GLRA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.05514781
2neuron cell-cell adhesion (GO:0007158)5.92149128
3vocalization behavior (GO:0071625)5.91594613
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.47220088
5synaptic vesicle maturation (GO:0016188)5.47050027
6synaptic vesicle exocytosis (GO:0016079)5.45721082
7regulation of glutamate receptor signaling pathway (GO:1900449)5.29500882
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16951609
9locomotory exploration behavior (GO:0035641)5.13135814
10exploration behavior (GO:0035640)5.07069803
11protein localization to synapse (GO:0035418)4.84705317
12layer formation in cerebral cortex (GO:0021819)4.84671889
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.83327650
14regulation of synaptic vesicle exocytosis (GO:2000300)4.74381143
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.73236243
16pyrimidine nucleobase catabolic process (GO:0006208)4.66938560
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.58351254
18neurotransmitter secretion (GO:0007269)4.58020978
19neuron recognition (GO:0008038)4.54638436
20proline transport (GO:0015824)4.49585328
21postsynaptic membrane organization (GO:0001941)4.43294454
22glutamate secretion (GO:0014047)4.43280762
23dendritic spine morphogenesis (GO:0060997)4.36048227
24mechanosensory behavior (GO:0007638)4.31589230
25regulation of synapse structural plasticity (GO:0051823)4.30564543
26startle response (GO:0001964)4.25076498
27glutamate receptor signaling pathway (GO:0007215)4.20994504
28regulation of synaptic vesicle transport (GO:1902803)4.18671979
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.14523344
30neurotransmitter-gated ion channel clustering (GO:0072578)4.12054649
31axonal fasciculation (GO:0007413)4.10600757
32neurofilament cytoskeleton organization (GO:0060052)4.01798626
33neuron-neuron synaptic transmission (GO:0007270)3.98796697
34synaptic transmission, glutamatergic (GO:0035249)3.97559610
35gamma-aminobutyric acid transport (GO:0015812)3.96824148
36presynaptic membrane assembly (GO:0097105)3.90538185
37nucleobase catabolic process (GO:0046113)3.86375867
38positive regulation of action potential (GO:0045760)3.85689188
39dendrite morphogenesis (GO:0048813)3.84799994
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.80113206
41neurotransmitter transport (GO:0006836)3.79471439
42response to histamine (GO:0034776)3.76605207
43transmission of nerve impulse (GO:0019226)3.68120865
44serotonin metabolic process (GO:0042428)3.65431557
45regulation of neuronal synaptic plasticity (GO:0048168)3.64902578
46cell migration in hindbrain (GO:0021535)3.62858333
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.59940078
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.59477624
49behavioral defense response (GO:0002209)3.58109408
50behavioral fear response (GO:0001662)3.58109408
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.55001145
52regulation of neurotransmitter levels (GO:0001505)3.53968538
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.52638273
54behavioral response to nicotine (GO:0035095)3.52620171
55positive regulation of synapse assembly (GO:0051965)3.52513511
56neuromuscular synaptic transmission (GO:0007274)3.48191020
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47926900
58presynaptic membrane organization (GO:0097090)3.46393300
59activation of protein kinase A activity (GO:0034199)3.46031386
60central nervous system projection neuron axonogenesis (GO:0021952)3.45105334
61membrane depolarization during action potential (GO:0086010)3.37960642
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35311477
63regulation of vesicle fusion (GO:0031338)3.35196537
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.34773761
65positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.33788990
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.33126845
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.33026403
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.32707745
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32370244
70positive regulation of membrane potential (GO:0045838)3.30135085
71regulation of postsynaptic membrane potential (GO:0060078)3.30134958
72dopamine receptor signaling pathway (GO:0007212)3.29450764
73neuronal action potential propagation (GO:0019227)3.28916266
74positive regulation of synapse maturation (GO:0090129)3.27989985
75long-term memory (GO:0007616)3.27862439
76synaptic vesicle endocytosis (GO:0048488)3.26962276
77clathrin coat assembly (GO:0048268)3.26651030
78negative regulation of microtubule polymerization (GO:0031115)3.21887445
79dendrite development (GO:0016358)3.21109279
80fear response (GO:0042596)3.20927534
81neuronal action potential (GO:0019228)3.20512807
82auditory behavior (GO:0031223)3.20304535
83social behavior (GO:0035176)3.19686285
84intraspecies interaction between organisms (GO:0051703)3.19686285
85neuromuscular process controlling posture (GO:0050884)3.18085580
86* synapse assembly (GO:0007416)3.16695015
87regulation of cAMP-dependent protein kinase activity (GO:2000479)3.15543174
88cerebellar Purkinje cell differentiation (GO:0021702)3.14412491
89regulation of synapse assembly (GO:0051963)3.12127496
90atrial cardiac muscle cell action potential (GO:0086014)3.11905406
91mitochondrion transport along microtubule (GO:0047497)3.10747186
92establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.10747186
93axon extension (GO:0048675)3.09786923
94membrane hyperpolarization (GO:0060081)3.09293139
95negative regulation of axon extension (GO:0030517)3.09163800
96regulation of synaptic transmission, GABAergic (GO:0032228)3.08058268
97regulation of action potential (GO:0098900)3.07210336
98urinary tract smooth muscle contraction (GO:0014848)3.06362426
99establishment of mitochondrion localization (GO:0051654)3.05745960
100organelle transport along microtubule (GO:0072384)3.05290492
101tachykinin receptor signaling pathway (GO:0007217)3.04174257
102membrane assembly (GO:0071709)3.04043508
103regulation of neurotransmitter secretion (GO:0046928)3.03749381
104response to auditory stimulus (GO:0010996)3.03249781
105learning (GO:0007612)3.02946439
106short-term memory (GO:0007614)3.02281446
107primary amino compound metabolic process (GO:1901160)3.01634893
108opioid receptor signaling pathway (GO:0038003)3.00582276
109membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00110525
110regulation of axon guidance (GO:1902667)2.99565524
111response to pheromone (GO:0019236)2.98472914
112regulation of respiratory system process (GO:0044065)2.98428481
113regulation of glutamate secretion (GO:0014048)2.98031122
114neuron projection extension (GO:1990138)2.97065809
115nonmotile primary cilium assembly (GO:0035058)2.95437251
116regulation of dendritic spine morphogenesis (GO:0061001)2.94060403
117* synapse organization (GO:0050808)2.94044206
118long-term synaptic potentiation (GO:0060291)2.93395839
119central nervous system neuron axonogenesis (GO:0021955)2.93170181
120epithelial cell differentiation involved in kidney development (GO:0035850)2.92934770
121vesicle transport along microtubule (GO:0047496)2.92753421
122adult walking behavior (GO:0007628)2.92295497
123cerebral cortex radially oriented cell migration (GO:0021799)2.89785925
124synaptic transmission, cholinergic (GO:0007271)2.87713134
125heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.83374495
126cerebellar granule cell differentiation (GO:0021707)2.83263561
127membrane depolarization (GO:0051899)2.81383038
128neuronal ion channel clustering (GO:0045161)2.79985775
129regulation of synapse organization (GO:0050807)2.79790462
130positive regulation of dendritic spine morphogenesis (GO:0061003)2.79177999
131adult behavior (GO:0030534)2.77186336
132nerve growth factor signaling pathway (GO:0038180)2.75094996
133negative regulation of axonogenesis (GO:0050771)2.74156110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.69662866
2GBX2_23144817_ChIP-Seq_PC3_Human3.87733097
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06430574
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03087234
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.02978152
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90281384
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.67951008
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.64259865
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56304374
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54719739
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54719739
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53118002
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50502710
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43377083
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36822699
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36367604
17TAF15_26573619_Chip-Seq_HEK293_Human2.30187317
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28894116
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26238952
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23104127
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.22870713
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.22799171
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22465466
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18106697
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.16252910
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.08148280
27DROSHA_22980978_ChIP-Seq_HELA_Human2.06253953
28AR_21572438_ChIP-Seq_LNCaP_Human2.00100282
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98935748
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88378412
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.88163074
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87240759
33ZNF274_21170338_ChIP-Seq_K562_Hela1.78226678
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.73593364
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71163625
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.68605704
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65555949
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62962554
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62051196
40* P300_19829295_ChIP-Seq_ESCs_Human1.61913174
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57718026
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54147296
43* RNF2_27304074_Chip-Seq_NSC_Mouse1.53727556
44IGF1R_20145208_ChIP-Seq_DFB_Human1.47164479
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44925760
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44156765
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41832600
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.41429287
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40178602
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.39450983
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38754425
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37398107
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36969989
54FUS_26573619_Chip-Seq_HEK293_Human1.36592476
55AR_25329375_ChIP-Seq_VCAP_Human1.34849806
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34288375
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33340793
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31262856
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30060130
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29308560
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.28883553
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.28710547
63ER_23166858_ChIP-Seq_MCF-7_Human1.27844650
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.26124932
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24847709
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23032289
67* STAT3_23295773_ChIP-Seq_U87_Human1.18867681
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.18861556
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17697100
70LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17146200
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.16086386
72EWS_26573619_Chip-Seq_HEK293_Human1.15634634
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14918111
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14410694
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13033318
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11029539
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10392574
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10263384
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10263384
80TCF4_23295773_ChIP-Seq_U87_Human1.10151725
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.09681678
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09564339
83* AR_19668381_ChIP-Seq_PC3_Human1.09377887
84RUNX2_22187159_ChIP-Seq_PCA_Human1.08992946
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.08879529
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07482246
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.06430860
88AHR_22903824_ChIP-Seq_MCF-7_Human1.06405077
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05693825
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05483576
91BCAT_22108803_ChIP-Seq_LS180_Human1.04847268
92JUN_21703547_ChIP-Seq_K562_Human1.04282586
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03553206
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02391467
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02205220
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01756269
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00687583
98FLI1_21867929_ChIP-Seq_TH2_Mouse0.98974826
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.98554272
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98251453
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97360518
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96823890
103DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96817729
104TP53_18474530_ChIP-ChIP_U2OS_Human0.95960757
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.93887645
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93579476
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.93069506
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.92731537
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91189410
110KDM2B_26808549_Chip-Seq_REH_Human0.90898852
111VDR_22108803_ChIP-Seq_LS180_Human0.88515971
112CBP_20019798_ChIP-Seq_JUKART_Human0.87276519
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87276519
114WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87005104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08326383
2MP0003880_abnormal_central_pattern4.34447641
3* MP0003635_abnormal_synaptic_transmissio3.92294389
4MP0005423_abnormal_somatic_nervous3.55266323
5MP0004270_analgesia3.42092643
6MP0006276_abnormal_autonomic_nervous3.41722625
7MP0009745_abnormal_behavioral_response3.32565077
8MP0002063_abnormal_learning/memory/cond3.26404851
9MP0002064_seizures2.96074692
10MP0009046_muscle_twitch2.95695541
11MP0002572_abnormal_emotion/affect_behav2.94323306
12MP0001968_abnormal_touch/_nociception2.93654207
13MP0002734_abnormal_mechanical_nocicepti2.81439173
14MP0001501_abnormal_sleep_pattern2.61495477
15MP0003122_maternal_imprinting2.57090568
16MP0005645_abnormal_hypothalamus_physiol2.49649801
17MP0001486_abnormal_startle_reflex2.48244071
18MP0002733_abnormal_thermal_nociception2.42644388
19MP0002735_abnormal_chemical_nociception2.34365273
20MP0000778_abnormal_nervous_system2.34097173
21* MP0002272_abnormal_nervous_system2.31220377
22MP0002184_abnormal_innervation2.24775441
23MP0001440_abnormal_grooming_behavior2.17978601
24MP0003787_abnormal_imprinting2.17726514
25MP0002736_abnormal_nociception_after2.14343944
26MP0002557_abnormal_social/conspecific_i2.10753401
27MP0001970_abnormal_pain_threshold2.08181436
28MP0002822_catalepsy1.95438174
29MP0009780_abnormal_chondrocyte_physiolo1.92193361
30MP0005386_behavior/neurological_phenoty1.89804957
31MP0004924_abnormal_behavior1.89804957
32MP0002067_abnormal_sensory_capabilities1.87878908
33MP0004811_abnormal_neuron_physiology1.71486890
34MP0005646_abnormal_pituitary_gland1.68626016
35MP0003329_amyloid_beta_deposits1.65737676
36MP0001529_abnormal_vocalization1.64501109
37MP0004142_abnormal_muscle_tone1.59594906
38MP0000569_abnormal_digit_pigmentation1.59004921
39MP0001188_hyperpigmentation1.56506387
40MP0000955_abnormal_spinal_cord1.54928532
41MP0002882_abnormal_neuron_morphology1.49980173
42MP0002909_abnormal_adrenal_gland1.49172832
43MP0008877_abnormal_DNA_methylation1.47220348
44MP0002066_abnormal_motor_capabilities/c1.42098356
45MP0001984_abnormal_olfaction1.36388649
46MP0003879_abnormal_hair_cell1.35511780
47MP0004858_abnormal_nervous_system1.34436994
48MP0008569_lethality_at_weaning1.28058154
49MP0003283_abnormal_digestive_organ1.25363979
50MP0000566_synostosis1.23084242
51MP0004885_abnormal_endolymph1.21068263
52MP0001502_abnormal_circadian_rhythm1.19516608
53MP0002152_abnormal_brain_morphology1.19039547
54MP0001905_abnormal_dopamine_level1.17370661
55MP0003121_genomic_imprinting1.15298824
56MP0000631_abnormal_neuroendocrine_gland1.09020543
57MP0005499_abnormal_olfactory_system1.05506528
58MP0005394_taste/olfaction_phenotype1.05506528
59MP0004133_heterotaxia1.04498922
60MP0004145_abnormal_muscle_electrophysio1.01000563
61MP0002876_abnormal_thyroid_physiology0.98028288
62MP0004085_abnormal_heartbeat0.97756567
63MP0005551_abnormal_eye_electrophysiolog0.96698400
64MP0000751_myopathy0.95980128
65MP0002102_abnormal_ear_morphology0.95005917
66MP0003633_abnormal_nervous_system0.92622438
67MP0004742_abnormal_vestibular_system0.92271685
68MP0002069_abnormal_eating/drinking_beha0.91808339
69MP0005535_abnormal_body_temperature0.91281489
70MP0002752_abnormal_somatic_nervous0.88783193
71MP0003123_paternal_imprinting0.87285213
72MP0002837_dystrophic_cardiac_calcinosis0.85758339
73MP0003631_nervous_system_phenotype0.85405159
74MP0002229_neurodegeneration0.84463225
75MP0001177_atelectasis0.82839586
76MP0003567_abnormal_fetal_cardiomyocyte0.82197758
77MP0001963_abnormal_hearing_physiology0.81125157
78MP0002638_abnormal_pupillary_reflex0.80716576
79MP0001348_abnormal_lacrimal_gland0.79307983
80MP0006292_abnormal_olfactory_placode0.77522131
81MP0003119_abnormal_digestive_system0.76590466
82MP0008874_decreased_physiological_sensi0.75001344
83MP0005195_abnormal_posterior_eye0.73634746
84MP0003634_abnormal_glial_cell0.73595904
85MP0003861_abnormal_nervous_system0.73173035
86MP0002081_perinatal_lethality0.72968126
87MP0005409_darkened_coat_color0.68103093
88MP0010386_abnormal_urinary_bladder0.68057438
89MP0005253_abnormal_eye_physiology0.67087354
90MP0003890_abnormal_embryonic-extraembry0.66784620
91MP0003137_abnormal_impulse_conducting0.66360113
92MP0005248_abnormal_Harderian_gland0.66043262
93MP0008789_abnormal_olfactory_epithelium0.65753609
94MP0001943_abnormal_respiration0.65593170
95MP0002090_abnormal_vision0.65429913
96MP0000026_abnormal_inner_ear0.65383744
97MP0004130_abnormal_muscle_cell0.65207862
98MP0001299_abnormal_eye_distance/0.64949451
99MP0001346_abnormal_lacrimal_gland0.64016987
100MP0004215_abnormal_myocardial_fiber0.63729670
101MP0003183_abnormal_peptide_metabolism0.63613958
102MP0000604_amyloidosis0.63224323
103MP0003632_abnormal_nervous_system0.63176269
104MP0005187_abnormal_penis_morphology0.61677201
105MP0002082_postnatal_lethality0.59010794
106MP0010770_preweaning_lethality0.59010794
107MP0006072_abnormal_retinal_apoptosis0.58968400
108MP0002234_abnormal_pharynx_morphology0.58299119
109MP0001485_abnormal_pinna_reflex0.57729157
110MP0000013_abnormal_adipose_tissue0.57324329
111MP0010769_abnormal_survival0.56849514
112MP0003938_abnormal_ear_development0.56277721
113MP0008872_abnormal_physiological_respon0.54648069
114MP0001664_abnormal_digestion0.54536315
115MP0002751_abnormal_autonomic_nervous0.53701144
116MP0010768_mortality/aging0.52927910
117MP0000537_abnormal_urethra_morphology0.50085603

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.23542709
2Focal seizures (HP:0007359)5.47315609
3Myokymia (HP:0002411)5.14868667
4Visual hallucinations (HP:0002367)4.88497117
5Atonic seizures (HP:0010819)4.71499076
6Epileptic encephalopathy (HP:0200134)4.61361767
7Febrile seizures (HP:0002373)4.39569017
8Absence seizures (HP:0002121)4.15844453
9Mutism (HP:0002300)4.06935850
10Progressive cerebellar ataxia (HP:0002073)4.00614502
11Supranuclear gaze palsy (HP:0000605)3.83192430
12Polyphagia (HP:0002591)3.74695492
13Generalized tonic-clonic seizures (HP:0002069)3.73508682
14Dialeptic seizures (HP:0011146)3.69520187
15Broad-based gait (HP:0002136)3.60514733
16Hyperventilation (HP:0002883)3.58860200
17Excessive salivation (HP:0003781)3.57537847
18Drooling (HP:0002307)3.57537847
19Ankle clonus (HP:0011448)3.36246911
20Limb dystonia (HP:0002451)3.35880660
21Progressive inability to walk (HP:0002505)3.21689688
22Amyotrophic lateral sclerosis (HP:0007354)3.21266909
23Akinesia (HP:0002304)3.16013542
24Abnormality of the corticospinal tract (HP:0002492)3.15796707
25Papilledema (HP:0001085)3.08917696
26Ulnar claw (HP:0001178)3.08834326
27Abnormal eating behavior (HP:0100738)3.05277890
28Fetal akinesia sequence (HP:0001989)2.99032117
29Poor eye contact (HP:0000817)2.90359811
30Agitation (HP:0000713)2.82669427
31Diplopia (HP:0000651)2.79002574
32Abnormality of binocular vision (HP:0011514)2.79002574
33Urinary bladder sphincter dysfunction (HP:0002839)2.77856254
34Epileptiform EEG discharges (HP:0011182)2.75390028
35Pheochromocytoma (HP:0002666)2.72431966
36EEG with generalized epileptiform discharges (HP:0011198)2.71299417
37Depression (HP:0000716)2.69885808
38Abnormal social behavior (HP:0012433)2.68871177
39Impaired social interactions (HP:0000735)2.68871177
40Anxiety (HP:0000739)2.67688277
41Poor suck (HP:0002033)2.66440426
42Abnormality of midbrain morphology (HP:0002418)2.66178318
43Molar tooth sign on MRI (HP:0002419)2.66178318
44Hypsarrhythmia (HP:0002521)2.65821043
45Genetic anticipation (HP:0003743)2.65616202
46Hyperthyroidism (HP:0000836)2.64919702
47Inappropriate behavior (HP:0000719)2.63732443
48Retinal dysplasia (HP:0007973)2.63593437
49Impaired vibration sensation in the lower limbs (HP:0002166)2.62467189
50Amblyopia (HP:0000646)2.62268958
51Truncal ataxia (HP:0002078)2.61600482
52Termporal pattern (HP:0011008)2.60907268
53Insidious onset (HP:0003587)2.60907268
54Absent speech (HP:0001344)2.53884793
55Urinary urgency (HP:0000012)2.52464253
56Nephronophthisis (HP:0000090)2.51576098
57Inability to walk (HP:0002540)2.50440288
58Dysdiadochokinesis (HP:0002075)2.48240729
59Postural instability (HP:0002172)2.48086712
60Failure to thrive in infancy (HP:0001531)2.46458249
61Cortical dysplasia (HP:0002539)2.45640304
62Action tremor (HP:0002345)2.44846093
63Hemiparesis (HP:0001269)2.43234342
64Gait imbalance (HP:0002141)2.43183034
65Cerebral inclusion bodies (HP:0100314)2.43050547
66Neurofibrillary tangles (HP:0002185)2.41696252
67Torticollis (HP:0000473)2.40811732
68Spastic gait (HP:0002064)2.40193488
69Aplasia/Hypoplasia of the brainstem (HP:0007362)2.39295090
70Hypoplasia of the brainstem (HP:0002365)2.39295090
71Abnormality of salivation (HP:0100755)2.37091720
72Neuroendocrine neoplasm (HP:0100634)2.34171768
73Gaze-evoked nystagmus (HP:0000640)2.32761803
74Medial flaring of the eyebrow (HP:0010747)2.32474553
75Blue irides (HP:0000635)2.31146733
76Stereotypic behavior (HP:0000733)2.30456026
77Abnormal hair whorl (HP:0010721)2.30173235
78Bradykinesia (HP:0002067)2.23766657
79Protruding tongue (HP:0010808)2.23523767
80Congenital primary aphakia (HP:0007707)2.21093948
81Dysmetria (HP:0001310)2.20416176
82True hermaphroditism (HP:0010459)2.19643706
83Sleep apnea (HP:0010535)2.15985456
84Type II lissencephaly (HP:0007260)2.11870322
85Aqueductal stenosis (HP:0002410)2.11715615
86Lissencephaly (HP:0001339)2.11014549
87Specific learning disability (HP:0001328)2.10858695
88Lower limb muscle weakness (HP:0007340)2.10643640
89Hepatoblastoma (HP:0002884)2.08031846
90Focal dystonia (HP:0004373)2.06496295
91Intellectual disability, severe (HP:0010864)2.06384312
92Morphological abnormality of the pyramidal tract (HP:0002062)2.05829633
93Esotropia (HP:0000565)2.04061282
94Pancreatic cysts (HP:0001737)2.03827624
95Nephrogenic diabetes insipidus (HP:0009806)2.03368883
96Hypoplasia of the corpus callosum (HP:0002079)2.01818799
97Megalencephaly (HP:0001355)2.01546439
98Spastic tetraplegia (HP:0002510)1.99115237
99Vaginal atresia (HP:0000148)1.98648857
100Abnormality of the lower motor neuron (HP:0002366)1.97752108
101Generalized myoclonic seizures (HP:0002123)1.96818992
102Shawl scrotum (HP:0000049)1.96763875
103Craniofacial dystonia (HP:0012179)1.96172568
104Pancreatic fibrosis (HP:0100732)1.96054930
105Psychosis (HP:0000709)1.95697300
106Narrow nasal bridge (HP:0000446)1.95657726
107Abnormality of the labia minora (HP:0012880)1.95034421
108Genital tract atresia (HP:0001827)1.94395257
109Generalized hypotonia (HP:0001290)1.93930956
110Abnormality of the renal medulla (HP:0100957)1.93900230
111Optic nerve hypoplasia (HP:0000609)1.92930381
112Impaired smooth pursuit (HP:0007772)1.92702369
113Generalized hypopigmentation of hair (HP:0011358)1.91308188
114Exotropia (HP:0000577)1.91127471
115Hypoventilation (HP:0002791)1.91043144
116Narrow forehead (HP:0000341)1.90929224
117Polymicrogyria (HP:0002126)1.88192987
118Sporadic (HP:0003745)1.87094613
119Apathy (HP:0000741)1.80795878
120Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79978501
121Degeneration of the lateral corticospinal tracts (HP:0002314)1.79978501
122Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77446817
123Scanning speech (HP:0002168)1.75887582
124Anterior segment dysgenesis (HP:0007700)1.75402094
125Status epilepticus (HP:0002133)1.75320447
126Pachygyria (HP:0001302)1.73927701
127Muscular hypotonia of the trunk (HP:0008936)1.72962955
128Hemiplegia (HP:0002301)1.72282078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.43531455
2NTRK34.13320786
3MAP3K93.22127515
4MAP3K43.21678106
5MAP2K73.09825762
6CASK3.03037042
7MAP3K122.88046831
8MINK12.68660338
9NTRK22.64594384
10MAPK132.30707244
11TNIK2.20806003
12MAP2K42.00567316
13EPHA41.93854913
14PAK61.77855144
15SIK21.76241224
16PHKG11.74512734
17PHKG21.74512734
18WNK31.62100243
19DAPK21.51720151
20LATS21.50368085
21DYRK21.49042319
22PLK21.48791623
23CDK51.38256227
24PNCK1.37985507
25KSR11.37544150
26CSNK1G21.36666503
27PINK11.34686717
28PRKCG1.31533052
29CDK191.28060439
30ERBB31.26787534
31GRK51.25847606
32UHMK11.21007035
33CAMK2A1.14861531
34MAP4K21.13829614
35DAPK11.13692863
36CAMKK11.03636350
37PRPF4B1.03385130
38NTRK10.96296264
39MARK20.96127439
40FES0.94881327
41DYRK1A0.91464776
42GRK70.89154998
43PAK30.88422955
44MAP3K60.88221829
45CSNK1G30.87111948
46EPHA30.84831654
47PKN10.83398896
48CDK180.83395997
49CDK140.81436096
50FRK0.81054975
51KSR20.80887875
52CDK150.80707820
53TRIM280.80229975
54ADRBK20.78193432
55BMPR1B0.75845608
56PRKCE0.73833295
57ACVR1B0.70916111
58CDK11A0.70863292
59MAP3K20.68780933
60ADRBK10.66305344
61OXSR10.62804099
62BCR0.59597344
63STK110.59459466
64SGK10.58995744
65PRKCZ0.58493297
66SGK2230.58468055
67SGK4940.58468055
68ZAK0.57949930
69CAMK10.56775739
70AKT30.56539539
71CAMK2B0.56538376
72RET0.55316445
73CCNB10.54100479
74RPS6KA20.53772049
75ALK0.52509496
76CSNK1A1L0.52096800
77RIPK40.51979300
78MAPK120.49663059
79STK380.49386396
80SIK30.47558493
81MAP2K60.47352722
82MAPK40.46259574
83SGK20.46240820
84PRKD30.46127646
85SCYL20.45995091
86FYN0.45758599
87TYRO30.45494513
88TAOK10.44988053
89CSNK1G10.43999797
90CSNK1E0.43886522
91RPS6KA30.42714706
92WNK40.41860342
93EPHB20.41680328
94CSNK1D0.39238748
95MAPK90.39197158
96PRKCB0.39039972
97CAMK2G0.37754874
98PRKG10.37369633
99CAMKK20.36286343
100PRKCH0.35316628
101CAMK1G0.35297626
102NME10.34710651
103LIMK10.34693170
104MKNK20.32816176
105MAPK100.32102491
106MAPK80.32075640
107SGK30.31960364
108PRKCI0.31117825
109CAMK2D0.30851368
110PRKACA0.30698401
111RPS6KB10.30593916
112LMTK20.30058561
113CAMK40.29953939
114PRKACB0.29686408
115TGFBR10.28953577
116ERBB40.28735017
117TAOK30.26750731
118PRKAA10.26298680
119GSK3B0.25823299
120TAF10.25191145

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.31908548
2Synaptic vesicle cycle_Homo sapiens_hsa047213.66534245
3GABAergic synapse_Homo sapiens_hsa047273.07677857
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85019830
5Morphine addiction_Homo sapiens_hsa050322.75051711
6Olfactory transduction_Homo sapiens_hsa047402.66117615
7Circadian entrainment_Homo sapiens_hsa047132.58528330
8Glutamatergic synapse_Homo sapiens_hsa047242.48385074
9Serotonergic synapse_Homo sapiens_hsa047262.25535943
10Dopaminergic synapse_Homo sapiens_hsa047282.21623172
11Long-term potentiation_Homo sapiens_hsa047202.17367995
12Amphetamine addiction_Homo sapiens_hsa050312.08655969
13Taste transduction_Homo sapiens_hsa047422.01389234
14Cholinergic synapse_Homo sapiens_hsa047251.98020474
15Collecting duct acid secretion_Homo sapiens_hsa049661.96688082
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93016419
17Salivary secretion_Homo sapiens_hsa049701.88189876
18Cocaine addiction_Homo sapiens_hsa050301.80266597
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79406858
20Long-term depression_Homo sapiens_hsa047301.76097650
21Insulin secretion_Homo sapiens_hsa049111.71179431
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.65179099
23Renin secretion_Homo sapiens_hsa049241.60361192
24Axon guidance_Homo sapiens_hsa043601.51973044
25Gap junction_Homo sapiens_hsa045401.46791000
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46500925
27Oxytocin signaling pathway_Homo sapiens_hsa049211.44886563
28* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44453601
29Gastric acid secretion_Homo sapiens_hsa049711.43411088
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43254238
31Vibrio cholerae infection_Homo sapiens_hsa051101.35649500
32Calcium signaling pathway_Homo sapiens_hsa040201.32304915
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21979477
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18217611
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16246681
36GnRH signaling pathway_Homo sapiens_hsa049121.15619416
37Type II diabetes mellitus_Homo sapiens_hsa049301.09333590
38Estrogen signaling pathway_Homo sapiens_hsa049151.08079559
39Phototransduction_Homo sapiens_hsa047441.07353942
40Cardiac muscle contraction_Homo sapiens_hsa042601.06530360
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01231527
42cAMP signaling pathway_Homo sapiens_hsa040241.01212436
43ErbB signaling pathway_Homo sapiens_hsa040121.00067381
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96438510
45Glioma_Homo sapiens_hsa052140.92882718
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90773636
47Melanogenesis_Homo sapiens_hsa049160.88448337
48Type I diabetes mellitus_Homo sapiens_hsa049400.85942758
49Ether lipid metabolism_Homo sapiens_hsa005650.83043106
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78746300
51Butanoate metabolism_Homo sapiens_hsa006500.78535067
52Oxidative phosphorylation_Homo sapiens_hsa001900.78398032
53Linoleic acid metabolism_Homo sapiens_hsa005910.77963975
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77392251
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77141406
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.74181428
57Dilated cardiomyopathy_Homo sapiens_hsa054140.73824770
58Oocyte meiosis_Homo sapiens_hsa041140.73675488
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72996008
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70780707
61MAPK signaling pathway_Homo sapiens_hsa040100.70716289
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70654397
63Alcoholism_Homo sapiens_hsa050340.70248288
64Alzheimers disease_Homo sapiens_hsa050100.69250599
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65528626
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61178795
67Dorso-ventral axis formation_Homo sapiens_hsa043200.61014552
68Parkinsons disease_Homo sapiens_hsa050120.60839703
69Ras signaling pathway_Homo sapiens_hsa040140.60680829
70Hippo signaling pathway_Homo sapiens_hsa043900.60325141
71Regulation of autophagy_Homo sapiens_hsa041400.58506617
72Steroid biosynthesis_Homo sapiens_hsa001000.57233378
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.56485629
74Hedgehog signaling pathway_Homo sapiens_hsa043400.54541443
75Choline metabolism in cancer_Homo sapiens_hsa052310.54466244
76Endometrial cancer_Homo sapiens_hsa052130.53964608
77Bile secretion_Homo sapiens_hsa049760.53782205
78Circadian rhythm_Homo sapiens_hsa047100.53637269
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52202939
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.52032719
81Prion diseases_Homo sapiens_hsa050200.51561756
82Ovarian steroidogenesis_Homo sapiens_hsa049130.51560428
83Colorectal cancer_Homo sapiens_hsa052100.51201859
84Thyroid hormone synthesis_Homo sapiens_hsa049180.51039936
85Phagosome_Homo sapiens_hsa041450.50824626
86Renal cell carcinoma_Homo sapiens_hsa052110.49236219
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48208022
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48198911
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48190672
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48043060
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47551067
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44839758
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44270815
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44047051
95Rheumatoid arthritis_Homo sapiens_hsa053230.43125018
96mTOR signaling pathway_Homo sapiens_hsa041500.42020962
97Protein export_Homo sapiens_hsa030600.41662081
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41158082
99Insulin signaling pathway_Homo sapiens_hsa049100.40612221
100Wnt signaling pathway_Homo sapiens_hsa043100.39933423
101Basal transcription factors_Homo sapiens_hsa030220.39134899
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39087565
103Glucagon signaling pathway_Homo sapiens_hsa049220.38765861
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38671030
105Huntingtons disease_Homo sapiens_hsa050160.38425501
106Rap1 signaling pathway_Homo sapiens_hsa040150.37906416
107Fatty acid biosynthesis_Homo sapiens_hsa000610.36100806
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.34803218
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34285549
110Prolactin signaling pathway_Homo sapiens_hsa049170.34283976
111Pancreatic secretion_Homo sapiens_hsa049720.34224281
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.33980448
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33829920
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31666202
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30931240
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30771875
117Endocytosis_Homo sapiens_hsa041440.30312326
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30000139
119Tight junction_Homo sapiens_hsa045300.29729993
120Melanoma_Homo sapiens_hsa052180.26325352
121Chemokine signaling pathway_Homo sapiens_hsa040620.24983487

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