GLP1R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)8.31039982
2endocrine pancreas development (GO:0031018)7.60684527
3regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022357.01804621
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.77869390
5COPII vesicle coating (GO:0048208)6.76915543
6peptide hormone processing (GO:0016486)6.68416849
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.56308790
8exocrine pancreas development (GO:0031017)6.50835169
9regulation of type B pancreatic cell apoptotic process (GO:2000674)6.26421876
10activation of signaling protein activity involved in unfolded protein response (GO:0006987)6.04650028
11type B pancreatic cell development (GO:0003323)6.02712214
12protein retention in ER lumen (GO:0006621)6.01447506
13glandular epithelial cell differentiation (GO:0002067)5.82772422
14positive regulation of nuclease activity (GO:0032075)5.76957380
15glandular epithelial cell development (GO:0002068)5.48777626
16insulin secretion (GO:0030073)5.36686579
17regulation of nuclease activity (GO:0032069)5.25563049
18vesicle coating (GO:0006901)5.16812893
19cellular response to vitamin D (GO:0071305)5.02783350
20endoplasmic reticulum unfolded protein response (GO:0030968)4.98965807
21positive regulation of insulin secretion (GO:0032024)4.90645417
22cellular response to unfolded protein (GO:0034620)4.85153767
23sequestering of metal ion (GO:0051238)4.77352699
24nitric oxide mediated signal transduction (GO:0007263)4.70935030
25signal peptide processing (GO:0006465)4.69818543
26ER-nucleus signaling pathway (GO:0006984)4.69702633
27cellular response to topologically incorrect protein (GO:0035967)4.68317276
28negative regulation of hormone biosynthetic process (GO:0032353)4.58090875
29tachykinin receptor signaling pathway (GO:0007217)4.55467104
30negative regulation of glycoprotein biosynthetic process (GO:0010561)4.47169053
31ER overload response (GO:0006983)4.43430462
32* regulation of insulin secretion (GO:0050796)4.43407365
33columnar/cuboidal epithelial cell development (GO:0002066)4.43040493
34detection of calcium ion (GO:0005513)4.30727232
35ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.27956918
36embryonic retina morphogenesis in camera-type eye (GO:0060059)4.26168480
37L-alpha-amino acid transmembrane transport (GO:1902475)4.16694436
38intra-Golgi vesicle-mediated transport (GO:0006891)4.10232447
39* regulation of peptide hormone secretion (GO:0090276)4.03701930
40negative regulation of insulin secretion (GO:0046676)3.99659725
41positive regulation of peptide hormone secretion (GO:0090277)3.97912066
42response to endoplasmic reticulum stress (GO:0034976)3.97047425
43* regulation of peptide secretion (GO:0002791)3.96718444
44response to hepatocyte growth factor (GO:0035728)3.91231693
45cellular response to hepatocyte growth factor stimulus (GO:0035729)3.91231693
46peptide hormone secretion (GO:0030072)3.91087394
47negative regulation of hormone metabolic process (GO:0032351)3.89681158
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.88936904
49peptide secretion (GO:0002790)3.85710695
50positive regulation of peptide secretion (GO:0002793)3.85656174
51protein localization to cilium (GO:0061512)3.82416295
52toxin metabolic process (GO:0009404)3.81863569
53protein N-linked glycosylation via asparagine (GO:0018279)3.79877267
54peptidyl-asparagine modification (GO:0018196)3.77900921
55macroautophagy (GO:0016236)3.73471367
56response to unfolded protein (GO:0006986)3.70923628
57negative regulation of norepinephrine secretion (GO:0010700)3.68142930
58protein localization to Golgi apparatus (GO:0034067)3.66263636
59protein targeting to Golgi (GO:0000042)3.64681887
60ER to Golgi vesicle-mediated transport (GO:0006888)3.63341661
614-hydroxyproline metabolic process (GO:0019471)3.59956177
62response to topologically incorrect protein (GO:0035966)3.58929320
63Golgi organization (GO:0007030)3.57791417
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.56646273
65negative regulation of catecholamine secretion (GO:0033604)3.56076993
66chemosensory behavior (GO:0007635)3.49152859
67response to hexose (GO:0009746)3.47833005
68negative regulation of peptide hormone secretion (GO:0090278)3.47665244
69cellular response to vitamin (GO:0071295)3.46286838
70protein N-linked glycosylation (GO:0006487)3.46246141
71response to glucose (GO:0009749)3.43950054
72* regulation of hormone secretion (GO:0046883)3.43900905
73intestinal epithelial cell development (GO:0060576)3.41181783
74nucleoside diphosphate catabolic process (GO:0009134)3.40356218
75negative regulation of glycogen metabolic process (GO:0070874)3.39032932
76negative regulation of peptide secretion (GO:0002792)3.35445371
77negative regulation of glycoprotein metabolic process (GO:1903019)3.35176631
78inner ear receptor cell development (GO:0060119)3.34589617
79positive regulation of glycolytic process (GO:0045821)3.34272240
80cerebellar Purkinje cell layer development (GO:0021680)3.32978445
81astrocyte differentiation (GO:0048708)3.31178051
82response to monosaccharide (GO:0034284)3.30694509
83intestinal absorption (GO:0050892)3.28958016
84* regulation of peptide transport (GO:0090087)3.27543072
85intestinal cholesterol absorption (GO:0030299)3.27485199
86negative regulation of bone resorption (GO:0045779)3.26807749
87positive regulation of macroautophagy (GO:0016239)3.26195705
88epithelial cell fate commitment (GO:0072148)3.24691322
89cellular zinc ion homeostasis (GO:0006882)3.24626967
90establishment of protein localization to Golgi (GO:0072600)3.24404861
91retrograde transport, vesicle recycling within Golgi (GO:0000301)3.19042861
92UDP-N-acetylglucosamine metabolic process (GO:0006047)3.17445770
93negative regulation of gluconeogenesis (GO:0045721)3.14796289
94tricarboxylic acid metabolic process (GO:0072350)3.12366668
95kidney morphogenesis (GO:0060993)3.10726937
96positive regulation of hormone secretion (GO:0046887)3.10115347
97response to ischemia (GO:0002931)3.09164379
98nodal signaling pathway (GO:0038092)3.08494212
99peptide transport (GO:0015833)3.06214235
100fatty acid homeostasis (GO:0055089)3.04838607
101membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.02427715
102regulation of calcium ion-dependent exocytosis (GO:0017158)3.02252688
103carbohydrate homeostasis (GO:0033500)3.01490226
104glucose homeostasis (GO:0042593)3.01490226
105Golgi vesicle transport (GO:0048193)3.00973416
106hormone secretion (GO:0046879)2.99986031
107negative regulation of translation, ncRNA-mediated (GO:0040033)2.98219978
108regulation of translation, ncRNA-mediated (GO:0045974)2.98219978
109negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.98219978
110response to carbohydrate (GO:0009743)2.94248695
111growth hormone secretion (GO:0030252)2.92024600
112regulation of glucocorticoid secretion (GO:2000849)2.91709107
113genitalia morphogenesis (GO:0035112)2.88762523
114response to lipoprotein particle (GO:0055094)2.88293289
115calcium ion import (GO:0070509)2.87964128
116regulation of Golgi to plasma membrane protein transport (GO:0042996)2.87552341
117respiratory chain complex IV assembly (GO:0008535)2.86994726
118glycerophospholipid catabolic process (GO:0046475)2.85806916
119regulation of hexokinase activity (GO:1903299)2.84714324
120regulation of glucokinase activity (GO:0033131)2.84714324
121lactate metabolic process (GO:0006089)2.83681745
122negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.80831486
123cochlea development (GO:0090102)2.78723286
124positive regulation of response to extracellular stimulus (GO:0032106)2.75584050
125positive regulation of response to nutrient levels (GO:0032109)2.75584050
126startle response (GO:0001964)2.72605694
127regulation of energy homeostasis (GO:2000505)2.71909470
128intraciliary transport (GO:0042073)2.71793599
129regulation of male gonad development (GO:2000018)2.71380487
130phasic smooth muscle contraction (GO:0014821)2.67730775
131mesenchymal cell differentiation involved in kidney development (GO:0072161)2.67271877
132mesenchymal cell differentiation involved in renal system development (GO:2001012)2.67271877
133regulation of timing of cell differentiation (GO:0048505)2.65887539
134regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65874612
135positive regulation of protein autophosphorylation (GO:0031954)2.63445011
136regulation of telomere maintenance (GO:0032204)2.62659207
137artery smooth muscle contraction (GO:0014824)2.61241542
138adrenergic receptor signaling pathway (GO:0071875)2.61235140
139cell differentiation involved in metanephros development (GO:0072202)2.59438797
140response to pheromone (GO:0019236)2.58733658
141negative regulation of neurological system process (GO:0031645)2.57203037
142retinal ganglion cell axon guidance (GO:0031290)2.56078714
143regulation of neuron migration (GO:2001222)2.55438128
144regulation of feeding behavior (GO:0060259)2.55082199
145dendritic spine morphogenesis (GO:0060997)2.55078504
146positive regulation of calcium ion import (GO:0090280)2.51369582
147negative regulation of dendrite development (GO:2000171)2.47301964
148regulation of glycolytic process (GO:0006110)2.45041865
149pancreas development (GO:0031016)2.44868472
150detection of light stimulus involved in sensory perception (GO:0050962)2.44648383
151detection of light stimulus involved in visual perception (GO:0050908)2.44648383
152adaptation of signaling pathway (GO:0023058)2.44255773
153protein K6-linked ubiquitination (GO:0085020)2.43909193
154adult feeding behavior (GO:0008343)2.43412917
155innervation (GO:0060384)2.43211341
156cellular ketone body metabolic process (GO:0046950)2.43114830
157regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.42396955
158positive regulation of ATP catabolic process (GO:1903291)2.41960477
159positive regulation of ATPase activity (GO:0032781)2.41960477
160regulation of acrosome reaction (GO:0060046)2.41362055
161cytochrome complex assembly (GO:0017004)2.40519802
162positive regulation of respiratory burst (GO:0060267)2.40242568
163righting reflex (GO:0060013)2.36570708
164COPI coating of Golgi vesicle (GO:0048205)10.8624786
165Golgi transport vesicle coating (GO:0048200)10.8624786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.99115095
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.89292128
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.00414604
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.74673878
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68948497
6IGF1R_20145208_ChIP-Seq_DFB_Human2.52088913
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42288834
8P300_19829295_ChIP-Seq_ESCs_Human2.22981400
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18467322
10FUS_26573619_Chip-Seq_HEK293_Human2.10993143
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.09273889
12ZNF274_21170338_ChIP-Seq_K562_Hela2.00768566
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.0394410
14VDR_22108803_ChIP-Seq_LS180_Human1.97372569
15EWS_26573619_Chip-Seq_HEK293_Human1.96159731
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.92966866
17TAF15_26573619_Chip-Seq_HEK293_Human1.91090141
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.90550049
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90346758
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90172125
21REST_21632747_ChIP-Seq_MESCs_Mouse1.88680245
22CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.85686491
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84208583
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.83265167
25NR3C1_23031785_ChIP-Seq_PC12_Mouse1.82430007
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81793887
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80298558
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76929282
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.76164354
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75365058
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74797532
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62981019
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.61218437
34AR_25329375_ChIP-Seq_VCAP_Human1.60291268
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60163775
36FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.59333378
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58780475
38CBP_20019798_ChIP-Seq_JUKART_Human1.58466930
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58466930
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56767524
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56047444
42* BCAT_22108803_ChIP-Seq_LS180_Human1.53551961
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52072099
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.50345322
45OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47463383
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.46348904
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45885462
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45589938
49TFEB_21752829_ChIP-Seq_HELA_Human1.44874134
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.44196844
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43439356
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42672936
53RNF2_27304074_Chip-Seq_NSC_Mouse1.42541223
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40978913
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40714822
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40452550
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39884059
58* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.38677538
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.38613106
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.37053526
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36532906
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34729377
63* TCF4_22108803_ChIP-Seq_LS180_Human1.34463245
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34355209
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33913443
66RUNX2_22187159_ChIP-Seq_PCA_Human1.33060123
67* GATA1_19941826_ChIP-Seq_K562_Human1.32648256
68REST_19997604_ChIP-ChIP_NEURONS_Mouse1.31992912
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.31789762
70* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31778747
71HTT_18923047_ChIP-ChIP_STHdh_Human1.31749798
72ER_23166858_ChIP-Seq_MCF-7_Human1.30760056
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29995604
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28972503
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28969824
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28797460
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.27762494
78NANOG_19829295_ChIP-Seq_ESCs_Human1.27670911
79SOX2_19829295_ChIP-Seq_ESCs_Human1.27670911
80FOXA1_25552417_ChIP-Seq_VCAP_Human1.27097624
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26541442
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26453729
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25215519
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.23560614
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23287182
86ERG_20517297_ChIP-Seq_VCAP_Human1.22797668
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21030108
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20985370
89STAT3_23295773_ChIP-Seq_U87_Human1.20830274
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20553990
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19371516
92FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19167990
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19035254
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18342833
95CDX2_22108803_ChIP-Seq_LS180_Human1.17588237
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.16840639
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.16791146
98* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15380440
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15255453
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14556681
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.14251463
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14100275
103RARB_27405468_Chip-Seq_BRAIN_Mouse1.14078621
104P53_22387025_ChIP-Seq_ESCs_Mouse1.14053604
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13543810
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.11084586
107* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10539824
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.10422641
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10224997
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10102151
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10102151
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09362551
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08584638
114CLOCK_20551151_ChIP-Seq_293T_Human1.08538241
115* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08258008
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.07735741
117FOXA2_19822575_ChIP-Seq_HepG2_Human1.06122378
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05883864
119SMAD4_21741376_ChIP-Seq_HESCs_Human1.05529240
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05360398
121TP53_18474530_ChIP-ChIP_U2OS_Human1.03772902
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03207097
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03105581
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03075860
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02318194
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00242756
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96741523
128EZH2_22144423_ChIP-Seq_EOC_Human0.95858907
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.95770486
130CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95686102
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95238455
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94841389
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92976862
134TP53_22573176_ChIP-Seq_HFKS_Human0.91454197
135GATA3_27048872_Chip-Seq_THYMUS_Human0.91416522
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89728260
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.88094306
138GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87403400
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86826877
140SPI1_23127762_ChIP-Seq_K562_Human0.86657979
141DROSHA_22980978_ChIP-Seq_HELA_Human0.86095567
142AR_19668381_ChIP-Seq_PC3_Human0.85789172
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.85070991
144EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84140475
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83619378
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82898157
147* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82259759
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81625871
149ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80969015
150* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80617628
151TBX3_20139965_ChIP-Seq_MESCs_Mouse0.79334337
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79191732
153CREB1_26743006_Chip-Seq_LNCaP_Human0.79189159
154MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78804368
155* FLI1_21867929_ChIP-Seq_TH2_Mouse0.78528928
156ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78490446
157* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78007614
158* TDRD3_21172665_ChIP-Seq_MCF-7_Human0.77624394
159STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77577426
160GATA3_24758297_ChIP-Seq_MCF-7_Human0.77266359
161FOXH1_21741376_ChIP-Seq_ESCs_Human0.76158378
162SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76113518
163PPARA_22158963_ChIP-Seq_LIVER_Mouse0.75906309
164SMAD4_21799915_ChIP-Seq_A2780_Human0.75309775
165GBX2_23144817_ChIP-Seq_PC3_Human0.74005954
166PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73961740
167GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72856653
168TBX20_22328084_ChIP-Seq_HEART_Mouse0.70996084
169TBX20_22080862_ChIP-Seq_HEART_Mouse0.70996084
170* TET1_21490601_ChIP-Seq_MESCs_Mouse0.70905176
171GATA3_26560356_Chip-Seq_TH2_Human0.70752738
172CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70240315
173TCF4_23295773_ChIP-Seq_U87_Human0.70100278
174FOXO3_23340844_ChIP-Seq_DLD1_Human0.69800287
175SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69674472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.29744877
2MP0002877_abnormal_melanocyte_morpholog5.58045479
3MP0009780_abnormal_chondrocyte_physiolo4.79252199
4* MP0002693_abnormal_pancreas_physiology4.53645277
5MP0002909_abnormal_adrenal_gland4.40126214
6MP0004043_abnormal_pH_regulation4.33891820
7MP0001944_abnormal_pancreas_morphology4.04554809
8MP0003195_calcinosis3.87665011
9MP0000678_abnormal_parathyroid_gland3.58312683
10MP0005379_endocrine/exocrine_gland_phen3.30068819
11MP0000013_abnormal_adipose_tissue3.14330691
12MP0005220_abnormal_exocrine_pancreas2.94700438
13MP0010386_abnormal_urinary_bladder2.72443243
14MP0003183_abnormal_peptide_metabolism2.70458563
15MP0008877_abnormal_DNA_methylation2.46473793
16MP0002822_catalepsy2.43752950
17* MP0002078_abnormal_glucose_homeostasis2.42996177
18MP0003300_gastrointestinal_ulcer2.15392234
19MP0004264_abnormal_extraembryonic_tissu2.14073700
20MP0006276_abnormal_autonomic_nervous2.13871187
21MP0005646_abnormal_pituitary_gland2.06200876
22MP0003123_paternal_imprinting1.98802028
23MP0002837_dystrophic_cardiac_calcinosis1.98621469
24MP0000462_abnormal_digestive_system1.97197740
25MP0004510_myositis1.89321055
26MP0002234_abnormal_pharynx_morphology1.87362005
27MP0003172_abnormal_lysosome_physiology1.85980208
28MP0002928_abnormal_bile_duct1.84557892
29MP0002896_abnormal_bone_mineralization1.76528603
30MP0006072_abnormal_retinal_apoptosis1.66973701
31MP0009046_muscle_twitch1.66517820
32MP0002102_abnormal_ear_morphology1.61502801
33MP0000003_abnormal_adipose_tissue1.60082346
34MP0003121_genomic_imprinting1.59523793
35MP0003122_maternal_imprinting1.59371113
36MP0008961_abnormal_basal_metabolism1.55889373
37MP0005551_abnormal_eye_electrophysiolog1.55043452
38MP0001765_abnormal_ion_homeostasis1.52039906
39MP0002938_white_spotting1.51376430
40MP0002090_abnormal_vision1.49492714
41MP0001986_abnormal_taste_sensitivity1.48360280
42MP0004215_abnormal_myocardial_fiber1.45815531
43* MP0003953_abnormal_hormone_level1.41568181
44MP0000613_abnormal_salivary_gland1.40550967
45MP0004270_analgesia1.39602653
46MP0002638_abnormal_pupillary_reflex1.38863994
47MP0003868_abnormal_feces_composition1.38584974
48MP0005058_abnormal_lysosome_morphology1.32004132
49MP0003252_abnormal_bile_duct1.31447026
50MP0009643_abnormal_urine_homeostasis1.29050866
51MP0008004_abnormal_stomach_pH1.27869203
52MP0001984_abnormal_olfaction1.24884967
53MP0000566_synostosis1.23667888
54MP0005365_abnormal_bile_salt1.20523773
55MP0005535_abnormal_body_temperature1.17559268
56MP0005187_abnormal_penis_morphology1.16909759
57MP0002557_abnormal_social/conspecific_i1.12395339
58MP0003119_abnormal_digestive_system1.12267173
59MP0002138_abnormal_hepatobiliary_system1.10131516
60MP0004885_abnormal_endolymph1.09397278
61MP0005645_abnormal_hypothalamus_physiol1.08034467
62MP0003011_delayed_dark_adaptation1.05824985
63MP0003943_abnormal_hepatobiliary_system1.05413408
64MP0005310_abnormal_salivary_gland1.05221374
65MP0001666_abnormal_nutrient_absorption1.01279270
66MP0001661_extended_life_span1.01212801
67MP0002272_abnormal_nervous_system1.00904027
68MP0002751_abnormal_autonomic_nervous1.00853316
69MP0003959_abnormal_lean_body1.00403616
70MP0003045_fibrosis1.00169427
71MP0002876_abnormal_thyroid_physiology0.99228664
72MP0006054_spinal_hemorrhage0.98667163
73MP0001270_distended_abdomen0.97880858
74MP0000631_abnormal_neuroendocrine_gland0.97266605
75MP0005083_abnormal_biliary_tract0.96380907
76MP0005257_abnormal_intraocular_pressure0.96206180
77MP0005367_renal/urinary_system_phenotyp0.96162467
78MP0000516_abnormal_urinary_system0.96162467
79MP0001299_abnormal_eye_distance/0.95557957
80MP0009745_abnormal_behavioral_response0.95148848
81MP0000372_irregular_coat_pigmentation0.94845850
82MP0001968_abnormal_touch/_nociception0.92533597
83MP0003866_abnormal_defecation0.92359884
84MP0009672_abnormal_birth_weight0.91289594
85MP0004133_heterotaxia0.90583437
86MP0005448_abnormal_energy_balance0.89783865
87MP0004084_abnormal_cardiac_muscle0.89145934
88MP0000639_abnormal_adrenal_gland0.87465749
89MP0002572_abnormal_emotion/affect_behav0.86905378
90MP0001756_abnormal_urination0.84917049
91MP0000569_abnormal_digit_pigmentation0.84640125
92MP0003137_abnormal_impulse_conducting0.84577558
93MP0003635_abnormal_synaptic_transmissio0.83859321
94MP0000230_abnormal_systemic_arterial0.83610436
95MP0005386_behavior/neurological_phenoty0.83040109
96MP0004924_abnormal_behavior0.83040109
97MP0002184_abnormal_innervation0.82393103
98MP0004134_abnormal_chest_morphology0.82320817
99MP0005636_abnormal_mineral_homeostasis0.82167516
100MP0000778_abnormal_nervous_system0.81580138
101MP0002064_seizures0.79780580
102MP0004142_abnormal_muscle_tone0.77867902
103MP0000681_abnormal_thyroid_gland0.76041578
104MP0001188_hyperpigmentation0.73853649
105MP0002163_abnormal_gland_morphology0.72229746
106MP0004145_abnormal_muscle_electrophysio0.72213188
107MP0000647_abnormal_sebaceous_gland0.71976089
108MP0003567_abnormal_fetal_cardiomyocyte0.71423439
109MP0005375_adipose_tissue_phenotype0.71419913
110MP0001485_abnormal_pinna_reflex0.71156821
111MP0002067_abnormal_sensory_capabilities0.70780891
112MP0005248_abnormal_Harderian_gland0.70432742
113MP0005395_other_phenotype0.70235911
114MP0002736_abnormal_nociception_after0.68657773
115MP0002063_abnormal_learning/memory/cond0.68647163
116MP0003880_abnormal_central_pattern0.67912937
117MP0009703_decreased_birth_body0.67822632
118MP0002139_abnormal_hepatobiliary_system0.67432922
119MP0002233_abnormal_nose_morphology0.67369359
120MP0003938_abnormal_ear_development0.66550136
121MP0001501_abnormal_sleep_pattern0.66177910
122MP0001486_abnormal_startle_reflex0.65525611
123MP0005076_abnormal_cell_differentiation0.65251306
124MP0009840_abnormal_foam_cell0.65027978
125MP0003942_abnormal_urinary_system0.64825816
126MP0002733_abnormal_thermal_nociception0.64394815
127MP0002118_abnormal_lipid_homeostasis0.63923179
128MP0004036_abnormal_muscle_relaxation0.62516321
129MP0002168_other_aberrant_phenotype0.60583874
130MP0001502_abnormal_circadian_rhythm0.57068690
131MP0005253_abnormal_eye_physiology0.55524555
132MP0005334_abnormal_fat_pad0.55199248
133MP0003890_abnormal_embryonic-extraembry0.55183924
134MP0003879_abnormal_hair_cell0.53930828
135* MP0009642_abnormal_blood_homeostasis0.52660254
136MP0003795_abnormal_bone_structure0.52386336
137MP0001346_abnormal_lacrimal_gland0.51521356
138MP0004185_abnormal_adipocyte_glucose0.51420651
139MP0000955_abnormal_spinal_cord0.50104110
140MP0005670_abnormal_white_adipose0.48501688
141MP0001849_ear_inflammation0.48185989
142MP0003787_abnormal_imprinting0.48106013
143MP0002069_abnormal_eating/drinking_beha0.47807794
144MP0000428_abnormal_craniofacial_morphol0.47396132
145MP0005452_abnormal_adipose_tissue0.46505633
146MP0001731_abnormal_postnatal_growth0.46066088
147MP0004085_abnormal_heartbeat0.45862370
148MP0000538_abnormal_urinary_bladder0.45371140
149MP0000470_abnormal_stomach_morphology0.43903056
150MP0000163_abnormal_cartilage_morphology0.43348538
151MP0002269_muscular_atrophy0.42786227
152MP0002229_neurodegeneration0.42624246
153MP0002734_abnormal_mechanical_nocicepti0.40213027

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.92034658
2Hypoglycemic seizures (HP:0002173)8.17614956
3Symptomatic seizures (HP:0011145)7.41731717
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.14093809
5Hypoglycemic coma (HP:0001325)7.07026876
6Insulin-resistant diabetes mellitus (HP:0000831)5.91131875
7Pancreatic islet-cell hyperplasia (HP:0004510)5.24658041
8Abnormality of the pancreatic islet cells (HP:0006476)5.14800237
9Abnormality of endocrine pancreas physiology (HP:0012093)5.14800237
10Hyperglycemia (HP:0003074)5.13327918
11Ketoacidosis (HP:0001993)4.79333378
12Large for gestational age (HP:0001520)4.76970616
13Decreased circulating renin level (HP:0003351)4.41675207
14Abnormal pancreas size (HP:0012094)4.37542852
15Late onset (HP:0003584)4.35844439
16Abnormality of calcium-phosphate metabolism (HP:0100530)4.26643447
17Urinary glycosaminoglycan excretion (HP:0003541)4.15961453
18Mucopolysacchariduria (HP:0008155)4.15961453
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.82907043
20Abnormality of polysaccharide metabolism (HP:0011012)3.82907043
21Abnormality of glycosaminoglycan metabolism (HP:0004371)3.82907043
22Dysostosis multiplex (HP:0000943)3.67649950
23Hypokalemia (HP:0002900)3.66070713
24Hypomagnesemia (HP:0002917)3.51984372
25Double outlet right ventricle (HP:0001719)3.48308542
26Congenital malformation of the right heart (HP:0011723)3.48308542
27Insulin resistance (HP:0000855)3.46092120
28Generalized aminoaciduria (HP:0002909)3.43083286
29Abnormality of renin-angiotensin system (HP:0000847)3.16911972
30Osteomalacia (HP:0002749)3.16139844
31Agitation (HP:0000713)3.07411890
32Prominent metopic ridge (HP:0005487)3.00064797
33Abnormality of the intrinsic pathway (HP:0010989)2.97498388
34Papilledema (HP:0001085)2.96747134
35Intestinal atresia (HP:0011100)2.91508791
36Conjugated hyperbilirubinemia (HP:0002908)2.90456428
37Hyperparathyroidism (HP:0000843)2.88742256
38Abnormality of potassium homeostasis (HP:0011042)2.78370302
39Ketosis (HP:0001946)2.71490525
40Thoracolumbar scoliosis (HP:0002944)2.67312943
41Medial flaring of the eyebrow (HP:0010747)2.65996575
42Unilateral renal agenesis (HP:0000122)2.65442634
43Abnormality of magnesium homeostasis (HP:0004921)2.59518434
44Abnormality of the metopic suture (HP:0005556)2.58694784
45Increased circulating renin level (HP:0000848)2.57269699
46EEG with generalized epileptiform discharges (HP:0011198)2.56147027
47Hypsarrhythmia (HP:0002521)2.54454351
48Hyperactive renin-angiotensin system (HP:0000841)2.50599759
49Retinal atrophy (HP:0001105)2.50240732
50Tetany (HP:0001281)2.49265006
51Gait imbalance (HP:0002141)2.45486631
52Epileptiform EEG discharges (HP:0011182)2.43842889
53Limb hypertonia (HP:0002509)2.42253135
54Genital tract atresia (HP:0001827)2.38389604
55Congenital primary aphakia (HP:0007707)2.36048816
56Exocrine pancreatic insufficiency (HP:0001738)2.31388935
57Type I diabetes mellitus (HP:0100651)2.31008776
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30265856
59Abdominal distention (HP:0003270)2.30183490
60Hyperkalemia (HP:0002153)2.27876959
61Hyperventilation (HP:0002883)2.23276494
62Hypothermia (HP:0002045)2.23171385
63Vaginal atresia (HP:0000148)2.23012943
64Visual hallucinations (HP:0002367)2.22014546
65Chronic bronchitis (HP:0004469)2.18806248
66Nephronophthisis (HP:0000090)2.17978147
67Protuberant abdomen (HP:0001538)2.16826080
68Hypophosphatemia (HP:0002148)2.15938912
69Gout (HP:0001997)2.13356962
70Dysautonomia (HP:0002459)2.12773656
71Hyperphosphatemia (HP:0002905)2.07697825
72Hyperphosphaturia (HP:0003109)2.07631436
73Villous atrophy (HP:0011473)2.05745509
74Abnormality of small intestinal villus morphology (HP:0011472)2.05745509
75Congenital stationary night blindness (HP:0007642)2.02170039
76Aqueductal stenosis (HP:0002410)2.01759780
77Congenital glaucoma (HP:0001087)2.01620543
78Abnormality of the labia minora (HP:0012880)2.01588584
79Polyuria (HP:0000103)2.00529798
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00322331
81Hepatic necrosis (HP:0002605)1.99669073
82Hypotension (HP:0002615)1.99460174
83Progressive neurologic deterioration (HP:0002344)1.99105027
84Skin nodule (HP:0200036)1.98679692
85Severe short stature (HP:0003510)1.98574387
86Pheochromocytoma (HP:0002666)1.98367746
87Abnormality of the common coagulation pathway (HP:0010990)1.98347369
88Restlessness (HP:0000711)1.98336501
89Pancreatic fibrosis (HP:0100732)1.96532936
90Nephrogenic diabetes insipidus (HP:0009806)1.95405127
91Missing ribs (HP:0000921)1.95267091
92Tachypnea (HP:0002789)1.93747511
93Hypokalemic alkalosis (HP:0001949)1.92047369
94Abnormality of the renal medulla (HP:0100957)1.90251886
95Abnormality of abdominal situs (HP:0011620)1.90105996
96Abdominal situs inversus (HP:0003363)1.90105996
97Enlarged penis (HP:0000040)1.88370580
98Abnormality of purine metabolism (HP:0004352)1.88246705
99Labial hypoplasia (HP:0000066)1.87787520
100Hypogonadotrophic hypogonadism (HP:0000044)1.87649186
101Downturned corners of mouth (HP:0002714)1.86650310
102Hypercortisolism (HP:0001578)1.86508157
103Abnormality of the renal cortex (HP:0011035)1.85625591
104Oligodactyly (hands) (HP:0001180)1.81562644
105Pancreatic cysts (HP:0001737)1.81305466
106Gastrointestinal atresia (HP:0002589)1.80946056
107Macroorchidism (HP:0000053)1.80171563
108Glucose intolerance (HP:0000833)1.79521842
109Cortical visual impairment (HP:0100704)1.79088242
110Poor coordination (HP:0002370)1.78993938
111Volvulus (HP:0002580)1.78312292
112True hermaphroditism (HP:0010459)1.77973706
113Elevated alkaline phosphatase (HP:0003155)1.75668968
114Irregular vertebral endplates (HP:0003301)1.75164685
115Abnormality of midbrain morphology (HP:0002418)1.74809851
116Molar tooth sign on MRI (HP:0002419)1.74809851
117Muscular hypotonia of the trunk (HP:0008936)1.74716873
118Truncal obesity (HP:0001956)1.74602851
119Decreased subcutaneous fat (HP:0001002)1.73504094
120Abnormality of chloride homeostasis (HP:0011422)1.73116960
121Metaphyseal irregularity (HP:0003025)1.72927259
122Global brain atrophy (HP:0002283)1.71722934
123Sex reversal (HP:0012245)1.71430476
124Abnormal sex determination (HP:0012244)1.71430476
125Widely spaced teeth (HP:0000687)1.70611441
126Abnormality of macular pigmentation (HP:0008002)1.69819580
127Oligomenorrhea (HP:0000876)1.69199272
128Increased cerebral lipofuscin (HP:0011813)1.67379300
129Febrile seizures (HP:0002373)1.67004933
130Abnormal urine phosphate concentration (HP:0012599)1.66818319
131Abnormality of alkaline phosphatase activity (HP:0004379)1.66649381
132Acute hepatic failure (HP:0006554)1.64554167
133Drooling (HP:0002307)1.64413985
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.63201914
135Hypoplasia of the fovea (HP:0007750)1.63201914
136Syncope (HP:0001279)1.62381725
137Menstrual irregularities (HP:0000858)1.62270674
138Polydipsia (HP:0001959)1.62117756
139Abnormal drinking behavior (HP:0030082)1.62117756
140Abnormal protein glycosylation (HP:0012346)1.61489457
141Abnormal glycosylation (HP:0012345)1.61489457
142Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61489457
143Abnormal protein N-linked glycosylation (HP:0012347)1.61489457
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.61454030
145Thin bony cortex (HP:0002753)1.61252983
146Hypoplastic female external genitalia (HP:0012815)1.60668455
147Neuroendocrine neoplasm (HP:0100634)1.60478336
148Abnormal biliary tract morphology (HP:0012440)1.60472275
149Type II diabetes mellitus (HP:0005978)1.60234698
150Tongue fasciculations (HP:0001308)1.58251907
151Hypoplastic labia majora (HP:0000059)1.57127060
152Left ventricular hypertrophy (HP:0001712)1.56076423
153Attenuation of retinal blood vessels (HP:0007843)1.54733586
154Fair hair (HP:0002286)1.54314144
155Abnormal urine output (HP:0012590)1.54228013
156Male pseudohermaphroditism (HP:0000037)1.49714839
157Maternal diabetes (HP:0009800)1.49292441
158Decreased central vision (HP:0007663)1.48873677
159Broad-based gait (HP:0002136)1.48138646
160Broad foot (HP:0001769)1.48068616
161Calf muscle hypertrophy (HP:0008981)1.47798508
162Renal cortical cysts (HP:0000803)1.47480669
163Decreased testicular size (HP:0008734)1.44401272
164Excessive salivation (HP:0003781)1.42563615
165Blue irides (HP:0000635)1.42239594
166Abnormality of renal excretion (HP:0011036)1.42172140
167Short foot (HP:0001773)1.41563741
168Gaze-evoked nystagmus (HP:0000640)1.40503993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.37155255
2PASK6.69611695
3TAOK34.13784337
4MAPK153.50249444
5HIPK23.21235027
6PRKD33.05147807
7MAP4K22.91968371
8FLT32.74919040
9ERN12.71154930
10TIE12.61894127
11BMPR1B2.60757881
12TNIK2.37190212
13DAPK22.30906503
14MAP3K22.30696010
15NTRK12.22866559
16SCYL22.20521503
17FGFR22.18753953
18CASK2.15760739
19FRK2.14934310
20MAP3K42.05780968
21PDGFRA1.94393302
22GRK11.87479771
23MAP3K11.78984050
24PNCK1.77203076
25TRPM71.73710902
26ACVR1B1.73531842
27STK391.56754572
28NTRK31.55148557
29CAMKK21.53740290
30TRIB31.49324512
31UHMK11.49042927
32WNK41.43090955
33MET1.38765214
34PRKCH1.38463759
35CDK31.38368501
36BRSK21.37019272
37PHKG21.35583120
38PHKG11.35583120
39PTK21.34771763
40MARK11.33675347
41CDC42BPA1.32364549
42EPHA31.31918105
43MKNK21.29027375
44CAMK1D1.27582424
45TGFBR11.22770763
46PTK61.21404457
47MAPK131.18941410
48SIK11.15772693
49STK38L1.14777978
50CSNK1G11.14478546
51MST41.11677458
52MAP2K71.09771853
53IRAK31.08468361
54AKT31.03494595
55LMTK21.01756680
56PRKD20.99227455
57OXSR10.97734320
58STK30.94752653
59TRIM280.93204489
60ERBB30.91034396
61DYRK1B0.90731317
62PAK30.88782230
63EIF2AK30.88379515
64IRAK10.88356610
65PRKAA20.84428414
66JAK20.80881876
67ADRBK20.80033577
68NUAK10.78726268
69MAP2K20.78331653
70PKN10.78311246
71MAP2K60.78143762
72BCKDK0.76683431
73CSNK1A1L0.76673687
74MAP3K70.75332642
75YES10.71925747
76TSSK60.71509369
77JAK30.70415353
78CSNK1G20.69759886
79RET0.68364966
80STK110.67454547
81PLK30.65989212
82PRKAA10.60291278
83ITK0.60151623
84JAK10.59825385
85WNK10.59768464
86PLK20.59186477
87FER0.57698609
88STK240.57164235
89CSNK1G30.56707650
90PRKCE0.56068565
91MKNK10.55781134
92DYRK30.55257994
93LATS10.54594304
94PDGFRB0.53593588
95ZAP700.53047566
96STK160.52658902
97MAP2K40.52639424
98FGFR40.52151363
99IRAK20.51171059
100MARK20.51109735
101ROCK10.49784314
102CAMKK10.49261901
103ATM0.48494248
104VRK10.47908801
105PINK10.47507023
106ALK0.46769829
107PRKACG0.46735385
108DMPK0.46527198
109BRD40.46478486
110GSK3A0.46087945
111PRKD10.45256609
112BRSK10.44878525
113MTOR0.44551287
114CAMK2A0.44148859
115CAMK2D0.44092973
116NTRK20.42191383
117WNK30.40192073
118PRKG10.39895622
119EPHB10.39213132
120IGF1R0.39186357
121PRKCI0.38512636
122BRAF0.38069212
123ZAK0.38025237
124DYRK20.38004151
125CDK50.37992473
126CAMK10.37065533
127WEE10.36658289
128MELK0.36525377
129ADRBK10.35958460
130DAPK30.35562118
131CAMK1G0.34245539
132FGFR30.33607669
133CSNK1A10.32204564
134PRKDC0.31679861
135PRKACA0.31524775
136RPS6KA20.30632008
137BCR0.30167597
138KSR20.29067692
139CAMK2B0.28841294
140MAPK140.27886967
141RPS6KB10.27463314
142TESK10.25481419
143MAP3K100.25312243
144GRK50.23254237
145MAP2K10.22684600
146MAP3K30.21980804
147RPS6KA30.21975276
148NLK0.21328921
149PIK3CG0.20316602
150TEC0.19681170
151PRKCB0.19651405
152CHUK0.19633804
153PRKCA0.19262143
154MAPK90.18492436
155NEK60.18091409
156SGK30.17865666
157PRKCG0.17773017
158RIPK10.17290217
159MAPK100.16467308
160CDK120.15666331
161AKT10.15529559
162SGK2230.15066710
163SGK4940.15066710
164SGK20.14404200

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.67281535
2Protein export_Homo sapiens_hsa030604.55544862
3Sulfur metabolism_Homo sapiens_hsa009203.36619031
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.30337288
5* Insulin secretion_Homo sapiens_hsa049113.10608771
6Type II diabetes mellitus_Homo sapiens_hsa049302.97750888
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.82193065
8Type I diabetes mellitus_Homo sapiens_hsa049402.41475043
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.21882556
10Selenocompound metabolism_Homo sapiens_hsa004502.00268234
11Vibrio cholerae infection_Homo sapiens_hsa051101.84931575
12Phototransduction_Homo sapiens_hsa047441.81512015
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72391044
14Cocaine addiction_Homo sapiens_hsa050301.61903127
15Nicotine addiction_Homo sapiens_hsa050331.58052797
16N-Glycan biosynthesis_Homo sapiens_hsa005101.57227786
17Lysosome_Homo sapiens_hsa041421.50200316
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.47372808
19Pancreatic secretion_Homo sapiens_hsa049721.44530735
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25926869
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24782377
22Vitamin B6 metabolism_Homo sapiens_hsa007501.24573056
23Caffeine metabolism_Homo sapiens_hsa002321.23946354
24Insulin resistance_Homo sapiens_hsa049311.21650243
25beta-Alanine metabolism_Homo sapiens_hsa004101.21106053
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19657346
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14301311
28Taste transduction_Homo sapiens_hsa047421.13094675
29Amphetamine addiction_Homo sapiens_hsa050311.11666842
30Propanoate metabolism_Homo sapiens_hsa006401.11197243
31Glucagon signaling pathway_Homo sapiens_hsa049221.04872758
32Non-homologous end-joining_Homo sapiens_hsa034501.02884037
33Tryptophan metabolism_Homo sapiens_hsa003801.01764513
34ABC transporters_Homo sapiens_hsa020101.01381867
35Prolactin signaling pathway_Homo sapiens_hsa049171.01301396
36Salivary secretion_Homo sapiens_hsa049701.00703778
37* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99545631
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99300703
39Other glycan degradation_Homo sapiens_hsa005110.97208217
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94095829
41Ether lipid metabolism_Homo sapiens_hsa005650.94019626
42Fatty acid metabolism_Homo sapiens_hsa012120.91360419
43Thyroid hormone synthesis_Homo sapiens_hsa049180.90883543
44Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90659688
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86167519
46Long-term potentiation_Homo sapiens_hsa047200.85928064
47Circadian rhythm_Homo sapiens_hsa047100.83803461
48Hedgehog signaling pathway_Homo sapiens_hsa043400.81192702
49Folate biosynthesis_Homo sapiens_hsa007900.80816686
50Dopaminergic synapse_Homo sapiens_hsa047280.80150720
51Galactose metabolism_Homo sapiens_hsa000520.77613464
52Butanoate metabolism_Homo sapiens_hsa006500.77382342
53Cholinergic synapse_Homo sapiens_hsa047250.76204074
54Regulation of autophagy_Homo sapiens_hsa041400.76060416
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.75821769
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75107655
57Estrogen signaling pathway_Homo sapiens_hsa049150.72466091
58Cardiac muscle contraction_Homo sapiens_hsa042600.69747256
59Prion diseases_Homo sapiens_hsa050200.69638332
60Glycerolipid metabolism_Homo sapiens_hsa005610.69262336
61Circadian entrainment_Homo sapiens_hsa047130.68396606
62Peroxisome_Homo sapiens_hsa041460.68349908
63Synaptic vesicle cycle_Homo sapiens_hsa047210.66950341
64GABAergic synapse_Homo sapiens_hsa047270.65458213
65Nitrogen metabolism_Homo sapiens_hsa009100.64359186
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64080651
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63699956
68Serotonergic synapse_Homo sapiens_hsa047260.63580839
69Basal cell carcinoma_Homo sapiens_hsa052170.63269337
70Fat digestion and absorption_Homo sapiens_hsa049750.62327018
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61606945
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60742707
73Fanconi anemia pathway_Homo sapiens_hsa034600.60599966
74Insulin signaling pathway_Homo sapiens_hsa049100.60220812
75mTOR signaling pathway_Homo sapiens_hsa041500.58751507
76Starch and sucrose metabolism_Homo sapiens_hsa005000.58385969
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58093622
78Oxidative phosphorylation_Homo sapiens_hsa001900.56540070
79Collecting duct acid secretion_Homo sapiens_hsa049660.55622987
80Fatty acid degradation_Homo sapiens_hsa000710.54391059
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53855915
82Mineral absorption_Homo sapiens_hsa049780.53486357
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53235693
84RNA degradation_Homo sapiens_hsa030180.53213622
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52505730
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52090353
87Lysine degradation_Homo sapiens_hsa003100.51418376
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50725807
89Basal transcription factors_Homo sapiens_hsa030220.49362493
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.49323536
91Alcoholism_Homo sapiens_hsa050340.47969625
92Retinol metabolism_Homo sapiens_hsa008300.46877379
93Vitamin digestion and absorption_Homo sapiens_hsa049770.46385017
94Sphingolipid metabolism_Homo sapiens_hsa006000.46179852
95Olfactory transduction_Homo sapiens_hsa047400.45916793
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45596769
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.45305224
98Calcium signaling pathway_Homo sapiens_hsa040200.44409131
99Arachidonic acid metabolism_Homo sapiens_hsa005900.44308300
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42937230
101Phenylalanine metabolism_Homo sapiens_hsa003600.42577649
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42426441
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41547732
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41487948
105Renin secretion_Homo sapiens_hsa049240.41153361
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40816053
107TGF-beta signaling pathway_Homo sapiens_hsa043500.40529976
108Dilated cardiomyopathy_Homo sapiens_hsa054140.40515654
109Dorso-ventral axis formation_Homo sapiens_hsa043200.40448932
110AMPK signaling pathway_Homo sapiens_hsa041520.40369352
111Fatty acid biosynthesis_Homo sapiens_hsa000610.40117155
112Protein digestion and absorption_Homo sapiens_hsa049740.39715860
113Morphine addiction_Homo sapiens_hsa050320.37235392
114Thyroid cancer_Homo sapiens_hsa052160.36879322
115Linoleic acid metabolism_Homo sapiens_hsa005910.35897219
116Prostate cancer_Homo sapiens_hsa052150.35545245
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34223198
118Inositol phosphate metabolism_Homo sapiens_hsa005620.32385636
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32367398
120Bladder cancer_Homo sapiens_hsa052190.30769238
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30058170
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.29662530
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28270218
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.26865499
125Histidine metabolism_Homo sapiens_hsa003400.25902260
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23076000
127Gap junction_Homo sapiens_hsa045400.22609072
128Glioma_Homo sapiens_hsa052140.22171287
129Ovarian steroidogenesis_Homo sapiens_hsa049130.21625062
130Melanogenesis_Homo sapiens_hsa049160.21011530
131Endometrial cancer_Homo sapiens_hsa052130.20940725
132Antigen processing and presentation_Homo sapiens_hsa046120.20277631
133Fatty acid elongation_Homo sapiens_hsa000620.19628812
134Renal cell carcinoma_Homo sapiens_hsa052110.18480760
135FoxO signaling pathway_Homo sapiens_hsa040680.18436299
136Glutamatergic synapse_Homo sapiens_hsa047240.18132692
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17963207
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17304475
139* cAMP signaling pathway_Homo sapiens_hsa040240.16836526
140Gastric acid secretion_Homo sapiens_hsa049710.15872696
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14580229
142GnRH signaling pathway_Homo sapiens_hsa049120.11499571
143Long-term depression_Homo sapiens_hsa047300.11413388

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