ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell wall macromolecule metabolic process (GO:0044036)	7.09052072
2	positive regulation of chemokine secretion (GO:0090197)	4.64537437
3	pyrimidine nucleobase catabolic process (GO:0006208)	4.62944247
4	positive regulation of mitochondrial fission (GO:0090141)	4.50232582
5	ribonucleoprotein complex disassembly (GO:0032988)	4.49757676
6	glucosamine-containing compound catabolic process (GO:1901072)	4.48828742
7	nucleobase catabolic process (GO:0046113)	4.35220079
8	protein localization to cilium (GO:0061512)	4.14046506
9	peptidyl-histidine modification (GO:0018202)	4.12937745
10	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.02899337
11	DNA integration (GO:0015074)	3.94764410
12	regulation of chemokine secretion (GO:0090196)	3.82672287
13	organelle disassembly (GO:1903008)	3.80325569
14	DNA double-strand break processing (GO:0000729)	3.74469913
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.59939907
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.59939907
17	NADH dehydrogenase complex assembly (GO:0010257)	3.59939907
18	protein-cofactor linkage (GO:0018065)	3.53377858
19	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.47436546
20	intraciliary transport (GO:0042073)	3.46805391
21	cullin deneddylation (GO:0010388)	3.37332285
22	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.36391918
23	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.36391918
24	ADP metabolic process (GO:0046031)	3.36042368
25	metallo-sulfur cluster assembly (GO:0031163)	3.35378196
26	iron-sulfur cluster assembly (GO:0016226)	3.35378196
27	cellular ketone body metabolic process (GO:0046950)	3.32333217
28	pyrimidine dimer repair (GO:0006290)	3.31622475
29	ubiquinone metabolic process (GO:0006743)	3.31037992
30	positive regulation of granulocyte differentiation (GO:0030854)	3.25822935
31	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.22630410
32	amino acid salvage (GO:0043102)	3.18341207
33	L-methionine salvage (GO:0071267)	3.18341207
34	L-methionine biosynthetic process (GO:0071265)	3.18341207
35	muscle cell cellular homeostasis (GO:0046716)	3.13129936
36	regulation of mitochondrial fission (GO:0090140)	3.11222444
37	ubiquinone biosynthetic process (GO:0006744)	3.10925928
38	DNA deamination (GO:0045006)	3.10478397
39	base-excision repair, AP site formation (GO:0006285)	3.09405995
40	protein complex biogenesis (GO:0070271)	3.03373453
41	histone H2A acetylation (GO:0043968)	3.03047476
42	proteasome assembly (GO:0043248)	3.02634931
43	cilium or flagellum-dependent cell motility (GO:0001539)	2.99252455
44	protein deneddylation (GO:0000338)	2.94171459
45	pyrimidine nucleotide catabolic process (GO:0006244)	2.91121071
46	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.90716258
47	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.90557483
48	spermatid nucleus differentiation (GO:0007289)	2.90018477
49	positive regulation of receptor biosynthetic process (GO:0010870)	2.89519286
50	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.88677416
51	GPI anchor metabolic process (GO:0006505)	2.85899024
52	ketone body metabolic process (GO:1902224)	2.80868506
53	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	2.76671395
54	positive regulation of megakaryocyte differentiation (GO:0045654)	2.72153205
55	mannosylation (GO:0097502)	2.70148116
56	gamma-aminobutyric acid transport (GO:0015812)	2.69522230
57	behavioral response to ethanol (GO:0048149)	2.68466869
58	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66127792
59	C-terminal protein lipidation (GO:0006501)	2.62595950
60	neural tube formation (GO:0001841)	2.62282701
61	rhodopsin mediated signaling pathway (GO:0016056)	2.60709562
62	production of molecular mediator involved in inflammatory response (GO:0002532)	2.60587644
63	inositol phosphate catabolic process (GO:0071545)	2.59918241
64	snRNA processing (GO:0016180)	2.59856134
65	GPI anchor biosynthetic process (GO:0006506)	2.58311520
66	amino sugar catabolic process (GO:0046348)	2.56599775
67	negative regulation of cell cycle arrest (GO:0071157)	2.56044175
68	water-soluble vitamin biosynthetic process (GO:0042364)	2.55499286
69	membrane tubulation (GO:0097320)	2.54592003
70	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.53248279
71	protein insertion into membrane (GO:0051205)	2.52125731
72	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.50135497
73	negative regulation of telomere maintenance (GO:0032205)	2.47749290
74	head development (GO:0060322)	2.47434407
75	DNA damage response, detection of DNA damage (GO:0042769)	2.46331583
76	C-terminal protein amino acid modification (GO:0018410)	2.45287021
77	DNA demethylation (GO:0080111)	2.45277293
78	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.44127832
79	epithelial cilium movement (GO:0003351)	2.42889497
80	regulation of oxidative stress-induced neuron death (GO:1903203)	2.42237574
81	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.42124521
82	preassembly of GPI anchor in ER membrane (GO:0016254)	2.41087898
83	cholesterol biosynthetic process (GO:0006695)	2.39772816
84	positive regulation of protein homodimerization activity (GO:0090073)	2.39433679
85	quinone biosynthetic process (GO:1901663)	2.38996178
86	glycolipid biosynthetic process (GO:0009247)	2.38929866
87	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.38633548
88	oxidative phosphorylation (GO:0006119)	2.38183492
89	acrosome reaction (GO:0007340)	2.36082090
90	protein ADP-ribosylation (GO:0006471)	2.35887883
91	dicarboxylic acid catabolic process (GO:0043649)	2.35253805
92	coenzyme catabolic process (GO:0009109)	2.34784883
93	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.34441839
94	positive regulation of B cell differentiation (GO:0045579)	2.34371165
95	isoprenoid biosynthetic process (GO:0008299)	2.33782095
96	DNA dealkylation (GO:0035510)	2.32807809
97	axoneme assembly (GO:0035082)	2.32629326
98	positive regulation of release of cytochrome c from mitochondria (GO:0090200)	2.31979363
99	regulation of telomere maintenance (GO:0032204)	2.30743713
100	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.30324166

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	5.26714311
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.41481376
3	ZNF274_21170338_ChIP-Seq_K562_Hela	4.21993348
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.16686162
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.22326606
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.05450236
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.98661177
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.81600736
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.77747169
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.72133184
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.62820470
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.50473709
13	CIITA_25753668_ChIP-Seq_RAJI_Human	2.43511882
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.42260523
15	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.29830482
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.18139803
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.03245932
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.96426810
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95003768
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.93578653
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.92922206
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.84969340
23	GABP_19822575_ChIP-Seq_HepG2_Human	1.84799626
24	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.84552627
25	DCP1A_22483619_ChIP-Seq_HELA_Human	1.77005082
26	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.75574305
27	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.73635014
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72759752
29	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.72458099
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.69353257
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.63849788
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.59495675
33	EWS_26573619_Chip-Seq_HEK293_Human	1.54362840
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49379969
35	VDR_22108803_ChIP-Seq_LS180_Human	1.48963020
36	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.47339069
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.47025890
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.45569286
39	KDM5A_27292631_Chip-Seq_BREAST_Human	1.45010207
40	FUS_26573619_Chip-Seq_HEK293_Human	1.44941659
41	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.44849113
42	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.44538231
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.41112866
44	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.34971250
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.32554302
46	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.32315366
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30196518
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.29597318
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29164722
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.29164722
51	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.28606281
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.27978149
53	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.25596071
54	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.24444262
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23766574
56	GATA3_26560356_Chip-Seq_TH2_Human	1.21944631
57	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.19766699
58	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.19328318
59	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.19265920
60	NCOR_22424771_ChIP-Seq_293T_Human	1.18728143
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17545873
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17443754
63	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.12516714
64	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.08201106
65	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.07972980
66	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.06860406
67	MYC_19829295_ChIP-Seq_ESCs_Human	1.04610216
68	P300_19829295_ChIP-Seq_ESCs_Human	1.04345600
69	TAF15_26573619_Chip-Seq_HEK293_Human	0.98527134
70	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.98291239
71	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.98267172
72	XRN2_22483619_ChIP-Seq_HELA_Human	0.98201673
73	AR_20517297_ChIP-Seq_VCAP_Human	0.97341865
74	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.96303720
75	RNF2_27304074_Chip-Seq_NSC_Mouse	0.95919107
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95294029
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95153252
78	SPI1_23547873_ChIP-Seq_NB4_Human	0.91855659
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.89210993
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88292822
81	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.87111462
82	TTF2_22483619_ChIP-Seq_HELA_Human	0.85994701
83	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.85441228
84	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.85203863
85	GATA3_27048872_Chip-Seq_THYMUS_Human	0.84966516
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.84772044
87	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.84428954
88	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.84321044
89	TFEB_21752829_ChIP-Seq_HELA_Human	0.83002284
90	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.82151027
91	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.80469019
92	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.80339745
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.79933292
94	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.79606356
95	RAC3_21632823_ChIP-Seq_H3396_Human	0.79322873
96	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.79267408
97	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.77495914
98	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.77355917
99	ERA_21632823_ChIP-Seq_H3396_Human	0.77063392
100	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.76290078

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	3.35480625
2	MP0005645_abnormal_hypothalamus_physiol	2.84794950
3	MP0001529_abnormal_vocalization	2.50593231
4	MP0001764_abnormal_homeostasis	2.41796505
5	MP0002638_abnormal_pupillary_reflex	2.36822406
6	MP0001986_abnormal_taste_sensitivity	2.29189826
7	MP0006072_abnormal_retinal_apoptosis	2.27871956
8	MP0002837_dystrophic_cardiac_calcinosis	2.26500459
9	MP0005499_abnormal_olfactory_system	2.26017976
10	MP0005394_taste/olfaction_phenotype	2.26017976
11	MP0004147_increased_porphyrin_level	2.13926888
12	MP0009046_muscle_twitch	2.12463292
13	MP0005187_abnormal_penis_morphology	2.10679900
14	MP0001984_abnormal_olfaction	2.10557056
15	MP0006276_abnormal_autonomic_nervous	2.09908403
16	MP0005253_abnormal_eye_physiology	2.08109863
17	MP0005646_abnormal_pituitary_gland	1.99717281
18	MP0003221_abnormal_cardiomyocyte_apopto	1.99284010
19	MP0006036_abnormal_mitochondrial_physio	1.97616614
20	MP0003880_abnormal_central_pattern	1.97507135
21	MP0009697_abnormal_copulation	1.96482974
22	MP0002653_abnormal_ependyma_morphology	1.94800606
23	MP0001188_hyperpigmentation	1.90663772
24	MP0002139_abnormal_hepatobiliary_system	1.86072156
25	MP0008789_abnormal_olfactory_epithelium	1.81057472
26	MP0002102_abnormal_ear_morphology	1.75859704
27	MP0006035_abnormal_mitochondrial_morpho	1.74874585
28	MP0008058_abnormal_DNA_repair	1.69851638
29	MP0001502_abnormal_circadian_rhythm	1.66036051
30	MP0003656_abnormal_erythrocyte_physiolo	1.57119202
31	MP0003806_abnormal_nucleotide_metabolis	1.53932327
32	MP0005551_abnormal_eye_electrophysiolog	1.50755645
33	MP0003786_premature_aging	1.49326232
34	MP0005397_hematopoietic_system_phenotyp	1.48643772
35	MP0001545_abnormal_hematopoietic_system	1.48643772
36	MP0000465_gastrointestinal_hemorrhage	1.39140007
37	MP0002822_catalepsy	1.35569274
38	MP0002751_abnormal_autonomic_nervous	1.33628432
39	MP0002009_preneoplasia	1.32848689
40	MP0000749_muscle_degeneration	1.28502498
41	MP0001486_abnormal_startle_reflex	1.26472032
42	MP0003303_peritoneal_inflammation	1.20872009
43	MP0001905_abnormal_dopamine_level	1.17260664
44	MP0008877_abnormal_DNA_methylation	1.16985488
45	MP0008260_abnormal_autophagy	1.12690491
46	MP0003787_abnormal_imprinting	1.12519023
47	MP0008007_abnormal_cellular_replicative	1.11089284
48	MP0000372_irregular_coat_pigmentation	1.08579998
49	MP0002160_abnormal_reproductive_system	1.07682591
50	MP0003315_abnormal_perineum_morphology	1.07203677
51	MP0001968_abnormal_touch/_nociception	1.06034350
52	MP0004859_abnormal_synaptic_plasticity	1.02259245
53	MP0005084_abnormal_gallbladder_morpholo	1.02218996
54	MP0005167_abnormal_blood-brain_barrier	1.00208016
55	MP0003122_maternal_imprinting	0.99728580
56	MP0004133_heterotaxia	0.99512438
57	MP0002332_abnormal_exercise_endurance	0.98856226
58	MP0004811_abnormal_neuron_physiology	0.98794216
59	MP0001835_abnormal_antigen_presentation	0.96168684
60	MP0002557_abnormal_social/conspecific_i	0.95496090
61	MP0002272_abnormal_nervous_system	0.94589729
62	MP0002229_neurodegeneration	0.92596415
63	MP0002572_abnormal_emotion/affect_behav	0.92065397
64	MP0005266_abnormal_metabolism	0.91918001
65	MP0009785_altered_susceptibility_to	0.91457677
66	MP0003698_abnormal_male_reproductive	0.90749848
67	MP0001501_abnormal_sleep_pattern	0.90058761
68	MP0000647_abnormal_sebaceous_gland	0.87885995
69	MP0009745_abnormal_behavioral_response	0.85403623
70	MP0004924_abnormal_behavior	0.84326293
71	MP0005386_behavior/neurological_phenoty	0.84326293
72	MP0005535_abnormal_body_temperature	0.83743029
73	MP0000358_abnormal_cell_content/	0.83438654
74	MP0002752_abnormal_somatic_nervous	0.82571446
75	MP0005410_abnormal_fertilization	0.81470546
76	MP0003436_decreased_susceptibility_to	0.80743586
77	MP0002064_seizures	0.80382241
78	MP0004484_altered_response_of	0.79933481
79	MP0002184_abnormal_innervation	0.79211535
80	MP0004215_abnormal_myocardial_fiber	0.74596482
81	MP0004085_abnormal_heartbeat	0.74518578
82	MP0002132_abnormal_respiratory_system	0.74493151
83	MP0005391_vision/eye_phenotype	0.73744892
84	MP0003635_abnormal_synaptic_transmissio	0.72765975
85	MP0001929_abnormal_gametogenesis	0.72730849
86	MP0009764_decreased_sensitivity_to	0.72588481
87	MP0002063_abnormal_learning/memory/cond	0.69890392
88	MP0005058_abnormal_lysosome_morphology	0.69754369
89	MP0001270_distended_abdomen	0.69368001
90	MP0002882_abnormal_neuron_morphology	0.68642468
91	MP0001800_abnormal_humoral_immune	0.68631562
92	MP0005376_homeostasis/metabolism_phenot	0.68102626
93	MP0004142_abnormal_muscle_tone	0.67374625
94	MP0000631_abnormal_neuroendocrine_gland	0.65891904
95	MP0005334_abnormal_fat_pad	0.65122939
96	MP0002069_abnormal_eating/drinking_beha	0.64879653
97	MP0005085_abnormal_gallbladder_physiolo	0.64416652
98	MP0000751_myopathy	0.63958530
99	MP0001970_abnormal_pain_threshold	0.62251828
100	MP0002067_abnormal_sensory_capabilities	0.62009066

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	3.21241784
2	Retinal dysplasia (HP:0007973)	3.15238768
3	Pancreatic cysts (HP:0001737)	3.15102524
4	Tubulointerstitial nephritis (HP:0001970)	3.11132276
5	Medial flaring of the eyebrow (HP:0010747)	3.06624752
6	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.06361860
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.06361860
8	Hypothermia (HP:0002045)	3.00526897
9	Nephronophthisis (HP:0000090)	2.98515410
10	Lipid accumulation in hepatocytes (HP:0006561)	2.92055804
11	Progressive inability to walk (HP:0002505)	2.90418479
12	Congenital primary aphakia (HP:0007707)	2.90149452
13	Fibular aplasia (HP:0002990)	2.84760423
14	Methylmalonic acidemia (HP:0002912)	2.83847371
15	Inability to walk (HP:0002540)	2.81074054
16	3-Methylglutaconic aciduria (HP:0003535)	2.81034842
17	Gait imbalance (HP:0002141)	2.78943163
18	Hepatocellular necrosis (HP:0001404)	2.71417115
19	Attenuation of retinal blood vessels (HP:0007843)	2.67999027
20	Hepatic necrosis (HP:0002605)	2.64025357
21	Nephrogenic diabetes insipidus (HP:0009806)	2.61898436
22	Mitochondrial inheritance (HP:0001427)	2.60538304
23	Polyphagia (HP:0002591)	2.58494107
24	Abnormality of the hip-girdle musculature (HP:0001445)	2.54130461
25	Abnormality of the musculature of the pelvis (HP:0001469)	2.54130461
26	Rimmed vacuoles (HP:0003805)	2.53910112
27	Increased CSF lactate (HP:0002490)	2.51185036
28	Amblyopia (HP:0000646)	2.48927393
29	Abnormal mitochondria in muscle tissue (HP:0008316)	2.44973635
30	Increased muscle lipid content (HP:0009058)	2.44054534
31	Abnormality of the columella (HP:0009929)	2.42157228
32	Acute necrotizing encephalopathy (HP:0006965)	2.40864145
33	Renal cortical cysts (HP:0000803)	2.38024577
34	Granulocytopenia (HP:0001913)	2.34902600
35	Absent speech (HP:0001344)	2.33606608
36	Optic disc pallor (HP:0000543)	2.31427604
37	Methylmalonic aciduria (HP:0012120)	2.31396106
38	Abnormality of the renal medulla (HP:0100957)	2.30818536
39	Shoulder girdle muscle weakness (HP:0003547)	2.27255335
40	Chronic hepatic failure (HP:0100626)	2.25419138
41	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.24269710
42	Eosinophilia (HP:0001880)	2.22802097
43	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.22140826
44	Neonatal respiratory distress (HP:0002643)	2.21389755
45	Recurrent corneal erosions (HP:0000495)	2.20825551
46	Dicarboxylic aciduria (HP:0003215)	2.19218879
47	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.19218879
48	Emotional lability (HP:0000712)	2.19146258
49	Thyroid-stimulating hormone excess (HP:0002925)	2.18778542
50	Abnormal protein glycosylation (HP:0012346)	2.17039706
51	Abnormal glycosylation (HP:0012345)	2.17039706
52	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.17039706
53	Abnormal protein N-linked glycosylation (HP:0012347)	2.17039706
54	True hermaphroditism (HP:0010459)	2.15688902
55	Abnormal hair whorl (HP:0010721)	2.15415150
56	Failure to thrive in infancy (HP:0001531)	2.15272310
57	Acute encephalopathy (HP:0006846)	2.13699706
58	Pancreatic fibrosis (HP:0100732)	2.12795291
59	Poikiloderma (HP:0001029)	2.11315993
60	Hyperventilation (HP:0002883)	2.11015725
61	Pelvic girdle muscle weakness (HP:0003749)	2.10919793
62	Ragged-red muscle fibers (HP:0003200)	2.10907622
63	Long clavicles (HP:0000890)	2.09580822
64	Progressive macrocephaly (HP:0004481)	2.07624311
65	Aplasia/hypoplasia of the uterus (HP:0008684)	2.06619915
66	Lactic acidosis (HP:0003128)	2.06347572
67	Generalized aminoaciduria (HP:0002909)	2.05789159
68	Increased intramyocellular lipid droplets (HP:0012240)	2.05457959
69	Limb-girdle muscle atrophy (HP:0003797)	2.01620159
70	Poor coordination (HP:0002370)	2.01003031
71	Abnormality of macular pigmentation (HP:0008002)	1.96501955
72	Abnormality of eosinophils (HP:0001879)	1.95379939
73	Increased serum lactate (HP:0002151)	1.94020917
74	Abnormality of the renal cortex (HP:0011035)	1.91879938
75	Increased hepatocellular lipid droplets (HP:0006565)	1.91295555
76	Abnormality of the shoulder girdle musculature (HP:0001435)	1.89479864
77	Reticulocytosis (HP:0001923)	1.88886803
78	Sensorimotor neuropathy (HP:0007141)	1.88866733
79	Postaxial hand polydactyly (HP:0001162)	1.87636245
80	Type II lissencephaly (HP:0007260)	1.86653450
81	Specific learning disability (HP:0001328)	1.83050022
82	Abnormal rod and cone electroretinograms (HP:0008323)	1.82264934
83	Progressive cerebellar ataxia (HP:0002073)	1.82055682
84	Genital tract atresia (HP:0001827)	1.80789618
85	Abnormality of alanine metabolism (HP:0010916)	1.80615806
86	Hyperalaninemia (HP:0003348)	1.80615806
87	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.80615806
88	Type 2 muscle fiber atrophy (HP:0003554)	1.78300323
89	Dyskinesia (HP:0100660)	1.78157760
90	Atonic seizures (HP:0010819)	1.77848594
91	Vaginal atresia (HP:0000148)	1.77319908
92	Retinitis pigmentosa (HP:0000510)	1.76989790
93	Exercise-induced muscle cramps (HP:0003710)	1.76820209
94	Postaxial foot polydactyly (HP:0001830)	1.74939182
95	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.74839528
96	Agitation (HP:0000713)	1.74043087
97	Broad foot (HP:0001769)	1.72434136
98	Loss of speech (HP:0002371)	1.72021822
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.71654610
100	Exercise intolerance (HP:0003546)	1.70427913

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.74265671
2	MAP2K7	3.50855138
3	MAP3K4	2.79142199
4	PINK1	2.76956198
5	BCKDK	2.70089745
6	TRIM28	2.52784749
7	TESK2	2.52144602
8	SRPK1	2.48609159
9	CSNK1G3	2.40775747
10	EPHA3	2.25395285
11	BCR	2.20156668
12	MAP2K4	2.13327706
13	CSNK1A1L	2.12898778
14	CSNK1G2	2.04447462
15	MAP3K5	1.91974523
16	FRK	1.87435368
17	EIF2AK3	1.74194215
18	CSNK1G1	1.71128546
19	RPS6KA4	1.68083396
20	MAPK13	1.63927576
21	MAP3K6	1.62573695
22	PIK3CG	1.56069208
23	DYRK3	1.55042711
24	BMPR1B	1.50513683
25	GRK7	1.49764048
26	TLK1	1.49407150
27	SCYL2	1.37743615
28	MAP4K1	1.34096766
29	PIM2	1.33966838
30	WNK4	1.31527686
31	PDK2	1.29736282
32	DAPK2	1.29313769
33	DYRK2	1.26202434
34	ERBB3	1.25571319
35	ADRBK2	1.21299783
36	LATS1	1.16932001
37	STK38L	1.05552638
38	OBSCN	1.03490158
39	MARK1	1.01192116
40	WNK3	1.00949439
41	ZAK	1.00792815
42	SIK3	0.98825159
43	RPS6KA5	0.97615349
44	CCNB1	0.95441467
45	CAMKK2	0.94021547
46	CLK1	0.93538690
47	TAOK3	0.86914279
48	ADRBK1	0.86837169
49	GRK1	0.82939192
50	MATK	0.76678087
51	FLT3	0.72598283
52	MARK3	0.69596066
53	MAP2K3	0.69441185
54	KIT	0.68050789
55	LIMK1	0.67593132
56	SYK	0.66421025
57	TEC	0.66348362
58	MAP3K14	0.66082998
59	PRKCQ	0.65727138
60	BRD4	0.63463815
61	BTK	0.62733436
62	EPHA4	0.56798250
63	TNK2	0.56665137
64	MAP3K12	0.55691612
65	VRK1	0.54408033
66	AKT3	0.54077969
67	CDK14	0.53107728
68	DYRK1A	0.52098776
69	NUAK1	0.51113161
70	CAMK4	0.50513503
71	MAP2K6	0.50445275
72	MINK1	0.50415178
73	CSF1R	0.49312071
74	DAPK1	0.48071809
75	IRAK4	0.46595055
76	STK39	0.44284403
77	TXK	0.43484339
78	CSNK1A1	0.42842584
79	CHUK	0.41676344
80	CDK8	0.40688228
81	EGFR	0.39253645
82	IKBKB	0.38189706
83	LCK	0.38086167
84	ATR	0.37719759
85	PAK3	0.37369638
86	CDK3	0.37253083
87	PRKD3	0.36609644
88	BLK	0.35828961
89	UHMK1	0.35446104
90	PRKCE	0.34097285
91	SGK2	0.33659736
92	FER	0.33497118
93	IKBKE	0.33317650
94	FGR	0.31569334
95	ABL1	0.29753324
96	TBK1	0.27715661
97	HCK	0.26999677
98	DYRK1B	0.26698100
99	PIM1	0.26307401
100	TGFBR1	0.26120102

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.97192720
2	Regulation of autophagy_Homo sapiens_hsa04140	2.85097959
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.73254939
4	Circadian rhythm_Homo sapiens_hsa04710	2.47447291
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.41620523
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.33175657
7	Butanoate metabolism_Homo sapiens_hsa00650	2.25132424
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.21899521
9	Protein export_Homo sapiens_hsa03060	2.17701132
10	Asthma_Homo sapiens_hsa05310	2.11448670
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.03496929
12	Parkinsons disease_Homo sapiens_hsa05012	2.00407039
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.78387223
14	RNA polymerase_Homo sapiens_hsa03020	1.68067107
15	Propanoate metabolism_Homo sapiens_hsa00640	1.67055088
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.64524618
17	GABAergic synapse_Homo sapiens_hsa04727	1.61308662
18	Spliceosome_Homo sapiens_hsa03040	1.56704767
19	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.55114746
20	Olfactory transduction_Homo sapiens_hsa04740	1.47710194
21	Basal transcription factors_Homo sapiens_hsa03022	1.47387705
22	Allograft rejection_Homo sapiens_hsa05330	1.46917691
23	Nicotine addiction_Homo sapiens_hsa05033	1.46370451
24	Proteasome_Homo sapiens_hsa03050	1.44740359
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.44169813
26	RNA degradation_Homo sapiens_hsa03018	1.41153406
27	Base excision repair_Homo sapiens_hsa03410	1.40319013
28	Peroxisome_Homo sapiens_hsa04146	1.35738417
29	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.34635945
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32394726
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.31989847
32	Fatty acid elongation_Homo sapiens_hsa00062	1.31061255
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30710519
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.29159506
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.27578962
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.26673828
37	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.25280720
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.24314589
39	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.24298521
40	Huntingtons disease_Homo sapiens_hsa05016	1.20771659
41	Purine metabolism_Homo sapiens_hsa00230	1.15345990
42	Shigellosis_Homo sapiens_hsa05131	1.13563391
43	Graft-versus-host disease_Homo sapiens_hsa05332	1.11578442
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09239698
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08779994
46	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.08671330
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.08182401
48	Rheumatoid arthritis_Homo sapiens_hsa05323	1.04658416
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.99444043
50	Fatty acid metabolism_Homo sapiens_hsa01212	0.99292771
51	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.93685614
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92925965
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.91196355
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.85405610
55	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.81921843
56	mRNA surveillance pathway_Homo sapiens_hsa03015	0.81437881
57	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80365181
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.80230388
59	Phagosome_Homo sapiens_hsa04145	0.77078414
60	Taste transduction_Homo sapiens_hsa04742	0.75565921
61	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.74851346
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.74191231
63	Alzheimers disease_Homo sapiens_hsa05010	0.73786479
64	Circadian entrainment_Homo sapiens_hsa04713	0.73177431
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.72710646
66	RNA transport_Homo sapiens_hsa03013	0.69912290
67	Viral myocarditis_Homo sapiens_hsa05416	0.69632438
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.68720099
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64228942
70	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.62617454
71	Legionellosis_Homo sapiens_hsa05134	0.62608055
72	Metabolic pathways_Homo sapiens_hsa01100	0.60413585
73	Carbon metabolism_Homo sapiens_hsa01200	0.60270547
74	Herpes simplex infection_Homo sapiens_hsa05168	0.60184440
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.59545843
76	Morphine addiction_Homo sapiens_hsa05032	0.57796009
77	Alcoholism_Homo sapiens_hsa05034	0.56750595
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56011302
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54690041
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.54232817
81	Homologous recombination_Homo sapiens_hsa03440	0.53620882
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.53095640
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.52745115
84	Pentose phosphate pathway_Homo sapiens_hsa00030	0.50696671
85	Tuberculosis_Homo sapiens_hsa05152	0.50251309
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.48172051
87	Oocyte meiosis_Homo sapiens_hsa04114	0.48100201
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43388169
89	Arginine biosynthesis_Homo sapiens_hsa00220	0.42448756
90	Cocaine addiction_Homo sapiens_hsa05030	0.40530643
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.38495027
92	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.38038451
93	Lysosome_Homo sapiens_hsa04142	0.37135392
94	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.35778455
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35479031
96	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.33039984
97	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.32426587
98	Mismatch repair_Homo sapiens_hsa03430	0.32101812
99	Cardiac muscle contraction_Homo sapiens_hsa04260	0.31587843
100	Caffeine metabolism_Homo sapiens_hsa00232	0.29727201

GLUD1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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