GLRA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. The encoded protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to methylmercury (GO:0051597)9.74813139
2acrosome reaction (GO:0007340)9.11740145
3microtubule depolymerization (GO:0007019)8.93136852
4plasma membrane fusion (GO:0045026)8.91601365
5sperm motility (GO:0030317)8.77897645
6central nervous system myelination (GO:0022010)7.38833485
7axon ensheathment in central nervous system (GO:0032291)7.38833485
8response to pheromone (GO:0019236)7.23318326
9sperm capacitation (GO:0048240)6.97741782
10cholesterol biosynthetic process (GO:0006695)6.89310743
11long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.71775924
12amyloid precursor protein metabolic process (GO:0042982)6.63840812
13single strand break repair (GO:0000012)6.45030445
14microtubule polymerization or depolymerization (GO:0031109)6.24723691
15chromosome condensation (GO:0030261)6.21683931
16long-chain fatty-acyl-CoA metabolic process (GO:0035336)6.17560230
17sperm-egg recognition (GO:0035036)6.14429369
18fatty-acyl-CoA biosynthetic process (GO:0046949)6.12712542
19multicellular organism reproduction (GO:0032504)6.05149345
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.02176836
21sterol biosynthetic process (GO:0016126)5.99964003
22spermatid nucleus differentiation (GO:0007289)5.98652828
23negative regulation of inclusion body assembly (GO:0090084)5.90570972
24thrombin receptor signaling pathway (GO:0070493)5.86534483
25DNA packaging (GO:0006323)5.83296414
26spermatid development (GO:0007286)5.71532596
27binding of sperm to zona pellucida (GO:0007339)5.59601725
28astrocyte differentiation (GO:0048708)5.59008290
29reproduction (GO:0000003)5.55627459
30fatty-acyl-CoA metabolic process (GO:0035337)5.46302236
31positive regulation of endothelial cell differentiation (GO:0045603)5.39273588
32calcium ion-dependent exocytosis (GO:0017156)5.33060539
33coenzyme catabolic process (GO:0009109)5.18084571
34cell-cell recognition (GO:0009988)5.11370236
35long-chain fatty acid biosynthetic process (GO:0042759)5.10905395
36very long-chain fatty acid metabolic process (GO:0000038)5.10373006
37sexual reproduction (GO:0019953)5.01248767
38apical protein localization (GO:0045176)5.00769375
39myelination (GO:0042552)5.00202537
40myelin maintenance (GO:0043217)4.97813645
41negative regulation of skeletal muscle tissue development (GO:0048642)4.91323435
42ensheathment of neurons (GO:0007272)4.90448178
43axon ensheathment (GO:0008366)4.90448178
44thioester biosynthetic process (GO:0035384)4.90292102
45acyl-CoA biosynthetic process (GO:0071616)4.90292102
46cellular ketone body metabolic process (GO:0046950)4.77642031
47polyamine biosynthetic process (GO:0006596)4.75992751
48rRNA methylation (GO:0031167)4.66917273
49regulation of skeletal muscle cell differentiation (GO:2001014)4.60743835
50spermatogenesis (GO:0007283)4.47026649
51male gamete generation (GO:0048232)4.44938898
52adenosine receptor signaling pathway (GO:0001973)4.32984138
53ketone body metabolic process (GO:1902224)4.17819208
54phosphate ion transmembrane transport (GO:0035435)4.16851492
55protein autoprocessing (GO:0016540)4.15691860
56axonemal dynein complex assembly (GO:0070286)4.08060465
57negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.06885982
58gamete generation (GO:0007276)4.06529068
59regulation of cilium movement (GO:0003352)4.01761992
60neutrophil activation involved in immune response (GO:0002283)4.01658516
61glycerol ether metabolic process (GO:0006662)4.01298763
62regulation of inclusion body assembly (GO:0090083)3.95391711
63microtubule severing (GO:0051013)3.91902399
64tissue regeneration (GO:0042246)3.85237284
65cofactor catabolic process (GO:0051187)3.84851519
66regulation of endothelial cell differentiation (GO:0045601)3.82595084
67blood coagulation, intrinsic pathway (GO:0007597)3.82255922
68negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.74805622
69regulation of platelet activation (GO:0010543)3.72283130
70single fertilization (GO:0007338)3.71826314
71regulation of Rab GTPase activity (GO:0032313)3.69625565
72positive regulation of Rab GTPase activity (GO:0032851)3.69625565
73asymmetric protein localization (GO:0008105)3.69449128
74rRNA modification (GO:0000154)3.67577061
75ether metabolic process (GO:0018904)3.66332895
76triglyceride biosynthetic process (GO:0019432)3.65174918
77negative regulation of platelet activation (GO:0010544)3.63114084
78protein polyglutamylation (GO:0018095)3.62330728
79negative regulation of heart rate (GO:0010459)3.59989909
80amyloid precursor protein catabolic process (GO:0042987)3.59980040
81dendritic spine morphogenesis (GO:0060997)3.59266901
82creatine metabolic process (GO:0006600)3.58438302
83regulation of cholesterol biosynthetic process (GO:0045540)3.55646817
84positive regulation of oligodendrocyte differentiation (GO:0048714)3.55623726
85peptide catabolic process (GO:0043171)3.54386182
86regulation of integrin activation (GO:0033623)3.53743216
87establishment of mitochondrion localization (GO:0051654)3.52424614
88isoprenoid biosynthetic process (GO:0008299)3.51122411
89acylglycerol biosynthetic process (GO:0046463)3.47819854
90neutral lipid biosynthetic process (GO:0046460)3.47819854
91negative regulation of JUN kinase activity (GO:0043508)3.44586051
92chromatin silencing (GO:0006342)3.41808897
93regulation of platelet aggregation (GO:0090330)3.40836166
94regulation of lipoprotein metabolic process (GO:0050746)3.40753329
95protein depolymerization (GO:0051261)3.40147546
96negative regulation of norepinephrine secretion (GO:0010700)3.36052838
97protein neddylation (GO:0045116)3.34569930
98negative regulation of histone methylation (GO:0031061)3.31182164
99triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.31070597
100phosphate ion transport (GO:0006817)3.31044932
101retrograde transport, vesicle recycling within Golgi (GO:0000301)3.30428339
102thioester metabolic process (GO:0035383)3.28954457
103acyl-CoA metabolic process (GO:0006637)3.28954457
104multicellular organismal reproductive process (GO:0048609)3.28499098
105platelet aggregation (GO:0070527)3.27984113
106neuron cell-cell adhesion (GO:0007158)3.25349462
107protein targeting to Golgi (GO:0000042)3.25009325
108regulation of guanylate cyclase activity (GO:0031282)3.23773769
109purinergic nucleotide receptor signaling pathway (GO:0035590)3.23003269
110cellular biogenic amine biosynthetic process (GO:0042401)3.22029668
111phosphatidylethanolamine biosynthetic process (GO:0006646)3.21258110
112centriole replication (GO:0007099)3.20196986
113glycerophospholipid catabolic process (GO:0046475)3.18231811
114CDP-diacylglycerol biosynthetic process (GO:0016024)3.17137407
115amine biosynthetic process (GO:0009309)3.16636467
116positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.16584451
117response to lipoprotein particle (GO:0055094)3.16335874
118regulation of interleukin-13 production (GO:0032656)3.15966781
119regulation of T-helper 2 cell differentiation (GO:0045628)3.15383951
120mast cell degranulation (GO:0043303)3.13112572
121mast cell activation involved in immune response (GO:0002279)3.13112572
122establishment of protein localization to Golgi (GO:0072600)3.13008069
123cholesterol metabolic process (GO:0008203)3.11844370
124cellular anion homeostasis (GO:0030002)3.11238490
125alpha-linolenic acid metabolic process (GO:0036109)3.10025692
126positive regulation of guanylate cyclase activity (GO:0031284)3.08997810
127regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.08821370
128regulation of integrin-mediated signaling pathway (GO:2001044)3.08079852
129cellular process involved in reproduction in multicellular organism (GO:0022412)3.07906852
130actin filament capping (GO:0051693)3.06709658
131germ cell development (GO:0007281)3.06244923
132negative regulation of protein localization to cell surface (GO:2000009)3.05459850
133negative regulation of neurotransmitter transport (GO:0051589)3.05388973
134negative regulation of homotypic cell-cell adhesion (GO:0034111)3.03351638
135substantia nigra development (GO:0021762)3.02737949
136trivalent inorganic anion homeostasis (GO:0072506)3.01996267
137phosphate ion homeostasis (GO:0055062)3.01996267
138positive regulation of pseudopodium assembly (GO:0031274)3.01806145
139negative regulation of thymocyte apoptotic process (GO:0070244)3.01732409
140cortical actin cytoskeleton organization (GO:0030866)3.00619519
141acetyl-CoA metabolic process (GO:0006084)2.99582835
142Golgi to endosome transport (GO:0006895)2.98487415
143positive regulation of mast cell activation (GO:0033005)2.98371028
144endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.97684153
145estrogen biosynthetic process (GO:0006703)2.95329720
146membrane tubulation (GO:0097320)2.94551865
147glycosylceramide metabolic process (GO:0006677)2.93962382
148leukocyte migration involved in inflammatory response (GO:0002523)2.91582261
149motile cilium assembly (GO:0044458)2.90955204
150NAD biosynthetic process (GO:0009435)2.90027539
151phosphatidylethanolamine metabolic process (GO:0046337)2.89646433
152purinergic receptor signaling pathway (GO:0035587)2.88516247
153heme transport (GO:0015886)2.88106254
154cellular response to pH (GO:0071467)2.87823263
155L-phenylalanine catabolic process (GO:0006559)2.86990937
156erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.86990937
157eye photoreceptor cell differentiation (GO:0001754)2.86073832
158photoreceptor cell differentiation (GO:0046530)2.86073832
159receptor recycling (GO:0001881)2.84058165
160steroid biosynthetic process (GO:0006694)2.83387914
161long-term synaptic potentiation (GO:0060291)2.82553152
162positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80401327
163sterol metabolic process (GO:0016125)2.80355053
164lipoxygenase pathway (GO:0019372)2.79558201
165CDP-diacylglycerol metabolic process (GO:0046341)2.78460458
166fertilization (GO:0009566)2.77690505
167regulation of cholesterol metabolic process (GO:0090181)2.76166625
168positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.74856202
169negative regulation of heart contraction (GO:0045822)2.74249889
170L-amino acid import (GO:0043092)2.73711267
171response to acidic pH (GO:0010447)2.73413924
172neuron death (GO:0070997)2.71999253
173glutathione derivative biosynthetic process (GO:1901687)2.71790686
174glutathione derivative metabolic process (GO:1901685)2.71790686
175cytoskeletal anchoring at plasma membrane (GO:0007016)2.71157449
176termination of G-protein coupled receptor signaling pathway (GO:0038032)2.70533852
177alcohol biosynthetic process (GO:0046165)2.68320376
178response to redox state (GO:0051775)2.67121076
179detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.66910020
180detection of temperature stimulus involved in sensory perception (GO:0050961)2.66910020
181regulation of neuronal synaptic plasticity (GO:0048168)2.66031914
182platelet degranulation (GO:0002576)2.65793539
183G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.64910141
184negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.62693151
185protein refolding (GO:0042026)2.61759258
186homeostasis of number of cells within a tissue (GO:0048873)2.61056237
187response to dietary excess (GO:0002021)2.60600164
188protein localization to endosome (GO:0036010)2.60492880
189protein localization to vacuole (GO:0072665)2.60128338
190protein localization to lysosome (GO:0061462)2.60128338
191nerve growth factor signaling pathway (GO:0038180)2.59865512
192termination of signal transduction (GO:0023021)2.59161782
193iron coordination entity transport (GO:1901678)2.58386453
194negative regulation of neural precursor cell proliferation (GO:2000178)2.57871478
195fusion of sperm to egg plasma membrane (GO:0007342)11.9617170
196fatty acid elongation (GO:0030497)11.7252053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.16816234
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.64064923
3EZH2_22144423_ChIP-Seq_EOC_Human3.19457069
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.82721392
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.72252694
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.63775604
7GBX2_23144817_ChIP-Seq_PC3_Human2.49226400
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49083151
9TP53_16413492_ChIP-PET_HCT116_Human2.31886933
10GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.29254520
11OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.07206128
12NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.06829618
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97217117
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.96136893
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92761162
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91764489
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89020905
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86575079
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86324023
20ER_23166858_ChIP-Seq_MCF-7_Human1.86045728
21GATA2_19941826_ChIP-Seq_K562_Human1.84544039
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.82713028
23EOMES_21245162_ChIP-Seq_HESCs_Human1.82307981
24NR3C1_23031785_ChIP-Seq_PC12_Mouse1.81127387
25NANOG_20526341_ChIP-Seq_ESCs_Human1.76481816
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68445080
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.67446791
28EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.67075185
29DROSHA_22980978_ChIP-Seq_HELA_Human1.66456844
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.66093098
31PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.63194154
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62289487
33KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.61476578
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.60526968
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.60167220
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.57365623
37GATA3_21878914_ChIP-Seq_MCF-7_Human1.55909199
38GATA1_19941826_ChIP-Seq_K562_Human1.55734430
39STAT3_23295773_ChIP-Seq_U87_Human1.53802342
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46505139
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46505139
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46446664
43FUS_26573619_Chip-Seq_HEK293_Human1.46285742
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.45645772
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.45008227
46AR_25329375_ChIP-Seq_VCAP_Human1.44685285
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43983609
48SMAD4_21799915_ChIP-Seq_A2780_Human1.43803471
49STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.43583229
50SCL_19346495_ChIP-Seq_HPC-7_Human1.42754747
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42157093
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42030728
53EWS_26573619_Chip-Seq_HEK293_Human1.41457985
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41321527
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.40496703
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.39162060
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.39144251
58TCF4_23295773_ChIP-Seq_U87_Human1.38915567
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.38358147
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38262517
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.37782609
62ELK4_26923725_Chip-Seq_MESODERM_Mouse1.37639862
63VDR_22108803_ChIP-Seq_LS180_Human1.36536248
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35910966
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35838173
66RBPJ_21746931_ChIP-Seq_IB4_Human1.35050037
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34590334
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34560832
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34530250
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.32853570
71TAF2_19829295_ChIP-Seq_ESCs_Human1.32036432
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31468432
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.31053625
74SALL4_22934838_ChIP-ChIP_CD34+_Human1.30349419
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30083274
76CBP_20019798_ChIP-Seq_JUKART_Human1.30083274
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.28829179
78* SMAD4_21741376_ChIP-Seq_HESCs_Human1.28576675
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28121109
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28092018
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27518070
82SOX2_19829295_ChIP-Seq_ESCs_Human1.27129171
83NANOG_19829295_ChIP-Seq_ESCs_Human1.27129171
84ERA_21632823_ChIP-Seq_H3396_Human1.26651504
85AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26416836
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26299816
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24582118
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24555010
89RUNX_20019798_ChIP-Seq_JUKART_Human1.24335851
90CBX2_22325352_ChIP-Seq_293T-Rex_Human1.23818702
91RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23399837
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.23371529
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22590099
94OCT1_27270436_Chip-Seq_PROSTATE_Human1.22566651
95MYC_19829295_ChIP-Seq_ESCs_Human1.22272244
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21965459
97HTT_18923047_ChIP-ChIP_STHdh_Human1.21598001
98P300_19829295_ChIP-Seq_ESCs_Human1.21491035
99WT1_19549856_ChIP-ChIP_CCG9911_Human1.21181832
100TBL1_22424771_ChIP-Seq_293T_Human1.20758014
101REST_18959480_ChIP-ChIP_MESCs_Mouse1.19195750
102TAF15_26573619_Chip-Seq_HEK293_Human1.18809234
103GF1_26923725_Chip-Seq_HPCs_Mouse1.18655787
104FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17393519
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.17348030
106YY1_22570637_ChIP-Seq_MALME-3M_Human1.16620412
107GATA1_19941827_ChIP-Seq_MEL86_Mouse1.16537514
108AR_21572438_ChIP-Seq_LNCaP_Human1.16406478
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16113284
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14222153
111ERG_20517297_ChIP-Seq_VCAP_Human1.14014109
112CEBPB_22108803_ChIP-Seq_LS180_Human1.13923241
113TP63_22573176_ChIP-Seq_HFKS_Human1.13440383
114CTCF_27219007_Chip-Seq_Bcells_Human1.13135498
115NFYB_21822215_ChIP-Seq_K562_Human1.11915799
116JUN_21703547_ChIP-Seq_K562_Human1.11609783
117FOXO3_23340844_ChIP-Seq_DLD1_Human1.11258697
118ETV1_20927104_ChIP-Seq_GIST48_Human1.10391836
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10280320
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.09583088
121SPI1_23127762_ChIP-Seq_K562_Human1.09287330
122CTCF_20526341_ChIP-Seq_ESCs_Human1.08894531
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.08805076
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08580416
125CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08519073
126E2F1_20622854_ChIP-Seq_HELA_Human1.07912053
127EZH2_27304074_Chip-Seq_ESCs_Mouse1.07495197
128SMRT_27268052_Chip-Seq_Bcells_Human1.06969925
129* REST_21632747_ChIP-Seq_MESCs_Mouse1.06864577
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06855303
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06822023
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06770508
133BCOR_27268052_Chip-Seq_Bcells_Human1.06513002
134BCL6_27268052_Chip-Seq_Bcells_Human1.05880268
135PHF8_20622853_ChIP-Seq_HELA_Human1.05711965
136GATA1_19941827_ChIP-Seq_MEL_Mouse1.05614331
137SMAD3_21741376_ChIP-Seq_ESCs_Human1.05544926
138CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05274077
139NFYA_21822215_ChIP-Seq_K562_Human1.04817660
140* ARNT_22903824_ChIP-Seq_MCF-7_Human1.04439935
141GATA6_21074721_ChIP-Seq_CACO-2_Human1.04376937
142RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03856113
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03243576
144ZNF263_19887448_ChIP-Seq_K562_Human1.03039575
145NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02955875
146LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01876625
147JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01296637
148ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01047657
149STAT1_20625510_ChIP-Seq_HELA_Human1.00689355
150P300_27268052_Chip-Seq_Bcells_Human1.00345875
151TP53_18474530_ChIP-ChIP_U2OS_Human0.99301420
152HOXB7_26014856_ChIP-Seq_BT474_Human0.98800593
153PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98584498
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98574799
155VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98297527
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98276389
157YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96131405
158TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95752672
159SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95597687
160TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94968544
161TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94481840
162POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94481840
163PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94461336
164ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94415068
165CLOCK_20551151_ChIP-Seq_293T_Human0.93718335
166RNF2_27304074_Chip-Seq_ESCs_Mouse0.92852411
167IGF1R_20145208_ChIP-Seq_DFB_Human0.92793553
168KDM2B_26808549_Chip-Seq_REH_Human0.92505767
169KLF4_19829295_ChIP-Seq_ESCs_Human0.91850057
170ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91356841
171POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.89920048
172NANOG_18555785_Chip-Seq_ESCs_Mouse0.89384964
173LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89105468
174NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88452353
175EZH2_27294783_Chip-Seq_ESCs_Mouse0.87363070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.68973229
2MP0000920_abnormal_myelination4.53677926
3MP0008004_abnormal_stomach_pH4.37262220
4MP0003806_abnormal_nucleotide_metabolis4.30931587
5MP0004859_abnormal_synaptic_plasticity3.28981925
6MP0003698_abnormal_male_reproductive3.16840043
7MP0004270_analgesia3.14682434
8MP0005670_abnormal_white_adipose3.01189591
9MP0006072_abnormal_retinal_apoptosis2.97701179
10MP0004885_abnormal_endolymph2.94644808
11MP0003880_abnormal_central_pattern2.73931459
12MP0005423_abnormal_somatic_nervous2.69716504
13MP0003690_abnormal_glial_cell2.65010359
14MP0004742_abnormal_vestibular_system2.56240523
15MP0005377_hearing/vestibular/ear_phenot2.52071775
16MP0003878_abnormal_ear_physiology2.52071775
17MP0001929_abnormal_gametogenesis2.50516979
18MP0005360_urolithiasis2.42556690
19MP0002090_abnormal_vision2.38412777
20MP0000778_abnormal_nervous_system2.37641979
21MP0003634_abnormal_glial_cell2.36990790
22MP0003632_abnormal_nervous_system2.33254626
23MP0003011_delayed_dark_adaptation2.26333235
24MP0001529_abnormal_vocalization2.24652840
25MP0002132_abnormal_respiratory_system2.16759348
26MP0000678_abnormal_parathyroid_gland2.11044026
27MP0005083_abnormal_biliary_tract2.10047008
28MP0003879_abnormal_hair_cell2.09869668
29MP0000230_abnormal_systemic_arterial2.08083175
30MP0001765_abnormal_ion_homeostasis2.05632662
31MP0001905_abnormal_dopamine_level2.04052753
32MP0003329_amyloid_beta_deposits1.99870239
33MP0000465_gastrointestinal_hemorrhage1.92547609
34MP0003635_abnormal_synaptic_transmissio1.91492476
35MP0002139_abnormal_hepatobiliary_system1.89517082
36MP0002229_neurodegeneration1.88514772
37MP0005551_abnormal_eye_electrophysiolog1.87473325
38MP0003638_abnormal_response/metabolism_1.85133450
39MP0010678_abnormal_skin_adnexa1.83909488
40MP0002272_abnormal_nervous_system1.83575952
41MP0002733_abnormal_thermal_nociception1.81584361
42MP0004043_abnormal_pH_regulation1.76611261
43MP0001879_abnormal_lymphatic_vessel1.75063010
44MP0003566_abnormal_cell_adhesion1.73493749
45MP0003631_nervous_system_phenotype1.71338813
46MP0004084_abnormal_cardiac_muscle1.68657717
47MP0002064_seizures1.66493786
48MP0003656_abnormal_erythrocyte_physiolo1.65993084
49MP0001486_abnormal_startle_reflex1.65527482
50MP0002161_abnormal_fertility/fecundity1.64688549
51MP0002063_abnormal_learning/memory/cond1.64447778
52MP0000604_amyloidosis1.63099234
53MP0000003_abnormal_adipose_tissue1.62372639
54MP0005253_abnormal_eye_physiology1.61325927
55MP0001485_abnormal_pinna_reflex1.58583284
56MP0005085_abnormal_gallbladder_physiolo1.56395133
57MP0005167_abnormal_blood-brain_barrier1.50844712
58MP0002735_abnormal_chemical_nociception1.50016040
59MP0003724_increased_susceptibility_to1.48889047
60MP0008775_abnormal_heart_ventricle1.46886342
61MP0003633_abnormal_nervous_system1.43024839
62MP0009840_abnormal_foam_cell1.42020040
63MP0001968_abnormal_touch/_nociception1.39828741
64MP0002295_abnormal_pulmonary_circulatio1.38359608
65MP0001177_atelectasis1.37257630
66MP0001666_abnormal_nutrient_absorption1.34995938
67MP0005623_abnormal_meninges_morphology1.32585250
68MP0002572_abnormal_emotion/affect_behav1.32370811
69MP0008872_abnormal_physiological_respon1.29845871
70MP0002736_abnormal_nociception_after1.27820232
71MP0005409_darkened_coat_color1.26146992
72MP0005084_abnormal_gallbladder_morpholo1.25608401
73MP0004142_abnormal_muscle_tone1.25154730
74MP0009697_abnormal_copulation1.24952427
75MP0002734_abnormal_mechanical_nocicepti1.24736946
76MP0003252_abnormal_bile_duct1.24329443
77MP0000462_abnormal_digestive_system1.23365678
78MP0001970_abnormal_pain_threshold1.23355517
79MP0009745_abnormal_behavioral_response1.23148177
80MP0003172_abnormal_lysosome_physiology1.21910555
81MP0000249_abnormal_blood_vessel1.19571374
82MP0004036_abnormal_muscle_relaxation1.16427527
83MP0002882_abnormal_neuron_morphology1.15046721
84MP0000579_abnormal_nail_morphology1.12966135
85MP0005636_abnormal_mineral_homeostasis1.11731802
86MP0009053_abnormal_anal_canal1.11238553
87MP0004811_abnormal_neuron_physiology1.10819921
88MP0001346_abnormal_lacrimal_gland1.10721700
89MP0003136_yellow_coat_color1.10433803
90MP0000955_abnormal_spinal_cord1.10051882
91MP0000383_abnormal_hair_follicle1.08992173
92MP0004510_myositis1.06547091
93MP0002066_abnormal_motor_capabilities/c1.06320257
94MP0004019_abnormal_vitamin_homeostasis1.04815581
95MP0000343_altered_response_to1.02366189
96MP0005365_abnormal_bile_salt1.00362450
97MP0002234_abnormal_pharynx_morphology0.98494197
98MP0004085_abnormal_heartbeat0.98055826
99MP0001963_abnormal_hearing_physiology0.97709303
100MP0010155_abnormal_intestine_physiology0.97087256
101MP0004484_altered_response_of0.97055058
102MP0000013_abnormal_adipose_tissue0.96318639
103MP0001348_abnormal_lacrimal_gland0.96174333
104MP0005195_abnormal_posterior_eye0.95772450
105MP0001299_abnormal_eye_distance/0.95432592
106MP0003075_altered_response_to0.95319933
107MP0001502_abnormal_circadian_rhythm0.94775825
108MP0008438_abnormal_cutaneous_collagen0.93708160
109MP0004134_abnormal_chest_morphology0.92577323
110MP0002653_abnormal_ependyma_morphology0.90445823
111MP0002118_abnormal_lipid_homeostasis0.89238050
112MP0005395_other_phenotype0.88710516
113MP0000733_abnormal_muscle_development0.88291285
114MP0005332_abnormal_amino_acid0.87959111
115MP0003787_abnormal_imprinting0.87647783
116MP0003718_maternal_effect0.86620027
117MP0008875_abnormal_xenobiotic_pharmacok0.86396137
118MP0004215_abnormal_myocardial_fiber0.86187198
119MP0000647_abnormal_sebaceous_gland0.86051912
120MP0002210_abnormal_sex_determination0.85692759
121MP0005451_abnormal_body_composition0.85409371
122MP0005666_abnormal_adipose_tissue0.84666852
123MP0000015_abnormal_ear_pigmentation0.83015644
124MP0001663_abnormal_digestive_system0.82400645
125MP0000747_muscle_weakness0.80861210
126MP0000653_abnormal_sex_gland0.80343734
127MP0001849_ear_inflammation0.79749031
128MP0005535_abnormal_body_temperature0.77700400
129MP0003119_abnormal_digestive_system0.76888202
130MP0005379_endocrine/exocrine_gland_phen0.76409994
131MP0003453_abnormal_keratinocyte_physiol0.75551779
132MP0001145_abnormal_male_reproductive0.75462150
133MP0008874_decreased_physiological_sensi0.75349131
134MP0002152_abnormal_brain_morphology0.74719389
135MP0003186_abnormal_redox_activity0.73770081
136MP0002133_abnormal_respiratory_system0.73309399
137MP0005388_respiratory_system_phenotype0.73309399
138MP0004947_skin_inflammation0.71894627
139MP0004381_abnormal_hair_follicle0.68569680
140MP0005391_vision/eye_phenotype0.68349285
141MP0001851_eye_inflammation0.67853858
142MP0008569_lethality_at_weaning0.67715899
143MP0005386_behavior/neurological_phenoty0.67620740
144MP0004924_abnormal_behavior0.67620740
145MP0003183_abnormal_peptide_metabolism0.67285309
146MP0005310_abnormal_salivary_gland0.66460419
147MP0009765_abnormal_xenobiotic_induced0.66236268
148MP0001664_abnormal_digestion0.66115788
149MP0005058_abnormal_lysosome_morphology0.65770289
150MP0009780_abnormal_chondrocyte_physiolo0.65447159
151MP0003303_peritoneal_inflammation0.64844777
152MP0010329_abnormal_lipoprotein_level0.64271223
153MP0003091_abnormal_cell_migration0.62611450
154MP0005410_abnormal_fertilization0.61887137
155MP0009642_abnormal_blood_homeostasis0.61286276
156MP0002067_abnormal_sensory_capabilities0.61137351
157MP0000534_abnormal_ureter_morphology0.60495634
158MP0006276_abnormal_autonomic_nervous0.60141191
159MP0005501_abnormal_skin_physiology0.59990411
160MP0009046_muscle_twitch0.59868073
161MP0000639_abnormal_adrenal_gland0.59023159
162MP0005166_decreased_susceptibility_to0.56896677
163MP0009764_decreased_sensitivity_to0.55882917
164MP0005646_abnormal_pituitary_gland0.55843105
165MP0001533_abnormal_skeleton_physiology0.55301271
166MP0005381_digestive/alimentary_phenotyp0.53902503
167MP0005620_abnormal_muscle_contractility0.53796839
168MP0000467_abnormal_esophagus_morphology0.52651351
169MP0002127_abnormal_cardiovascular_syste0.52630042
170MP0004264_abnormal_extraembryonic_tissu0.51115542
171MP0005165_increased_susceptibility_to0.49214827
172MP0008877_abnormal_DNA_methylation0.48318860
173MP0000026_abnormal_inner_ear0.47916495
174MP0002282_abnormal_trachea_morphology0.47370467
175MP0005023_abnormal_wound_healing0.46892662
176MP0003866_abnormal_defecation0.45406895

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.66900291
2Increased mean platelet volume (HP:0011877)8.37033260
3Menorrhagia (HP:0000132)8.26662015
4Abnormal platelet volume (HP:0011876)7.70454838
5Petechiae (HP:0000967)7.33792109
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.97951277
7Degeneration of the lateral corticospinal tracts (HP:0002314)6.97951277
8Purpura (HP:0000979)6.32715019
9Insidious onset (HP:0003587)5.87091811
10Termporal pattern (HP:0011008)5.87091811
11Abnormality of the corticospinal tract (HP:0002492)5.84538289
12Severe visual impairment (HP:0001141)5.82747981
13Epistaxis (HP:0000421)5.45633509
14Thin bony cortex (HP:0002753)5.28852561
15Gingival bleeding (HP:0000225)4.72694571
16Neurofibrillary tangles (HP:0002185)4.66589955
17Hypophosphatemic rickets (HP:0004912)4.58586887
18Enlarged epiphyses (HP:0010580)4.41580264
19Cerebral inclusion bodies (HP:0100314)4.30710212
20Acanthocytosis (HP:0001927)4.23419391
21Abnormal platelet function (HP:0011869)3.82763497
22Impaired platelet aggregation (HP:0003540)3.82763497
23Poikilocytosis (HP:0004447)3.75687102
24Male infertility (HP:0003251)3.68498264
25Dynein arm defect of respiratory motile cilia (HP:0012255)3.66399151
26Absent/shortened dynein arms (HP:0200106)3.66399151
27Widely patent fontanelles and sutures (HP:0004492)3.58910226
28Spastic gait (HP:0002064)3.58250137
29Supranuclear gaze palsy (HP:0000605)3.58042284
30Delayed epiphyseal ossification (HP:0002663)3.57834324
31Abnormal spermatogenesis (HP:0008669)3.52767772
32Abnormal ciliary motility (HP:0012262)3.47933066
33Urinary urgency (HP:0000012)3.37846280
34Decreased central vision (HP:0007663)3.31718515
35Hypoplastic ischia (HP:0003175)3.30764288
36Generalized aminoaciduria (HP:0002909)3.29600051
37Increased serum pyruvate (HP:0003542)3.25072466
38Abnormality of glycolysis (HP:0004366)3.25072466
39Azoospermia (HP:0000027)3.24490306
40Abnormality of the costochondral junction (HP:0000919)3.24112717
41Infertility (HP:0000789)3.23749782
42Attenuation of retinal blood vessels (HP:0007843)3.03996725
43Urinary bladder sphincter dysfunction (HP:0002839)3.01759651
44Onion bulb formation (HP:0003383)3.00211758
45Abnormal respiratory motile cilium physiology (HP:0012261)3.00024247
46Dyschromatopsia (HP:0007641)2.97596671
47Facial shape deformation (HP:0011334)2.96368594
48Potter facies (HP:0002009)2.96368594
49Parakeratosis (HP:0001036)2.96277987
50Abnormal pupillary function (HP:0007686)2.96062039
51Hyperlipoproteinemia (HP:0010980)2.94773197
52Abnormal respiratory epithelium morphology (HP:0012253)2.94657042
53Abnormal respiratory motile cilium morphology (HP:0005938)2.94657042
54Myokymia (HP:0002411)2.93841124
55Deep venous thrombosis (HP:0002625)2.93342655
56Spastic tetraparesis (HP:0001285)2.92678813
57Action tremor (HP:0002345)2.92388621
58Spontaneous hematomas (HP:0007420)2.92290610
59Bony spicule pigmentary retinopathy (HP:0007737)2.89334288
60Abnormality of the ischium (HP:0003174)2.85331775
61Cortical dysplasia (HP:0002539)2.83678689
62Flat occiput (HP:0005469)2.81216304
63Upper limb muscle weakness (HP:0003484)2.77681006
64Intention tremor (HP:0002080)2.73983119
65Abnormal auditory evoked potentials (HP:0006958)2.73433161
66Retinal dysplasia (HP:0007973)2.67444556
67Choroideremia (HP:0001139)2.61259508
68Leukodystrophy (HP:0002415)2.60806828
69Abnormal rod and cone electroretinograms (HP:0008323)2.60768731
70Intrahepatic cholestasis (HP:0001406)2.57326560
71Infantile muscular hypotonia (HP:0008947)2.54562686
72Dysmetria (HP:0001310)2.52562867
73Sensory axonal neuropathy (HP:0003390)2.51287409
74Bell-shaped thorax (HP:0001591)2.48618977
75Septate vagina (HP:0001153)2.45678747
76Morphological abnormality of the pyramidal tract (HP:0002062)2.43214081
77Nasal polyposis (HP:0100582)2.38813577
78Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.38566048
79Peripheral hypomyelination (HP:0007182)2.36082634
80Axonal loss (HP:0003447)2.35160468
81Bruising susceptibility (HP:0000978)2.33348612
82Clonus (HP:0002169)2.30909937
83Agitation (HP:0000713)2.30716458
84Resting tremor (HP:0002322)2.26812837
85Tibial bowing (HP:0002982)2.26583850
86Ankle clonus (HP:0011448)2.16598655
87Slow saccadic eye movements (HP:0000514)2.16564485
88Lower limb muscle weakness (HP:0007340)2.13820392
89Impaired vibration sensation in the lower limbs (HP:0002166)2.12443494
90Psychosis (HP:0000709)2.12093335
91Autoamputation (HP:0001218)2.11587516
92Postural tremor (HP:0002174)2.10760241
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10061679
94Xanthomatosis (HP:0000991)2.09588070
95Asymmetric septal hypertrophy (HP:0001670)2.09309704
96Hepatosplenomegaly (HP:0001433)2.08540693
97Abnormality of the labia minora (HP:0012880)2.07041566
98EEG with generalized epileptiform discharges (HP:0011198)2.07010603
99Hypsarrhythmia (HP:0002521)2.06627974
100Abnormality of the vasculature of the conjunctiva (HP:0008054)2.05212207
101Scanning speech (HP:0002168)2.04561116
102Congenital sensorineural hearing impairment (HP:0008527)2.03685352
103Hyperthyroidism (HP:0000836)2.02907095
104Buphthalmos (HP:0000557)2.02346841
105Rickets (HP:0002748)2.00437007
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.99846599
107Epileptiform EEG discharges (HP:0011182)1.99187148
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98186522
109Paralysis (HP:0003470)1.98128052
110Cerebral hemorrhage (HP:0001342)1.96681276
111Nausea (HP:0002018)1.96317093
112Abnormality of the common coagulation pathway (HP:0010990)1.96172354
113Optic nerve hypoplasia (HP:0000609)1.94618298
114Macroorchidism (HP:0000053)1.94544330
115Choreoathetosis (HP:0001266)1.94487867
116Abnormal urine output (HP:0012590)1.93885076
117Coronal craniosynostosis (HP:0004440)1.92980029
118Abnormality of macular pigmentation (HP:0008002)1.92550510
119Rhinitis (HP:0012384)1.92460586
120Portal hypertension (HP:0001409)1.91890290
121Wide cranial sutures (HP:0010537)1.91774853
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90934264
123Absent epiphyses (HP:0010577)1.90934264
124Renal Fanconi syndrome (HP:0001994)1.90108709
125Femoral bowing (HP:0002980)1.89695169
126Abnormality of the nasal mucosa (HP:0000433)1.89476062
127Cerebral hypomyelination (HP:0006808)1.88988596
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88576292
129Abnormality of lateral ventricle (HP:0030047)1.88347054
130Anteriorly placed anus (HP:0001545)1.84013301
131Glycosuria (HP:0003076)1.82518676
132Abnormality of urine glucose concentration (HP:0011016)1.82518676
133Unilateral renal agenesis (HP:0000122)1.82137214
134Conjunctival telangiectasia (HP:0000524)1.80414269
135Hyporeflexia of lower limbs (HP:0002600)1.79906917
136Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79322241
137Conjugated hyperbilirubinemia (HP:0002908)1.78769939
138Abnormal urine phosphate concentration (HP:0012599)1.76701660
139Morphological abnormality of the inner ear (HP:0011390)1.76100549
140Progressive sensorineural hearing impairment (HP:0000408)1.75033948
141Tetany (HP:0001281)1.74340795
142Hammertoe (HP:0001765)1.74105601
143Abnormality of potassium homeostasis (HP:0011042)1.73871394
144Abnormality of renal excretion (HP:0011036)1.73436178
145Hypokalemia (HP:0002900)1.73139447
146Hyperkalemia (HP:0002153)1.72784304
147Dysdiadochokinesis (HP:0002075)1.72699837
148Poor speech (HP:0002465)1.72646316
149Abnormality of the pubic bones (HP:0003172)1.72298709
150Foot dorsiflexor weakness (HP:0009027)1.71780761
151Congenital ichthyosiform erythroderma (HP:0007431)1.71444182
152Difficulty walking (HP:0002355)1.71325156
153Excessive salivation (HP:0003781)1.70784770
154Drooling (HP:0002307)1.70784770
155Segmental peripheral demyelination/remyelination (HP:0003481)1.70730083
156Abnormality of sodium homeostasis (HP:0010931)1.69739944
157Abnormality of the hepatic vasculature (HP:0006707)1.69545533
158Cone-rod dystrophy (HP:0000548)1.68611360
159Hydroureter (HP:0000072)1.68253793
160Hyperventilation (HP:0002883)1.68020241
161CNS hypomyelination (HP:0003429)1.67995198
162Akinesia (HP:0002304)1.67721481
163Clumsiness (HP:0002312)1.67257934
164Stenosis of the external auditory canal (HP:0000402)1.66450646
165Partial agenesis of the corpus callosum (HP:0001338)1.66391921
166Increased density of long bones (HP:0006392)1.66384772
167Metabolic alkalosis (HP:0200114)1.65700065
168Shallow orbits (HP:0000586)1.65682602
169Hyponatremia (HP:0002902)1.65037145
170Postnatal microcephaly (HP:0005484)1.64576194
171Focal segmental glomerulosclerosis (HP:0000097)1.63646793
172Glomerulosclerosis (HP:0000096)1.63592963
173Postural instability (HP:0002172)1.62637505
174Muscle fiber atrophy (HP:0100295)1.62572805
175Aplasia/Hypoplasia of the earlobes (HP:0009906)1.62394606
176Protuberant abdomen (HP:0001538)1.62043258
177Peritonitis (HP:0002586)1.61455575
178Urinary incontinence (HP:0000020)1.61046724
179Abnormality of the epiphysis of the femoral head (HP:0010574)1.60679791
180Progressive cerebellar ataxia (HP:0002073)1.60449153
181T lymphocytopenia (HP:0005403)1.59676394
182Hypobetalipoproteinemia (HP:0003563)1.59269963
183Global brain atrophy (HP:0002283)1.57740206
184Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.57440194
185Restlessness (HP:0000711)1.55659414
186Ventricular tachycardia (HP:0004756)1.55112791
187Abnormal drinking behavior (HP:0030082)1.53392709
188Polydipsia (HP:0001959)1.53392709
189Polyuria (HP:0000103)1.52457333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB15.28463106
2PLK45.19534169
3INSRR4.72283143
4DDR24.69250586
5MAP4K24.32416248
6MAP3K134.29973828
7PBK4.22150135
8STK393.84090427
9TESK13.70602822
10RIPK43.26992153
11MST43.26570323
12ACVR1B2.74192827
13MYLK2.71245753
14BMX2.66782998
15MAPKAPK52.54322761
16PTK2B2.49788435
17FGFR22.24425262
18MAP3K42.21339589
19UHMK12.18105693
20WNK42.15319803
21WNK12.06537296
22MARK12.04897609
23PKN12.00789609
24ALK1.92241807
25PRPF4B1.87714051
26STK381.64757395
27TEC1.59388743
28TNIK1.57628959
29STK38L1.57493677
30KSR21.57091630
31MAP3K21.56317540
32NTRK31.47687935
33FGR1.46591183
34STK31.44450513
35EIF2AK11.44305106
36BMPR1B1.41719639
37CSNK1A1L1.41116878
38CSNK1G31.39759482
39SGK4941.35550802
40SGK2231.35550802
41TESK21.32268861
42OXSR11.31634622
43GRK51.31480639
44LMTK21.27847112
45BTK1.27840337
46GRK61.26407777
47MAP3K91.25966921
48CLK11.21729678
49BCR1.19885754
50PAK61.18397564
51MAPK151.16506939
52PRKG21.15354699
53PRKCQ1.13360199
54MAP3K141.12797615
55CSNK1G11.10661811
56PDPK11.10457708
57PDK11.09332018
58SYK1.09080085
59CSNK1G21.06163158
60DYRK21.03675632
61PNCK1.03518551
62MAP2K71.01775646
63TAOK30.99354134
64MST1R0.98292528
65CSF1R0.97756331
66EPHA40.97593065
67CAMK1G0.97174859
68DYRK1B0.95186153
69LRRK20.94204926
70MKNK10.90738494
71CDK50.84870017
72PAK30.81759031
73ILK0.81493124
74MARK30.79185568
75STK240.78318988
76TRIM280.78176854
77CDK150.74730103
78MAP2K40.74580138
79CAMK1D0.72494637
80PRKD30.72409943
81NTRK20.72370720
82MAP3K70.71733216
83PAK10.70664473
84NTRK10.70024133
85PRKCH0.67982340
86CDK180.67908621
87ROCK10.66540723
88CDK140.66222710
89PRKD10.64238121
90ARAF0.62346682
91ADRBK20.61954330
92RET0.61952973
93EPHB20.61538504
94EGFR0.61303847
95CDK70.61241207
96ROCK20.60554131
97ZAP700.59442624
98BRSK20.58200042
99MAPKAPK30.57405851
100CDK120.56550255
101FER0.55935028
102CAMK10.55776884
103MINK10.54693937
104CHEK20.54531843
105STK100.53956677
106CDK11A0.53763338
107BMPR20.52757903
108TLK10.52644951
109NUAK10.51117060
110CSNK1D0.50489156
111STK110.49327093
112MAP3K60.48431972
113MET0.48367320
114PLK20.48276295
115BRD40.48257661
116PIK3CG0.47924973
117BUB10.46636014
118TTK0.46410035
119CSNK1E0.45362403
120HIPK20.44817588
121NEK60.44601140
122PRKCG0.44584339
123WNK30.43888192
124MAP2K10.43510582
125DAPK30.42935742
126SGK10.42555057
127MAPK120.42252123
128FES0.41684040
129MOS0.41201010
130CAMK2A0.40425044
131MARK20.40416041
132TTN0.39919362
133LATS20.38700365
134CAMKK10.38393738
135TYRO30.37472192
136MAPK100.37153529
137PRKACB0.36823017
138MTOR0.36503870
139PTK60.36327710
140MAPK130.36319149
141SIK10.35769716
142GSK3A0.35761002
143PRKCB0.35747723
144CHEK10.35190920
145CAMK2B0.35180277
146HCK0.35154957
147PRKG10.34306474
148CAMKK20.34239649
149ERBB20.34168252
150DAPK20.32910937
151IKBKB0.32060768
152PLK30.31087891
153LYN0.30972027
154PRKCA0.29019786
155BRSK10.27871618
156MAP3K110.27220755
157ADRBK10.26751558
158TNK20.25416280
159PRKACG0.25351749
160PAK20.24311535
161DYRK30.22773217
162SRC0.21499585
163MAP3K10.21342440
164PRKAA20.19730311
165MAP3K80.18913637
166MATK0.18337877
167PRKCD0.17753447
168PRKCE0.16900966
169FYN0.15658863
170BRAF0.14104532

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.38076235
2Fatty acid elongation_Homo sapiens_hsa000625.39870537
3Steroid biosynthesis_Homo sapiens_hsa001004.73710892
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010404.28585604
5Platelet activation_Homo sapiens_hsa046113.81866684
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.49875989
7Ether lipid metabolism_Homo sapiens_hsa005652.72500423
8Olfactory transduction_Homo sapiens_hsa047402.70813780
9Fatty acid biosynthesis_Homo sapiens_hsa000612.60408074
10Butanoate metabolism_Homo sapiens_hsa006502.47977507
11ECM-receptor interaction_Homo sapiens_hsa045122.18899221
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93374837
13Renin-angiotensin system_Homo sapiens_hsa046141.93047849
14Sulfur metabolism_Homo sapiens_hsa009201.89045985
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.88425774
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.84299640
17Fatty acid metabolism_Homo sapiens_hsa012121.79659741
18Arachidonic acid metabolism_Homo sapiens_hsa005901.73032318
19Linoleic acid metabolism_Homo sapiens_hsa005911.71308422
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63621666
21Arginine and proline metabolism_Homo sapiens_hsa003301.62249540
22Nitrogen metabolism_Homo sapiens_hsa009101.57045294
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.51738866
24Pancreatic secretion_Homo sapiens_hsa049721.47429692
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46264020
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43977980
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42778746
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34915898
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33962203
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32192852
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29291487
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21476943
33Protein digestion and absorption_Homo sapiens_hsa049741.19618084
34Glutamatergic synapse_Homo sapiens_hsa047241.19604651
35Allograft rejection_Homo sapiens_hsa053301.17610357
36Propanoate metabolism_Homo sapiens_hsa006401.17026362
37GABAergic synapse_Homo sapiens_hsa047271.14433693
38Starch and sucrose metabolism_Homo sapiens_hsa005001.14325906
39Histidine metabolism_Homo sapiens_hsa003401.14144026
40Graft-versus-host disease_Homo sapiens_hsa053321.13582988
41Dorso-ventral axis formation_Homo sapiens_hsa043201.12862831
42Autoimmune thyroid disease_Homo sapiens_hsa053201.11304032
43Vitamin digestion and absorption_Homo sapiens_hsa049771.10545609
44Hematopoietic cell lineage_Homo sapiens_hsa046401.07416131
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06168856
46Retinol metabolism_Homo sapiens_hsa008301.04094160
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98564998
48Alcoholism_Homo sapiens_hsa050340.96836902
49Chemokine signaling pathway_Homo sapiens_hsa040620.96074884
50Fatty acid degradation_Homo sapiens_hsa000710.94950674
51Calcium signaling pathway_Homo sapiens_hsa040200.92147626
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91916753
53Chemical carcinogenesis_Homo sapiens_hsa052040.91527631
54Pyruvate metabolism_Homo sapiens_hsa006200.91406750
55Long-term depression_Homo sapiens_hsa047300.91259547
56Glutathione metabolism_Homo sapiens_hsa004800.89304364
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87728921
58Type II diabetes mellitus_Homo sapiens_hsa049300.87477784
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86966764
60Circadian entrainment_Homo sapiens_hsa047130.85925661
61Peroxisome_Homo sapiens_hsa041460.85720867
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85493982
63Taste transduction_Homo sapiens_hsa047420.84553228
64Arginine biosynthesis_Homo sapiens_hsa002200.83790660
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.83570476
66Ovarian steroidogenesis_Homo sapiens_hsa049130.83126766
67Renal cell carcinoma_Homo sapiens_hsa052110.82143620
68Type I diabetes mellitus_Homo sapiens_hsa049400.81761210
69Long-term potentiation_Homo sapiens_hsa047200.79425719
70Tryptophan metabolism_Homo sapiens_hsa003800.78816043
71Collecting duct acid secretion_Homo sapiens_hsa049660.74889108
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73004267
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.72930564
74Lysine degradation_Homo sapiens_hsa003100.72412437
75Synaptic vesicle cycle_Homo sapiens_hsa047210.72302660
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72184620
77Antigen processing and presentation_Homo sapiens_hsa046120.71571412
78Dopaminergic synapse_Homo sapiens_hsa047280.70218179
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70144307
80Cholinergic synapse_Homo sapiens_hsa047250.68857498
81Phototransduction_Homo sapiens_hsa047440.68270025
82Mineral absorption_Homo sapiens_hsa049780.67775494
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67030258
84Serotonergic synapse_Homo sapiens_hsa047260.66226658
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62337810
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62052648
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61648938
88Viral myocarditis_Homo sapiens_hsa054160.61162746
89Morphine addiction_Homo sapiens_hsa050320.61092165
90beta-Alanine metabolism_Homo sapiens_hsa004100.60436729
91Non-small cell lung cancer_Homo sapiens_hsa052230.58190390
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57167001
93cAMP signaling pathway_Homo sapiens_hsa040240.52884206
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52182634
95Axon guidance_Homo sapiens_hsa043600.52174068
96Renin secretion_Homo sapiens_hsa049240.51916263
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51722030
98Systemic lupus erythematosus_Homo sapiens_hsa053220.50512281
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49846955
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.49039524
101Focal adhesion_Homo sapiens_hsa045100.48787356
102Fat digestion and absorption_Homo sapiens_hsa049750.47590422
103GnRH signaling pathway_Homo sapiens_hsa049120.47302722
104Gastric acid secretion_Homo sapiens_hsa049710.45837165
105Bile secretion_Homo sapiens_hsa049760.45656910
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.45547858
107Nicotine addiction_Homo sapiens_hsa050330.45211806
108Inositol phosphate metabolism_Homo sapiens_hsa005620.44479324
109Caffeine metabolism_Homo sapiens_hsa002320.44437525
110Rap1 signaling pathway_Homo sapiens_hsa040150.44394612
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44134516
112Glycerolipid metabolism_Homo sapiens_hsa005610.44015135
113Oxidative phosphorylation_Homo sapiens_hsa001900.42941627
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42516025
115Gap junction_Homo sapiens_hsa045400.41987371
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.41409360
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.41138931
118Alzheimers disease_Homo sapiens_hsa050100.41131298
119Cocaine addiction_Homo sapiens_hsa050300.40138298
120Vibrio cholerae infection_Homo sapiens_hsa051100.39887877
121Ras signaling pathway_Homo sapiens_hsa040140.39409327
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.39293478
123Glioma_Homo sapiens_hsa052140.39246175
124ABC transporters_Homo sapiens_hsa020100.38940986
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38802274
126Pancreatic cancer_Homo sapiens_hsa052120.38442023
127Tight junction_Homo sapiens_hsa045300.38309170
128Complement and coagulation cascades_Homo sapiens_hsa046100.37960207
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37916061
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37907972
131PPAR signaling pathway_Homo sapiens_hsa033200.37273690
132Estrogen signaling pathway_Homo sapiens_hsa049150.36324910
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36281930
134Purine metabolism_Homo sapiens_hsa002300.35373259
135Choline metabolism in cancer_Homo sapiens_hsa052310.35317203
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35236820
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34942993
138Vitamin B6 metabolism_Homo sapiens_hsa007500.32065823
139B cell receptor signaling pathway_Homo sapiens_hsa046620.30107500
140Oxytocin signaling pathway_Homo sapiens_hsa049210.28670135
141Salivary secretion_Homo sapiens_hsa049700.28118213
142Prion diseases_Homo sapiens_hsa050200.27689019
143Amphetamine addiction_Homo sapiens_hsa050310.27493993
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27335976
145Insulin secretion_Homo sapiens_hsa049110.26582942
146ErbB signaling pathway_Homo sapiens_hsa040120.26528184
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26258627
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25867859
149Tyrosine metabolism_Homo sapiens_hsa003500.25673918
150Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25310724
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25001164
152VEGF signaling pathway_Homo sapiens_hsa043700.24691283
153Endocytosis_Homo sapiens_hsa041440.24375449

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »