GLRX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)6.18527466
2heme biosynthetic process (GO:0006783)5.98924442
3oxygen transport (GO:0015671)5.93579975
4hemoglobin metabolic process (GO:0020027)5.77597408
5protoporphyrinogen IX biosynthetic process (GO:0006782)5.67867800
6gas transport (GO:0015669)5.57773382
7porphyrin-containing compound biosynthetic process (GO:0006779)5.45278386
8innate immune response in mucosa (GO:0002227)5.32139661
9daunorubicin metabolic process (GO:0044597)5.22419769
10polyketide metabolic process (GO:0030638)5.22419769
11doxorubicin metabolic process (GO:0044598)5.22419769
12heme metabolic process (GO:0042168)5.00472470
13antibacterial humoral response (GO:0019731)4.95636014
14tetrapyrrole biosynthetic process (GO:0033014)4.83119357
15porphyrin-containing compound metabolic process (GO:0006778)4.76444164
16antimicrobial humoral response (GO:0019730)4.67033176
17mucosal immune response (GO:0002385)4.23343751
18sulfur amino acid catabolic process (GO:0000098)4.12183071
19erythrocyte development (GO:0048821)4.12061829
20pteridine-containing compound biosynthetic process (GO:0042559)4.05084276
21lysine catabolic process (GO:0006554)4.01057636
22lysine metabolic process (GO:0006553)4.01057636
23DNA deamination (GO:0045006)3.96587154
24peptidyl-lysine dimethylation (GO:0018027)3.92372127
25ribosomal small subunit biogenesis (GO:0042274)3.92259579
26protein localization to kinetochore (GO:0034501)3.90865819
27organ or tissue specific immune response (GO:0002251)3.82798685
28folic acid-containing compound biosynthetic process (GO:0009396)3.82614584
29nucleosome assembly (GO:0006334)3.76815004
30chromatin assembly (GO:0031497)3.76520193
31cysteine metabolic process (GO:0006534)3.75912507
32coenzyme catabolic process (GO:0009109)3.75874281
33aminoglycoside antibiotic metabolic process (GO:0030647)3.68450809
34L-phenylalanine metabolic process (GO:0006558)3.67010198
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.67010198
36DNA replication checkpoint (GO:0000076)3.66875840
37protein complex disassembly (GO:0043241)3.63276444
38viral transcription (GO:0019083)3.62701390
39cellular modified amino acid catabolic process (GO:0042219)3.59411757
40heme transport (GO:0015886)3.54879644
41cofactor catabolic process (GO:0051187)3.49660988
42translational termination (GO:0006415)3.49341029
43ribosomal small subunit assembly (GO:0000028)3.47119740
44formation of translation preinitiation complex (GO:0001731)3.46968704
45DNA topological change (GO:0006265)3.45932998
46nuclear pore complex assembly (GO:0051292)3.45207278
47maternal placenta development (GO:0001893)3.42489862
48folic acid metabolic process (GO:0046655)3.42188499
49pigment biosynthetic process (GO:0046148)3.38542147
50macromolecular complex disassembly (GO:0032984)3.37949876
51protein localization to chromosome, centromeric region (GO:0071459)3.36258007
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.31574357
53L-phenylalanine catabolic process (GO:0006559)3.31574357
54tetrapyrrole metabolic process (GO:0033013)3.31441386
55glycine metabolic process (GO:0006544)3.30105777
56nucleosome organization (GO:0034728)3.26316837
57DNA replication-dependent nucleosome assembly (GO:0006335)3.24918764
58DNA replication-dependent nucleosome organization (GO:0034723)3.24918764
59histone lysine demethylation (GO:0070076)3.24499920
60regulation of RNA export from nucleus (GO:0046831)3.23780916
61rRNA modification (GO:0000154)3.22553644
62regulation of histone H3-K9 methylation (GO:0051570)3.19278428
63embryonic process involved in female pregnancy (GO:0060136)3.18696018
64regulation of response to osmotic stress (GO:0047484)3.17531264
65protein-DNA complex assembly (GO:0065004)3.17179553
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15627476
67rRNA transcription (GO:0009303)3.15500719
68translational elongation (GO:0006414)3.12843507
69erythrocyte maturation (GO:0043249)3.12071854
70glyoxylate metabolic process (GO:0046487)3.11793611
71nucleobase-containing small molecule interconversion (GO:0015949)3.11234205
72pseudouridine synthesis (GO:0001522)3.10902222
73pentose-phosphate shunt (GO:0006098)3.10832139
74response to methylmercury (GO:0051597)3.08482956
75quinone metabolic process (GO:1901661)3.07594560
76protein targeting to ER (GO:0045047)3.07197600
77chromatin assembly or disassembly (GO:0006333)3.07180674
78cellular response to arsenic-containing substance (GO:0071243)3.07022012
79cotranslational protein targeting to membrane (GO:0006613)3.05401716
80histone H3-K36 demethylation (GO:0070544)3.04822868
81histone demethylation (GO:0016577)3.03605576
82mitotic sister chromatid segregation (GO:0000070)3.01978245
83pigment metabolic process (GO:0042440)3.00851897
84rRNA methylation (GO:0031167)3.00505598
85DNA replication initiation (GO:0006270)2.99554820
86regulation of megakaryocyte differentiation (GO:0045652)2.98888367
87negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.98349065
88nuclear pore organization (GO:0006999)2.97957047
89nuclear-transcribed mRNA catabolic process (GO:0000956)2.97648486
90pre-miRNA processing (GO:0031054)2.97373437
91maturation of SSU-rRNA (GO:0030490)2.96549734
92valine metabolic process (GO:0006573)2.95532184
93aromatic amino acid family catabolic process (GO:0009074)2.92722617
94protein localization to endoplasmic reticulum (GO:0070972)2.92600569
95negative regulation of telomerase activity (GO:0051974)2.91974793
96triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.91536318
97serine family amino acid metabolic process (GO:0009069)2.90854293
98establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90367081
99ribonucleoprotein complex biogenesis (GO:0022613)2.90187108
100very-low-density lipoprotein particle assembly (GO:0034379)2.88642024
101epoxygenase P450 pathway (GO:0019373)2.88579351
102regulation of chromatin binding (GO:0035561)2.88557041
103deoxyribose phosphate biosynthetic process (GO:0046385)2.87312135
1042-deoxyribonucleotide biosynthetic process (GO:0009265)2.87312135
105cellular protein complex localization (GO:0034629)2.85948324
106urea cycle (GO:0000050)2.85705503
107DNA unwinding involved in DNA replication (GO:0006268)2.83600305
108protein-DNA complex subunit organization (GO:0071824)2.83193401
109pteridine-containing compound metabolic process (GO:0042558)2.83052437
110mRNA catabolic process (GO:0006402)2.82311707
111mitotic chromosome condensation (GO:0007076)2.81878440
112protein complex localization (GO:0031503)2.81584973
113protein targeting to membrane (GO:0006612)2.81156774
114translational initiation (GO:0006413)2.80981725
115nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80937938
116serine family amino acid biosynthetic process (GO:0009070)2.80139965
117negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.79987277
118ribosome biogenesis (GO:0042254)2.79704250
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.79292372
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78087639
121NADPH regeneration (GO:0006740)2.77286320
122definitive hemopoiesis (GO:0060216)2.76656349
123kynurenine metabolic process (GO:0070189)2.76019408
124drug metabolic process (GO:0017144)2.76009112
125negative regulation of epidermis development (GO:0045683)2.75246562
126protein demethylation (GO:0006482)2.72998698
127protein dealkylation (GO:0008214)2.72998698
128pyrimidine nucleotide catabolic process (GO:0006244)2.72894055
129regulation of mammary gland epithelial cell proliferation (GO:0033599)2.72567014
130negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.72543438
131cofactor biosynthetic process (GO:0051188)2.71886352
132regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71800687
133blood coagulation, intrinsic pathway (GO:0007597)2.71677630
134primary alcohol catabolic process (GO:0034310)2.71206971
135tetrahydrofolate metabolic process (GO:0046653)2.70498779
136RNA catabolic process (GO:0006401)2.69406968
137viral life cycle (GO:0019058)2.68675890
138mitochondrial fusion (GO:0008053)2.68033287
139negative regulation of cell cycle G2/M phase transition (GO:1902750)2.67564607
140ethanol oxidation (GO:0006069)2.66802995
141serine family amino acid catabolic process (GO:0009071)2.66517725
142translation (GO:0006412)2.65939222
143regulation of nucleobase-containing compound transport (GO:0032239)2.65660401
144viral mRNA export from host cell nucleus (GO:0046784)2.64997279
145oxidative phosphorylation (GO:0006119)2.64871027
146one-carbon metabolic process (GO:0006730)2.63934518
147telomere maintenance via semi-conservative replication (GO:0032201)2.63473478
148transcription from mitochondrial promoter (GO:0006390)2.63455388
149deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.62619182
150nitrogen cycle metabolic process (GO:0071941)2.62526236
151DNA strand elongation involved in DNA replication (GO:0006271)2.61915681
152protein autoprocessing (GO:0016540)2.61830790
153deoxyribonucleotide biosynthetic process (GO:0009263)2.61741312
154nucleoside salvage (GO:0043174)2.61442826
155cellular hyperosmotic response (GO:0071474)2.61236319
156mitochondrial DNA replication (GO:0006264)2.60557856
157protein destabilization (GO:0031648)2.60492435
158cellular protein complex disassembly (GO:0043624)2.56613344
159imidazole-containing compound metabolic process (GO:0052803)2.56136080
160urea metabolic process (GO:0019627)2.55245752
161mitochondrion degradation (GO:0000422)2.53074911
162histone H3-K9 demethylation (GO:0033169)2.51682649
1633-UTR-mediated mRNA stabilization (GO:0070935)2.48841103
164dosage compensation (GO:0007549)2.48806914
165CENP-A containing nucleosome assembly (GO:0034080)2.48487869
166keratinization (GO:0031424)2.48333919
167DNA strand elongation (GO:0022616)2.46792646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.88055944
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.56296045
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63893975
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.47535916
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.32741008
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09379023
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09126877
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.00528124
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41639936
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.35812724
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.35452722
12* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33889668
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33855620
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29228332
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.28007165
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21234326
17* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18210993
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15623585
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11137818
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10177342
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.02249249
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.7957144
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.95408366
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.90152030
25CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.88143405
26GATA1_19941826_ChIP-Seq_K562_Human1.86727804
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81953158
28XRN2_22483619_ChIP-Seq_HELA_Human1.76307764
29MYC_22102868_ChIP-Seq_BL_Human1.73973962
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72969145
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67612538
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67612538
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67612538
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63435435
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62128732
36GATA1_22025678_ChIP-Seq_K562_Human1.58804148
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58547289
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56009532
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55536504
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55325751
41DCP1A_22483619_ChIP-Seq_HELA_Human1.54677661
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52681775
43FOXP3_21729870_ChIP-Seq_TREG_Human1.50929982
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.50588922
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49312272
46* GABP_19822575_ChIP-Seq_HepG2_Human1.48837561
47VDR_23849224_ChIP-Seq_CD4+_Human1.46758581
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45919715
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44363204
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43606984
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41283462
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.40177305
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38272981
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37316491
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36517010
56* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35276794
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31401222
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30018028
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29748789
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29081147
61AR_21909140_ChIP-Seq_LNCAP_Human1.28479583
62* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28213974
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28113910
64SCL_19346495_ChIP-Seq_HPC-7_Human1.27935706
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26455350
66GATA2_19941826_ChIP-Seq_K562_Human1.26192497
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25448819
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25367550
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25142246
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24831188
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24401888
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24203858
73VDR_21846776_ChIP-Seq_THP-1_Human1.23073876
74TCF7_22412390_ChIP-Seq_EML_Mouse1.21086936
75* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20849778
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20407460
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.20270819
78TTF2_22483619_ChIP-Seq_HELA_Human1.19924773
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19582029
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.18855398
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18830581
82KDM5A_27292631_Chip-Seq_BREAST_Human1.17799859
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17572209
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17217787
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17079387
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14057095
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13350959
88* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13189518
89* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12793530
90* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11536818
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10750081
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10535206
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07925880
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07841508
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07526740
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06134262
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05711967
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05378446
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04867295
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.03808184
101ZNF263_19887448_ChIP-Seq_K562_Human1.02146240
102OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01443946
103CTCF_21964334_Chip-Seq_Bcells_Human1.00918408
104* GATA1_19941827_ChIP-Seq_MEL_Mouse1.00445780
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00185845
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00141452
107CHD1_26751641_Chip-Seq_LNCaP_Human1.00098440
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99921226
109* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99282031
110CIITA_25753668_ChIP-Seq_RAJI_Human0.99256332
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98252240
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96934466
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.96645120
114RACK7_27058665_Chip-Seq_MCF-7_Human0.96493024
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96103772
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95679486
117VDR_24763502_ChIP-Seq_THP-1_Human0.95156512
118TFEB_21752829_ChIP-Seq_HELA_Human0.95041320
119YY1_22570637_ChIP-Seq_MALME-3M_Human0.93416476
120* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92586781
121LXR_22292898_ChIP-Seq_THP-1_Human0.92555323
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.92528012
123NCOR1_26117541_ChIP-Seq_K562_Human0.92356603
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92287945
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.91983745
126FOXP1_21924763_ChIP-Seq_HESCs_Human0.91892004
127SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90800175
128HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90337882
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89840178
130YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87711890
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87602720
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87547678
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.87248623
134ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85058844
135* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84610816
136MAF_26560356_Chip-Seq_TH1_Human0.79544696
137KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79034168
138MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78635232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo5.03074299
2MP0002139_abnormal_hepatobiliary_system4.54694615
3MP0003806_abnormal_nucleotide_metabolis4.02689431
4MP0005360_urolithiasis3.95229305
5MP0004147_increased_porphyrin_level3.42015251
6MP0005085_abnormal_gallbladder_physiolo3.30288346
7MP0003011_delayed_dark_adaptation2.94844086
8MP0005365_abnormal_bile_salt2.87583091
9MP0004957_abnormal_blastocyst_morpholog2.84196698
10MP0008260_abnormal_autophagy2.83112689
11MP0005451_abnormal_body_composition2.82866108
12MP0006036_abnormal_mitochondrial_physio2.52856319
13MP0008875_abnormal_xenobiotic_pharmacok2.52670182
14MP0006035_abnormal_mitochondrial_morpho2.31908652
15MP0005083_abnormal_biliary_tract2.30971327
16MP0003186_abnormal_redox_activity2.29112893
17MP0004264_abnormal_extraembryonic_tissu2.18662186
18MP0003693_abnormal_embryo_hatching2.11432220
19MP0003705_abnormal_hypodermis_morpholog2.02501610
20MP0010234_abnormal_vibrissa_follicle1.88254259
21MP0005076_abnormal_cell_differentiation1.87127975
22MP0003111_abnormal_nucleus_morphology1.86953719
23MP0002132_abnormal_respiratory_system1.86146688
24MP0002796_impaired_skin_barrier1.77923826
25MP0010329_abnormal_lipoprotein_level1.77854179
26MP0000609_abnormal_liver_physiology1.76874143
27MP0010352_gastrointestinal_tract_polyps1.74288780
28MP0005319_abnormal_enzyme/_coenzyme1.73954634
29MP0008995_early_reproductive_senescence1.71172154
30MP0003941_abnormal_skin_development1.70383438
31MP0003252_abnormal_bile_duct1.65285002
32MP0005075_abnormal_melanosome_morpholog1.63091214
33MP0005636_abnormal_mineral_homeostasis1.62435631
34MP0003077_abnormal_cell_cycle1.62311523
35MP0002396_abnormal_hematopoietic_system1.62029494
36MP0009840_abnormal_foam_cell1.60966214
37MP0008057_abnormal_DNA_replication1.58169959
38MP0005266_abnormal_metabolism1.57287447
39MP0002332_abnormal_exercise_endurance1.52828544
40MP0000490_abnormal_crypts_of1.51494548
41MP0000569_abnormal_digit_pigmentation1.48264875
42MP0002254_reproductive_system_inflammat1.48130861
43MP0003453_abnormal_keratinocyte_physiol1.45962594
44MP0004808_abnormal_hematopoietic_stem1.44885662
45MP0010094_abnormal_chromosome_stability1.42874347
46MP0002163_abnormal_gland_morphology1.42314378
47MP0005332_abnormal_amino_acid1.40932709
48MP0001545_abnormal_hematopoietic_system1.38400230
49MP0005397_hematopoietic_system_phenotyp1.38400230
50MP0006292_abnormal_olfactory_placode1.35448831
51MP0003191_abnormal_cellular_cholesterol1.31219726
52MP0003786_premature_aging1.28187590
53MP0004381_abnormal_hair_follicle1.27460182
54MP0004043_abnormal_pH_regulation1.27454314
55MP0000598_abnormal_liver_morphology1.22310719
56MP0001661_extended_life_span1.19871653
57MP0002970_abnormal_white_adipose1.19114110
58MP0005408_hypopigmentation1.18762395
59MP0002822_catalepsy1.18732893
60MP0003303_peritoneal_inflammation1.17299013
61MP0000747_muscle_weakness1.16177301
62MP0002160_abnormal_reproductive_system1.14023865
63MP0009697_abnormal_copulation1.13792806
64MP0009643_abnormal_urine_homeostasis1.12930347
65MP0005584_abnormal_enzyme/coenzyme_acti1.12851928
66MP0005499_abnormal_olfactory_system1.12821139
67MP0005394_taste/olfaction_phenotype1.12821139
68MP0005220_abnormal_exocrine_pancreas1.11542047
69MP0010307_abnormal_tumor_latency1.11022347
70MP0000350_abnormal_cell_proliferation1.10295767
71MP0000371_diluted_coat_color1.10234680
72MP0000358_abnormal_cell_content/1.09362900
73MP0000733_abnormal_muscle_development1.08663065
74MP0000749_muscle_degeneration1.07520296
75MP0001672_abnormal_embryogenesis/_devel1.07164493
76MP0005380_embryogenesis_phenotype1.07164493
77MP0002088_abnormal_embryonic_growth/wei1.07049060
78MP0003984_embryonic_growth_retardation1.06350598
79MP0001666_abnormal_nutrient_absorption1.05519607
80MP0006054_spinal_hemorrhage1.04608913
81MP0001346_abnormal_lacrimal_gland1.03839166
82MP0003890_abnormal_embryonic-extraembry1.03388105
83MP0001730_embryonic_growth_arrest1.02272669
84MP0000759_abnormal_skeletal_muscle1.00383845
85MP0000313_abnormal_cell_death0.99919341
86MP0002095_abnormal_skin_pigmentation0.99111205
87MP0008932_abnormal_embryonic_tissue0.97811044
88MP0009672_abnormal_birth_weight0.97779104
89MP0005376_homeostasis/metabolism_phenot0.97200852
90MP0002009_preneoplasia0.96580216
91MP0005187_abnormal_penis_morphology0.95979778
92MP0002118_abnormal_lipid_homeostasis0.94205041
93MP0002086_abnormal_extraembryonic_tissu0.93942033
94MP0002269_muscular_atrophy0.93615207
95MP0000015_abnormal_ear_pigmentation0.93218022
96MP0000678_abnormal_parathyroid_gland0.91846257
97MP0005375_adipose_tissue_phenotype0.89522361
98MP0008872_abnormal_physiological_respon0.88426465
99MP0009703_decreased_birth_body0.88155865
100MP0003123_paternal_imprinting0.87698683
101MP0002080_prenatal_lethality0.87618188
102MP0005464_abnormal_platelet_physiology0.87582788
103MP0001764_abnormal_homeostasis0.86180738
104MP0002019_abnormal_tumor_incidence0.85965002
105MP0002138_abnormal_hepatobiliary_system0.85199366
106MP0004130_abnormal_muscle_cell0.84234039
107MP0003868_abnormal_feces_composition0.84222359
108MP0005330_cardiomyopathy0.84050829
109MP0003315_abnormal_perineum_morphology0.83849608
110MP0004087_abnormal_muscle_fiber0.82645799
111MP0002089_abnormal_postnatal_growth/wei0.80330610
112MP0004019_abnormal_vitamin_homeostasis0.78426960
113MP0003763_abnormal_thymus_physiology0.76573303
114MP0009379_abnormal_foot_pigmentation0.76064514
115MP0008058_abnormal_DNA_repair0.75589076
116MP0001697_abnormal_embryo_size0.75339031
117MP0009333_abnormal_splenocyte_physiolog0.75041165
118MP0002722_abnormal_immune_system0.74835909
119MP0002166_altered_tumor_susceptibility0.74761200
120MP0002877_abnormal_melanocyte_morpholog0.74308328
121MP0008775_abnormal_heart_ventricle0.74299809
122MP0008961_abnormal_basal_metabolism0.74064139
123MP0003221_abnormal_cardiomyocyte_apopto0.73918950
124MP0000689_abnormal_spleen_morphology0.73512516
125MP0003195_calcinosis0.73479802
126MP0002971_abnormal_brown_adipose0.73448105
127MP0005384_cellular_phenotype0.73074966
128MP0005621_abnormal_cell_physiology0.72468127
129MP0008770_decreased_survivor_rate0.72081893
130MP0005379_endocrine/exocrine_gland_phen0.72063607
131MP0004233_abnormal_muscle_weight0.71615709
132MP0003942_abnormal_urinary_system0.70906715
133MP0008469_abnormal_protein_level0.69785206
134MP0005257_abnormal_intraocular_pressure0.69563789
135MP0001270_distended_abdomen0.69203620
136MP0005666_abnormal_adipose_tissue0.68704344
137MP0002092_abnormal_eye_morphology0.68441333
138MP0009763_increased_sensitivity_to0.68282446
139MP0004215_abnormal_myocardial_fiber0.67552100
140MP0000750_abnormal_muscle_regeneration0.66200054
141MP0010630_abnormal_cardiac_muscle0.66072881
142MP0005501_abnormal_skin_physiology0.64913689
143MP0002398_abnormal_bone_marrow0.64745576
144MP0009278_abnormal_bone_marrow0.64276756
145MP0008007_abnormal_cellular_replicative0.64173140
146MP0000858_altered_metastatic_potential0.63504110
147MP0004197_abnormal_fetal_growth/weight/0.63232404
148MP0010030_abnormal_orbit_morphology0.61727172
149MP0004858_abnormal_nervous_system0.61166482
150MP0004185_abnormal_adipocyte_glucose0.60697526
151MP0009931_abnormal_skin_appearance0.60537365
152MP0001243_abnormal_dermal_layer0.59829467

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)7.43248553
2Hypochromic microcytic anemia (HP:0004840)5.51717455
3Multiple enchondromatosis (HP:0005701)5.01746266
4Poikilocytosis (HP:0004447)4.59323410
5Abnormality of cells of the erythroid lineage (HP:0012130)4.36812577
6Abnormal number of erythroid precursors (HP:0012131)4.36164508
7Reticulocytosis (HP:0001923)4.29342547
8Acanthocytosis (HP:0001927)3.99392473
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.81840023
10Ragged-red muscle fibers (HP:0003200)3.76224836
11Colitis (HP:0002583)3.75980574
12Hyperbilirubinemia (HP:0002904)3.70863210
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.61627385
14Rectal prolapse (HP:0002035)3.59175552
15Abnormality of reticulocytes (HP:0004312)3.49962013
16Abnormality of nail color (HP:0100643)3.37237969
17Abnormality of the fingertips (HP:0001211)3.35300073
18Abnormality of the distal phalanx of the thumb (HP:0009617)3.24401824
19Progressive muscle weakness (HP:0003323)3.22209771
20Abnormal cartilage morphology (HP:0002763)3.21278548
21Neoplasm of the heart (HP:0100544)3.19099888
22Abnormality of monocarboxylic acid metabolism (HP:0010996)3.19061211
23Reduced antithrombin III activity (HP:0001976)3.14824289
24Cholelithiasis (HP:0001081)3.14093391
25Hypochromic anemia (HP:0001931)3.08838409
26Abnormality of the parietal bone (HP:0002696)3.07894358
27Bilateral microphthalmos (HP:0007633)3.06740662
28Intrahepatic cholestasis (HP:0001406)2.98150977
29Abnormality of the intrinsic pathway (HP:0010989)2.94975473
30Down-sloping shoulders (HP:0200021)2.93281860
31Hyperammonemia (HP:0001987)2.92155284
32Medulloblastoma (HP:0002885)2.89385129
33Hyperinsulinemic hypoglycemia (HP:0000825)2.87862659
34Abnormal gallbladder morphology (HP:0012437)2.84873824
35Testicular atrophy (HP:0000029)2.77021523
36Xanthomatosis (HP:0000991)2.76351833
37Hypobetalipoproteinemia (HP:0003563)2.71252180
38Germ cell neoplasia (HP:0100728)2.70685616
39Aplastic anemia (HP:0001915)2.69061977
40Hypoglycemic coma (HP:0001325)2.67234873
41Deep venous thrombosis (HP:0002625)2.66138136
42Pallor (HP:0000980)2.64033763
43Dicarboxylic aciduria (HP:0003215)2.63325807
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63325807
45Ketosis (HP:0001946)2.63310345
46Hyperglycinuria (HP:0003108)2.62453019
473-Methylglutaconic aciduria (HP:0003535)2.61774100
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58662078
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58662078
50Microcytic anemia (HP:0001935)2.57168264
51Microvesicular hepatic steatosis (HP:0001414)2.52478804
52Paralysis (HP:0003470)2.52381293
53IgM deficiency (HP:0002850)2.50810745
54Short 4th metacarpal (HP:0010044)2.50546457
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50546457
56Microretrognathia (HP:0000308)2.50181447
57Hepatoblastoma (HP:0002884)2.47309114
58Slow saccadic eye movements (HP:0000514)2.45899564
59Petechiae (HP:0000967)2.45593421
60Metabolic acidosis (HP:0001942)2.44770641
61Malnutrition (HP:0004395)2.42325271
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42041355
63Trismus (HP:0000211)2.41801789
64Macrocytic anemia (HP:0001972)2.40510744
65Exercise-induced myalgia (HP:0003738)2.38870061
66Abnormality of the Achilles tendon (HP:0005109)2.37775741
67Cerebral edema (HP:0002181)2.32562551
68Abnormality of glycolysis (HP:0004366)2.31489510
69Increased serum pyruvate (HP:0003542)2.31489510
70Hepatic necrosis (HP:0002605)2.31434712
71Ketoacidosis (HP:0001993)2.30258075
72Abnormality of glycine metabolism (HP:0010895)2.30098523
73Abnormality of serine family amino acid metabolism (HP:0010894)2.30098523
74Deformed sella turcica (HP:0002681)2.27565222
75Abnormality of the 4th metacarpal (HP:0010012)2.27554540
76Diaphragmatic weakness (HP:0009113)2.25329254
77Hyporeflexia of lower limbs (HP:0002600)2.25092292
78Lethargy (HP:0001254)2.24818239
79Rhabdomyosarcoma (HP:0002859)2.24488496
8011 pairs of ribs (HP:0000878)2.23261477
81Prolonged partial thromboplastin time (HP:0003645)2.22448455
82Vomiting (HP:0002013)2.21530587
83Acute encephalopathy (HP:0006846)2.20294919
84Abnormal gallbladder physiology (HP:0012438)2.19613149
85Cholecystitis (HP:0001082)2.19613149
86Increased connective tissue (HP:0009025)2.18669485
87Increased muscle lipid content (HP:0009058)2.17968057
88Difficulty running (HP:0009046)2.17420550
89Achilles tendon contracture (HP:0001771)2.17379989
90Increased serum lactate (HP:0002151)2.15305632
91Gout (HP:0001997)2.15228369
92Nausea (HP:0002018)2.14291118
93Polycythemia (HP:0001901)2.13012496
94Abnormality of pyrimidine metabolism (HP:0004353)2.12902187
95Syringomyelia (HP:0003396)2.10533236
96Spinal cord lesions (HP:0100561)2.10533236
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10170828
98Gastrointestinal inflammation (HP:0004386)2.10125044
99Reticulocytopenia (HP:0001896)2.08841064
100Osteomalacia (HP:0002749)2.08106701
101Hepatocellular carcinoma (HP:0001402)2.08078414
102Adenoma sebaceum (HP:0009720)2.06422066
103Angiofibromas (HP:0010615)2.06422066
104Hyperglycinemia (HP:0002154)2.05738487
105Inflammation of the large intestine (HP:0002037)2.05047974
106Hypolipoproteinemia (HP:0010981)2.05005507
107IgA deficiency (HP:0002720)2.04937561
108Abnormality of the gallbladder (HP:0005264)2.04370467
109Abnormality of the lower motor neuron (HP:0002366)2.04155753
110Abnormal hemoglobin (HP:0011902)2.03611721
111Neoplasm of striated muscle (HP:0009728)2.02616137
112Hepatocellular necrosis (HP:0001404)1.99807814
113Increased intramyocellular lipid droplets (HP:0012240)1.97181650
114Cellulitis (HP:0100658)1.96811617
115Abnormal mitochondria in muscle tissue (HP:0008316)1.96574939
116Increased CSF lactate (HP:0002490)1.96500880
117Abnormality of the thoracic spine (HP:0100711)1.96105988
118Ileus (HP:0002595)1.95472611
119Missing ribs (HP:0000921)1.94777974
120Oral leukoplakia (HP:0002745)1.93282796
121Type I transferrin isoform profile (HP:0003642)1.92986833
122Abnormality of fatty-acid metabolism (HP:0004359)1.92850239
123Acute necrotizing encephalopathy (HP:0006965)1.90673506
124Delayed CNS myelination (HP:0002188)1.87249130
125Ependymoma (HP:0002888)1.86859781
126Muscle fiber inclusion bodies (HP:0100299)1.86805230
127Myoglobinuria (HP:0002913)1.86465767
128Viral hepatitis (HP:0006562)1.85485043
129Skin nodule (HP:0200036)1.85022541
130Secondary amenorrhea (HP:0000869)1.83117323
131Abnormality of nucleobase metabolism (HP:0010932)1.82585310
132Spastic diplegia (HP:0001264)1.82194406
133Abnormality of sulfur amino acid metabolism (HP:0004339)1.81053659
134Short middle phalanx of the 5th finger (HP:0004220)1.80799186
135Skin pits (HP:0100276)1.80707948
136Hypoparathyroidism (HP:0000829)1.80190895
137Neonatal hypoglycemia (HP:0001998)1.79404144
138Prominent nose (HP:0000448)1.76975106
139Autoimmune hemolytic anemia (HP:0001890)1.74856811
140Subacute progressive viral hepatitis (HP:0006572)1.72779498
141Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71092526
142Erythema (HP:0010783)1.71040018
143Abnormality of the tricuspid valve (HP:0001702)1.70139637
144Hamartoma (HP:0010566)1.69552764
145Supernumerary ribs (HP:0005815)1.68300887
146Visual hallucinations (HP:0002367)1.67818099
147Myopathic facies (HP:0002058)1.67458098
148Toxemia of pregnancy (HP:0100603)1.66974592
149Insidious onset (HP:0003587)1.66679295
150Termporal pattern (HP:0011008)1.66679295
151Rhabdomyolysis (HP:0003201)1.65725724
152Nemaline bodies (HP:0003798)1.64924072
153Birth length less than 3rd percentile (HP:0003561)1.64629790
154Abnormal ossification of hand bones (HP:0005921)1.64284069
155Centrally nucleated skeletal muscle fibers (HP:0003687)1.62691162
156Transposition of the great arteries (HP:0001669)1.61040056
157Abnormal connection of the cardiac segments (HP:0011545)1.61040056
158Abnormal ventriculo-arterial connection (HP:0011563)1.61040056
159Insomnia (HP:0100785)1.59222004
160Areflexia of lower limbs (HP:0002522)1.58564015
161Chromosomal breakage induced by crosslinking agents (HP:0003221)1.58360394
162Congenital malformation of the right heart (HP:0011723)1.56282592
163Double outlet right ventricle (HP:0001719)1.56282592
164Progressive external ophthalmoplegia (HP:0000590)1.56153449
165Papillary thyroid carcinoma (HP:0002895)1.55920072
166Abnormal hand bone ossification (HP:0010660)1.54445806
167Death in childhood (HP:0003819)1.53561652
168Milia (HP:0001056)1.50409769
169Abnormality of the phalanges of the hallux (HP:0010057)1.49759770
170Short phalanx of the thumb (HP:0009660)1.48513956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.50950725
2CDK124.44058552
3ERN14.43127689
4NME23.34119846
5GRK63.20859448
6EIF2AK13.11992628
7MAP3K102.90363454
8GRK52.76579178
9BCKDK2.74820487
10CDK192.39926268
11RPS6KA52.34826143
12TTK2.05173113
13TLK12.04590463
14PRPF4B2.00899035
15TRIB31.98269662
16CDC71.97041906
17STK101.87725710
18BUB11.87187547
19TGFBR21.74378701
20WEE11.65961784
21SCYL21.65828743
22CSF1R1.64578842
23OBSCN1.57319439
24DYRK31.55727030
25CDK71.54903908
26GRK11.54264462
27KDR1.47113836
28ICK1.45744956
29PKN21.44844695
30MAP3K111.43975282
31BLK1.40886578
32MATK1.37057603
33ADRBK21.36838084
34NEK21.35889131
35MOS1.34052933
36PBK1.31131877
37PIM21.31043560
38GRK71.29336473
39FLT31.29281880
40NEK11.26838220
41STK241.23742450
42ACVR1B1.22482753
43MAP3K11.21890293
44TESK21.21541195
45SMG11.21333307
46SGK31.21128429
47MAP3K51.19457595
48STK161.17162574
49CDK41.16343800
50PAK41.14356128
51PLK11.13990834
52BRAF1.13911777
53CAMK1D1.13832660
54ABL21.11837009
55SGK21.09482719
56VRK11.08397884
57DAPK31.07683611
58AURKA1.07511822
59TAF11.07026796
60TTN1.04900001
61MAPKAPK31.04628720
62PRKG21.04292186
63CHEK20.97212859
64STK40.95611956
65MAP3K80.94658938
66MAP2K30.93854829
67MAPK110.93035394
68SIK10.90839108
69AURKB0.89516552
70EEF2K0.88649962
71BMX0.88462624
72MAP2K40.87971653
73RPS6KB20.86439205
74RPS6KL10.81879460
75RPS6KC10.81879460
76IRAK30.80828031
77MAP2K60.79055022
78EPHA20.78179690
79HIPK20.77667665
80DYRK1B0.75638416
81AKT20.75563617
82LRRK20.74754256
83MAPK70.74105383
84MAP3K60.73255649
85BRSK10.72001959
86BRSK20.71621742
87MAP3K70.71085545
88MAPK120.69655486
89NME10.68748551
90TYRO30.67542649
91SGK2230.66695436
92SGK4940.66695436
93RPS6KA60.65370951
94TAOK10.64560350
95CAMK40.64226816
96ARAF0.63606129
97CAMK1G0.61143847
98TAOK30.60934075
99WNK10.60739531
100BTK0.59349749
101PIM10.58202121
102PIK3CG0.56840998
103CDK80.56174541
104CHEK10.55563138
105ERBB20.55104063
106TAOK20.51958592
107MAP3K20.51826047
108MAP3K120.51698916
109EIF2AK30.51660652
110JAK20.50742538
111MELK0.50721836
112MARK20.48984088
113ADRBK10.48531038
114SGK10.48147548
115RPS6KB10.46754633
116CCNB10.46184465
117RPS6KA40.45943306
118IRAK20.44499535
119MAP3K30.43280595
120EIF2AK20.42640550
121RET0.41839659
122MAP2K20.41257923
123PDPK10.40694092
124MAP3K90.40414835
125NTRK10.39928591
126PKN10.39258505
127PIK3CA0.39032877
128PRKCI0.38687077
129CDK20.38175993
130NEK90.37181358
131RPS6KA20.37139236
132MAPK40.36873407
133CSK0.36009234
134MAP4K10.35604992
135MTOR0.35576884
136ILK0.35432143
137MARK30.34526374
138PAK10.33482764
139CSNK2A10.33143198
140CSNK2A20.32826689
141PTK60.32191778
142CDK60.31911038
143TBK10.31378913
144TYK20.31352404
145ATM0.30922746
146PRKACG0.30521002
147PRKAA10.29266655
148ATR0.25260413
149PRKAA20.25227834

Predicted pathways (KEGG)

RankGene SetZ-score
1Alcoholism_Homo sapiens_hsa050345.11842188
2Ribosome_Homo sapiens_hsa030103.15590069
3Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.96280059
4Vitamin B6 metabolism_Homo sapiens_hsa007502.72780276
5Viral carcinogenesis_Homo sapiens_hsa052032.66928082
6DNA replication_Homo sapiens_hsa030302.55559004
7Sulfur relay system_Homo sapiens_hsa041222.53560949
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28767316
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28756958
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.24972003
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12312017
12Non-small cell lung cancer_Homo sapiens_hsa052232.10538001
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04464464
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96777661
15One carbon pool by folate_Homo sapiens_hsa006701.93662797
16Folate biosynthesis_Homo sapiens_hsa007901.91796807
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87546107
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85690397
19Selenocompound metabolism_Homo sapiens_hsa004501.84685050
20Tryptophan metabolism_Homo sapiens_hsa003801.81606257
21Fatty acid degradation_Homo sapiens_hsa000711.78862070
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77768608
23Carbon metabolism_Homo sapiens_hsa012001.69236974
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68433512
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.62704682
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57131439
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.54731945
28Mismatch repair_Homo sapiens_hsa034301.50428850
29Biosynthesis of amino acids_Homo sapiens_hsa012301.47992085
30Propanoate metabolism_Homo sapiens_hsa006401.46974258
31Pentose phosphate pathway_Homo sapiens_hsa000301.45655097
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45317261
33Arginine biosynthesis_Homo sapiens_hsa002201.40851772
34Parkinsons disease_Homo sapiens_hsa050121.40806092
35Chronic myeloid leukemia_Homo sapiens_hsa052201.40785737
36Fructose and mannose metabolism_Homo sapiens_hsa000511.40721399
37B cell receptor signaling pathway_Homo sapiens_hsa046621.40454109
38Pyrimidine metabolism_Homo sapiens_hsa002401.40418243
39Chemical carcinogenesis_Homo sapiens_hsa052041.37412198
40Pyruvate metabolism_Homo sapiens_hsa006201.35653376
41Peroxisome_Homo sapiens_hsa041461.33528669
42Pancreatic cancer_Homo sapiens_hsa052121.31314918
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29262615
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28973584
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28513512
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26661257
47Proteasome_Homo sapiens_hsa030501.26490744
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25893025
49Oxidative phosphorylation_Homo sapiens_hsa001901.25476992
50Complement and coagulation cascades_Homo sapiens_hsa046101.23853844
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23458382
52Galactose metabolism_Homo sapiens_hsa000521.23423641
53PPAR signaling pathway_Homo sapiens_hsa033201.16936060
54beta-Alanine metabolism_Homo sapiens_hsa004101.14794210
55mTOR signaling pathway_Homo sapiens_hsa041501.13829900
56Endometrial cancer_Homo sapiens_hsa052131.12965669
57Nitrogen metabolism_Homo sapiens_hsa009101.12737503
58Acute myeloid leukemia_Homo sapiens_hsa052211.10194914
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09258321
60Spliceosome_Homo sapiens_hsa030401.04605294
61Butanoate metabolism_Homo sapiens_hsa006501.04454258
62Glioma_Homo sapiens_hsa052141.04345231
63RNA transport_Homo sapiens_hsa030131.03472331
64Caffeine metabolism_Homo sapiens_hsa002321.03278834
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02229108
66RNA polymerase_Homo sapiens_hsa030201.02096525
67Inositol phosphate metabolism_Homo sapiens_hsa005621.01992259
68Small cell lung cancer_Homo sapiens_hsa052221.01704228
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01344583
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00536629
71AMPK signaling pathway_Homo sapiens_hsa041521.00399164
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99425249
73Base excision repair_Homo sapiens_hsa034100.99134805
74Homologous recombination_Homo sapiens_hsa034400.99118469
75Fatty acid metabolism_Homo sapiens_hsa012120.97891932
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.97321055
77Nucleotide excision repair_Homo sapiens_hsa034200.97290108
78Sulfur metabolism_Homo sapiens_hsa009200.95922957
79Glutathione metabolism_Homo sapiens_hsa004800.95388692
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94284174
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90714250
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88898203
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88196256
84Huntingtons disease_Homo sapiens_hsa050160.88192473
85Fat digestion and absorption_Homo sapiens_hsa049750.87192778
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85716090
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.85235289
88Linoleic acid metabolism_Homo sapiens_hsa005910.83557118
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.83329801
90VEGF signaling pathway_Homo sapiens_hsa043700.82324530
91Cell cycle_Homo sapiens_hsa041100.81972163
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81769337
93Retinol metabolism_Homo sapiens_hsa008300.81301113
94Renal cell carcinoma_Homo sapiens_hsa052110.81117654
95Starch and sucrose metabolism_Homo sapiens_hsa005000.79155114
96Metabolic pathways_Homo sapiens_hsa011000.78752596
97Systemic lupus erythematosus_Homo sapiens_hsa053220.78058275
98ErbB signaling pathway_Homo sapiens_hsa040120.77194579
99MicroRNAs in cancer_Homo sapiens_hsa052060.77147385
100ABC transporters_Homo sapiens_hsa020100.76428398
101FoxO signaling pathway_Homo sapiens_hsa040680.76122306
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73801177
103Bile secretion_Homo sapiens_hsa049760.73506668
104Tyrosine metabolism_Homo sapiens_hsa003500.72296721
105Arginine and proline metabolism_Homo sapiens_hsa003300.71403404
106HIF-1 signaling pathway_Homo sapiens_hsa040660.71318743
107Histidine metabolism_Homo sapiens_hsa003400.71278971
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70945255
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.69095854
110Basal cell carcinoma_Homo sapiens_hsa052170.69079255
111Thyroid cancer_Homo sapiens_hsa052160.67276551
112Phenylalanine metabolism_Homo sapiens_hsa003600.66925819
113Apoptosis_Homo sapiens_hsa042100.66764235
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.66762349
115Insulin signaling pathway_Homo sapiens_hsa049100.66280759
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65771692
117Alzheimers disease_Homo sapiens_hsa050100.65303860
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64992129
119HTLV-I infection_Homo sapiens_hsa051660.64778709
120Arachidonic acid metabolism_Homo sapiens_hsa005900.64041789
121Colorectal cancer_Homo sapiens_hsa052100.63270115
122Hedgehog signaling pathway_Homo sapiens_hsa043400.62660492
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62466370
124Bladder cancer_Homo sapiens_hsa052190.58728453
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58256649
126RNA degradation_Homo sapiens_hsa030180.57605027
127Prostate cancer_Homo sapiens_hsa052150.56027370
128Melanoma_Homo sapiens_hsa052180.55465477
129Renin-angiotensin system_Homo sapiens_hsa046140.51044284
130p53 signaling pathway_Homo sapiens_hsa041150.50474097
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.48137765
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47767209
133Prolactin signaling pathway_Homo sapiens_hsa049170.45942597
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45538481
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45447433
136N-Glycan biosynthesis_Homo sapiens_hsa005100.45178040
137Regulation of autophagy_Homo sapiens_hsa041400.43343296
138Lysine degradation_Homo sapiens_hsa003100.42620191
139Fanconi anemia pathway_Homo sapiens_hsa034600.41514526
140Fatty acid biosynthesis_Homo sapiens_hsa000610.41151783
141Protein export_Homo sapiens_hsa030600.39723825
142mRNA surveillance pathway_Homo sapiens_hsa030150.39436354
143Choline metabolism in cancer_Homo sapiens_hsa052310.36908838
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36280588
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36145863
146Purine metabolism_Homo sapiens_hsa002300.36086624
147Notch signaling pathway_Homo sapiens_hsa043300.34922129
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33630524
149Hepatitis B_Homo sapiens_hsa051610.33164960
150Malaria_Homo sapiens_hsa051440.32743974
151Insulin resistance_Homo sapiens_hsa049310.31850720
152Fatty acid elongation_Homo sapiens_hsa000620.31780712
153Glycerolipid metabolism_Homo sapiens_hsa005610.30797886
154Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29899492
155Cardiac muscle contraction_Homo sapiens_hsa042600.29713116
156Adipocytokine signaling pathway_Homo sapiens_hsa049200.27893337

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