GLS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.53197962
2omega-hydroxylase P450 pathway (GO:0097267)8.47826645
3exogenous drug catabolic process (GO:0042738)8.38162528
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.82048111
5L-phenylalanine catabolic process (GO:0006559)7.82048111
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.46796444
7L-phenylalanine metabolic process (GO:0006558)7.46796444
8aromatic amino acid family catabolic process (GO:0009074)6.99543274
9tryptophan catabolic process (GO:0006569)6.27395246
10indole-containing compound catabolic process (GO:0042436)6.27395246
11indolalkylamine catabolic process (GO:0046218)6.27395246
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.25756402
13kynurenine metabolic process (GO:0070189)6.13656081
14bile acid biosynthetic process (GO:0006699)5.98128886
15tryptophan metabolic process (GO:0006568)5.89816263
16urea metabolic process (GO:0019627)5.86225463
17urea cycle (GO:0000050)5.86225463
18glyoxylate metabolic process (GO:0046487)5.76217828
19oxidative demethylation (GO:0070989)5.68673498
20drug metabolic process (GO:0017144)5.68673395
21cysteine metabolic process (GO:0006534)5.62308324
22negative regulation of fibrinolysis (GO:0051918)5.58684912
23high-density lipoprotein particle remodeling (GO:0034375)5.52496714
24sulfur amino acid catabolic process (GO:0000098)5.50290509
25alpha-linolenic acid metabolic process (GO:0036109)5.46325457
26ethanol metabolic process (GO:0006067)5.41280392
27nitrogen cycle metabolic process (GO:0071941)5.39560395
28regulation of fibrinolysis (GO:0051917)5.38502321
29peptidyl-glutamic acid carboxylation (GO:0017187)5.37452931
30protein carboxylation (GO:0018214)5.37452931
31serine family amino acid catabolic process (GO:0009071)5.35598373
32complement activation, alternative pathway (GO:0006957)5.33039541
33regulation of protein activation cascade (GO:2000257)5.31002546
34bile acid metabolic process (GO:0008206)5.11907449
35homocysteine metabolic process (GO:0050667)5.10137756
36aromatic amino acid family metabolic process (GO:0009072)5.09538050
37phenylpropanoid metabolic process (GO:0009698)4.99197699
38regulation of complement activation (GO:0030449)4.96025951
39tyrosine metabolic process (GO:0006570)4.90996516
40alpha-amino acid catabolic process (GO:1901606)4.81965359
41regulation of cholesterol esterification (GO:0010872)4.80046756
42reverse cholesterol transport (GO:0043691)4.78119069
43regulation of triglyceride catabolic process (GO:0010896)4.73570794
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.72410176
45plasma lipoprotein particle remodeling (GO:0034369)4.71275414
46protein-lipid complex remodeling (GO:0034368)4.71275414
47macromolecular complex remodeling (GO:0034367)4.71275414
48lysine metabolic process (GO:0006553)4.67959813
49lysine catabolic process (GO:0006554)4.67959813
50glycine metabolic process (GO:0006544)4.66006120
51amino-acid betaine metabolic process (GO:0006577)4.61384105
52acylglycerol homeostasis (GO:0055090)4.59044910
53triglyceride homeostasis (GO:0070328)4.59044910
54negative regulation of sterol transport (GO:0032372)4.56558143
55negative regulation of cholesterol transport (GO:0032375)4.56558143
56coenzyme catabolic process (GO:0009109)4.55682580
57imidazole-containing compound metabolic process (GO:0052803)4.55267587
58phospholipid efflux (GO:0033700)4.45883246
59indolalkylamine metabolic process (GO:0006586)4.44351584
60cellular amino acid catabolic process (GO:0009063)4.43854523
61regulation of plasminogen activation (GO:0010755)4.43008905
62bile acid and bile salt transport (GO:0015721)4.42237701
63glutamate metabolic process (GO:0006536)4.41888117
64serine family amino acid metabolic process (GO:0009069)4.40088525
65cellular ketone body metabolic process (GO:0046950)4.39102382
66amine catabolic process (GO:0009310)4.35488641
67cellular biogenic amine catabolic process (GO:0042402)4.35488641
68S-adenosylmethionine metabolic process (GO:0046500)4.32758635
69plasma lipoprotein particle clearance (GO:0034381)4.30288009
70serine family amino acid biosynthetic process (GO:0009070)4.27424202
71cellular glucuronidation (GO:0052695)4.24455995
72cellular modified amino acid catabolic process (GO:0042219)4.23297803
73dicarboxylic acid biosynthetic process (GO:0043650)4.15930213
74cholesterol efflux (GO:0033344)4.15771026
75benzene-containing compound metabolic process (GO:0042537)4.14955690
76arginine metabolic process (GO:0006525)4.13557719
77ethanol oxidation (GO:0006069)4.08968279
78aldehyde catabolic process (GO:0046185)3.99277057
79low-density lipoprotein particle remodeling (GO:0034374)3.99198948
80fibrinolysis (GO:0042730)3.95067523
81plasma lipoprotein particle assembly (GO:0034377)3.91616594
82drug catabolic process (GO:0042737)3.91180927
83cofactor catabolic process (GO:0051187)3.86640198
84negative regulation of blood coagulation (GO:0030195)3.84138363
85negative regulation of hemostasis (GO:1900047)3.84138363
86opsonization (GO:0008228)3.82624887
87organic acid catabolic process (GO:0016054)3.82069670
88carboxylic acid catabolic process (GO:0046395)3.82069670
89regulation of bile acid biosynthetic process (GO:0070857)3.81697799
90blood coagulation, intrinsic pathway (GO:0007597)3.81273868
91alkaloid metabolic process (GO:0009820)3.79983327
92ketone body metabolic process (GO:1902224)3.79791270
93regulation of humoral immune response (GO:0002920)3.79001263
94complement activation, classical pathway (GO:0006958)3.75830671
95uronic acid metabolic process (GO:0006063)3.75159313
96glucuronate metabolic process (GO:0019585)3.75159313
97very-low-density lipoprotein particle assembly (GO:0034379)3.72383158
98complement activation (GO:0006956)3.71110468
99cholesterol homeostasis (GO:0042632)3.71071551
100acetyl-CoA metabolic process (GO:0006084)3.70853015
101acute-phase response (GO:0006953)3.68855331
102positive regulation of triglyceride lipase activity (GO:0061365)3.68401388
103positive regulation of lipoprotein lipase activity (GO:0051006)3.68401388
104negative regulation of lipase activity (GO:0060192)3.68216679
105protein activation cascade (GO:0072376)3.68030395
106intestinal cholesterol absorption (GO:0030299)3.68013586
107short-chain fatty acid metabolic process (GO:0046459)3.67602577
108cytolysis (GO:0019835)3.67452839
109regulation of cholesterol homeostasis (GO:2000188)3.66469171
110phospholipid homeostasis (GO:0055091)3.65946329
111positive regulation of lipid catabolic process (GO:0050996)3.65089952
112sterol homeostasis (GO:0055092)3.64913933
113negative regulation of protein activation cascade (GO:2000258)3.63111740
114killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.61946663
115disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.61946663
116NAD biosynthetic process (GO:0009435)3.59727176
117aspartate family amino acid catabolic process (GO:0009068)3.59706887
118plasma lipoprotein particle organization (GO:0071827)3.55268350
119negative regulation of wound healing (GO:0061045)3.48224487
120negative regulation of coagulation (GO:0050819)3.43058109
121flavonoid metabolic process (GO:0009812)3.35020050
122heme transport (GO:0015886)3.32230433
123steroid catabolic process (GO:0006706)3.31275498
124proline metabolic process (GO:0006560)3.30300987
125positive regulation of blood coagulation (GO:0030194)3.27330156
126positive regulation of hemostasis (GO:1900048)3.27330156
127oxaloacetate metabolic process (GO:0006107)3.25455555
128L-serine metabolic process (GO:0006563)3.25267378
129pyrimidine nucleobase catabolic process (GO:0006208)3.20959791
130xenobiotic metabolic process (GO:0006805)3.16759637
131positive regulation of coagulation (GO:0050820)3.06479260
132synaptic vesicle maturation (GO:0016188)3.05560233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.44643343
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.24761677
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.03205187
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.51283066
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.43636590
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.17967986
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.71723151
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06617009
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05263117
10REST_21632747_ChIP-Seq_MESCs_Mouse2.23951658
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.12681239
12GBX2_23144817_ChIP-Seq_PC3_Human2.11440128
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08831642
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.1115525
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99450537
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98176967
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95090834
18EZH2_22144423_ChIP-Seq_EOC_Human1.83758249
19DROSHA_22980978_ChIP-Seq_HELA_Human1.76576069
20HTT_18923047_ChIP-ChIP_STHdh_Human1.62255599
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.60278934
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57758561
23* RARB_27405468_Chip-Seq_BRAIN_Mouse1.55482566
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48817350
25CLOCK_20551151_ChIP-Seq_293T_Human1.47229471
26HNF4A_19822575_ChIP-Seq_HepG2_Human1.42298040
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41285928
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38616306
29DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31225096
30GATA1_22025678_ChIP-Seq_K562_Human1.30869583
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.30398603
32* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29333973
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28922244
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25399546
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22149331
36* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20399936
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18553257
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13308877
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12251565
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08712751
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04227134
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00280994
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99775613
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94919983
45EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94376443
46RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94376443
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92638007
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91976270
49JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90816915
50SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90191972
51JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90084849
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89881611
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89196206
54CTCF_27219007_Chip-Seq_Bcells_Human0.89194139
55PIAS1_25552417_ChIP-Seq_VCAP_Human0.87991577
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87545434
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84440696
58AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84298602
59CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83800581
60SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83366815
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.82737425
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81456054
63ZNF263_19887448_ChIP-Seq_K562_Human0.80238517
64KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80191883
65GATA4_25053715_ChIP-Seq_YYC3_Human0.79517933
66EED_16625203_ChIP-ChIP_MESCs_Mouse0.79352836
67RARA_24833708_ChIP-Seq_LIVER_Mouse0.78574379
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.78405124
69SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78326261
70MYC_19829295_ChIP-Seq_ESCs_Human0.77876178
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77736182
72POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77036364
73NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76923584
74ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76746866
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76677986
76SOX2_21211035_ChIP-Seq_LN229_Human0.75873305
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75506442
78AR_19668381_ChIP-Seq_PC3_Human0.75081458
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74617776
80SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74570494
81SMAD4_21799915_ChIP-Seq_A2780_Human0.74447971
82SMC4_20622854_ChIP-Seq_HELA_Human0.73923101
83RARG_19884340_ChIP-ChIP_MEFs_Mouse0.73505312
84EZH2_27304074_Chip-Seq_ESCs_Mouse0.71745754
85TP53_18474530_ChIP-ChIP_U2OS_Human0.71117043
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.71034348
87NR3C1_23031785_ChIP-Seq_PC12_Mouse0.70671769
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.70568690
89PHF8_20622853_ChIP-Seq_HELA_Human0.70494436
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70451021
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69893971
92TCF4_23295773_ChIP-Seq_U87_Human0.69885943
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69705639
94GATA3_21867929_ChIP-Seq_CD8_Mouse0.68633369
95RAC3_21632823_ChIP-Seq_H3396_Human0.66249549
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66220553
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.65660902
98RARB_24833708_ChIP-Seq_LIVER_Mouse0.65548900
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65430987
100STAT3_23295773_ChIP-Seq_U87_Human0.65287910
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.65204581
102RNF2_27304074_Chip-Seq_ESCs_Mouse0.63904312
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.63863467
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63528307
105ZFP57_27257070_Chip-Seq_ESCs_Mouse0.62445684
106KLF5_20875108_ChIP-Seq_MESCs_Mouse0.62285111
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62248857
108RUNX2_22187159_ChIP-Seq_PCA_Human0.61896198
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.61675876
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61280633
111CBX2_22325352_ChIP-Seq_293T-Rex_Human0.60494172
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60426846
113CTCF_20526341_ChIP-Seq_ESCs_Human0.59575878
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.59545172
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59191601
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58842220
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58842220
118CEBPB_22108803_ChIP-Seq_LS180_Human0.56780140
119TAF15_26573619_Chip-Seq_HEK293_Human0.55582823
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.55380523
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.54372609
122MYC_19915707_ChIP-ChIP_AK7_Human0.53190405
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52419039
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.51965364
125LXR_22292898_ChIP-Seq_THP-1_Human0.51864485
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.51431087
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51352050
128AR_20517297_ChIP-Seq_VCAP_Human0.49929024
129EGR1_19032775_ChIP-ChIP_M12_Human0.49828652
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.49605757
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49278506
132CBP_21632823_ChIP-Seq_H3396_Human0.48979017
133P53_21459846_ChIP-Seq_SAOS-2_Human0.48332615
134STAT1_17558387_ChIP-Seq_HELA_Human0.46368942
135TAF2_19829295_ChIP-Seq_ESCs_Human0.45298786
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44255178
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43477679
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.43174600
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42922161
140* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.40215218
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39812384
142GATA6_25053715_ChIP-Seq_YYC3_Human0.39063603
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38903951
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38724655
145ESR1_21235772_ChIP-Seq_MCF-7_Human0.38395449
146IRF1_19129219_ChIP-ChIP_H3396_Human0.38078518
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.37300145
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.37271277
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.37146722
150NCOR_22424771_ChIP-Seq_293T_Human0.36970329
151MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.36929545
152SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.36234070
153GATA1_19941826_ChIP-Seq_K562_Human0.36215960
154* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35920392
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.35756833
156BCAT_22108803_ChIP-Seq_LS180_Human0.35731511
157GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.35357553
158FOXH1_21741376_ChIP-Seq_EPCs_Human0.35117176
159SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34251037
160* SPI1_26923725_Chip-Seq_HPCs_Mouse0.34220333
161PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.33853204
162CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33635600

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.26389508
2MP0005360_urolithiasis7.59699988
3MP0005085_abnormal_gallbladder_physiolo6.55753641
4MP0005365_abnormal_bile_salt6.33039242
5MP0008875_abnormal_xenobiotic_pharmacok5.11306794
6MP0003806_abnormal_nucleotide_metabolis4.34442193
7MP0003252_abnormal_bile_duct3.87312342
8MP0010329_abnormal_lipoprotein_level3.58044978
9MP0005083_abnormal_biliary_tract3.29017274
10MP0009840_abnormal_foam_cell3.24197915
11MP0003195_calcinosis2.88068773
12MP0005332_abnormal_amino_acid2.83710924
13MP0001666_abnormal_nutrient_absorption2.80279155
14MP0004859_abnormal_synaptic_plasticity2.59046097
15MP0003880_abnormal_central_pattern2.31524525
16MP0003191_abnormal_cellular_cholesterol2.19939402
17MP0000609_abnormal_liver_physiology2.14034984
18MP0002118_abnormal_lipid_homeostasis2.11938440
19MP0004019_abnormal_vitamin_homeostasis2.11508853
20MP0003868_abnormal_feces_composition2.06289712
21MP0004270_analgesia1.96795097
22MP0002138_abnormal_hepatobiliary_system1.91335863
23MP0005319_abnormal_enzyme/_coenzyme1.82054739
24MP0009745_abnormal_behavioral_response1.79993907
25MP0002064_seizures1.78463615
26MP0003879_abnormal_hair_cell1.74735358
27MP0001764_abnormal_homeostasis1.74413367
28MP0003635_abnormal_synaptic_transmissio1.70023962
29MP0009697_abnormal_copulation1.56704322
30MP0005584_abnormal_enzyme/coenzyme_acti1.56033539
31MP0009046_muscle_twitch1.48799154
32MP0005451_abnormal_body_composition1.47261664
33MP0002063_abnormal_learning/memory/cond1.45544432
34MP0002272_abnormal_nervous_system1.40608408
35MP0003011_delayed_dark_adaptation1.28726123
36MP0001968_abnormal_touch/_nociception1.27272050
37MP0003186_abnormal_redox_activity1.26157563
38MP0005423_abnormal_somatic_nervous1.25097172
39MP0003656_abnormal_erythrocyte_physiolo1.23136901
40MP0009643_abnormal_urine_homeostasis1.20245225
41MP0003705_abnormal_hypodermis_morpholog1.18815780
42MP0001986_abnormal_taste_sensitivity1.18755022
43MP0000598_abnormal_liver_morphology1.17209414
44MP0002736_abnormal_nociception_after1.15343430
45MP0002572_abnormal_emotion/affect_behav1.15300189
46MP0002735_abnormal_chemical_nociception1.14722162
47MP0003123_paternal_imprinting1.14337297
48MP0005647_abnormal_sex_gland1.12640004
49MP0002734_abnormal_mechanical_nocicepti1.10680748
50MP0005646_abnormal_pituitary_gland1.08577404
51MP0001501_abnormal_sleep_pattern1.07089726
52MP0000604_amyloidosis1.06534422
53MP0001486_abnormal_startle_reflex1.05328929
54MP0002909_abnormal_adrenal_gland1.02995597
55MP0001984_abnormal_olfaction0.99917194
56MP0009763_increased_sensitivity_to0.98340868
57MP0009764_decreased_sensitivity_to0.97451049
58MP0002254_reproductive_system_inflammat0.97274491
59MP0003787_abnormal_imprinting0.97274231
60MP0001440_abnormal_grooming_behavior0.95549812
61MP0003633_abnormal_nervous_system0.90803564
62MP0005636_abnormal_mineral_homeostasis0.88075250
63MP0005220_abnormal_exocrine_pancreas0.86988929
64MP0005084_abnormal_gallbladder_morpholo0.86713560
65MP0006036_abnormal_mitochondrial_physio0.85938243
66MP0009642_abnormal_blood_homeostasis0.85598769
67MP0008469_abnormal_protein_level0.83575971
68MP0005408_hypopigmentation0.83033246
69MP0005187_abnormal_penis_morphology0.82601793
70MP0010368_abnormal_lymphatic_system0.81853239
71MP0005376_homeostasis/metabolism_phenot0.81323409
72MP0002876_abnormal_thyroid_physiology0.80959716
73MP0005386_behavior/neurological_phenoty0.80264936
74MP0004924_abnormal_behavior0.80264936
75MP0001502_abnormal_circadian_rhythm0.80205676
76MP0002078_abnormal_glucose_homeostasis0.80152258
77MP0009765_abnormal_xenobiotic_induced0.77981787
78MP0005670_abnormal_white_adipose0.77596327
79MP0009780_abnormal_chondrocyte_physiolo0.77310828
80MP0000566_synostosis0.77087297
81MP0003631_nervous_system_phenotype0.74910081
82MP0003122_maternal_imprinting0.74519458
83MP0002557_abnormal_social/conspecific_i0.74326053
84MP0005645_abnormal_hypothalamus_physiol0.73403388
85MP0002971_abnormal_brown_adipose0.70214524
86MP0005535_abnormal_body_temperature0.70041206
87MP0003329_amyloid_beta_deposits0.69068078
88MP0001661_extended_life_span0.68298211
89MP0005334_abnormal_fat_pad0.68283903
90MP0006276_abnormal_autonomic_nervous0.68237106
91MP0005266_abnormal_metabolism0.68201622
92MP0003690_abnormal_glial_cell0.67900129
93MP0004130_abnormal_muscle_cell0.66086764
94MP0005551_abnormal_eye_electrophysiolog0.65279256
95MP0002066_abnormal_motor_capabilities/c0.63611043
96MP0000639_abnormal_adrenal_gland0.62942525
97MP0010386_abnormal_urinary_bladder0.62819580
98MP0008569_lethality_at_weaning0.62269980
99MP0006035_abnormal_mitochondrial_morpho0.61508460
100MP0009053_abnormal_anal_canal0.61433858
101MP0005448_abnormal_energy_balance0.60932589
102MP0002822_catalepsy0.60210951
103MP0002067_abnormal_sensory_capabilities0.60159925
104MP0004811_abnormal_neuron_physiology0.59199121
105MP0001970_abnormal_pain_threshold0.58599554
106MP0008877_abnormal_DNA_methylation0.57715194
107MP0002733_abnormal_thermal_nociception0.57123952
108MP0001756_abnormal_urination0.56677801
109MP0010234_abnormal_vibrissa_follicle0.54877022
110MP0000920_abnormal_myelination0.54689969
111MP0003718_maternal_effect0.53413379
112MP0002132_abnormal_respiratory_system0.52926453
113MP0002638_abnormal_pupillary_reflex0.52639358
114MP0002249_abnormal_larynx_morphology0.52360559
115MP0002229_neurodegeneration0.51208984
116MP0003638_abnormal_response/metabolism_0.50511742
117MP0005395_other_phenotype0.48723573
118MP0008874_decreased_physiological_sensi0.48448852
119MP0008872_abnormal_physiological_respon0.44628447
120MP0008873_increased_physiological_sensi0.44032189
121MP0003953_abnormal_hormone_level0.43136995
122MP0002837_dystrophic_cardiac_calcinosis0.43098932
123MP0005464_abnormal_platelet_physiology0.41693508
124MP0002928_abnormal_bile_duct0.40788361
125MP0002136_abnormal_kidney_physiology0.39277650
126MP0009672_abnormal_birth_weight0.39146437
127MP0004782_abnormal_surfactant_physiolog0.39062745
128MP0003075_altered_response_to0.38077126
129MP0005248_abnormal_Harderian_gland0.37186677
130MP0000579_abnormal_nail_morphology0.35917582
131MP0005166_decreased_susceptibility_to0.34482649
132MP0005666_abnormal_adipose_tissue0.34477656
133MP0004381_abnormal_hair_follicle0.33365676
134MP0003436_decreased_susceptibility_to0.31772879
135MP0002796_impaired_skin_barrier0.31003105
136MP0002970_abnormal_white_adipose0.29803408
137MP0000230_abnormal_systemic_arterial0.29784273
138MP0001243_abnormal_dermal_layer0.28999052
139MP0003724_increased_susceptibility_to0.28914546
140MP0009115_abnormal_fat_cell0.28520543
141MP0002168_other_aberrant_phenotype0.27787445
142MP0004883_abnormal_blood_vessel0.27719795
143MP0009384_cardiac_valve_regurgitation0.26917214
144MP0000249_abnormal_blood_vessel0.26582300
145MP0001881_abnormal_mammary_gland0.25070545
146MP0006082_CNS_inflammation0.23656006
147MP0002090_abnormal_vision0.23511586
148MP0004264_abnormal_extraembryonic_tissu0.23017423
149MP0001845_abnormal_inflammatory_respons0.22681155
150MP0001853_heart_inflammation0.22348710
151MP0001944_abnormal_pancreas_morphology0.21988216
152MP0003959_abnormal_lean_body0.21849008

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.62168414
2Deep venous thrombosis (HP:0002625)7.41864388
3Intrahepatic cholestasis (HP:0001406)7.33791859
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.84106311
5Prolonged partial thromboplastin time (HP:0003645)6.55358771
6Hypobetalipoproteinemia (HP:0003563)6.47772231
7Xanthomatosis (HP:0000991)6.21309371
8Hyperlipoproteinemia (HP:0010980)5.59640147
9Complement deficiency (HP:0004431)5.32317538
10Hypolipoproteinemia (HP:0010981)4.78925841
11Joint hemorrhage (HP:0005261)4.73028204
12Hyperammonemia (HP:0001987)4.67956749
13Hyperglycinemia (HP:0002154)4.65972299
14Epidermoid cyst (HP:0200040)4.48456150
15Abnormality of methionine metabolism (HP:0010901)4.46793350
16Abnormality of the common coagulation pathway (HP:0010990)4.44564033
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.42808541
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.36801042
19Ketosis (HP:0001946)4.29336990
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.23856555
21Fat malabsorption (HP:0002630)4.23365326
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.20903267
23Hypoalphalipoproteinemia (HP:0003233)4.14057869
24Hyperglycinuria (HP:0003108)4.05479359
25Abnormality of glycine metabolism (HP:0010895)4.04907381
26Abnormality of serine family amino acid metabolism (HP:0010894)4.04907381
27Abnormality of pyrimidine metabolism (HP:0004353)4.00558949
28Abnormality of complement system (HP:0005339)3.86716368
29Abnormality of the intrinsic pathway (HP:0010989)3.83973126
30Hypoglycemic coma (HP:0001325)3.74467152
31Conjugated hyperbilirubinemia (HP:0002908)3.72264636
32Hypercholesterolemia (HP:0003124)3.58191552
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32903956
34Hyperbilirubinemia (HP:0002904)3.32041023
35Myokymia (HP:0002411)3.28182669
36Steatorrhea (HP:0002570)3.26166026
37Abnormality of fatty-acid metabolism (HP:0004359)3.25392141
38Abnormality of serum amino acid levels (HP:0003112)3.23849823
39Delayed CNS myelination (HP:0002188)3.14575337
40Abnormality of nucleobase metabolism (HP:0010932)3.10661561
41Neonatal hypoglycemia (HP:0001998)3.04883437
42Spontaneous abortion (HP:0005268)2.97668210
43Ketoacidosis (HP:0001993)2.97626771
44Hypochromic microcytic anemia (HP:0004840)2.95650589
45Myocardial infarction (HP:0001658)2.94119578
46Hepatocellular carcinoma (HP:0001402)2.93171563
47Skin nodule (HP:0200036)2.79578573
48Metabolic acidosis (HP:0001942)2.76705669
49Nephritis (HP:0000123)2.73532465
50Fair hair (HP:0002286)2.71579697
51Lethargy (HP:0001254)2.69433579
52Abnormality of purine metabolism (HP:0004352)2.65712867
53Systemic lupus erythematosus (HP:0002725)2.61977273
54Gout (HP:0001997)2.58389415
55Vascular calcification (HP:0004934)2.57431294
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55287511
57Dicarboxylic aciduria (HP:0003215)2.55287511
58Acanthocytosis (HP:0001927)2.54548742
59Spastic diplegia (HP:0001264)2.54319738
60Cerebral edema (HP:0002181)2.54274691
61Abnormal gallbladder morphology (HP:0012437)2.49076830
62Osteomalacia (HP:0002749)2.47270871
63Focal motor seizures (HP:0011153)2.42500745
64Cholelithiasis (HP:0001081)2.42483001
65Irritability (HP:0000737)2.41955372
66Hypoglycemic seizures (HP:0002173)2.41717461
67Mitral stenosis (HP:0001718)2.40471505
68Neonatal onset (HP:0003623)2.40253981
69Glomerulonephritis (HP:0000099)2.38162435
70Abnormal gallbladder physiology (HP:0012438)2.34319781
71Cholecystitis (HP:0001082)2.34319781
72Cardiovascular calcification (HP:0011915)2.26732146
73Malnutrition (HP:0004395)2.22836179
74Recurrent gram-negative bacterial infections (HP:0005420)2.21902432
75Epileptic encephalopathy (HP:0200134)2.19228970
76Amyloidosis (HP:0011034)2.19053457
77Focal seizures (HP:0007359)2.18671036
78Brushfield spots (HP:0001088)2.17436059
79Esophageal varix (HP:0002040)2.16045129
80Pancreatitis (HP:0001733)2.15380091
81Hyperphosphaturia (HP:0003109)2.14080670
82Epileptiform EEG discharges (HP:0011182)2.13270631
83Menorrhagia (HP:0000132)2.11253373
84Sensorimotor neuropathy (HP:0007141)2.09288090
85Gingival bleeding (HP:0000225)2.08052670
86Opisthotonus (HP:0002179)2.07246447
87Vomiting (HP:0002013)2.07155513
88Late onset (HP:0003584)2.06610045
89EEG with generalized epileptiform discharges (HP:0011198)2.06357273
90Enlarged kidneys (HP:0000105)2.04065543
91Hypsarrhythmia (HP:0002521)2.02002264
92Thrombophlebitis (HP:0004418)2.01621237
93Abnormality of the gallbladder (HP:0005264)2.01548466
94Febrile seizures (HP:0002373)2.00378341
95Poikilocytosis (HP:0004447)1.99827650
96Hyperinsulinemic hypoglycemia (HP:0000825)1.97849302
97Generalized hypopigmentation of hair (HP:0011358)1.97286281
98Status epilepticus (HP:0002133)1.94757608
99Atonic seizures (HP:0010819)1.94429933
100Hemorrhage of the eye (HP:0011885)1.93607413
101Generalized aminoaciduria (HP:0002909)1.91304658
102Rickets (HP:0002748)1.89664927
103Abnormal cartilage morphology (HP:0002763)1.88285273
104Hypophosphatemic rickets (HP:0004912)1.86155754
105Alkalosis (HP:0001948)1.85321111
106Abnormality of iron homeostasis (HP:0011031)1.85174605
107Abnormality of transition element cation homeostasis (HP:0011030)1.84156121
108Abnormality of proline metabolism (HP:0010907)1.81697306
109Hydroxyprolinuria (HP:0003080)1.81697306
110Abnormality of urine glucose concentration (HP:0011016)1.81591259
111Glycosuria (HP:0003076)1.81591259
112Torticollis (HP:0000473)1.79959751
113Bifid scrotum (HP:0000048)1.79787518
114Retinal atrophy (HP:0001105)1.78474719
115Renal cortical cysts (HP:0000803)1.77492242
116Reduced antithrombin III activity (HP:0001976)1.77443753
117Elevated hepatic transaminases (HP:0002910)1.77441054
118Abnormal enzyme/coenzyme activity (HP:0012379)1.77436997
119Hyperglycemia (HP:0003074)1.76267304
120Atrioventricular block (HP:0001678)1.75408638
121Pulmonary embolism (HP:0002204)1.75163550
122Abnormality of vitamin metabolism (HP:0100508)1.74991593
123Amblyopia (HP:0000646)1.74905177
124Acute hepatic failure (HP:0006554)1.74872807
125Generalized tonic-clonic seizures (HP:0002069)1.74690178
126Abnormal urine phosphate concentration (HP:0012599)1.71701314
127Hypothermia (HP:0002045)1.65929218
128Blue irides (HP:0000635)1.64432812
129Arthropathy (HP:0003040)1.64411584
130Focal dystonia (HP:0004373)1.64188508
131Delayed myelination (HP:0012448)1.63125723
132Abnormality of the Achilles tendon (HP:0005109)1.62216805
133Action tremor (HP:0002345)1.55558829
134Dyskinesia (HP:0100660)1.55303253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.73182128
2SIK14.57058031
3FGFR44.56522742
4NTRK34.33752361
5ERN14.20613638
6MAP3K93.72986067
7CASK3.09951123
8TAOK32.99968337
9INSRR2.98138141
10ERBB42.95374502
11MAP2K42.67606475
12MARK12.56044845
13PAK62.46096138
14PKN22.41045708
15MST1R1.96458815
16FLT31.96450884
17DAPK21.86176732
18MAPK111.85856415
19UHMK11.80699138
20ARAF1.79684339
21NTRK21.77521027
22TRIB31.76232544
23PLK21.69091786
24PIK3CG1.68097514
25MINK11.58972368
26LATS11.58912282
27TYK21.54342421
28ABL21.50730284
29PRKD31.47424162
30MAP4K21.45424023
31KSR21.43053489
32PTK61.41327535
33PAK31.37823864
34PINK11.36072556
35DAPK11.34168362
36FGFR21.33518717
37FRK1.32701371
38CDK51.30966549
39STK381.23869922
40NEK91.23031379
41MAP3K71.22145210
42JAK21.21208036
43PHKG11.18076514
44PHKG21.18076514
45KDR1.10702030
46CAMK2B1.07401391
47PRKAA21.03802870
48GRK61.03627377
49DYRK1A1.02779298
50GRK51.00606214
51STK38L1.00422168
52CAMK11.00037855
53PRKCZ0.98715087
54ERBB20.97968292
55CAMK1G0.97564833
56CAMKK20.96815749
57MAP2K30.95327350
58MAPK40.93548557
59MAPK130.92750866
60WNK30.92638526
61JAK10.90712174
62CDK150.88527503
63EPHA40.88325136
64TNK20.87084379
65MAP3K20.86802322
66CDK190.86015054
67TBK10.84974938
68MET0.84375010
69CDK180.82945127
70SGK10.82043273
71MAP3K100.81822439
72SIK20.81275116
73MAPK120.80972525
74CAMK2G0.80149346
75MAP3K140.79371282
76CDK60.78126290
77TSSK60.77829552
78CDK11A0.77328894
79PRKACG0.76261829
80STK110.74151687
81MAP2K60.74145237
82MAP3K110.73056192
83CDK140.72871839
84CAMK2A0.72666472
85MAPK150.71131924
86OXSR10.68457340
87NTRK10.67918295
88PRKAA10.67918043
89IRAK30.66575143
90PRKACA0.65167371
91MAP3K30.64826776
92SGK30.64477054
93GSK3A0.63997772
94RAF10.63789783
95PDPK10.62202215
96CSNK1E0.61518796
97CSNK1D0.61065745
98PRKCH0.59911435
99DYRK1B0.59867549
100NEK60.59389037
101MAPK70.58583496
102PRKCG0.57489732
103ALK0.56816189
104PRKG10.56730985
105CAMK1D0.56051191
106PRKCI0.55625496
107EPHB10.54645597
108TIE10.54540030
109AKT30.54514347
110BRAF0.54211442
111DYRK20.53965158
112CSK0.53604223
113MAP2K10.53027210
114ZAK0.52865668
115PTK20.52639319
116MAPK100.51286808
117CSNK1G10.50716319
118EPHA30.50383960
119PRKCE0.50366261
120CAMK2D0.49882353
121MAP3K50.48926573
122SGK20.48901631
123MAP2K70.48556157
124RET0.48211187
125PRPF4B0.47632160
126CDK40.47558775
127TAOK20.47363191
128RIPK10.46390255
129MAP3K40.46360374
130MAP3K130.46108298
131PRKCQ0.45409670
132PLK30.44881158
133LATS20.44429476
134CSNK1A10.43941943
135DAPK30.43307686
136PDK10.42265786
137PRKCB0.42240431
138FGFR30.41411735
139MAP2K20.40177530
140MAP3K60.39397867
141MTOR0.38883779
142CSNK1G20.38776182
143GRK10.38687771
144CSF1R0.38666492
145ICK0.38623126
146IGF1R0.38431221
147BRSK10.37944854
148SGK2230.37765922
149SGK4940.37765922
150CAMK40.34967257
151PKN10.33988341
152PDK30.33762421
153PDK40.33762421
154CSNK1G30.32958333
155IKBKE0.32749231
156IRAK20.32725414
157CAMKK10.32264682
158EGFR0.30250222
159PRKCA0.27685840
160TGFBR20.25596550
161MAP3K10.25044393
162CSNK1A1L0.24554670
163RPS6KA30.20988519

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53341699
2Nitrogen metabolism_Homo sapiens_hsa009103.70475021
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.57466123
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34337080
5* Arginine biosynthesis_Homo sapiens_hsa002202.99064851
6Complement and coagulation cascades_Homo sapiens_hsa046102.71535820
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68232520
8Tryptophan metabolism_Homo sapiens_hsa003802.67651707
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67453852
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61717954
11Fatty acid degradation_Homo sapiens_hsa000712.41224125
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37998656
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21659718
14Butanoate metabolism_Homo sapiens_hsa006502.11932137
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10469528
16Peroxisome_Homo sapiens_hsa041462.03678611
17Propanoate metabolism_Homo sapiens_hsa006401.92899347
18Chemical carcinogenesis_Homo sapiens_hsa052041.92733560
19Histidine metabolism_Homo sapiens_hsa003401.90830746
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90357262
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.89796670
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.79712071
23PPAR signaling pathway_Homo sapiens_hsa033201.79106951
24Fatty acid metabolism_Homo sapiens_hsa012121.73143968
25* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71533469
26beta-Alanine metabolism_Homo sapiens_hsa004101.70722215
27Staphylococcus aureus infection_Homo sapiens_hsa051501.68937262
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68420534
29Caffeine metabolism_Homo sapiens_hsa002321.68368881
30Retinol metabolism_Homo sapiens_hsa008301.67849676
31Selenocompound metabolism_Homo sapiens_hsa004501.62327693
32Phenylalanine metabolism_Homo sapiens_hsa003601.59796874
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59624262
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54342692
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52473075
36Bile secretion_Homo sapiens_hsa049761.48801943
37Tyrosine metabolism_Homo sapiens_hsa003501.45601741
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.44458175
39Pyruvate metabolism_Homo sapiens_hsa006201.37174479
40Sulfur metabolism_Homo sapiens_hsa009201.33911568
41Biosynthesis of amino acids_Homo sapiens_hsa012301.30929356
42Folate biosynthesis_Homo sapiens_hsa007901.28731549
43Starch and sucrose metabolism_Homo sapiens_hsa005001.26090652
44Fatty acid elongation_Homo sapiens_hsa000621.25530426
45Steroid biosynthesis_Homo sapiens_hsa001001.22917116
46Fat digestion and absorption_Homo sapiens_hsa049751.22833113
47ABC transporters_Homo sapiens_hsa020101.15487479
48Carbon metabolism_Homo sapiens_hsa012001.15288126
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10526767
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.08715936
51Vitamin B6 metabolism_Homo sapiens_hsa007501.06285625
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.01738012
53Arginine and proline metabolism_Homo sapiens_hsa003301.01169404
54Sulfur relay system_Homo sapiens_hsa041220.95334069
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93492411
56Vitamin digestion and absorption_Homo sapiens_hsa049770.86420827
57One carbon pool by folate_Homo sapiens_hsa006700.85673657
58Nicotine addiction_Homo sapiens_hsa050330.85187685
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84504549
60Synaptic vesicle cycle_Homo sapiens_hsa047210.84007836
61Lysine degradation_Homo sapiens_hsa003100.77621330
62Glycerolipid metabolism_Homo sapiens_hsa005610.71287007
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70575491
64Glutathione metabolism_Homo sapiens_hsa004800.63664686
65Pentose phosphate pathway_Homo sapiens_hsa000300.57657977
66* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56433030
67Fatty acid biosynthesis_Homo sapiens_hsa000610.50273360
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49851939
69* Metabolic pathways_Homo sapiens_hsa011000.47212983
70* GABAergic synapse_Homo sapiens_hsa047270.40896497
71Insulin secretion_Homo sapiens_hsa049110.40533489
72Amphetamine addiction_Homo sapiens_hsa050310.37973528
73Prion diseases_Homo sapiens_hsa050200.36716544
74Long-term potentiation_Homo sapiens_hsa047200.33991770
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33957478
76Serotonergic synapse_Homo sapiens_hsa047260.29204600
77* Glutamatergic synapse_Homo sapiens_hsa047240.27417155
78Fructose and mannose metabolism_Homo sapiens_hsa000510.27244485
79Galactose metabolism_Homo sapiens_hsa000520.24148916
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23748796
81Linoleic acid metabolism_Homo sapiens_hsa005910.21720053
82Insulin resistance_Homo sapiens_hsa049310.20772955
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.19828418
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19346015
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.18643948
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18142686
87Cocaine addiction_Homo sapiens_hsa050300.17295094
88Circadian entrainment_Homo sapiens_hsa047130.16288494
89Collecting duct acid secretion_Homo sapiens_hsa049660.15411767
90Dopaminergic synapse_Homo sapiens_hsa047280.12323833
91Morphine addiction_Homo sapiens_hsa050320.11398792
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.10430243
93Glucagon signaling pathway_Homo sapiens_hsa049220.10115459
94Circadian rhythm_Homo sapiens_hsa047100.10055748
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.07447393
96Mineral absorption_Homo sapiens_hsa049780.04019804
97Type II diabetes mellitus_Homo sapiens_hsa049300.03252251
98AMPK signaling pathway_Homo sapiens_hsa041520.01724771
99Ether lipid metabolism_Homo sapiens_hsa00565-0.2519281
100Protein digestion and absorption_Homo sapiens_hsa04974-0.2457590
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2328340
102Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2280151
103Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2254266
104Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2217580
105Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2174066
106Hepatitis C_Homo sapiens_hsa05160-0.2051906
107Renin-angiotensin system_Homo sapiens_hsa04614-0.1921312
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1899734
109Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1848304
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1739506
111African trypanosomiasis_Homo sapiens_hsa05143-0.1696356
112Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1676981
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1656645
114Insulin signaling pathway_Homo sapiens_hsa04910-0.0977110
115Regulation of autophagy_Homo sapiens_hsa04140-0.0877533
116Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0848249
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0558686
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0556675
119Salivary secretion_Homo sapiens_hsa04970-0.0437462
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0420876
121Vibrio cholerae infection_Homo sapiens_hsa05110-0.0415998
122Pertussis_Homo sapiens_hsa05133-0.0274913
123Taste transduction_Homo sapiens_hsa04742-0.0253663
124Oocyte meiosis_Homo sapiens_hsa04114-0.0206498

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