GLS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.81980122
2synaptic vesicle maturation (GO:0016188)5.39387136
3locomotory exploration behavior (GO:0035641)5.11700262
4regulation of extracellular matrix disassembly (GO:0010715)5.08224828
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.87611495
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.82259096
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81085991
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.70291853
9regulation of synaptic vesicle exocytosis (GO:2000300)4.50813859
10synaptic vesicle exocytosis (GO:0016079)4.34256972
11vocalization behavior (GO:0071625)4.31580240
12cellular potassium ion homeostasis (GO:0030007)4.24677304
13* glutamate secretion (GO:0014047)4.19086115
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.12628310
15glutamate receptor signaling pathway (GO:0007215)4.07617953
16regulation of glutamate receptor signaling pathway (GO:1900449)3.97423360
17regulation of synaptic vesicle transport (GO:1902803)3.94598763
18synaptic transmission, glutamatergic (GO:0035249)3.92061200
19protein localization to synapse (GO:0035418)3.79516259
20exploration behavior (GO:0035640)3.73256996
21regulation of long-term neuronal synaptic plasticity (GO:0048169)3.71835496
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.71449777
23sodium ion export (GO:0071436)3.70962075
24regulation of transforming growth factor beta1 production (GO:0032908)3.69250591
25regulation of neuronal synaptic plasticity (GO:0048168)3.62509534
26neuron-neuron synaptic transmission (GO:0007270)3.60706890
27cerebellar Purkinje cell differentiation (GO:0021702)3.60625032
28neuronal action potential propagation (GO:0019227)3.52937491
29* neurotransmitter secretion (GO:0007269)3.51440498
30proline transport (GO:0015824)3.48649957
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48474787
32detection of calcium ion (GO:0005513)3.47909942
33regulation of Rac protein signal transduction (GO:0035020)3.47786181
34layer formation in cerebral cortex (GO:0021819)3.45480841
35cell adhesion mediated by integrin (GO:0033627)3.45428386
36long-term memory (GO:0007616)3.44455966
37peptide hormone processing (GO:0016486)3.38993784
38regulation of postsynaptic membrane potential (GO:0060078)3.36174161
39inositol phosphate-mediated signaling (GO:0048016)3.36021561
40positive regulation of gluconeogenesis (GO:0045722)3.30821367
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30754163
42synaptic vesicle endocytosis (GO:0048488)3.27187385
43dendritic spine morphogenesis (GO:0060997)3.27164905
44sequestering of extracellular ligand from receptor (GO:0035581)3.23300516
45neuron cell-cell adhesion (GO:0007158)3.21719715
46regulation of synapse structural plasticity (GO:0051823)3.20558114
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20295089
48long-term synaptic potentiation (GO:0060291)3.17679658
49vesicle transport along microtubule (GO:0047496)3.16131593
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.13940659
51regulation of clathrin-mediated endocytosis (GO:2000369)3.12397152
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12026880
53innervation (GO:0060384)3.09897452
54regulation of synaptic plasticity (GO:0048167)3.07912758
55regulation of neurotransmitter secretion (GO:0046928)3.07569168
56neuron recognition (GO:0008038)3.07494116
57regulation of dendritic spine morphogenesis (GO:0061001)3.06840476
58activation of protein kinase A activity (GO:0034199)3.06194516
59regulation of vesicle fusion (GO:0031338)3.06025255
60positive regulation of membrane potential (GO:0045838)3.05881332
61negative regulation of execution phase of apoptosis (GO:1900118)3.01883902
62chemosensory behavior (GO:0007635)3.01539119
63positive regulation of neurotransmitter secretion (GO:0001956)2.99362832
64membrane depolarization during action potential (GO:0086010)2.97171144
65regulation of ARF protein signal transduction (GO:0032012)2.96369968
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96133450
67insulin secretion (GO:0030073)2.94920598
68positive regulation of synapse maturation (GO:0090129)2.94202739
69cell communication by electrical coupling (GO:0010644)2.92211619
70regulation of synaptic transmission, glutamatergic (GO:0051966)2.91432395
71dendrite morphogenesis (GO:0048813)2.89978343
72negative regulation of complement activation (GO:0045916)2.89618228
73* neurotransmitter transport (GO:0006836)2.89268343
74response to histamine (GO:0034776)2.86985684
75neurotransmitter-gated ion channel clustering (GO:0072578)2.86554254
76behavioral fear response (GO:0001662)2.86462666
77behavioral defense response (GO:0002209)2.86462666
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86009533
79membrane depolarization (GO:0051899)2.85436026
80neuromuscular process controlling balance (GO:0050885)2.84859366
81cellular response to ethanol (GO:0071361)2.84623600
82lipid translocation (GO:0034204)2.84021937
83phospholipid translocation (GO:0045332)2.84021937
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83814537
85nerve growth factor signaling pathway (GO:0038180)2.83787881
86negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83351173
87Golgi to endosome transport (GO:0006895)2.83300220
88macroautophagy (GO:0016236)2.81120325
89positive regulation of dendritic spine morphogenesis (GO:0061003)2.80746796
90positive regulation of neurotransmitter transport (GO:0051590)2.79548122
91regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.79539003
92COPII vesicle coating (GO:0048208)2.78041249
93negative regulation of dendrite morphogenesis (GO:0050774)2.77252447
94positive regulation of vesicle fusion (GO:0031340)2.76056871
95axonal fasciculation (GO:0007413)2.74722428
96sphingomyelin metabolic process (GO:0006684)2.73480976
97regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.72607554
98regulation of dendritic spine development (GO:0060998)2.72255287
99regulation of voltage-gated calcium channel activity (GO:1901385)2.71994280
100regulation of neurotransmitter transport (GO:0051588)2.70582611
101cellular response to vitamin D (GO:0071305)2.70221514
102clathrin coat assembly (GO:0048268)2.69956144
103establishment of nucleus localization (GO:0040023)2.69792773
104gamma-aminobutyric acid transport (GO:0015812)2.68873394
105fear response (GO:0042596)2.68593568
106regulation of execution phase of apoptosis (GO:1900117)2.67637065
107positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.66127334
108positive regulation of transforming growth factor beta production (GO:0071636)2.66016481
109potassium ion import (GO:0010107)2.65344959
110cellular zinc ion homeostasis (GO:0006882)2.65058604
111membrane hyperpolarization (GO:0060081)2.64186942
112hemidesmosome assembly (GO:0031581)2.63590475
113response to pheromone (GO:0019236)2.63310405
114early endosome to late endosome transport (GO:0045022)2.63022624
115phospholipid dephosphorylation (GO:0046839)2.62595335
116G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.62314102
117positive regulation of Rap GTPase activity (GO:0032854)2.62126000
118cerebellar granule cell differentiation (GO:0021707)2.59538050
119positive regulation of fibroblast migration (GO:0010763)2.59100449
120dendritic spine organization (GO:0097061)2.59099269
121sphingosine metabolic process (GO:0006670)2.58786315
122actin filament depolymerization (GO:0030042)2.56475463
123positive regulation of synaptic transmission (GO:0050806)2.55148821
124negative regulation of cell killing (GO:0031342)2.55110351
125negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.55110351
126organelle transport along microtubule (GO:0072384)2.54439306
127protein localization to endosome (GO:0036010)2.53857432
128long term synaptic depression (GO:0060292)2.53454662
129positive regulation of synaptic transmission, GABAergic (GO:0032230)2.53337096
130learning (GO:0007612)2.52332330
131negative regulation of hormone biosynthetic process (GO:0032353)2.51950350
132synapse assembly (GO:0007416)2.51766016
133positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51365678
134potassium ion homeostasis (GO:0055075)2.51337828
135auditory receptor cell differentiation (GO:0042491)2.51257941
136prepulse inhibition (GO:0060134)2.51062732
137phosphatidylinositol dephosphorylation (GO:0046856)2.49997413
138endocytic recycling (GO:0032456)2.49623636
139positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.48866814
140negative regulation of protein activation cascade (GO:2000258)2.47420805
141regulation of type B pancreatic cell apoptotic process (GO:2000674)2.46336216
142myelin maintenance (GO:0043217)2.45441935
143cytoskeletal anchoring at plasma membrane (GO:0007016)2.43178860
144smooth muscle tissue development (GO:0048745)2.42695063
145positive regulation of macroautophagy (GO:0016239)2.42149304
146peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.36961955
147negative regulation of hormone metabolic process (GO:0032351)2.32757236
148cellular response to vitamin (GO:0071295)2.32386917
149positive regulation of calcium ion import (GO:0090280)2.26953039
150positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.25890746
151negative regulation of cytosolic calcium ion concentration (GO:0051481)2.25721127
152regulation of transforming growth factor beta production (GO:0071634)2.25435577
153platelet-derived growth factor receptor signaling pathway (GO:0048008)2.24962008
154relaxation of cardiac muscle (GO:0055119)2.23569154
155negative regulation of neurotransmitter secretion (GO:0046929)2.22783746
156import into cell (GO:0098657)2.22762687
157iron ion import (GO:0097286)2.22460696
158regulation of glucocorticoid metabolic process (GO:0031943)2.21780862
159zinc ion homeostasis (GO:0055069)2.21368118
160regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.20456775
161regulation of Rap GTPase activity (GO:0032317)2.19446298
162positive regulation of nitric-oxide synthase activity (GO:0051000)2.19064096
163regulation of extracellular matrix organization (GO:1903053)2.18713541
164skin morphogenesis (GO:0043589)2.14484986
165positive regulation of histone H3-K4 methylation (GO:0051571)2.13537606
166interleukin-6-mediated signaling pathway (GO:0070102)2.13229710
167Rap protein signal transduction (GO:0032486)2.12263946
168negative regulation of humoral immune response (GO:0002921)2.08295379
169positive regulation of endothelial cell apoptotic process (GO:2000353)2.08025077
170diol metabolic process (GO:0034311)2.07380384
171positive regulation of insulin secretion (GO:0032024)2.07308678
172negative regulation of fatty acid transport (GO:2000192)2.06447754
173response to parathyroid hormone (GO:0071107)2.06104705
174nodal signaling pathway (GO:0038092)2.05475112
175regulation of beta-amyloid formation (GO:1902003)2.05006788
176regulation of transforming growth factor beta2 production (GO:0032909)2.03612666
177response to lead ion (GO:0010288)2.03390780
178mRNA modification (GO:0016556)2.02773133
179inositol metabolic process (GO:0006020)2.02154159
180extracellular regulation of signal transduction (GO:1900115)2.01595101
181extracellular negative regulation of signal transduction (GO:1900116)2.01595101
182glycerophospholipid catabolic process (GO:0046475)2.00826734
183glomerular visceral epithelial cell development (GO:0072015)2.00357407
184regulation of protein glycosylation (GO:0060049)1.97598733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.85478764
2EZH2_22144423_ChIP-Seq_EOC_Human4.44554665
3GBX2_23144817_ChIP-Seq_PC3_Human3.54155613
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.63911557
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53096817
6DROSHA_22980978_ChIP-Seq_HELA_Human2.43354069
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40766713
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37579121
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.23057516
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16416318
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15798246
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13326123
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13326123
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09178497
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03835011
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02486920
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02151280
18REST_21632747_ChIP-Seq_MESCs_Mouse1.99851223
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98156323
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.95270820
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93973068
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89606265
23GATA1_22025678_ChIP-Seq_K562_Human1.81201482
24AR_21572438_ChIP-Seq_LNCaP_Human1.79503670
25* SMAD4_21799915_ChIP-Seq_A2780_Human1.78796742
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.73969666
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72319439
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.70412423
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69503516
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.68948503
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.68503614
32* FLI1_27457419_Chip-Seq_LIVER_Mouse1.68136097
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.65134881
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63252242
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63095517
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62816873
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.62451663
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61648240
39TP53_16413492_ChIP-PET_HCT116_Human1.61422770
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60697913
41CJUN_26792858_Chip-Seq_BT549_Human1.57164067
42* BRD4_25478319_ChIP-Seq_HGPS_Human1.56397211
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54893441
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54756262
45* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52251741
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.52016982
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50555040
48* EP300_21415370_ChIP-Seq_HL-1_Mouse1.49931076
49TAF15_26573619_Chip-Seq_HEK293_Human1.48974432
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.48415638
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43921017
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.43517797
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42758544
54P300_19829295_ChIP-Seq_ESCs_Human1.41217300
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40081156
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39552380
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38704988
58ZNF274_21170338_ChIP-Seq_K562_Hela1.37100417
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37062040
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.36701440
61* STAT3_23295773_ChIP-Seq_U87_Human1.36369467
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35394798
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32884583
64AR_25329375_ChIP-Seq_VCAP_Human1.32621854
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32362245
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31848757
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31266580
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30687410
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29763292
70* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28473729
71* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28186585
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27377397
73* SMAD3_21741376_ChIP-Seq_EPCs_Human1.27300117
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27079886
75* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25586622
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.25121032
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23684888
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.23597786
79AR_19668381_ChIP-Seq_PC3_Human1.23073297
80AHR_22903824_ChIP-Seq_MCF-7_Human1.22447918
81FUS_26573619_Chip-Seq_HEK293_Human1.22428619
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20708937
83IGF1R_20145208_ChIP-Seq_DFB_Human1.20227868
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19438324
85FOXA2_19822575_ChIP-Seq_HepG2_Human1.19160941
86* TCF4_23295773_ChIP-Seq_U87_Human1.18693709
87RXR_22108803_ChIP-Seq_LS180_Human1.18323643
88* SOX2_20726797_ChIP-Seq_SW620_Human1.17775871
89* CMYC_18555785_Chip-Seq_ESCs_Mouse1.17669010
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17295225
91* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17242408
92TP53_18474530_ChIP-ChIP_U2OS_Human1.16671149
93TP63_23658742_ChIP-Seq_EP156T_Human1.15861295
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15828176
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15749911
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15626451
97* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15213254
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.14454776
99* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13075702
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12814485
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.12701905
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12180090
103* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12035384
104* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12035384
105* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11049238
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10315953
107* SOX2_18555785_Chip-Seq_ESCs_Mouse1.09965026
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09667191
109FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08559353
110* P53_22387025_ChIP-Seq_ESCs_Mouse1.08525714
111* EZH2_27294783_Chip-Seq_NPCs_Mouse1.08060352
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07482619
113* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07424437
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06322524
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05682480
116IRF8_27001747_Chip-Seq_BMDM_Mouse1.05206590
117PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04309780
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03600561
119* PRDM14_20953172_ChIP-Seq_ESCs_Human1.03340118
120KDM2B_26808549_Chip-Seq_REH_Human1.02769377
121* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02566091
122* NMYC_18555785_Chip-Seq_ESCs_Mouse1.02125541
123KDM2B_26808549_Chip-Seq_K562_Human1.01884145
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.01875456
125* NFE2_27457419_Chip-Seq_LIVER_Mouse1.00772581
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00756188
127* NANOG_18555785_Chip-Seq_ESCs_Mouse1.00709399
128* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99690305
129* STAT3_18555785_Chip-Seq_ESCs_Mouse0.98651712
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.98213328
131* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98060648
132CDX2_22108803_ChIP-Seq_LS180_Human0.97815224
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97474218
134TCF4_18268006_ChIP-ChIP_LS174T_Human0.97452823
135* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97437889
136* RING1B_27294783_Chip-Seq_ESCs_Mouse0.97397523
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97026914
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96899503
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96824578
140* RING1B_27294783_Chip-Seq_NPCs_Mouse0.95889101
141* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95038550
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94731547
143* OCT4_18555785_Chip-Seq_ESCs_Mouse0.93900681
144NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93391422
145RUNX2_22187159_ChIP-Seq_PCA_Human0.93059975
146* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92466290
147* E2F1_18555785_Chip-Seq_ESCs_Mouse0.92094102
148EGR1_19374776_ChIP-ChIP_THP-1_Human0.92010227
149ER_23166858_ChIP-Seq_MCF-7_Human0.91458741
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.88835593
151NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88101033
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88101033
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88083372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.86458485
2MP0003880_abnormal_central_pattern4.22763469
3MP0003635_abnormal_synaptic_transmissio3.82591926
4MP0008438_abnormal_cutaneous_collagen3.64358584
5MP0000569_abnormal_digit_pigmentation3.18573757
6MP0004270_analgesia3.18192134
7MP0002063_abnormal_learning/memory/cond3.11608910
8MP0009745_abnormal_behavioral_response3.09311620
9MP0001968_abnormal_touch/_nociception3.07877147
10MP0002064_seizures2.87858140
11MP0009046_muscle_twitch2.84153238
12MP0001958_emphysema2.77160440
13MP0002735_abnormal_chemical_nociception2.62431336
14MP0002572_abnormal_emotion/affect_behav2.60165927
15MP0001501_abnormal_sleep_pattern2.57902378
16MP0010352_gastrointestinal_tract_polyps2.56718088
17MP0005379_endocrine/exocrine_gland_phen2.53460858
18MP0002736_abnormal_nociception_after2.46770199
19MP0002837_dystrophic_cardiac_calcinosis2.42402096
20MP0005423_abnormal_somatic_nervous2.37154548
21MP0002272_abnormal_nervous_system2.28531125
22MP0002734_abnormal_mechanical_nocicepti2.17046884
23MP0006054_spinal_hemorrhage2.16339961
24MP0001486_abnormal_startle_reflex2.15285125
25MP0001440_abnormal_grooming_behavior1.98306986
26MP0009780_abnormal_chondrocyte_physiolo1.96900021
27MP0003787_abnormal_imprinting1.96782478
28MP0002067_abnormal_sensory_capabilities1.90856901
29MP0005275_abnormal_skin_tensile1.83670898
30MP0002909_abnormal_adrenal_gland1.79667369
31MP0002139_abnormal_hepatobiliary_system1.79173607
32MP0008569_lethality_at_weaning1.78072382
33MP0003279_aneurysm1.75021729
34MP0001348_abnormal_lacrimal_gland1.73901019
35MP0004811_abnormal_neuron_physiology1.66760039
36MP0001970_abnormal_pain_threshold1.60728270
37MP0002166_altered_tumor_susceptibility1.59804013
38MP0002822_catalepsy1.58959019
39MP0001944_abnormal_pancreas_morphology1.58287073
40MP0002184_abnormal_innervation1.56453945
41MP0010234_abnormal_vibrissa_follicle1.52776743
42MP0002733_abnormal_thermal_nociception1.52030134
43MP0003566_abnormal_cell_adhesion1.51881331
44MP0002693_abnormal_pancreas_physiology1.50328677
45MP0002557_abnormal_social/conspecific_i1.49282753
46MP0003252_abnormal_bile_duct1.45044738
47MP0004858_abnormal_nervous_system1.44084338
48MP0001188_hyperpigmentation1.43317011
49MP0004510_myositis1.42805856
50MP0002163_abnormal_gland_morphology1.42516155
51MP0002168_other_aberrant_phenotype1.40275742
52MP0003950_abnormal_plasma_membrane1.39545230
53MP0004272_abnormal_basement_membrane1.39124620
54MP0008961_abnormal_basal_metabolism1.38530755
55MP0000778_abnormal_nervous_system1.36716734
56MP0001756_abnormal_urination1.36088940
57MP0000955_abnormal_spinal_cord1.35973252
58MP0003879_abnormal_hair_cell1.33654502
59MP0003195_calcinosis1.32979202
60MP0000013_abnormal_adipose_tissue1.31683694
61MP0005551_abnormal_eye_electrophysiolog1.29740542
62MP0002006_tumorigenesis1.27755984
63* MP0005386_behavior/neurological_phenoty1.27440075
64* MP0004924_abnormal_behavior1.27440075
65MP0002876_abnormal_thyroid_physiology1.26714868
66MP0001984_abnormal_olfaction1.25481095
67MP0002882_abnormal_neuron_morphology1.23386542
68MP0003633_abnormal_nervous_system1.21883384
69MP0001502_abnormal_circadian_rhythm1.19176194
70MP0010678_abnormal_skin_adnexa1.16486650
71MP0004885_abnormal_endolymph1.16179967
72MP0001299_abnormal_eye_distance/1.15519867
73MP0003045_fibrosis1.14962623
74MP0002060_abnormal_skin_morphology1.14353738
75MP0002066_abnormal_motor_capabilities/c1.13329371
76MP0004019_abnormal_vitamin_homeostasis1.12215005
77MP0000685_abnormal_immune_system1.10741120
78MP0010386_abnormal_urinary_bladder1.10740331
79MP0005645_abnormal_hypothalamus_physiol1.09745869
80MP0002254_reproductive_system_inflammat1.09270393
81MP0000604_amyloidosis1.08501269
82MP0008877_abnormal_DNA_methylation1.08267760
83MP0002295_abnormal_pulmonary_circulatio1.04069692
84MP0003690_abnormal_glial_cell1.01515060
85MP0001835_abnormal_antigen_presentation0.98419483
86MP0005023_abnormal_wound_healing0.97513137
87MP0003705_abnormal_hypodermis_morpholog0.97341884
88MP0003183_abnormal_peptide_metabolism0.96431652
89MP0005623_abnormal_meninges_morphology0.95937743
90MP0005646_abnormal_pituitary_gland0.95828704
91MP0000516_abnormal_urinary_system0.95808900
92MP0005367_renal/urinary_system_phenotyp0.95808900
93MP0004134_abnormal_chest_morphology0.95000332
94MP0004484_altered_response_of0.93061826
95MP0003631_nervous_system_phenotype0.93018472
96MP0001177_atelectasis0.91864082
97MP0005166_decreased_susceptibility_to0.91410035
98MP0002090_abnormal_vision0.90647361
99MP0003868_abnormal_feces_composition0.89888229
100MP0000920_abnormal_myelination0.88933745
101MP0003763_abnormal_thymus_physiology0.88372606
102MP0002396_abnormal_hematopoietic_system0.86901750
103MP0005503_abnormal_tendon_morphology0.86317063
104MP0004742_abnormal_vestibular_system0.85527049
105MP0002152_abnormal_brain_morphology0.85020835
106MP0005332_abnormal_amino_acid0.84989405
107MP0003329_amyloid_beta_deposits0.84855013
108MP0002089_abnormal_postnatal_growth/wei0.84840491
109MP0010329_abnormal_lipoprotein_level0.84614837
110MP0006082_CNS_inflammation0.84568725
111MP0009384_cardiac_valve_regurgitation0.83998679
112MP0002136_abnormal_kidney_physiology0.83432385
113MP0003172_abnormal_lysosome_physiology0.83345025
114MP0006276_abnormal_autonomic_nervous0.81910245
115MP0001851_eye_inflammation0.81238752
116MP0002078_abnormal_glucose_homeostasis0.79761389
117MP0000639_abnormal_adrenal_gland0.79090711
118MP0003091_abnormal_cell_migration0.78660234
119MP0002229_neurodegeneration0.78497011
120MP0003075_altered_response_to0.78108056
121MP0002877_abnormal_melanocyte_morpholog0.78078608
122MP0005165_increased_susceptibility_to0.77914236
123MP0005058_abnormal_lysosome_morphology0.77748041
124MP0003300_gastrointestinal_ulcer0.76677832
125MP0004808_abnormal_hematopoietic_stem0.76207385
126MP0004145_abnormal_muscle_electrophysio0.75519941
127MP0001790_abnormal_immune_system0.73836316
128MP0005387_immune_system_phenotype0.73836316
129MP0000427_abnormal_hair_cycle0.73621083
130MP0006072_abnormal_retinal_apoptosis0.73510198
131MP0002998_abnormal_bone_remodeling0.73022323
132MP0008874_decreased_physiological_sensi0.72667899
133MP0003303_peritoneal_inflammation0.72382341
134MP0009643_abnormal_urine_homeostasis0.71919304
135MP0003122_maternal_imprinting0.71865045
136MP0005409_darkened_coat_color0.70978770
137MP0001243_abnormal_dermal_layer0.70840248
138MP0000015_abnormal_ear_pigmentation0.70056032
139MP0004782_abnormal_surfactant_physiolog0.69270389
140MP0002069_abnormal_eating/drinking_beha0.68886744
141MP0005310_abnormal_salivary_gland0.68591407
142MP0004085_abnormal_heartbeat0.68121839
143MP0000230_abnormal_systemic_arterial0.68070755
144MP0005595_abnormal_vascular_smooth0.67723376
145MP0005375_adipose_tissue_phenotype0.67417291
146MP0005535_abnormal_body_temperature0.67302906
147MP0005167_abnormal_blood-brain_barrier0.67184632
148MP0002009_preneoplasia0.66172575
149MP0005253_abnormal_eye_physiology0.65599444
150MP0003634_abnormal_glial_cell0.63007111
151MP0000751_myopathy0.62207231
152MP0002234_abnormal_pharynx_morphology0.61515625
153MP0000003_abnormal_adipose_tissue0.61161299
154MP0004215_abnormal_myocardial_fiber0.60216539
155MP0005174_abnormal_tail_pigmentation0.59391018
156MP0001963_abnormal_hearing_physiology0.59028415
157MP0001765_abnormal_ion_homeostasis0.58564815
158MP0002752_abnormal_somatic_nervous0.53886914
159MP0005171_absent_coat_pigmentation0.52844051
160MP0003632_abnormal_nervous_system0.52647866
161MP0003283_abnormal_digestive_organ0.52110673
162MP0004043_abnormal_pH_regulation0.50944543
163MP0002896_abnormal_bone_mineralization0.50937540
164MP0008872_abnormal_physiological_respon0.50310102

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.95915611
2Focal seizures (HP:0007359)4.78614057
3Febrile seizures (HP:0002373)4.58242383
4Epileptic encephalopathy (HP:0200134)4.45614942
5Myokymia (HP:0002411)4.16740193
6Visual hallucinations (HP:0002367)4.10276326
7Increased CSF protein (HP:0002922)3.89754334
8Progressive cerebellar ataxia (HP:0002073)3.83243640
9Atonic seizures (HP:0010819)3.64374040
10Absence seizures (HP:0002121)3.60927514
11Hyperphosphatemia (HP:0002905)3.47142413
12Cardiovascular calcification (HP:0011915)3.44685993
13Broad-based gait (HP:0002136)3.32083288
14Action tremor (HP:0002345)3.23200892
15Dialeptic seizures (HP:0011146)3.20404852
16Premature rupture of membranes (HP:0001788)3.18707387
17Papilledema (HP:0001085)3.10124251
18Gaze-evoked nystagmus (HP:0000640)3.07516217
19Vascular calcification (HP:0004934)3.05498201
20Poor eye contact (HP:0000817)3.04247023
21Generalized tonic-clonic seizures (HP:0002069)2.96445104
22Truncal ataxia (HP:0002078)2.92729477
23Urinary glycosaminoglycan excretion (HP:0003541)2.91227971
24Mucopolysacchariduria (HP:0008155)2.91227971
25Genetic anticipation (HP:0003743)2.87044326
26Mitral stenosis (HP:0001718)2.84390022
27Abnormality of polysaccharide metabolism (HP:0011012)2.83194105
28Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83194105
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83194105
30Hematochezia (HP:0002573)2.79718805
31Drooling (HP:0002307)2.77403336
32Excessive salivation (HP:0003781)2.77403336
33Impaired smooth pursuit (HP:0007772)2.74088289
34Impaired social interactions (HP:0000735)2.70232176
35Abnormal social behavior (HP:0012433)2.70232176
36Atrophic scars (HP:0001075)2.69297559
37Abnormality of calcium-phosphate metabolism (HP:0100530)2.66837140
38Increased circulating renin level (HP:0000848)2.66622935
39Hypoventilation (HP:0002791)2.57897793
40Amblyopia (HP:0000646)2.56038991
41Dysmetric saccades (HP:0000641)2.54179588
42Aortic dissection (HP:0002647)2.52227948
43Inappropriate behavior (HP:0000719)2.51681218
44Dysdiadochokinesis (HP:0002075)2.50847412
45Macroorchidism (HP:0000053)2.48013425
46Congenital stationary night blindness (HP:0007642)2.45852930
47Aqueductal stenosis (HP:0002410)2.42872663
48Supranuclear gaze palsy (HP:0000605)2.40278146
49Urinary bladder sphincter dysfunction (HP:0002839)2.39637550
50Postural instability (HP:0002172)2.39306358
51Hyperglycemia (HP:0003074)2.39053075
52Depression (HP:0000716)2.37963075
53Aortic aneurysm (HP:0004942)2.37363800
54Abnormality of ocular smooth pursuit (HP:0000617)2.35965796
55Shoulder girdle muscle weakness (HP:0003547)2.35600652
56Absent frontal sinuses (HP:0002688)2.35062900
57Dysostosis multiplex (HP:0000943)2.31493056
58Orthostatic hypotension (HP:0001278)2.26762981
59Protruding tongue (HP:0010808)2.26341232
60Urethral obstruction (HP:0000796)2.25887420
61Stereotypic behavior (HP:0000733)2.25542024
62Dysmetria (HP:0001310)2.24553232
63Glucose intolerance (HP:0000833)2.23959418
64Diplopia (HP:0000651)2.23767872
65Abnormality of binocular vision (HP:0011514)2.23767872
66Mutism (HP:0002300)2.23104804
67Impaired vibration sensation in the lower limbs (HP:0002166)2.22833953
68Pelvic girdle muscle weakness (HP:0003749)2.20365350
69Absent speech (HP:0001344)2.18198608
70Protrusio acetabuli (HP:0003179)2.17995102
71Lower limb amyotrophy (HP:0007210)2.16350445
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15428919
73Metabolic alkalosis (HP:0200114)2.15176073
74Tetraparesis (HP:0002273)2.15155177
75Scanning speech (HP:0002168)2.14518486
76Hyperventilation (HP:0002883)2.14065059
77Osteolytic defects of the hand bones (HP:0009699)2.14062530
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.14062530
79Striae distensae (HP:0001065)2.12307296
80Postural tremor (HP:0002174)2.12019783
81Interstitial pulmonary disease (HP:0006530)2.11954536
82Abnormal glucose tolerance (HP:0001952)2.10578717
83Hemiplegia (HP:0002301)2.10050706
84Episodic fever (HP:0001954)2.09469102
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08613711
86Neurofibrillary tangles (HP:0002185)2.07903315
87Spondylolisthesis (HP:0003302)2.06801355
88Widely spaced teeth (HP:0000687)2.05972473
89Thoracolumbar scoliosis (HP:0002944)2.05347207
90Thin bony cortex (HP:0002753)2.02563520
91Enlarged penis (HP:0000040)2.01832375
92Abnormality of the musculature of the pelvis (HP:0001469)2.01670550
93Abnormality of the hip-girdle musculature (HP:0001445)2.01670550
94Malnutrition (HP:0004395)2.01237090
95Urinary urgency (HP:0000012)2.01216793
96Testicular neoplasm (HP:0010788)1.99501441
97Lower limb asymmetry (HP:0100559)1.97947669
98Chronic diarrhea (HP:0002028)1.97840034
99Hypokalemic alkalosis (HP:0001949)1.97402909
100Overgrowth (HP:0001548)1.97130043
101Abnormality of salivation (HP:0100755)1.95970054
102Frequent falls (HP:0002359)1.95062103
103Tetany (HP:0001281)1.95010088
104Hypoalbuminemia (HP:0003073)1.94870208
105Abnormal albumin level (HP:0012116)1.94870208
106Pointed chin (HP:0000307)1.94771170
107Progressive neurologic deterioration (HP:0002344)1.94723466
108Metaphyseal dysplasia (HP:0100255)1.94487903
109Hamartoma of the eye (HP:0010568)1.94033801
110Abnormality of vitamin B metabolism (HP:0004340)1.93873238
111Exotropia (HP:0000577)1.91414863
112Central scotoma (HP:0000603)1.90679508
113Menstrual irregularities (HP:0000858)1.90323300
114Abnormality of vitamin metabolism (HP:0100508)1.90026783
115Intellectual disability, profound (HP:0002187)1.89537562
116Short chin (HP:0000331)1.89422274
117Cerebral aneurysm (HP:0004944)1.88982497
118Anxiety (HP:0000739)1.88411353
119Blue irides (HP:0000635)1.87940488
120Hemiparesis (HP:0001269)1.87883664
121Dilatation of the ascending aorta (HP:0005111)1.86670620
122Abnormality of liposaccharide metabolism (HP:0010968)1.85013605
123Abnormality of glycosphingolipid metabolism (HP:0004343)1.85013605
124Abnormality of glycolipid metabolism (HP:0010969)1.85013605
125Abnormality of proline metabolism (HP:0010907)1.84729887
126Hydroxyprolinuria (HP:0003080)1.84729887
127Hypoplasia of dental enamel (HP:0006297)1.81359038
128Bradykinesia (HP:0002067)1.80795434
129Ankle clonus (HP:0011448)1.80785282
130Achilles tendon contracture (HP:0001771)1.80771384
131Abnormal eating behavior (HP:0100738)1.80706048
132Type II lissencephaly (HP:0007260)1.79906571
133Proximal tubulopathy (HP:0000114)1.79570114
134Abnormality of macular pigmentation (HP:0008002)1.79293615
135Epileptiform EEG discharges (HP:0011182)1.79251339
136Cardiomegaly (HP:0001640)1.79213918
137Open mouth (HP:0000194)1.79130266
138Albinism (HP:0001022)1.78841533
139Resting tremor (HP:0002322)1.78489883
140Ankyloglossia (HP:0010296)1.74951948
141Congenital sensorineural hearing impairment (HP:0008527)1.73549427
142Cerebral inclusion bodies (HP:0100314)1.73540444
143Fragile skin (HP:0001030)1.73421551
144Cubitus valgus (HP:0002967)1.73337975
145Sensory axonal neuropathy (HP:0003390)1.72382607
146Obstructive sleep apnea (HP:0002870)1.72225591
147Persistence of primary teeth (HP:0006335)1.71703712
148Generalized hypopigmentation of hair (HP:0011358)1.70137734
149Obsessive-compulsive behavior (HP:0000722)1.70041777
150Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69279230
151Agitation (HP:0000713)1.68905365
152EEG with generalized epileptiform discharges (HP:0011198)1.67477991
153Double outlet right ventricle (HP:0001719)1.67056628
154Congenital malformation of the right heart (HP:0011723)1.67056628
155Hyperextensible skin (HP:0000974)1.66854028
156Follicular hyperkeratosis (HP:0007502)1.66810309
157Wormian bones (HP:0002645)1.65272889
158Mitral valve prolapse (HP:0001634)1.65114419
159Progressive inability to walk (HP:0002505)1.64616804
160Tetraplegia (HP:0002445)1.63155662
161Arterial tortuosity (HP:0005116)1.62858400
162Intention tremor (HP:0002080)1.62738441
163Vacuolated lymphocytes (HP:0001922)1.60662783
164Deeply set eye (HP:0000490)1.60374410
165Termporal pattern (HP:0011008)1.60286080
166Insidious onset (HP:0003587)1.60286080
167Limb-girdle muscle atrophy (HP:0003797)1.60184701
168Relative macrocephaly (HP:0004482)1.60177980
169Cheilitis (HP:0100825)1.59129472
170Hypothermia (HP:0002045)1.58712650
171Focal segmental glomerulosclerosis (HP:0000097)1.57964119
172Hyperaldosteronism (HP:0000859)1.57491649
173Abnormality of the lower motor neuron (HP:0002366)1.54761178
174Megalencephaly (HP:0001355)1.54336061
175Bundle branch block (HP:0011710)1.54054069
176Abnormality of oral frenula (HP:0000190)1.53662421
177Deep palmar crease (HP:0006191)1.51857424
178Ventricular fibrillation (HP:0001663)1.51843747
179Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.51038511
180Vascular tortuosity (HP:0004948)1.50186395
181Abnormal EKG (HP:0003115)1.49921264
182Impaired vibratory sensation (HP:0002495)1.49414927
183Macroglossia (HP:0000158)1.48529794
184Spinal canal stenosis (HP:0003416)1.48433530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.72825108
2EPHA43.84065461
3MAP3K93.42633732
4RIPK42.90427597
5MAP3K42.88216486
6DAPK22.35821658
7TRPM72.30368410
8MINK12.27364804
9MAP2K72.14656473
10PAK62.13603877
11CAMKK12.13146673
12MARK12.03985943
13CAMKK21.90333636
14KSR21.87897127
15PRKD31.84482708
16AKT31.80758945
17MAP3K131.79505904
18STK241.77407325
19SIK21.73619895
20MAP3K21.70342360
21NTRK21.67364476
22STK381.59480395
23PLK21.59249407
24MAP3K141.56643832
25FGFR41.56541518
26NEK91.54492043
27FRK1.54216732
28KSR11.53738239
29MAP2K41.50780067
30MYLK1.45536568
31NLK1.44707491
32CDK51.44168221
33MAP3K121.38892839
34NTRK11.37839293
35DAPK11.35649138
36FES1.34297061
37MST41.31186738
38CAMK1G1.30466150
39PHKG21.21889414
40PHKG11.21889414
41SGK21.20155662
42SGK31.18385263
43ALK1.17849552
44SGK11.15918578
45MAP2K61.15830611
46PRKCH1.15117776
47STK31.11943572
48RET1.11265785
49RIPK11.08056246
50PRPF4B1.05921229
51SCYL21.05190479
52PTK21.04606601
53TNIK1.01311181
54LATS20.99713984
55STK110.99677413
56CAMK10.98368895
57MST1R0.98237741
58WNK10.97701570
59PRKG20.97650992
60GRK50.96777770
61PTK2B0.95719744
62TTN0.92943214
63BMPR20.91408293
64DMPK0.91106821
65SGK4940.89272746
66SGK2230.89272746
67CAMK1D0.87311454
68FER0.85894974
69WNK30.85327131
70TYRO30.84007521
71MAP3K70.83835367
72MAPK130.83254230
73PAK30.83037089
74EIF2AK30.82499777
75ERBB30.82451988
76PRKCG0.82321018
77PDK10.82150382
78STK38L0.81416725
79CAMK2A0.79739691
80TAOK10.79164931
81TYK20.77776633
82MAPK110.75471203
83CASK0.73065093
84PRKD20.71899779
85DYRK1A0.71501861
86STK390.71109367
87MAP3K10.69178713
88YES10.68759095
89MET0.68713815
90DDR20.68576145
91JAK10.66340713
92RAF10.66256449
93MAPK70.65958955
94PINK10.65663223
95UHMK10.65425041
96PNCK0.65203516
97FGFR30.63317648
98ACVR1B0.62855072
99ITK0.62506857
100TNK20.62503040
101PDGFRA0.61719236
102PAK20.61653802
103JAK30.60776808
104MAP3K30.58671457
105TEC0.58069789
106ARAF0.57631929
107GRK10.57446919
108MARK20.57414654
109RPS6KA30.57233830
110PDGFRB0.55706396
111ROCK20.55522541
112CDC42BPA0.55397201
113EPHB10.55293465
114FGFR20.54396119
115MAPK100.54045716
116PDPK10.53853177
117IRAK30.53421828
118GSK3A0.52814998
119CDK180.52600390
120CAMK40.52153644
121CAMK2B0.52069873
122FYN0.51727911
123CDK150.51668812
124LATS10.51113629
125MAPK120.50475172
126MOS0.50310042
127CDK140.49301613
128MAP3K60.48819160
129PRKCB0.47557997
130MAP2K10.47386161
131PRKCE0.47074691
132PIK3CG0.44808466
133EPHA30.44528589
134ZAP700.44413855
135LMTK20.42674212
136OXSR10.42457820
137HIPK20.42434140
138KIT0.42376657
139CDK120.40484834
140CDK11A0.40346434
141NEK60.39061925
142MAPK80.38992744
143FGR0.37934097
144CAMK2D0.36355573
145HCK0.36314183
146SIK30.36012303
147CSNK1G20.33055211
148PRKCZ0.33010408
149SRC0.32039677

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.98049903
2Long-term potentiation_Homo sapiens_hsa047202.50372360
3Synaptic vesicle cycle_Homo sapiens_hsa047212.38954823
4Circadian entrainment_Homo sapiens_hsa047132.32438861
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18438628
6Olfactory transduction_Homo sapiens_hsa047402.14099056
7* Glutamatergic synapse_Homo sapiens_hsa047242.13746160
8Amphetamine addiction_Homo sapiens_hsa050312.06937132
9Morphine addiction_Homo sapiens_hsa050322.02270459
10Vitamin B6 metabolism_Homo sapiens_hsa007501.96822728
11* GABAergic synapse_Homo sapiens_hsa047271.93588377
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93190996
13Salivary secretion_Homo sapiens_hsa049701.88699050
14Dopaminergic synapse_Homo sapiens_hsa047281.77803919
15Insulin secretion_Homo sapiens_hsa049111.71812766
16Gastric acid secretion_Homo sapiens_hsa049711.71771500
17Long-term depression_Homo sapiens_hsa047301.68527564
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64888951
19Cholinergic synapse_Homo sapiens_hsa047251.62654367
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.61312390
21Renin secretion_Homo sapiens_hsa049241.58110269
22Oxytocin signaling pathway_Homo sapiens_hsa049211.56794233
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56782911
24Sphingolipid metabolism_Homo sapiens_hsa006001.47506693
25Sulfur metabolism_Homo sapiens_hsa009201.43003636
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39321157
27GnRH signaling pathway_Homo sapiens_hsa049121.37949736
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37246257
29Taste transduction_Homo sapiens_hsa047421.34262983
30Type II diabetes mellitus_Homo sapiens_hsa049301.33408889
31Phototransduction_Homo sapiens_hsa047441.32147584
32Serotonergic synapse_Homo sapiens_hsa047261.30995332
33Calcium signaling pathway_Homo sapiens_hsa040201.29626444
34Cocaine addiction_Homo sapiens_hsa050301.29297649
35Glioma_Homo sapiens_hsa052141.24567019
36cAMP signaling pathway_Homo sapiens_hsa040241.21068942
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20806995
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20578648
39Protein digestion and absorption_Homo sapiens_hsa049741.16348634
40Estrogen signaling pathway_Homo sapiens_hsa049151.12118767
41ErbB signaling pathway_Homo sapiens_hsa040121.11171043
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.11127780
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09220297
44ECM-receptor interaction_Homo sapiens_hsa045121.09052792
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08776831
46Gap junction_Homo sapiens_hsa045401.08699131
47Other glycan degradation_Homo sapiens_hsa005111.07182443
48Dorso-ventral axis formation_Homo sapiens_hsa043200.95701232
49Axon guidance_Homo sapiens_hsa043600.95174203
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94196371
51mTOR signaling pathway_Homo sapiens_hsa041500.93893562
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91263801
53Collecting duct acid secretion_Homo sapiens_hsa049660.90917749
54Thyroid hormone synthesis_Homo sapiens_hsa049180.89989471
55Melanogenesis_Homo sapiens_hsa049160.88039063
56Choline metabolism in cancer_Homo sapiens_hsa052310.87289240
57MAPK signaling pathway_Homo sapiens_hsa040100.87021681
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.86619566
59Lysosome_Homo sapiens_hsa041420.85769637
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85062838
61Vibrio cholerae infection_Homo sapiens_hsa051100.84708802
62VEGF signaling pathway_Homo sapiens_hsa043700.84582026
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.84513335
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.84378480
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84368117
66Inositol phosphate metabolism_Homo sapiens_hsa005620.83868425
67Folate biosynthesis_Homo sapiens_hsa007900.83757510
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83702007
69Pancreatic secretion_Homo sapiens_hsa049720.83659889
70Dilated cardiomyopathy_Homo sapiens_hsa054140.83513607
71Selenocompound metabolism_Homo sapiens_hsa004500.82737872
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80697673
73Type I diabetes mellitus_Homo sapiens_hsa049400.79465517
74Amoebiasis_Homo sapiens_hsa051460.76357401
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.76142672
76Oocyte meiosis_Homo sapiens_hsa041140.73815604
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72481471
78Ether lipid metabolism_Homo sapiens_hsa005650.70443105
79Renin-angiotensin system_Homo sapiens_hsa046140.70231392
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69218304
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68021890
82Circadian rhythm_Homo sapiens_hsa047100.67923537
83Rap1 signaling pathway_Homo sapiens_hsa040150.66897710
84Chemokine signaling pathway_Homo sapiens_hsa040620.66798878
85Non-small cell lung cancer_Homo sapiens_hsa052230.65075483
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64989096
87Endometrial cancer_Homo sapiens_hsa052130.64661768
88Ras signaling pathway_Homo sapiens_hsa040140.64122046
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63944145
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63706183
91Toxoplasmosis_Homo sapiens_hsa051450.63672685
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63271876
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.63178977
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61998004
95TNF signaling pathway_Homo sapiens_hsa046680.61218544
96Platelet activation_Homo sapiens_hsa046110.61133966
97T cell receptor signaling pathway_Homo sapiens_hsa046600.60310728
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60229836
99* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59644046
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59317589
101Renal cell carcinoma_Homo sapiens_hsa052110.57516107
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55571953
103Osteoclast differentiation_Homo sapiens_hsa043800.55552356
104Insulin resistance_Homo sapiens_hsa049310.54839627
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54783746
106Small cell lung cancer_Homo sapiens_hsa052220.54725516
107ABC transporters_Homo sapiens_hsa020100.54688229
108African trypanosomiasis_Homo sapiens_hsa051430.54142945
109FoxO signaling pathway_Homo sapiens_hsa040680.53958382
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53587312
111Endocytosis_Homo sapiens_hsa041440.53138540
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52931994
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51604442
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51522423
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50371598
116Bile secretion_Homo sapiens_hsa049760.50045116
117Glucagon signaling pathway_Homo sapiens_hsa049220.49684058
118B cell receptor signaling pathway_Homo sapiens_hsa046620.49554311
119Hepatitis C_Homo sapiens_hsa051600.49410866
120Pertussis_Homo sapiens_hsa051330.49370712
121Proteoglycans in cancer_Homo sapiens_hsa052050.49164434
122Chronic myeloid leukemia_Homo sapiens_hsa052200.49155326
123Prolactin signaling pathway_Homo sapiens_hsa049170.48661135
124Focal adhesion_Homo sapiens_hsa045100.48613889
125Alcoholism_Homo sapiens_hsa050340.48308619
126Wnt signaling pathway_Homo sapiens_hsa043100.48272744
127Mineral absorption_Homo sapiens_hsa049780.48244683
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47766364

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