GLRXP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.79092589
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.54634803
3cytidine catabolic process (GO:0006216)7.17214435
4cytidine deamination (GO:0009972)7.17214435
5cytidine metabolic process (GO:0046087)7.17214435
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.21622782
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.47564512
8actin nucleation (GO:0045010)5.06676981
9positive thymic T cell selection (GO:0045059)4.26829109
10cellular response to interleukin-15 (GO:0071350)4.14902009
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05938851
12positive T cell selection (GO:0043368)3.93438200
13response to interferon-beta (GO:0035456)3.81790389
14immunoglobulin mediated immune response (GO:0016064)3.74492524
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68732968
16ATP synthesis coupled proton transport (GO:0015986)3.68732968
17regulation of B cell receptor signaling pathway (GO:0050855)3.60516617
18negative regulation of viral genome replication (GO:0045071)3.56008242
19negative T cell selection (GO:0043383)3.51689846
20regulation of cellular amino acid metabolic process (GO:0006521)3.51475870
21positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.48718160
22positive regulation of natural killer cell mediated immunity (GO:0002717)3.46831430
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.46318207
24positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.45679349
25regulation of chronic inflammatory response (GO:0002676)3.44764433
26positive regulation of calcium-mediated signaling (GO:0050850)3.44188833
27negative regulation of T cell apoptotic process (GO:0070233)3.41268231
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38936545
29T cell costimulation (GO:0031295)3.36759865
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.35537794
31lymphocyte costimulation (GO:0031294)3.34339674
32kynurenine metabolic process (GO:0070189)3.31627775
33T cell receptor signaling pathway (GO:0050852)3.29597732
34antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.28576613
35response to interleukin-15 (GO:0070672)3.26871644
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25501953
37regulation of leukocyte mediated cytotoxicity (GO:0001910)3.21090883
38mast cell activation (GO:0045576)3.20013864
39tryptophan catabolic process (GO:0006569)3.19725106
40indole-containing compound catabolic process (GO:0042436)3.19725106
41indolalkylamine catabolic process (GO:0046218)3.19725106
42regulation of interleukin-8 secretion (GO:2000482)3.19323341
43proteasome assembly (GO:0043248)3.19081898
44positive regulation of interleukin-8 secretion (GO:2000484)3.18721192
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.15265976
46regulation of natural killer cell mediated immunity (GO:0002715)3.15265976
47protein neddylation (GO:0045116)3.14830985
48negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.14587789
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14531589
50intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14531589
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14140825
52signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14140825
53signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14140825
54pyrimidine nucleoside catabolic process (GO:0046135)3.13669989
55purine deoxyribonucleotide catabolic process (GO:0009155)3.13451128
56regulation of alpha-beta T cell proliferation (GO:0046640)3.12264664
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09793291
58antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.07683615
59B cell mediated immunity (GO:0019724)3.07526046
60positive regulation of defense response to virus by host (GO:0002230)3.07494843
61positive regulation of gamma-delta T cell activation (GO:0046645)3.06705447
62positive regulation of cell killing (GO:0031343)3.06382965
63regulation of T cell mediated cytotoxicity (GO:0001914)3.01622864
64positive regulation of prostaglandin secretion (GO:0032308)3.01152419
65negative thymic T cell selection (GO:0045060)3.00581008
66cytolysis (GO:0019835)2.98732023
67signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96411207
68signal transduction involved in DNA damage checkpoint (GO:0072422)2.96411207
69T cell migration (GO:0072678)2.95587201
70positive regulation of B cell differentiation (GO:0045579)2.93377825
71positive regulation of interleukin-1 beta secretion (GO:0050718)2.91621201
72signal transduction involved in cell cycle checkpoint (GO:0072395)2.91103870
73antigen receptor-mediated signaling pathway (GO:0050851)2.88989804
74positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87530682
75regulation of cell killing (GO:0031341)2.83573901
76metallo-sulfur cluster assembly (GO:0031163)2.82546352
77iron-sulfur cluster assembly (GO:0016226)2.82546352
78chaperone mediated protein folding requiring cofactor (GO:0051085)2.82215281
79negative regulation of interleukin-1 beta production (GO:0032691)2.80829117
80regulation of T cell tolerance induction (GO:0002664)2.80225872
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79085612
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77840220
83antigen processing and presentation via MHC class Ib (GO:0002475)2.77619698
84regulation of gamma-delta T cell differentiation (GO:0045586)2.77237174
85tryptophan metabolic process (GO:0006568)2.76460813
86positive regulation of interleukin-1 secretion (GO:0050716)2.76413855
87regulation of calcium-mediated signaling (GO:0050848)2.74970783
88regulation of regulatory T cell differentiation (GO:0045589)2.73947881
89negative regulation of ligase activity (GO:0051352)2.72904334
90negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72904334
91negative regulation of interleukin-1 production (GO:0032692)2.71553720
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69958984
93regulation of interleukin-1 beta secretion (GO:0050706)2.68374093
94negative regulation of lymphocyte apoptotic process (GO:0070229)2.67630801
95positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.66201752
96antigen processing and presentation of endogenous antigen (GO:0019883)2.62570254
97positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.62310428
98thymic T cell selection (GO:0045061)2.61254325
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60947651
100regulation of cellular amine metabolic process (GO:0033238)2.60910376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.19036377
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.79795851
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.38813247
4ELF1_17652178_ChIP-ChIP_JURKAT_Human4.18456149
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91409569
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.60580884
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.57321308
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.56998493
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.83451512
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74555460
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72070881
12MYB_26560356_Chip-Seq_TH2_Human2.51493727
13VDR_22108803_ChIP-Seq_LS180_Human2.46359887
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.31550090
15RUNX_20019798_ChIP-Seq_JUKART_Human2.29925792
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23575607
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22997759
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20330195
19VDR_23849224_ChIP-Seq_CD4+_Human2.08792402
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08630630
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04543511
22GATA3_26560356_Chip-Seq_TH2_Human2.03497577
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96509250
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.95955428
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92132064
26GATA3_27048872_Chip-Seq_THYMUS_Human1.76050576
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75595998
28IGF1R_20145208_ChIP-Seq_DFB_Human1.74873296
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74367090
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71147172
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67873762
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.63884275
33MYB_26560356_Chip-Seq_TH1_Human1.59658387
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54782710
35FOXP3_21729870_ChIP-Seq_TREG_Human1.49709227
36SPI1_23547873_ChIP-Seq_NB4_Human1.47500975
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46730441
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.40617497
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.39088117
40AR_20517297_ChIP-Seq_VCAP_Human1.37328371
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.37005187
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36006114
43ELK1_19687146_ChIP-ChIP_HELA_Human1.34028013
44ZNF274_21170338_ChIP-Seq_K562_Hela1.32564589
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31334322
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31291606
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31178940
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30532138
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30085583
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28640603
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.28640603
52TP53_22573176_ChIP-Seq_HFKS_Human1.27085817
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25725237
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25215981
55TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.24358428
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24144774
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23561980
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20552155
59GATA3_26560356_Chip-Seq_TH1_Human1.18577970
60GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.17638271
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16710949
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16202423
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.15863120
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12440089
65UTX_26944678_Chip-Seq_JUKART_Human1.11231895
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10397897
67ER_23166858_ChIP-Seq_MCF-7_Human1.06667195
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06198034
69CIITA_25753668_ChIP-Seq_RAJI_Human1.05860493
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05085363
71TAF2_19829295_ChIP-Seq_ESCs_Human1.04280558
72FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04248953
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02304556
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01806836
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.01469750
76MAF_26560356_Chip-Seq_TH1_Human1.01459025
77SOX2_19829295_ChIP-Seq_ESCs_Human1.01139900
78NANOG_19829295_ChIP-Seq_ESCs_Human1.01139900
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00715920
80MYC_18940864_ChIP-ChIP_HL60_Human1.00642405
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00303883
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99674298
83HTT_18923047_ChIP-ChIP_STHdh_Human0.99574067
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98999362
85SMAD_19615063_ChIP-ChIP_OVARY_Human0.98658910
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98638927
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98089363
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.97606047
89GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94447366
90EWS_26573619_Chip-Seq_HEK293_Human0.91214441
91CBP_20019798_ChIP-Seq_JUKART_Human0.89732685
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89732685
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89488870
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89006485
95BCL6_27268052_Chip-Seq_Bcells_Human0.88783982
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.88035283
97OCT4_20526341_ChIP-Seq_ESCs_Human0.87690760
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87537279
99ERG_20517297_ChIP-Seq_VCAP_Human0.87324388
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87133643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.83541752
2MP0001835_abnormal_antigen_presentation4.62947492
3MP0009785_altered_susceptibility_to3.48325955
4MP0002166_altered_tumor_susceptibility3.23383633
5MP0003950_abnormal_plasma_membrane2.99414289
6MP0005000_abnormal_immune_tolerance2.93919296
7MP0003763_abnormal_thymus_physiology2.68012042
8MP0000685_abnormal_immune_system2.64554692
9MP0001800_abnormal_humoral_immune2.59310605
10MP0003436_decreased_susceptibility_to2.54916612
11MP0002006_tumorigenesis2.48927228
12MP0008875_abnormal_xenobiotic_pharmacok2.48266788
13MP0003724_increased_susceptibility_to2.47004562
14MP0002148_abnormal_hypersensitivity_rea2.43393106
15MP0002723_abnormal_immune_serum2.41243148
16MP0002420_abnormal_adaptive_immunity2.38263385
17MP0001819_abnormal_immune_cell2.37921636
18MP0002452_abnormal_antigen_presenting2.23847683
19MP0002138_abnormal_hepatobiliary_system2.23312607
20MP0009333_abnormal_splenocyte_physiolog2.09716256
21MP0005025_abnormal_response_to2.04993784
22MP0006072_abnormal_retinal_apoptosis2.04037561
23MP0001790_abnormal_immune_system2.03000241
24MP0005387_immune_system_phenotype2.03000241
25MP0003866_abnormal_defecation2.01268789
26MP0006082_CNS_inflammation1.93581852
27MP0000372_irregular_coat_pigmentation1.88384229
28MP0002419_abnormal_innate_immunity1.83537853
29MP0003195_calcinosis1.81397906
30MP0009764_decreased_sensitivity_to1.78927055
31MP0010155_abnormal_intestine_physiology1.78692457
32MP0000716_abnormal_immune_system1.72788874
33MP0005084_abnormal_gallbladder_morpholo1.72535239
34MP0008877_abnormal_DNA_methylation1.70659335
35MP0002398_abnormal_bone_marrow1.69632021
36MP0004147_increased_porphyrin_level1.66223165
37MP0001845_abnormal_inflammatory_respons1.54617988
38MP0000689_abnormal_spleen_morphology1.52109101
39MP0002933_joint_inflammation1.47211794
40MP0002722_abnormal_immune_system1.43705163
41MP0002405_respiratory_system_inflammati1.41183684
42MP0000703_abnormal_thymus_morphology1.39764996
43MP0001533_abnormal_skeleton_physiology1.37408930
44MP0003011_delayed_dark_adaptation1.34742696
45MP0002429_abnormal_blood_cell1.32687508
46MP0002102_abnormal_ear_morphology1.32465939
47MP0001919_abnormal_reproductive_system1.31354425
48MP0001968_abnormal_touch/_nociception1.28082533
49MP0002254_reproductive_system_inflammat1.27881870
50MP0004947_skin_inflammation1.26421174
51MP0006054_spinal_hemorrhage1.26111907
52MP0004145_abnormal_muscle_electrophysio1.23154210
53MP0001853_heart_inflammation1.21260572
54MP0003448_altered_tumor_morphology1.16860002
55MP0008872_abnormal_physiological_respon1.16809200
56MP0005645_abnormal_hypothalamus_physiol1.14991894
57MP0005075_abnormal_melanosome_morpholog1.14276560
58MP0001873_stomach_inflammation1.12739002
59MP0002736_abnormal_nociception_after1.12536130
60MP0003252_abnormal_bile_duct1.11086616
61MP0008058_abnormal_DNA_repair1.10900981
62MP0008469_abnormal_protein_level1.03403950
63MP0005389_reproductive_system_phenotype1.02297709
64MP0009763_increased_sensitivity_to1.00364732
65MP0005253_abnormal_eye_physiology0.96991359
66MP0005551_abnormal_eye_electrophysiolog0.96144153
67MP0001905_abnormal_dopamine_level0.92541005
68MP0002009_preneoplasia0.92522385
69MP0005464_abnormal_platelet_physiology0.91411849
70MP0003806_abnormal_nucleotide_metabolis0.88400128
71MP0005166_decreased_susceptibility_to0.87639902
72MP0003137_abnormal_impulse_conducting0.82851124
73MP0005165_increased_susceptibility_to0.82226177
74MP0002876_abnormal_thyroid_physiology0.82223928
75MP0005410_abnormal_fertilization0.79648389
76MP0003075_altered_response_to0.79450996
77MP0003786_premature_aging0.75632265
78MP0002019_abnormal_tumor_incidence0.75449252
79MP0005646_abnormal_pituitary_gland0.74253434
80MP0005647_abnormal_sex_gland0.73332959
81MP0000465_gastrointestinal_hemorrhage0.71346678
82MP0000858_altered_metastatic_potential0.70827772
83MP0005636_abnormal_mineral_homeostasis0.70592789
84MP0005584_abnormal_enzyme/coenzyme_acti0.69282667
85MP0001542_abnormal_bone_strength0.69157630
86MP0001986_abnormal_taste_sensitivity0.67949065
87MP0004885_abnormal_endolymph0.64797276
88MP0003878_abnormal_ear_physiology0.63105951
89MP0005377_hearing/vestibular/ear_phenot0.63105951
90MP0002837_dystrophic_cardiac_calcinosis0.62689448
91MP0005390_skeleton_phenotype0.62611121
92MP0006036_abnormal_mitochondrial_physio0.61276607
93MP0009643_abnormal_urine_homeostasis0.59276727
94MP0001501_abnormal_sleep_pattern0.58905849
95MP0002693_abnormal_pancreas_physiology0.55773670
96MP0001119_abnormal_female_reproductive0.52737734
97MP0001970_abnormal_pain_threshold0.51345093
98MP0008873_increased_physiological_sensi0.50853218
99MP0002136_abnormal_kidney_physiology0.48832797
100MP0002139_abnormal_hepatobiliary_system0.48488653

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.97135642
2T lymphocytopenia (HP:0005403)4.48863615
3IgG deficiency (HP:0004315)4.17416201
4Abnormality of T cell number (HP:0011839)4.12623768
5Autoimmune hemolytic anemia (HP:0001890)3.92977986
6Acute necrotizing encephalopathy (HP:0006965)3.70116004
7Mitochondrial inheritance (HP:0001427)3.61189154
8Stomatitis (HP:0010280)3.58922143
9Abnormal mitochondria in muscle tissue (HP:0008316)3.43705868
10Hypoproteinemia (HP:0003075)3.41688007
11Abnormality of the prostate (HP:0008775)3.41415586
12Abnormality of T cells (HP:0002843)3.38081085
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.34581676
14Autoimmune thrombocytopenia (HP:0001973)3.22666046
15Hepatocellular necrosis (HP:0001404)3.20017220
16Severe combined immunodeficiency (HP:0004430)3.15281609
17Progressive macrocephaly (HP:0004481)3.12794947
18Increased CSF lactate (HP:0002490)3.07895525
19Aplastic anemia (HP:0001915)2.99000192
20Abnormality of B cell number (HP:0010975)2.93550892
21Acute encephalopathy (HP:0006846)2.85743071
22Cerebral palsy (HP:0100021)2.85173582
23Prostate neoplasm (HP:0100787)2.77255465
24Abolished electroretinogram (ERG) (HP:0000550)2.76386744
25Hepatic necrosis (HP:0002605)2.74770119
26Congenital stationary night blindness (HP:0007642)2.73086041
27Increased IgM level (HP:0003496)2.72454404
28Congenital, generalized hypertrichosis (HP:0004540)2.70879536
29Thyroiditis (HP:0100646)2.69983282
30B lymphocytopenia (HP:0010976)2.68428745
31Myositis (HP:0100614)2.58736687
32Cerebral edema (HP:0002181)2.58000357
33Pustule (HP:0200039)2.56700174
34Decreased central vision (HP:0007663)2.55993256
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55780933
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55780933
37Abnormality of eosinophils (HP:0001879)2.54545614
38Abnormal rod and cone electroretinograms (HP:0008323)2.53913943
39Testicular atrophy (HP:0000029)2.51757777
40Recurrent bronchitis (HP:0002837)2.50444623
41Combined immunodeficiency (HP:0005387)2.49646061
42Chronic diarrhea (HP:0002028)2.47892659
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.45786654
44Gastrointestinal infarctions (HP:0005244)2.42847953
45Fibular aplasia (HP:0002990)2.42749037
46Hemoptysis (HP:0002105)2.42504790
47Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.40025250
48Exertional dyspnea (HP:0002875)2.38197640
49Increased hepatocellular lipid droplets (HP:0006565)2.37124024
50Recurrent viral infections (HP:0004429)2.33134915
51Eosinophilia (HP:0001880)2.32135980
52Meningitis (HP:0001287)2.30147003
53Vasculitis (HP:0002633)2.29066547
543-Methylglutaconic aciduria (HP:0003535)2.25696983
55Attenuation of retinal blood vessels (HP:0007843)2.25672101
56Renal Fanconi syndrome (HP:0001994)2.24243080
57Visual hallucinations (HP:0002367)2.24042014
58Obstructive lung disease (HP:0006536)2.23796659
59Chronic obstructive pulmonary disease (HP:0006510)2.23796659
60Leukocytosis (HP:0001974)2.21996385
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20538160
62Abnormality of T cell physiology (HP:0011840)2.19921272
63Recurrent cutaneous fungal infections (HP:0011370)2.19244943
64Chronic mucocutaneous candidiasis (HP:0002728)2.19244943
65Abnormality of the phalanges of the 5th finger (HP:0004213)2.15503810
66Pulmonary infiltrates (HP:0002113)2.15392959
67Lymphopenia (HP:0001888)2.13750104
68Abnormal albumin level (HP:0012116)2.13442598
69Hypoalbuminemia (HP:0003073)2.13442598
70Recurrent fungal infections (HP:0002841)2.12616847
71Tetraparesis (HP:0002273)2.10089613
72Increased intramyocellular lipid droplets (HP:0012240)2.09292581
73Lactic acidosis (HP:0003128)2.09100753
74Renal cortical cysts (HP:0000803)2.07173292
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04895707
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02195268
77Lipid accumulation in hepatocytes (HP:0006561)2.01603585
78Parakeratosis (HP:0001036)1.98283567
79Increased serum lactate (HP:0002151)1.96578820
80Optic disc pallor (HP:0000543)1.95773681
81Abnormality of the proximal phalanges of the hand (HP:0009834)1.93843912
82Chronic sinusitis (HP:0011109)1.92689149
83Constricted visual fields (HP:0001133)1.91391054
84Abnormality of the pleura (HP:0002103)1.90911979
85Panhypogammaglobulinemia (HP:0003139)1.90675637
86Short tibia (HP:0005736)1.90507293
87Encephalitis (HP:0002383)1.90006622
88Respiratory failure (HP:0002878)1.89332900
89Gangrene (HP:0100758)1.88136334
90Abnormality of cells of the lymphoid lineage (HP:0012140)1.88084859
91Generalized aminoaciduria (HP:0002909)1.86881327
92Facial diplegia (HP:0001349)1.86761899
93Granulocytopenia (HP:0001913)1.86623837
94Lymphoma (HP:0002665)1.86311927
95Hypothermia (HP:0002045)1.84061665
96Pancreatic cysts (HP:0001737)1.83308097
97Keratoconjunctivitis (HP:0001096)1.81182358
98Bronchitis (HP:0012387)1.80605458
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.80319244
100Retrobulbar optic neuritis (HP:0100654)1.79020813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.27144241
2TESK23.55162195
3TXK3.36193611
4MAP4K13.02788524
5MAP3K122.84019612
6GRK62.72285120
7BCKDK2.39746227
8EIF2AK32.24056126
9TLK12.23989788
10TAOK32.22061559
11MAP4K22.15741804
12BMPR22.14501960
13CDK192.05332620
14ZAK1.95738350
15MST41.87930789
16INSRR1.74867181
17FES1.72707529
18MYLK1.68967223
19FRK1.67366473
20SYK1.65409214
21KIT1.64269102
22TBK11.63320986
23ADRBK21.57130550
24ITK1.56816304
25SCYL21.49745609
26GRK11.48740940
27IKBKB1.44321095
28MAPKAPK31.41855569
29NUAK11.41757144
30BTK1.41658394
31MATK1.40785885
32MAP3K141.39233137
33ZAP701.32245706
34TEC1.32244531
35PASK1.29387930
36LIMK11.26711625
37EIF2AK11.25688991
38LCK1.19921879
39MUSK1.15955595
40DAPK11.13550431
41ERBB31.07987514
42IKBKE1.07572095
43LYN1.07546185
44VRK21.04777044
45NEK11.04308650
46TESK11.04300334
47VRK11.04105701
48CAMKK21.02424011
49TIE11.02248135
50PRKCQ0.93617580
51FLT30.92214006
52BMPR1B0.91383758
53CSF1R0.85200490
54BUB10.83051765
55EIF2AK20.82078312
56OXSR10.80821151
57JAK30.79567166
58CAMKK10.78555152
59TRIM280.77454545
60IGF1R0.75076502
61JAK10.72303659
62NTRK10.69332885
63GRK70.68830643
64MAP3K110.66217548
65WNK30.65518502
66PIK3CA0.64345604
67PLK20.62480544
68CSNK1G30.60686030
69HCK0.56899450
70CSK0.56623894
71CSNK1A1L0.55383531
72MAP2K20.55278833
73ACVR1B0.54307478
74ROCK10.53319255
75RPS6KA40.49345554
76GRK50.46729368
77ADRBK10.46486854
78PAK10.46483787
79MAP2K70.46172604
80MAP3K40.42884150
81ABL10.42727857
82TRPM70.42325008
83TNK20.41083638
84MAPK130.38826532
85PIM10.38007157
86OBSCN0.37749681
87ILK0.37489860
88PRKCA0.37445997
89RPS6KA50.35797670
90INSR0.34587559
91STK160.33335036
92CSNK1G10.33317235
93BLK0.33093494
94EGFR0.32166630
95FYN0.32126236
96RIPK40.31501506
97PHKG10.31097153
98PHKG20.31097153
99MAP3K50.31008396
100TGFBR10.27994977

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.30238619
2Caffeine metabolism_Homo sapiens_hsa002324.10299630
3Graft-versus-host disease_Homo sapiens_hsa053324.07717081
4Allograft rejection_Homo sapiens_hsa053303.86231482
5Asthma_Homo sapiens_hsa053103.73864115
6Autoimmune thyroid disease_Homo sapiens_hsa053203.72459402
7Primary immunodeficiency_Homo sapiens_hsa053403.41756779
8Type I diabetes mellitus_Homo sapiens_hsa049403.14497273
9Intestinal immune network for IgA production_Homo sapiens_hsa046723.10519627
10Antigen processing and presentation_Homo sapiens_hsa046123.09021288
11Oxidative phosphorylation_Homo sapiens_hsa001902.48174850
12Hematopoietic cell lineage_Homo sapiens_hsa046402.08379525
13Rheumatoid arthritis_Homo sapiens_hsa053232.01817833
14Parkinsons disease_Homo sapiens_hsa050121.96493552
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93043023
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89262233
17Viral myocarditis_Homo sapiens_hsa054161.85053405
18Protein export_Homo sapiens_hsa030601.65991199
19Staphylococcus aureus infection_Homo sapiens_hsa051501.63538351
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63410882
21RNA polymerase_Homo sapiens_hsa030201.46062294
22Alzheimers disease_Homo sapiens_hsa050101.31298444
23Leishmaniasis_Homo sapiens_hsa051401.30311945
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25779855
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19060392
26T cell receptor signaling pathway_Homo sapiens_hsa046601.14925296
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05559616
28Phototransduction_Homo sapiens_hsa047441.03490036
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.02014824
30Huntingtons disease_Homo sapiens_hsa050161.01769922
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01312985
32Sulfur metabolism_Homo sapiens_hsa009200.97761392
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95884279
34Ribosome_Homo sapiens_hsa030100.91675970
35Herpes simplex infection_Homo sapiens_hsa051680.88917380
36Drug metabolism - other enzymes_Homo sapiens_hsa009830.88333891
37SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87864877
38Cardiac muscle contraction_Homo sapiens_hsa042600.87740694
39Measles_Homo sapiens_hsa051620.85703053
40Systemic lupus erythematosus_Homo sapiens_hsa053220.83933602
41RNA degradation_Homo sapiens_hsa030180.82532658
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77808036
43Shigellosis_Homo sapiens_hsa051310.77042108
44Malaria_Homo sapiens_hsa051440.75008428
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72511989
46Nitrogen metabolism_Homo sapiens_hsa009100.71167385
47Collecting duct acid secretion_Homo sapiens_hsa049660.69790348
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68823108
49Chemical carcinogenesis_Homo sapiens_hsa052040.68665859
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62534631
51Pyrimidine metabolism_Homo sapiens_hsa002400.62085980
52Tryptophan metabolism_Homo sapiens_hsa003800.61663573
53Peroxisome_Homo sapiens_hsa041460.58761610
54DNA replication_Homo sapiens_hsa030300.57470741
55Pertussis_Homo sapiens_hsa051330.56023909
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.55867083
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55489486
58Purine metabolism_Homo sapiens_hsa002300.52593883
59Legionellosis_Homo sapiens_hsa051340.52459403
60Epstein-Barr virus infection_Homo sapiens_hsa051690.51403312
61Salmonella infection_Homo sapiens_hsa051320.51373024
62Linoleic acid metabolism_Homo sapiens_hsa005910.50685351
63Olfactory transduction_Homo sapiens_hsa047400.49311858
64Mismatch repair_Homo sapiens_hsa034300.49152374
65Influenza A_Homo sapiens_hsa051640.49128116
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47782721
67Tuberculosis_Homo sapiens_hsa051520.47420055
68Regulation of autophagy_Homo sapiens_hsa041400.45562955
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45196874
70Toxoplasmosis_Homo sapiens_hsa051450.44320610
71Fanconi anemia pathway_Homo sapiens_hsa034600.43810261
72Phagosome_Homo sapiens_hsa041450.43750998
73Basal transcription factors_Homo sapiens_hsa030220.43024579
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.42932641
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42751246
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41522143
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38336422
78Spliceosome_Homo sapiens_hsa030400.38103262
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.37958527
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34811364
81Homologous recombination_Homo sapiens_hsa034400.33569251
82Retinol metabolism_Homo sapiens_hsa008300.33301814
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31004070
84Nucleotide excision repair_Homo sapiens_hsa034200.30921732
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30177607
86HTLV-I infection_Homo sapiens_hsa051660.29994850
87Arachidonic acid metabolism_Homo sapiens_hsa005900.27964683
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27894914
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23603806
90Metabolic pathways_Homo sapiens_hsa011000.21521241
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21160631
92Taste transduction_Homo sapiens_hsa047420.21112922
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19721583
94Propanoate metabolism_Homo sapiens_hsa006400.18434610
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17565920
96TNF signaling pathway_Homo sapiens_hsa046680.14342992
97N-Glycan biosynthesis_Homo sapiens_hsa005100.13251432
98Osteoclast differentiation_Homo sapiens_hsa043800.11764407
99Base excision repair_Homo sapiens_hsa034100.11278835
100Fat digestion and absorption_Homo sapiens_hsa049750.10806229

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