GLUD1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of growth hormone secretion (GO:0060124)7.38670026
2growth hormone secretion (GO:0030252)6.41129867
3behavioral response to nicotine (GO:0035095)5.90114961
4positive regulation of oligodendrocyte differentiation (GO:0048714)5.35977317
5regulation of growth hormone secretion (GO:0060123)5.33623750
6cell wall macromolecule metabolic process (GO:0044036)4.53227825
7thalamus development (GO:0021794)4.43630899
8epithelial cilium movement (GO:0003351)4.41675429
9positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.22200897
10positive regulation of circadian rhythm (GO:0042753)4.21347698
11chaperone-mediated protein transport (GO:0072321)4.04174281
12regulation of circadian sleep/wake cycle (GO:0042749)3.92627937
13regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.92627937
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85213656
15maturation of SSU-rRNA (GO:0030490)3.73094261
16substrate-independent telencephalic tangential migration (GO:0021826)3.72460635
17substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.72460635
18response to food (GO:0032094)3.67848607
19regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.67366814
20pyrimidine nucleobase catabolic process (GO:0006208)3.61543907
21centriole replication (GO:0007099)3.44162470
22cilium movement (GO:0003341)3.32620075
23inner mitochondrial membrane organization (GO:0007007)3.31484368
24glycerophospholipid catabolic process (GO:0046475)3.27268663
25L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.26232326
26dentate gyrus development (GO:0021542)3.25835889
27intraciliary transport (GO:0042073)3.23722434
28forebrain morphogenesis (GO:0048853)3.22359953
29circadian sleep/wake cycle process (GO:0022410)3.18858431
30water-soluble vitamin biosynthetic process (GO:0042364)3.17940839
31negative regulation of telomere maintenance (GO:0032205)3.17763704
32positive regulation of catecholamine secretion (GO:0033605)3.16688782
33parturition (GO:0007567)3.14500045
34nonmotile primary cilium assembly (GO:0035058)3.13284802
35aspartate family amino acid catabolic process (GO:0009068)3.11816806
36regulation of cilium movement (GO:0003352)3.07876431
37coenzyme catabolic process (GO:0009109)3.07467243
38DNA double-strand break processing (GO:0000729)3.06498279
39DNA deamination (GO:0045006)3.02667825
40axonal fasciculation (GO:0007413)2.95456192
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94668504
42regulation of oligodendrocyte differentiation (GO:0048713)2.94059443
43nucleobase catabolic process (GO:0046113)2.93394614
44L-phenylalanine catabolic process (GO:0006559)2.89255517
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.89255517
46neuron fate determination (GO:0048664)2.88485825
47centriole assembly (GO:0098534)2.84845157
48cellular response to oxygen radical (GO:0071450)2.84785194
49removal of superoxide radicals (GO:0019430)2.84785194
50cellular response to superoxide (GO:0071451)2.84785194
51ganglion development (GO:0061548)2.78073562
52ribosomal small subunit assembly (GO:0000028)2.75544851
53detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.75327879
54peptidyl-histidine modification (GO:0018202)2.74758880
55aggressive behavior (GO:0002118)2.74573794
56type B pancreatic cell development (GO:0003323)2.73864250
57isoprenoid biosynthetic process (GO:0008299)2.71464309
58ubiquinone biosynthetic process (GO:0006744)2.70534934
59amino acid salvage (GO:0043102)2.70221060
60L-methionine salvage (GO:0071267)2.70221060
61L-methionine biosynthetic process (GO:0071265)2.70221060
62uterus development (GO:0060065)2.69689542
63establishment of protein localization to mitochondrial membrane (GO:0090151)2.69542936
64cilium morphogenesis (GO:0060271)2.67806259
65serine family amino acid catabolic process (GO:0009071)2.67637021
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66821861
67ribonucleoprotein complex disassembly (GO:0032988)2.65290086
68regulation of autophagic vacuole assembly (GO:2000785)2.64085135
69circadian behavior (GO:0048512)2.60736631
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59145812
71protein neddylation (GO:0045116)2.58032408
72phenylpropanoid metabolic process (GO:0009698)2.57266861
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.57248438
74ubiquinone metabolic process (GO:0006743)2.57101034
75protein localization to cilium (GO:0061512)2.56975030
76axonemal dynein complex assembly (GO:0070286)2.55631230
77glucosamine-containing compound catabolic process (GO:1901072)2.54590542
78regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.54406485
79cellular ketone body metabolic process (GO:0046950)2.53605853
80forebrain neuron differentiation (GO:0021879)2.52423767
81synaptic transmission, cholinergic (GO:0007271)2.49997804
82neuron fate commitment (GO:0048663)2.49811945
83aromatic amino acid family catabolic process (GO:0009074)2.49118245
84platelet dense granule organization (GO:0060155)2.46657357
85organelle disassembly (GO:1903008)2.45622690
86photoreceptor cell maintenance (GO:0045494)2.45454148
87dicarboxylic acid catabolic process (GO:0043649)2.45364778
88tyrosine metabolic process (GO:0006570)2.45002419
89drinking behavior (GO:0042756)2.44826264
90cell proliferation in forebrain (GO:0021846)2.44685276
91cAMP-mediated signaling (GO:0019933)2.43484624
92ATP synthesis coupled proton transport (GO:0015986)2.42007644
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.42007644
94rhythmic behavior (GO:0007622)2.41964422
95regulation of rhodopsin mediated signaling pathway (GO:0022400)2.41692407
96regulation of dopamine secretion (GO:0014059)2.41379732
97paraxial mesoderm development (GO:0048339)2.39889897
98negative regulation of transcription regulatory region DNA binding (GO:2000678)2.39672304
99kidney morphogenesis (GO:0060993)2.39603995
100negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38369525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.07018041
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.01270098
3ZNF274_21170338_ChIP-Seq_K562_Hela3.73299759
4IGF1R_20145208_ChIP-Seq_DFB_Human3.57662336
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25211402
6GBX2_23144817_ChIP-Seq_PC3_Human3.10499264
7EZH2_22144423_ChIP-Seq_EOC_Human3.02649987
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63720934
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49436962
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.46012156
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40146845
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25639110
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00625395
14ER_23166858_ChIP-Seq_MCF-7_Human1.99733006
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97341211
16VDR_22108803_ChIP-Seq_LS180_Human1.96424216
17P300_19829295_ChIP-Seq_ESCs_Human1.87806155
18FUS_26573619_Chip-Seq_HEK293_Human1.83594381
19AR_21572438_ChIP-Seq_LNCaP_Human1.80140603
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79450719
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79217866
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.75889715
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66772914
24EWS_26573619_Chip-Seq_HEK293_Human1.66698905
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59881991
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59881991
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.56272486
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55534593
29CBP_20019798_ChIP-Seq_JUKART_Human1.55534593
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.54437684
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52413211
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.51889624
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50905370
34KLF5_20875108_ChIP-Seq_MESCs_Mouse1.47930058
35IRF1_19129219_ChIP-ChIP_H3396_Human1.45198287
36NCOR_22424771_ChIP-Seq_293T_Human1.42434477
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37813410
38RNF2_27304074_Chip-Seq_NSC_Mouse1.33544293
39HOXB7_26014856_ChIP-Seq_BT474_Human1.32071748
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31959105
41NANOG_20526341_ChIP-Seq_ESCs_Human1.31034568
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30686525
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.30577758
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28864952
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27701477
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27130491
47BCAT_22108803_ChIP-Seq_LS180_Human1.26347071
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.26138536
49MYC_18940864_ChIP-ChIP_HL60_Human1.25931954
50ELK1_19687146_ChIP-ChIP_HELA_Human1.25328966
51SOX2_19829295_ChIP-Seq_ESCs_Human1.24190732
52NANOG_19829295_ChIP-Seq_ESCs_Human1.24190732
53CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23405657
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.22608016
55TP53_22573176_ChIP-Seq_HFKS_Human1.22530685
56SMAD4_21799915_ChIP-Seq_A2780_Human1.22358475
57VDR_23849224_ChIP-Seq_CD4+_Human1.20896309
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.19833185
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19357586
60REST_21632747_ChIP-Seq_MESCs_Mouse1.18631601
61RUNX2_22187159_ChIP-Seq_PCA_Human1.16137552
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16048770
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15888585
64STAT3_23295773_ChIP-Seq_U87_Human1.14507985
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.14300437
66TCF4_22108803_ChIP-Seq_LS180_Human1.13100749
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12714615
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11623528
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.11004387
70TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10482367
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09006759
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.08799833
73TCF4_23295773_ChIP-Seq_U87_Human1.07631136
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06806337
75FOXP3_21729870_ChIP-Seq_TREG_Human1.06548922
76AR_25329375_ChIP-Seq_VCAP_Human1.05290101
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03097136
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01313548
79CBP_21632823_ChIP-Seq_H3396_Human0.99225771
80MYC_19829295_ChIP-Seq_ESCs_Human0.97755909
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95482550
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95000459
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94893753
84FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94460758
85FOXA1_25329375_ChIP-Seq_VCAP_Human0.94460758
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.94379537
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94255018
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93517125
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93226987
90TP63_19390658_ChIP-ChIP_HaCaT_Human0.93206798
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91910556
92OCT4_20526341_ChIP-Seq_ESCs_Human0.91844830
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90642460
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.89134969
95SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88528256
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.88142717
97ERA_21632823_ChIP-Seq_H3396_Human0.87477394
98RXR_22108803_ChIP-Seq_LS180_Human0.86923004
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85190066
100WDR5_24793694_ChIP-Seq_LNCAP_Human0.84922822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.68374749
2MP0003136_yellow_coat_color3.64846134
3MP0003787_abnormal_imprinting3.49072919
4MP0001529_abnormal_vocalization2.92526006
5MP0003122_maternal_imprinting2.83576477
6MP0008789_abnormal_olfactory_epithelium2.69910848
7MP0002160_abnormal_reproductive_system2.63511673
8MP0002102_abnormal_ear_morphology2.62639683
9MP0005499_abnormal_olfactory_system2.45646360
10MP0005394_taste/olfaction_phenotype2.45646360
11MP0001502_abnormal_circadian_rhythm2.42810414
12MP0002653_abnormal_ependyma_morphology2.40858215
13MP0003123_paternal_imprinting2.34145710
14MP0006276_abnormal_autonomic_nervous2.15723145
15MP0002163_abnormal_gland_morphology2.15102469
16MP0004142_abnormal_muscle_tone2.05857508
17MP0006292_abnormal_olfactory_placode2.02615911
18MP0006072_abnormal_retinal_apoptosis1.99589025
19MP0001984_abnormal_olfaction1.88934545
20MP0001905_abnormal_dopamine_level1.81462177
21MP0003121_genomic_imprinting1.79958373
22MP0003315_abnormal_perineum_morphology1.75925242
23MP0003880_abnormal_central_pattern1.75084810
24MP0005551_abnormal_eye_electrophysiolog1.73311744
25MP0000778_abnormal_nervous_system1.68981539
26MP0002638_abnormal_pupillary_reflex1.63408895
27MP0000749_muscle_degeneration1.62843545
28MP0005379_endocrine/exocrine_gland_phen1.60724188
29MP0006036_abnormal_mitochondrial_physio1.59062625
30MP0006035_abnormal_mitochondrial_morpho1.57499858
31MP0005646_abnormal_pituitary_gland1.53222733
32MP0005253_abnormal_eye_physiology1.51736728
33MP0004147_increased_porphyrin_level1.50127828
34MP0001485_abnormal_pinna_reflex1.48186834
35MP0001968_abnormal_touch/_nociception1.46164590
36MP0005389_reproductive_system_phenotype1.39052503
37MP0009379_abnormal_foot_pigmentation1.31820301
38MP0002272_abnormal_nervous_system1.31772484
39MP0002233_abnormal_nose_morphology1.29006033
40MP0001486_abnormal_startle_reflex1.28169268
41MP0001501_abnormal_sleep_pattern1.25546601
42MP0005171_absent_coat_pigmentation1.24795458
43MP0008877_abnormal_DNA_methylation1.22736529
44MP0005377_hearing/vestibular/ear_phenot1.21760585
45MP0003878_abnormal_ear_physiology1.21760585
46MP0009745_abnormal_behavioral_response1.21170332
47MP0004885_abnormal_endolymph1.21064615
48MP0008995_early_reproductive_senescence1.18779766
49MP0003646_muscle_fatigue1.18748371
50MP0002090_abnormal_vision1.18398374
51MP0002557_abnormal_social/conspecific_i1.18238482
52MP0001764_abnormal_homeostasis1.16875862
53MP0009046_muscle_twitch1.16498925
54MP0001293_anophthalmia1.14910656
55MP0002095_abnormal_skin_pigmentation1.14441453
56MP0000230_abnormal_systemic_arterial1.11707059
57MP0002572_abnormal_emotion/affect_behav1.11255173
58MP0002736_abnormal_nociception_after1.11036568
59MP0005410_abnormal_fertilization1.05355672
60MP0000631_abnormal_neuroendocrine_gland1.05087107
61MP0005167_abnormal_blood-brain_barrier1.04902300
62MP0002938_white_spotting1.03958717
63MP0000427_abnormal_hair_cycle1.02750211
64MP0002752_abnormal_somatic_nervous1.02687311
65MP0003195_calcinosis1.01210713
66MP0003186_abnormal_redox_activity0.99598295
67MP0002067_abnormal_sensory_capabilities0.98763659
68MP0002132_abnormal_respiratory_system0.96475879
69MP0004742_abnormal_vestibular_system0.95287556
70MP0002751_abnormal_autonomic_nervous0.95035352
71MP0009697_abnormal_copulation0.94441210
72MP0003879_abnormal_hair_cell0.91849622
73MP0000026_abnormal_inner_ear0.88856149
74MP0005195_abnormal_posterior_eye0.88463964
75MP0004133_heterotaxia0.88295719
76MP0000049_abnormal_middle_ear0.87535775
77MP0008872_abnormal_physiological_respon0.84161207
78MP0002063_abnormal_learning/memory/cond0.84153240
79MP0003698_abnormal_male_reproductive0.83526801
80MP0002876_abnormal_thyroid_physiology0.83176123
81MP0005391_vision/eye_phenotype0.82861893
82MP0003890_abnormal_embryonic-extraembry0.81356115
83MP0001929_abnormal_gametogenesis0.81334020
84MP0002064_seizures0.79354422
85MP0003635_abnormal_synaptic_transmissio0.78254680
86MP0002069_abnormal_eating/drinking_beha0.76878200
87MP0002127_abnormal_cardiovascular_syste0.76293493
88MP0001188_hyperpigmentation0.76252502
89MP0001970_abnormal_pain_threshold0.75311986
90MP0005386_behavior/neurological_phenoty0.74647574
91MP0004924_abnormal_behavior0.74647574
92MP0001440_abnormal_grooming_behavior0.74448801
93MP0010030_abnormal_orbit_morphology0.74010528
94MP0001963_abnormal_hearing_physiology0.73763914
95MP0005645_abnormal_hypothalamus_physiol0.72503322
96MP0001986_abnormal_taste_sensitivity0.71577988
97MP0005085_abnormal_gallbladder_physiolo0.71554890
98MP0000653_abnormal_sex_gland0.71248258
99MP0003718_maternal_effect0.69209930
100MP0004085_abnormal_heartbeat0.69161396

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.55793083
2Neoplasm of the adrenal cortex (HP:0100641)4.19296869
3Abnormality of DNA repair (HP:0003254)4.04012217
4Pancreatic cysts (HP:0001737)3.42600104
5Hypoglycemic seizures (HP:0002173)3.41393080
6Reticulocytopenia (HP:0001896)3.05541149
7Pancreatic fibrosis (HP:0100732)3.04450515
8Medial flaring of the eyebrow (HP:0010747)3.00764120
9Metaphyseal dysplasia (HP:0100255)2.96913665
10Abnormality of the labia minora (HP:0012880)2.95913386
11Enlarged kidneys (HP:0000105)2.94866728
12Pendular nystagmus (HP:0012043)2.92876831
13Cerebellar dysplasia (HP:0007033)2.89307113
14True hermaphroditism (HP:0010459)2.88050497
15Duplicated collecting system (HP:0000081)2.84080566
16Congenital primary aphakia (HP:0007707)2.79291039
17Chronic hepatic failure (HP:0100626)2.78159412
18Gait imbalance (HP:0002141)2.77838517
19Abnormal pancreas size (HP:0012094)2.77685896
20Abnormality of the renal collecting system (HP:0004742)2.75733818
21Nephronophthisis (HP:0000090)2.75514097
22Nephrogenic diabetes insipidus (HP:0009806)2.75068632
23Colon cancer (HP:0003003)2.74101684
24Optic nerve hypoplasia (HP:0000609)2.70698980
25Absent thumb (HP:0009777)2.61643030
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.60489600
27Neoplasm of the adrenal gland (HP:0100631)2.57807313
28Type II lissencephaly (HP:0007260)2.57795713
293-Methylglutaconic aciduria (HP:0003535)2.55180522
30Hyperglycinemia (HP:0002154)2.53153978
31Acute encephalopathy (HP:0006846)2.52069451
32Acute necrotizing encephalopathy (HP:0006965)2.46874968
33Growth hormone deficiency (HP:0000824)2.45779557
34Abnormality of the renal medulla (HP:0100957)2.45280795
35Genital tract atresia (HP:0001827)2.44289051
36Vaginal atresia (HP:0000148)2.43934370
37Poor coordination (HP:0002370)2.43458938
38Abnormal number of erythroid precursors (HP:0012131)2.39824077
39Septo-optic dysplasia (HP:0100842)2.35919907
40Abnormality of cells of the erythroid lineage (HP:0012130)2.35138996
41Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32677025
42Focal motor seizures (HP:0011153)2.30340215
43Chorioretinal atrophy (HP:0000533)2.28056011
44Anophthalmia (HP:0000528)2.27867861
45Progressive macrocephaly (HP:0004481)2.22210538
46Abolished electroretinogram (ERG) (HP:0000550)2.21301523
47Diastasis recti (HP:0001540)2.20429412
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17449511
49Inability to walk (HP:0002540)2.16365993
50Abnormality of the ileum (HP:0001549)2.15558560
51Mitochondrial inheritance (HP:0001427)2.15465143
52High anterior hairline (HP:0009890)2.15093860
53Meckel diverticulum (HP:0002245)2.14432353
54Hepatocellular necrosis (HP:0001404)2.14250489
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13798633
56Microvesicular hepatic steatosis (HP:0001414)2.11425005
57Attenuation of retinal blood vessels (HP:0007843)2.10301314
58Abnormal respiratory motile cilium morphology (HP:0005938)2.06714278
59Abnormal respiratory epithelium morphology (HP:0012253)2.06714278
60Abnormal ciliary motility (HP:0012262)2.06304098
61Abnormal mitochondria in muscle tissue (HP:0008316)2.05436865
62Hepatic necrosis (HP:0002605)2.02685001
63Molar tooth sign on MRI (HP:0002419)2.01171175
64Abnormality of midbrain morphology (HP:0002418)2.01171175
65Adrenal hypoplasia (HP:0000835)2.00952921
66Male pseudohermaphroditism (HP:0000037)1.98972677
67Abnormal respiratory motile cilium physiology (HP:0012261)1.98387900
68Symptomatic seizures (HP:0011145)1.97652817
69Increased CSF lactate (HP:0002490)1.96628352
70Abnormal rod and cone electroretinograms (HP:0008323)1.96435848
71Abnormality of the renal cortex (HP:0011035)1.95693978
72Cystic liver disease (HP:0006706)1.95688490
73Poikiloderma (HP:0001029)1.95572434
74Hyperglycinuria (HP:0003108)1.90976293
75Chromsome breakage (HP:0040012)1.89261074
76Optic disc pallor (HP:0000543)1.86633598
77Retinal dysplasia (HP:0007973)1.86497758
78Polyphagia (HP:0002591)1.83817264
79Sensory axonal neuropathy (HP:0003390)1.82122017
80Ectopic kidney (HP:0000086)1.81205940
81Hyperinsulinemic hypoglycemia (HP:0000825)1.79098141
82Horseshoe kidney (HP:0000085)1.78991794
83Retinal atrophy (HP:0001105)1.78848966
84Anencephaly (HP:0002323)1.76751662
85Hypoglycemic coma (HP:0001325)1.75539954
86Postaxial hand polydactyly (HP:0001162)1.74907250
87Specific learning disability (HP:0001328)1.74804931
88Keratoconus (HP:0000563)1.74511863
89Increased corneal curvature (HP:0100692)1.74511863
90Cerebral edema (HP:0002181)1.73556602
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71134507
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.70324004
93Absent/shortened dynein arms (HP:0200106)1.70324004
94Broad foot (HP:0001769)1.69266831
95Rimmed vacuoles (HP:0003805)1.68837145
96Abnormality of the parathyroid morphology (HP:0011766)1.67683770
97Sclerocornea (HP:0000647)1.66109786
98Decreased central vision (HP:0007663)1.65249082
99Lipid accumulation in hepatocytes (HP:0006561)1.64959991
100Thyroid-stimulating hormone excess (HP:0002925)1.64683354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.09358164
2LATS13.16988048
3ZAK3.13880524
4FRK3.05964228
5MAP2K72.89690304
6STK38L2.58723913
7EPHA42.20946098
8MAP4K22.17496001
9BCKDK2.09107934
10BMPR1B2.04847452
11TLK12.02261141
12CAMKK21.81805902
13MST41.80365582
14STK161.79636791
15WNK41.74693497
16GRK11.72317512
17CDK191.68318172
18DYRK21.67346922
19MARK31.59802802
20DYRK31.57436615
21BRSK21.54736961
22EIF2AK31.53899651
23CSNK1A1L1.50791702
24ADRBK21.45490356
25NEK21.45101661
26OBSCN1.45019784
27WNK31.42213098
28TIE11.41860971
29CSNK1G31.32556117
30MAP3K41.31746360
31FGFR21.25567702
32CSNK1G21.25066687
33LATS21.21156400
34MAPKAPK31.18178035
35CSNK1G11.17960389
36NTRK31.14198282
37BCR1.14185385
38ACVR1B1.11402313
39PLK21.10323571
40TRIM280.99798825
41WEE10.99370318
42TAOK30.99108576
43GRK70.96497243
44NLK0.94798094
45ARAF0.94156484
46MAPK130.91982468
47RPS6KA50.90583872
48PIK3CA0.88779448
49PLK30.88565519
50MOS0.88276076
51PRKD30.85529448
52VRK10.85225510
53TGFBR10.82715530
54ADRBK10.80583089
55NTRK20.80308621
56LIMK10.78922811
57MKNK10.74966352
58PRKCQ0.71192818
59MAP2K40.71189497
60MAP3K90.66982490
61STK110.66518060
62PHKG20.64087895
63PHKG10.64087895
64NME10.62612453
65RPS6KA40.62481053
66EPHB20.62276949
67VRK20.61417393
68STK30.60228201
69CASK0.59291860
70MAPK150.58362015
71PRKCG0.58229624
72SRPK10.55743076
73PLK10.53660357
74MINK10.52246317
75SGK4940.52164216
76SGK2230.52164216
77TNIK0.51646440
78CAMKK10.51281431
79CAMK10.48102552
80OXSR10.47640161
81MAP3K50.46592446
82PAK30.46333981
83MYLK0.46107508
84MAPKAPK50.45612041
85CSNK1A10.45351108
86CDK30.45341938
87PBK0.41585833
88RPS6KB10.37471789
89BTK0.37178930
90MARK10.36542027
91ERBB30.36167971
92ATR0.35373949
93PRKCE0.31545662
94PRKACA0.31286302
95CDK50.30970402
96CDK140.30543603
97CSNK1D0.30337193
98DAPK30.30098123
99NUAK10.28938380
100ATM0.27989451

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.35817396
2Nitrogen metabolism_Homo sapiens_hsa009103.11920810
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.68807607
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67178889
5Oxidative phosphorylation_Homo sapiens_hsa001902.46014047
6Ribosome_Homo sapiens_hsa030102.41885313
7Butanoate metabolism_Homo sapiens_hsa006502.40894492
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30351481
9Parkinsons disease_Homo sapiens_hsa050122.27526921
10Olfactory transduction_Homo sapiens_hsa047402.18155606
11Propanoate metabolism_Homo sapiens_hsa006402.12640443
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00889038
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99067140
14Linoleic acid metabolism_Homo sapiens_hsa005911.97437328
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73536354
16Fanconi anemia pathway_Homo sapiens_hsa034601.71228123
17Peroxisome_Homo sapiens_hsa041461.69729766
18RNA polymerase_Homo sapiens_hsa030201.57367495
19Nicotine addiction_Homo sapiens_hsa050331.54358439
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43704517
21Tryptophan metabolism_Homo sapiens_hsa003801.43067850
22Homologous recombination_Homo sapiens_hsa034401.38213020
23Protein export_Homo sapiens_hsa030601.36146346
24Regulation of autophagy_Homo sapiens_hsa041401.35701415
25Chemical carcinogenesis_Homo sapiens_hsa052041.34213583
26RNA degradation_Homo sapiens_hsa030181.33415756
27Nucleotide excision repair_Homo sapiens_hsa034201.29184170
28Huntingtons disease_Homo sapiens_hsa050161.28710905
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.26667461
30Arachidonic acid metabolism_Homo sapiens_hsa005901.22484153
31Cardiac muscle contraction_Homo sapiens_hsa042601.22215606
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18906912
33Alzheimers disease_Homo sapiens_hsa050101.15570354
34Hedgehog signaling pathway_Homo sapiens_hsa043401.14234275
35Ether lipid metabolism_Homo sapiens_hsa005651.09358146
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08993311
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08693510
38Tyrosine metabolism_Homo sapiens_hsa003501.07804100
39Arginine biosynthesis_Homo sapiens_hsa002201.07063333
40One carbon pool by folate_Homo sapiens_hsa006701.06472496
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06048463
42Proteasome_Homo sapiens_hsa030501.06006788
43Basal transcription factors_Homo sapiens_hsa030221.03336243
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03109878
45Circadian rhythm_Homo sapiens_hsa047100.99924110
46Fatty acid degradation_Homo sapiens_hsa000710.98625186
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.96449421
48beta-Alanine metabolism_Homo sapiens_hsa004100.94799239
49Sulfur relay system_Homo sapiens_hsa041220.94604480
50Pyruvate metabolism_Homo sapiens_hsa006200.93323723
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89072883
52Purine metabolism_Homo sapiens_hsa002300.86048253
53Fat digestion and absorption_Homo sapiens_hsa049750.85543277
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85416527
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85380430
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85361111
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84770621
58Circadian entrainment_Homo sapiens_hsa047130.83145386
59Mismatch repair_Homo sapiens_hsa034300.82544864
60Taste transduction_Homo sapiens_hsa047420.82434105
61Asthma_Homo sapiens_hsa053100.82248909
62DNA replication_Homo sapiens_hsa030300.82173803
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.80940054
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78944169
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.78169920
66Metabolic pathways_Homo sapiens_hsa011000.78130849
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76368257
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73894868
69GABAergic synapse_Homo sapiens_hsa047270.73825644
70Pyrimidine metabolism_Homo sapiens_hsa002400.72447576
71Glutathione metabolism_Homo sapiens_hsa004800.71328443
72Fatty acid elongation_Homo sapiens_hsa000620.71308052
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70597724
74Retinol metabolism_Homo sapiens_hsa008300.68118657
75Selenocompound metabolism_Homo sapiens_hsa004500.66520020
76Caffeine metabolism_Homo sapiens_hsa002320.66019628
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65977359
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65750603
79Arginine and proline metabolism_Homo sapiens_hsa003300.63222195
80Salivary secretion_Homo sapiens_hsa049700.63154863
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61947357
82Morphine addiction_Homo sapiens_hsa050320.57427569
83Steroid biosynthesis_Homo sapiens_hsa001000.57318668
84Dorso-ventral axis formation_Homo sapiens_hsa043200.56742432
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55951748
86Systemic lupus erythematosus_Homo sapiens_hsa053220.54274559
87Alcoholism_Homo sapiens_hsa050340.53996748
88Collecting duct acid secretion_Homo sapiens_hsa049660.52926106
89Ovarian steroidogenesis_Homo sapiens_hsa049130.52460903
90Fatty acid metabolism_Homo sapiens_hsa012120.49805075
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48953129
92Serotonergic synapse_Homo sapiens_hsa047260.48309182
93Basal cell carcinoma_Homo sapiens_hsa052170.47783842
94Phenylalanine metabolism_Homo sapiens_hsa003600.47144332
95Mineral absorption_Homo sapiens_hsa049780.46343603
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.46225170
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45798789
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44686264
99Oxytocin signaling pathway_Homo sapiens_hsa049210.44600145
100Carbon metabolism_Homo sapiens_hsa012000.43785255

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