GLT1D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.71030488
2L-phenylalanine catabolic process (GO:0006559)7.71030488
3L-phenylalanine metabolic process (GO:0006558)7.39680780
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.39680780
5aromatic amino acid family catabolic process (GO:0009074)6.91676329
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.51931387
7positive regulation by organism of defense response of other organism involved in symbiotic interact6.51931387
8modulation by symbiont of host immune response (GO:0052553)6.51931387
9positive regulation by symbiont of host defense response (GO:0052509)6.51931387
10modulation by symbiont of host defense response (GO:0052031)6.51931387
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.51931387
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.45401722
13negative regulation of cell killing (GO:0031342)6.45401722
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.38812657
15indole-containing compound catabolic process (GO:0042436)6.20888637
16indolalkylamine catabolic process (GO:0046218)6.20888637
17tryptophan catabolic process (GO:0006569)6.20888637
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.15678264
19kynurenine metabolic process (GO:0070189)6.12356907
20urea metabolic process (GO:0019627)5.86882910
21urea cycle (GO:0000050)5.86882910
22bile acid biosynthetic process (GO:0006699)5.85150952
23tryptophan metabolic process (GO:0006568)5.82070203
24positive regulation of gamma-delta T cell activation (GO:0046645)5.74096698
25sulfur amino acid catabolic process (GO:0000098)5.54850977
26high-density lipoprotein particle remodeling (GO:0034375)5.52796054
27glyoxylate metabolic process (GO:0046487)5.52173718
28serine family amino acid catabolic process (GO:0009071)5.49401459
29detection of other organism (GO:0098543)5.47049091
30macrophage activation involved in immune response (GO:0002281)5.45637963
31nitrogen cycle metabolic process (GO:0071941)5.39084416
32neutrophil activation involved in immune response (GO:0002283)5.35327499
33negative regulation of fibrinolysis (GO:0051918)5.34615228
34alpha-linolenic acid metabolic process (GO:0036109)5.34537384
35detection of molecule of bacterial origin (GO:0032490)5.32432170
36cysteine metabolic process (GO:0006534)5.29028065
37regulation of fibrinolysis (GO:0051917)5.15342487
38bile acid metabolic process (GO:0008206)5.14890060
39protein carboxylation (GO:0018214)5.09071316
40peptidyl-glutamic acid carboxylation (GO:0017187)5.09071316
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.08999814
42detection of bacterium (GO:0016045)5.06673312
43regulation of B cell receptor signaling pathway (GO:0050855)5.05430398
44antigen processing and presentation of endogenous antigen (GO:0019883)5.01665456
45aromatic amino acid family metabolic process (GO:0009072)5.00886022
46homocysteine metabolic process (GO:0050667)5.00388531
47response to peptidoglycan (GO:0032494)4.95197247
48detection of external biotic stimulus (GO:0098581)4.94266423
49complement activation, alternative pathway (GO:0006957)4.93975591
50leukocyte migration involved in inflammatory response (GO:0002523)4.93404763
51regulation of protein activation cascade (GO:2000257)4.90000659
52positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.89340853
53alpha-amino acid catabolic process (GO:1901606)4.85831128
54tyrosine metabolic process (GO:0006570)4.83845925
55cellular extravasation (GO:0045123)4.82646406
56glycine metabolic process (GO:0006544)4.69860928
57negative regulation of cholesterol transport (GO:0032375)4.69717599
58negative regulation of sterol transport (GO:0032372)4.69717599
59fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.69543011
60amino-acid betaine metabolic process (GO:0006577)4.69456857
61reverse cholesterol transport (GO:0043691)4.68486867
62regulation of cholesterol esterification (GO:0010872)4.68285918
63leukocyte aggregation (GO:0070486)4.67503739
64regulation of triglyceride catabolic process (GO:0010896)4.64563565
65lysine catabolic process (GO:0006554)4.63442848
66lysine metabolic process (GO:0006553)4.63442848
67regulation of interferon-beta biosynthetic process (GO:0045357)4.61990514
68imidazole-containing compound metabolic process (GO:0052803)4.61206353
69protein-lipid complex remodeling (GO:0034368)4.61046180
70macromolecular complex remodeling (GO:0034367)4.61046180
71plasma lipoprotein particle remodeling (GO:0034369)4.61046180
72coenzyme catabolic process (GO:0009109)4.58615828
73triglyceride homeostasis (GO:0070328)4.57969745
74acylglycerol homeostasis (GO:0055090)4.57969745
75microglial cell activation (GO:0001774)4.55413743
76regulation of complement activation (GO:0030449)4.54806186
77glutamate metabolic process (GO:0006536)4.54343174
78negative regulation of lymphocyte mediated immunity (GO:0002707)4.53114404
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.50573545
80cellular amino acid catabolic process (GO:0009063)4.48606746
81response to host immune response (GO:0052572)4.47631705
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.47631705
83negative regulation of interleukin-12 production (GO:0032695)4.44781260
84drug catabolic process (GO:0042737)4.40599932
85neutrophil activation (GO:0042119)4.39846357
86dicarboxylic acid biosynthetic process (GO:0043650)4.38161672
87respiratory burst (GO:0045730)4.36662877
88serine family amino acid metabolic process (GO:0009069)4.36656953
89indolalkylamine metabolic process (GO:0006586)4.36316747
90detection of biotic stimulus (GO:0009595)4.35380371
91cellular modified amino acid catabolic process (GO:0042219)4.31731115
92bile acid and bile salt transport (GO:0015721)4.31226618
93phospholipid efflux (GO:0033700)4.30927657
94regulation of gamma-delta T cell activation (GO:0046643)4.23384135
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22182632
96cellular biogenic amine catabolic process (GO:0042402)4.21295154
97amine catabolic process (GO:0009310)4.21295154
98macrophage activation (GO:0042116)4.17700223
99cellular ketone body metabolic process (GO:0046950)4.17381965
100response to interleukin-15 (GO:0070672)4.16474457
101benzene-containing compound metabolic process (GO:0042537)4.16165691
102serine family amino acid biosynthetic process (GO:0009070)4.15113806
103neutrophil mediated immunity (GO:0002446)4.11031036
104cellular glucuronidation (GO:0052695)4.10277271
105response to host (GO:0075136)4.08685855
106response to host defenses (GO:0052200)4.08685855
107response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.08685855
108plasma lipoprotein particle clearance (GO:0034381)4.07985389
109cholesterol efflux (GO:0033344)4.07478378
110regulation of bile acid biosynthetic process (GO:0070857)3.95748380
111exogenous drug catabolic process (GO:0042738)3.94499134
112arginine metabolic process (GO:0006525)3.94180032
113myeloid cell activation involved in immune response (GO:0002275)3.92936183
114granulocyte activation (GO:0036230)3.92581975
115negative regulation of leukocyte mediated immunity (GO:0002704)3.92152466
116negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.84857926
117cellular response to interleukin-15 (GO:0071350)3.80420536
118low-density lipoprotein particle remodeling (GO:0034374)3.79698119
119production of molecular mediator involved in inflammatory response (GO:0002532)3.79617185
120organic acid catabolic process (GO:0016054)3.78041852
121carboxylic acid catabolic process (GO:0046395)3.78041852
122negative regulation of T cell mediated immunity (GO:0002710)3.77461223
123regulation of mast cell degranulation (GO:0043304)3.76498576
124positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.75316554
125ethanol oxidation (GO:0006069)3.75208889
126cofactor catabolic process (GO:0051187)3.74530361
127aspartate family amino acid catabolic process (GO:0009068)3.73843260
128regulation of cholesterol homeostasis (GO:2000188)3.69765220
129plasma lipoprotein particle assembly (GO:0034377)3.69625276
130short-chain fatty acid metabolic process (GO:0046459)3.67744098
131drug metabolic process (GO:0017144)3.67409918
132immunoglobulin mediated immune response (GO:0016064)3.67341779
133negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.64797480
134negative regulation of lipase activity (GO:0060192)3.63458377
135aldehyde catabolic process (GO:0046185)3.62731113
136regulation of gamma-delta T cell differentiation (GO:0045586)3.62594055
137intestinal cholesterol absorption (GO:0030299)3.61875347
138positive regulation of mast cell activation (GO:0033005)3.61029051
139positive regulation of lipid catabolic process (GO:0050996)3.60296673
140fibrinolysis (GO:0042730)3.60216471
141ketone body metabolic process (GO:1902224)3.59692444
142cholesterol homeostasis (GO:0042632)3.59662541
143NAD biosynthetic process (GO:0009435)3.57022588
144myeloid leukocyte mediated immunity (GO:0002444)3.56688336
145very-low-density lipoprotein particle assembly (GO:0034379)3.55694194
146acetyl-CoA metabolic process (GO:0006084)3.55286943
147regulation of myeloid leukocyte mediated immunity (GO:0002886)3.54234726
148flavonoid metabolic process (GO:0009812)3.53849854
149sterol homeostasis (GO:0055092)3.53835398
150glucuronate metabolic process (GO:0019585)3.53727485
151uronic acid metabolic process (GO:0006063)3.53727485
152epoxygenase P450 pathway (GO:0019373)3.53184331
153positive regulation of triglyceride lipase activity (GO:0061365)3.50970567
154positive regulation of lipoprotein lipase activity (GO:0051006)3.50970567
155cytolysis (GO:0019835)3.50146004
156phospholipid homeostasis (GO:0055091)3.49884171
157regulation of mast cell activation involved in immune response (GO:0033006)3.49560690
158blood coagulation, intrinsic pathway (GO:0007597)3.48572754
159antigen processing and presentation via MHC class Ib (GO:0002475)3.44300048
160B cell receptor signaling pathway (GO:0050853)3.41807561
161regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.37834343
162type I interferon signaling pathway (GO:0060337)3.37392178
163cellular response to type I interferon (GO:0071357)3.37392178
164regulation of T-helper 2 cell differentiation (GO:0045628)3.36649997
165leukocyte degranulation (GO:0043299)3.35249247
166regulation of mast cell activation (GO:0033003)3.34385044
167response to type I interferon (GO:0034340)3.33824809
168regulation of leukocyte degranulation (GO:0043300)3.32053173
169response to muramyl dipeptide (GO:0032495)3.24155389
170regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.22679759
171germinal center formation (GO:0002467)3.21746613
172regulation of regulated secretory pathway (GO:1903305)3.12841682
173defense response to protozoan (GO:0042832)3.12770255
174positive regulation of cellular amide metabolic process (GO:0034250)3.11658459
175negative regulation of type 2 immune response (GO:0002829)3.07879177
176positive regulation of mast cell activation involved in immune response (GO:0033008)3.05226602
177positive regulation of mast cell degranulation (GO:0043306)3.05226602
178regulation of tolerance induction (GO:0002643)3.04896222
179lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03769654
180regulation of B cell differentiation (GO:0045577)3.02751304
181negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.02253747
182regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.00782046
183dendritic cell migration (GO:0036336)3.00170893
184negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99598220
185negative regulation of T-helper cell differentiation (GO:0045623)2.99598220
186neutrophil chemotaxis (GO:0030593)2.99566115
187interferon-gamma-mediated signaling pathway (GO:0060333)2.99023464
188negative regulation of immunoglobulin mediated immune response (GO:0002890)2.97181514
189negative regulation of B cell mediated immunity (GO:0002713)2.97181514
190myeloid leukocyte activation (GO:0002274)2.97120277
191negative regulation of erythrocyte differentiation (GO:0045647)2.96797079
192positive regulation of interferon-alpha production (GO:0032727)2.96564946
193regulation of T cell tolerance induction (GO:0002664)2.94215948
194neutrophil migration (GO:1990266)2.91721733
195negative regulation of phagocytosis (GO:0050765)2.90747337
196positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.89208511
197negative regulation of interleukin-6 production (GO:0032715)2.88018686
198negative regulation of toll-like receptor signaling pathway (GO:0034122)2.87118103
199dendritic cell chemotaxis (GO:0002407)2.86819211
200regulation of T cell mediated cytotoxicity (GO:0001914)2.86459760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.08183806
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.88575661
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.52433195
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.22887107
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.15813430
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.95457219
7BP1_19119308_ChIP-ChIP_Hs578T_Human4.75788718
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.70853791
9IRF8_21731497_ChIP-ChIP_J774_Mouse4.16800025
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.89048851
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.87438432
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.68926419
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.66806276
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.61850951
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20911534
16IRF8_27001747_Chip-Seq_BMDM_Mouse3.18624957
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18385309
18RUNX_20019798_ChIP-Seq_JUKART_Human2.76947766
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73756375
20SPI1_23127762_ChIP-Seq_K562_Human2.72297015
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70126957
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60205172
23SPI1_23547873_ChIP-Seq_NB4_Human2.60148601
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55595544
25VDR_24763502_ChIP-Seq_THP-1_Human2.55489116
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48854213
27VDR_21846776_ChIP-Seq_THP-1_Human2.47034435
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34372914
29MAF_26560356_Chip-Seq_TH1_Human2.23237962
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21197041
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20558257
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18388141
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14184598
34MYB_26560356_Chip-Seq_TH2_Human2.14063632
35SCL_19346495_ChIP-Seq_HPC-7_Human2.11236387
36RUNX1_22412390_ChIP-Seq_EML_Mouse2.10903910
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05509339
38BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03014142
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3743131
40UTX_26944678_Chip-Seq_JUKART_Human1.98685571
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98301340
42TCF7_22412390_ChIP-Seq_EML_Mouse1.95592574
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91589733
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91326319
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.90248527
46VDR_24787735_ChIP-Seq_THP-1_Human1.86131068
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86044214
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83782525
49MYB_26560356_Chip-Seq_TH1_Human1.83607039
50MYC_22102868_ChIP-Seq_BL_Human1.74222939
51KDM2B_26808549_Chip-Seq_DND41_Human1.72570329
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71979669
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.65924425
54GATA3_27048872_Chip-Seq_THYMUS_Human1.64329376
55MAF_26560356_Chip-Seq_TH2_Human1.62219843
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.60501147
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59458612
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.57109231
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55976497
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53892197
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53787097
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53168214
63HTT_18923047_ChIP-ChIP_STHdh_Human1.52278038
64RXRA_24833708_ChIP-Seq_LIVER_Mouse1.50360591
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49901361
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49173254
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49034316
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48902572
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44499944
70* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44465328
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40721877
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39300488
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39011120
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38377349
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37348203
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35377268
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35310668
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32674050
79PU_27001747_Chip-Seq_BMDM_Mouse1.31427464
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29787721
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29741577
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26882316
83GATA3_26560356_Chip-Seq_TH2_Human1.26028652
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25369469
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25344504
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23037522
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22459126
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22442675
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.22243009
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19209506
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18874518
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16918020
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16790690
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16707461
95GATA1_19941826_ChIP-Seq_K562_Human1.16446413
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15435346
97NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14843865
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12306618
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12153701
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.07985969
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07634555
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06211394
103BCL6_27268052_Chip-Seq_Bcells_Human1.04682433
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04623503
105DROSHA_22980978_ChIP-Seq_HELA_Human1.01023732
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00447613
107ELK3_25401928_ChIP-Seq_HUVEC_Human1.00340331
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.00014611
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99570917
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99090885
111* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98499072
112GATA2_19941826_ChIP-Seq_K562_Human0.97063941
113KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96330279
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.92982975
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92491363
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91429305
117SPI1_20517297_ChIP-Seq_HL60_Human0.91091870
118GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90941703
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88755328
120RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88734237
121KDM2B_26808549_Chip-Seq_K562_Human0.88352490
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87867265
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87834383
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86710570
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85251427
126SMRT_27268052_Chip-Seq_Bcells_Human0.84065146
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83969886
128RARB_24833708_ChIP-Seq_LIVER_Mouse0.82486274
129CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82234425
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81680914
131SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81245670
132ZNF263_19887448_ChIP-Seq_K562_Human0.80495913
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80194258
134POU5F1_16518401_ChIP-PET_MESCs_Mouse0.77534712
135KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.77289755
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76323338
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73724537
138NANOG_16518401_ChIP-PET_MESCs_Mouse0.72259773
139* REST_21632747_ChIP-Seq_MESCs_Mouse0.70853668
140LXR_22292898_ChIP-Seq_THP-1_Human0.69726951
141SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68229385
142MYC_27129775_Chip-Seq_CORNEA_Mouse0.67641976
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.67416020
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.66435503
145* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.66297792
146* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.65699720
147MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.65272251
148SPI1_26923725_Chip-Seq_HPCs_Mouse0.65182568
149LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.64288723
150CLOCK_20551151_ChIP-Seq_293T_Human0.63910153
151MYC_19915707_ChIP-ChIP_AK7_Human0.63675482
152TET1_21451524_ChIP-Seq_MESCs_Mouse0.62814820
153P53_21459846_ChIP-Seq_SAOS-2_Human0.62419871
154CTCF_27219007_Chip-Seq_Bcells_Human0.61558633
155* REST_18959480_ChIP-ChIP_MESCs_Mouse0.60781884
156STAT1_17558387_ChIP-Seq_HELA_Human0.60443092
157FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58986863
158GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.58775245
159* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.58701924
160BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58192694
161EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.57443617
162SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.57285565
163E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.56895651
164ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.55710367
165AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.55049875
166BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.53403404
167* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.53337853
168IRF1_19129219_ChIP-ChIP_H3396_Human0.53300347
169FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52508357
170* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.52410349
171SOX2_22085726_ChIP-Seq_NPCs_Mouse0.51881002
172* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.50191669
173GATA4_25053715_ChIP-Seq_YYC3_Human0.49922991
174KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.49766009
175KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.49766009
176KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.49766009
177SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.49703691
178* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48916307
179FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.47940768
180SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.47618343
181CBP_21632823_ChIP-Seq_H3396_Human0.46880236
182SOX2_21211035_ChIP-Seq_LN229_Human0.46607746
183TAF15_26573619_Chip-Seq_HEK293_Human0.46561424
184GATA1_22025678_ChIP-Seq_K562_Human0.46428526
185SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45672903
186NCOR_22424771_ChIP-Seq_293T_Human0.45478599
187CEBPB_22108803_ChIP-Seq_LS180_Human0.45315176
188FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.44557090
189CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.44067982
190SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.43873660
191* KLF4_19829295_ChIP-Seq_ESCs_Human0.43656588
192EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.43328192
193BCOR_27268052_Chip-Seq_Bcells_Human0.43252723
194GATA3_21867929_ChIP-Seq_CD8_Mouse0.43218455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.29324147
2MP0005360_urolithiasis7.42546033
3MP0005085_abnormal_gallbladder_physiolo6.64854325
4MP0005365_abnormal_bile_salt6.25769155
5MP0003724_increased_susceptibility_to5.55808282
6MP0008875_abnormal_xenobiotic_pharmacok5.36615703
7MP0003806_abnormal_nucleotide_metabolis4.44068029
8MP0003436_decreased_susceptibility_to4.27261863
9MP0003303_peritoneal_inflammation4.00961041
10MP0003252_abnormal_bile_duct3.78228724
11MP0001835_abnormal_antigen_presentation3.65510679
12MP0010329_abnormal_lipoprotein_level3.50373969
13MP0002419_abnormal_innate_immunity3.26212650
14MP0005083_abnormal_biliary_tract2.98265712
15MP0005025_abnormal_response_to2.89923212
16MP0009785_altered_susceptibility_to2.86716857
17MP0009840_abnormal_foam_cell2.84732880
18MP0003195_calcinosis2.84332509
19MP0001800_abnormal_humoral_immune2.83864203
20MP0005332_abnormal_amino_acid2.79271265
21MP0000685_abnormal_immune_system2.74573116
22MP0005000_abnormal_immune_tolerance2.72807357
23MP0005671_abnormal_response_to2.69622967
24MP0001790_abnormal_immune_system2.64042807
25MP0005387_immune_system_phenotype2.64042807
26MP0001666_abnormal_nutrient_absorption2.56044818
27MP0002723_abnormal_immune_serum2.55451669
28MP0006082_CNS_inflammation2.50888690
29MP0008260_abnormal_autophagy2.48819254
30MP0002420_abnormal_adaptive_immunity2.48307015
31MP0001819_abnormal_immune_cell2.45506435
32MP0002452_abnormal_antigen_presenting2.41185592
33MP0004019_abnormal_vitamin_homeostasis2.23162413
34MP0003300_gastrointestinal_ulcer2.18092461
35MP0002132_abnormal_respiratory_system2.16902989
36MP0001533_abnormal_skeleton_physiology2.15136601
37MP0003868_abnormal_feces_composition2.06512920
38MP0002118_abnormal_lipid_homeostasis2.05070395
39MP0002148_abnormal_hypersensitivity_rea2.01523533
40MP0000609_abnormal_liver_physiology2.00347392
41MP0005464_abnormal_platelet_physiology1.99312724
42MP0003828_pulmonary_edema1.91128932
43MP0002405_respiratory_system_inflammati1.90546788
44MP0003172_abnormal_lysosome_physiology1.87618163
45MP0002398_abnormal_bone_marrow1.83982068
46MP0000716_abnormal_immune_system1.81765096
47MP0003191_abnormal_cellular_cholesterol1.80671402
48MP0001764_abnormal_homeostasis1.77375978
49MP0003763_abnormal_thymus_physiology1.76175342
50MP0005319_abnormal_enzyme/_coenzyme1.72920991
51MP0001845_abnormal_inflammatory_respons1.68089075
52MP0009278_abnormal_bone_marrow1.66041839
53MP0003183_abnormal_peptide_metabolism1.64899247
54MP0002138_abnormal_hepatobiliary_system1.58536109
55MP0002277_abnormal_respiratory_mucosa1.56507537
56MP0004947_skin_inflammation1.52899936
57MP0004883_abnormal_blood_vessel1.52767011
58MP0010155_abnormal_intestine_physiology1.52471348
59MP0003866_abnormal_defecation1.50304850
60MP0004381_abnormal_hair_follicle1.49473317
61MP0002722_abnormal_immune_system1.49315739
62MP0000689_abnormal_spleen_morphology1.48179811
63MP0005584_abnormal_enzyme/coenzyme_acti1.46191343
64MP0000465_gastrointestinal_hemorrhage1.46040257
65MP0005410_abnormal_fertilization1.45273029
66MP0005310_abnormal_salivary_gland1.41789485
67MP0004510_myositis1.39972582
68MP0002429_abnormal_blood_cell1.39479940
69MP0002396_abnormal_hematopoietic_system1.38910572
70MP0009697_abnormal_copulation1.38393116
71MP0002822_catalepsy1.32417773
72MP0000703_abnormal_thymus_morphology1.32204917
73MP0001851_eye_inflammation1.23296753
74MP0000858_altered_metastatic_potential1.19781509
75MP0001545_abnormal_hematopoietic_system1.19485300
76MP0005397_hematopoietic_system_phenotyp1.19485300
77MP0009333_abnormal_splenocyte_physiolog1.19266846
78MP0003011_delayed_dark_adaptation1.18620623
79MP0005451_abnormal_body_composition1.18114334
80MP0005647_abnormal_sex_gland1.18029693
81MP0005164_abnormal_response_to1.15626652
82MP0002998_abnormal_bone_remodeling1.11151407
83MP0005166_decreased_susceptibility_to1.06976835
84MP0000598_abnormal_liver_morphology1.06504712
85MP0009643_abnormal_urine_homeostasis1.05736105
86MP0005670_abnormal_white_adipose1.02125742
87MP0003186_abnormal_redox_activity1.00944590
88MP0000569_abnormal_digit_pigmentation1.00137843
89MP0000604_amyloidosis0.92816170
90MP0003705_abnormal_hypodermis_morpholog0.92043236
91MP0003656_abnormal_erythrocyte_physiolo0.91712755
92MP0003787_abnormal_imprinting0.89684348
93MP0002078_abnormal_glucose_homeostasis0.88933827
94MP0006036_abnormal_mitochondrial_physio0.88424422
95MP0002166_altered_tumor_susceptibility0.88130764
96MP0008004_abnormal_stomach_pH0.87142297
97MP0002254_reproductive_system_inflammat0.84884511
98MP0005266_abnormal_metabolism0.84684217
99MP0003878_abnormal_ear_physiology0.84476421
100MP0005377_hearing/vestibular/ear_phenot0.84476421
101MP0003045_fibrosis0.83734583
102MP0002876_abnormal_thyroid_physiology0.81250312
103MP0005376_homeostasis/metabolism_phenot0.80859999
104MP0005636_abnormal_mineral_homeostasis0.80844802
105MP0005535_abnormal_body_temperature0.80635105
106MP0009642_abnormal_blood_homeostasis0.79863259
107MP0003329_amyloid_beta_deposits0.78687006
108MP0009763_increased_sensitivity_to0.77722639
109MP0001986_abnormal_taste_sensitivity0.77698689
110MP0003448_altered_tumor_morphology0.76871959
111MP0003221_abnormal_cardiomyocyte_apopto0.76050907
112MP0005390_skeleton_phenotype0.75197667
113MP0006035_abnormal_mitochondrial_morpho0.75041481
114MP0008872_abnormal_physiological_respon0.74001479
115MP0005075_abnormal_melanosome_morpholog0.73787731
116MP0000015_abnormal_ear_pigmentation0.71842655
117MP0001663_abnormal_digestive_system0.71731702
118MP0000639_abnormal_adrenal_gland0.71639628
119MP0004264_abnormal_extraembryonic_tissu0.71281613
120MP0000343_altered_response_to0.71143803
121MP0009764_decreased_sensitivity_to0.70155624
122MP0009765_abnormal_xenobiotic_induced0.70063520
123MP0002332_abnormal_exercise_endurance0.69925451
124MP0005220_abnormal_exocrine_pancreas0.66078749
125MP0008874_decreased_physiological_sensi0.65803840
126MP0000920_abnormal_myelination0.64504045
127MP0004484_altered_response_of0.63242329
128MP0002971_abnormal_brown_adipose0.62456956
129MP0005334_abnormal_fat_pad0.61892706
130MP0009053_abnormal_anal_canal0.60885096
131MP0005448_abnormal_energy_balance0.60006675
132MP0005058_abnormal_lysosome_morphology0.58401479
133MP0003690_abnormal_glial_cell0.57942717
134MP0003718_maternal_effect0.57819091
135MP0005388_respiratory_system_phenotype0.57746318
136MP0002133_abnormal_respiratory_system0.57746318
137MP0005248_abnormal_Harderian_gland0.57319611
138MP0001853_heart_inflammation0.56790475
139MP0003890_abnormal_embryonic-extraembry0.56725651
140MP0003879_abnormal_hair_cell0.56286690
141MP0004130_abnormal_muscle_cell0.56069606
142MP0005408_hypopigmentation0.55907384
143MP0003953_abnormal_hormone_level0.54981303
144MP0008469_abnormal_protein_level0.54276916
145MP0001661_extended_life_span0.54239525
146MP0000249_abnormal_blood_vessel0.54185548
147MP0004808_abnormal_hematopoietic_stem0.53941262
148MP0009672_abnormal_birth_weight0.53252360
149MP0005084_abnormal_gallbladder_morpholo0.51247567
150MP0003698_abnormal_male_reproductive0.50236677
151MP0001756_abnormal_urination0.49467737
152MP0004043_abnormal_pH_regulation0.47448484
153MP0003638_abnormal_response/metabolism_0.45750564
154MP0005395_other_phenotype0.44691920
155MP0003075_altered_response_to0.44630599
156MP0008873_increased_physiological_sensi0.43696334
157MP0010234_abnormal_vibrissa_follicle0.42442521
158MP0001929_abnormal_gametogenesis0.41363358
159MP0000579_abnormal_nail_morphology0.40961369
160MP0002161_abnormal_fertility/fecundity0.38993306
161MP0002928_abnormal_bile_duct0.38733577
162MP0002909_abnormal_adrenal_gland0.37539817
163MP0008961_abnormal_basal_metabolism0.35986957
164MP0005666_abnormal_adipose_tissue0.35168731
165MP0002069_abnormal_eating/drinking_beha0.34348768
166MP0003633_abnormal_nervous_system0.33144810
167MP0002837_dystrophic_cardiac_calcinosis0.31933039
168MP0002269_muscular_atrophy0.31903434
169MP0005646_abnormal_pituitary_gland0.31486430
170MP0010368_abnormal_lymphatic_system0.31377029
171MP0001944_abnormal_pancreas_morphology0.30491056
172MP0005167_abnormal_blood-brain_barrier0.29865944
173MP0004133_heterotaxia0.29411757
174MP0002970_abnormal_white_adipose0.29123986
175MP0003632_abnormal_nervous_system0.28708383
176MP0002796_impaired_skin_barrier0.28284983
177MP0003699_abnormal_female_reproductive0.27573786
178MP0004859_abnormal_synaptic_plasticity0.26935680
179MP0005187_abnormal_penis_morphology0.26829653
180MP0003631_nervous_system_phenotype0.26713883

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.56484095
2Intrahepatic cholestasis (HP:0001406)7.30428377
3Deep venous thrombosis (HP:0002625)7.05992783
4Abnormality of monocarboxylic acid metabolism (HP:0010996)7.00852151
5Eczematoid dermatitis (HP:0000976)6.96852050
6Hypobetalipoproteinemia (HP:0003563)6.51487443
7Recurrent abscess formation (HP:0002722)6.31887915
8Prolonged partial thromboplastin time (HP:0003645)6.31524013
9Recurrent bacterial skin infections (HP:0005406)6.27485242
10Myositis (HP:0100614)6.10872370
11Orchitis (HP:0100796)5.98339066
12Xanthomatosis (HP:0000991)5.91514406
13Retrobulbar optic neuritis (HP:0100654)5.73263322
14Optic neuritis (HP:0100653)5.73263322
15Abnormality of macrophages (HP:0004311)5.45344155
16Hyperlipoproteinemia (HP:0010980)5.28578958
17Stomatitis (HP:0010280)4.98552430
18Complement deficiency (HP:0004431)4.75248735
19Hyperglycinemia (HP:0002154)4.70821678
20Hypolipoproteinemia (HP:0010981)4.69065420
21Gastrointestinal infarctions (HP:0005244)4.63234160
22Hyperammonemia (HP:0001987)4.57526544
23Elevated erythrocyte sedimentation rate (HP:0003565)4.54913292
24Epidermoid cyst (HP:0200040)4.49512529
25Abnormality of methionine metabolism (HP:0010901)4.47247887
26Joint hemorrhage (HP:0005261)4.46973009
27Abnormality of sulfur amino acid metabolism (HP:0004339)4.45846468
28Ketosis (HP:0001946)4.39613959
29Abnormality of pyrimidine metabolism (HP:0004353)4.29659229
30Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22812695
31Obstructive lung disease (HP:0006536)4.19116433
32Chronic obstructive pulmonary disease (HP:0006510)4.19116433
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.17649158
34Recurrent fungal infections (HP:0002841)4.15771958
35Keratoconjunctivitis sicca (HP:0001097)4.15158038
36Hyperglycinuria (HP:0003108)4.11388420
37Mediastinal lymphadenopathy (HP:0100721)4.08852594
38Abnormality of glutamine family amino acid metabolism (HP:0010902)4.06624003
39Recurrent skin infections (HP:0001581)4.06196300
40Abnormality of the common coagulation pathway (HP:0010990)4.03196160
41Meningitis (HP:0001287)4.02888419
42Abnormality of serine family amino acid metabolism (HP:0010894)3.99528248
43Abnormality of glycine metabolism (HP:0010895)3.99528248
44Fat malabsorption (HP:0002630)3.98306813
45Hypoalphalipoproteinemia (HP:0003233)3.98278058
46Gingivitis (HP:0000230)3.86874569
47Keratoconjunctivitis (HP:0001096)3.83028856
48Abnormal delayed hypersensitivity skin test (HP:0002963)3.82810830
49Encephalitis (HP:0002383)3.78026605
50Abnormality of the intrinsic pathway (HP:0010989)3.72305868
51Hypercholesterolemia (HP:0003124)3.66027039
52Conjugated hyperbilirubinemia (HP:0002908)3.64051771
53Urticaria (HP:0001025)3.62438239
54Spontaneous hematomas (HP:0007420)3.59784103
55Hypoglycemic coma (HP:0001325)3.54687528
56Hypochromic anemia (HP:0001931)3.49650189
57Chronic mucocutaneous candidiasis (HP:0002728)3.49317098
58Recurrent cutaneous fungal infections (HP:0011370)3.49317098
59Vasculitis (HP:0002633)3.48400986
60Abnormality of complement system (HP:0005339)3.45349326
61Increased IgE level (HP:0003212)3.43506995
62Peritonitis (HP:0002586)3.42718861
63Episodic fever (HP:0001954)3.39572284
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.33025525
65Chest pain (HP:0100749)3.30354505
66Delayed CNS myelination (HP:0002188)3.27824667
67Prolonged bleeding time (HP:0003010)3.27056508
68Gingival bleeding (HP:0000225)3.26054909
69Cellulitis (HP:0100658)3.21602726
70Hyperbilirubinemia (HP:0002904)3.20638820
71Abnormality of nucleobase metabolism (HP:0010932)3.19997657
72Hypochromic microcytic anemia (HP:0004840)3.15285659
73Ketoacidosis (HP:0001993)3.13473149
74Abnormality of serum amino acid levels (HP:0003112)3.11767249
75Arterial thrombosis (HP:0004420)3.07941725
76Hemoptysis (HP:0002105)3.05407406
77Steatorrhea (HP:0002570)2.93579775
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.88874238
79Anorexia (HP:0002039)2.88816227
80Pulmonary infiltrates (HP:0002113)2.87663233
81Pulmonary embolism (HP:0002204)2.86525781
82T lymphocytopenia (HP:0005403)2.84096754
83Hepatocellular carcinoma (HP:0001402)2.83176042
84Leukocytosis (HP:0001974)2.81520836
85Gout (HP:0001997)2.78916548
86Skin nodule (HP:0200036)2.78512873
87Abnormality of fatty-acid metabolism (HP:0004359)2.78003660
88Spastic diplegia (HP:0001264)2.76032281
89Abnormality of T cell number (HP:0011839)2.75106015
90Abnormal gallbladder physiology (HP:0012438)2.74836434
91Cholecystitis (HP:0001082)2.74836434
92Epistaxis (HP:0000421)2.70708685
93Metabolic acidosis (HP:0001942)2.68196829
94Spontaneous abortion (HP:0005268)2.68190500
95Abnormality of purine metabolism (HP:0004352)2.65166872
96Status epilepticus (HP:0002133)2.60276399
97Inflammation of the large intestine (HP:0002037)2.57093219
98Lethargy (HP:0001254)2.56558019
99Malnutrition (HP:0004395)2.55531084
100Hypoglycemic seizures (HP:0002173)2.53753653
101Hyperinsulinemic hypoglycemia (HP:0000825)2.53544107
102Osteomyelitis (HP:0002754)2.52323429
103Irritability (HP:0000737)2.52260913
104Microcytic anemia (HP:0001935)2.51816056
105Vascular calcification (HP:0004934)2.48959247
106Abnormality of the lower motor neuron (HP:0002366)2.48600755
107Gangrene (HP:0100758)2.47950662
108Gastrointestinal inflammation (HP:0004386)2.47102254
109Neonatal onset (HP:0003623)2.45658211
110Recurrent viral infections (HP:0004429)2.42539048
111Myocardial infarction (HP:0001658)2.42344831
112Abnormal gallbladder morphology (HP:0012437)2.40670277
113Abnormality of T cells (HP:0002843)2.37902582
114Abnormality of the peritoneum (HP:0002585)2.36899292
115Cholelithiasis (HP:0001081)2.36202948
116Slow saccadic eye movements (HP:0000514)2.35521304
117Sepsis (HP:0100806)2.35234368
118Increased IgM level (HP:0003496)2.34956415
119Abnormality of the pleura (HP:0002103)2.29549884
120Abnormality of the endocardium (HP:0004306)2.28910436
121Dicarboxylic aciduria (HP:0003215)2.27893882
122Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27893882
123Granulocytopenia (HP:0001913)2.22752336
124Cerebral edema (HP:0002181)2.21714923
125Acanthocytosis (HP:0001927)2.21180113
126Vertigo (HP:0002321)2.19470595
127Petechiae (HP:0000967)2.18863329
128Late onset (HP:0003584)2.16617230
129Panhypogammaglobulinemia (HP:0003139)2.16044360
130Lymphopenia (HP:0001888)2.13882289
131Enlarged kidneys (HP:0000105)2.13456862
132Papilledema (HP:0001085)2.13426540
133Pustule (HP:0200039)2.11082189
134Glomerulopathy (HP:0100820)2.10838263
135Acne (HP:0001061)2.10791623
136Cardiovascular calcification (HP:0011915)2.10284326
137Difficulty running (HP:0009046)2.09349920
138Brushfield spots (HP:0001088)2.07026191
139Sensorimotor neuropathy (HP:0007141)2.06845142
140Abnormal platelet volume (HP:0011876)2.05383162
141Pancreatitis (HP:0001733)2.03074870
142Keratitis (HP:0000491)2.01543556
143Mitral stenosis (HP:0001718)2.01406391
144Abnormality of cells of the lymphoid lineage (HP:0012140)2.00508251
145Systemic lupus erythematosus (HP:0002725)2.00277790
146Recurrent pneumonia (HP:0006532)1.98786200
147Abnormality of the gallbladder (HP:0005264)1.98365988
148Rickets (HP:0002748)1.97445871
149Abnormality of T cell physiology (HP:0011840)1.96521800
150Hypergammaglobulinemia (HP:0010702)1.95829130
151Colitis (HP:0002583)1.95796661
152Subacute progressive viral hepatitis (HP:0006572)1.95431867
153Glomerulonephritis (HP:0000099)1.94773946
154Premature loss of primary teeth (HP:0006323)1.92837498
155Skin ulcer (HP:0200042)1.92690977
156Purpura (HP:0000979)1.92583103
157Alkalosis (HP:0001948)1.92571921
158Upper motor neuron abnormality (HP:0002127)1.91846493
159Metaphyseal cupping (HP:0003021)1.91200439
160Vomiting (HP:0002013)1.90791274
161Viral hepatitis (HP:0006562)1.88661561
162Hemorrhage of the eye (HP:0011885)1.88334713
163Eosinophilia (HP:0001880)1.88220206
164Esophageal varix (HP:0002040)1.87633427
165Postural instability (HP:0002172)1.87501384
166Hyperventilation (HP:0002883)1.86544311
167Reticulocytosis (HP:0001923)1.86168257
168Thrombophlebitis (HP:0004418)1.86085059
169Chronic otitis media (HP:0000389)1.85035479
170Abnormality of vitamin metabolism (HP:0100508)1.83586636
171Abnormality of the pericardium (HP:0001697)1.83345747
172Confusion (HP:0001289)1.82470357
173Increased purine levels (HP:0004368)1.81678038
174Hyperuricemia (HP:0002149)1.81678038
175Hyperglycemia (HP:0003074)1.81521763
176Poikilocytosis (HP:0004447)1.80744342
177Opisthotonus (HP:0002179)1.80523227
178Polycythemia (HP:0001901)1.80153346
179Menorrhagia (HP:0000132)1.78364201
180Increased serum ferritin (HP:0003281)1.78308375
181Global brain atrophy (HP:0002283)1.77593171
182Abnormality of the heme biosynthetic pathway (HP:0010472)1.76909124
183Segmental peripheral demyelination/remyelination (HP:0003481)1.76423204
184Polyneuropathy (HP:0001271)1.75645178
185Recurrent gram-negative bacterial infections (HP:0005420)1.74790311
186Hypophosphatemic rickets (HP:0004912)1.74149054
187Hypermelanotic macule (HP:0001034)1.73929514
188Abnormality of iron homeostasis (HP:0011031)1.73733388
189Tetraplegia (HP:0002445)1.73493965
190Skin rash (HP:0000988)1.73323035
191Nasal polyposis (HP:0100582)1.72971002
192Acute hepatic failure (HP:0006554)1.72643460
193Pseudobulbar signs (HP:0002200)1.72515021
194Amyloidosis (HP:0011034)1.72273409
195IgM deficiency (HP:0002850)1.71480469
196Death in childhood (HP:0003819)1.71275965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.67163172
2RIPK45.39591371
3IRAK43.25491379
4SIK13.18323919
5MAP4K13.10474245
6BLK3.08887424
7MAP2K33.06266276
8MAP2K42.94703847
9PDK32.76351170
10PDK42.76351170
11FGFR42.75835561
12EPHA42.73309615
13TYK22.72327605
14ICK2.69367566
15ERN12.50397693
16FES2.49145434
17DAPK22.42275065
18ERBB42.37586049
19TNK22.35920191
20INSRR2.34187222
21TAOK32.26448296
22PRKD32.21354283
23EPHB12.10431493
24PRPF4B2.08766332
25PINK12.08391525
26AKT32.01150734
27MAPK151.97436033
28ZAP701.90037070
29MAP3K41.86909360
30FGR1.83584017
31HCK1.69594924
32PKN21.68721135
33JAK31.66503274
34FLT31.66453360
35MAP3K31.65422418
36BTK1.64602556
37MAP3K91.63906869
38SYK1.57260081
39STK381.57108827
40TXK1.49703736
41PDK21.47849736
42NEK11.46397616
43MAP3K11.45370564
44IKBKE1.43387995
45NTRK31.39175804
46MAP3K141.37210641
47STK38L1.35232091
48MAPK111.31676733
49CDK191.30959646
50JAK11.27492084
51YES11.27124527
52LYN1.25953486
53DAPK11.25268147
54MARK21.25014693
55GRK61.24248993
56LATS11.22157612
57LATS21.21569680
58MAP2K61.19261801
59IRAK21.15634750
60SIK31.15347389
61FRK1.09255581
62IRAK11.06618688
63SIK21.06506757
64TBK11.06498906
65TYRO31.05405553
66PRKCZ1.03626923
67PRKCG1.02519196
68MST1R1.01696194
69LCK0.99604066
70MATK0.95370332
71DYRK1B0.93331174
72MAP3K60.91761209
73PIK3CG0.91391339
74MARK30.91363902
75CSF1R0.91146487
76BMPR20.90675096
77PTK60.90017297
78CAMKK10.88759403
79PRKAA10.87340413
80ABL20.85869196
81TESK10.85742624
82MAP3K100.84549835
83FGFR20.84438064
84ITK0.83798077
85TAOK20.83461093
86KIT0.83031391
87PRKD20.82546208
88SGK30.81130574
89MAP3K20.79481880
90MAP3K110.75836641
91JAK20.73321422
92FYN0.72249287
93LRRK20.71902715
94PDK10.71886529
95TEC0.71771386
96PDPK10.71661502
97PRKACG0.71537944
98RAF10.70672359
99CDK60.70420336
100KSR20.70350224
101PNCK0.70219727
102MAP3K70.69846604
103KSR10.68689129
104SGK20.68470161
105GRK50.67065516
106EPHA20.66934197
107CDK120.66419364
108NTRK10.66408878
109FGFR30.64774491
110PRKAA20.64755230
111PAK60.63603826
112WNK10.63087099
113STK100.61712390
114CAMK2G0.60020420
115GRK10.59443412
116GSK3A0.59165181
117MTOR0.57852978
118TRIB30.57725383
119ERBB20.57512579
120NTRK20.57506055
121TESK20.54048523
122PTK20.53229634
123IKBKB0.52981380
124TTK0.52048246
125MINK10.51321384
126MAP2K70.49183499
127SMG10.49132399
128PRKCQ0.48018469
129SGK2230.47644341
130SGK4940.47644341
131CSNK1E0.47472755
132MAPK40.46295603
133RIPK10.45794633
134MAPK70.45305041
135BMX0.45257216
136RPS6KA30.44076729
137MET0.42927036
138CDC42BPA0.42751730
139EPHA30.42727536
140STK110.41870623
141RPS6KB10.40738690
142PRKCH0.40735660
143PTK2B0.40625606
144CAMK40.39173128
145CSK0.38604273
146PRKG20.37871235
147RET0.35655919
148PIM10.35068105
149CDK40.35050329
150RPS6KC10.34865752
151RPS6KL10.34865752
152HIPK20.34449262
153MAP3K50.33942530
154CAMKK20.33025071
155TGFBR20.32822624
156TAOK10.32209565
157PRKCA0.29684942
158MAP3K130.28571592
159ALK0.24545838
160BRAF0.23522228
161MAPK120.22625144

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.41926024
2Nitrogen metabolism_Homo sapiens_hsa009103.70985189
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.70217707
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34601771
5Arginine biosynthesis_Homo sapiens_hsa002203.25987451
6Osteoclast differentiation_Homo sapiens_hsa043803.10729961
7Leishmaniasis_Homo sapiens_hsa051403.03339911
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63730230
9Tryptophan metabolism_Homo sapiens_hsa003802.63089930
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53867020
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.49821176
12Complement and coagulation cascades_Homo sapiens_hsa046102.44586080
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.38124294
14B cell receptor signaling pathway_Homo sapiens_hsa046622.33257016
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.31430352
16Fatty acid degradation_Homo sapiens_hsa000712.28570878
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23962605
18Tuberculosis_Homo sapiens_hsa051522.23240015
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21670936
20Butanoate metabolism_Homo sapiens_hsa006502.12182840
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.10141381
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09820049
23Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09550251
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94291524
25Chemical carcinogenesis_Homo sapiens_hsa052041.93628861
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91602972
27Peroxisome_Homo sapiens_hsa041461.90061274
28Propanoate metabolism_Homo sapiens_hsa006401.89014108
29Graft-versus-host disease_Homo sapiens_hsa053321.85741400
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.84491870
31Chemokine signaling pathway_Homo sapiens_hsa040621.81993118
32Malaria_Homo sapiens_hsa051441.80765446
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79641257
34Allograft rejection_Homo sapiens_hsa053301.78631055
35Selenocompound metabolism_Homo sapiens_hsa004501.77863488
36PPAR signaling pathway_Homo sapiens_hsa033201.76478339
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.76317515
38Histidine metabolism_Homo sapiens_hsa003401.74721557
39Measles_Homo sapiens_hsa051621.73080151
40Autoimmune thyroid disease_Homo sapiens_hsa053201.69032860
41Acute myeloid leukemia_Homo sapiens_hsa052211.67618108
42Fatty acid metabolism_Homo sapiens_hsa012121.66185874
43Bile secretion_Homo sapiens_hsa049761.63832934
44Primary immunodeficiency_Homo sapiens_hsa053401.61987668
45Retinol metabolism_Homo sapiens_hsa008301.61710733
46beta-Alanine metabolism_Homo sapiens_hsa004101.60796647
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60123739
48Phenylalanine metabolism_Homo sapiens_hsa003601.59536968
49Caffeine metabolism_Homo sapiens_hsa002321.58812692
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57113972
51Legionellosis_Homo sapiens_hsa051341.55257669
52T cell receptor signaling pathway_Homo sapiens_hsa046601.54875356
53Pyruvate metabolism_Homo sapiens_hsa006201.53471045
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.52723652
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49329991
56Influenza A_Homo sapiens_hsa051641.46334687
57Biosynthesis of amino acids_Homo sapiens_hsa012301.44566196
58Toxoplasmosis_Homo sapiens_hsa051451.38944242
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.38768724
60Non-small cell lung cancer_Homo sapiens_hsa052231.37922434
61Staphylococcus aureus infection_Homo sapiens_hsa051501.37787213
62Type I diabetes mellitus_Homo sapiens_hsa049401.37578736
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37537377
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37091368
65Tyrosine metabolism_Homo sapiens_hsa003501.36487820
66Phagosome_Homo sapiens_hsa041451.36379227
67Hematopoietic cell lineage_Homo sapiens_hsa046401.35842172
68Jak-STAT signaling pathway_Homo sapiens_hsa046301.32849047
69Sulfur metabolism_Homo sapiens_hsa009201.27321914
70Leukocyte transendothelial migration_Homo sapiens_hsa046701.26966308
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26866656
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26368655
73Antigen processing and presentation_Homo sapiens_hsa046121.22636621
74Starch and sucrose metabolism_Homo sapiens_hsa005001.21917028
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21224838
76Carbon metabolism_Homo sapiens_hsa012001.20087162
77Cyanoamino acid metabolism_Homo sapiens_hsa004601.18933793
78Platelet activation_Homo sapiens_hsa046111.16940218
79Maturity onset diabetes of the young_Homo sapiens_hsa049501.16649176
80ABC transporters_Homo sapiens_hsa020101.16234559
81TNF signaling pathway_Homo sapiens_hsa046681.16082769
82Viral myocarditis_Homo sapiens_hsa054161.15667395
83Herpes simplex infection_Homo sapiens_hsa051681.15648217
84Fat digestion and absorption_Homo sapiens_hsa049751.15494966
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13410419
86Hepatitis B_Homo sapiens_hsa051611.13390055
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12021618
88Vitamin B6 metabolism_Homo sapiens_hsa007501.08938104
89VEGF signaling pathway_Homo sapiens_hsa043701.08442084
90Hepatitis C_Homo sapiens_hsa051601.07477141
91Folate biosynthesis_Homo sapiens_hsa007901.05038361
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01657717
93Arginine and proline metabolism_Homo sapiens_hsa003300.98270302
94Pancreatic cancer_Homo sapiens_hsa052120.97576957
95Pertussis_Homo sapiens_hsa051330.97239131
96One carbon pool by folate_Homo sapiens_hsa006700.95837648
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.94778674
98Salmonella infection_Homo sapiens_hsa051320.94498125
99Fatty acid elongation_Homo sapiens_hsa000620.93471762
100Prolactin signaling pathway_Homo sapiens_hsa049170.92649831
101Renal cell carcinoma_Homo sapiens_hsa052110.90733838
102Chronic myeloid leukemia_Homo sapiens_hsa052200.90191281
103Endocytosis_Homo sapiens_hsa041440.87710807
104Shigellosis_Homo sapiens_hsa051310.86535685
105Steroid biosynthesis_Homo sapiens_hsa001000.86434244
106Dorso-ventral axis formation_Homo sapiens_hsa043200.85394999
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83812157
108Apoptosis_Homo sapiens_hsa042100.81870755
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.81626599
110Lysine degradation_Homo sapiens_hsa003100.80764436
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.80511108
112GnRH signaling pathway_Homo sapiens_hsa049120.80233812
113Long-term potentiation_Homo sapiens_hsa047200.79245196
114Glycerolipid metabolism_Homo sapiens_hsa005610.78086971
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76690464
116FoxO signaling pathway_Homo sapiens_hsa040680.75642453
117Endometrial cancer_Homo sapiens_hsa052130.75557084
118Sulfur relay system_Homo sapiens_hsa041220.75200445
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74009631
120Fatty acid biosynthesis_Homo sapiens_hsa000610.73841983
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.73240326
122Vitamin digestion and absorption_Homo sapiens_hsa049770.71438964
123Choline metabolism in cancer_Homo sapiens_hsa052310.71141647
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70457634
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70267927
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69377493
127Inositol phosphate metabolism_Homo sapiens_hsa005620.68542631
128Notch signaling pathway_Homo sapiens_hsa043300.67778036
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66734860
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65699534
131Amoebiasis_Homo sapiens_hsa051460.63606625
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62913482
133Rheumatoid arthritis_Homo sapiens_hsa053230.61114854
134Regulation of autophagy_Homo sapiens_hsa041400.59738384
135MAPK signaling pathway_Homo sapiens_hsa040100.59585618
136ErbB signaling pathway_Homo sapiens_hsa040120.59043490
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58674670
138HIF-1 signaling pathway_Homo sapiens_hsa040660.58361909
139Pentose phosphate pathway_Homo sapiens_hsa000300.57950280
140Glutathione metabolism_Homo sapiens_hsa004800.57038452
141Fructose and mannose metabolism_Homo sapiens_hsa000510.56896904
142mTOR signaling pathway_Homo sapiens_hsa041500.56367379
143Rap1 signaling pathway_Homo sapiens_hsa040150.56017162
144Estrogen signaling pathway_Homo sapiens_hsa049150.54107766
145Other glycan degradation_Homo sapiens_hsa005110.51469229
146Glioma_Homo sapiens_hsa052140.51447254
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50432195
148Viral carcinogenesis_Homo sapiens_hsa052030.49945928
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49658321
150Asthma_Homo sapiens_hsa053100.49535918
151Colorectal cancer_Homo sapiens_hsa052100.49336260
152Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49041024
153Epstein-Barr virus infection_Homo sapiens_hsa051690.48172893
154Cholinergic synapse_Homo sapiens_hsa047250.46963825
155Metabolic pathways_Homo sapiens_hsa011000.43690061
156Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42198613
157Gastric acid secretion_Homo sapiens_hsa049710.40248202
158Glucagon signaling pathway_Homo sapiens_hsa049220.39638678
159Linoleic acid metabolism_Homo sapiens_hsa005910.33998851
160Prion diseases_Homo sapiens_hsa050200.32852854
161alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32648488
162Galactose metabolism_Homo sapiens_hsa000520.29064866
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.28376620
164Insulin resistance_Homo sapiens_hsa049310.20290408
165Adipocytokine signaling pathway_Homo sapiens_hsa049200.14458578
166AMPK signaling pathway_Homo sapiens_hsa041520.09696905
167Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.01600188
168Synaptic vesicle cycle_Homo sapiens_hsa04721-0.1876856
169Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1867632
170African trypanosomiasis_Homo sapiens_hsa05143-0.1848379
171Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1754769
172Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1645522
173Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1448860
174Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.1385290
175Nicotine addiction_Homo sapiens_hsa05033-0.1218252
176Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1019018
177Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0951918
178Amphetamine addiction_Homo sapiens_hsa05031-0.0888232
179Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0875914
180Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0837744
181Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0826909
182Insulin secretion_Homo sapiens_hsa04911-0.0614809
183Insulin signaling pathway_Homo sapiens_hsa04910-0.0477752
184Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0456471
185Type II diabetes mellitus_Homo sapiens_hsa04930-0.0327330
186GABAergic synapse_Homo sapiens_hsa04727-0.0173036
187Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0161536
188Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0136880

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »