GLTSCR1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.79817752
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34495018
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.17037355
4locomotory exploration behavior (GO:0035641)5.13234391
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.91072078
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.84784574
7regulation of B cell receptor signaling pathway (GO:0050855)4.77827240
8synaptic vesicle maturation (GO:0016188)4.67872143
9regulation of gamma-delta T cell activation (GO:0046643)4.61987521
10regulation of gamma-delta T cell differentiation (GO:0045586)4.56306857
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.40676024
12modulation by symbiont of host immune response (GO:0052553)4.34258506
13positive regulation by symbiont of host defense response (GO:0052509)4.34258506
14modulation by symbiont of host defense response (GO:0052031)4.34258506
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.34258506
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.34258506
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.34258506
18vocalization behavior (GO:0071625)4.25364988
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.23694933
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.13040222
21antigen processing and presentation of endogenous antigen (GO:0019883)4.11912722
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.11239168
23cellular potassium ion homeostasis (GO:0030007)4.10476214
24glutamate secretion (GO:0014047)4.09870304
25regulation of synaptic vesicle exocytosis (GO:2000300)4.06450048
26response to interleukin-15 (GO:0070672)4.02029853
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.00835957
28synaptic vesicle exocytosis (GO:0016079)3.98749945
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.97683197
30negative T cell selection (GO:0043383)3.97652926
31negative thymic T cell selection (GO:0045060)3.96455477
32pre-miRNA processing (GO:0031054)3.96328813
33sodium ion export (GO:0071436)3.96177470
34cerebellar Purkinje cell differentiation (GO:0021702)3.90877601
35B cell receptor signaling pathway (GO:0050853)3.88846888
36regulation of glutamate receptor signaling pathway (GO:1900449)3.81173157
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.76551699
38cellular extravasation (GO:0045123)3.74145270
39negative regulation of T cell mediated immunity (GO:0002710)3.71077188
40positive T cell selection (GO:0043368)3.70938180
41positive regulation of granulocyte differentiation (GO:0030854)3.69347395
42macrophage activation involved in immune response (GO:0002281)3.65683671
43glutamate receptor signaling pathway (GO:0007215)3.64600209
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.63170277
45regulation of ARF protein signal transduction (GO:0032012)3.63106659
46positive regulation of synapse maturation (GO:0090129)3.61205772
47synaptic transmission, glutamatergic (GO:0035249)3.59678489
48regulation of clathrin-mediated endocytosis (GO:2000369)3.59432682
49neurotransmitter secretion (GO:0007269)3.58631276
50protein localization to synapse (GO:0035418)3.56330107
51long-term memory (GO:0007616)3.54861979
52positive thymic T cell selection (GO:0045059)3.54523197
53cellular response to interleukin-15 (GO:0071350)3.53034507
54positive regulation of dendritic spine morphogenesis (GO:0061003)3.52583060
55regulation of synaptic vesicle transport (GO:1902803)3.48842323
56activated T cell proliferation (GO:0050798)3.46289614
57negative regulation of erythrocyte differentiation (GO:0045647)3.45193993
58detection of other organism (GO:0098543)3.44956115
59regulation of neuronal synaptic plasticity (GO:0048168)3.43376690
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.42462472
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42146743
62detection of molecule of bacterial origin (GO:0032490)3.42030235
63exploration behavior (GO:0035640)3.40856063
64T cell selection (GO:0045058)3.40794232
65leukocyte aggregation (GO:0070486)3.38960507
66production of molecular mediator involved in inflammatory response (GO:0002532)3.31149392
67neutrophil activation involved in immune response (GO:0002283)3.29822113
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.29237289
69positive regulation of B cell differentiation (GO:0045579)3.26373366
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25803583
71thymic T cell selection (GO:0045061)3.25731783
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24844007
73neurotransmitter-gated ion channel clustering (GO:0072578)3.22914218
74layer formation in cerebral cortex (GO:0021819)3.22277374
75synaptic vesicle endocytosis (GO:0048488)3.21345002
76negative regulation of leukocyte mediated immunity (GO:0002704)3.20840145
77detection of bacterium (GO:0016045)3.19744094
78activation of protein kinase A activity (GO:0034199)3.19307799
79gamma-aminobutyric acid transport (GO:0015812)3.18680573
80neuron-neuron synaptic transmission (GO:0007270)3.18377456
81response to host immune response (GO:0052572)3.17448253
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17448253
83phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.16630843
84regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16437146
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.16035657
86microglial cell activation (GO:0001774)3.14007412
87proline transport (GO:0015824)3.13992579
88neuromuscular process controlling balance (GO:0050885)3.12310472
89regulation of interferon-beta biosynthetic process (GO:0045357)3.12187791
90detection of external biotic stimulus (GO:0098581)3.12028329
91histone H3-K36 demethylation (GO:0070544)3.11487010
92regulation of B cell differentiation (GO:0045577)3.09900439
93regulation of dendritic spine morphogenesis (GO:0061001)3.05911705
94negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04416458
95negative regulation of T-helper cell differentiation (GO:0045623)3.04416458
96regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04334936
97regulation of postsynaptic membrane potential (GO:0060078)3.04169883
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03291948
99negative regulation of histone methylation (GO:0031061)3.03095837
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98862989
101response to host (GO:0075136)2.98862989
102response to host defenses (GO:0052200)2.98862989
103positive regulation of Rap GTPase activity (GO:0032854)2.97465969
104germinal center formation (GO:0002467)2.96234113
105T cell migration (GO:0072678)2.96029788
106histone H3-K4 methylation (GO:0051568)2.95789900
107prepulse inhibition (GO:0060134)2.95507712
108positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95315777
109positive regulation of membrane potential (GO:0045838)2.94044024
110neuromuscular process controlling posture (GO:0050884)2.93751933
111tolerance induction (GO:0002507)2.93234847
112cytoskeletal anchoring at plasma membrane (GO:0007016)2.91952985
113cerebellar granule cell differentiation (GO:0021707)2.91094803
114regulation of synapse structural plasticity (GO:0051823)2.89806249
115gamma-aminobutyric acid signaling pathway (GO:0007214)2.88226325
116regulation of synaptic plasticity (GO:0048167)2.88096106
117negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86384379
118negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.86324058
119response to peptidoglycan (GO:0032494)2.85104423
120neutrophil activation (GO:0042119)2.84195543
121neurotransmitter transport (GO:0006836)2.82274234
122regulation of T cell tolerance induction (GO:0002664)2.81326653
123nerve growth factor signaling pathway (GO:0038180)2.80405328
124cell communication by electrical coupling (GO:0010644)2.80396378
125regulation of regulatory T cell differentiation (GO:0045589)2.79566915
126positive regulation of cellular amide metabolic process (GO:0034250)2.78937607
127macrophage activation (GO:0042116)2.78716092
128regulation of tolerance induction (GO:0002643)2.78068370
129membrane depolarization during action potential (GO:0086010)2.77701565
130long-term synaptic potentiation (GO:0060291)2.76992908
131negative regulation of interleukin-12 production (GO:0032695)2.76706393
132regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74706839
133histone H3-K4 trimethylation (GO:0080182)2.74464526
134neuronal action potential propagation (GO:0019227)2.74162177
135positive regulation of tolerance induction (GO:0002645)2.73701925
136antigen processing and presentation via MHC class Ib (GO:0002475)2.73660385
137regulation of ARF GTPase activity (GO:0032312)2.73629947
138response to histamine (GO:0034776)2.72977015
139regulation of synaptic transmission, glutamatergic (GO:0051966)2.72917849
140histone H3-K9 demethylation (GO:0033169)2.71687835
141interferon-gamma production (GO:0032609)2.70462403
142chemosensory behavior (GO:0007635)2.70397781
143neuron cell-cell adhesion (GO:0007158)2.69967865
144dendritic spine morphogenesis (GO:0060997)2.69027305
145antigen receptor-mediated signaling pathway (GO:0050851)2.68525942
146regulation of alpha-beta T cell proliferation (GO:0046640)2.67368014
147potassium ion import (GO:0010107)2.67099274
148cell differentiation in hindbrain (GO:0021533)2.66976790
149myeloid cell activation involved in immune response (GO:0002275)2.66286579
150regulation of neurotransmitter secretion (GO:0046928)2.66100547
151protein targeting to Golgi (GO:0000042)2.66086973
152peptidyl-threonine phosphorylation (GO:0018107)2.65694019
153positive regulation of dendritic spine development (GO:0060999)2.64555542
154negative regulation of adaptive immune response (GO:0002820)2.64148217
155megakaryocyte development (GO:0035855)2.63182162
156B cell homeostasis (GO:0001782)2.63147716
157negative regulation of cell killing (GO:0031342)2.62008129
158negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.62008129
159potassium ion homeostasis (GO:0055075)2.61855507
160membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61845471
161histone H4-K12 acetylation (GO:0043983)2.61688109
162long term synaptic depression (GO:0060292)2.61642179
163negative regulation of type 2 immune response (GO:0002829)2.61199391
164innervation (GO:0060384)2.60975009
165signal complex assembly (GO:0007172)2.60893746
166membrane depolarization (GO:0051899)2.60395313
167regulation of neurotransmitter levels (GO:0001505)2.59971841
168detection of biotic stimulus (GO:0009595)2.59144835
169behavioral defense response (GO:0002209)2.58700550
170behavioral fear response (GO:0001662)2.58700550
171regulation of granulocyte differentiation (GO:0030852)2.57804348
172cell migration in hindbrain (GO:0021535)2.57788806
173regulation of Rap GTPase activity (GO:0032317)2.56462858
174histone H4-K16 acetylation (GO:0043984)2.56331269
175vesicle transport along microtubule (GO:0047496)2.56044924
176response to muramyl dipeptide (GO:0032495)2.55838667
177negative regulation of glycoprotein biosynthetic process (GO:0010561)2.55255836
178cellular response to type I interferon (GO:0071357)2.54910658
179type I interferon signaling pathway (GO:0060337)2.54910658
180response to type I interferon (GO:0034340)2.54877682
181regulation of natural killer cell mediated immunity (GO:0002715)2.54742894
182regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.54742894
183transmission of nerve impulse (GO:0019226)2.54736510
184membrane hyperpolarization (GO:0060081)2.54159963
185regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54154355
186establishment of nucleus localization (GO:0040023)2.52765720
187negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.52688005
188neutrophil mediated immunity (GO:0002446)2.52615868
189stress granule assembly (GO:0034063)2.51208096
190establishment of protein localization to Golgi (GO:0072600)2.50462136
191granulocyte activation (GO:0036230)2.50285672
192cellular response to ethanol (GO:0071361)2.48627460
193regulation of platelet aggregation (GO:0090330)2.48248318
194T cell homeostasis (GO:0043029)2.45694097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.25557742
2EZH2_22144423_ChIP-Seq_EOC_Human4.21132915
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.07594899
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.10614504
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.06933388
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.05664694
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91587682
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81664548
9DROSHA_22980978_ChIP-Seq_HELA_Human2.76685498
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71218469
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.50440395
12REST_21632747_ChIP-Seq_MESCs_Mouse2.45971670
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.44532426
14SCL_19346495_ChIP-Seq_HPC-7_Human2.40865808
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36014230
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35883717
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35807018
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33560926
19MYB_26560356_Chip-Seq_TH2_Human2.21741165
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20245079
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.19805974
22GATA1_22025678_ChIP-Seq_K562_Human2.19550289
23GBX2_23144817_ChIP-Seq_PC3_Human2.15542393
24MYC_22102868_ChIP-Seq_BL_Human2.05965321
25ZFP281_27345836_Chip-Seq_ESCs_Mouse2.05875439
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05202117
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.04300150
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01937275
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.96177037
30MYB_26560356_Chip-Seq_TH1_Human1.95123364
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.94603950
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93198244
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.92182166
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.91340708
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.90739551
36MAF_26560356_Chip-Seq_TH1_Human1.87770741
37KDM2B_26808549_Chip-Seq_DND41_Human1.87407872
38KDM2B_26808549_Chip-Seq_K562_Human1.82285410
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.81534573
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80972643
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76843722
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75406768
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.75243393
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74444677
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74237769
46VDR_24763502_ChIP-Seq_THP-1_Human1.73734136
47VDR_24787735_ChIP-Seq_THP-1_Human1.70817414
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69625640
49GATA3_27048872_Chip-Seq_THYMUS_Human1.67911562
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.65424889
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65211804
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64223771
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.58939943
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.58919609
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58805226
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57898574
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57527736
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.55936770
59TCF7_22412390_ChIP-Seq_EML_Mouse1.55258180
60UTX_26944678_Chip-Seq_JUKART_Human1.54769446
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53742208
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.52821732
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52660139
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52447713
65GATA1_19941826_ChIP-Seq_K562_Human1.50236382
66SPI1_23547873_ChIP-Seq_NB4_Human1.48968937
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47371390
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.46977872
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.46028951
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43236467
71AR_21572438_ChIP-Seq_LNCaP_Human1.41405540
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41009361
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39947780
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39511564
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38020717
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37838469
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36773701
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36352586
79AR_19668381_ChIP-Seq_PC3_Human1.36247864
80NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.35481550
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34303936
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33807881
83GATA2_19941826_ChIP-Seq_K562_Human1.30796817
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30465072
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.29923394
86VDR_21846776_ChIP-Seq_THP-1_Human1.28069192
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27341032
88JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27209918
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26937682
90TP53_16413492_ChIP-PET_HCT116_Human1.26833458
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25889906
92RUNX_20019798_ChIP-Seq_JUKART_Human1.25690404
93SMAD4_21799915_ChIP-Seq_A2780_Human1.25483142
94PU_27001747_Chip-Seq_BMDM_Mouse1.23169767
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.23075424
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22993464
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22849438
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21912158
99TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21315296
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.21245633
101STAT3_23295773_ChIP-Seq_U87_Human1.20999259
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.20880887
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20431235
104MAF_26560356_Chip-Seq_TH2_Human1.20342555
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19217227
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19108891
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18564401
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17479750
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.13877060
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13376356
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13317802
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12486720
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12061631
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11728230
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11341339
116GATA3_26560356_Chip-Seq_TH2_Human1.11311893
117EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10892818
118RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10892818
119ESR1_20079471_ChIP-ChIP_T-47D_Human1.10474878
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07807986
121FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06606833
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06269630
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04566233
124TCF4_23295773_ChIP-Seq_U87_Human1.03671020
125PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03420120
126TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03402278
127POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03307403
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02881326
129GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02294782
130CREB1_26743006_Chip-Seq_LNCaP_Human1.02178550
131KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01614482
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00137026
133TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00004276
134PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99887356
135SPI1_23127762_ChIP-Seq_K562_Human0.98336380
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97967412
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.97873759
138GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97098490
139AHR_22903824_ChIP-Seq_MCF-7_Human0.96854914
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96324588
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96324588
142ERG_21242973_ChIP-ChIP_JURKAT_Human0.96210332
143ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95910347
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.95855734
145DPY_21335234_ChIP-Seq_ESCs_Mouse0.94841691
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.94176551
147KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93953309
148KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93953309
149KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93953309
150FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93943611
151JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92698600
152E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92228607
153EZH2_27294783_Chip-Seq_ESCs_Mouse0.91330287
154SMRT_27268052_Chip-Seq_Bcells_Human0.87179160
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85912938
156THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84789087
157CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84058666
158FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83818808
159NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83107354
160FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82414518
161KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81819148
162NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81217013
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79193521
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78817010
165GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76357679
166FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.74949665
167GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74077583
168CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73083296
169STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71543264
170SOX2_27498859_Chip-Seq_STOMACH_Mouse0.70927149
171CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70669024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.23588992
2MP0003635_abnormal_synaptic_transmissio3.85039891
3MP0003724_increased_susceptibility_to3.61714177
4MP0003787_abnormal_imprinting3.59177222
5MP0003763_abnormal_thymus_physiology3.41996694
6MP0001835_abnormal_antigen_presentation3.26121308
7MP0003436_decreased_susceptibility_to3.04998287
8MP0003880_abnormal_central_pattern2.98734981
9MP0002063_abnormal_learning/memory/cond2.94467873
10MP0009745_abnormal_behavioral_response2.93623784
11MP0004270_analgesia2.90734330
12MP0009046_muscle_twitch2.88152749
13MP0002064_seizures2.75663388
14MP0001800_abnormal_humoral_immune2.69122591
15MP0005671_abnormal_response_to2.66330871
16MP0002166_altered_tumor_susceptibility2.66114203
17MP0002822_catalepsy2.58277220
18MP0002009_preneoplasia2.53625694
19MP0000685_abnormal_immune_system2.50255732
20MP0005000_abnormal_immune_tolerance2.41227592
21MP0002572_abnormal_emotion/affect_behav2.36704666
22MP0005387_immune_system_phenotype2.31555016
23MP0001790_abnormal_immune_system2.31555016
24MP0008961_abnormal_basal_metabolism2.26818524
25MP0002723_abnormal_immune_serum2.22557714
26MP0002420_abnormal_adaptive_immunity2.21952148
27MP0001819_abnormal_immune_cell2.18151421
28MP0002419_abnormal_innate_immunity2.17419652
29MP0005423_abnormal_somatic_nervous2.11865408
30MP0008569_lethality_at_weaning2.11521421
31MP0002909_abnormal_adrenal_gland2.10675826
32MP0001486_abnormal_startle_reflex2.10560612
33MP0005464_abnormal_platelet_physiology2.09663171
34MP0002272_abnormal_nervous_system2.07911092
35MP0005025_abnormal_response_to2.07506814
36MP0002452_abnormal_antigen_presenting2.07384743
37MP0009780_abnormal_chondrocyte_physiolo2.04163881
38MP0002398_abnormal_bone_marrow2.03036740
39MP0001501_abnormal_sleep_pattern1.94526912
40MP0000716_abnormal_immune_system1.80750738
41MP0005646_abnormal_pituitary_gland1.76825715
42MP0004885_abnormal_endolymph1.76325497
43MP0002405_respiratory_system_inflammati1.76255872
44MP0005451_abnormal_body_composition1.74776628
45MP0003183_abnormal_peptide_metabolism1.73982494
46MP0001968_abnormal_touch/_nociception1.69506311
47MP0009785_altered_susceptibility_to1.69183230
48MP0002006_tumorigenesis1.68944524
49MP0003303_peritoneal_inflammation1.68003272
50MP0004947_skin_inflammation1.66206080
51MP0010234_abnormal_vibrissa_follicle1.62405566
52MP0002734_abnormal_mechanical_nocicepti1.61543783
53MP0000689_abnormal_spleen_morphology1.60815841
54MP0005551_abnormal_eye_electrophysiolog1.60440023
55MP0008260_abnormal_autophagy1.58999090
56MP0002722_abnormal_immune_system1.58868001
57MP0004381_abnormal_hair_follicle1.57574891
58MP0008057_abnormal_DNA_replication1.57443421
59MP0010155_abnormal_intestine_physiology1.54158352
60MP0002067_abnormal_sensory_capabilities1.53800900
61MP0000465_gastrointestinal_hemorrhage1.51430333
62MP0006082_CNS_inflammation1.50631893
63MP0003656_abnormal_erythrocyte_physiolo1.48053587
64MP0001851_eye_inflammation1.43744758
65MP0001440_abnormal_grooming_behavior1.43288212
66MP0004811_abnormal_neuron_physiology1.42893438
67MP0006072_abnormal_retinal_apoptosis1.41887722
68MP0001533_abnormal_skeleton_physiology1.41604280
69MP0004808_abnormal_hematopoietic_stem1.39920888
70MP0003191_abnormal_cellular_cholesterol1.39656491
71MP0003633_abnormal_nervous_system1.38461496
72MP0005386_behavior/neurological_phenoty1.37698966
73MP0004924_abnormal_behavior1.37698966
74MP0002429_abnormal_blood_cell1.37248553
75MP0001845_abnormal_inflammatory_respons1.37072562
76MP0003045_fibrosis1.35963034
77MP0003123_paternal_imprinting1.35679480
78MP0003283_abnormal_digestive_organ1.35443524
79MP0009333_abnormal_splenocyte_physiolog1.34360244
80MP0008877_abnormal_DNA_methylation1.31293480
81MP0003828_pulmonary_edema1.29187045
82MP0005409_darkened_coat_color1.29030119
83MP0005645_abnormal_hypothalamus_physiol1.28461769
84MP0002735_abnormal_chemical_nociception1.27095201
85MP0003879_abnormal_hair_cell1.25963629
86MP0004883_abnormal_blood_vessel1.25931666
87MP0004510_myositis1.25906947
88MP0002557_abnormal_social/conspecific_i1.24904678
89MP0000955_abnormal_spinal_cord1.24763932
90MP0004858_abnormal_nervous_system1.22336055
91MP0000015_abnormal_ear_pigmentation1.22103299
92MP0005076_abnormal_cell_differentiation1.21420367
93MP0008004_abnormal_stomach_pH1.20748399
94MP0006292_abnormal_olfactory_placode1.20625924
95MP0002184_abnormal_innervation1.19015160
96MP0002148_abnormal_hypersensitivity_rea1.18943755
97MP0000569_abnormal_digit_pigmentation1.18183436
98MP0002882_abnormal_neuron_morphology1.17324778
99MP0008874_decreased_physiological_sensi1.17153578
100MP0001970_abnormal_pain_threshold1.16193810
101MP0002733_abnormal_thermal_nociception1.16018680
102MP0003121_genomic_imprinting1.15047682
103MP0002229_neurodegeneration1.15029066
104MP0008872_abnormal_physiological_respon1.14926131
105MP0002152_abnormal_brain_morphology1.13624933
106MP0003091_abnormal_cell_migration1.12611185
107MP0002066_abnormal_motor_capabilities/c1.12097823
108MP0002653_abnormal_ependyma_morphology1.11607290
109MP0005397_hematopoietic_system_phenotyp1.10933729
110MP0001545_abnormal_hematopoietic_system1.10933729
111MP0009278_abnormal_bone_marrow1.10385035
112MP0002998_abnormal_bone_remodeling1.09651074
113MP0001873_stomach_inflammation1.08157508
114MP0001502_abnormal_circadian_rhythm1.07102928
115MP0004233_abnormal_muscle_weight1.05882689
116MP0000778_abnormal_nervous_system1.05461056
117MP0003631_nervous_system_phenotype1.04655594
118MP0002736_abnormal_nociception_after1.02661841
119MP0003172_abnormal_lysosome_physiology1.00403652
120MP0002396_abnormal_hematopoietic_system0.98433987
121MP0005075_abnormal_melanosome_morpholog0.98214648
122MP0002693_abnormal_pancreas_physiology0.97683100
123MP0010307_abnormal_tumor_latency0.96627618
124MP0003329_amyloid_beta_deposits0.93317941
125MP0008770_decreased_survivor_rate0.92075303
126MP0000858_altered_metastatic_potential0.91976194
127MP0003690_abnormal_glial_cell0.90832870
128MP0004264_abnormal_extraembryonic_tissu0.89543728
129MP0008469_abnormal_protein_level0.87831724
130MP0002089_abnormal_postnatal_growth/wei0.87600341
131MP0004484_altered_response_of0.87005066
132MP0003300_gastrointestinal_ulcer0.82068025
133MP0005253_abnormal_eye_physiology0.81021097
134MP0005394_taste/olfaction_phenotype0.78694934
135MP0005499_abnormal_olfactory_system0.78694934
136MP0000631_abnormal_neuroendocrine_gland0.78644784
137MP0003861_abnormal_nervous_system0.77348791
138MP0009115_abnormal_fat_cell0.76722342
139MP0005164_abnormal_response_to0.75949100
140MP0003075_altered_response_to0.75149044
141MP0003632_abnormal_nervous_system0.74078335
142MP0002090_abnormal_vision0.73749702
143MP0004085_abnormal_heartbeat0.73002504
144MP0004145_abnormal_muscle_electrophysio0.72865412
145MP0004142_abnormal_muscle_tone0.72729432
146MP0002069_abnormal_eating/drinking_beha0.72569747
147MP0010769_abnormal_survival0.72279817
148MP0001849_ear_inflammation0.71307134
149MP0002332_abnormal_exercise_endurance0.70502090
150MP0002084_abnormal_developmental_patter0.70371856
151MP0005166_decreased_susceptibility_to0.69182092
152MP0010768_mortality/aging0.68991951
153MP0004130_abnormal_muscle_cell0.68482621
154MP0000751_myopathy0.67851566
155MP0000249_abnormal_blood_vessel0.66920654
156MP0000920_abnormal_myelination0.65260391
157MP0001984_abnormal_olfaction0.65020709
158MP0002933_joint_inflammation0.64870473
159MP0002132_abnormal_respiratory_system0.64241466
160MP0000703_abnormal_thymus_morphology0.64106329
161MP0010770_preweaning_lethality0.63191301
162MP0002082_postnatal_lethality0.63191301
163MP0001853_heart_inflammation0.63178235
164MP0005670_abnormal_white_adipose0.62966874
165MP0001963_abnormal_hearing_physiology0.62594920
166MP0001765_abnormal_ion_homeostasis0.62523583
167MP0010352_gastrointestinal_tract_polyps0.61204404
168MP0002277_abnormal_respiratory_mucosa0.60912838
169MP0005310_abnormal_salivary_gland0.60871906
170MP0002086_abnormal_extraembryonic_tissu0.59991740
171MP0005174_abnormal_tail_pigmentation0.58326976
172MP0003221_abnormal_cardiomyocyte_apopto0.58321065
173MP0003866_abnormal_defecation0.57901555
174MP0002078_abnormal_glucose_homeostasis0.57316153
175MP0005535_abnormal_body_temperature0.55427142
176MP0003453_abnormal_keratinocyte_physiol0.54932515
177MP0003448_altered_tumor_morphology0.54453031
178MP0002971_abnormal_brown_adipose0.54265033
179MP0003795_abnormal_bone_structure0.53951291
180MP0001915_intracranial_hemorrhage0.52611631

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.94320872
2Focal motor seizures (HP:0011153)4.94226967
3Visual hallucinations (HP:0002367)4.39807403
4Focal seizures (HP:0007359)4.19451692
5Recurrent bacterial skin infections (HP:0005406)4.08423874
6Myositis (HP:0100614)3.95257000
7Recurrent abscess formation (HP:0002722)3.94641873
8Retrobulbar optic neuritis (HP:0100654)3.83932199
9Optic neuritis (HP:0100653)3.83932199
10Orchitis (HP:0100796)3.78016727
11T lymphocytopenia (HP:0005403)3.73628362
12Genetic anticipation (HP:0003743)3.68143699
13Spontaneous hematomas (HP:0007420)3.59265422
14Prolonged bleeding time (HP:0003010)3.59250524
15Dysmetric saccades (HP:0000641)3.53197301
16Gastrointestinal infarctions (HP:0005244)3.51519060
17Abnormality of T cell number (HP:0011839)3.47832831
18Abnormality of the lower motor neuron (HP:0002366)3.44799285
19Febrile seizures (HP:0002373)3.44393614
20Myokymia (HP:0002411)3.44040184
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.37851908
22Abnormality of macrophages (HP:0004311)3.34273032
23Progressive cerebellar ataxia (HP:0002073)3.33565845
24Astrocytoma (HP:0009592)3.31276520
25Abnormality of the astrocytes (HP:0100707)3.31276520
26Impaired smooth pursuit (HP:0007772)3.24527640
27Gingival bleeding (HP:0000225)3.19285514
28Postural instability (HP:0002172)3.18257337
29Epileptic encephalopathy (HP:0200134)3.15486354
30Vasculitis (HP:0002633)3.10977735
31Stomatitis (HP:0010280)3.09744827
32Recurrent fungal infections (HP:0002841)3.08815704
33Ependymoma (HP:0002888)3.07715689
34Meningitis (HP:0001287)3.03778133
35Dysdiadochokinesis (HP:0002075)2.95333009
36Inflammation of the large intestine (HP:0002037)2.95028165
37Dialeptic seizures (HP:0011146)2.90852910
38Chest pain (HP:0100749)2.89664782
39Atonic seizures (HP:0010819)2.89634598
40Urinary bladder sphincter dysfunction (HP:0002839)2.89506051
41Absence seizures (HP:0002121)2.89262742
42Gaze-evoked nystagmus (HP:0000640)2.88082954
43Abnormality of ocular smooth pursuit (HP:0000617)2.86193196
44Gingivitis (HP:0000230)2.86152625
45Action tremor (HP:0002345)2.85630437
46Keratoconjunctivitis sicca (HP:0001097)2.85206809
47Macroorchidism (HP:0000053)2.83638212
48Recurrent skin infections (HP:0001581)2.83297068
49Gastrointestinal inflammation (HP:0004386)2.82346121
50Volvulus (HP:0002580)2.81292110
51Increased IgE level (HP:0003212)2.77133189
52Broad-based gait (HP:0002136)2.74628384
53Recurrent gram-negative bacterial infections (HP:0005420)2.74417179
54Abnormality of the fingertips (HP:0001211)2.74073153
55Arterial thrombosis (HP:0004420)2.72566054
56Epistaxis (HP:0000421)2.68452115
57Elevated erythrocyte sedimentation rate (HP:0003565)2.67651505
58Abnormality of T cells (HP:0002843)2.65938861
59Recurrent cutaneous fungal infections (HP:0011370)2.65647245
60Chronic mucocutaneous candidiasis (HP:0002728)2.65647245
61Hemiplegia (HP:0002301)2.64833898
62Neoplasm of the heart (HP:0100544)2.63984320
63Keratoconjunctivitis (HP:0001096)2.62623748
64Mediastinal lymphadenopathy (HP:0100721)2.62616469
65Colitis (HP:0002583)2.61742279
66Encephalitis (HP:0002383)2.60119290
67Truncal ataxia (HP:0002078)2.58526276
68Neoplasm of the oral cavity (HP:0100649)2.57097568
69Recurrent viral infections (HP:0004429)2.55979353
70Subacute progressive viral hepatitis (HP:0006572)2.52567100
71Cellulitis (HP:0100658)2.50991103
72Impaired social interactions (HP:0000735)2.50689935
73Abnormal social behavior (HP:0012433)2.50689935
74Pulmonary infiltrates (HP:0002113)2.46396733
75Glioma (HP:0009733)2.45859609
76Autoimmune hemolytic anemia (HP:0001890)2.44803546
77Dysmetria (HP:0001310)2.42619502
78Generalized tonic-clonic seizures (HP:0002069)2.41956284
79Annular pancreas (HP:0001734)2.41361255
80Depression (HP:0000716)2.41240630
81Pulmonary embolism (HP:0002204)2.41136041
82Supranuclear gaze palsy (HP:0000605)2.39906847
83Excessive salivation (HP:0003781)2.39214509
84Drooling (HP:0002307)2.39214509
85Slow saccadic eye movements (HP:0000514)2.38703157
86Impaired vibration sensation in the lower limbs (HP:0002166)2.32854166
87Abnormality of the labia minora (HP:0012880)2.31726718
88Congenital stationary night blindness (HP:0007642)2.30660649
89Hemoptysis (HP:0002105)2.29520924
90Pustule (HP:0200039)2.26258089
91Poor eye contact (HP:0000817)2.25264577
92Viral hepatitis (HP:0006562)2.23783980
93Recurrent bronchitis (HP:0002837)2.22057707
94Leukocytosis (HP:0001974)2.21832473
95Obstructive lung disease (HP:0006536)2.20045010
96Chronic obstructive pulmonary disease (HP:0006510)2.20045010
97Status epilepticus (HP:0002133)2.17984159
98Urethral obstruction (HP:0000796)2.17949192
99Pointed chin (HP:0000307)2.17150203
100Osteomyelitis (HP:0002754)2.14859797
101Urticaria (HP:0001025)2.14202283
102Abnormality of binocular vision (HP:0011514)2.13047448
103Diplopia (HP:0000651)2.13047448
104Lymphopenia (HP:0001888)2.12612154
105Fatigue (HP:0012378)2.11620042
106Bradykinesia (HP:0002067)2.07648529
107Abnormality of T cell physiology (HP:0011840)2.06073662
108Absent speech (HP:0001344)2.05112148
109Hematochezia (HP:0002573)2.03664352
110Heterotopia (HP:0002282)2.03484162
111Peritonitis (HP:0002586)2.02872889
112Panhypogammaglobulinemia (HP:0003139)2.02668354
113Increased CSF protein (HP:0002922)2.02451128
114Obsessive-compulsive behavior (HP:0000722)2.00712801
115Aqueductal stenosis (HP:0002410)2.00521841
116Hypochromic microcytic anemia (HP:0004840)2.00370831
117Scanning speech (HP:0002168)2.00028593
118Chronic diarrhea (HP:0002028)1.99869628
119Hemiparesis (HP:0001269)1.99615206
120Central scotoma (HP:0000603)1.98969801
121Absent frontal sinuses (HP:0002688)1.97149970
122Episodic fever (HP:0001954)1.96982757
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.96960058
124Menstrual irregularities (HP:0000858)1.96538170
125Urinary urgency (HP:0000012)1.95664193
126Stereotypic behavior (HP:0000733)1.95651939
127Papillary thyroid carcinoma (HP:0002895)1.95399134
128Intention tremor (HP:0002080)1.95171954
129Granulocytopenia (HP:0001913)1.94667523
130Agammaglobulinemia (HP:0004432)1.94658145
131Resting tremor (HP:0002322)1.94423758
132Amyotrophic lateral sclerosis (HP:0007354)1.93508047
133Papilledema (HP:0001085)1.93409833
134Verrucae (HP:0200043)1.93232163
135Papilloma (HP:0012740)1.93232163
136Joint swelling (HP:0001386)1.91763011
137Ankle clonus (HP:0011448)1.91429670
138Anorexia (HP:0002039)1.90775124
139Shawl scrotum (HP:0000049)1.90262432
140Gastrointestinal stroma tumor (HP:0100723)1.90124537
141Neoplasm of striated muscle (HP:0009728)1.89941570
142Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89333738
143Hypochromic anemia (HP:0001931)1.88551480
144Abnormal platelet volume (HP:0011876)1.84103904
145Mutism (HP:0002300)1.83007074
146Inappropriate behavior (HP:0000719)1.82174742
147Abnormality of the periventricular white matter (HP:0002518)1.82114603
148Ventricular fibrillation (HP:0001663)1.82040586
149Microcytic anemia (HP:0001935)1.81762713
150Long eyelashes (HP:0000527)1.79220487
151Hypoplastic ischia (HP:0003175)1.79050937
152Insomnia (HP:0100785)1.78333262
153Neuronal loss in central nervous system (HP:0002529)1.77316513
154Hyperacusis (HP:0010780)1.76627111
155Prominent nose (HP:0000448)1.76450591
156Neonatal hypoglycemia (HP:0001998)1.75831373
157Sepsis (HP:0100806)1.75628114
158Attention deficit hyperactivity disorder (HP:0007018)1.75127611
159Vertebral arch anomaly (HP:0008438)1.75013399
160Obstructive sleep apnea (HP:0002870)1.74996550
161Truncal obesity (HP:0001956)1.74492139
162Abnormality of the pleura (HP:0002103)1.74379337
163Exotropia (HP:0000577)1.74014332
164Acne (HP:0001061)1.73032825
165Epileptiform EEG discharges (HP:0011182)1.72818398
166Spastic gait (HP:0002064)1.72631920
167Tetraplegia (HP:0002445)1.72444405
168Abnormality of the endocardium (HP:0004306)1.71534034
169Ankyloglossia (HP:0010296)1.71450314
170Abnormality of the left ventricular outflow tract (HP:0011103)1.71424080
171Subaortic stenosis (HP:0001682)1.71424080
172Vertigo (HP:0002321)1.71088510
173Hand muscle atrophy (HP:0009130)1.70881637
174Amaurosis fugax (HP:0100576)1.68872911
175Eosinophilia (HP:0001880)1.67095918
176Open mouth (HP:0000194)1.66608487
177Distal upper limb amyotrophy (HP:0007149)1.66599765
178Upper limb amyotrophy (HP:0009129)1.66599765
179Impaired vibratory sensation (HP:0002495)1.65878820
180Thickened calvaria (HP:0002684)1.65205963
181Relative macrocephaly (HP:0004482)1.64819447
182Neoplasm of the tracheobronchial system (HP:0100552)1.64753946
183EEG with generalized epileptiform discharges (HP:0011198)1.64677248
184Abnormality of eosinophils (HP:0001879)1.64496579
185Polycythemia (HP:0001901)1.64306055
186Lower limb asymmetry (HP:0100559)1.63813713
187Gangrene (HP:0100758)1.63631696
188Abnormality of the peritoneum (HP:0002585)1.62793240
189Anal stenosis (HP:0002025)1.62368560
190Horizontal nystagmus (HP:0000666)1.59338997
191Abnormality of oral frenula (HP:0000190)1.58602801
192Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58585065
193Narrow palate (HP:0000189)1.57036313

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.58408645
2MAP3K93.41098604
3CDK123.32704526
4EPHA43.02289671
5PRPF4B2.52975891
6PRKD32.25760755
7PAK62.23686765
8TXK2.20441383
9MAP3K42.18853643
10TYK22.06692770
11BLK1.88237317
12CAMK1G1.85255059
13AKT31.81320035
14EEF2K1.79526816
15ERN11.77993178
16CSK1.76449230
17PNCK1.75878930
18IRAK41.74864114
19STK381.73734827
20SIK21.71681095
21NLK1.71456210
22MAP3K131.65104772
23ALK1.64258964
24CAMKK11.63895316
25BTK1.63621870
26RIPK41.61907565
27TYRO31.61262076
28KSR21.60151346
29BRD41.59601229
30ZAP701.57930982
31CAMK1D1.54747712
32MAP2K31.52900253
33EPHB11.52057494
34JAK31.50321906
35FES1.49165264
36SYK1.46150846
37MINK11.42463211
38FGFR41.42204439
39MAP3K141.41623916
40TAOK11.41237455
41MAP2K41.39742407
42MAP3K101.34507323
43DAPK21.34341880
44NTRK21.33999783
45ITK1.33733240
46IKBKE1.28840397
47BMPR21.28108989
48YES11.23413775
49SGK31.23025101
50JAK21.22280600
51ICK1.22260107
52STK111.20222108
53TRPM71.20076250
54FRK1.14364662
55MAP4K11.12563218
56KSR11.11391615
57FGR1.10451148
58MAP3K71.08568560
59RIPK11.08045003
60CDK51.03884321
61CDC42BPA1.03162584
62SIK31.01209949
63PRKCH1.01063771
64CSF1R1.00670663
65LCK1.00528679
66TEC0.99982119
67GRK60.97022028
68MAPK100.96725784
69SGK20.96021581
70TRIB30.95995638
71PDK10.95408613
72RAF10.95348274
73PRKD20.94558874
74RET0.94359668
75PIK3CG0.91978852
76LYN0.91274855
77WNK10.91051311
78EPHA30.90424600
79DAPK10.90095355
80MARK20.89887433
81TNK20.89078666
82NTRK10.88354393
83GRK50.87360336
84CAMK10.86939928
85MAP3K20.86454100
86MARK10.86264036
87NEK10.86171579
88MAP2K70.84628159
89IRAK10.78863379
90LATS10.78081676
91SGK10.75490803
92CAMKK20.73872337
93SCYL20.71691243
94MAP3K60.71114775
95CAMK40.70257168
96DYRK1A0.67748861
97PDGFRB0.63743905
98MAP3K30.63417690
99RPS6KA30.62664345
100MTOR0.60676502
101PDPK10.58577140
102GSK3B0.58498748
103KIT0.57689072
104PRKCQ0.57484644
105PRKAA10.56612573
106MAP3K10.56098480
107SGK2230.55998147
108SGK4940.55998147
109TBK10.55892028
110HIPK20.55466831
111TAOK30.54876246
112PTK2B0.54159910
113LATS20.54042778
114IRAK20.53882095
115LRRK20.53359758
116PKN20.53049147
117CSNK1E0.51906867
118CSNK1D0.51596237
119MAPK130.51279192
120SMG10.51201687
121FGFR20.50763282
122PRKCG0.50038522
123CDK20.49854482
124IKBKB0.49738193
125STK100.49641657
126SIK10.49555415
127MELK0.49530602
128STK240.48841836
129HCK0.48513142
130FGFR30.48237109
131MAPK80.46606318
132PRKAA20.46501197
133MAPK120.46492238
134MAPK110.46260483
135CDK60.46117702
136PTK60.45844897
137MAPK140.44020397
138CDK90.44001902
139CHEK10.43474922
140MARK30.42669875
141PRKDC0.41865047
142RPS6KB10.41553874
143JAK10.41174874
144BRSK10.40470994
145NEK20.38349627
146MAPK70.37996416
147CSNK1G20.37360584
148PINK10.37009319
149BMX0.35918893
150FYN0.35747996
151CDK150.34248004

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.75687240
2Long-term potentiation_Homo sapiens_hsa047202.58389367
3Olfactory transduction_Homo sapiens_hsa047402.33767492
4Circadian entrainment_Homo sapiens_hsa047132.22774233
5Glutamatergic synapse_Homo sapiens_hsa047242.18316755
6GABAergic synapse_Homo sapiens_hsa047272.11418333
7Amphetamine addiction_Homo sapiens_hsa050312.08475037
8Osteoclast differentiation_Homo sapiens_hsa043802.07970628
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04198264
10Morphine addiction_Homo sapiens_hsa050322.02161672
11Salivary secretion_Homo sapiens_hsa049702.01470283
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98488632
13Synaptic vesicle cycle_Homo sapiens_hsa047211.98410163
14Insulin secretion_Homo sapiens_hsa049111.82424449
15Leishmaniasis_Homo sapiens_hsa051401.82028789
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81392871
17Dopaminergic synapse_Homo sapiens_hsa047281.72547055
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.62367731
19Primary immunodeficiency_Homo sapiens_hsa053401.60343671
20Nitrogen metabolism_Homo sapiens_hsa009101.60174350
21Gastric acid secretion_Homo sapiens_hsa049711.59562524
22Renin secretion_Homo sapiens_hsa049241.58491512
23Measles_Homo sapiens_hsa051621.57572047
24Oxytocin signaling pathway_Homo sapiens_hsa049211.53929170
25Taste transduction_Homo sapiens_hsa047421.49641570
26Type II diabetes mellitus_Homo sapiens_hsa049301.47454344
27Long-term depression_Homo sapiens_hsa047301.46941195
28Cholinergic synapse_Homo sapiens_hsa047251.43951407
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43687218
30Tuberculosis_Homo sapiens_hsa051521.40659995
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40328516
32GnRH signaling pathway_Homo sapiens_hsa049121.39539206
33Cocaine addiction_Homo sapiens_hsa050301.39011841
34mTOR signaling pathway_Homo sapiens_hsa041501.38414066
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.35675288
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34657712
37Staphylococcus aureus infection_Homo sapiens_hsa051501.33373954
38Pancreatic cancer_Homo sapiens_hsa052121.31419219
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.28388076
40Calcium signaling pathway_Homo sapiens_hsa040201.27348724
41Graft-versus-host disease_Homo sapiens_hsa053321.26762726
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25118965
43cAMP signaling pathway_Homo sapiens_hsa040241.23116161
44Estrogen signaling pathway_Homo sapiens_hsa049151.22865208
45Phototransduction_Homo sapiens_hsa047441.22405456
46Dorso-ventral axis formation_Homo sapiens_hsa043201.22383205
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22077424
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19235034
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.18978023
50Type I diabetes mellitus_Homo sapiens_hsa049401.18535502
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17865203
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17838318
53Hepatitis B_Homo sapiens_hsa051611.17400023
54Toxoplasmosis_Homo sapiens_hsa051451.16642079
55Autoimmune thyroid disease_Homo sapiens_hsa053201.13664072
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12974687
57Allograft rejection_Homo sapiens_hsa053301.12284604
58Gap junction_Homo sapiens_hsa045401.10858067
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08145718
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08080359
61Hematopoietic cell lineage_Homo sapiens_hsa046401.07675370
62Inositol phosphate metabolism_Homo sapiens_hsa005621.07640561
63Malaria_Homo sapiens_hsa051441.07634242
64Glioma_Homo sapiens_hsa052141.07003282
65Influenza A_Homo sapiens_hsa051641.06692917
66ErbB signaling pathway_Homo sapiens_hsa040121.05486333
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05017937
68Serotonergic synapse_Homo sapiens_hsa047261.03797294
69TNF signaling pathway_Homo sapiens_hsa046681.03390093
70MAPK signaling pathway_Homo sapiens_hsa040101.03024646
71Hepatitis C_Homo sapiens_hsa051601.02077104
72B cell receptor signaling pathway_Homo sapiens_hsa046620.97536137
73Oocyte meiosis_Homo sapiens_hsa041140.95941805
74Prostate cancer_Homo sapiens_hsa052150.95584289
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95170239
76Non-small cell lung cancer_Homo sapiens_hsa052230.93428588
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93275601
78Choline metabolism in cancer_Homo sapiens_hsa052310.92766147
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.92531586
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91966815
81Herpes simplex infection_Homo sapiens_hsa051680.91618467
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.89948227
83Pancreatic secretion_Homo sapiens_hsa049720.89101793
84Viral myocarditis_Homo sapiens_hsa054160.87454988
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85561915
86VEGF signaling pathway_Homo sapiens_hsa043700.85545797
87Glucagon signaling pathway_Homo sapiens_hsa049220.85178932
88Circadian rhythm_Homo sapiens_hsa047100.80459164
89Antigen processing and presentation_Homo sapiens_hsa046120.80238328
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79670698
91Thyroid cancer_Homo sapiens_hsa052160.79659349
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.79358455
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.76760657
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76274451
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76185445
96Thyroid hormone synthesis_Homo sapiens_hsa049180.74160868
97Endometrial cancer_Homo sapiens_hsa052130.73292937
98Melanogenesis_Homo sapiens_hsa049160.71870424
99Bile secretion_Homo sapiens_hsa049760.71652340
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69275444
101T cell receptor signaling pathway_Homo sapiens_hsa046600.68830058
102Apoptosis_Homo sapiens_hsa042100.67057326
103Legionellosis_Homo sapiens_hsa051340.65755051
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64831118
105Insulin signaling pathway_Homo sapiens_hsa049100.63933700
106Dilated cardiomyopathy_Homo sapiens_hsa054140.63712069
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63451130
108Rap1 signaling pathway_Homo sapiens_hsa040150.63418435
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62781942
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.62458074
111Chemokine signaling pathway_Homo sapiens_hsa040620.61401209
112Colorectal cancer_Homo sapiens_hsa052100.61012578
113Lysine degradation_Homo sapiens_hsa003100.60918925
114Chronic myeloid leukemia_Homo sapiens_hsa052200.60757354
115Renal cell carcinoma_Homo sapiens_hsa052110.60271259
116African trypanosomiasis_Homo sapiens_hsa051430.58848810
117HIF-1 signaling pathway_Homo sapiens_hsa040660.57551236
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57528340
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56086014
120Platelet activation_Homo sapiens_hsa046110.54871805
121Viral carcinogenesis_Homo sapiens_hsa052030.54687093
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53792733
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53402023
124Phagosome_Homo sapiens_hsa041450.53168456
125Wnt signaling pathway_Homo sapiens_hsa043100.52386815
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52006126
127Shigellosis_Homo sapiens_hsa051310.51680064
128Amoebiasis_Homo sapiens_hsa051460.51255233
129mRNA surveillance pathway_Homo sapiens_hsa030150.51159991
130Endocytosis_Homo sapiens_hsa041440.50231158
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50209899
132Axon guidance_Homo sapiens_hsa043600.49644542
133Notch signaling pathway_Homo sapiens_hsa043300.49208936
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48718815
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.47455692
136Ras signaling pathway_Homo sapiens_hsa040140.46487731
137FoxO signaling pathway_Homo sapiens_hsa040680.46289337
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.44523881
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43679423
140Insulin resistance_Homo sapiens_hsa049310.43253246
141Acute myeloid leukemia_Homo sapiens_hsa052210.41945132
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41613478
143Prolactin signaling pathway_Homo sapiens_hsa049170.41155612
144AMPK signaling pathway_Homo sapiens_hsa041520.39118408
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38377455

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