GLUD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.02328334
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.02328334
3L-phenylalanine metabolic process (GO:0006558)6.80530234
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.80530234
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.31340646
6aromatic amino acid family catabolic process (GO:0009074)6.23820088
7alpha-linolenic acid metabolic process (GO:0036109)5.96092102
8glyoxylate metabolic process (GO:0046487)5.65157415
9kynurenine metabolic process (GO:0070189)5.64472502
10cysteine metabolic process (GO:0006534)5.63269427
11tryptophan catabolic process (GO:0006569)5.57023419
12indole-containing compound catabolic process (GO:0042436)5.57023419
13indolalkylamine catabolic process (GO:0046218)5.57023419
14bile acid biosynthetic process (GO:0006699)5.47722905
15urea cycle (GO:0000050)5.40347803
16urea metabolic process (GO:0019627)5.40347803
17negative regulation of fibrinolysis (GO:0051918)5.33345387
18sulfur amino acid catabolic process (GO:0000098)5.31616640
19high-density lipoprotein particle remodeling (GO:0034375)5.27549916
20tryptophan metabolic process (GO:0006568)5.24983820
21serine family amino acid catabolic process (GO:0009071)5.13860114
22lysine catabolic process (GO:0006554)5.07398219
23lysine metabolic process (GO:0006553)5.07398219
24peptidyl-glutamic acid carboxylation (GO:0017187)5.00694754
25protein carboxylation (GO:0018214)5.00694754
26regulation of protein activation cascade (GO:2000257)5.00025696
27complement activation, alternative pathway (GO:0006957)4.98864079
28regulation of fibrinolysis (GO:0051917)4.97824705
29nitrogen cycle metabolic process (GO:0071941)4.92634843
30homocysteine metabolic process (GO:0050667)4.91234248
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90305603
32reverse cholesterol transport (GO:0043691)4.86614016
33regulation of cholesterol esterification (GO:0010872)4.78159592
34regulation of triglyceride catabolic process (GO:0010896)4.75553477
35plasma lipoprotein particle remodeling (GO:0034369)4.73664418
36protein-lipid complex remodeling (GO:0034368)4.73664418
37macromolecular complex remodeling (GO:0034367)4.73664418
38amino-acid betaine metabolic process (GO:0006577)4.68898028
39regulation of complement activation (GO:0030449)4.67758454
40bile acid metabolic process (GO:0008206)4.67633171
41glycine metabolic process (GO:0006544)4.54226270
42* alpha-amino acid catabolic process (GO:1901606)4.52222662
43negative regulation of sterol transport (GO:0032372)4.51890817
44negative regulation of cholesterol transport (GO:0032375)4.51890817
45aromatic amino acid family metabolic process (GO:0009072)4.49094166
46cellular modified amino acid catabolic process (GO:0042219)4.47395417
47phospholipid efflux (GO:0033700)4.45008201
48serine family amino acid metabolic process (GO:0009069)4.42849156
49plasma lipoprotein particle clearance (GO:0034381)4.41818751
50serine family amino acid biosynthetic process (GO:0009070)4.40406220
51* glutamate metabolic process (GO:0006536)4.39210102
52cellular ketone body metabolic process (GO:0046950)4.30206330
53triglyceride homeostasis (GO:0070328)4.27545904
54acylglycerol homeostasis (GO:0055090)4.27545904
55tyrosine metabolic process (GO:0006570)4.26856308
56* cellular amino acid catabolic process (GO:0009063)4.25529687
57low-density lipoprotein particle remodeling (GO:0034374)4.24187264
58regulation of cholesterol biosynthetic process (GO:0045540)4.20465482
59plasma lipoprotein particle assembly (GO:0034377)4.14087839
60ethanol oxidation (GO:0006069)4.09153643
61cellular glucuronidation (GO:0052695)4.06303279
62* dicarboxylic acid biosynthetic process (GO:0043650)4.01953289
63regulation of cholesterol homeostasis (GO:2000188)4.01523019
64cholesterol efflux (GO:0033344)4.01174218
65imidazole-containing compound metabolic process (GO:0052803)3.98278197
66coenzyme catabolic process (GO:0009109)3.92327594
67aspartate family amino acid catabolic process (GO:0009068)3.89277602
68indolalkylamine metabolic process (GO:0006586)3.88637978
69phospholipid homeostasis (GO:0055091)3.87531567
70bile acid and bile salt transport (GO:0015721)3.87189271
71short-chain fatty acid metabolic process (GO:0046459)3.82071965
72drug catabolic process (GO:0042737)3.81447825
73positive regulation of lipid catabolic process (GO:0050996)3.79079191
74protein-lipid complex assembly (GO:0065005)3.79050409
75regulation of plasminogen activation (GO:0010755)3.75665705
76arginine metabolic process (GO:0006525)3.75267563
77fibrinolysis (GO:0042730)3.74555090
78regulation of apoptotic cell clearance (GO:2000425)3.74505994
79benzene-containing compound metabolic process (GO:0042537)3.73684682
80plasma lipoprotein particle organization (GO:0071827)3.73544300
81very-low-density lipoprotein particle assembly (GO:0034379)3.72734608
82amine catabolic process (GO:0009310)3.71329468
83cellular biogenic amine catabolic process (GO:0042402)3.71329468
842-oxoglutarate metabolic process (GO:0006103)3.71111692
85acetyl-CoA metabolic process (GO:0006084)3.68444221
86ketone body metabolic process (GO:1902224)3.67899346
87* carboxylic acid catabolic process (GO:0046395)3.67445246
88* organic acid catabolic process (GO:0016054)3.67445246
89urate metabolic process (GO:0046415)3.65654024
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.63988486
91intestinal cholesterol absorption (GO:0030299)3.63063781
92cholesterol homeostasis (GO:0042632)3.62488515
93sterol homeostasis (GO:0055092)3.59831546
94carnitine metabolic process (GO:0009437)3.56645294
95protein-lipid complex subunit organization (GO:0071825)3.55815698
96lipoprotein metabolic process (GO:0042157)3.55142397
97uronic acid metabolic process (GO:0006063)3.54554087
98glucuronate metabolic process (GO:0019585)3.54554087
99positive regulation of extracellular matrix organization (GO:1903055)3.54262332
100regulation of bile acid biosynthetic process (GO:0070857)3.53427788
101L-serine metabolic process (GO:0006563)3.52167577
102positive regulation of triglyceride lipase activity (GO:0061365)3.51515261
103positive regulation of lipoprotein lipase activity (GO:0051006)3.51515261
104proline metabolic process (GO:0006560)3.50102039
105Golgi transport vesicle coating (GO:0048200)3.48162553
106COPI coating of Golgi vesicle (GO:0048205)3.48162553
107blood coagulation, intrinsic pathway (GO:0007597)3.47440759
108positive regulation of triglyceride metabolic process (GO:0090208)3.44837024
109aldehyde catabolic process (GO:0046185)3.44390179
110proline biosynthetic process (GO:0006561)3.36966774
111regulation of cholesterol metabolic process (GO:0090181)3.33529018
112positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.33347834
113epoxygenase P450 pathway (GO:0019373)3.29460459
114negative regulation of lipid transport (GO:0032369)3.23991082
115amino acid import (GO:0043090)3.14622927
116* glutamine family amino acid biosynthetic process (GO:0009084)3.14578352
117sodium ion export (GO:0071436)3.12807477
118negative regulation of lipase activity (GO:0060192)3.11702699
119positive regulation of steroid metabolic process (GO:0045940)3.10110126
120negative regulation of protein activation cascade (GO:2000258)3.07037094
121low-density lipoprotein particle clearance (GO:0034383)3.04060076
122regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.01383488
123positive regulation of fatty acid biosynthetic process (GO:0045723)2.97751610
124positive regulation of blood coagulation (GO:0030194)2.95148999
125positive regulation of hemostasis (GO:1900048)2.95148999
126regulation of extracellular matrix organization (GO:1903053)2.94227252
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.92799034
128protein retention in ER lumen (GO:0006621)2.92609182
129acute-phase response (GO:0006953)2.92054909
130L-amino acid import (GO:0043092)2.91699344
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.91378960
132lipoprotein transport (GO:0042953)2.90100276
133negative regulation of hemostasis (GO:1900047)2.89606368
134negative regulation of blood coagulation (GO:0030195)2.89606368
135protein activation cascade (GO:0072376)2.88241316
136COPII vesicle coating (GO:0048208)2.87633200
137ethanol metabolic process (GO:0006067)2.87582269
138cellular sodium ion homeostasis (GO:0006883)2.86981040
139negative regulation of fatty acid transport (GO:2000192)2.84552741
140response to mercury ion (GO:0046689)2.82544897
141intestinal absorption (GO:0050892)2.82351426
142retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.80986011
143complement activation, classical pathway (GO:0006958)2.79466581
144positive regulation of coagulation (GO:0050820)2.79029261
145embryonic retina morphogenesis in camera-type eye (GO:0060059)2.78913579
146sterol transport (GO:0015918)2.78755145
147cholesterol transport (GO:0030301)2.78755145
148cellular potassium ion homeostasis (GO:0030007)2.78052311
149omega-hydroxylase P450 pathway (GO:0097267)2.72147809
150diacylglycerol metabolic process (GO:0046339)2.70495705
151acylglycerol catabolic process (GO:0046464)2.69833640
152neutral lipid catabolic process (GO:0046461)2.69833640
153negative regulation of coagulation (GO:0050819)2.64510761
154regulation of humoral immune response (GO:0002920)2.64327946
155regulation of fatty acid biosynthetic process (GO:0042304)2.63321846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.92176709
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.90652891
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.22649131
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.88251732
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.26231080
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.77507335
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.21925192
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.83915038
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.81221991
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.33535727
11CLOCK_20551151_ChIP-Seq_293T_Human2.30840214
12* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29722822
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.18475435
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4635774
15ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89409822
16* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88962629
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87865529
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.87232923
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.80376190
20* FOXA2_19822575_ChIP-Seq_HepG2_Human1.75465233
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74729056
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68583223
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55493077
24* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48419996
25KDM2B_26808549_Chip-Seq_K562_Human1.47414322
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47100536
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46758219
28GATA1_22025678_ChIP-Seq_K562_Human1.45021044
29* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44358876
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37769448
31CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36589362
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35782754
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34178998
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33358335
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29874160
36* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26801442
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.26705572
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26174552
39ZNF263_19887448_ChIP-Seq_K562_Human1.26019621
40TCF7_22412390_ChIP-Seq_EML_Mouse1.25929730
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23315024
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22072796
43* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20954813
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18248293
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.17434105
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15832608
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15688547
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15251297
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15154774
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12415107
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11788453
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11006386
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10975159
54* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10844243
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.10727858
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10486853
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09474508
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08954048
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06492027
60* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02653281
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01426072
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00495195
63EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00138373
64HTT_18923047_ChIP-ChIP_STHdh_Human0.99821913
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98840746
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97836853
67RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97516649
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97251773
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94849431
70KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94224572
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93819577
72* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92882899
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92591601
74* UBF1/2_26484160_Chip-Seq_HMECs_Human0.92450764
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91599642
76FOXO3_23340844_ChIP-Seq_DLD1_Human0.91244179
77GATA4_25053715_ChIP-Seq_YYC3_Human0.91200884
78* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89916015
79* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89683945
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89587407
81MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89303734
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89240907
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88690367
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87730040
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87560958
86LXR_22292898_ChIP-Seq_THP-1_Human0.85354302
87IRF8_22096565_ChIP-ChIP_GC-B_Human0.84624736
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82927465
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79406585
90ESR1_21235772_ChIP-Seq_MCF-7_Human0.74425633
91PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73573323
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72816006
93* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71250164
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71235329
95TRIM28_21343339_ChIP-Seq_HEK293_Human0.70630704
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69548312
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69548312
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66973639
99GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.66810011
100RACK7_27058665_Chip-Seq_MCF-7_Human0.66738401
101GATA6_25053715_ChIP-Seq_YYC3_Human0.66435462
102AR_21909140_ChIP-Seq_LNCAP_Human0.65671479
103* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.65546364
104GATA1_19941826_ChIP-Seq_K562_Human0.64031477
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63789997
106CDX2_20551321_ChIP-Seq_CACO-2_Human0.62740958
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.62503438
108* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62311127
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60261904
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59723206
111RARA_24833708_ChIP-Seq_LIVER_Mouse0.59213843
112BRD4_27068464_Chip-Seq_AML-cells_Mouse0.56704100
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.56656093
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.56573207
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.53541251
116GATA2_19941826_ChIP-Seq_K562_Human0.53297812
117POU5F1_16518401_ChIP-PET_MESCs_Mouse0.52560341
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.52439054
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.52017714
120* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.51603419
121* NANOG_16518401_ChIP-PET_MESCs_Mouse0.51284395
122EGR1_19032775_ChIP-ChIP_M12_Human0.50641861
123* ATF3_27146783_Chip-Seq_COLON_Human0.49661319
124CREB1_26743006_Chip-Seq_LNCaP_Human0.49543377
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.48911458
126* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48889509
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.48828436
128* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.48065837
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.47991147
130* FOXA1_25552417_ChIP-Seq_VCAP_Human0.47754139
131GATA3_24758297_ChIP-Seq_MCF-7_Human0.47707418
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.47681039
133* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.46526844
134* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.46066584
135* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.44913612
136* TBX20_22328084_ChIP-Seq_HEART_Mouse0.44807142
137* TBX20_22080862_ChIP-Seq_HEART_Mouse0.44807142
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.44622827
139CEBPB_22108803_ChIP-Seq_LS180_Human0.44332044
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.43968962
141SOX2_20726797_ChIP-Seq_SW620_Human0.43559627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.90102457
2MP0005360_urolithiasis7.47649629
3MP0005085_abnormal_gallbladder_physiolo5.90410567
4MP0005365_abnormal_bile_salt5.85872169
5MP0008875_abnormal_xenobiotic_pharmacok4.62775371
6MP0003806_abnormal_nucleotide_metabolis4.26728317
7MP0003252_abnormal_bile_duct3.90018398
8MP0010329_abnormal_lipoprotein_level3.57541381
9MP0009840_abnormal_foam_cell3.43594146
10MP0005332_abnormal_amino_acid3.01215524
11MP0005083_abnormal_biliary_tract2.91423569
12MP0009780_abnormal_chondrocyte_physiolo2.72249617
13MP0001666_abnormal_nutrient_absorption2.54423679
14MP0003195_calcinosis2.51325808
15MP0003191_abnormal_cellular_cholesterol2.32591692
16MP0004019_abnormal_vitamin_homeostasis2.30894945
17MP0005409_darkened_coat_color2.16502857
18MP0000609_abnormal_liver_physiology2.16455302
19MP0003705_abnormal_hypodermis_morpholog2.15347162
20MP0002138_abnormal_hepatobiliary_system2.10902717
21MP0002118_abnormal_lipid_homeostasis2.09373940
22MP0000920_abnormal_myelination1.87995361
23MP0004270_analgesia1.87646530
24MP0005319_abnormal_enzyme/_coenzyme1.79713200
25MP0003868_abnormal_feces_composition1.76177420
26MP0000566_synostosis1.68673795
27MP0002877_abnormal_melanocyte_morpholog1.60964098
28MP0004272_abnormal_basement_membrane1.60391475
29MP0008438_abnormal_cutaneous_collagen1.58917034
30* MP0005584_abnormal_enzyme/coenzyme_acti1.56511166
31MP0002089_abnormal_postnatal_growth/wei1.48570852
32MP0009643_abnormal_urine_homeostasis1.45133271
33MP0003186_abnormal_redox_activity1.37928724
34MP0004858_abnormal_nervous_system1.37787067
35MP0002254_reproductive_system_inflammat1.36064786
36MP0009697_abnormal_copulation1.35761749
37MP0003122_maternal_imprinting1.35422882
38MP0003091_abnormal_cell_migration1.34151574
39MP0003183_abnormal_peptide_metabolism1.33695232
40MP0001764_abnormal_homeostasis1.32804145
41MP0005257_abnormal_intraocular_pressure1.30207804
42MP0003634_abnormal_glial_cell1.30147151
43MP0005076_abnormal_cell_differentiation1.28862946
44MP0003632_abnormal_nervous_system1.23741255
45MP0000604_amyloidosis1.22604421
46MP0000598_abnormal_liver_morphology1.20955076
47MP0008260_abnormal_autophagy1.17068452
48MP0004859_abnormal_synaptic_plasticity1.15428592
49MP0001849_ear_inflammation1.10936786
50MP0003879_abnormal_hair_cell1.10719086
51MP0003123_paternal_imprinting1.08044175
52MP0003690_abnormal_glial_cell1.07917368
53MP0003011_delayed_dark_adaptation1.07250661
54MP0003656_abnormal_erythrocyte_physiolo1.05476744
55MP0002896_abnormal_bone_mineralization1.03857742
56MP0004130_abnormal_muscle_cell1.01821616
57MP0009764_decreased_sensitivity_to0.98963105
58MP0003633_abnormal_nervous_system0.98413192
59MP0005670_abnormal_white_adipose0.98166428
60MP0002009_preneoplasia0.97701876
61MP0009763_increased_sensitivity_to0.95779303
62MP0005647_abnormal_sex_gland0.95181778
63MP0003631_nervous_system_phenotype0.91717722
64MP0005451_abnormal_body_composition0.90994137
65MP0005636_abnormal_mineral_homeostasis0.90678723
66MP0010368_abnormal_lymphatic_system0.89806230
67MP0003941_abnormal_skin_development0.86437023
68MP0009053_abnormal_anal_canal0.85878450
69MP0000747_muscle_weakness0.82562662
70MP0001756_abnormal_urination0.82560946
71MP0003300_gastrointestinal_ulcer0.82040411
72MP0004233_abnormal_muscle_weight0.81668043
73* MP0009642_abnormal_blood_homeostasis0.81563409
74MP0002971_abnormal_brown_adipose0.81134343
75MP0003075_altered_response_to0.80596738
76MP0000537_abnormal_urethra_morphology0.80450001
77MP0003329_amyloid_beta_deposits0.80360376
78MP0005666_abnormal_adipose_tissue0.79729628
79MP0008469_abnormal_protein_level0.79386812
80MP0005623_abnormal_meninges_morphology0.77467808
81MP0001958_emphysema0.77420600
82MP0003950_abnormal_plasma_membrane0.77290854
83* MP0002078_abnormal_glucose_homeostasis0.76875070
84MP0000003_abnormal_adipose_tissue0.75816018
85MP0001730_embryonic_growth_arrest0.73353730
86MP0005220_abnormal_exocrine_pancreas0.72646450
87MP0005376_homeostasis/metabolism_phenot0.72358947
88MP0008569_lethality_at_weaning0.71438059
89MP0005084_abnormal_gallbladder_morpholo0.71262967
90MP0010234_abnormal_vibrissa_follicle0.71240912
91MP0005167_abnormal_blood-brain_barrier0.70866953
92MP0002166_altered_tumor_susceptibility0.70817333
93MP0003315_abnormal_perineum_morphology0.68982894
94MP0005165_increased_susceptibility_to0.68534255
95MP0005334_abnormal_fat_pad0.68399506
96MP0002136_abnormal_kidney_physiology0.68179197
97MP0002909_abnormal_adrenal_gland0.68118516
98MP0009765_abnormal_xenobiotic_induced0.66287389
99MP0005266_abnormal_metabolism0.65350947
100MP0006036_abnormal_mitochondrial_physio0.64910521
101MP0005166_decreased_susceptibility_to0.64313927
102MP0005535_abnormal_body_temperature0.63969562
103MP0002060_abnormal_skin_morphology0.62803443
104MP0005058_abnormal_lysosome_morphology0.62718169
105MP0005621_abnormal_cell_physiology0.61998689
106MP0000858_altered_metastatic_potential0.60544579
107MP0006054_spinal_hemorrhage0.58348959
108MP0003638_abnormal_response/metabolism_0.58011349
109MP0009384_cardiac_valve_regurgitation0.57064808
110MP0005408_hypopigmentation0.56778928
111MP0010630_abnormal_cardiac_muscle0.54500511
112MP0004782_abnormal_surfactant_physiolog0.54340554
113MP0005448_abnormal_energy_balance0.53646187
114MP0004185_abnormal_adipocyte_glucose0.53562130
115MP0001851_eye_inflammation0.52831966
116MP0005423_abnormal_somatic_nervous0.52739611
117MP0009672_abnormal_birth_weight0.51958700
118MP0005248_abnormal_Harderian_gland0.51709252
119MP0001661_extended_life_span0.51352885
120MP0005464_abnormal_platelet_physiology0.50992388
121MP0002168_other_aberrant_phenotype0.49917719
122MP0000639_abnormal_adrenal_gland0.49558344
123MP0005395_other_phenotype0.48331981
124MP0001853_heart_inflammation0.47643563
125MP0002928_abnormal_bile_duct0.47602971
126MP0003436_decreased_susceptibility_to0.44423409
127MP0009115_abnormal_fat_cell0.43747929
128MP0008874_decreased_physiological_sensi0.43373085
129MP0002796_impaired_skin_barrier0.43292812
130MP0004043_abnormal_pH_regulation0.41844797
131MP0005023_abnormal_wound_healing0.39324371
132MP0000579_abnormal_nail_morphology0.39194148
133MP0008873_increased_physiological_sensi0.39034552
134MP0001915_intracranial_hemorrhage0.38858115
135* MP0003953_abnormal_hormone_level0.37523517
136MP0000249_abnormal_blood_vessel0.37453745
137MP0002970_abnormal_white_adipose0.36593086
138MP0003566_abnormal_cell_adhesion0.35992323
139MP0001881_abnormal_mammary_gland0.35318059
140MP0004264_abnormal_extraembryonic_tissu0.35182571
141MP0004883_abnormal_blood_vessel0.35111980
142MP0008961_abnormal_basal_metabolism0.34853284
143MP0010352_gastrointestinal_tract_polyps0.34651221
144MP0003453_abnormal_keratinocyte_physiol0.33371335
145MP0002135_abnormal_kidney_morphology0.33322515
146MP0005375_adipose_tissue_phenotype0.33193293
147MP0003172_abnormal_lysosome_physiology0.32267572
148MP0001765_abnormal_ion_homeostasis0.32026242

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.02949970
2Intrahepatic cholestasis (HP:0001406)6.85073980
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.67475742
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.30196132
5Xanthomatosis (HP:0000991)6.26191113
6Hypobetalipoproteinemia (HP:0003563)5.96851226
7Prolonged partial thromboplastin time (HP:0003645)5.52347145
8Hyperlipoproteinemia (HP:0010980)5.25297984
9Complement deficiency (HP:0004431)4.93610224
10Hypolipoproteinemia (HP:0010981)4.73527816
11* Hyperammonemia (HP:0001987)4.54557216
12Hyperglycinemia (HP:0002154)4.54194661
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.52072253
14Hyperglycinuria (HP:0003108)4.45130047
15Abnormality of serine family amino acid metabolism (HP:0010894)4.33578330
16Abnormality of glycine metabolism (HP:0010895)4.33578330
17Epidermoid cyst (HP:0200040)4.33223446
18Hypoalphalipoproteinemia (HP:0003233)4.32119727
19Ketosis (HP:0001946)4.31530533
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.30317171
21Abnormality of the common coagulation pathway (HP:0010990)4.22487940
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.18892876
23Joint hemorrhage (HP:0005261)4.18170818
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.00299313
25Abnormality of methionine metabolism (HP:0010901)3.88522082
26Fat malabsorption (HP:0002630)3.78441380
27Abnormality of complement system (HP:0005339)3.66927756
28Abnormality of pyrimidine metabolism (HP:0004353)3.55586348
29Hypercholesterolemia (HP:0003124)3.43011443
30* Hypoglycemic coma (HP:0001325)3.32054006
31Abnormality of the intrinsic pathway (HP:0010989)3.29055657
32Ketoacidosis (HP:0001993)3.27253068
33Delayed CNS myelination (HP:0002188)3.26394132
34Abnormality of fatty-acid metabolism (HP:0004359)3.24777290
35Conjugated hyperbilirubinemia (HP:0002908)3.20026589
36Myocardial infarction (HP:0001658)3.18425567
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.14487250
38Neurofibrillary tangles (HP:0002185)3.08791971
39Abnormality of nucleobase metabolism (HP:0010932)3.08128179
40Hyperbilirubinemia (HP:0002904)3.04900712
41Spastic diplegia (HP:0001264)3.03943709
42Abnormality of serum amino acid levels (HP:0003112)2.99955052
43Hepatocellular carcinoma (HP:0001402)2.94442614
44Gout (HP:0001997)2.86850807
45Skin nodule (HP:0200036)2.84495337
46Abnormality of purine metabolism (HP:0004352)2.84399095
47Scanning speech (HP:0002168)2.75855430
48Steatorrhea (HP:0002570)2.73137010
49Esophageal varix (HP:0002040)2.71287689
50Abnormality of carpal bone ossification (HP:0006257)2.69862102
51Protrusio acetabuli (HP:0003179)2.68595740
52Systemic lupus erythematosus (HP:0002725)2.67853884
53Cerebral inclusion bodies (HP:0100314)2.64936449
54Vascular calcification (HP:0004934)2.63903222
55Flat acetabular roof (HP:0003180)2.62317480
56Spontaneous abortion (HP:0005268)2.61753520
57Metabolic acidosis (HP:0001942)2.60326291
58Acanthocytosis (HP:0001927)2.47541643
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46134955
60Dicarboxylic aciduria (HP:0003215)2.46134955
61Neonatal onset (HP:0003623)2.45961400
62Cardiovascular calcification (HP:0011915)2.41348897
63Abnormality of proline metabolism (HP:0010907)2.40297168
64Hydroxyprolinuria (HP:0003080)2.40297168
65Hypochromic microcytic anemia (HP:0004840)2.39822280
66Sensorimotor neuropathy (HP:0007141)2.39520501
67Amyloidosis (HP:0011034)2.36661071
68Late onset (HP:0003584)2.32024516
69Lethargy (HP:0001254)2.31419483
70Irritability (HP:0000737)2.28893926
71Abnormal ossification of hand bones (HP:0005921)2.27937998
72Malnutrition (HP:0004395)2.27854039
73Glomerulonephritis (HP:0000099)2.21846606
74Recurrent gram-negative bacterial infections (HP:0005420)2.21590909
75Mitral stenosis (HP:0001718)2.20927091
76Hemorrhage of the eye (HP:0011885)2.17876145
77Asymmetry of the thorax (HP:0001555)2.17822036
78Vertebral compression fractures (HP:0002953)2.16991185
79Thrombophlebitis (HP:0004418)2.14687948
80Pancreatitis (HP:0001733)2.13991970
81Back pain (HP:0003418)2.11831070
82Abnormal gallbladder morphology (HP:0012437)2.10522335
83Gingival bleeding (HP:0000225)2.09121765
84Abnormal cartilage morphology (HP:0002763)2.08849994
85Cholelithiasis (HP:0001081)2.07841323
86Enlarged kidneys (HP:0000105)2.04354954
87Abnormal tarsal ossification (HP:0008369)2.03713828
88Ankyloglossia (HP:0010296)2.01214764
89Termporal pattern (HP:0011008)2.00749740
90Insidious onset (HP:0003587)2.00749740
91Status epilepticus (HP:0002133)1.99789518
92Abnormal hand bone ossification (HP:0010660)1.99349222
93Alkalosis (HP:0001948)1.98544647
94Increased purine levels (HP:0004368)1.93977889
95Hyperuricemia (HP:0002149)1.93977889
96Rickets (HP:0002748)1.93828711
97Cholecystitis (HP:0001082)1.91718146
98Abnormal gallbladder physiology (HP:0012438)1.91718146
99Generalized aminoaciduria (HP:0002909)1.90454048
100Neonatal death (HP:0003811)1.89431244
101Vomiting (HP:0002013)1.88728239
102Aplasia involving bones of the upper limbs (HP:0009823)1.88622301
103Aplasia of the phalanges of the hand (HP:0009802)1.88622301
104Aplasia involving bones of the extremities (HP:0009825)1.88622301
105Alacrima (HP:0000522)1.87081999
106Abnormality of the Achilles tendon (HP:0005109)1.86674862
107Menorrhagia (HP:0000132)1.85787847
108Pseudobulbar signs (HP:0002200)1.85163653
109Abnormality of the lumbar spine (HP:0100712)1.84767848
110Poikilocytosis (HP:0004447)1.83100982
111Proximal tubulopathy (HP:0000114)1.82660050
112Abnormality of transition element cation homeostasis (HP:0011030)1.81052291
113Abnormality of iron homeostasis (HP:0011031)1.79678379
114Confusion (HP:0001289)1.79077220
115Abnormal enzyme/coenzyme activity (HP:0012379)1.78979770
116Hammertoe (HP:0001765)1.78656057
117Purpura (HP:0000979)1.78253706
118Bronchomalacia (HP:0002780)1.77699517
119Advanced eruption of teeth (HP:0006288)1.77006631
120Abnormality of glycolysis (HP:0004366)1.76173378
121Abnormality of pain sensation (HP:0010832)1.75255883
122Impaired pain sensation (HP:0007328)1.75255883
123Arterial tortuosity (HP:0005116)1.74924805
124Nephritis (HP:0000123)1.74810229
125Cerebral edema (HP:0002181)1.74168182
126Stroke (HP:0001297)1.74121542
127Reticulocytosis (HP:0001923)1.72606381
128Hyperglycemia (HP:0003074)1.72416977
129Hyperacusis (HP:0010780)1.71365521
130Neonatal short-limb short stature (HP:0008921)1.71295562
131Insomnia (HP:0100785)1.70228148
132Premature rupture of membranes (HP:0001788)1.70098304
133Cerebral aneurysm (HP:0004944)1.69697470
134Abnormal delivery (HP:0001787)1.67863535
135Achilles tendon contracture (HP:0001771)1.62881981
136Vascular tortuosity (HP:0004948)1.62133048
137Axonal loss (HP:0003447)1.61418093
138Action tremor (HP:0002345)1.61169052
139Mucopolysacchariduria (HP:0008155)1.60772339
140Urinary glycosaminoglycan excretion (HP:0003541)1.60772339
141Increased serum pyruvate (HP:0003542)1.58866800
142Abnormality of oral frenula (HP:0000190)1.57154097
143Wormian bones (HP:0002645)1.56740767
144Turricephaly (HP:0000262)1.56038243
145Polygenic inheritance (HP:0010982)1.55562337
146Dysmetric saccades (HP:0000641)1.52725034
147Hemangiomatosis (HP:0007461)1.52332693
148Heterotopia (HP:0002282)1.50433674
149Supranuclear gaze palsy (HP:0000605)1.49873838
150Abnormality of the acetabulum (HP:0003170)1.49807991
151Bifid scrotum (HP:0000048)1.49641429
152Relative macrocephaly (HP:0004482)1.49573470
153Abnormal foot bone ossification (HP:0010675)1.49207778
154Renal duplication (HP:0000075)1.48804152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.65128929
2SIK14.16811878
3TRIB33.99133721
4ERN13.82789886
5PKN23.62785831
6FGFR43.54659841
7ICK3.02798617
8PRPF4B2.35441953
9ERBB42.28896785
10LATS12.05575571
11PTK62.02358909
12SMG11.81185784
13NTRK11.81051357
14FLT31.80071572
15MAP2K41.77383228
16RIPK11.65492309
17CAMK1D1.65432117
18TAOK31.64701039
19NEK91.59363799
20TYRO31.57918772
21IRAK31.57571584
22MST1R1.52603567
23NTRK31.51027492
24MAPK111.43815386
25NEK11.41321380
26ARAF1.40835331
27INSRR1.40503997
28CDK61.37032542
29MAP3K101.30311077
30PIK3CG1.24075158
31FGFR21.20898365
32KSR21.20398736
33JAK21.17898387
34BMX1.16855635
35PBK1.12542781
36FRK1.10935766
37MAP3K91.10501685
38LRRK21.09639355
39MAP3K71.08972463
40ABL21.08675140
41TYK21.04320009
42NEK61.03715341
43SGK31.03476177
44GRK61.02090489
45LMTK21.00644274
46PRKAA20.99777787
47SCYL20.99618867
48ERBB20.97563381
49MAP2K30.96578294
50STK100.94342940
51FGFR30.90353507
52PTK20.90267710
53PDGFRA0.89660113
54PDGFRB0.89507694
55EPHB10.88330074
56DDR20.87556485
57MET0.87159342
58JAK10.86264560
59KDR0.86158683
60CAMK1G0.85640245
61NTRK20.84989765
62RET0.84407994
63TESK10.83536598
64AKT30.83394353
65DAPK20.79400155
66LATS20.79017091
67WNK10.78078993
68WNK30.77781605
69PAK40.77027657
70MTOR0.76159229
71CAMKK10.74899167
72GSK3A0.74100365
73MARK20.72219058
74PRKACG0.71070107
75CDK40.70957698
76MOS0.70508124
77PDPK10.69485259
78MAP3K110.68501577
79PAK20.68005664
80MAP3K30.67841828
81TBK10.67159991
82DYRK1B0.66769245
83FER0.65547291
84MAPK100.63834154
85PINK10.63664432
86EPHA20.63237134
87CSK0.62800136
88EIF2AK10.62463662
89SGK20.62336822
90MAP3K80.61780987
91FGFR10.61678220
92RPS6KB10.61045363
93STK38L0.60789418
94PRKCZ0.60538797
95PAK30.60526080
96MAPK40.60317181
97RAF10.59810747
98ROCK20.59729133
99PRKAA10.58820934
100MAP3K50.57982581
101PRKD30.56460403
102EPHA40.56363394
103CDK150.55944480
104PDK10.55348108
105STK380.53117380
106MAP3K20.52835516
107UHMK10.52280576
108MAP2K10.52027932
109MAPK120.50999218
110CDK180.50903386
111BRAF0.50130643
112TGFBR20.49577632
113CDK140.49324516
114EEF2K0.48582245
115MINK10.48355344
116SGK10.47584612
117CDK11A0.47301774
118EGFR0.45075039
119YES10.42913460
120CDK120.42464654
121PRKG20.41950268
122IGF1R0.41422121
123TIE10.41258792
124BRSK10.40186118
125MAP3K130.39774935
126SGK4940.39269197
127SGK2230.39269197
128CAMK2B0.38667829
129CDK50.38408086
130PRKCH0.38400303
131SRC0.36396031
132CAMK2D0.35661194
133ALK0.35408631
134PRKCQ0.33600249
135PIK3CA0.33434526
136TAOK20.33111808
137STK30.32465888
138MAP3K10.30877074
139PAK60.30289995
140CAMK2G0.30111822
141AKT20.29656132
142TTN0.28982124
143KSR10.27439012

Predicted pathways (KEGG)

RankGene SetZ-score
1* Nitrogen metabolism_Homo sapiens_hsa009104.34515370
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.16249631
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35594682
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31754134
5* Arginine biosynthesis_Homo sapiens_hsa002203.05501739
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82894083
7Fatty acid degradation_Homo sapiens_hsa000712.71351756
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66619499
9Tryptophan metabolism_Homo sapiens_hsa003802.61889575
10Complement and coagulation cascades_Homo sapiens_hsa046102.59910715
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54052608
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51338902
13Butanoate metabolism_Homo sapiens_hsa006502.22306009
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16946758
15Propanoate metabolism_Homo sapiens_hsa006402.05587445
16Peroxisome_Homo sapiens_hsa041462.03480050
17PPAR signaling pathway_Homo sapiens_hsa033202.01718329
18Fatty acid metabolism_Homo sapiens_hsa012122.00797760
19* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.88789469
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86579519
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79447848
22Bile secretion_Homo sapiens_hsa049761.72572247
23beta-Alanine metabolism_Homo sapiens_hsa004101.67697744
24Chemical carcinogenesis_Homo sapiens_hsa052041.65476842
25Other glycan degradation_Homo sapiens_hsa005111.65395690
26Staphylococcus aureus infection_Homo sapiens_hsa051501.65150391
27Histidine metabolism_Homo sapiens_hsa003401.64465722
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58792104
29Selenocompound metabolism_Homo sapiens_hsa004501.58546310
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.57069231
31Caffeine metabolism_Homo sapiens_hsa002321.56992170
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.53910245
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51295208
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50383373
35Biosynthesis of amino acids_Homo sapiens_hsa012301.40583975
36Retinol metabolism_Homo sapiens_hsa008301.37346486
37Pyruvate metabolism_Homo sapiens_hsa006201.35732700
38Phenylalanine metabolism_Homo sapiens_hsa003601.35484202
39Starch and sucrose metabolism_Homo sapiens_hsa005001.28833695
40* Carbon metabolism_Homo sapiens_hsa012001.28682251
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.27078633
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25464136
43* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24389038
44Sulfur metabolism_Homo sapiens_hsa009201.19551986
45Tyrosine metabolism_Homo sapiens_hsa003501.18218927
46Fat digestion and absorption_Homo sapiens_hsa049751.18182751
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.16222621
48ABC transporters_Homo sapiens_hsa020101.08165065
49Folate biosynthesis_Homo sapiens_hsa007901.07415866
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05841897
51Steroid biosynthesis_Homo sapiens_hsa001001.03183836
52Fatty acid elongation_Homo sapiens_hsa000621.00787517
53Arginine and proline metabolism_Homo sapiens_hsa003300.93980172
54Lysine degradation_Homo sapiens_hsa003100.93526624
55Fatty acid biosynthesis_Homo sapiens_hsa000610.92850458
56Vitamin digestion and absorption_Homo sapiens_hsa049770.91830827
57Long-term potentiation_Homo sapiens_hsa047200.90816966
58One carbon pool by folate_Homo sapiens_hsa006700.88220445
59Sulfur relay system_Homo sapiens_hsa041220.84278992
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.82085672
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80918144
62Vitamin B6 metabolism_Homo sapiens_hsa007500.77891292
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76628899
64Glycerolipid metabolism_Homo sapiens_hsa005610.74699464
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72556025
66Chronic myeloid leukemia_Homo sapiens_hsa052200.70703546
67Pentose phosphate pathway_Homo sapiens_hsa000300.68857281
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68140562
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68097255
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67410195
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65946341
72Glioma_Homo sapiens_hsa052140.64312406
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64242291
74Endometrial cancer_Homo sapiens_hsa052130.63989941
75Non-small cell lung cancer_Homo sapiens_hsa052230.63888023
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62777558
77Adherens junction_Homo sapiens_hsa045200.61589301
78Glutathione metabolism_Homo sapiens_hsa004800.60740272
79Estrogen signaling pathway_Homo sapiens_hsa049150.58599349
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53827436
81Sphingolipid metabolism_Homo sapiens_hsa006000.52576174
82Proteoglycans in cancer_Homo sapiens_hsa052050.50721585
83ErbB signaling pathway_Homo sapiens_hsa040120.50270388
84Thyroid cancer_Homo sapiens_hsa052160.49412094
85VEGF signaling pathway_Homo sapiens_hsa043700.49283664
86GnRH signaling pathway_Homo sapiens_hsa049120.49170603
87Inositol phosphate metabolism_Homo sapiens_hsa005620.47613186
88Focal adhesion_Homo sapiens_hsa045100.46563052
89ECM-receptor interaction_Homo sapiens_hsa045120.46236313
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45323828
91Pancreatic cancer_Homo sapiens_hsa052120.44139275
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.42775116
93Choline metabolism in cancer_Homo sapiens_hsa052310.37868156
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.36730108
95Insulin resistance_Homo sapiens_hsa049310.36570304
96Prion diseases_Homo sapiens_hsa050200.36503654
97mTOR signaling pathway_Homo sapiens_hsa041500.36191317
98Pertussis_Homo sapiens_hsa051330.35883815
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.35518578
100Vibrio cholerae infection_Homo sapiens_hsa051100.35094855
101Galactose metabolism_Homo sapiens_hsa000520.32819060
102* Metabolic pathways_Homo sapiens_hsa011000.32100780
103Fructose and mannose metabolism_Homo sapiens_hsa000510.29695906
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27333291
105Glucagon signaling pathway_Homo sapiens_hsa049220.21426195
106AMPK signaling pathway_Homo sapiens_hsa041520.12665389
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10735748
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.10139800
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.02834860
110Insulin signaling pathway_Homo sapiens_hsa049100.02510234
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00695227
112Renin-angiotensin system_Homo sapiens_hsa046140.00443425
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1914162
114Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1859085
115Mineral absorption_Homo sapiens_hsa04978-0.1785625
116Hepatitis C_Homo sapiens_hsa05160-0.1755242
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1736082
118African trypanosomiasis_Homo sapiens_hsa05143-0.1652668
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1642045
120Lysosome_Homo sapiens_hsa04142-0.1603797
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1558113
122Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1395468
123Amoebiasis_Homo sapiens_hsa05146-0.1261957
124Protein digestion and absorption_Homo sapiens_hsa04974-0.1241469
125Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0687137
126Bladder cancer_Homo sapiens_hsa05219-0.0540903
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0532454
128Linoleic acid metabolism_Homo sapiens_hsa00591-0.0467936
129Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0392140
130Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0270240
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0185690

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