
34ZAK1.58055073
35BRSK11.55095495
36STK161.54293013
37PINK11.52934015
38NEK11.51562579
39CHEK21.47173834
40ABL21.44002375
41SGK2231.43151695
42SGK4941.43151695
43AURKB1.36909892
44PAK41.34344619
45OBSCN1.32678082
46EPHB11.28279917
47VRK11.28190438
48CAMK2G1.26643390
49ATR1.26005713
50KDR1.25749227
51MYLK1.24861803
52FLT31.22882253
53TAF11.18028429
54MKNK21.17528566
55NEK91.16481694
56ERN11.15925522
57CSNK1G31.15533376
58CDK71.14117961
59MST1R1.10879317
60PKN11.08275827
61ERBB31.04159710
62EIF2AK20.99704901
63AKT30.99383809
64NEK20.98907284
65PNCK0.95906695
66NME10.95657561
67MAPK110.94803529
68MAPK150.93726980
69CCNB10.93281244
70GRK10.92996527
71WNK30.92912917
72CHEK10.92873065
73LMTK20.92596265
74PLK20.92091760
75RPS6KA40.91269907
76FRK0.89948840
77CDK80.86340108
78PIK3CA0.84567740
79ERBB20.83203134
80PAK30.82922815
81PDK40.82606223
82PDK30.82606223
83CSNK1G10.82132104
84EIF2AK30.80165227
85CASK0.79064495
86ATM0.76616501
87PRKCZ0.76155017
88DYRK20.75760921
89CDK60.75643643
90CSNK1G20.74769713
91LATS20.74234495
92NUAK10.74048450
93RPS6KB20.73043394
94NTRK10.72872149
95STK40.72541416
96PRKACG0.71501363
97BRAF0.71373973
98CAMK2D0.71272340
99SMG10.69653087
100PDK20.69252216
101MAP3K80.69077789
102CAMK2B0.68978693
103ARAF0.68761083
104GSK3A0.67245041
105EPHA20.65728262
106DAPK20.64488132
107CSNK1A1L0.62631276
108EEF2K0.61652787
109CDK180.61543735
110IRAK20.60256747
111PHKG10.59521192
112PHKG20.59521192
113CDK10.59329097
114STK30.59211397
115PRKD30.58424233
116ALK0.57038222
117CDK150.56820167
118BUB10.56189077
119PRKCG0.56055156
120PRKACA0.54521356
121CDK11A0.53769333
122CDK20.53448996
123MAP2K10.51952249
124TLK10.51600612
125IRAK30.51471659
126AURKA0.50948926
127PRKACB0.50221156
128MAP3K120.50172858
129MAP3K100.50167329
130LATS10.49948463
131AKT20.49886507
132ADRBK10.49268749
133MAPK40.48883762
134MAP3K40.48500302
135UHMK10.46897046
136MST40.46335216
137MAPK120.46063125
138MAPKAPK50.45758774
139FGFR10.44965438
140DAPK10.43755976
141PRKCA0.43591171
142ILK0.42652153
143TESK10.42245746
144MAP2K60.42052959
145DYRK30.41422007
146CSNK1E0.40902827
147MAP3K30.40873640
148* CAMK2A0.40009176
149CLK10.39992965
150ROCK20.39423009
151PRKAA20.39334791
152PKN20.38743667
153MINK10.37741054
154EPHB20.37451277
155CDK40.37386578
156CDK30.37105489
157CSNK2A10.36971273
158CSNK2A20.36856959
159PASK0.36372684
160PRKAA10.36294540
161SGK20.36086477
162DAPK30.35910477
163CDK140.35685306
164PRKDC0.35048522
165ICK0.34949040
166STK100.31588192

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.07062887
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.94863901
3Mismatch repair_Homo sapiens_hsa034303.63467156
4Nitrogen metabolism_Homo sapiens_hsa009103.12199749
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94069236
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.93997241
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.72994254
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68487882
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57657615
10Ribosome_Homo sapiens_hsa030102.54062423
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51776711
12Arginine biosynthesis_Homo sapiens_hsa002202.51387090
13Tryptophan metabolism_Homo sapiens_hsa003802.40272172
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39303993
15Fatty acid degradation_Homo sapiens_hsa000712.39217993
16Butanoate metabolism_Homo sapiens_hsa006502.37204396
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35037771
18Nucleotide excision repair_Homo sapiens_hsa034202.34951372
19Spliceosome_Homo sapiens_hsa030402.33576869
20Non-homologous end-joining_Homo sapiens_hsa034502.32067882
21Base excision repair_Homo sapiens_hsa034102.31514674
22Homologous recombination_Homo sapiens_hsa034402.23418611
23Cell cycle_Homo sapiens_hsa041102.21857682
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17877286
25Propanoate metabolism_Homo sapiens_hsa006402.16098194
26Complement and coagulation cascades_Homo sapiens_hsa046102.16011008
27RNA transport_Homo sapiens_hsa030132.14494489
28Fatty acid elongation_Homo sapiens_hsa000622.12086900
29Peroxisome_Homo sapiens_hsa041462.05913375
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97570456
31Steroid biosynthesis_Homo sapiens_hsa001001.94594442
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93861280
33Chemical carcinogenesis_Homo sapiens_hsa052041.91647723
34Fanconi anemia pathway_Homo sapiens_hsa034601.89477009
35Histidine metabolism_Homo sapiens_hsa003401.88249534
36Fatty acid metabolism_Homo sapiens_hsa012121.86975328
37Sulfur metabolism_Homo sapiens_hsa009201.79672038
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.78776419
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76583688
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75811255
41RNA polymerase_Homo sapiens_hsa030201.75749930
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73807295
43Retinol metabolism_Homo sapiens_hsa008301.67347582
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.66406301
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62536096
46* Pyruvate metabolism_Homo sapiens_hsa006201.59209415
47beta-Alanine metabolism_Homo sapiens_hsa004101.58309300
48Tyrosine metabolism_Homo sapiens_hsa003501.55526159
49PPAR signaling pathway_Homo sapiens_hsa033201.55029383
50Phenylalanine metabolism_Homo sapiens_hsa003601.50541446
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42727990
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.39105747
53Carbon metabolism_Homo sapiens_hsa012001.35187906
54Selenocompound metabolism_Homo sapiens_hsa004501.33649016
55Biosynthesis of amino acids_Homo sapiens_hsa012301.32708055
56RNA degradation_Homo sapiens_hsa030181.32432718
57Folate biosynthesis_Homo sapiens_hsa007901.29764390
58Bile secretion_Homo sapiens_hsa049761.27813641
59Basal transcription factors_Homo sapiens_hsa030221.24484541
60mRNA surveillance pathway_Homo sapiens_hsa030151.20244419
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19297850
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18069558
63Starch and sucrose metabolism_Homo sapiens_hsa005001.15909940
64Caffeine metabolism_Homo sapiens_hsa002321.13854711
65Arginine and proline metabolism_Homo sapiens_hsa003301.10867523
66Fat digestion and absorption_Homo sapiens_hsa049751.06581754
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04308944
68Cyanoamino acid metabolism_Homo sapiens_hsa004601.02635570
69Maturity onset diabetes of the young_Homo sapiens_hsa049501.01205306
70Glutathione metabolism_Homo sapiens_hsa004800.98843005
71Vitamin B6 metabolism_Homo sapiens_hsa007500.96964546
72Staphylococcus aureus infection_Homo sapiens_hsa051500.96528076
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94763715
74Oocyte meiosis_Homo sapiens_hsa041140.94028814
75ABC transporters_Homo sapiens_hsa020100.93309750
76Sulfur relay system_Homo sapiens_hsa041220.88317333
77Oxidative phosphorylation_Homo sapiens_hsa001900.86039266
78p53 signaling pathway_Homo sapiens_hsa041150.84885113
79One carbon pool by folate_Homo sapiens_hsa006700.82789478
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80692085
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73082882
82Parkinsons disease_Homo sapiens_hsa050120.70729114
83Vitamin digestion and absorption_Homo sapiens_hsa049770.69844002
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67595983
85Metabolic pathways_Homo sapiens_hsa011000.67425890
86N-Glycan biosynthesis_Homo sapiens_hsa005100.66145943
87Thyroid cancer_Homo sapiens_hsa052160.60842800
88Pentose phosphate pathway_Homo sapiens_hsa000300.56192064
89Hippo signaling pathway_Homo sapiens_hsa043900.55298931
90Glycerolipid metabolism_Homo sapiens_hsa005610.53471526
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50460175
92Basal cell carcinoma_Homo sapiens_hsa052170.49179191
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45223290
94Lysine degradation_Homo sapiens_hsa003100.44829266
95Linoleic acid metabolism_Homo sapiens_hsa005910.43027695
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42737466
97Fatty acid biosynthesis_Homo sapiens_hsa000610.41728097
98Alzheimers disease_Homo sapiens_hsa050100.41149512
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.36295711
100Protein export_Homo sapiens_hsa030600.35965140
101Adherens junction_Homo sapiens_hsa045200.35302717
102Alcoholism_Homo sapiens_hsa050340.33869605
103Proteasome_Homo sapiens_hsa030500.33818063
104TGF-beta signaling pathway_Homo sapiens_hsa043500.31850860
105Prion diseases_Homo sapiens_hsa050200.31656187
106Huntingtons disease_Homo sapiens_hsa050160.31297833
107Hedgehog signaling pathway_Homo sapiens_hsa043400.30296728
108Galactose metabolism_Homo sapiens_hsa000520.29897358
109Fructose and mannose metabolism_Homo sapiens_hsa000510.28889093
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27601146
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24610578
112Phototransduction_Homo sapiens_hsa047440.24518388
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24289665
114Wnt signaling pathway_Homo sapiens_hsa043100.24223163
115MicroRNAs in cancer_Homo sapiens_hsa052060.22083462
116Viral carcinogenesis_Homo sapiens_hsa052030.22021867
117Vibrio cholerae infection_Homo sapiens_hsa051100.21744994
118Bladder cancer_Homo sapiens_hsa052190.20005074
119Epstein-Barr virus infection_Homo sapiens_hsa051690.19884168
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17089193
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14397347
122Ether lipid metabolism_Homo sapiens_hsa005650.12950361
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.11179262
124Arachidonic acid metabolism_Homo sapiens_hsa005900.04948942
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.01542441
126Cardiac muscle contraction_Homo sapiens_hsa042600.00467097
127Mineral absorption_Homo sapiens_hsa04978-0.1257401
128Regulation of autophagy_Homo sapiens_hsa04140-0.1157360
129AMPK signaling pathway_Homo sapiens_hsa04152-0.1114227
130Purine metabolism_Homo sapiens_hsa00230-0.1105576
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0946099
132Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0893910
133Insulin resistance_Homo sapiens_hsa04931-0.0878636
134Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0697547
135Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0308612
136Glucagon signaling pathway_Homo sapiens_hsa04922-0.0198084
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0113542
138Pyrimidine metabolism_Homo sapiens_hsa00240-0.0018512

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