GLP2R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1photoreceptor cell maintenance (GO:0045494)9.14149018
2midgut development (GO:0007494)9.08193244
3detection of light stimulus involved in visual perception (GO:0050908)8.73533002
4detection of light stimulus involved in sensory perception (GO:0050962)8.73533002
5photoreceptor cell development (GO:0042461)8.66788708
6eye photoreceptor cell development (GO:0042462)8.35484529
7protein-chromophore linkage (GO:0018298)8.35379804
8urea cycle (GO:0000050)8.15474112
9homocysteine metabolic process (GO:0050667)8.11874302
10phototransduction (GO:0007602)8.02717320
11phototransduction, visible light (GO:0007603)8.00971224
12detection of visible light (GO:0009584)7.71484232
13detection of light stimulus (GO:0009583)7.60343721
14positive regulation of guanylate cyclase activity (GO:0031284)7.59910664
15urea metabolic process (GO:0019627)7.43015239
16regulation of guanylate cyclase activity (GO:0031282)6.87872518
17nitrogen cycle metabolic process (GO:0071941)6.63305186
18retinal rod cell development (GO:0046548)6.59615977
19negative regulation of complement activation (GO:0045916)6.56698281
20visual perception (GO:0007601)6.49907394
21positive regulation of vascular permeability (GO:0043117)6.45987511
22sensory perception of light stimulus (GO:0050953)6.42144827
23nuclear pore complex assembly (GO:0051292)6.34855999
24folic acid metabolic process (GO:0046655)6.22043600
25citrulline metabolic process (GO:0000052)6.19363921
26cGMP-mediated signaling (GO:0019934)6.15950151
27GMP metabolic process (GO:0046037)6.14722128
28negative regulation of protein activation cascade (GO:2000258)5.90602441
29citrulline biosynthetic process (GO:0019240)5.76984384
30detection of external stimulus (GO:0009581)5.40886292
31cellular response to light stimulus (GO:0071482)5.40708017
32nuclear pore organization (GO:0006999)5.30333554
33detection of abiotic stimulus (GO:0009582)5.28846601
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.26349833
35diaphragm development (GO:0060539)5.13304270
36cAMP catabolic process (GO:0006198)5.09567808
37regulation of clathrin-mediated endocytosis (GO:2000369)5.08539448
38photoreceptor cell differentiation (GO:0046530)5.04219998
39eye photoreceptor cell differentiation (GO:0001754)5.04219998
40response to growth hormone (GO:0060416)4.90329325
41negative regulation of humoral immune response (GO:0002921)4.88522374
42regulation of cGMP metabolic process (GO:0030823)4.80832608
43response to dexamethasone (GO:0071548)4.69063776
44pore complex assembly (GO:0046931)4.65451153
45protein localization to synapse (GO:0035418)4.65228523
46retina development in camera-type eye (GO:0060041)4.57313127
47positive regulation of vesicle fusion (GO:0031340)4.48839526
48hepatocyte differentiation (GO:0070365)4.48462808
49positive regulation of cGMP biosynthetic process (GO:0030828)4.48125485
50regulation of short-term neuronal synaptic plasticity (GO:0048172)4.47760320
51cyclic nucleotide catabolic process (GO:0009214)4.42020035
52skeletal muscle organ development (GO:0060538)4.41539384
53positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.40716674
54negative regulation of vascular permeability (GO:0043116)4.39474378
55polyketide metabolic process (GO:0030638)4.32445936
56doxorubicin metabolic process (GO:0044598)4.32445936
57daunorubicin metabolic process (GO:0044597)4.32445936
58response to histamine (GO:0034776)4.28975390
59cell morphogenesis involved in neuron differentiation (GO:0048667)4.26043528
60cellular response to fatty acid (GO:0071398)4.24269737
61regulation of cGMP biosynthetic process (GO:0030826)4.21423573
62synaptic vesicle docking involved in exocytosis (GO:0016081)4.11793001
63detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.08883629
64receptor guanylyl cyclase signaling pathway (GO:0007168)4.08558742
65nucleobase-containing small molecule interconversion (GO:0015949)3.99484386
66positive regulation of cGMP metabolic process (GO:0030825)3.95972254
67positive regulation of neurotransmitter transport (GO:0051590)3.90558286
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.90551666
69folic acid transport (GO:0015884)3.83100570
70aminoglycoside antibiotic metabolic process (GO:0030647)3.80599387
71adaptation of signaling pathway (GO:0023058)3.76276454
72mitotic chromosome condensation (GO:0007076)3.74443661
73regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.73152202
74establishment of apical/basal cell polarity (GO:0035089)3.68605170
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68215304
76glomerular visceral epithelial cell development (GO:0072015)3.66989640
77response to food (GO:0032094)3.58671963
78regulation of voltage-gated calcium channel activity (GO:1901385)3.54956302
79positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.52927544
80triglyceride catabolic process (GO:0019433)3.48441896
81cysteine metabolic process (GO:0006534)3.45631710
82cellular response to radiation (GO:0071478)3.44946362
83synaptic vesicle maturation (GO:0016188)3.40516819
84nonmotile primary cilium assembly (GO:0035058)3.34941332
85response to nitrosative stress (GO:0051409)3.34598248
86regulation of translational fidelity (GO:0006450)3.34476223
87glutamine metabolic process (GO:0006541)3.33758959
88notochord development (GO:0030903)3.32319741
89positive regulation of neurotransmitter secretion (GO:0001956)3.29738017
90startle response (GO:0001964)3.29729697
91estrogen biosynthetic process (GO:0006703)3.27771322
92sensory perception (GO:0007600)3.27297603
93regulation of axon extension involved in axon guidance (GO:0048841)3.25014801
94cellular protein complex localization (GO:0034629)3.23170519
95regulation of vesicle fusion (GO:0031338)3.22908876
96membrane hyperpolarization (GO:0060081)3.21830871
97DNA unwinding involved in DNA replication (GO:0006268)3.18411148
98regulation of mitotic spindle organization (GO:0060236)3.18084426
99regulation of synaptic vesicle transport (GO:1902803)3.16118795
100COPI coating of Golgi vesicle (GO:0048205)3.15118602
101Golgi transport vesicle coating (GO:0048200)3.15118602
102mitotic sister chromatid segregation (GO:0000070)3.15045868
103regulation of synaptic vesicle exocytosis (GO:2000300)3.14544045
104detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.13100834
105tricarboxylic acid metabolic process (GO:0072350)3.11549500
106glomerular epithelial cell development (GO:0072310)3.09983925
107ribosome assembly (GO:0042255)3.09781366
108neutral lipid catabolic process (GO:0046461)3.08351995
109acylglycerol catabolic process (GO:0046464)3.08351995
110NADH metabolic process (GO:0006734)3.08058708
111short-term memory (GO:0007614)3.06983527
112DNA strand elongation involved in DNA replication (GO:0006271)3.04529386
113glycogen catabolic process (GO:0005980)3.01978249
114positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.01956708
115glucan catabolic process (GO:0009251)3.01416135
116presynaptic membrane assembly (GO:0097105)3.00023137
117chemosensory behavior (GO:0007635)2.99749301
118negative regulation of gluconeogenesis (GO:0045721)2.99645390
119phospholipid translocation (GO:0045332)2.98620837
120lipid translocation (GO:0034204)2.98620837
121positive regulation of membrane potential (GO:0045838)2.97973392
122neuron cell-cell adhesion (GO:0007158)2.97511547
123response to light stimulus (GO:0009416)2.94819440
124regulation of type B pancreatic cell apoptotic process (GO:2000674)2.91362915
125DNA strand elongation (GO:0022616)2.90583693
126sister chromatid segregation (GO:0000819)2.89229146
127mitotic nuclear envelope disassembly (GO:0007077)2.89185853
128retina layer formation (GO:0010842)2.89154289
129positive regulation of sodium ion transmembrane transport (GO:1902307)2.89066646
130establishment of monopolar cell polarity (GO:0061162)2.87856767
131establishment or maintenance of monopolar cell polarity (GO:0061339)2.87856767
132regulation of axon guidance (GO:1902667)2.87138851
133negative regulation of hormone metabolic process (GO:0032351)2.84827916
134regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84178113
135folic acid-containing compound metabolic process (GO:0006760)2.83748867
136biotin metabolic process (GO:0006768)2.83149955
137axonal fasciculation (GO:0007413)2.82960094
138glutamine family amino acid biosynthetic process (GO:0009084)2.81693571
139regulation of postsynaptic membrane potential (GO:0060078)2.80403420
140DNA replication initiation (GO:0006270)2.80105264
141telomere maintenance via semi-conservative replication (GO:0032201)2.80007948
142early endosome to late endosome transport (GO:0045022)2.79854770
143regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.79685545
144glutamate secretion (GO:0014047)2.78825747
145detection of chemical stimulus involved in sensory perception (GO:0050907)2.78801606
146cellular polysaccharide catabolic process (GO:0044247)2.78536380
147positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.78244485
148tricarboxylic acid cycle (GO:0006099)2.78233560
149retina vasculature morphogenesis in camera-type eye (GO:0061299)2.78211196
150positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.77993523
151glycoside metabolic process (GO:0016137)2.76809752
152tRNA methylation (GO:0030488)2.76317662
153mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.76106106
154regulation of centriole replication (GO:0046599)2.74273307
155nuclear envelope disassembly (GO:0051081)2.73380557
156membrane disassembly (GO:0030397)2.73380557
157neuron development (GO:0048666)2.72713342
158branching involved in salivary gland morphogenesis (GO:0060445)2.72380208
159synaptic transmission, glutamatergic (GO:0035249)2.71584441
160primary alcohol catabolic process (GO:0034310)2.70727528
161regulation of neurotransmitter secretion (GO:0046928)2.70073716
162behavioral response to ethanol (GO:0048149)2.69418398
163synaptic vesicle endocytosis (GO:0048488)2.69342809
164iron ion import (GO:0097286)2.68678120
165cellular potassium ion homeostasis (GO:0030007)2.68572292
166response to laminar fluid shear stress (GO:0034616)2.68165129
167synaptic vesicle exocytosis (GO:0016079)2.65999019
168regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64892181
169regulation of chromatin binding (GO:0035561)2.64691796
170postsynaptic membrane organization (GO:0001941)2.64198896
171locomotory exploration behavior (GO:0035641)2.63888590
172positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.63833826
173UV protection (GO:0009650)2.63717990
174L-alpha-amino acid transmembrane transport (GO:1902475)2.63552926
175protein complex localization (GO:0031503)2.63477247
176negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.63150751
177carnitine shuttle (GO:0006853)2.62556694
178central nervous system projection neuron axonogenesis (GO:0021952)2.62222892
179glomerular basement membrane development (GO:0032836)2.60724523
180regulation of steroid hormone biosynthetic process (GO:0090030)2.59746928
181fatty acid homeostasis (GO:0055089)2.59132408
182ribosome biogenesis (GO:0042254)2.57201284
183neuron-neuron synaptic transmission (GO:0007270)2.57022610
184CDP-diacylglycerol biosynthetic process (GO:0016024)2.56579278
185regulation of vascular permeability (GO:0043114)2.55941617
186positive regulation of ERBB signaling pathway (GO:1901186)2.54807671
187regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51466029
188regulation of spindle organization (GO:0090224)2.51129012
189neurotransmitter-gated ion channel clustering (GO:0072578)2.50684952
190negative regulation of receptor-mediated endocytosis (GO:0048261)2.50379598
191regulation of centrosome cycle (GO:0046605)2.49948898
192protein localization to chromosome, centromeric region (GO:0071459)2.49752845
193regulation of complement activation (GO:0030449)2.48184016
194carnitine transmembrane transport (GO:1902603)2.47754223
195polarized epithelial cell differentiation (GO:0030859)2.47629221
196polysaccharide catabolic process (GO:0000272)2.46002018
197sulfur amino acid metabolic process (GO:0000096)2.44995128
198regulation of rhodopsin mediated signaling pathway (GO:0022400)13.7023681
199rhodopsin mediated signaling pathway (GO:0016056)13.4063395
200retinal cone cell development (GO:0046549)11.6196035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.44595228
2ZNF263_19887448_ChIP-Seq_K562_Human6.77156334
3GBX2_23144817_ChIP-Seq_PC3_Human4.69383640
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.33238647
5EZH2_22144423_ChIP-Seq_EOC_Human3.89422393
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.24661472
7DROSHA_22980978_ChIP-Seq_HELA_Human3.19139606
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.04693886
9AR_21909140_ChIP-Seq_LNCAP_Human2.91939209
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84935930
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.58518368
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43289894
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40323074
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36853182
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.36370381
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32917130
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24443401
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.17572818
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.14761901
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14410496
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12144071
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10388315
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08339633
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02367351
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02029700
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.01798203
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01782688
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.01344859
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99760155
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98349807
31CLOCK_20551151_ChIP-Seq_293T_Human1.97534195
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96949980
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95027128
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94571970
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93760723
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92957811
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91653273
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87990610
39REST_21632747_ChIP-Seq_MESCs_Mouse1.86253640
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83286413
41HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.81318278
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81290061
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78463942
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78463942
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76788584
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.75858261
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74741299
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74156268
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.72282084
50XRN2_22483619_ChIP-Seq_HELA_Human1.71862837
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.69466265
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65936585
53SMAD4_21799915_ChIP-Seq_A2780_Human1.65626225
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65570644
55VDR_22108803_ChIP-Seq_LS180_Human1.62410801
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60788993
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58069099
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57765512
59AR_21572438_ChIP-Seq_LNCaP_Human1.57407955
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.57101706
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57018099
62DCP1A_22483619_ChIP-Seq_HELA_Human1.56623741
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56591213
64TP53_16413492_ChIP-PET_HCT116_Human1.56429185
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55028872
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54656533
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54310243
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.52623789
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.52408198
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52050859
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51793375
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51392886
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51217391
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50490521
75BCAT_22108803_ChIP-Seq_LS180_Human1.48001573
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47766730
77FUS_26573619_Chip-Seq_HEK293_Human1.47673714
78TFEB_21752829_ChIP-Seq_HELA_Human1.46351280
79CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.45448643
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45275593
81SMC4_20622854_ChIP-Seq_HELA_Human1.45089915
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.45064660
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44965655
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44720410
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44720410
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.44570857
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.42509623
88STAT3_23295773_ChIP-Seq_U87_Human1.41798011
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41668738
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.40695640
91P300_19829295_ChIP-Seq_ESCs_Human1.40341993
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39696540
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.39225419
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38754732
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38381523
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38362320
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.38071667
98AR_19668381_ChIP-Seq_PC3_Human1.37676617
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37465174
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35682747
101* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34974978
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34947768
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33942247
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.33462143
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.30197228
106RACK7_27058665_Chip-Seq_MCF-7_Human1.29435895
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29257437
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28986108
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28715898
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28040683
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27283588
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27067352
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25873813
114TTF2_22483619_ChIP-Seq_HELA_Human1.25863033
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25297863
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.24683084
117STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23560347
118E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23224372
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23024319
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22367588
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22140535
122AHR_22903824_ChIP-Seq_MCF-7_Human1.21843549
123ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21407300
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.21209280
125MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20372470
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18924138
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18669385
128GATA6_25053715_ChIP-Seq_YYC3_Human1.18586258
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18577565
130TCF4_23295773_ChIP-Seq_U87_Human1.16899489
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16354544
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15111059
133WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14513339
134P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13405503
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13383069
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12818515
137AR_25329375_ChIP-Seq_VCAP_Human1.10844334
138RING1B_27294783_Chip-Seq_ESCs_Mouse1.10598568
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09870734
140YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09383354
141ATF3_27146783_Chip-Seq_COLON_Human1.09370548
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09310003
143SOX2_21211035_ChIP-Seq_LN229_Gbm1.09214655
144CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09158542
145SMAD4_21741376_ChIP-Seq_HESCs_Human1.08016001
146IGF1R_20145208_ChIP-Seq_DFB_Human1.07407330
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07394628
148RING1B_27294783_Chip-Seq_NPCs_Mouse1.06900598
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05135704
150SOX17_20123909_ChIP-Seq_XEN_Mouse1.04680837
151TBL1_22424771_ChIP-Seq_293T_Human1.04236242
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04010504
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03636026
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02529115
155RUNX2_22187159_ChIP-Seq_PCA_Human1.01583743
156NANOG_18555785_Chip-Seq_ESCs_Mouse1.01432813
157PRDM14_20953172_ChIP-Seq_ESCs_Human1.00824233
158CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00808191
159E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00771183
160* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00613356
161HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99179274
162EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98843712
163THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98660391
164ARNT_22903824_ChIP-Seq_MCF-7_Human0.98504952
165PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98299705
166KDM2B_26808549_Chip-Seq_K562_Human0.97525779
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96780746
168ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96723799
169TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96566881
170NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95255537
171ELK1_19687146_ChIP-ChIP_HELA_Human0.95226900
172KDM2B_26808549_Chip-Seq_REH_Human0.95080727
173CTCF_27219007_Chip-Seq_Bcells_Human0.94737460
174SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94547290
175ZNF274_21170338_ChIP-Seq_K562_Hela0.94071856
176PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93796175
177NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93551207
178SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93044949
179RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92794951
180ETS1_20019798_ChIP-Seq_JURKAT_Human0.92696334
181TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92461195
182UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92369127
183RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91895107
184CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91256791
185ERG_21242973_ChIP-ChIP_JURKAT_Human0.91220289
186MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91117267
187UBF1/2_26484160_Chip-Seq_HMECs_Human0.90857170
188ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89376836
189CHD1_26751641_Chip-Seq_LNCaP_Human0.88702367
190NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87817151
191GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87463653
192* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87097789
193KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86083722
194RXR_22158963_ChIP-Seq_LIVER_Mouse0.86067375
195NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86054057
196TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85703241
197TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85703178
198KDM5A_27292631_Chip-Seq_BREAST_Human0.82158889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation9.11332252
2MP0005551_abnormal_eye_electrophysiolog8.48059635
3MP0005253_abnormal_eye_physiology5.89066607
4MP0006072_abnormal_retinal_apoptosis5.42940952
5MP0000013_abnormal_adipose_tissue4.31250585
6MP0002877_abnormal_melanocyte_morpholog3.93335569
7MP0003880_abnormal_central_pattern3.72028870
8MP0005623_abnormal_meninges_morphology3.54317685
9MP0003950_abnormal_plasma_membrane3.29144136
10MP0005195_abnormal_posterior_eye3.22714101
11MP0002090_abnormal_vision2.98554006
12MP0010234_abnormal_vibrissa_follicle2.96173147
13MP0000003_abnormal_adipose_tissue2.95954663
14MP0005423_abnormal_somatic_nervous2.89314987
15MP0005391_vision/eye_phenotype2.85870322
16MP0001324_abnormal_eye_pigmentation2.85759714
17MP0002009_preneoplasia2.74997393
18MP0010094_abnormal_chromosome_stability2.58464838
19MP0010352_gastrointestinal_tract_polyps2.55335048
20MP0000579_abnormal_nail_morphology2.54918105
21MP0004859_abnormal_synaptic_plasticity2.54325196
22MP0002229_neurodegeneration2.52080171
23MP0004957_abnormal_blastocyst_morpholog2.49739962
24MP0001661_extended_life_span2.45475003
25MP0008057_abnormal_DNA_replication2.31217492
26MP0001348_abnormal_lacrimal_gland2.25146842
27MP0003283_abnormal_digestive_organ2.20658817
28MP0006292_abnormal_olfactory_placode2.14874391
29MP0008058_abnormal_DNA_repair2.14604486
30MP0003705_abnormal_hypodermis_morpholog2.14316485
31MP0003693_abnormal_embryo_hatching2.11264492
32MP0003111_abnormal_nucleus_morphology2.10063772
33MP0010307_abnormal_tumor_latency1.98563363
34MP0005360_urolithiasis1.98143114
35MP0003077_abnormal_cell_cycle1.96129674
36MP0002638_abnormal_pupillary_reflex1.91279828
37MP0000490_abnormal_crypts_of1.90529885
38MP0005332_abnormal_amino_acid1.90199399
39MP0002752_abnormal_somatic_nervous1.90074794
40MP0003635_abnormal_synaptic_transmissio1.83272405
41MP0005076_abnormal_cell_differentiation1.82120217
42MP0005375_adipose_tissue_phenotype1.81530773
43MP0001968_abnormal_touch/_nociception1.80132660
44MP0004185_abnormal_adipocyte_glucose1.79788726
45MP0003566_abnormal_cell_adhesion1.64381981
46MP0001764_abnormal_homeostasis1.61585319
47MP0006138_congestive_heart_failure1.61468504
48MP0004270_analgesia1.59966802
49MP0008932_abnormal_embryonic_tissue1.58137771
50MP0002882_abnormal_neuron_morphology1.57582379
51MP0004885_abnormal_endolymph1.55121972
52MP0001502_abnormal_circadian_rhythm1.53692979
53MP0008438_abnormal_cutaneous_collagen1.50495864
54MP0002064_seizures1.46084059
55MP0010030_abnormal_orbit_morphology1.44599225
56MP0005501_abnormal_skin_physiology1.43212552
57MP0003786_premature_aging1.42859264
58MP0005085_abnormal_gallbladder_physiolo1.39856618
59MP0001486_abnormal_startle_reflex1.36897393
60MP0002063_abnormal_learning/memory/cond1.34233565
61MP0002272_abnormal_nervous_system1.30138409
62MP0005666_abnormal_adipose_tissue1.29811986
63MP0004019_abnormal_vitamin_homeostasis1.29140987
64MP0009745_abnormal_behavioral_response1.28535966
65MP0001986_abnormal_taste_sensitivity1.24132283
66MP0002572_abnormal_emotion/affect_behav1.23271270
67MP0003186_abnormal_redox_activity1.22460097
68MP0000733_abnormal_muscle_development1.22189309
69MP0002234_abnormal_pharynx_morphology1.18795529
70MP0003718_maternal_effect1.18047732
71MP0005670_abnormal_white_adipose1.16742267
72MP0008007_abnormal_cellular_replicative1.15259707
73MP0002971_abnormal_brown_adipose1.15126844
74MP0002697_abnormal_eye_size1.13123302
75MP0004233_abnormal_muscle_weight1.11963289
76MP0009697_abnormal_copulation1.08149768
77MP0003183_abnormal_peptide_metabolism1.06768932
78MP0005584_abnormal_enzyme/coenzyme_acti1.06090067
79MP0005319_abnormal_enzyme/_coenzyme1.05580916
80MP0003868_abnormal_feces_composition1.04738409
81MP0009643_abnormal_urine_homeostasis1.04625599
82MP0000350_abnormal_cell_proliferation1.04493013
83MP0003806_abnormal_nucleotide_metabolis1.03750746
84MP0004130_abnormal_muscle_cell1.01516535
85MP0000537_abnormal_urethra_morphology1.00430900
86MP0002734_abnormal_mechanical_nocicepti1.00142200
87MP0002139_abnormal_hepatobiliary_system0.98998450
88MP0009046_muscle_twitch0.98568047
89MP0005647_abnormal_sex_gland0.96817904
90MP0002067_abnormal_sensory_capabilities0.96106755
91MP0003984_embryonic_growth_retardation0.95942543
92MP0003453_abnormal_keratinocyte_physiol0.95583734
93MP0003252_abnormal_bile_duct0.95380535
94MP0002970_abnormal_white_adipose0.94394398
95MP0002060_abnormal_skin_morphology0.93872699
96MP0002166_altered_tumor_susceptibility0.93775437
97MP0002080_prenatal_lethality0.93184324
98MP0002088_abnormal_embryonic_growth/wei0.93029823
99MP0001672_abnormal_embryogenesis/_devel0.92213691
100MP0005380_embryogenesis_phenotype0.92213691
101MP0002822_catalepsy0.92142105
102MP0002269_muscular_atrophy0.91832301
103MP0008775_abnormal_heart_ventricle0.90907288
104MP0001501_abnormal_sleep_pattern0.90656876
105MP0009780_abnormal_chondrocyte_physiolo0.88881026
106MP0003045_fibrosis0.88736511
107MP0002736_abnormal_nociception_after0.87831057
108MP0005451_abnormal_body_composition0.87588019
109MP0002735_abnormal_chemical_nociception0.87010338
110MP0001730_embryonic_growth_arrest0.86277257
111MP0000462_abnormal_digestive_system0.86236437
112MP0004808_abnormal_hematopoietic_stem0.83862584
113MP0000762_abnormal_tongue_morphology0.83450609
114MP0004272_abnormal_basement_membrane0.82172041
115MP0002086_abnormal_extraembryonic_tissu0.81173691
116MP0003656_abnormal_erythrocyte_physiolo0.80965242
117MP0002653_abnormal_ependyma_morphology0.80083224
118MP0004084_abnormal_cardiac_muscle0.79869648
119MP0004087_abnormal_muscle_fiber0.79090834
120MP0002896_abnormal_bone_mineralization0.78583294
121MP0004782_abnormal_surfactant_physiolog0.77539381
122MP0001984_abnormal_olfaction0.77146906
123MP0002733_abnormal_thermal_nociception0.76338575
124MP0001697_abnormal_embryo_size0.76217815
125MP0005083_abnormal_biliary_tract0.75987110
126MP0001243_abnormal_dermal_layer0.75433010
127MP0000778_abnormal_nervous_system0.75286112
128MP0002796_impaired_skin_barrier0.75159852
129MP0001849_ear_inflammation0.74804085
130MP0002084_abnormal_developmental_patter0.73988470
131MP0004133_heterotaxia0.73405108
132MP0001970_abnormal_pain_threshold0.73204130
133MP0005334_abnormal_fat_pad0.73109363
134MP0002396_abnormal_hematopoietic_system0.72729117
135MP0005621_abnormal_cell_physiology0.72669235
136MP0004858_abnormal_nervous_system0.72488121
137MP0000467_abnormal_esophagus_morphology0.72164163
138MP0001963_abnormal_hearing_physiology0.71708720
139MP0005409_darkened_coat_color0.71581164
140MP0010771_integument_phenotype0.70712408
141MP0000609_abnormal_liver_physiology0.70432179
142MP0005165_increased_susceptibility_to0.70430334
143MP0008260_abnormal_autophagy0.70373538
144MP0000759_abnormal_skeletal_muscle0.69471496
145MP0003959_abnormal_lean_body0.68757277
146MP0000358_abnormal_cell_content/0.67987224
147MP0004742_abnormal_vestibular_system0.66586034
148MP0010386_abnormal_urinary_bladder0.66014772
149MP0005197_abnormal_uvea_morphology0.65404663
150MP0003634_abnormal_glial_cell0.63527803
151MP0004811_abnormal_neuron_physiology0.63471292
152MP0005084_abnormal_gallbladder_morpholo0.62846153
153MP0002184_abnormal_innervation0.60713685
154MP0000678_abnormal_parathyroid_gland0.59751960
155MP0000955_abnormal_spinal_cord0.58692534
156MP0003879_abnormal_hair_cell0.58146266
157MP0008569_lethality_at_weaning0.58024401
158MP0005386_behavior/neurological_phenoty0.57564347
159MP0004924_abnormal_behavior0.57564347
160MP0002332_abnormal_exercise_endurance0.56033354
161MP0002066_abnormal_motor_capabilities/c0.55488158
162MP0005394_taste/olfaction_phenotype0.53783285
163MP0005499_abnormal_olfactory_system0.53783285
164MP0002928_abnormal_bile_duct0.51233434
165MP0005595_abnormal_vascular_smooth0.49668774
166MP0001188_hyperpigmentation0.49172424
167MP0005187_abnormal_penis_morphology0.48241361
168MP0004043_abnormal_pH_regulation0.47258690
169MP0001440_abnormal_grooming_behavior0.47111968
170MP0004142_abnormal_muscle_tone0.46527254
171MP0002152_abnormal_brain_morphology0.45030225
172MP0002876_abnormal_thyroid_physiology0.44941071
173MP0002557_abnormal_social/conspecific_i0.44926023
174MP0000026_abnormal_inner_ear0.44769652
175MP0003633_abnormal_nervous_system0.44344936
176MP0000631_abnormal_neuroendocrine_gland0.43617652
177MP0008004_abnormal_stomach_pH0.41058192
178MP0003690_abnormal_glial_cell0.41023948
179MP0005646_abnormal_pituitary_gland0.40645825
180MP0010678_abnormal_skin_adnexa0.40532633
181MP0001177_atelectasis0.40474526
182MP0002127_abnormal_cardiovascular_syste0.39067806
183MP0003631_nervous_system_phenotype0.36956572
184MP0006276_abnormal_autonomic_nervous0.36569507
185MP0003075_altered_response_to0.36563714
186MP0002751_abnormal_autonomic_nervous0.35385503
187MP0004215_abnormal_myocardial_fiber0.34843318
188MP0000920_abnormal_myelination0.34724831
189MP0003632_abnormal_nervous_system0.33646689
190MP0002102_abnormal_ear_morphology0.33398396
191MP0000681_abnormal_thyroid_gland0.30556604
192MP0003303_peritoneal_inflammation0.30413909
193MP0000569_abnormal_digit_pigmentation0.30343797

Predicted human phenotypes

RankGene SetZ-score
1Dyschromatopsia (HP:0007641)9.18661135
2Absent rod-and cone-mediated responses on ERG (HP:0007688)9.18488051
3Abnormal rod and cone electroretinograms (HP:0008323)8.68349331
4Central scotoma (HP:0000603)7.97871798
5Pigmentary retinal degeneration (HP:0001146)7.95286740
6Abnormality of macular pigmentation (HP:0008002)7.75225295
7Attenuation of retinal blood vessels (HP:0007843)7.12562798
8Chorioretinal atrophy (HP:0000533)7.05981100
9Scotoma (HP:0000575)7.03371464
10Abnormality of glutamine family amino acid metabolism (HP:0010902)6.79262864
11Pendular nystagmus (HP:0012043)6.59439729
12Decreased central vision (HP:0007663)6.17951808
13Abolished electroretinogram (ERG) (HP:0000550)5.93421273
14Photophobia (HP:0000613)5.39526320
15Posterior subcapsular cataract (HP:0007787)5.28241711
16Type II diabetes mellitus (HP:0005978)5.21694273
17Choroideremia (HP:0001139)5.09024993
18Macular degeneration (HP:0000608)4.63375379
19Cone-rod dystrophy (HP:0000548)4.57639280
20Alkalosis (HP:0001948)4.54091026
21Severe visual impairment (HP:0001141)4.49711448
22Vitreoretinal degeneration (HP:0000655)4.42092550
23Keratoconus (HP:0000563)4.25419392
24Increased corneal curvature (HP:0100692)4.25419392
25Cerebellar dysplasia (HP:0007033)4.08775503
26Retinitis pigmentosa (HP:0000510)3.84591545
27Hypobetalipoproteinemia (HP:0003563)3.83968512
28Congenital sensorineural hearing impairment (HP:0008527)3.72870076
29Constricted visual fields (HP:0001133)3.72433117
30Abnormality of pyrimidine metabolism (HP:0004353)3.71443946
31Abnormality of monocarboxylic acid metabolism (HP:0010996)3.49149030
32Hyperammonemia (HP:0001987)3.47308998
33Osteolytic defects of the hand bones (HP:0009699)3.40164310
34Osteolytic defects of the phalanges of the hand (HP:0009771)3.40164310
35Elbow flexion contracture (HP:0002987)3.38346093
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.36976850
37Abnormality of alanine metabolism (HP:0010916)3.36976850
38Hyperalaninemia (HP:0003348)3.36976850
39Decreased electroretinogram (ERG) amplitude (HP:0000654)3.33887650
40Subcapsular cataract (HP:0000523)3.32685053
41Sparse lateral eyebrow (HP:0005338)3.16791085
42Submucous cleft hard palate (HP:0000176)3.12410566
43Cerebral edema (HP:0002181)3.09495235
44Ulnar bowing (HP:0003031)3.04856478
45Asymmetry of the thorax (HP:0001555)3.03018958
46Vertebral compression fractures (HP:0002953)3.02842523
47Malnutrition (HP:0004395)2.99046832
48Retinal atrophy (HP:0001105)2.93199547
49Short nail (HP:0001799)2.90335390
50Short chin (HP:0000331)2.85500237
51Abnormality of glycolysis (HP:0004366)2.84908415
52Progressive visual loss (HP:0000529)2.83533046
53Cutaneous melanoma (HP:0012056)2.74806951
54Calcaneovalgus deformity (HP:0001848)2.73133779
55Abnormality of the calcaneus (HP:0008364)2.70360084
56Increased serum pyruvate (HP:0003542)2.69289573
57Ragged-red muscle fibers (HP:0003200)2.68766061
58Impaired pain sensation (HP:0007328)2.66100391
59Abnormality of pain sensation (HP:0010832)2.66100391
60Microvesicular hepatic steatosis (HP:0001414)2.57807231
61Dysmetric saccades (HP:0000641)2.45908893
62Premature rupture of membranes (HP:0001788)2.45733131
63Achilles tendon contracture (HP:0001771)2.43443076
64Stroke (HP:0001297)2.43016816
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42227198
66Hypolipoproteinemia (HP:0010981)2.41016916
67Hypercholesterolemia (HP:0003124)2.35713613
68Optic disc pallor (HP:0000543)2.35695328
69Chromsome breakage (HP:0040012)2.35059802
70Gait imbalance (HP:0002141)2.33410138
71Squamous cell carcinoma (HP:0002860)2.33290325
72Broad face (HP:0000283)2.32420832
73Wide nasal bridge (HP:0000431)2.31751621
74Entropion (HP:0000621)2.28908212
75Congenital primary aphakia (HP:0007707)2.26601738
76Abnormality of the distal phalanges of the toes (HP:0010182)2.25603223
77Deformed tarsal bones (HP:0008119)2.25207121
78Abnormality of the Achilles tendon (HP:0005109)2.24696573
79Knee flexion contracture (HP:0006380)2.24028051
80Neurodegeneration (HP:0002180)2.23559575
81Progressive muscle weakness (HP:0003323)2.23507049
82Wormian bones (HP:0002645)2.22317229
83Abnormality of serum amino acid levels (HP:0003112)2.21240289
84Deviation of the thumb (HP:0009603)2.19245639
85Abnormality of oral frenula (HP:0000190)2.14952844
86Proximal placement of thumb (HP:0009623)2.13761183
87Partial agenesis of the corpus callosum (HP:0001338)2.12491674
88Febrile seizures (HP:0002373)2.12374914
89Nephrogenic diabetes insipidus (HP:0009806)2.11883860
90Renal duplication (HP:0000075)2.10784514
91Ankyloglossia (HP:0010296)2.09425483
92Termporal pattern (HP:0011008)2.06056716
93Insidious onset (HP:0003587)2.06056716
94Dysdiadochokinesis (HP:0002075)2.04738191
95Aplasia involving bones of the upper limbs (HP:0009823)2.02732673
96Aplasia of the phalanges of the hand (HP:0009802)2.02732673
97Aplasia involving bones of the extremities (HP:0009825)2.02732673
98Relative macrocephaly (HP:0004482)2.02618188
99Hypoplastic nipples (HP:0002557)2.00332843
100Congenital stationary night blindness (HP:0007642)12.9301129
101Bony spicule pigmentary retinopathy (HP:0007737)10.4841239
102Astrocytoma (HP:0009592)1.96791942
103Abnormality of the astrocytes (HP:0100707)1.96791942
104Flat acetabular roof (HP:0003180)1.95040689
105Hyperacusis (HP:0010780)1.94843949
106Natal tooth (HP:0000695)1.93286057
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.92236230
108Fibular hypoplasia (HP:0003038)1.90203205
109Epileptic encephalopathy (HP:0200134)1.87757685
110Medial flaring of the eyebrow (HP:0010747)1.87745886
111Selective tooth agenesis (HP:0001592)1.86594818
112Mitral stenosis (HP:0001718)1.86477795
113Polar cataract (HP:0010696)1.86083687
114Deep philtrum (HP:0002002)1.85079558
115Adducted thumb (HP:0001181)1.84582062
116Subacute progressive viral hepatitis (HP:0006572)1.82866387
117Hyperparathyroidism (HP:0000843)1.82707018
118Clumsiness (HP:0002312)1.77876164
119Truncal ataxia (HP:0002078)1.77060397
120Focal segmental glomerulosclerosis (HP:0000097)1.76919800
121Pancreatic fibrosis (HP:0100732)1.76875972
122Abnormality of the periventricular white matter (HP:0002518)1.76642952
123Bifid uvula (HP:0000193)1.74531697
124Overlapping toe (HP:0001845)1.74057008
125Megaloblastic anemia (HP:0001889)1.72133539
126Glomerulosclerosis (HP:0000096)1.70924193
127Abnormality of the nasal septum (HP:0000419)1.70342247
128Poor coordination (HP:0002370)1.68732491
129Genital tract atresia (HP:0001827)1.67620520
130Abnormality of the tricuspid valve (HP:0001702)1.67334557
131Myoglobinuria (HP:0002913)1.67010864
132Protruding tongue (HP:0010808)1.65028855
133Horizontal nystagmus (HP:0000666)1.64382525
134Neoplasm of head and neck (HP:0012288)1.63832859
135Esophageal neoplasm (HP:0100751)1.63832859
136Prominent nose (HP:0000448)1.63829506
137Sandal gap (HP:0001852)1.63143051
138Persistence of primary teeth (HP:0006335)1.62717857
139Ureteral duplication (HP:0000073)1.62617962
140Abnormality of sulfur amino acid metabolism (HP:0004339)1.62514573
141Vaginal atresia (HP:0000148)1.61924266
142Birth length less than 3rd percentile (HP:0003561)1.61337816
143Increased connective tissue (HP:0009025)1.58737805
144Delayed cranial suture closure (HP:0000270)1.57702705
145Overriding aorta (HP:0002623)1.57405307
146Micronodular cirrhosis (HP:0001413)1.57005777
147Abnormality of the ischium (HP:0003174)1.56769238
148Glioma (HP:0009733)1.56536756
149True hermaphroditism (HP:0010459)1.56270705
150Focal motor seizures (HP:0011153)1.55488907
151Autoamputation (HP:0001218)1.55197935
152Focal seizures (HP:0007359)1.54738867
153Tibial bowing (HP:0002982)1.54546789
154Oligodactyly (hands) (HP:0001180)1.47010978
155Cystic liver disease (HP:0006706)1.45681814
156Supernumerary nipples (HP:0002558)1.44542100
157Broad-based gait (HP:0002136)1.42492592
158Optic atrophy (HP:0000648)1.39954582
159Aplasia/Hypoplasia of the lens (HP:0008063)1.35491222
160Prolonged QT interval (HP:0001657)1.32122260
161Severe Myopia (HP:0011003)1.29363557
162Hyperventilation (HP:0002883)1.26308691
163Specific learning disability (HP:0001328)1.26207518
164Neoplasm of the heart (HP:0100544)1.24332875
165Turricephaly (HP:0000262)1.22583770
166Supranuclear gaze palsy (HP:0000605)1.22522397
167Left ventricular hypertrophy (HP:0001712)1.21647064
168Progressive cerebellar ataxia (HP:0002073)1.18162859
169Interstitial pulmonary disease (HP:0006530)1.17210929
170Retinal detachment (HP:0000541)1.15129144
171Dysmetria (HP:0001310)1.14325342
172Syncope (HP:0001279)1.14164558
173Abnormal EKG (HP:0003115)1.13167070
174Dialeptic seizures (HP:0011146)1.12996460
175Visual hallucinations (HP:0002367)1.10674450
176Postural instability (HP:0002172)1.09470311
177Pancreatic cysts (HP:0001737)1.09124053
178Aplasia/Hypoplasia of the tongue (HP:0010295)1.09121372
179Absence seizures (HP:0002121)1.07831239
180Excessive salivation (HP:0003781)1.06325492
181Drooling (HP:0002307)1.06325492
182Fair hair (HP:0002286)1.05838571
183Macroorchidism (HP:0000053)1.03925585
184Thoracic kyphosis (HP:0002942)1.02602987
185Atonic seizures (HP:0010819)1.02496730
186Scanning speech (HP:0002168)1.02330855
187Short foot (HP:0001773)1.01021758
188Insomnia (HP:0100785)1.00770710
189Astigmatism (HP:0000483)1.00318010
190Elfin facies (HP:0004428)0.99177270
191Flat cornea (HP:0007720)0.95780515
192Generalized tonic-clonic seizures (HP:0002069)0.95686180
193Distal lower limb amyotrophy (HP:0008944)0.94133951
194Absent speech (HP:0001344)0.93909949
195Atrial fibrillation (HP:0005110)0.92882717
196Exotropia (HP:0000577)0.92313380
197Cutaneous finger syndactyly (HP:0010554)0.91518318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK27.65157900
2NTRK36.99094466
3MST1R6.37442037
4GRK15.11455482
5EPHA43.19472124
6MET2.83294938
7NEK12.56535695
8BRSK22.42150413
9TTN2.41704000
10EEF2K2.14403276
11STK382.12135411
12NLK2.12101620
13EIF2AK12.02619515
14TNIK10.3184529
15NME21.91419301
16MAP3K141.84979414
17PRPF4B1.77197106
18MAP3K91.76474865
19PBK1.72486308
20MAPKAPK51.65894601
21MKNK11.63526690
22CAMKK21.57260343
23ACVR1B1.55278738
24NEK61.53002531
25RPS6KB21.49667154
26BUB11.48635920
27TLK11.48447175
28WNK41.46139502
29CDC71.45267418
30MAP2K71.39581461
31IRAK31.30872624
32ERBB41.29763035
33BRSK11.28871747
34FES1.27659744
35LATS21.22597531
36DAPK21.19224418
37PINK11.16149491
38BMPR21.14985129
39AURKB1.12093625
40MAPK131.10684909
41TAOK11.10676767
42WEE11.09230687
43MAP3K41.08312426
44CAMK11.02290288
45SIK21.02117870
46TSSK61.01343886
47CCNB10.99140286
48BRD40.98281205
49EIF2AK30.95990380
50MARK10.94571041
51MARK20.93454527
52CDK60.92840178
53RIPK10.92064412
54NEK20.91155002
55MAPK110.84998649
56PRKG20.84618252
57MAP3K70.84374897
58MAP2K20.84219883
59STK160.84175937
60CAMK40.83995514
61WNK10.81702347
62PIM20.80141896
63HIPK20.78996583
64ERBB20.78684072
65CAMK1G0.77804002
66CDK120.77520283
67CAMK2D0.77355190
68MAPK120.75475376
69SRPK10.74926332
70CAMK2A0.72142737
71MTOR0.71254036
72ADRBK10.70827096
73PAK40.70704760
74CSNK1D0.70116705
75PAK60.68792338
76CHEK20.67425077
77MAP2K10.67137260
78TESK10.66891712
79CDC42BPA0.66547354
80CASK0.66328921
81PLK10.65700804
82PDPK10.65439232
83INSRR0.65178771
84RPS6KA50.63078498
85ATR0.61474635
86TRIB30.61100286
87MAPK70.60794649
88TAOK30.60268007
89AURKA0.59741978
90CDK80.59241976
91TAOK20.59050969
92AKT30.58054652
93SGK10.58025431
94CAMK1D0.57861964
95EPHA20.57744700
96CDK50.56117129
97IRAK20.55054907
98CDK70.54626882
99SGK2230.54425807
100SGK4940.54425807
101TTK0.52830497
102SIK10.51181245
103DAPK10.51162714
104PRKCH0.50984426
105CDK40.48884159
106PRKCG0.48625575
107SGK20.47822559
108MINK10.47788544
109PRKCB0.47740500
110MELK0.45466674
111PIM10.44993999
112SCYL20.43693676
113PAK20.43471540
114NEK90.43090698
115MAP3K80.42651605
116FER0.42513446
117PRKD30.42457513
118ERN10.41863822
119ABL20.41645858
120EIF2AK20.41350776
121SMG10.41062498
122MAP3K120.41052612
123PRKCQ0.40081840
124PHKG10.39422099
125PHKG20.39422099
126GRK50.39290153
127CHEK10.38987051
128RPS6KA30.38967491
129STK390.38872708
130MAP3K130.38413110
131DYRK1A0.38176796
132PLK20.36747042
133MAPKAPK30.36243757
134MAPK40.36041576
135NTRK20.35952484
136CAMK2G0.35720645
137CAMKK10.35618976
138YES10.34913438
139BMX0.34786246
140CDK10.34642263
141NME10.34575612
142MAP2K40.34220054
143JAK10.33419388
144PKN10.33206500
145BRAF0.32949537
146PRKACG0.32865116
147CAMK2B0.32630700
148MAP3K10.32591094
149LATS10.32267994
150ERBB30.32048760
151PNCK0.31967620
152SGK30.31960343
153PRKAA10.31298974
154AKT20.31041127
155CDK20.30834211
156RAF10.30710029
157PTK20.30676550
158GSK3B0.29710594
159ZAK0.29056970
160FGFR10.27875822
161PRKCZ0.27767870
162RPS6KB10.27303655
163TRPM70.27210831
164PRKD20.26923745
165KSR20.26132855
166ICK0.26111300
167PRKG10.25795859
168PRKCA0.23282440
169MYLK0.23132268
170PAK30.23089321
171PRKD10.22304736
172STK110.21911300
173PRKAA20.21366384
174PRKDC0.21168778
175FYN0.20791920
176CSNK1E0.20694436
177OXSR10.20585737

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.83955646
2DNA replication_Homo sapiens_hsa030303.07076110
3Biosynthesis of amino acids_Homo sapiens_hsa012303.06003355
4Folate biosynthesis_Homo sapiens_hsa007902.72932850
5Pyruvate metabolism_Homo sapiens_hsa006202.63874669
6Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.38755390
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25254012
8Carbon metabolism_Homo sapiens_hsa012002.10049745
9Mismatch repair_Homo sapiens_hsa034302.00489835
10Phototransduction_Homo sapiens_hsa0474413.7968817
11Pentose phosphate pathway_Homo sapiens_hsa000301.95611394
12Fatty acid biosynthesis_Homo sapiens_hsa000611.92602213
13Synaptic vesicle cycle_Homo sapiens_hsa047211.87838704
14Vitamin B6 metabolism_Homo sapiens_hsa007501.84345467
15Non-homologous end-joining_Homo sapiens_hsa034501.83848570
16Nicotine addiction_Homo sapiens_hsa050331.79429603
17Galactose metabolism_Homo sapiens_hsa000521.74003588
18Selenocompound metabolism_Homo sapiens_hsa004501.73614136
19Phenylalanine metabolism_Homo sapiens_hsa003601.68842925
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.65218330
21Sulfur relay system_Homo sapiens_hsa041221.64449662
22Olfactory transduction_Homo sapiens_hsa047401.63670545
23GABAergic synapse_Homo sapiens_hsa047271.63368984
24Glutamatergic synapse_Homo sapiens_hsa047241.55402405
25Cell cycle_Homo sapiens_hsa041101.54022323
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49977218
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47617459
28Systemic lupus erythematosus_Homo sapiens_hsa053221.47253325
29Nucleotide excision repair_Homo sapiens_hsa034201.47214692
30Circadian entrainment_Homo sapiens_hsa047131.43243629
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39769505
32Small cell lung cancer_Homo sapiens_hsa052221.39658214
33Morphine addiction_Homo sapiens_hsa050321.35311814
34Fatty acid degradation_Homo sapiens_hsa000711.27979511
35PPAR signaling pathway_Homo sapiens_hsa033201.17753093
36Fatty acid metabolism_Homo sapiens_hsa012121.16387820
37Cholinergic synapse_Homo sapiens_hsa047251.16229323
38Sulfur metabolism_Homo sapiens_hsa009201.16194822
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.15386196
40Long-term potentiation_Homo sapiens_hsa047201.14412521
41Renin-angiotensin system_Homo sapiens_hsa046141.14302810
42Dopaminergic synapse_Homo sapiens_hsa047281.09857091
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08518985
44Circadian rhythm_Homo sapiens_hsa047101.07171170
45RNA transport_Homo sapiens_hsa030131.06727390
46Vitamin digestion and absorption_Homo sapiens_hsa049771.03324213
47Amphetamine addiction_Homo sapiens_hsa050311.02078706
48Insulin secretion_Homo sapiens_hsa049111.01851337
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.01476829
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00325634
51Glutathione metabolism_Homo sapiens_hsa004800.97934976
52One carbon pool by folate_Homo sapiens_hsa006700.95488357
53N-Glycan biosynthesis_Homo sapiens_hsa005100.95119660
54Fat digestion and absorption_Homo sapiens_hsa049750.92122950
55Histidine metabolism_Homo sapiens_hsa003400.91598473
56Serotonergic synapse_Homo sapiens_hsa047260.90836159
57Renin secretion_Homo sapiens_hsa049240.90334387
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.89272350
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88989883
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88735855
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87115754
62Oxytocin signaling pathway_Homo sapiens_hsa049210.86465127
63Tryptophan metabolism_Homo sapiens_hsa003800.85500526
64Ovarian steroidogenesis_Homo sapiens_hsa049130.84027762
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.83972097
66Nitrogen metabolism_Homo sapiens_hsa009100.82559537
67Pyrimidine metabolism_Homo sapiens_hsa002400.82549511
68Salivary secretion_Homo sapiens_hsa049700.82048239
69Propanoate metabolism_Homo sapiens_hsa006400.79930576
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78166071
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77867739
72Protein digestion and absorption_Homo sapiens_hsa049740.76094489
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75873410
74Taste transduction_Homo sapiens_hsa047420.74890661
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74809587
76ABC transporters_Homo sapiens_hsa020100.74556448
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74218467
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74100567
79Calcium signaling pathway_Homo sapiens_hsa040200.74065063
80Base excision repair_Homo sapiens_hsa034100.73554164
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73069019
82Fanconi anemia pathway_Homo sapiens_hsa034600.73028161
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72721448
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72417224
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72352831
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71805308
87beta-Alanine metabolism_Homo sapiens_hsa004100.71344361
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66396513
89Gastric acid secretion_Homo sapiens_hsa049710.64496905
90Dilated cardiomyopathy_Homo sapiens_hsa054140.64470806
91cAMP signaling pathway_Homo sapiens_hsa040240.64397287
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63828422
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61245483
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61186592
95Type II diabetes mellitus_Homo sapiens_hsa049300.59584250
96Viral carcinogenesis_Homo sapiens_hsa052030.59334411
97Caffeine metabolism_Homo sapiens_hsa002320.57276152
98VEGF signaling pathway_Homo sapiens_hsa043700.56616531
99Glioma_Homo sapiens_hsa052140.56293848
100Cocaine addiction_Homo sapiens_hsa050300.56267282
101Arginine and proline metabolism_Homo sapiens_hsa003300.55937821
102Arginine biosynthesis_Homo sapiens_hsa002200.55860569
103Tyrosine metabolism_Homo sapiens_hsa003500.55649066
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55267755
105ErbB signaling pathway_Homo sapiens_hsa040120.54407009
106Axon guidance_Homo sapiens_hsa043600.53621113
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52782881
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52133085
109Ribosome_Homo sapiens_hsa030100.51639423
110Starch and sucrose metabolism_Homo sapiens_hsa005000.50521669
111Lysine degradation_Homo sapiens_hsa003100.50280423
112Other glycan degradation_Homo sapiens_hsa005110.49117848
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48924749
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47550795
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.47235603
116Chemical carcinogenesis_Homo sapiens_hsa052040.44585875
117Retinol metabolism_Homo sapiens_hsa008300.44427541
118Homologous recombination_Homo sapiens_hsa034400.44215163
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.43029959
120GnRH signaling pathway_Homo sapiens_hsa049120.42419626
121Long-term depression_Homo sapiens_hsa047300.41954630
122Metabolic pathways_Homo sapiens_hsa011000.41224716
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41161688
124Adherens junction_Homo sapiens_hsa045200.39657603
125TGF-beta signaling pathway_Homo sapiens_hsa043500.38298589
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.38211856
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38103983
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38084760
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37825982
130Glycerolipid metabolism_Homo sapiens_hsa005610.37750319
131Bile secretion_Homo sapiens_hsa049760.37100267
132Thyroid hormone synthesis_Homo sapiens_hsa049180.35336510
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35161184
134Melanogenesis_Homo sapiens_hsa049160.34674835
135Mineral absorption_Homo sapiens_hsa049780.34588436
136Ras signaling pathway_Homo sapiens_hsa040140.34241104
137* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33995111
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.33387848
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33324227
140Spliceosome_Homo sapiens_hsa030400.33229984
141Estrogen signaling pathway_Homo sapiens_hsa049150.33115867
142Glucagon signaling pathway_Homo sapiens_hsa049220.32780652
143Chemokine signaling pathway_Homo sapiens_hsa040620.32441527
144Choline metabolism in cancer_Homo sapiens_hsa052310.32058049
145Pancreatic secretion_Homo sapiens_hsa049720.31295935
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30564110
147Wnt signaling pathway_Homo sapiens_hsa043100.29284477
148Collecting duct acid secretion_Homo sapiens_hsa049660.29235808
149Endometrial cancer_Homo sapiens_hsa052130.29182593
150Cardiac muscle contraction_Homo sapiens_hsa042600.29108152
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28985335
152Hippo signaling pathway_Homo sapiens_hsa043900.28745144
153Complement and coagulation cascades_Homo sapiens_hsa046100.28211784
154Bladder cancer_Homo sapiens_hsa052190.26127536
155MAPK signaling pathway_Homo sapiens_hsa040100.25685196
156Alcoholism_Homo sapiens_hsa050340.25281569
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25268911
158Adipocytokine signaling pathway_Homo sapiens_hsa049200.25161031
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22793714
160Fatty acid elongation_Homo sapiens_hsa000620.22421195
161Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22100591
162Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21387207
163Inositol phosphate metabolism_Homo sapiens_hsa005620.21035463
164Thyroid cancer_Homo sapiens_hsa052160.21019778
165Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19485373
166Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18373082
167Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17065699
168mTOR signaling pathway_Homo sapiens_hsa041500.16464538
169Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16036455
170Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14307828
171Chronic myeloid leukemia_Homo sapiens_hsa052200.13580741
172SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13464239
173Ether lipid metabolism_Homo sapiens_hsa005650.12091155
174ECM-receptor interaction_Homo sapiens_hsa045120.11737899
175Fructose and mannose metabolism_Homo sapiens_hsa000510.11033413
176Purine metabolism_Homo sapiens_hsa002300.11011317
177B cell receptor signaling pathway_Homo sapiens_hsa046620.08439017

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »