GLRA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.64792882
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.29978324
3synaptic vesicle maturation (GO:0016188)5.86234776
4synaptic vesicle exocytosis (GO:0016079)5.24054975
5cellular potassium ion homeostasis (GO:0030007)5.21877434
6* positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.10964830
7neurotransmitter secretion (GO:0007269)5.07851415
8* neuromuscular process controlling posture (GO:0050884)5.03783257
9regulation of hexokinase activity (GO:1903299)4.90315808
10regulation of glucokinase activity (GO:0033131)4.90315808
11neurotransmitter uptake (GO:0001504)4.83350734
12neurotransmitter transport (GO:0006836)4.68604594
13respiratory chain complex IV assembly (GO:0008535)4.66022573
14regulation of synaptic vesicle exocytosis (GO:2000300)4.65724754
15cerebellar Purkinje cell differentiation (GO:0021702)4.65083951
16sodium ion export (GO:0071436)4.63957059
17vocalization behavior (GO:0071625)4.51887394
18glutamate secretion (GO:0014047)4.51830054
19neuronal action potential propagation (GO:0019227)4.50508921
20protein localization to synapse (GO:0035418)4.38025943
21serotonin metabolic process (GO:0042428)4.32626584
22regulation of neurotransmitter levels (GO:0001505)4.24438186
23regulation of synaptic vesicle transport (GO:1902803)4.19315733
24neuron cell-cell adhesion (GO:0007158)4.17646493
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.16698124
26glycine transport (GO:0015816)4.14384461
27neurotransmitter catabolic process (GO:0042135)4.11879687
28cellular ketone body metabolic process (GO:0046950)4.11814153
29cytochrome complex assembly (GO:0017004)4.09412911
30* regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07296011
31potassium ion homeostasis (GO:0055075)4.06356143
32ketone body metabolic process (GO:1902224)4.00645515
33water-soluble vitamin biosynthetic process (GO:0042364)3.97739453
34* regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.95404063
35positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.93349226
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93198445
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.89627335
38regulation of glutamate receptor signaling pathway (GO:1900449)3.88385660
39locomotory exploration behavior (GO:0035641)3.87512756
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.86047491
41positive regulation of glycolytic process (GO:0045821)3.85883646
42DNA deamination (GO:0045006)3.85786329
43gamma-aminobutyric acid transport (GO:0015812)3.82552334
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.81235747
45exploration behavior (GO:0035640)3.81181155
46regulation of vesicle fusion (GO:0031338)3.80950382
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.79159219
48synaptic vesicle endocytosis (GO:0048488)3.78981480
49cell communication by electrical coupling (GO:0010644)3.73815979
50glycerophospholipid catabolic process (GO:0046475)3.73593710
51signal peptide processing (GO:0006465)3.73336252
52potassium ion import (GO:0010107)3.71206546
53lactate metabolic process (GO:0006089)3.70940246
54prenylation (GO:0097354)3.69376046
55protein prenylation (GO:0018342)3.69376046
56primary amino compound metabolic process (GO:1901160)3.68828408
57response to histamine (GO:0034776)3.65786204
58transmission of nerve impulse (GO:0019226)3.63401341
59protein complex biogenesis (GO:0070271)3.59519514
60regulation of type B pancreatic cell apoptotic process (GO:2000674)3.59185702
61regulation of neuronal synaptic plasticity (GO:0048168)3.56933376
62neurofilament cytoskeleton organization (GO:0060052)3.56344458
63ionotropic glutamate receptor signaling pathway (GO:0035235)3.54219943
64protein K11-linked deubiquitination (GO:0035871)3.52534470
65protein localization to cilium (GO:0061512)3.51813844
66regulation of catecholamine metabolic process (GO:0042069)3.51148714
67regulation of dopamine metabolic process (GO:0042053)3.51148714
68synaptic vesicle docking involved in exocytosis (GO:0016081)3.45941620
69negative regulation of cytosolic calcium ion concentration (GO:0051481)3.42707063
70* regulation of respiratory system process (GO:0044065)3.41937048
71negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41862549
72neuron recognition (GO:0008038)3.40740006
73regulation of long-term neuronal synaptic plasticity (GO:0048169)3.37657057
74synaptic transmission, glutamatergic (GO:0035249)3.34896473
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.34552201
76long-term memory (GO:0007616)3.32934171
77glutamate receptor signaling pathway (GO:0007215)3.32858125
78positive regulation of potassium ion transmembrane transport (GO:1901381)3.31721096
79* membrane hyperpolarization (GO:0060081)3.31517809
80cellular sodium ion homeostasis (GO:0006883)3.31512168
81endocrine pancreas development (GO:0031018)3.31225584
82L-amino acid import (GO:0043092)3.30959400
83* neuron-neuron synaptic transmission (GO:0007270)3.30936312
84platelet dense granule organization (GO:0060155)3.30545914
85axon cargo transport (GO:0008088)3.29429986
86proline transport (GO:0015824)3.27347126
87activation of protein kinase A activity (GO:0034199)3.26976515
88gamma-aminobutyric acid signaling pathway (GO:0007214)3.23567640
89layer formation in cerebral cortex (GO:0021819)3.23378806
90nitric oxide mediated signal transduction (GO:0007263)3.19727403
91insulin secretion (GO:0030073)3.19611802
92inositol phosphate catabolic process (GO:0071545)3.19273177
93mitochondrial respiratory chain complex assembly (GO:0033108)3.18671376
94neuromuscular synaptic transmission (GO:0007274)3.17857962
95polyol catabolic process (GO:0046174)3.16927019
96behavioral response to nicotine (GO:0035095)3.15065169
97dopamine transport (GO:0015872)3.14960340
98L-fucose catabolic process (GO:0042355)3.11690519
99fucose catabolic process (GO:0019317)3.11690519
100L-fucose metabolic process (GO:0042354)3.11690519
101nonmotile primary cilium assembly (GO:0035058)3.11637345
102cAMP-mediated signaling (GO:0019933)3.11491713
103establishment of synaptic vesicle localization (GO:0097480)3.10323433
104synaptic vesicle transport (GO:0048489)3.10323433
105behavioral defense response (GO:0002209)3.08694020
106behavioral fear response (GO:0001662)3.08694020
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07576120
108regulation of synaptic transmission, dopaminergic (GO:0032225)3.05772278
109keratinocyte development (GO:0003334)3.05555688
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04595784
111mitochondrial respiratory chain complex I assembly (GO:0032981)3.04595784
112NADH dehydrogenase complex assembly (GO:0010257)3.04595784
113regulation of neurotransmitter secretion (GO:0046928)3.02662095
114mating behavior (GO:0007617)3.02639399
115negative regulation of acute inflammatory response (GO:0002674)3.02270532
116* adult walking behavior (GO:0007628)3.01999208
117central nervous system myelination (GO:0022010)3.00546051
118axon ensheathment in central nervous system (GO:0032291)3.00546051
119membrane depolarization during action potential (GO:0086010)2.99912962
120preassembly of GPI anchor in ER membrane (GO:0016254)2.98712396
121* startle response (GO:0001964)2.97687624
122cell differentiation in hindbrain (GO:0021533)2.97219888
123presynaptic membrane assembly (GO:0097105)2.96633698
124negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95475398
125axoneme assembly (GO:0035082)2.95471334
126positive regulation of respiratory burst (GO:0060267)2.94409466
127regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93623571
128dendritic spine morphogenesis (GO:0060997)2.93024029
129* regulation of respiratory gaseous exchange (GO:0043576)2.92929603
130response to auditory stimulus (GO:0010996)2.92720557
131regulation of cilium movement (GO:0003352)2.92081002
132postsynaptic membrane organization (GO:0001941)2.91222681
133positive regulation of insulin secretion (GO:0032024)2.90924451
134positive regulation of peptide hormone secretion (GO:0090277)2.89961917
135presynaptic membrane organization (GO:0097090)2.89730679
136* regulation of postsynaptic membrane potential (GO:0060078)2.89479224
137mannosylation (GO:0097502)2.89261529
138kidney morphogenesis (GO:0060993)2.88987730
139regulation of neurotransmitter transport (GO:0051588)2.88779934
140signal release (GO:0023061)2.88459590
141negative regulation of protein oligomerization (GO:0032460)2.87920701
142regulation of synaptic transmission, GABAergic (GO:0032228)2.87332354
143* synaptic transmission (GO:0007268)2.85123107
144protein K6-linked ubiquitination (GO:0085020)2.84408918
145synapse assembly (GO:0007416)2.82552126
146regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82517457
147membrane repolarization (GO:0086009)2.82434157
148phosphorylated carbohydrate dephosphorylation (GO:0046838)2.76254925
149inositol phosphate dephosphorylation (GO:0046855)2.76254925
150negative regulation of hormone biosynthetic process (GO:0032353)2.76044029
151positive regulation of peptide secretion (GO:0002793)2.75264126
152protein polyglutamylation (GO:0018095)2.73012003
153regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.70870019
154positive regulation of protein autophosphorylation (GO:0031954)2.69215439
155photoreceptor cell maintenance (GO:0045494)2.68887053
156indolalkylamine metabolic process (GO:0006586)2.66861331
157detection of light stimulus involved in visual perception (GO:0050908)2.65369602
158detection of light stimulus involved in sensory perception (GO:0050962)2.65369602
159cilium morphogenesis (GO:0060271)2.62779983
160amine catabolic process (GO:0009310)2.56309295
161cellular biogenic amine catabolic process (GO:0042402)2.56309295
162ATP hydrolysis coupled proton transport (GO:0015991)2.55231246
163energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.55231246
164tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53705965
165RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53705965
166retinal cone cell development (GO:0046549)2.52606701
167regulation of neurotransmitter uptake (GO:0051580)2.51157337
168negative regulation of telomere maintenance (GO:0032205)2.50989127
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50758262
170establishment of protein localization to Golgi (GO:0072600)2.48473119
171alanine transport (GO:0032328)2.48415740
172adaptation of signaling pathway (GO:0023058)2.45838367
173indole-containing compound catabolic process (GO:0042436)2.44348360
174indolalkylamine catabolic process (GO:0046218)2.44348360
175tryptophan catabolic process (GO:0006569)2.44348360
176auditory receptor cell stereocilium organization (GO:0060088)2.43136583
177anterograde synaptic vesicle transport (GO:0048490)2.41120427
178protein-cofactor linkage (GO:0018065)2.41027669
179negative regulation of gluconeogenesis (GO:0045721)2.38452868
180cilium organization (GO:0044782)2.37226315
181branched-chain amino acid catabolic process (GO:0009083)2.36825864
182protein localization to Golgi apparatus (GO:0034067)2.36632489
183C-terminal protein amino acid modification (GO:0018410)2.35839410
184C-terminal protein lipidation (GO:0006501)2.35810102
185G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.35505024
186S-adenosylmethionine metabolic process (GO:0046500)2.35334729
187epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35208917
188piRNA metabolic process (GO:0034587)2.34203210
189fatty acid homeostasis (GO:0055089)2.34195516
190epithelial cilium movement (GO:0003351)2.34147954
191cilium assembly (GO:0042384)2.33299848
192regulation of insulin secretion (GO:0050796)2.32758990
193phasic smooth muscle contraction (GO:0014821)2.32383301
194serotonin receptor signaling pathway (GO:0007210)2.31855577
195kynurenine metabolic process (GO:0070189)2.30306050
196GPI anchor metabolic process (GO:0006505)2.29970420
197photoreceptor cell development (GO:0042461)2.29771121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.36696457
2GBX2_23144817_ChIP-Seq_PC3_Human4.06854163
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.22113645
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11292717
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01608472
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98834846
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85531944
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68183208
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68183208
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.64502361
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54397408
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.52916872
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50710047
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.47281666
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46981506
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41438279
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38953335
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37642230
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.33347390
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31119904
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28594040
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.26220870
23FUS_26573619_Chip-Seq_HEK293_Human2.19009786
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.17873072
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16399372
26AR_21572438_ChIP-Seq_LNCaP_Human2.14141276
27* REST_18959480_ChIP-ChIP_MESCs_Mouse2.12169378
28* DROSHA_22980978_ChIP-Seq_HELA_Human2.10327427
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10187142
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08137685
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04988368
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98621373
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.98381763
34ZNF274_21170338_ChIP-Seq_K562_Hela1.93626834
35EWS_26573619_Chip-Seq_HEK293_Human1.90294492
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.89968692
37TAF15_26573619_Chip-Seq_HEK293_Human1.88992343
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85538308
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82600991
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.78293124
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74664270
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72536429
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72295985
44IGF1R_20145208_ChIP-Seq_DFB_Human1.68520992
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66665671
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.66561181
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59720483
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58339281
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.56854574
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56743473
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55825301
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55694359
53* P300_19829295_ChIP-Seq_ESCs_Human1.54792580
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54371941
55TP53_22573176_ChIP-Seq_HFKS_Human1.53437868
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.52637368
57CBP_20019798_ChIP-Seq_JUKART_Human1.52592551
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52592551
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.51427576
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.51149299
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46001718
62RNF2_27304074_Chip-Seq_NSC_Mouse1.44717150
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.43263911
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42845685
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.42363685
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39873330
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38553337
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37494533
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37237870
70TCF4_22108803_ChIP-Seq_LS180_Human1.37236819
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36540286
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35752641
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34473239
74STAT3_23295773_ChIP-Seq_U87_Human1.33783181
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.33645824
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32771626
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30378119
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29706769
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29643788
80MYC_18940864_ChIP-ChIP_HL60_Human1.29376965
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.28666569
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27811966
83NANOG_19829295_ChIP-Seq_ESCs_Human1.27288957
84SOX2_19829295_ChIP-Seq_ESCs_Human1.27288957
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.27114557
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25583264
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.25225476
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24979598
89AR_25329375_ChIP-Seq_VCAP_Human1.24887478
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23266488
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23232270
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.22405079
93P53_22387025_ChIP-Seq_ESCs_Mouse1.21825065
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.21037005
95* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20223757
96ER_23166858_ChIP-Seq_MCF-7_Human1.19182035
97VDR_23849224_ChIP-Seq_CD4+_Human1.19075116
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.18988192
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18957820
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18930050
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.18930050
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.18275314
103NCOR_22424771_ChIP-Seq_293T_Human1.17277466
104AR_19668381_ChIP-Seq_PC3_Human1.17135814
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16819632
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15641860
107CDX2_22108803_ChIP-Seq_LS180_Human1.15526352
108* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15174047
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15158277
110* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13774790
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12625764
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11336285
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11300575
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11183752
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10079157
116* FLI1_21867929_ChIP-Seq_TH2_Mouse1.09110136
117* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09050636
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.08043050
119* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07696329
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.07091880
121P300_18555785_Chip-Seq_ESCs_Mouse1.06544541
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06114315
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05999315
124TBL1_22424771_ChIP-Seq_293T_Human1.05363698
125GATA3_21878914_ChIP-Seq_MCF-7_Human1.04565878
126SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03903404
127HTT_18923047_ChIP-ChIP_STHdh_Human1.03778070
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03714252
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03297514
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03115233
131PHF8_20622853_ChIP-Seq_HELA_Human1.02835028
132RUNX2_22187159_ChIP-Seq_PCA_Human1.02443838
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02049926
134* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00687577
135TCF4_23295773_ChIP-Seq_U87_Human0.99724791
136RING1B_27294783_Chip-Seq_NPCs_Mouse0.98374249
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97356747
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97344956
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96814259
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96573874
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96166599
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.95794412
143CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95144792
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.93524382
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.92510775
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91330050
147AHR_22903824_ChIP-Seq_MCF-7_Human0.91310777
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.89142404
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.89101997
150SMAD3_21741376_ChIP-Seq_ESCs_Human0.86236000
151* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86032506
152ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84495675
153ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84179896
154CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83201672
155JUN_21703547_ChIP-Seq_K562_Human0.82865271
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.81745987
157KDM2B_26808549_Chip-Seq_REH_Human0.81731295
158VDR_22108803_ChIP-Seq_LS180_Human0.81425539
159BCAT_22108803_ChIP-Seq_LS180_Human0.81143186
160TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80560695
161RXR_22108803_ChIP-Seq_LS180_Human0.79757692
162TP53_20018659_ChIP-ChIP_R1E_Mouse0.79572877

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.10857723
2MP0002102_abnormal_ear_morphology4.34752472
3MP0005423_abnormal_somatic_nervous4.19678415
4MP0004859_abnormal_synaptic_plasticity4.04777424
5MP0003195_calcinosis4.04481451
6MP0006276_abnormal_autonomic_nervous3.68555693
7* MP0003635_abnormal_synaptic_transmissio3.52059269
8MP0001501_abnormal_sleep_pattern3.49618230
9MP0003122_maternal_imprinting3.20120951
10* MP0009046_muscle_twitch3.11344159
11* MP0002064_seizures3.11222739
12MP0009745_abnormal_behavioral_response2.98619031
13MP0004270_analgesia2.86214952
14MP0008877_abnormal_DNA_methylation2.80586780
15* MP0002272_abnormal_nervous_system2.78371323
16MP0002572_abnormal_emotion/affect_behav2.60970573
17MP0002063_abnormal_learning/memory/cond2.59823085
18MP0002163_abnormal_gland_morphology2.53651310
19* MP0001486_abnormal_startle_reflex2.49788033
20MP0001968_abnormal_touch/_nociception2.48430580
21* MP0004142_abnormal_muscle_tone2.36269405
22MP0001440_abnormal_grooming_behavior2.34775261
23MP0005379_endocrine/exocrine_gland_phen2.30071833
24MP0001529_abnormal_vocalization2.26447122
25MP0002734_abnormal_mechanical_nocicepti2.24962823
26MP0000372_irregular_coat_pigmentation2.24823623
27* MP0002067_abnormal_sensory_capabilities2.03342296
28MP0002733_abnormal_thermal_nociception1.99904927
29MP0000569_abnormal_digit_pigmentation1.99409779
30* MP0005551_abnormal_eye_electrophysiolog1.98556551
31MP0004885_abnormal_endolymph1.90359799
32MP0003123_paternal_imprinting1.88043503
33MP0001986_abnormal_taste_sensitivity1.84907752
34MP0002184_abnormal_innervation1.84628462
35MP0002693_abnormal_pancreas_physiology1.84052506
36MP0002736_abnormal_nociception_after1.83316401
37MP0001970_abnormal_pain_threshold1.82940397
38MP0004043_abnormal_pH_regulation1.81790834
39* MP0004924_abnormal_behavior1.79780599
40* MP0005386_behavior/neurological_phenoty1.79780599
41MP0002557_abnormal_social/conspecific_i1.79296243
42MP0005646_abnormal_pituitary_gland1.78426027
43MP0008875_abnormal_xenobiotic_pharmacok1.74517802
44MP0002938_white_spotting1.69389254
45MP0005645_abnormal_hypothalamus_physiol1.67798983
46MP0002735_abnormal_chemical_nociception1.66574692
47MP0010386_abnormal_urinary_bladder1.65934630
48MP0008569_lethality_at_weaning1.65863899
49MP0003787_abnormal_imprinting1.65396507
50MP0003329_amyloid_beta_deposits1.65276481
51MP0000015_abnormal_ear_pigmentation1.61637478
52MP0005075_abnormal_melanosome_morpholog1.59332188
53MP0000778_abnormal_nervous_system1.57235274
54MP0000955_abnormal_spinal_cord1.56068917
55* MP0002882_abnormal_neuron_morphology1.52579610
56MP0002928_abnormal_bile_duct1.52240240
57MP0002909_abnormal_adrenal_gland1.51469649
58MP0002254_reproductive_system_inflammat1.46171514
59MP0001905_abnormal_dopamine_level1.46041920
60MP0001944_abnormal_pancreas_morphology1.42130719
61MP0000427_abnormal_hair_cycle1.41777186
62MP0002229_neurodegeneration1.41710044
63* MP0002066_abnormal_motor_capabilities/c1.41577802
64MP0005670_abnormal_white_adipose1.40573879
65MP0004811_abnormal_neuron_physiology1.40072991
66MP0005174_abnormal_tail_pigmentation1.39283035
67MP0006072_abnormal_retinal_apoptosis1.36736747
68MP0001984_abnormal_olfaction1.31282028
69MP0004145_abnormal_muscle_electrophysio1.30600726
70MP0003690_abnormal_glial_cell1.28664172
71MP0003121_genomic_imprinting1.23247511
72MP0001502_abnormal_circadian_rhythm1.21912987
73MP0005253_abnormal_eye_physiology1.21203951
74MP0003183_abnormal_peptide_metabolism1.20875430
75MP0001188_hyperpigmentation1.14425475
76MP0002138_abnormal_hepatobiliary_system1.13552068
77MP0005535_abnormal_body_temperature1.13021894
78MP0003633_abnormal_nervous_system1.11420552
79MP0003879_abnormal_hair_cell1.09469647
80MP0005332_abnormal_amino_acid1.06108987
81MP0000920_abnormal_myelination1.05363427
82MP0001756_abnormal_urination1.04497944
83MP0006036_abnormal_mitochondrial_physio1.04253258
84MP0002752_abnormal_somatic_nervous1.03762735
85MP0005220_abnormal_exocrine_pancreas1.03746026
86MP0003634_abnormal_glial_cell1.03133030
87MP0004742_abnormal_vestibular_system1.02570827
88MP0004133_heterotaxia1.01729237
89MP0000383_abnormal_hair_follicle1.01703314
90MP0005389_reproductive_system_phenotype1.00593885
91MP0003011_delayed_dark_adaptation0.99933757
92MP0002078_abnormal_glucose_homeostasis0.99596066
93MP0003136_yellow_coat_color0.99529326
94MP0000751_myopathy0.99460104
95MP0008058_abnormal_DNA_repair0.98720594
96MP0005636_abnormal_mineral_homeostasis0.97333948
97MP0002095_abnormal_skin_pigmentation0.97039390
98MP0002152_abnormal_brain_morphology0.96972970
99MP0005084_abnormal_gallbladder_morpholo0.96537223
100MP0008057_abnormal_DNA_replication0.96256118
101MP0003283_abnormal_digestive_organ0.95742365
102MP0003631_nervous_system_phenotype0.95727638
103MP0002160_abnormal_reproductive_system0.95257728
104MP0001764_abnormal_homeostasis0.95100431
105MP0004858_abnormal_nervous_system0.94293722
106MP0004085_abnormal_heartbeat0.91819900
107MP0002837_dystrophic_cardiac_calcinosis0.91133770
108MP0001963_abnormal_hearing_physiology0.89819066
109MP0005623_abnormal_meninges_morphology0.88911176
110MP0003718_maternal_effect0.87080666
111MP0001485_abnormal_pinna_reflex0.85388004
112MP0003252_abnormal_bile_duct0.85130628
113MP0003786_premature_aging0.85059330
114MP0009780_abnormal_chondrocyte_physiolo0.83228952
115MP0010678_abnormal_skin_adnexa0.83000173
116MP0004147_increased_porphyrin_level0.81578563
117MP0001324_abnormal_eye_pigmentation0.81101546
118MP0005448_abnormal_energy_balance0.79607810
119MP0003632_abnormal_nervous_system0.79143952
120MP0002177_abnormal_outer_ear0.78609247
121MP0000631_abnormal_neuroendocrine_gland0.78236736
122MP0008961_abnormal_basal_metabolism0.77248717
123MP0002638_abnormal_pupillary_reflex0.76454977
124MP0000613_abnormal_salivary_gland0.76123530
125MP0006292_abnormal_olfactory_placode0.75828694
126MP0005310_abnormal_salivary_gland0.75769449
127MP0005408_hypopigmentation0.75272767
128MP0010329_abnormal_lipoprotein_level0.75232687
129MP0003953_abnormal_hormone_level0.74994123
130* MP0001943_abnormal_respiration0.73828127
131MP0002090_abnormal_vision0.73206367
132MP0002069_abnormal_eating/drinking_beha0.72871079
133MP0004215_abnormal_myocardial_fiber0.72495016
134MP0001177_atelectasis0.72468260
135MP0002332_abnormal_exercise_endurance0.72278366
136MP0000604_amyloidosis0.67413957
137MP0003172_abnormal_lysosome_physiology0.66906395
138MP0003137_abnormal_impulse_conducting0.66899779
139MP0002876_abnormal_thyroid_physiology0.60420538
140MP0008775_abnormal_heart_ventricle0.59920994
141* MP0002082_postnatal_lethality0.59557728
142* MP0010770_preweaning_lethality0.59557728
143MP0001299_abnormal_eye_distance/0.59449291
144MP0000013_abnormal_adipose_tissue0.58942856
145* MP0010769_abnormal_survival0.58390825
146MP0008874_decreased_physiological_sensi0.58017038
147MP0005195_abnormal_posterior_eye0.57503884
148MP0002822_catalepsy0.57123586
149MP0000026_abnormal_inner_ear0.56909306
150MP0000747_muscle_weakness0.56536641
151MP0008872_abnormal_physiological_respon0.54756309
152* MP0010768_mortality/aging0.54588502
153* MP0005410_abnormal_fertilization0.53585088

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.94759868
2Focal seizures (HP:0007359)5.08032480
3Supranuclear gaze palsy (HP:0000605)5.02918772
4Myokymia (HP:0002411)4.95327992
5Progressive cerebellar ataxia (HP:0002073)4.71139200
6Visual hallucinations (HP:0002367)4.66241135
7Hypoglycemic seizures (HP:0002173)4.65021396
8Hyperinsulinemic hypoglycemia (HP:0000825)4.38017886
9Generalized tonic-clonic seizures (HP:0002069)4.33740271
10Absence seizures (HP:0002121)4.19906668
11Febrile seizures (HP:0002373)4.14370577
12Ketoacidosis (HP:0001993)4.09277279
13Large for gestational age (HP:0001520)4.06780283
14Hypoglycemic coma (HP:0001325)3.93722600
15Atonic seizures (HP:0010819)3.66745815
16Epileptic encephalopathy (HP:0200134)3.66228595
17Dialeptic seizures (HP:0011146)3.65083470
18Pancreatic cysts (HP:0001737)3.57769079
19Congenital stationary night blindness (HP:0007642)3.55681845
20Truncal ataxia (HP:0002078)3.55493094
21Ankle clonus (HP:0011448)3.54227245
22Pancreatic fibrosis (HP:0100732)3.50781868
23True hermaphroditism (HP:0010459)3.37135777
24Hypomagnesemia (HP:0002917)3.17029293
25Abnormal drinking behavior (HP:0030082)3.16984059
26Polydipsia (HP:0001959)3.16984059
27Abnormality of midbrain morphology (HP:0002418)3.16926744
28Molar tooth sign on MRI (HP:0002419)3.16926744
29Hyperglycemia (HP:0003074)3.14836386
30Abnormality of the pancreatic islet cells (HP:0006476)3.14426165
31Abnormality of endocrine pancreas physiology (HP:0012093)3.14426165
32Pheochromocytoma (HP:0002666)3.13477980
33Prominent metopic ridge (HP:0005487)3.10775333
34Mutism (HP:0002300)3.10403018
35Hemiparesis (HP:0001269)3.09257486
36Urinary bladder sphincter dysfunction (HP:0002839)3.04587579
37Abnormality of the renal cortex (HP:0011035)3.03825700
38Medial flaring of the eyebrow (HP:0010747)3.03301239
39Broad-based gait (HP:0002136)3.02070635
40Abnormality of binocular vision (HP:0011514)3.00627920
41Diplopia (HP:0000651)3.00627920
42Abnormality of the metopic suture (HP:0005556)2.98813343
43Symptomatic seizures (HP:0011145)2.98132424
44Hemiplegia (HP:0002301)2.97481787
45Action tremor (HP:0002345)2.94011535
46Postural instability (HP:0002172)2.92941383
47Abnormal eating behavior (HP:0100738)2.92205908
48Nephronophthisis (HP:0000090)2.91235484
49Spastic gait (HP:0002064)2.89608668
50Dysmetria (HP:0001310)2.88039844
51Ketosis (HP:0001946)2.85536167
52Dysdiadochokinesis (HP:0002075)2.81722251
53Agitation (HP:0000713)2.80550109
54Hepatic necrosis (HP:0002605)2.78853946
55Pancreatic islet-cell hyperplasia (HP:0004510)2.78753866
56Depression (HP:0000716)2.76419172
57Anxiety (HP:0000739)2.76292605
58Neoplasm of the adrenal cortex (HP:0100641)2.75191901
59Gaze-evoked nystagmus (HP:0000640)2.72432967
60Urinary urgency (HP:0000012)2.70491179
61Genetic anticipation (HP:0003743)2.70398275
62Abnormality of the renal medulla (HP:0100957)2.69175955
63Mitochondrial inheritance (HP:0001427)2.68735575
64Hypothermia (HP:0002045)2.66043331
65Progressive macrocephaly (HP:0004481)2.65406649
66Acute necrotizing encephalopathy (HP:0006965)2.64298666
67Neuroendocrine neoplasm (HP:0100634)2.62312686
68Central scotoma (HP:0000603)2.62187303
69Increased CSF lactate (HP:0002490)2.60823910
70Drooling (HP:0002307)2.60500464
71Excessive salivation (HP:0003781)2.60500464
72Hepatocellular necrosis (HP:0001404)2.59151674
73Attenuation of retinal blood vessels (HP:0007843)2.57600845
74Insulin-resistant diabetes mellitus (HP:0000831)2.57066241
75Polyuria (HP:0000103)2.54435755
76Status epilepticus (HP:0002133)2.50303651
77Gait imbalance (HP:0002141)2.49821451
78Scanning speech (HP:0002168)2.49580630
79Tubular atrophy (HP:0000092)2.49246798
80Slow saccadic eye movements (HP:0000514)2.48956178
81Hyperventilation (HP:0002883)2.48100002
82Congenital primary aphakia (HP:0007707)2.46868315
83Neurofibrillary tangles (HP:0002185)2.44890134
84Lower limb muscle weakness (HP:0007340)2.44164446
85Abnormality of the corticospinal tract (HP:0002492)2.44061253
86Peripheral hypomyelination (HP:0007182)2.43234114
87Abnormality of magnesium homeostasis (HP:0004921)2.42295864
88Methylmalonic acidemia (HP:0002912)2.39837837
89Abnormality of macular pigmentation (HP:0008002)2.37843407
90Psychosis (HP:0000709)2.36877416
91Progressive inability to walk (HP:0002505)2.36251260
92Ventricular fibrillation (HP:0001663)2.34970702
93Papilledema (HP:0001085)2.34699200
94Acute encephalopathy (HP:0006846)2.34009289
95Increased circulating renin level (HP:0000848)2.33305716
96Polyphagia (HP:0002591)2.32713552
97Impaired vibration sensation in the lower limbs (HP:0002166)2.30370315
98Nephrogenic diabetes insipidus (HP:0009806)2.27113776
99Methylmalonic aciduria (HP:0012120)2.26682409
100Type II lissencephaly (HP:0007260)2.22748348
101Late onset (HP:0003584)2.21863196
102Muscle stiffness (HP:0003552)2.21583662
103Hyperthyroidism (HP:0000836)2.19924023
104Abnormal rod and cone electroretinograms (HP:0008323)2.18916952
105Intention tremor (HP:0002080)2.18905707
106Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18287107
107Cystic liver disease (HP:0006706)2.17991025
108Decreased central vision (HP:0007663)2.17150009
109Limb dystonia (HP:0002451)2.14760058
110Poor eye contact (HP:0000817)2.12387633
111Abnormal mitochondria in muscle tissue (HP:0008316)2.12312235
112Type I diabetes mellitus (HP:0100651)2.12200759
113Renal cortical cysts (HP:0000803)2.12030181
114Impaired social interactions (HP:0000735)2.11909281
115Abnormal social behavior (HP:0012433)2.11909281
116Abnormal pancreas size (HP:0012094)2.11717943
117Abnormality of saccadic eye movements (HP:0000570)2.10501556
118Fetal akinesia sequence (HP:0001989)2.10205351
119Tongue fasciculations (HP:0001308)2.09700055
120Degeneration of the lateral corticospinal tracts (HP:0002314)2.09265426
121Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09265426
122Clonus (HP:0002169)2.09028712
123Furrowed tongue (HP:0000221)2.07503346
124Prolonged QT interval (HP:0001657)2.07456786
125Hypoventilation (HP:0002791)2.06861255
126Abolished electroretinogram (ERG) (HP:0000550)2.06199274
127Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06132052
128Postural tremor (HP:0002174)2.05886757
129Bradykinesia (HP:0002067)2.05778654
130Tubulointerstitial nephritis (HP:0001970)2.02043628
131Impaired smooth pursuit (HP:0007772)2.00545862
132Aplasia/hypoplasia of the uterus (HP:0008684)2.00309580
133Abnormal EKG (HP:0003115)2.00195136
134Abnormality of vitamin B metabolism (HP:0004340)1.99701806
135Abnormality of ocular smooth pursuit (HP:0000617)1.99617904
136Intestinal atresia (HP:0011100)1.99467085
137Choreoathetosis (HP:0001266)1.98759909
138Abnormal urine output (HP:0012590)1.98740901
139Chronic hepatic failure (HP:0100626)1.97759837
140EEG with generalized epileptiform discharges (HP:0011198)1.97286499
141Torticollis (HP:0000473)1.94489776
142Male pseudohermaphroditism (HP:0000037)1.93126708
143Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92641278
144Lipid accumulation in hepatocytes (HP:0006561)1.92476289
145Specific learning disability (HP:0001328)1.92380392
146Epileptiform EEG discharges (HP:0011182)1.91409210
147Paraplegia (HP:0010550)1.91382266
148Metabolic alkalosis (HP:0200114)1.90369360
149Muscular hypotonia of the trunk (HP:0008936)1.90364680
150Generalized myoclonic seizures (HP:0002123)1.90256505
151Congenital sensorineural hearing impairment (HP:0008527)1.89880768
152Cerebral inclusion bodies (HP:0100314)1.89611314
153Aplasia/Hypoplasia of the fovea (HP:0008060)1.88588779
154Hypoplasia of the fovea (HP:0007750)1.88588779
155Gait ataxia (HP:0002066)1.88429391
156Genital tract atresia (HP:0001827)1.88241156
157Abnormal albumin level (HP:0012116)1.87909710
158Hypoalbuminemia (HP:0003073)1.87909710
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.87487422
160Absent speech (HP:0001344)1.87436381
161Unsteady gait (HP:0002317)1.86185151
162Insomnia (HP:0100785)1.86102511
163Blue irides (HP:0000635)1.84514777
164Increased hepatocellular lipid droplets (HP:0006565)1.83246035
165Clumsiness (HP:0002312)1.83010379
166Metaphyseal dysplasia (HP:0100255)1.81758167
167Poor suck (HP:0002033)1.81447759
168Congenital hepatic fibrosis (HP:0002612)1.81333354
169Esotropia (HP:0000565)1.80958498
170Pendular nystagmus (HP:0012043)1.80754497
171Stomatitis (HP:0010280)1.80127525
172Septo-optic dysplasia (HP:0100842)1.78742714
173Neuronal loss in central nervous system (HP:0002529)1.78044589
174Enlarged penis (HP:0000040)1.77146048
175Abnormality of renal excretion (HP:0011036)1.76626413
176Abnormality of the vocal cords (HP:0008777)1.76596636
177Severe muscular hypotonia (HP:0006829)1.76270014
178Vaginal atresia (HP:0000148)1.75623983
179Optic disc pallor (HP:0000543)1.74994957
180Rigidity (HP:0002063)1.74677318
181Hypsarrhythmia (HP:0002521)1.74213884
182Sclerocornea (HP:0000647)1.74086593
183Spastic paraplegia (HP:0001258)1.73536401
184Neoplasm of the adrenal gland (HP:0100631)1.72421442
185Scotoma (HP:0000575)1.72383228
186Anencephaly (HP:0002323)1.71127554
187CNS demyelination (HP:0007305)1.71087727
188Tachypnea (HP:0002789)1.70487093
189Thyroiditis (HP:0100646)1.69887842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.77295966
2NTRK35.09475113
3MAP4K23.94716870
4MAP3K123.84432481
5MAP3K43.36761834
6MARK13.29026412
7MINK13.16514483
8MAP2K72.57941542
9MAP2K42.46016090
10WNK12.33913927
11PAK62.28486920
12PNCK2.25786095
13UHMK12.12098037
14NTRK22.10538548
15MAP3K92.08088409
16ADRBK22.07911653
17TXK2.02782886
18ZAK2.00524099
19MST41.97285221
20STK381.81064755
21BMPR1B1.76867331
22CDK191.67045599
23EIF2AK31.66772888
24CASK1.65099065
25SIK31.63672865
26EIF2AK11.50037780
27WNK31.49151166
28MAPK131.45832821
29PAK31.45411378
30CAMK1G1.41484446
31TRIM281.39635694
32PASK1.38435089
33LIMK11.34751583
34STK38L1.32874870
35NUAK11.30268353
36FES1.30164590
37PLK21.28520108
38BCR1.28172904
39AKT31.24433435
40CAMK2A1.23147732
41PRKCG1.23144247
42NLK1.23069387
43OXSR11.22461360
44NTRK11.22445564
45LATS21.21874462
46CDK51.21361801
47INSRR1.19842871
48GRK51.16129622
49TNK21.14743022
50CAMKK11.14708976
51PHKG11.11261530
52PHKG21.11261530
53CSNK1G21.07982161
54GRK71.05587196
55STK391.05190897
56MAP2K61.05189113
57FGFR21.00591435
58SGK4941.00499247
59SGK2231.00499247
60TNIK0.98828225
61LMTK20.97352724
62STK160.95882901
63MKNK20.95725229
64CSNK1G30.95047900
65NEK10.94098624
66CAMK10.91510620
67PRKD30.89654337
68CDK140.89530285
69CAMK2G0.89308869
70PKN10.87828986
71PTK2B0.87609765
72CDC42BPA0.86896334
73CDK180.86851336
74BRSK20.84583599
75MUSK0.84230589
76CAMK2D0.81268231
77CAMK1D0.80893943
78ACVR1B0.80505581
79CDK150.80044949
80IRAK20.79961053
81TEC0.79453899
82STK110.78544470
83PLK30.78531167
84TSSK60.77641694
85PINK10.77030929
86CAMK2B0.77024758
87SIK20.76997275
88WNK40.76272573
89ROCK20.75619881
90PRKCH0.75385183
91CSNK1A1L0.72582549
92PRKCE0.72229887
93TAOK30.70631115
94CAMKK20.70425809
95STK30.70354700
96KSR10.68909366
97PDK20.68117174
98NEK60.67931025
99CDK11A0.66214810
100MAP3K110.65599267
101EPHA40.65597379
102SGK10.65497443
103MKNK10.65466171
104DYRK20.64607013
105PRKCZ0.64067085
106SGK20.61857364
107DAPK20.60740031
108TYRO30.60204486
109PRKAA20.59576473
110DAPK10.59511885
111MARK20.58787456
112BCKDK0.58525307
113MAPK100.56949946
114CSNK1G10.56560820
115DYRK1A0.54226329
116TAOK10.53781465
117RPS6KA30.53734962
118IRAK10.52772640
119IKBKB0.52332191
120PRKG10.52188384
121CSNK1E0.51063640
122TRPM70.50731960
123PRKCI0.49734642
124ROCK10.49572888
125CSNK1A10.48854429
126TIE10.47869270
127ERBB30.47735193
128TLK10.47419403
129PRKCQ0.47396086
130GRK10.44982765
131ADRBK10.43992146
132PRKCB0.43929110
133CSNK1D0.43729435
134PRKACA0.43087329
135MAP3K10.42878411
136VRK10.42837090
137RPS6KA50.42446754
138CDK30.42304678
139PRKAA10.42266388
140PRKD20.41613808
141FER0.40910193
142* PRKCA0.40461221
143MAP3K20.39951714
144SGK30.39387747
145MAPKAPK50.37469520
146PRKACB0.33717096
147ITK0.32614176
148ATM0.32342662
149MAP2K10.28997353
150HIPK20.27060592

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.81303915
2Nicotine addiction_Homo sapiens_hsa050334.05257748
3Synaptic vesicle cycle_Homo sapiens_hsa047213.78697244
4Protein export_Homo sapiens_hsa030603.29267820
5GABAergic synapse_Homo sapiens_hsa047273.13269225
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53691448
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53362411
8Serotonergic synapse_Homo sapiens_hsa047262.38234491
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33344801
10Morphine addiction_Homo sapiens_hsa050322.32276802
11Insulin secretion_Homo sapiens_hsa049112.26368117
12Olfactory transduction_Homo sapiens_hsa047402.20849596
13Circadian entrainment_Homo sapiens_hsa047132.18400830
14Glutamatergic synapse_Homo sapiens_hsa047242.12886372
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.10355137
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08069876
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02118291
18Regulation of autophagy_Homo sapiens_hsa041402.02060965
19Salivary secretion_Homo sapiens_hsa049701.95744424
20Taste transduction_Homo sapiens_hsa047421.90851578
21Dopaminergic synapse_Homo sapiens_hsa047281.89113015
22Proteasome_Homo sapiens_hsa030501.87558918
23Propanoate metabolism_Homo sapiens_hsa006401.87504292
24Amphetamine addiction_Homo sapiens_hsa050311.87357787
25Nitrogen metabolism_Homo sapiens_hsa009101.85878382
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75287439
27Cocaine addiction_Homo sapiens_hsa050301.74910956
28Cholinergic synapse_Homo sapiens_hsa047251.74009970
29Phototransduction_Homo sapiens_hsa047441.72111995
30Gastric acid secretion_Homo sapiens_hsa049711.71718613
31Cardiac muscle contraction_Homo sapiens_hsa042601.70930295
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68043939
33Renin secretion_Homo sapiens_hsa049241.66500122
34Selenocompound metabolism_Homo sapiens_hsa004501.66002397
35Long-term potentiation_Homo sapiens_hsa047201.59287761
36Collecting duct acid secretion_Homo sapiens_hsa049661.58195951
37Linoleic acid metabolism_Homo sapiens_hsa005911.57222435
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56678777
39Basal transcription factors_Homo sapiens_hsa030221.47583719
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46805289
41Circadian rhythm_Homo sapiens_hsa047101.39498063
42Vibrio cholerae infection_Homo sapiens_hsa051101.37911298
43Peroxisome_Homo sapiens_hsa041461.35043658
44Non-homologous end-joining_Homo sapiens_hsa034501.33992671
45Sulfur metabolism_Homo sapiens_hsa009201.31959444
46RNA polymerase_Homo sapiens_hsa030201.30547697
47Long-term depression_Homo sapiens_hsa047301.30259140
48Oxidative phosphorylation_Homo sapiens_hsa001901.27473762
49Oxytocin signaling pathway_Homo sapiens_hsa049211.26318485
50Fatty acid metabolism_Homo sapiens_hsa012121.25018316
51Calcium signaling pathway_Homo sapiens_hsa040201.24169205
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.21093731
53* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18695766
54Gap junction_Homo sapiens_hsa045401.18519988
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17579082
56Fanconi anemia pathway_Homo sapiens_hsa034601.17055505
57GnRH signaling pathway_Homo sapiens_hsa049121.15286097
58ABC transporters_Homo sapiens_hsa020101.14256886
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14059793
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10058519
61Axon guidance_Homo sapiens_hsa043601.09585794
62Vitamin B6 metabolism_Homo sapiens_hsa007501.09410725
63One carbon pool by folate_Homo sapiens_hsa006701.09346888
64Parkinsons disease_Homo sapiens_hsa050121.04594179
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02328782
66beta-Alanine metabolism_Homo sapiens_hsa004100.99744906
67RNA degradation_Homo sapiens_hsa030180.99503023
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96374713
69cAMP signaling pathway_Homo sapiens_hsa040240.96175275
70Dilated cardiomyopathy_Homo sapiens_hsa054140.95513988
71Type II diabetes mellitus_Homo sapiens_hsa049300.95225858
72Homologous recombination_Homo sapiens_hsa034400.95186227
73Sphingolipid metabolism_Homo sapiens_hsa006000.91491405
74Caffeine metabolism_Homo sapiens_hsa002320.90442728
75Fatty acid degradation_Homo sapiens_hsa000710.89241559
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89181979
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88631695
78Bile secretion_Homo sapiens_hsa049760.87157998
79Thyroid hormone synthesis_Homo sapiens_hsa049180.84743801
80Alzheimers disease_Homo sapiens_hsa050100.84637206
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81640196
82Melanogenesis_Homo sapiens_hsa049160.80670063
83Butanoate metabolism_Homo sapiens_hsa006500.80587026
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80484806
85Estrogen signaling pathway_Homo sapiens_hsa049150.79940813
86Dorso-ventral axis formation_Homo sapiens_hsa043200.76492798
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.73382325
88Pancreatic secretion_Homo sapiens_hsa049720.71096388
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70224722
90Metabolic pathways_Homo sapiens_hsa011000.69919570
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69864132
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69171207
93ErbB signaling pathway_Homo sapiens_hsa040120.68915431
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.67588983
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.67530599
96Choline metabolism in cancer_Homo sapiens_hsa052310.66111802
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63121472
98Folate biosynthesis_Homo sapiens_hsa007900.62945715
99Huntingtons disease_Homo sapiens_hsa050160.62520042
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61927566
101Arachidonic acid metabolism_Homo sapiens_hsa005900.61648691
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60197521
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59709010
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59644670
105Retinol metabolism_Homo sapiens_hsa008300.59398367
106Arginine biosynthesis_Homo sapiens_hsa002200.59100931
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58803392
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58366518
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57765517
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57540048
111Chemical carcinogenesis_Homo sapiens_hsa052040.57507209
112N-Glycan biosynthesis_Homo sapiens_hsa005100.57179219
113Ovarian steroidogenesis_Homo sapiens_hsa049130.56900554
114MAPK signaling pathway_Homo sapiens_hsa040100.55953630
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55644056
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54810534
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53697992
118Mineral absorption_Homo sapiens_hsa049780.53628863
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52997563
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52474122
121Ras signaling pathway_Homo sapiens_hsa040140.51586360
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51548935
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.51309098
124Lysine degradation_Homo sapiens_hsa003100.50942450
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49305747
126Phenylalanine metabolism_Homo sapiens_hsa003600.48800736
127Steroid biosynthesis_Homo sapiens_hsa001000.47728510
128Prion diseases_Homo sapiens_hsa050200.45370244
129Oocyte meiosis_Homo sapiens_hsa041140.44921876
130Purine metabolism_Homo sapiens_hsa002300.44328918
131Type I diabetes mellitus_Homo sapiens_hsa049400.43803538
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42603469
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42124267
134Rheumatoid arthritis_Homo sapiens_hsa053230.41000500
135Arginine and proline metabolism_Homo sapiens_hsa003300.40703146
136Glioma_Homo sapiens_hsa052140.40506596
137Ether lipid metabolism_Homo sapiens_hsa005650.38504064
138Alcoholism_Homo sapiens_hsa050340.38316153
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.37607404
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36831694
141Tryptophan metabolism_Homo sapiens_hsa003800.35451078
142Fatty acid biosynthesis_Homo sapiens_hsa000610.35167480
143Glucagon signaling pathway_Homo sapiens_hsa049220.34775675
144Fatty acid elongation_Homo sapiens_hsa000620.34451402
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33974995
146Hedgehog signaling pathway_Homo sapiens_hsa043400.32672860
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32586124
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32141578
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31751918
150Endocytosis_Homo sapiens_hsa041440.26793254
151Wnt signaling pathway_Homo sapiens_hsa043100.25901946
152Inositol phosphate metabolism_Homo sapiens_hsa005620.25894657
153Phagosome_Homo sapiens_hsa041450.25078677

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