GLRX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.92888709
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.58804590
3cell wall macromolecule catabolic process (GO:0016998)5.48534633
4cell wall macromolecule metabolic process (GO:0044036)5.48534633
5chaperone-mediated protein transport (GO:0072321)5.02127339
6ATP synthesis coupled proton transport (GO:0015986)4.90138814
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.90138814
8ribosomal small subunit biogenesis (GO:0042274)4.66935326
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.59213881
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.58963405
11regulation of mitochondrial translation (GO:0070129)4.53185832
12respiratory electron transport chain (GO:0022904)4.44378256
13maturation of SSU-rRNA (GO:0030490)4.40622270
14electron transport chain (GO:0022900)4.29423895
15ribosomal large subunit biogenesis (GO:0042273)4.26240410
16presynaptic membrane assembly (GO:0097105)4.25033683
17protein targeting to mitochondrion (GO:0006626)4.24651680
18rRNA modification (GO:0000154)4.24608513
19motile cilium assembly (GO:0044458)4.24099838
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.22866933
21nucleobase-containing small molecule interconversion (GO:0015949)4.21457712
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.18319727
23epithelial cilium movement (GO:0003351)4.17483181
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.00224949
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.99357919
26negative regulation of ligase activity (GO:0051352)3.96278370
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.96278370
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.95867101
29ribonucleoprotein complex biogenesis (GO:0022613)3.93624269
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.87802320
31protein localization to mitochondrion (GO:0070585)3.87738509
32presynaptic membrane organization (GO:0097090)3.85920474
33ribosome assembly (GO:0042255)3.84534008
34translation (GO:0006412)3.81031133
35establishment of protein localization to mitochondrion (GO:0072655)3.81021748
36oxidative phosphorylation (GO:0006119)3.78573084
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.78058156
38regulation of cellular amino acid metabolic process (GO:0006521)3.76437735
39protein localization to synapse (GO:0035418)3.74804076
40multicellular organism reproduction (GO:0032504)3.73694407
41viral transcription (GO:0019083)3.73439740
42cilium or flagellum-dependent cell motility (GO:0001539)3.73422589
43cotranslational protein targeting to membrane (GO:0006613)3.72694797
44protein targeting to ER (GO:0045047)3.70124349
45ribosome biogenesis (GO:0042254)3.66285338
46startle response (GO:0001964)3.65634362
47CENP-A containing nucleosome assembly (GO:0034080)3.63935051
48postsynaptic membrane organization (GO:0001941)3.63832412
49translational termination (GO:0006415)3.63519697
50cellular component biogenesis (GO:0044085)3.62983607
51mitochondrial respiratory chain complex assembly (GO:0033108)3.60485703
522-deoxyribonucleotide biosynthetic process (GO:0009265)3.59754984
53deoxyribose phosphate biosynthetic process (GO:0046385)3.59754984
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.59037419
55protein localization to endoplasmic reticulum (GO:0070972)3.59007987
56rRNA methylation (GO:0031167)3.58282196
57neuron cell-cell adhesion (GO:0007158)3.57391478
58protein complex biogenesis (GO:0070271)3.57389866
59pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.57012849
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56776641
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.56770285
62positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.56543263
63acrosome reaction (GO:0007340)3.56024707
64fusion of sperm to egg plasma membrane (GO:0007342)3.55269507
65protein maturation by protein folding (GO:0022417)3.53474906
66axonemal dynein complex assembly (GO:0070286)3.53010416
67deoxyribonucleotide biosynthetic process (GO:0009263)3.52853872
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.52852845
69cilium movement (GO:0003341)3.49704688
70mitochondrial respiratory chain complex I assembly (GO:0032981)3.48882615
71NADH dehydrogenase complex assembly (GO:0010257)3.48882615
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48882615
73ionotropic glutamate receptor signaling pathway (GO:0035235)3.47955025
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.47558048
75rRNA processing (GO:0006364)3.47155417
76regulation of short-term neuronal synaptic plasticity (GO:0048172)3.46971437
77chromatin remodeling at centromere (GO:0031055)3.46876053
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.46420599
79cullin deneddylation (GO:0010388)3.45717126
80positive regulation of ligase activity (GO:0051351)3.45108309
81formation of translation preinitiation complex (GO:0001731)3.45010203
82termination of RNA polymerase III transcription (GO:0006386)3.43943106
83transcription elongation from RNA polymerase III promoter (GO:0006385)3.43943106
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.43005092
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.43005092
86protein deneddylation (GO:0000338)3.40963472
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.40417601
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.40417601
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.40417601
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.39403965
91G-protein coupled receptor internalization (GO:0002031)3.39045189
92regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.37065694
93glutamate receptor signaling pathway (GO:0007215)3.36217889
94signal transduction involved in DNA integrity checkpoint (GO:0072401)3.34295280
95signal transduction involved in DNA damage checkpoint (GO:0072422)3.34295280
96vocalization behavior (GO:0071625)3.33402956
97pseudouridine synthesis (GO:0001522)3.31494491
98translational initiation (GO:0006413)3.30566630
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29950655
100rRNA metabolic process (GO:0016072)3.29068227
101mitotic metaphase plate congression (GO:0007080)3.28508997
102telomere maintenance via semi-conservative replication (GO:0032201)3.28168631
103regulation of ubiquitin-protein transferase activity (GO:0051438)3.27335647
104protein neddylation (GO:0045116)3.26630573
105mitochondrial transport (GO:0006839)3.25852006
106ribosomal small subunit assembly (GO:0000028)3.25836303
107translational elongation (GO:0006414)3.25724413
108signal transduction involved in cell cycle checkpoint (GO:0072395)3.24659499
109pyrimidine nucleotide catabolic process (GO:0006244)3.22081552
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21725951
111auditory receptor cell stereocilium organization (GO:0060088)3.20526954
112spliceosomal snRNP assembly (GO:0000387)3.20125640
113DNA replication checkpoint (GO:0000076)3.18943538
114regulation of ligase activity (GO:0051340)3.18792969
115kinetochore organization (GO:0051383)3.18400014
116synaptic transmission, glutamatergic (GO:0035249)3.16994974
117regulation of respiratory system process (GO:0044065)3.16355638
118tricarboxylic acid cycle (GO:0006099)3.15399826
119maturation of 5.8S rRNA (GO:0000460)3.13932928
120purine nucleobase biosynthetic process (GO:0009113)3.13348208
121righting reflex (GO:0060013)3.09975637
122DNA strand elongation involved in DNA replication (GO:0006271)3.09779932
123deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.09295031
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09258608
125DNA strand elongation (GO:0022616)3.05794466
126kinetochore assembly (GO:0051382)3.05772597
127cerebral cortex radially oriented cell migration (GO:0021799)3.05236400
128nonmotile primary cilium assembly (GO:0035058)3.04698319
129establishment of integrated proviral latency (GO:0075713)3.04517794
130superoxide anion generation (GO:0042554)3.00240986
131neuronal action potential propagation (GO:0019227)2.99729185
132transcription from mitochondrial promoter (GO:0006390)2.98855157
133regulation of glutamate receptor signaling pathway (GO:1900449)2.98668702
134retinal cone cell development (GO:0046549)2.97952556
135neuron-neuron synaptic transmission (GO:0007270)2.97009490
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96742711
137neurotransmitter-gated ion channel clustering (GO:0072578)2.95922365
138plasma membrane fusion (GO:0045026)2.95696116
139pteridine-containing compound biosynthetic process (GO:0042559)2.94856634
140inner ear receptor stereocilium organization (GO:0060122)2.94126046
141sperm motility (GO:0030317)2.93812424
142viral life cycle (GO:0019058)2.93752730
143positive regulation of action potential (GO:0045760)2.93283288
144centriole assembly (GO:0098534)2.91863224
145nucleoside salvage (GO:0043174)2.91855579
146serotonin receptor signaling pathway (GO:0007210)2.87975031
147synaptic vesicle endocytosis (GO:0048488)2.87495146
148single strand break repair (GO:0000012)2.86268345
149regulation of respiratory gaseous exchange (GO:0043576)2.86238390
150regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78085250
151regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77668005
152photoreceptor cell maintenance (GO:0045494)2.77548304
153gamma-aminobutyric acid signaling pathway (GO:0007214)2.76245877
154calcium ion-dependent exocytosis (GO:0017156)2.75555228
155regulation of rhodopsin mediated signaling pathway (GO:0022400)2.73007526
156daunorubicin metabolic process (GO:0044597)2.70774154
157polyketide metabolic process (GO:0030638)2.70774154
158doxorubicin metabolic process (GO:0044598)2.70774154
159transmission of nerve impulse (GO:0019226)2.70468918
160reproduction (GO:0000003)2.70179469
161regulation of postsynaptic membrane potential (GO:0060078)2.69099240
162DNA integration (GO:0015074)2.67805565
163calcium ion import (GO:0070509)2.66505189
164sulfate transmembrane transport (GO:1902358)2.64324634
165microtubule depolymerization (GO:0007019)2.62994496
166synaptic vesicle exocytosis (GO:0016079)2.62173148
167L-amino acid import (GO:0043092)2.61540437
168acrosome assembly (GO:0001675)2.61457334
169negative regulation of heart rate (GO:0010459)2.60648705
170reflex (GO:0060004)2.60632681
171urinary tract smooth muscle contraction (GO:0014848)2.58915528
172protein localization to cilium (GO:0061512)2.58909046
173rhodopsin mediated signaling pathway (GO:0016056)2.58814160
174positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58131837
175positive regulation of neurotransmitter secretion (GO:0001956)2.55874277
176regulation of timing of cell differentiation (GO:0048505)2.55324683
177detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54448264
178preassembly of GPI anchor in ER membrane (GO:0016254)2.53208124
179protein K11-linked deubiquitination (GO:0035871)2.53133585
180regulation of synaptic transmission, glutamatergic (GO:0051966)2.50545425
181retina layer formation (GO:0010842)2.49713589
182keratinocyte development (GO:0003334)2.49323877
183protein heterotetramerization (GO:0051290)2.49127797
184opioid receptor signaling pathway (GO:0038003)2.46650979
185membrane depolarization during action potential (GO:0086010)2.44778523
186detection of light stimulus involved in visual perception (GO:0050908)2.44275767
187detection of light stimulus involved in sensory perception (GO:0050962)2.44275767
188regulation of cilium movement (GO:0003352)2.44015643
189regulation of neurotransmitter secretion (GO:0046928)2.43453068
190neuronal ion channel clustering (GO:0045161)2.43049300
191regulation of synapse maturation (GO:0090128)2.42863636
192female gonad development (GO:0008585)2.42858277
193membrane hyperpolarization (GO:0060081)2.41939270
194regulation of synaptic transmission, GABAergic (GO:0032228)2.41309422
195cilium assembly (GO:0042384)2.41069351
196membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.41029339
197regulation of MHC class I biosynthetic process (GO:0045343)2.40898771
198sulfate transport (GO:0008272)2.40511107
199membrane depolarization (GO:0051899)2.40387726
200eye photoreceptor cell development (GO:0042462)2.37698484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.91488803
2E2F7_22180533_ChIP-Seq_HELA_Human4.58513564
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.27883313
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.22392706
5GBX2_23144817_ChIP-Seq_PC3_Human3.98187695
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86528568
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86082443
8EZH2_22144423_ChIP-Seq_EOC_Human3.84258303
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.66563954
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.47394675
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.41042121
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.32996908
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10959737
14ZFP57_27257070_Chip-Seq_ESCs_Mouse3.03558192
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98754070
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81747030
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.77761750
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73043051
19DCP1A_22483619_ChIP-Seq_HELA_Human2.72474404
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.60366902
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60236736
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55690524
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53847032
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52850852
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.50650263
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.43403118
27ELK1_19687146_ChIP-ChIP_HELA_Human2.43210551
28VDR_23849224_ChIP-Seq_CD4+_Human2.40243619
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39508802
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35590529
31CBX2_27304074_Chip-Seq_ESCs_Mouse2.35500903
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35198189
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32349014
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28805014
35XRN2_22483619_ChIP-Seq_HELA_Human2.25183188
36SRF_21415370_ChIP-Seq_HL-1_Mouse2.21736033
37* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.21250327
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19116683
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19035348
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18823082
41FOXP3_21729870_ChIP-Seq_TREG_Human2.18024620
42GABP_19822575_ChIP-Seq_HepG2_Human2.16780020
43BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15109986
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10547822
45PCGF2_27294783_Chip-Seq_NPCs_Mouse2.09587522
46NFE2_27457419_Chip-Seq_LIVER_Mouse2.07835198
47FOXM1_23109430_ChIP-Seq_U2OS_Human2.06664323
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03414678
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02671743
50JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01256496
51TTF2_22483619_ChIP-Seq_HELA_Human2.01209276
52* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.00786818
53* NANOG_18555785_Chip-Seq_ESCs_Mouse1.99034199
54VDR_22108803_ChIP-Seq_LS180_Human1.96133012
55* AR_21909140_ChIP-Seq_LNCAP_Human1.95017434
56* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.94459034
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92720546
58* E2F1_18555785_Chip-Seq_ESCs_Mouse1.90274967
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89726539
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.87835689
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86985967
62* P53_22387025_ChIP-Seq_ESCs_Mouse1.86103053
63REST_21632747_ChIP-Seq_MESCs_Mouse1.85798203
64P300_19829295_ChIP-Seq_ESCs_Human1.82997399
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82362055
66ZNF263_19887448_ChIP-Seq_K562_Human1.82056270
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81569055
68* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.81043440
69* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80050338
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.79753788
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78685660
72* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78342491
73* CMYC_18555785_Chip-Seq_ESCs_Mouse1.78146831
74* STAT3_18555785_Chip-Seq_ESCs_Mouse1.77641639
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77304913
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73106370
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72526236
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72442546
79TAF15_26573619_Chip-Seq_HEK293_Human1.72163612
80* P300_18555785_Chip-Seq_ESCs_Mouse1.71916362
81* EZH2_27294783_Chip-Seq_NPCs_Mouse1.71862828
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71760416
83* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.69494135
84* NMYC_18555785_Chip-Seq_ESCs_Mouse1.69206718
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65619676
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65303350
87RNF2_27304074_Chip-Seq_NSC_Mouse1.65057418
88* SOX2_18555785_Chip-Seq_ESCs_Mouse1.64331546
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62960158
90TFEB_21752829_ChIP-Seq_HELA_Human1.62830788
91* OCT4_18555785_Chip-Seq_ESCs_Mouse1.62453838
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61907440
93SMAD4_21799915_ChIP-Seq_A2780_Human1.61804766
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61606302
95* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.58926676
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58602091
97FUS_26573619_Chip-Seq_HEK293_Human1.57991961
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56416140
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56096672
100* KLF4_18555785_Chip-Seq_ESCs_Mouse1.54555356
101AR_21572438_ChIP-Seq_LNCaP_Human1.54395901
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51061127
103* E2F1_21310950_ChIP-Seq_MCF-7_Human1.49652117
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49049466
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48602581
106* PU1_27457419_Chip-Seq_LIVER_Mouse1.47121143
107* CTCF_18555785_Chip-Seq_ESCs_Mouse1.46760390
108EZH2_27294783_Chip-Seq_ESCs_Mouse1.46222417
109RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46157742
110EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46157742
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45682581
112* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.45603827
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.45572918
114* ZFX_18555785_Chip-Seq_ESCs_Mouse1.44895658
115* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44701282
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44498579
117IGF1R_20145208_ChIP-Seq_DFB_Human1.44100936
118SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43463979
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.43133840
120* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40683538
121SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40305075
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39631590
123MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39179430
124DROSHA_22980978_ChIP-Seq_HELA_Human1.38991341
125* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.38801370
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38617255
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38204441
128* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36831370
129PIAS1_25552417_ChIP-Seq_VCAP_Human1.34910643
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34231445
131* KDM2B_26808549_Chip-Seq_REH_Human1.34172242
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32549128
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.31029484
134YY1_21170310_ChIP-Seq_MESCs_Mouse1.30850867
135STAT3_23295773_ChIP-Seq_U87_Human1.30216757
136* CRX_20693478_ChIP-Seq_RETINA_Mouse1.30058812
137MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30007893
138ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29844445
139KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29764246
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28513364
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28316770
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28316770
143* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27671557
144BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27225328
145TCF4_23295773_ChIP-Seq_U87_Human1.27222153
146ER_23166858_ChIP-Seq_MCF-7_Human1.27150360
147KDM5A_27292631_Chip-Seq_BREAST_Human1.26253278
148TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25543266
149NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25502517
150* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25182390
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24288061
152AR_25329375_ChIP-Seq_VCAP_Human1.24224900
153* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23581338
154* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23288350
155* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22808774
156* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21736353
157ELK1_22589737_ChIP-Seq_MCF10A_Human1.21348682
158CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20845653
159EWS_26573619_Chip-Seq_HEK293_Human1.20359151
160CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20139548
161CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17652362
162CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.16318083
163MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14855098
164PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14232670
165PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14046339
166POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14010822
167RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13365970
168SMAD_19615063_ChIP-ChIP_OVARY_Human1.13084884
169CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12752540
170KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12135800
171RUNX2_22187159_ChIP-Seq_PCA_Human1.11817004
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10697142
173* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10130849
174* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10068067
175SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08687138
176MYC_18940864_ChIP-ChIP_HL60_Human1.07875568
177HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05971836
178GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03382479
179PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01473621
180* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97695705
181STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96563667
182SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94352798
183ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94170295
184SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92798414
185PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90512553
186SOX17_20123909_ChIP-Seq_XEN_Mouse0.90445862
187* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89834463
188ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.88867212
189TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88638428
190ELF5_23300383_ChIP-Seq_T47D_Human0.86597838
191* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85463053
192SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82317292
193CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80263884
194KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.79756696
195FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78060589
196DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75964698
197SPI1_23547873_ChIP-Seq_NB4_Human0.71406996
198SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71337379
199CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.70859343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.97307708
2MP0003880_abnormal_central_pattern4.00142739
3MP0006036_abnormal_mitochondrial_physio3.69211686
4MP0004957_abnormal_blastocyst_morpholog3.57914066
5MP0003186_abnormal_redox_activity3.47141105
6MP0010094_abnormal_chromosome_stability3.46310329
7MP0001188_hyperpigmentation3.44952004
8MP0003693_abnormal_embryo_hatching3.36567908
9MP0003111_abnormal_nucleus_morphology3.12553139
10MP0003077_abnormal_cell_cycle3.09228830
11MP0004859_abnormal_synaptic_plasticity3.01488313
12MP0006292_abnormal_olfactory_placode2.77497136
13MP0009046_muscle_twitch2.77316461
14MP0001486_abnormal_startle_reflex2.60804253
15MP0003136_yellow_coat_color2.57683631
16MP0008932_abnormal_embryonic_tissue2.57331581
17MP0006035_abnormal_mitochondrial_morpho2.46624398
18MP0005171_absent_coat_pigmentation2.45109617
19MP0002877_abnormal_melanocyte_morpholog2.41946940
20MP0005423_abnormal_somatic_nervous2.39322602
21MP0008007_abnormal_cellular_replicative2.38521276
22MP0003786_premature_aging2.37137292
23MP0005408_hypopigmentation2.35250784
24MP0001986_abnormal_taste_sensitivity2.35214833
25MP0000372_irregular_coat_pigmentation2.34972432
26MP0009745_abnormal_behavioral_response2.34301062
27MP0005410_abnormal_fertilization2.31871245
28MP0001968_abnormal_touch/_nociception2.29088000
29MP0005646_abnormal_pituitary_gland2.28957156
30MP0005645_abnormal_hypothalamus_physiol2.24561355
31MP0003635_abnormal_synaptic_transmissio2.22169099
32MP0000566_synostosis2.21632661
33MP0002102_abnormal_ear_morphology2.14654727
34MP0005551_abnormal_eye_electrophysiolog2.12927280
35MP0002572_abnormal_emotion/affect_behav2.11807395
36MP0005451_abnormal_body_composition2.10333095
37MP0004142_abnormal_muscle_tone2.03399929
38MP0001984_abnormal_olfaction2.02750896
39MP0002735_abnormal_chemical_nociception2.00136000
40MP0000749_muscle_degeneration1.98341957
41MP0003718_maternal_effect1.95256850
42MP0002063_abnormal_learning/memory/cond1.93209223
43MP0002064_seizures1.92278179
44MP0002736_abnormal_nociception_after1.90542178
45MP0002272_abnormal_nervous_system1.86150998
46MP0005409_darkened_coat_color1.85982666
47MP0000358_abnormal_cell_content/1.84731373
48MP0002734_abnormal_mechanical_nocicepti1.82714792
49MP0003787_abnormal_imprinting1.81976669
50MP0000015_abnormal_ear_pigmentation1.78197117
51MP0002067_abnormal_sensory_capabilities1.74194060
52MP0000343_altered_response_to1.70450645
53MP0001727_abnormal_embryo_implantation1.69939384
54MP0006072_abnormal_retinal_apoptosis1.67894682
55MP0002638_abnormal_pupillary_reflex1.64329230
56MP0004270_analgesia1.62150618
57MP0005058_abnormal_lysosome_morphology1.61934035
58MP0003950_abnormal_plasma_membrane1.60573452
59MP0001501_abnormal_sleep_pattern1.60172672
60MP0000778_abnormal_nervous_system1.58393004
61MP0006276_abnormal_autonomic_nervous1.58052535
62MP0005253_abnormal_eye_physiology1.56745137
63MP0001764_abnormal_homeostasis1.52118963
64MP0005174_abnormal_tail_pigmentation1.49606966
65MP0002557_abnormal_social/conspecific_i1.45866837
66MP0001502_abnormal_circadian_rhythm1.45633824
67MP0000350_abnormal_cell_proliferation1.45303050
68MP0004147_increased_porphyrin_level1.44905401
69MP0001881_abnormal_mammary_gland1.42784541
70MP0000026_abnormal_inner_ear1.42174614
71MP0000579_abnormal_nail_morphology1.40624650
72MP0003941_abnormal_skin_development1.38115263
73MP0001853_heart_inflammation1.37018573
74MP0001963_abnormal_hearing_physiology1.35986965
75MP0001970_abnormal_pain_threshold1.34862950
76MP0008058_abnormal_DNA_repair1.33963336
77MP0003698_abnormal_male_reproductive1.32982272
78MP0001661_extended_life_span1.32728244
79MP0000313_abnormal_cell_death1.31868816
80MP0008569_lethality_at_weaning1.30445047
81MP0004742_abnormal_vestibular_system1.28939443
82MP0002009_preneoplasia1.28507766
83MP0002184_abnormal_innervation1.26915648
84MP0010386_abnormal_urinary_bladder1.25641018
85MP0004233_abnormal_muscle_weight1.25422845
86MP0001440_abnormal_grooming_behavior1.25381627
87MP0002277_abnormal_respiratory_mucosa1.25324057
88MP0005330_cardiomyopathy1.23871439
89MP0002876_abnormal_thyroid_physiology1.23144412
90MP0008875_abnormal_xenobiotic_pharmacok1.22353952
91MP0000747_muscle_weakness1.21300995
92MP0001529_abnormal_vocalization1.19332731
93MP0008877_abnormal_DNA_methylation1.18668652
94MP0001730_embryonic_growth_arrest1.18572310
95MP0002752_abnormal_somatic_nervous1.18100977
96MP0009379_abnormal_foot_pigmentation1.17864207
97MP0003283_abnormal_digestive_organ1.17695485
98MP0000569_abnormal_digit_pigmentation1.16849236
99MP0003123_paternal_imprinting1.16698475
100MP0003656_abnormal_erythrocyte_physiolo1.16564525
101MP0004381_abnormal_hair_follicle1.16554536
102MP0002160_abnormal_reproductive_system1.15038629
103MP0005332_abnormal_amino_acid1.14611450
104MP0002733_abnormal_thermal_nociception1.13145013
105MP0002882_abnormal_neuron_morphology1.11775544
106MP0005165_increased_susceptibility_to1.09486200
107MP0010307_abnormal_tumor_latency1.08865984
108MP0002938_white_spotting1.07710210
109MP0009333_abnormal_splenocyte_physiolog1.06647538
110MP0001697_abnormal_embryo_size1.06033216
111MP0001905_abnormal_dopamine_level1.04186791
112MP0001485_abnormal_pinna_reflex1.02619213
113MP0003221_abnormal_cardiomyocyte_apopto1.02487900
114MP0002139_abnormal_hepatobiliary_system1.02366861
115MP0000631_abnormal_neuroendocrine_gland1.01877669
116MP0009840_abnormal_foam_cell1.01827451
117MP0005501_abnormal_skin_physiology0.99216741
118MP0000955_abnormal_spinal_cord0.98356605
119MP0002163_abnormal_gland_morphology0.97995441
120MP0003195_calcinosis0.96724233
121MP0003879_abnormal_hair_cell0.94921625
122MP0002269_muscular_atrophy0.94902111
123MP0004924_abnormal_behavior0.94321528
124MP0005386_behavior/neurological_phenoty0.94321528
125MP0001542_abnormal_bone_strength0.91802449
126MP0005394_taste/olfaction_phenotype0.91122790
127MP0005499_abnormal_olfactory_system0.91122790
128MP0000049_abnormal_middle_ear0.90783769
129MP0005319_abnormal_enzyme/_coenzyme0.90039709
130MP0002080_prenatal_lethality0.89179817
131MP0001929_abnormal_gametogenesis0.89081443
132MP0002019_abnormal_tumor_incidence0.88797186
133MP0002148_abnormal_hypersensitivity_rea0.88428389
134MP0005379_endocrine/exocrine_gland_phen0.88279993
135MP0005623_abnormal_meninges_morphology0.87314829
136MP0002066_abnormal_motor_capabilities/c0.86760752
137MP0002229_neurodegeneration0.85415733
138MP0002837_dystrophic_cardiac_calcinosis0.84531491
139MP0009697_abnormal_copulation0.83986625
140MP0000371_diluted_coat_color0.82158274
141MP0002090_abnormal_vision0.81690723
142MP0000759_abnormal_skeletal_muscle0.79112292
143MP0005266_abnormal_metabolism0.79044963
144MP0005670_abnormal_white_adipose0.78692106
145MP0000678_abnormal_parathyroid_gland0.78216662
146MP0002822_catalepsy0.78151722
147MP0005075_abnormal_melanosome_morpholog0.78118418
148MP0003011_delayed_dark_adaptation0.77207409
149MP0005636_abnormal_mineral_homeostasis0.77117225
150MP0005084_abnormal_gallbladder_morpholo0.76772744
151MP0005195_abnormal_posterior_eye0.76209356
152MP0001186_pigmentation_phenotype0.75993000
153MP0003633_abnormal_nervous_system0.75960706
154MP0005389_reproductive_system_phenotype0.75932458
155MP0003938_abnormal_ear_development0.75864193
156MP0008260_abnormal_autophagy0.75797036
157MP0002095_abnormal_skin_pigmentation0.75233032
158MP0004885_abnormal_endolymph0.74909793
159MP0008789_abnormal_olfactory_epithelium0.74234625
160MP0005584_abnormal_enzyme/coenzyme_acti0.72899689
161MP0002210_abnormal_sex_determination0.72624280
162MP0000858_altered_metastatic_potential0.72441467
163MP0005384_cellular_phenotype0.72286745
164MP0008995_early_reproductive_senescence0.72260577
165MP0000627_abnormal_mammary_gland0.71739634
166MP0000750_abnormal_muscle_regeneration0.69504961
167MP0004145_abnormal_muscle_electrophysio0.68679282
168MP0000462_abnormal_digestive_system0.68103180
169MP0008057_abnormal_DNA_replication0.67243188
170MP0001672_abnormal_embryogenesis/_devel0.66192846
171MP0005380_embryogenesis_phenotype0.66192846
172MP0004811_abnormal_neuron_physiology0.66021680
173MP0008873_increased_physiological_sensi0.65907599
174MP0005395_other_phenotype0.65789121
175MP0002751_abnormal_autonomic_nervous0.65642381
176MP0009250_abnormal_appendicular_skeleto0.65475654
177MP0001324_abnormal_eye_pigmentation0.65304045
178MP0005193_abnormal_anterior_eye0.64775137
179MP0005647_abnormal_sex_gland0.63805730
180MP0005397_hematopoietic_system_phenotyp0.63505365
181MP0001545_abnormal_hematopoietic_system0.63505365
182MP0005365_abnormal_bile_salt0.62605337
183MP0001145_abnormal_male_reproductive0.62346299
184MP0005376_homeostasis/metabolism_phenot0.61953679
185MP0008872_abnormal_physiological_respon0.61001693
186MP0000681_abnormal_thyroid_gland0.60706676

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.88017963
2Abnormal mitochondria in muscle tissue (HP:0008316)5.59167778
3Acute encephalopathy (HP:0006846)5.25875292
4Febrile seizures (HP:0002373)5.02268993
5Mitochondrial inheritance (HP:0001427)4.95544348
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.90021910
7Absent/shortened dynein arms (HP:0200106)4.90021910
8Progressive macrocephaly (HP:0004481)4.82910855
9Focal motor seizures (HP:0011153)4.79130871
10Increased CSF lactate (HP:0002490)4.73615555
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.52567241
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.52567241
13Increased hepatocellular lipid droplets (HP:0006565)4.35334475
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.18322798
15Lipid accumulation in hepatocytes (HP:0006561)4.17332869
16Cerebral edema (HP:0002181)4.17238233
17Increased serum pyruvate (HP:0003542)4.08942285
18Hepatocellular necrosis (HP:0001404)4.04400449
19Hepatic necrosis (HP:0002605)4.01192641
20Renal Fanconi syndrome (HP:0001994)3.96149320
21Increased intramyocellular lipid droplets (HP:0012240)3.86562578
22Abnormality of glycolysis (HP:0004366)3.82807621
23Abnormal respiratory epithelium morphology (HP:0012253)3.81148266
24Abnormal respiratory motile cilium morphology (HP:0005938)3.81148266
253-Methylglutaconic aciduria (HP:0003535)3.75253209
26Medial flaring of the eyebrow (HP:0010747)3.63850457
27Lactic acidosis (HP:0003128)3.61937285
28Increased serum lactate (HP:0002151)3.60680262
29Congenital stationary night blindness (HP:0007642)3.57898233
30Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52532808
31Optic nerve hypoplasia (HP:0000609)3.51964228
32Respiratory failure (HP:0002878)3.46002253
33Increased muscle lipid content (HP:0009058)3.43611268
34Abnormal ciliary motility (HP:0012262)3.39595398
35Exercise intolerance (HP:0003546)3.37042579
36Aplasia/Hypoplasia of the sacrum (HP:0008517)3.35110599
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.27000209
38Gait imbalance (HP:0002141)3.19065185
39Abnormal respiratory motile cilium physiology (HP:0012261)3.18619967
40Congenital primary aphakia (HP:0007707)3.14590427
41Type I transferrin isoform profile (HP:0003642)3.13104732
42Generalized aminoaciduria (HP:0002909)3.08328559
43Exertional dyspnea (HP:0002875)3.05515167
44Hyperalaninemia (HP:0003348)3.04767795
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.04767795
46Abnormality of alanine metabolism (HP:0010916)3.04767795
47Macrocytic anemia (HP:0001972)3.04274953
48Septo-optic dysplasia (HP:0100842)3.02526220
49Epileptic encephalopathy (HP:0200134)2.96666043
50Abnormality of cells of the erythroid lineage (HP:0012130)2.93143991
51Reduced antithrombin III activity (HP:0001976)2.92747578
52Nephrogenic diabetes insipidus (HP:0009806)2.91470956
53Chromsome breakage (HP:0040012)2.90144085
54Abnormality of placental membranes (HP:0011409)2.89614169
55Amniotic constriction ring (HP:0009775)2.89614169
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.84697113
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.84254339
58Abnormality of the anterior horn cell (HP:0006802)2.78827303
59Degeneration of anterior horn cells (HP:0002398)2.78827303
60Tubulointerstitial nephritis (HP:0001970)2.73878310
61Progressive cerebellar ataxia (HP:0002073)2.70683357
62Abnormal number of erythroid precursors (HP:0012131)2.69775976
63Leukodystrophy (HP:0002415)2.69597505
64Decreased central vision (HP:0007663)2.65467666
65Poor coordination (HP:0002370)2.57670165
66Nausea (HP:0002018)2.57664315
67Aplastic anemia (HP:0001915)2.55202341
68Abnormality of methionine metabolism (HP:0010901)2.54744055
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.53454432
70Abnormal glycosylation (HP:0012345)2.51350798
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51350798
72Abnormal protein N-linked glycosylation (HP:0012347)2.51350798
73Abnormal protein glycosylation (HP:0012346)2.51350798
74Respiratory difficulties (HP:0002880)2.50310530
75Microvesicular hepatic steatosis (HP:0001414)2.42544904
76Congenital sensorineural hearing impairment (HP:0008527)2.41577032
77Lethargy (HP:0001254)2.38332034
78Broad-based gait (HP:0002136)2.37672664
79CNS demyelination (HP:0007305)2.36119105
80Gaze-evoked nystagmus (HP:0000640)2.35950587
81Genital tract atresia (HP:0001827)2.34880269
82Stomatitis (HP:0010280)2.34583765
83Vaginal atresia (HP:0000148)2.33211717
84Ragged-red muscle fibers (HP:0003200)2.31832971
85Concave nail (HP:0001598)2.30221043
86Median cleft lip (HP:0000161)2.30168608
87Methylmalonic aciduria (HP:0012120)2.29874512
88Chronic hepatic failure (HP:0100626)2.28018167
89Microretrognathia (HP:0000308)2.27124101
90Attenuation of retinal blood vessels (HP:0007843)2.25338562
91Abnormality of DNA repair (HP:0003254)2.24374962
92Absent speech (HP:0001344)2.23537869
93Abnormalities of placenta or umbilical cord (HP:0001194)2.23348705
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22229985
95Progressive muscle weakness (HP:0003323)2.22139535
96Focal seizures (HP:0007359)2.20836230
97Aplasia/Hypoplasia of the lens (HP:0008063)2.20729015
98Optic disc pallor (HP:0000543)2.20325442
99True hermaphroditism (HP:0010459)2.20245738
100Testicular atrophy (HP:0000029)2.19844145
101Abnormality of renal resorption (HP:0011038)2.18815272
102Rough bone trabeculation (HP:0100670)2.14954837
103Atonic seizures (HP:0010819)2.14181050
104Duplicated collecting system (HP:0000081)2.14178285
105Palpitations (HP:0001962)2.12658160
106Fair hair (HP:0002286)2.12166361
107Conjunctival hamartoma (HP:0100780)2.11569143
108Sparse eyelashes (HP:0000653)2.11547051
109Pallor (HP:0000980)2.11216504
110Hypokinesia (HP:0002375)2.11190942
111Intestinal atresia (HP:0011100)2.09530408
112Nephronophthisis (HP:0000090)2.09383644
113Prostate neoplasm (HP:0100787)2.09117758
114Abnormality of the umbilical cord (HP:0010881)2.08510795
115Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.07945503
116Cerebral hypomyelination (HP:0006808)2.07920137
117Absent septum pellucidum (HP:0001331)2.07322823
118Fetal akinesia sequence (HP:0001989)2.07025991
119Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05120006
120Abnormality of urine glucose concentration (HP:0011016)2.04984222
121Glycosuria (HP:0003076)2.04984222
122Abnormality of the renal collecting system (HP:0004742)2.02530165
123Pancreatic fibrosis (HP:0100732)2.02209249
124Reduced subcutaneous adipose tissue (HP:0003758)2.01784711
125Hyperventilation (HP:0002883)2.01282365
126Pancytopenia (HP:0001876)2.00465153
127Abnormality of serum amino acid levels (HP:0003112)1.99292694
128Nemaline bodies (HP:0003798)1.98946049
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97735761
130Dicarboxylic aciduria (HP:0003215)1.97735761
131Generalized hypopigmentation of hair (HP:0011358)1.96884491
132Hypothermia (HP:0002045)1.96334138
133Abnormal hair whorl (HP:0010721)1.96137036
134Postaxial foot polydactyly (HP:0001830)1.95507057
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.94978268
136Short middle phalanx of the 5th finger (HP:0004220)1.94148094
137Abnormality of the renal medulla (HP:0100957)1.93410630
138Rhabdomyolysis (HP:0003201)1.91296463
139Reticulocytopenia (HP:0001896)1.90495523
140Osteomalacia (HP:0002749)1.90460393
141Emotional lability (HP:0000712)1.90117912
142Decreased lacrimation (HP:0000633)1.89894568
143Pancreatic cysts (HP:0001737)1.89757815
144Short tibia (HP:0005736)1.87587556
145Abnormal rod and cone electroretinograms (HP:0008323)1.87441394
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.86935130
147Abnormal umbilical cord blood vessels (HP:0011403)1.86791612
148Single umbilical artery (HP:0001195)1.86791612
149Abnormality of the fetal cardiovascular system (HP:0010948)1.86791612
150Upper limb muscle weakness (HP:0003484)1.84863640
151Postaxial hand polydactyly (HP:0001162)1.82112838
152Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.81680825
153Secondary amenorrhea (HP:0000869)1.81284630
154Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81268650
155Megaloblastic anemia (HP:0001889)1.80658501
156Oral leukoplakia (HP:0002745)1.80399695
157Abnormality of the septum pellucidum (HP:0007375)1.80021392
158Generalized tonic-clonic seizures (HP:0002069)1.79729614
159Aganglionic megacolon (HP:0002251)1.79560400
160Inability to walk (HP:0002540)1.79210582
161Acute lymphatic leukemia (HP:0006721)1.78870363
162Myokymia (HP:0002411)1.78600173
163Increased IgM level (HP:0003496)1.77973507
164Aplasia cutis congenita (HP:0001057)1.77615460
165Abnormality of the tricuspid valve (HP:0001702)1.76989188
166Nonprogressive disorder (HP:0003680)1.76897552
167Poor head control (HP:0002421)1.76658046
168Neoplasm of head and neck (HP:0012288)1.76122458
169Esophageal neoplasm (HP:0100751)1.76122458
170Abnormality of the ileum (HP:0001549)1.75728355
171X-linked dominant inheritance (HP:0001423)1.75687046
172Protruding tongue (HP:0010808)1.75594276
173Abnormality of the preputium (HP:0100587)1.75075770
174Congenital ichthyosiform erythroderma (HP:0007431)1.74715087
175Rhinitis (HP:0012384)1.74072364
176Muscle fiber inclusion bodies (HP:0100299)1.73910499
177Abnormality of chromosome stability (HP:0003220)1.73671503
178Absence seizures (HP:0002121)1.73221745
179Abnormality of incisor morphology (HP:0011063)1.73146137
180Astigmatism (HP:0000483)1.72836784
181Male pseudohermaphroditism (HP:0000037)1.69905520
182Symphalangism affecting the phalanges of the hand (HP:0009773)1.68981303
183Midline defect of the nose (HP:0004122)1.68724797
184Small hand (HP:0200055)1.68652064
185Type 2 muscle fiber atrophy (HP:0003554)1.68311050
186Conical tooth (HP:0000698)1.67420004
187Clubbing of toes (HP:0100760)1.65320994
188Preaxial hand polydactyly (HP:0001177)1.64478156
189Increased corneal curvature (HP:0100692)1.62526198
190Keratoconus (HP:0000563)1.62526198
191Congenital hepatic fibrosis (HP:0002612)1.62251118
192Thyroid-stimulating hormone excess (HP:0002925)1.60215942
193Alacrima (HP:0000522)1.58061849
194Retinal dysplasia (HP:0007973)1.55935708
195Patchy hypopigmentation of hair (HP:0011365)1.55615238
196White forelock (HP:0002211)1.54983474
197Meckel diverticulum (HP:0002245)1.54738384
198Abnormality of the nasal septum (HP:0000419)1.53966353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.44502394
2BUB14.59114868
3CASK4.54210191
4TNIK3.73879930
5EIF2AK13.36254067
6VRK23.01847574
7PBK2.94070061
8NEK12.91772381
9MAP2K72.80055648
10TAOK32.48576274
11EIF2AK32.43644136
12MST42.43631085
13SRPK12.39169776
14NTRK32.37720886
15EPHA42.29589483
16PRPF4B2.25621336
17PINK12.23482334
18YES12.17690315
19BCKDK2.11609057
20LIMK12.04547478
21CDC72.03816032
22PLK41.95191750
23PIM21.94729801
24TESK11.94654126
25AKT31.88973238
26TTK1.85287730
27INSRR1.83871398
28SCYL21.76976289
29PDK31.76766774
30PDK41.76766774
31IRAK31.71423094
32CDK31.69202585
33WEE11.61441130
34EIF2AK21.60306132
35ARAF1.57202717
36ZAK1.54819881
37RIPK41.54599665
38MUSK1.53561908
39MKNK21.46946574
40ABL21.45701500
41SIK31.42291967
42MAP3K41.41797719
43PAK41.39963017
44MAP3K61.37349830
45MAPK151.30099686
46PDK21.29034101
47ADRBK21.27967203
48TESK21.27945274
49PLK31.25839928
50NEK61.24131983
51TXK1.22593165
52MAPK131.21938054
53TSSK61.20877339
54PLK11.20772082
55BMPR21.19969108
56GRK71.14263551
57TNK21.14222741
58FGR1.13304050
59STK161.12142173
60CSNK1G31.11508089
61ICK1.10120192
62GRK11.08454353
63BRAF1.07793910
64MYLK1.07501114
65BRSK11.07299530
66ILK1.06350384
67SGK21.05906923
68MARK11.05191072
69AURKA1.04629367
70MAP3K120.97630984
71TRIM280.96464472
72AURKB0.94696861
73PLK20.92892021
74NTRK20.92733481
75CAMK2A0.92288791
76STK380.91954442
77BMPR1B0.88103882
78SGK4940.85672373
79SGK2230.85672373
80PKN10.84600673
81MOS0.83578649
82OXSR10.83192197
83MST1R0.82004579
84DAPK10.81219361
85CAMK10.81053345
86PRKD20.81006611
87CSNK1A1L0.80877144
88BRSK20.80032894
89IRAK10.75493984
90IRAK20.73827185
91WNK30.73343809
92EPHB20.72394402
93PRKCE0.71667397
94SGK10.71532359
95DDR20.71408215
96DAPK30.70645561
97SIK20.70348056
98CSNK2A20.69693769
99CDK190.69200628
100CSNK1G10.69095792
101PHKG20.69032472
102PHKG10.69032472
103CSNK2A10.68847044
104IRAK40.68086528
105MAP3K80.68070159
106CDK70.67421497
107PRKCG0.65902503
108CDK80.64728395
109NME10.64658740
110UHMK10.64538881
111CSNK1G20.64448534
112RPS6KB20.64371786
113STK100.63716175
114CAMK2B0.63711064
115MAP3K30.63676604
116STK38L0.63386318
117TAOK20.62459881
118STK40.61636487
119NUAK10.61173450
120MAP3K140.60014634
121CDK50.58772385
122PIK3CG0.58583650
123CAMK2D0.58382792
124ATR0.58369445
125KDR0.58067725
126PAK10.57275498
127ERBB40.56918929
128DAPK20.56259910
129TAF10.55850472
130DYRK30.55539275
131TLK10.55496386
132STK390.55152841
133CHEK10.54661494
134FES0.54361357
135CDC42BPA0.52599000
136CAMK2G0.51249025
137DYRK1A0.50435225
138RPS6KA40.49928542
139WNK10.49858451
140MINK10.48644105
141MAP2K40.47376606
142PRKG10.47134918
143STK30.45342178
144AKT20.44193734
145GRK50.44147063
146PRKACA0.43906754
147CHEK20.43221230
148MKNK10.42645984
149MAPKAPK30.42066107
150MAPK70.41166722
151CLK10.40640895
152CCNB10.40121099
153LRRK20.39874868
154PRKCI0.39466472
155BCR0.38909212
156VRK10.38382425
157RPS6KA50.37801965
158SGK30.37248384
159BRD40.37024429
160TEC0.36431516
161ADRBK10.36121429
162LYN0.35573087
163OBSCN0.35063681
164MAPK100.33957731
165STK110.32268612
166EPHA20.30135402
167PRKG20.28252983
168ATM0.26993899
169PAK20.26436505
170ERBB30.26371965
171CDK140.25470093
172MAP4K20.24305510
173RAF10.22588461
174CSNK1E0.22146643
175TGFBR20.20211038

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.53415727
2Nicotine addiction_Homo sapiens_hsa050334.39589592
3Ribosome_Homo sapiens_hsa030104.14457559
4Phototransduction_Homo sapiens_hsa047443.54030265
5DNA replication_Homo sapiens_hsa030303.21754397
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74860761
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69946268
8Mismatch repair_Homo sapiens_hsa034302.69079919
9Morphine addiction_Homo sapiens_hsa050322.63560163
10Protein export_Homo sapiens_hsa030602.60318287
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.58795292
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56209407
13Taste transduction_Homo sapiens_hsa047422.54538907
14RNA polymerase_Homo sapiens_hsa030202.47096823
15Synaptic vesicle cycle_Homo sapiens_hsa047212.35923883
16Glutamatergic synapse_Homo sapiens_hsa047242.31397208
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24099498
18Fanconi anemia pathway_Homo sapiens_hsa034602.16723094
19GABAergic synapse_Homo sapiens_hsa047272.12502424
20Pyrimidine metabolism_Homo sapiens_hsa002402.08604835
21Circadian entrainment_Homo sapiens_hsa047132.08472691
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06199306
23Olfactory transduction_Homo sapiens_hsa047402.04183380
24Collecting duct acid secretion_Homo sapiens_hsa049661.95178280
25One carbon pool by folate_Homo sapiens_hsa006701.94950233
26Serotonergic synapse_Homo sapiens_hsa047261.94127957
27Base excision repair_Homo sapiens_hsa034101.91549918
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85158436
29Calcium signaling pathway_Homo sapiens_hsa040201.82402476
30Amphetamine addiction_Homo sapiens_hsa050311.75915013
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74420163
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73589483
33Spliceosome_Homo sapiens_hsa030401.73259790
34Salivary secretion_Homo sapiens_hsa049701.72196487
35Folate biosynthesis_Homo sapiens_hsa007901.72027938
36Oxidative phosphorylation_Homo sapiens_hsa001901.67160990
37Insulin secretion_Homo sapiens_hsa049111.66264068
38Sulfur relay system_Homo sapiens_hsa041221.64789981
39Fatty acid biosynthesis_Homo sapiens_hsa000611.61899119
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59581990
41Sulfur metabolism_Homo sapiens_hsa009201.56667728
42RNA transport_Homo sapiens_hsa030131.52814115
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44751165
44Pyruvate metabolism_Homo sapiens_hsa006201.39375692
45Circadian rhythm_Homo sapiens_hsa047101.36176611
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31060611
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30940553
48Fatty acid elongation_Homo sapiens_hsa000621.29588163
49Carbon metabolism_Homo sapiens_hsa012001.27907821
50Dopaminergic synapse_Homo sapiens_hsa047281.25529446
51Propanoate metabolism_Homo sapiens_hsa006401.24604683
52RNA degradation_Homo sapiens_hsa030181.20462917
53Long-term potentiation_Homo sapiens_hsa047201.20285824
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19719948
55Cell cycle_Homo sapiens_hsa041101.17452101
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15618773
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15494360
58Glutathione metabolism_Homo sapiens_hsa004801.14426778
59Cholinergic synapse_Homo sapiens_hsa047251.14179716
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14038984
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12443350
62Cardiac muscle contraction_Homo sapiens_hsa042601.12040424
63Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11242050
64cAMP signaling pathway_Homo sapiens_hsa040241.10862576
65Huntingtons disease_Homo sapiens_hsa050161.09379296
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.07772873
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07508415
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07483844
69Renin secretion_Homo sapiens_hsa049241.07194422
70Long-term depression_Homo sapiens_hsa047301.05876197
71SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05132912
72Rheumatoid arthritis_Homo sapiens_hsa053231.04187932
73Alzheimers disease_Homo sapiens_hsa050101.03013142
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00005432
75Homologous recombination_Homo sapiens_hsa034400.97739580
76Biosynthesis of amino acids_Homo sapiens_hsa012300.97320003
77Cocaine addiction_Homo sapiens_hsa050300.95593277
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.95183274
79Basal transcription factors_Homo sapiens_hsa030220.95081304
80Sphingolipid metabolism_Homo sapiens_hsa006000.94975038
81Axon guidance_Homo sapiens_hsa043600.93953786
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88156667
83Wnt signaling pathway_Homo sapiens_hsa043100.85757146
84Pancreatic secretion_Homo sapiens_hsa049720.84975177
85Ether lipid metabolism_Homo sapiens_hsa005650.80110709
86Metabolic pathways_Homo sapiens_hsa011000.79922346
87Gastric acid secretion_Homo sapiens_hsa049710.79791242
88Parkinsons disease_Homo sapiens_hsa050120.79022532
89Vitamin B6 metabolism_Homo sapiens_hsa007500.75900098
90Mineral absorption_Homo sapiens_hsa049780.75862298
91Non-homologous end-joining_Homo sapiens_hsa034500.74437677
92Oxytocin signaling pathway_Homo sapiens_hsa049210.73890177
93Arachidonic acid metabolism_Homo sapiens_hsa005900.73473242
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73043125
95Autoimmune thyroid disease_Homo sapiens_hsa053200.71554093
96Galactose metabolism_Homo sapiens_hsa000520.71551096
97Inositol phosphate metabolism_Homo sapiens_hsa005620.69745560
98Pentose phosphate pathway_Homo sapiens_hsa000300.69047124
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68798925
100Hedgehog signaling pathway_Homo sapiens_hsa043400.67704571
101ErbB signaling pathway_Homo sapiens_hsa040120.67427900
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67364469
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67320211
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64706718
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64649245
106Fructose and mannose metabolism_Homo sapiens_hsa000510.63761831
107Choline metabolism in cancer_Homo sapiens_hsa052310.63245743
108p53 signaling pathway_Homo sapiens_hsa041150.61082076
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60459909
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60393289
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59571509
112N-Glycan biosynthesis_Homo sapiens_hsa005100.59181347
113Ras signaling pathway_Homo sapiens_hsa040140.57999848
114African trypanosomiasis_Homo sapiens_hsa051430.57080306
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56549406
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54763946
117Selenocompound metabolism_Homo sapiens_hsa004500.53562237
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51773772
119Melanogenesis_Homo sapiens_hsa049160.51601206
120Peroxisome_Homo sapiens_hsa041460.51359177
121Linoleic acid metabolism_Homo sapiens_hsa005910.50683325
122Arginine and proline metabolism_Homo sapiens_hsa003300.50633571
123Phenylalanine metabolism_Homo sapiens_hsa003600.50197504
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49961468
125Vibrio cholerae infection_Homo sapiens_hsa051100.49705624
126MAPK signaling pathway_Homo sapiens_hsa040100.48711477
127Epstein-Barr virus infection_Homo sapiens_hsa051690.48485446
128Vitamin digestion and absorption_Homo sapiens_hsa049770.47946869
129Steroid biosynthesis_Homo sapiens_hsa001000.47178549
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45481272
131Graft-versus-host disease_Homo sapiens_hsa053320.45194608
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45141596
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.44997941
134Tyrosine metabolism_Homo sapiens_hsa003500.44910416
135Basal cell carcinoma_Homo sapiens_hsa052170.43443420
136Oocyte meiosis_Homo sapiens_hsa041140.43146361
137Purine metabolism_Homo sapiens_hsa002300.41870432
138Ovarian steroidogenesis_Homo sapiens_hsa049130.41824359
139Dorso-ventral axis formation_Homo sapiens_hsa043200.41590327
140GnRH signaling pathway_Homo sapiens_hsa049120.39015063
141Type I diabetes mellitus_Homo sapiens_hsa049400.38972896
142Asthma_Homo sapiens_hsa053100.38602653
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37526951
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37473389
145Allograft rejection_Homo sapiens_hsa053300.37295323
146Type II diabetes mellitus_Homo sapiens_hsa049300.36908183
147Fatty acid metabolism_Homo sapiens_hsa012120.36429261
148Fatty acid degradation_Homo sapiens_hsa000710.35565074
149Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35383026
150ABC transporters_Homo sapiens_hsa020100.34604575
151Gap junction_Homo sapiens_hsa045400.34540411
152Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34101967
153mRNA surveillance pathway_Homo sapiens_hsa030150.33833682
154Melanoma_Homo sapiens_hsa052180.32718736
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.31787075
156Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31428176
157Systemic lupus erythematosus_Homo sapiens_hsa053220.31402516
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.31316450
159Legionellosis_Homo sapiens_hsa051340.30100845
160Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28408940
161Nucleotide excision repair_Homo sapiens_hsa034200.27873368
162Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27012843
163Hematopoietic cell lineage_Homo sapiens_hsa046400.26981639
164Phagosome_Homo sapiens_hsa041450.26652752
165Cyanoamino acid metabolism_Homo sapiens_hsa004600.24698148
166Lysosome_Homo sapiens_hsa041420.24175494
167Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21159568
168Chemical carcinogenesis_Homo sapiens_hsa052040.18015665
169Shigellosis_Homo sapiens_hsa051310.15531154
170Butanoate metabolism_Homo sapiens_hsa006500.12904547
171Tryptophan metabolism_Homo sapiens_hsa003800.12475801
172beta-Alanine metabolism_Homo sapiens_hsa004100.11049535
173Bladder cancer_Homo sapiens_hsa052190.08051933
174Other glycan degradation_Homo sapiens_hsa005110.06660139
175Steroid hormone biosynthesis_Homo sapiens_hsa001400.06466778

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