GLRX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to zinc ion (GO:0071294)5.02788416
2response to peptidoglycan (GO:0032494)4.77856666
3neutrophil activation involved in immune response (GO:0002283)4.75847702
4respiratory burst (GO:0045730)4.48439630
5hydrogen peroxide biosynthetic process (GO:0050665)4.47093617
6reactive oxygen species biosynthetic process (GO:1903409)4.38949912
7positive regulation by symbiont of host defense response (GO:0052509)4.18267295
8modulation by symbiont of host defense response (GO:0052031)4.18267295
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18267295
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18267295
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.18267295
12modulation by symbiont of host immune response (GO:0052553)4.18267295
13immunoglobulin mediated immune response (GO:0016064)4.03422194
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00294687
15positive regulation of gamma-delta T cell activation (GO:0046645)3.68550644
16cellular extravasation (GO:0045123)3.65814405
17leukocyte aggregation (GO:0070486)3.61782139
18killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.60472730
19disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.60472730
20cellular response to cadmium ion (GO:0071276)3.53617759
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48803547
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48803547
23negative regulation of cell killing (GO:0031342)3.48516679
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48516679
25production of molecular mediator involved in inflammatory response (GO:0002532)3.48167312
26positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.43559898
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.41353040
28positive regulation of interferon-alpha production (GO:0032727)3.37956243
29superoxide anion generation (GO:0042554)3.29725742
30regulation of interferon-beta biosynthetic process (GO:0045357)3.27399957
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25678808
32response to host immune response (GO:0052572)3.25678808
33positive regulation of chemokine biosynthetic process (GO:0045080)3.25178865
34regulation of interferon-alpha production (GO:0032647)3.24363474
35cytidine metabolic process (GO:0046087)3.21073817
36cytidine catabolic process (GO:0006216)3.21073817
37cytidine deamination (GO:0009972)3.21073817
38neutrophil mediated immunity (GO:0002446)3.20093529
39disruption of cells of other organism (GO:0044364)3.17571261
40killing of cells of other organism (GO:0031640)3.17571261
41positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.17166589
42positive regulation of mast cell activation (GO:0033005)3.15209836
43macrophage activation involved in immune response (GO:0002281)3.12695269
44B cell mediated immunity (GO:0019724)3.09171443
45lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06712055
46regulation of chemokine biosynthetic process (GO:0045073)3.06404774
47response to fungus (GO:0009620)3.06328624
48granulocyte activation (GO:0036230)3.06166591
49positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.03101755
50antigen processing and presentation of endogenous antigen (GO:0019883)3.02226942
51neutrophil activation (GO:0042119)3.01596842
52leukocyte mediated cytotoxicity (GO:0001909)3.01021745
53detection of molecule of bacterial origin (GO:0032490)3.00887708
54response to interferon-beta (GO:0035456)2.97916246
55response to host (GO:0075136)2.95302311
56response to host defenses (GO:0052200)2.95302311
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95302311
58cellular response to type I interferon (GO:0071357)2.94934627
59type I interferon signaling pathway (GO:0060337)2.94934627
60detection of other organism (GO:0098543)2.92401642
61aldehyde catabolic process (GO:0046185)2.91734793
62regulation of B cell receptor signaling pathway (GO:0050855)2.91460034
63T-helper 1 type immune response (GO:0042088)2.89139610
64response to type I interferon (GO:0034340)2.89131117
65negative regulation of myeloid cell apoptotic process (GO:0033033)2.87315567
66regulation of T cell tolerance induction (GO:0002664)2.85946983
67positive regulation of interleukin-1 secretion (GO:0050716)2.84847783
68regulation of mast cell activation (GO:0033003)2.83273684
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81443669
70modulation of growth of symbiont involved in interaction with host (GO:0044144)2.81424708
71regulation of growth of symbiont in host (GO:0044126)2.81424708
72negative regulation of growth of symbiont in host (GO:0044130)2.81424708
73negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.81424708
74regulation of cytokine secretion involved in immune response (GO:0002739)2.81133256
75cellular response to interferon-gamma (GO:0071346)2.81088581
76pyrimidine ribonucleoside catabolic process (GO:0046133)2.80689820
77defense response to fungus (GO:0050832)2.80430465
78neutrophil chemotaxis (GO:0030593)2.79627296
79regulation of antigen processing and presentation (GO:0002577)2.78866368
80positive regulation of interleukin-1 beta secretion (GO:0050718)2.78354232
81positive regulation of mast cell activation involved in immune response (GO:0033008)2.77709193
82positive regulation of mast cell degranulation (GO:0043306)2.77709193
83regulation of tolerance induction (GO:0002643)2.76736344
84cell killing (GO:0001906)2.75606173
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.74007000
86response to interferon-gamma (GO:0034341)2.73357829
87myeloid cell activation involved in immune response (GO:0002275)2.73302149
88neutrophil migration (GO:1990266)2.72122182
89regulation of mast cell degranulation (GO:0043304)2.71034908
90microglial cell activation (GO:0001774)2.70696626
91interferon-gamma-mediated signaling pathway (GO:0060333)2.70605724
92actin nucleation (GO:0045010)2.70236146
93regulation of dendritic cell antigen processing and presentation (GO:0002604)2.69746529
94regulation of T cell mediated cytotoxicity (GO:0001914)2.68979370
95detection of bacterium (GO:0016045)2.66243551
96response to interferon-alpha (GO:0035455)2.64857639
97regulation of interleukin-1 beta secretion (GO:0050706)2.64716051
98regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.63323217
99phagosome maturation (GO:0090382)2.62877287
100regulation of alpha-beta T cell proliferation (GO:0046640)2.62313725
101signal peptide processing (GO:0006465)2.61850908
102lymphocyte chemotaxis (GO:0048247)2.60655818
103cellular response to interferon-beta (GO:0035458)2.59137520
104angiotensin maturation (GO:0002003)2.58576870
105regulation of interleukin-1 secretion (GO:0050704)2.58297473
106antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.57609331
107sequestering of metal ion (GO:0051238)2.57518651
108triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.57241551
109positive regulation of T cell mediated cytotoxicity (GO:0001916)2.56750282
110regulation of T-helper 1 cell differentiation (GO:0045625)2.55985965
111hydrogen peroxide metabolic process (GO:0042743)2.55876770
112detection of biotic stimulus (GO:0009595)2.55047481
113negative regulation of cytokine production involved in immune response (GO:0002719)2.54471772
114granulocyte chemotaxis (GO:0071621)2.54178167
115negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.53193106
116mast cell activation (GO:0045576)2.52545373
117regulation of hypersensitivity (GO:0002883)2.51589928
118negative regulation of viral genome replication (GO:0045071)2.51382146
119natural killer cell mediated immunity (GO:0002228)2.51369674
120natural killer cell mediated cytotoxicity (GO:0042267)2.51369674
121positive regulation of antigen processing and presentation (GO:0002579)2.51126365
122negative regulation of interleukin-12 production (GO:0032695)2.49960911
123myeloid leukocyte mediated immunity (GO:0002444)2.49885481
124regulation of mast cell activation involved in immune response (GO:0033006)2.49098997
125positive regulation of tolerance induction (GO:0002645)2.48816389
126DNA deamination (GO:0045006)2.48167280
127granulocyte migration (GO:0097530)2.45661130
128positive regulation of interferon-beta production (GO:0032728)2.44302196
129defense response to protozoan (GO:0042832)2.44195433
130regulation of gamma-delta T cell activation (GO:0046643)2.43417147
131positive regulation of defense response to virus by host (GO:0002230)2.42597333
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.42540092
133regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.42343876
134regulation of interleukin-8 biosynthetic process (GO:0045414)2.41841905
135regulation of heterotypic cell-cell adhesion (GO:0034114)2.41560976
136phospholipid efflux (GO:0033700)2.41502871
137regulation of interleukin-8 secretion (GO:2000482)2.41103324
138detection of external biotic stimulus (GO:0098581)2.40565494
139regulation of inflammatory response to antigenic stimulus (GO:0002861)2.39906395
140eosinophil chemotaxis (GO:0048245)2.39847533
141positive regulation of toll-like receptor signaling pathway (GO:0034123)2.38988718
142positive regulation of lymphocyte migration (GO:2000403)2.38468691
143positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.38361049
144cellular response to exogenous dsRNA (GO:0071360)2.38304331
145antigen processing and presentation via MHC class Ib (GO:0002475)2.37910835
146positive regulation of interleukin-1 production (GO:0032732)2.36770510
147response to zinc ion (GO:0010043)2.36596395
148positive regulation of monocyte chemotaxis (GO:0090026)2.35100448
149positive regulation of interleukin-1 beta production (GO:0032731)2.34560143
150regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.31887225
151myeloid dendritic cell differentiation (GO:0043011)2.31822896
152regulation of lymphocyte migration (GO:2000401)2.31753775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.71119440
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.28047066
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.08724224
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.54586750
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14836330
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.12936838
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.12198646
8* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.03342528
9* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.02595277
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.99633630
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92216364
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.49647433
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.47446319
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.39636557
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.39444429
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.34365963
17* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32065118
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.30345010
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26752120
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.24309927
21* SPI1_23547873_ChIP-Seq_NB4_Human2.19883869
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17092915
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.14956401
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12421135
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12315840
26* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08576554
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06436677
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02182842
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95771256
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93658195
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86376252
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.76237056
33* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74768264
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73289461
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73251835
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69327780
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64251673
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59978010
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58170922
40CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56763545
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.54078883
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.51108280
43CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.48101081
44CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.46403876
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46138979
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44863121
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.43812511
48MYB_26560356_Chip-Seq_TH2_Human1.43376646
49* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42387881
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41593200
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40684114
52PU_27001747_Chip-Seq_BMDM_Mouse1.40437756
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.37195791
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35811507
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33919693
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32377299
57VDR_24763502_ChIP-Seq_THP-1_Human1.31581514
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30713971
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30100295
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29145216
61GATA1_22025678_ChIP-Seq_K562_Human1.28339165
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28160025
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27873377
64SCL_19346495_ChIP-Seq_HPC-7_Human1.27147735
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26983727
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23988214
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.23449883
68GATA3_26560356_Chip-Seq_TH2_Human1.20494504
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.18513860
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16359721
71JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15630002
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.13897993
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13315438
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12182350
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11992174
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11900880
77SPI1_23127762_ChIP-Seq_K562_Human1.11663526
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11524667
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11505851
80STAT1_20625510_ChIP-Seq_HELA_Human1.09957850
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09787337
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09300235
83* MYB_26560356_Chip-Seq_TH1_Human1.07426023
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06292625
85MAF_26560356_Chip-Seq_TH1_Human1.05141702
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.01484610
87VDR_21846776_ChIP-Seq_THP-1_Human0.98263624
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97789198
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96655340
90* GATA3_27048872_Chip-Seq_THYMUS_Human0.96204325
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96144106
92CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94110727
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94032061
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93841249
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93248365
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.92849413
97TFEB_21752829_ChIP-Seq_HELA_Human0.92695858
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92577710
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91650326
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90521149
101* SOX2_20726797_ChIP-Seq_SW620_Human0.90152512
102UTX_26944678_Chip-Seq_JUKART_Human0.89983674
103EZH2_27294783_Chip-Seq_NPCs_Mouse0.89519620
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89262455
105RUNX_20019798_ChIP-Seq_JUKART_Human0.88624012
106EGR1_19032775_ChIP-ChIP_M12_Human0.88382296
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87682381
108* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87409074
109FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87379577
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87182071
111FOXA1_25329375_ChIP-Seq_VCAP_Human0.86308224
112FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86308224
113* AR_20517297_ChIP-Seq_VCAP_Human0.84709847
114CRX_20693478_ChIP-Seq_RETINA_Mouse0.84480615
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83940434
116ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83354963
117SMRT_27268052_Chip-Seq_Bcells_Human0.83110823
118SALL4_22934838_ChIP-ChIP_CD34+_Human0.83006396
119SOX2_19829295_ChIP-Seq_ESCs_Human0.82814300
120NANOG_19829295_ChIP-Seq_ESCs_Human0.82814300
121VDR_24787735_ChIP-Seq_THP-1_Human0.82598672
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82415693
123GATA4_25053715_ChIP-Seq_YYC3_Human0.82410853
124VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82293874
125* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81442214
126BCL6_27268052_Chip-Seq_Bcells_Human0.81050287
127PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81028196
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80834907
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80425199
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80087844
131VDR_23849224_ChIP-Seq_CD4+_Human0.80058868
132ELK1_19687146_ChIP-ChIP_HELA_Human0.79721479
133GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79611247
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79403571
135DCP1A_22483619_ChIP-Seq_HELA_Human0.77470623
136FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.77464367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.76664234
2MP0009785_altered_susceptibility_to3.58916353
3MP0005360_urolithiasis3.38267421
4MP0001835_abnormal_antigen_presentation3.23788000
5MP0003724_increased_susceptibility_to3.04597792
6MP0002148_abnormal_hypersensitivity_rea2.81560252
7MP0002419_abnormal_innate_immunity2.76496880
8MP0009840_abnormal_foam_cell2.69013897
9MP0005025_abnormal_response_to2.56806402
10MP0003303_peritoneal_inflammation2.56299319
11MP0003191_abnormal_cellular_cholesterol2.46462610
12MP0006082_CNS_inflammation2.43966439
13MP0005000_abnormal_immune_tolerance2.43390005
14MP0005058_abnormal_lysosome_morphology2.42643631
15MP0002139_abnormal_hepatobiliary_system2.30208445
16MP0001533_abnormal_skeleton_physiology2.09603354
17MP0003195_calcinosis2.02707351
18MP0005671_abnormal_response_to2.02277077
19MP0003806_abnormal_nucleotide_metabolis1.98150354
20MP0002452_abnormal_antigen_presenting1.96536413
21MP0005464_abnormal_platelet_physiology1.95803269
22MP0003011_delayed_dark_adaptation1.89763868
23MP0000343_altered_response_to1.88099597
24MP0002723_abnormal_immune_serum1.87205630
25MP0009764_decreased_sensitivity_to1.86936982
26MP0001800_abnormal_humoral_immune1.84210842
27MP0001845_abnormal_inflammatory_respons1.82636285
28MP0001790_abnormal_immune_system1.80991431
29MP0005387_immune_system_phenotype1.80991431
30MP0008875_abnormal_xenobiotic_pharmacok1.80372484
31MP0008469_abnormal_protein_level1.79101586
32MP0003186_abnormal_redox_activity1.78022608
33MP0003183_abnormal_peptide_metabolism1.77262586
34MP0001819_abnormal_immune_cell1.76704440
35MP0005085_abnormal_gallbladder_physiolo1.75868891
36MP0002420_abnormal_adaptive_immunity1.74813751
37MP0000685_abnormal_immune_system1.69578436
38MP0001853_heart_inflammation1.68431288
39MP0004947_skin_inflammation1.68290057
40MP0010155_abnormal_intestine_physiology1.65778108
41MP0002405_respiratory_system_inflammati1.55176986
42MP0005365_abnormal_bile_salt1.52545192
43MP0003075_altered_response_to1.49818271
44MP0004782_abnormal_surfactant_physiolog1.48530165
45MP0000858_altered_metastatic_potential1.41598739
46MP0005166_decreased_susceptibility_to1.40351873
47MP0001666_abnormal_nutrient_absorption1.35496024
48MP0009333_abnormal_splenocyte_physiolog1.33560550
49MP0010329_abnormal_lipoprotein_level1.26876545
50MP0005319_abnormal_enzyme/_coenzyme1.26119339
51MP0001545_abnormal_hematopoietic_system1.25826505
52MP0005397_hematopoietic_system_phenotyp1.25826505
53MP0000716_abnormal_immune_system1.25087054
54MP0004510_myositis1.25005738
55MP0005451_abnormal_body_composition1.24974854
56MP0001873_stomach_inflammation1.24139290
57MP0001764_abnormal_homeostasis1.23986824
58MP0003448_altered_tumor_morphology1.23303171
59MP0003172_abnormal_lysosome_physiology1.23164266
60MP0003866_abnormal_defecation1.22677012
61MP0002876_abnormal_thyroid_physiology1.21859273
62MP0002166_altered_tumor_susceptibility1.20379359
63MP0009278_abnormal_bone_marrow1.20005081
64MP0003646_muscle_fatigue1.19788307
65MP0003763_abnormal_thymus_physiology1.18878955
66MP0003656_abnormal_erythrocyte_physiolo1.18489395
67MP0000604_amyloidosis1.18012145
68MP0005167_abnormal_blood-brain_barrier1.17464125
69MP0002132_abnormal_respiratory_system1.17296830
70MP0000609_abnormal_liver_physiology1.17018990
71MP0002837_dystrophic_cardiac_calcinosis1.12918966
72MP0009763_increased_sensitivity_to1.11461268
73MP0005164_abnormal_response_to1.11102841
74MP0002398_abnormal_bone_marrow1.10196900
75MP0002933_joint_inflammation1.08770603
76MP0000490_abnormal_crypts_of1.08302963
77MP0001663_abnormal_digestive_system1.07214103
78MP0002429_abnormal_blood_cell1.06307968
79MP0002277_abnormal_respiratory_mucosa1.06169668
80MP0000689_abnormal_spleen_morphology1.05994541
81MP0003279_aneurysm1.05430315
82MP0002006_tumorigenesis1.05104173
83MP0005332_abnormal_amino_acid1.04022768
84MP0004019_abnormal_vitamin_homeostasis1.02433314
85MP0006036_abnormal_mitochondrial_physio0.98554418
86MP0009643_abnormal_urine_homeostasis0.98056586
87MP0003300_gastrointestinal_ulcer0.97046845
88MP0005584_abnormal_enzyme/coenzyme_acti0.96589335
89MP0000465_gastrointestinal_hemorrhage0.96069323
90MP0002722_abnormal_immune_system0.95234570
91MP0005083_abnormal_biliary_tract0.94950696
92MP0003252_abnormal_bile_duct0.93202729
93MP0004147_increased_porphyrin_level0.92997285
94MP0001542_abnormal_bone_strength0.92590227
95MP0002332_abnormal_exercise_endurance0.91826101
96MP0002254_reproductive_system_inflammat0.90968306
97MP0005023_abnormal_wound_healing0.89846284
98MP0008260_abnormal_autophagy0.89497372
99MP0005310_abnormal_salivary_gland0.89040239
100MP0008004_abnormal_stomach_pH0.88893278
101MP0006054_spinal_hemorrhage0.88310459
102MP0003828_pulmonary_edema0.86556517
103MP0002998_abnormal_bone_remodeling0.85578706
104MP0010386_abnormal_urinary_bladder0.85194006
105MP0005390_skeleton_phenotype0.83983746
106MP0000249_abnormal_blood_vessel0.82669133
107MP0002138_abnormal_hepatobiliary_system0.80802878
108MP0001501_abnormal_sleep_pattern0.79966878
109MP0002118_abnormal_lipid_homeostasis0.79919299
110MP0005084_abnormal_gallbladder_morpholo0.79330654
111MP0009697_abnormal_copulation0.79321970
112MP0004883_abnormal_blood_vessel0.78795067
113MP0001851_eye_inflammation0.78631513
114MP0008438_abnormal_cutaneous_collagen0.78495044
115MP0005376_homeostasis/metabolism_phenot0.77737547
116MP0005636_abnormal_mineral_homeostasis0.77138350
117MP0002136_abnormal_kidney_physiology0.76361940

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.06216053
2Eczematoid dermatitis (HP:0000976)5.55840750
3Recurrent bacterial skin infections (HP:0005406)5.53031615
4Recurrent gram-negative bacterial infections (HP:0005420)5.25945374
5Abnormality of macrophages (HP:0004311)4.19736865
6Vacuolated lymphocytes (HP:0001922)3.98539059
7Myositis (HP:0100614)3.79727205
8Autoimmune thrombocytopenia (HP:0001973)3.51542969
9Elevated erythrocyte sedimentation rate (HP:0003565)3.43011178
10Mediastinal lymphadenopathy (HP:0100721)3.32334597
11Chronic obstructive pulmonary disease (HP:0006510)3.30138772
12Obstructive lung disease (HP:0006536)3.30138772
13Gingivitis (HP:0000230)3.23016571
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.22806333
15Abnormality of T cell number (HP:0011839)3.16236455
16Recurrent skin infections (HP:0001581)3.15115142
17Orchitis (HP:0100796)3.13681918
18Systemic lupus erythematosus (HP:0002725)3.11645793
19Stomatitis (HP:0010280)3.06900407
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.03728550
21Abnormality of B cell number (HP:0010975)2.99704267
22Increased cerebral lipofuscin (HP:0011813)2.94667168
23Urticaria (HP:0001025)2.86160262
24Pustule (HP:0200039)2.79710973
25Gastrointestinal infarctions (HP:0005244)2.71808063
26Interstitial pulmonary disease (HP:0006530)2.71553052
27Nausea (HP:0002018)2.67367758
28T lymphocytopenia (HP:0005403)2.66777613
29Abnormality of T cells (HP:0002843)2.61859780
30Recurrent fungal infections (HP:0002841)2.61842820
31Retrobulbar optic neuritis (HP:0100654)2.61406710
32Optic neuritis (HP:0100653)2.61406710
33Neoplasm of head and neck (HP:0012288)2.61132335
34Esophageal neoplasm (HP:0100751)2.61132335
35Keratoconjunctivitis (HP:0001096)2.57966050
36Eosinophilia (HP:0001880)2.57668680
37Hemoptysis (HP:0002105)2.56311872
38Recurrent cutaneous fungal infections (HP:0011370)2.55582693
39Chronic mucocutaneous candidiasis (HP:0002728)2.55582693
40IgG deficiency (HP:0004315)2.52459383
41Hypobetalipoproteinemia (HP:0003563)2.49841369
42Periodontitis (HP:0000704)2.49489452
43Joint hemorrhage (HP:0005261)2.47406795
44B lymphocytopenia (HP:0010976)2.47104770
45Chronic diarrhea (HP:0002028)2.44510531
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.42848358
47Xanthomatosis (HP:0000991)2.35086635
48Axonal loss (HP:0003447)2.34517790
49Vasculitis (HP:0002633)2.32811910
50Generalized aminoaciduria (HP:0002909)2.32010939
51Abnormality of glutamine family amino acid metabolism (HP:0010902)2.31222410
52Petechiae (HP:0000967)2.26642279
53Granulocytopenia (HP:0001913)2.25948850
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.22942363
55Meningitis (HP:0001287)2.22288501
56Gingival bleeding (HP:0000225)2.21158653
57Dysostosis multiplex (HP:0000943)2.20101768
58Hypoglycemic coma (HP:0001325)2.17072093
59Recurrent viral infections (HP:0004429)2.16754004
60Hepatic necrosis (HP:0002605)2.16197007
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15110490
62Urinary glycosaminoglycan excretion (HP:0003541)2.13075895
63Mucopolysacchariduria (HP:0008155)2.13075895
64Tetraparesis (HP:0002273)2.12993364
65Abnormality of the common coagulation pathway (HP:0010990)2.11984012
66Gangrene (HP:0100758)2.11211412
67Reduced antithrombin III activity (HP:0001976)2.10555317
68Recurrent bronchitis (HP:0002837)2.09593836
69Parakeratosis (HP:0001036)2.08264452
70Prolonged partial thromboplastin time (HP:0003645)2.07708754
71Increased serum ferritin (HP:0003281)2.07100423
72Glomerulonephritis (HP:0000099)2.06981995
73Abnormality of iron homeostasis (HP:0011031)2.04747794
74Abnormality of eosinophils (HP:0001879)2.04280585
75Abnormality of fatty-acid metabolism (HP:0004359)2.03629483
76Anorexia (HP:0002039)2.02571354
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.02540698
78Hepatosplenomegaly (HP:0001433)2.01982183
79Abnormality of the pleura (HP:0002103)2.01528495
80Panhypogammaglobulinemia (HP:0003139)2.00923397
81Pulmonary infiltrates (HP:0002113)1.99976473
82Malnutrition (HP:0004395)1.99848238
83Increased IgM level (HP:0003496)1.99671706
84Thrombocytosis (HP:0001894)1.99607996
85Abnormality of the prostate (HP:0008775)1.99241377
86Hypergammaglobulinemia (HP:0010702)1.98819928
87Basal ganglia calcification (HP:0002135)1.98283221
88Abnormality of urine glucose concentration (HP:0011016)1.97635692
89Glycosuria (HP:0003076)1.97635692
90Thyroiditis (HP:0100646)1.97307797
91Keratoconjunctivitis sicca (HP:0001097)1.96754203
92Mutism (HP:0002300)1.96223653
93Purpura (HP:0000979)1.93761630
94Skin rash (HP:0000988)1.93287333
95Abnormality of glycolipid metabolism (HP:0010969)1.93007903
96Abnormality of liposaccharide metabolism (HP:0010968)1.93007903
97Abnormality of glycosphingolipid metabolism (HP:0004343)1.93007903
98Abnormality of polysaccharide metabolism (HP:0011012)1.93007901
99Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93007901
100Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93007901
101Cellulitis (HP:0100658)1.92572020
102Abnormality of purine metabolism (HP:0004352)1.91430132
103Spontaneous hematomas (HP:0007420)1.89983654
104Agammaglobulinemia (HP:0004432)1.89715497
105Pulmonary embolism (HP:0002204)1.89679934
106Encephalitis (HP:0002383)1.88834779
107Glomerulopathy (HP:0100820)1.88713765
108Prostate neoplasm (HP:0100787)1.88040623
109Abnormality of transition element cation homeostasis (HP:0011030)1.87711375
110Hepatocellular necrosis (HP:0001404)1.87285647
111Leukocytosis (HP:0001974)1.87121314
112Increased IgE level (HP:0003212)1.86612599
113Arterial thrombosis (HP:0004420)1.86392877
114Epistaxis (HP:0000421)1.86078934
115Loss of speech (HP:0002371)1.85985473
116Abnormality of nucleobase metabolism (HP:0010932)1.85257062
117Joint swelling (HP:0001386)1.84999192
118Episodic fever (HP:0001954)1.84934293
119Complement deficiency (HP:0004431)1.84213640
120Recurrent pneumonia (HP:0006532)1.84121088
1213-Methylglutaconic aciduria (HP:0003535)1.83920367
122Hypoproteinemia (HP:0003075)1.83762955
123Chronic otitis media (HP:0000389)1.83520320
124IgM deficiency (HP:0002850)1.83130228
125Abnormality of T cell physiology (HP:0011840)1.82850898
126Autoimmune hemolytic anemia (HP:0001890)1.81606923
127Poor head control (HP:0002421)1.81324782
128Thick nail (HP:0001805)1.81318632
129Amyloidosis (HP:0011034)1.81266864
130Mitochondrial inheritance (HP:0001427)1.81241101
131Chest pain (HP:0100749)1.80243004
132Lipid accumulation in hepatocytes (HP:0006561)1.79951268
133Peritonitis (HP:0002586)1.79841125
134Polyneuropathy (HP:0001271)1.79713177
135Hypochromic anemia (HP:0001931)1.79408129
136Exertional dyspnea (HP:0002875)1.78962591
137Conjunctival hamartoma (HP:0100780)1.78925815
138Conjugated hyperbilirubinemia (HP:0002908)1.77288570
139Abnormal platelet function (HP:0011869)1.77284386
140Impaired platelet aggregation (HP:0003540)1.77284386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.29104684
2MAP3K123.26072636
3ERN12.94383590
4RIPK42.85495042
5TBK12.72335477
6IRAK42.71168137
7MAP3K142.52124895
8TYK22.42142103
9TAOK32.37502727
10MAP4K12.33256697
11KIT2.32321150
12PIM22.28229256
13IRAK32.16994863
14TXK2.06522883
15NME22.02247395
16IKBKE1.90407297
17TEC1.89303905
18ZAP701.82301715
19ADRBK21.82008588
20JAK31.79283673
21MAP4K21.72826900
22PBK1.72445506
23TLK11.63511115
24MST41.63105399
25CSK1.57288002
26MAP3K111.52613058
27BTK1.51955452
28ARAF1.48756734
29NEK91.47952105
30GRK61.44502433
31IKBKB1.38620564
32FRK1.38484890
33DDR21.35744047
34SYK1.34811951
35EPHB11.33569532
36MAP2K31.31753631
37MYLK1.31555762
38STK161.30068405
39EIF2AK11.30052843
40BCKDK1.28723242
41MAP3K31.26801939
42JAK11.25227700
43ABL21.22506440
44NEK11.21828105
45STK101.21288876
46TESK11.19558144
47BMPR21.15253276
48PRKG21.14282656
49GRK11.07277451
50FGFR41.05700698
51LYN1.03487930
52STK241.02996506
53MST1R1.01695637
54BMPR1B0.98724768
55MOS0.97561829
56MAP3K50.97511067
57TESK20.97478414
58FLT30.95398359
59FES0.93893811
60MATK0.93133494
61HCK0.92249451
62PIK3CA0.91785794
63MUSK0.90430026
64ITK0.89494469
65PDK20.89205792
66PIK3CG0.86745998
67EIF2AK30.86262049
68PAK40.85797085
69GRK70.85418810
70LCK0.84504521
71PRKCQ0.84217793
72CSF1R0.83563410
73PRKCD0.83504653
74MAP3K130.82695394
75KDR0.81863813
76PIM10.80350819
77ADRBK10.79872922
78PTK2B0.78209857
79LIMK10.78181237
80FGR0.76825632
81JAK20.76516333
82TRPM70.76266459
83TNK20.75580502
84LRRK20.75352293
85RPS6KA40.72804163
86MAP3K10.72177053
87GRK50.70124695
88PDK10.68430587
89OXSR10.68281211
90NME10.66568286
91MAP2K20.66552597
92BRAF0.63706005
93MAP3K60.63149090
94CHUK0.62871080
95CDK190.60238600
96ERBB40.59101336
97CDK80.57011780
98TAOK20.56289369
99MAPK110.55598961
100BRSK20.54913197
101MAPK40.54663625
102MAPK120.54507457
103FGFR30.53810802
104NUAK10.52577860
105KSR20.50657718
106EGFR0.49199541
107ZAK0.48674883
108EIF2AK20.48543810
109IGF1R0.48128675
110CAMKK20.46876490
111TGFBR20.45407183
112DAPK20.45310884
113INSRR0.43205168
114ABL10.43201094
115MAPKAPK30.42353779
116MAP2K60.41342807
117FYN0.40967748
118EPHA30.39735619
119TAOK10.39275398
120MAPKAPK20.38257696
121PDPK10.37949772
122RAF10.37816027
123DAPK10.37408136
124MARK30.37359724
125SIK30.36002709
126NLK0.35519300
127ACVR1B0.35080859
128IRAK10.34847727
129SCYL20.34303437
130MAPK70.34223425
131MAP3K80.33809648

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.23372335
2Autoimmune thyroid disease_Homo sapiens_hsa053203.22539770
3Leishmaniasis_Homo sapiens_hsa051402.63087295
4Legionellosis_Homo sapiens_hsa051342.39756154
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.35346169
6Graft-versus-host disease_Homo sapiens_hsa053322.09920826
7Caffeine metabolism_Homo sapiens_hsa002322.09695479
8Proteasome_Homo sapiens_hsa030502.01429350
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96099204
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.86924073
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82422893
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78855442
13Pertussis_Homo sapiens_hsa051331.72101375
14Folate biosynthesis_Homo sapiens_hsa007901.63317248
15Viral myocarditis_Homo sapiens_hsa054161.62689555
16Other glycan degradation_Homo sapiens_hsa005111.62270423
17Lysosome_Homo sapiens_hsa041421.60662121
18Tuberculosis_Homo sapiens_hsa051521.59089951
19Rheumatoid arthritis_Homo sapiens_hsa053231.56599373
20Histidine metabolism_Homo sapiens_hsa003401.52876714
21Pentose phosphate pathway_Homo sapiens_hsa000301.52397035
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48994585
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47252910
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45328863
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44714418
26Galactose metabolism_Homo sapiens_hsa000521.41748546
27Phagosome_Homo sapiens_hsa041451.41563837
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39065522
29Malaria_Homo sapiens_hsa051441.37414061
30Starch and sucrose metabolism_Homo sapiens_hsa005001.37057552
31Complement and coagulation cascades_Homo sapiens_hsa046101.35850605
32Osteoclast differentiation_Homo sapiens_hsa043801.34722466
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34487755
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.31590499
35Oxidative phosphorylation_Homo sapiens_hsa001901.31390555
36Protein export_Homo sapiens_hsa030601.31120307
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.30045055
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.25735586
39Salmonella infection_Homo sapiens_hsa051321.24326344
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24237998
41Peroxisome_Homo sapiens_hsa041461.23452502
42Fructose and mannose metabolism_Homo sapiens_hsa000511.22848355
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.20167974
44Fat digestion and absorption_Homo sapiens_hsa049751.20148886
45Sulfur metabolism_Homo sapiens_hsa009201.19365590
46Arginine biosynthesis_Homo sapiens_hsa002201.17561623
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16107727
48Asthma_Homo sapiens_hsa053101.14369670
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13530215
50Hematopoietic cell lineage_Homo sapiens_hsa046401.12654400
51Allograft rejection_Homo sapiens_hsa053301.11764252
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10634122
53Measles_Homo sapiens_hsa051621.09991077
54Influenza A_Homo sapiens_hsa051641.05667778
55Renin-angiotensin system_Homo sapiens_hsa046141.05264098
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.03144335
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.02718514
58Antigen processing and presentation_Homo sapiens_hsa046121.00436266
59Type I diabetes mellitus_Homo sapiens_hsa049401.00203409
60Parkinsons disease_Homo sapiens_hsa050120.98032033
61Arachidonic acid metabolism_Homo sapiens_hsa005900.97382006
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96968465
63Shigellosis_Homo sapiens_hsa051310.96633278
64Mineral absorption_Homo sapiens_hsa049780.95828047
65TNF signaling pathway_Homo sapiens_hsa046680.95133449
66Fatty acid degradation_Homo sapiens_hsa000710.94557999
67Carbon metabolism_Homo sapiens_hsa012000.93646830
68Linoleic acid metabolism_Homo sapiens_hsa005910.91497497
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91390788
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89961628
71Herpes simplex infection_Homo sapiens_hsa051680.89375680
72Glutathione metabolism_Homo sapiens_hsa004800.85749254
73Tryptophan metabolism_Homo sapiens_hsa003800.85526169
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82113418
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79063966
76Regulation of autophagy_Homo sapiens_hsa041400.76528619
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75514799
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74605741
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74467012
80Alzheimers disease_Homo sapiens_hsa050100.74091917
81Vitamin digestion and absorption_Homo sapiens_hsa049770.72872160
82African trypanosomiasis_Homo sapiens_hsa051430.72714804
83Nitrogen metabolism_Homo sapiens_hsa009100.72380465
84PPAR signaling pathway_Homo sapiens_hsa033200.71597909
85Apoptosis_Homo sapiens_hsa042100.71496972
86Collecting duct acid secretion_Homo sapiens_hsa049660.70825988
87beta-Alanine metabolism_Homo sapiens_hsa004100.70220572
88Toxoplasmosis_Homo sapiens_hsa051450.69306848
89Chemical carcinogenesis_Homo sapiens_hsa052040.67782237
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66627706
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.66548294
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62217043
93Hepatitis C_Homo sapiens_hsa051600.61592172
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61317295
95Systemic lupus erythematosus_Homo sapiens_hsa053220.60811088
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59695368
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59564860
98T cell receptor signaling pathway_Homo sapiens_hsa046600.58535592
99Phenylalanine metabolism_Homo sapiens_hsa003600.56684352
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.54943345
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54535815
102Hepatitis B_Homo sapiens_hsa051610.53302310
103Pyruvate metabolism_Homo sapiens_hsa006200.52977982
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52186488
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.51912721
106Chemokine signaling pathway_Homo sapiens_hsa040620.48065045
107Primary immunodeficiency_Homo sapiens_hsa053400.47919379
108B cell receptor signaling pathway_Homo sapiens_hsa046620.47542326
109Retinol metabolism_Homo sapiens_hsa008300.47324590
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45514212
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44477530
112Ether lipid metabolism_Homo sapiens_hsa005650.43938678
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43567633
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43479729
115Glycerolipid metabolism_Homo sapiens_hsa005610.41514445
116Huntingtons disease_Homo sapiens_hsa050160.30789747
117Platelet activation_Homo sapiens_hsa046110.28469637
118Epstein-Barr virus infection_Homo sapiens_hsa051690.26392417

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