ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	growth hormone secretion (GO:0030252)	9.42916334
2	positive regulation of growth hormone secretion (GO:0060124)	8.50898856
3	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	6.19718641
4	response to muscle activity (GO:0014850)	6.09175986
5	regulation of growth hormone secretion (GO:0060123)	6.06744111
6	positive regulation of catecholamine secretion (GO:0033605)	5.92712147
7	positive regulation of oligodendrocyte differentiation (GO:0048714)	5.75829522
8	coenzyme catabolic process (GO:0009109)	5.34680782
9	ADP metabolic process (GO:0046031)	5.21489596
10	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	5.16964047
11	behavioral response to nicotine (GO:0035095)	5.13605197
12	cellular response to zinc ion (GO:0071294)	5.03119910
13	positive regulation of circadian rhythm (GO:0042753)	4.96057526
14	regulation of autophagic vacuole assembly (GO:2000785)	4.93525341
15	regulation of oxidative stress-induced neuron death (GO:1903203)	4.73819847
16	regulation of oxidative phosphorylation (GO:0002082)	4.72675493
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.66172024
18	regulation of circadian sleep/wake cycle, sleep (GO:0045187)	4.54533515
19	regulation of circadian sleep/wake cycle (GO:0042749)	4.54533515
20	circadian sleep/wake cycle process (GO:0022410)	4.39981849
21	thalamus development (GO:0021794)	4.34185455
22	response to food (GO:0032094)	4.27287213
23	mRNA cleavage (GO:0006379)	4.16801802
24	muscle cell cellular homeostasis (GO:0046716)	4.15959521
25	regulation of vacuole organization (GO:0044088)	4.14647129
26	regulation of cellular respiration (GO:0043457)	4.11466737
27	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	4.11151739
28	type B pancreatic cell development (GO:0003323)	4.07119634
29	negative regulation of telomere maintenance (GO:0032205)	4.00464386
30	nucleoside diphosphate phosphorylation (GO:0006165)	4.00171208
31	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.99578432
32	AMP metabolic process (GO:0046033)	3.87578583
33	epithelial cilium movement (GO:0003351)	3.86043535
34	activation of protein kinase B activity (GO:0032148)	3.82142898
35	sulfation (GO:0051923)	3.74982325
36	circadian behavior (GO:0048512)	3.70391861
37	regulation of dopamine secretion (GO:0014059)	3.66600679
38	parturition (GO:0007567)	3.64479341
39	positive regulation of protein kinase C signaling (GO:0090037)	3.58287077
40	myofibril assembly (GO:0030239)	3.55451203
41	kidney morphogenesis (GO:0060993)	3.55091598
42	cellular response to cadmium ion (GO:0071276)	3.53056592
43	pyrimidine nucleobase catabolic process (GO:0006208)	3.49109733
44	glycerophospholipid catabolic process (GO:0046475)	3.47067642
45	muscle fiber development (GO:0048747)	3.43840702
46	neuromuscular synaptic transmission (GO:0007274)	3.40823178
47	rhythmic behavior (GO:0007622)	3.40242040
48	tongue development (GO:0043586)	3.35858960
49	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.34181530
50	forebrain neuron differentiation (GO:0021879)	3.26185112
51	motile cilium assembly (GO:0044458)	3.23415126
52	nucleoside diphosphate biosynthetic process (GO:0009133)	3.19863312
53	positive regulation of glial cell differentiation (GO:0045687)	3.17723146
54	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.16600904
55	ganglion development (GO:0061548)	3.16433642
56	uterus development (GO:0060065)	3.15023829
57	regulation of phospholipase A2 activity (GO:0032429)	3.14191478
58	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.12281986
59	cardiac ventricle formation (GO:0003211)	3.11810152
60	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.08831313
61	substrate-independent telencephalic tangential migration (GO:0021826)	3.08831313
62	paraxial mesoderm development (GO:0048339)	3.07121629
63	positive regulation of p38MAPK cascade (GO:1900745)	3.06365318
64	negative regulation of organelle assembly (GO:1902116)	3.05287058
65	oligosaccharide biosynthetic process (GO:0009312)	3.04797813
66	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.04529873
67	mitochondrion degradation (GO:0000422)	3.01679449
68	forebrain morphogenesis (GO:0048853)	3.01336106
69	axonal fasciculation (GO:0007413)	3.00132419
70	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.99509736
71	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.99192843
72	activation of MAPKKK activity (GO:0000185)	2.97788783
73	xenobiotic catabolic process (GO:0042178)	2.97155724
74	cardiac muscle cell proliferation (GO:0060038)	2.96561500
75	regulation of cofactor metabolic process (GO:0051193)	2.94335039
76	regulation of coenzyme metabolic process (GO:0051196)	2.94335039
77	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.93788734
78	postsynaptic membrane organization (GO:0001941)	2.93650691
79	phenylpropanoid metabolic process (GO:0009698)	2.92305628
80	limb bud formation (GO:0060174)	2.91773076
81	cilium movement (GO:0003341)	2.91061505
82	striated muscle cell proliferation (GO:0014855)	2.90656232
83	dentate gyrus development (GO:0021542)	2.90419580
84	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.86823345
85	muscle cell fate commitment (GO:0042693)	2.86574957
86	neuron fate commitment (GO:0048663)	2.83569044
87	negative regulation of amino acid transport (GO:0051956)	2.81822209
88	cardiac chamber formation (GO:0003207)	2.81006868
89	relaxation of smooth muscle (GO:0044557)	2.80253618
90	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.80018125
91	myoblast migration (GO:0051451)	2.78790507
92	pyrimidine dimer repair (GO:0006290)	2.77326745
93	cGMP-mediated signaling (GO:0019934)	2.76835027
94	spinal cord association neuron differentiation (GO:0021527)	2.76416664
95	regulation of myoblast differentiation (GO:0045661)	2.73977471
96	drinking behavior (GO:0042756)	2.73861063
97	negative regulation of DNA binding (GO:0043392)	2.71134166
98	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.68859039
99	regulation of gene silencing by miRNA (GO:0060964)	2.68261140
100	regulation of gene silencing by RNA (GO:0060966)	2.68261140

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	7.35327018
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.74435133
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	4.26461970
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.22766339
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.81050477
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.41393833
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93482221
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.88623510
9	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.79596400
10	VDR_22108803_ChIP-Seq_LS180_Human	2.63852723
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.59754130
12	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.44232710
13	AR_21572438_ChIP-Seq_LNCaP_Human	2.23594230
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.12541279
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.96059512
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87139717
17	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.83005055
18	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.79384551
19	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.78407283
20	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.78184885
21	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73529355
22	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.73529355
23	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.68960506
24	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.68960506
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66249966
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.65419127
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.64594113
28	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.64096746
29	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.56472097
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.50166257
31	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.46238723
32	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.45034042
33	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.43427313
34	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.42858929
35	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.42168201
36	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.41357708
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.41325079
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.39971592
39	RXR_22108803_ChIP-Seq_LS180_Human	1.36114077
40	CTCF_27219007_Chip-Seq_Bcells_Human	1.34486291
41	NANOG_20526341_ChIP-Seq_ESCs_Human	1.33712968
42	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.31407331
43	P300_19829295_ChIP-Seq_ESCs_Human	1.29244273
44	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.27809174
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27133796
46	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.26722601
47	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.25555357
48	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.23981681
49	RAC3_21632823_ChIP-Seq_H3396_Human	1.23794967
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21972671
51	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.21506650
52	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.15868029
53	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.14354895
54	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.14303435
55	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14199794
56	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11966228
57	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.11219802
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.10107489
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09167311
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08898149
61	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08122375
62	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.06729809
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06217535
64	ERA_21632823_ChIP-Seq_H3396_Human	1.04457621
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02960470
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00850225
67	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.99808199
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99256654
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98873266
70	CBP_20019798_ChIP-Seq_JUKART_Human	0.98873266
71	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.97522209
72	RNF2_27304074_Chip-Seq_NSC_Mouse	0.95661695
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95370853
74	NCOR_22424771_ChIP-Seq_293T_Human	0.93776074
75	SMAD4_21799915_ChIP-Seq_A2780_Human	0.93526402
76	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.92790527
77	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.91762317
78	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.90447067
79	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.88592029
80	AR_25329375_ChIP-Seq_VCAP_Human	0.88150144
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.86965477
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.86468187
83	CBP_21632823_ChIP-Seq_H3396_Human	0.86015728
84	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.84986601
85	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.83948161
86	FUS_26573619_Chip-Seq_HEK293_Human	0.83849170
87	HOXB7_26014856_ChIP-Seq_BT474_Human	0.83838490
88	SPI1_20517297_ChIP-Seq_HL60_Human	0.79804719
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.78611396
90	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.78336642
91	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.78240030
92	AHR_22903824_ChIP-Seq_MCF-7_Human	0.77210867
93	CTCF_20526341_ChIP-Seq_ESCs_Human	0.75682582
94	OCT4_20526341_ChIP-Seq_ESCs_Human	0.75097235
95	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.74422697
96	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.74013880
97	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.73995160
98	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.73290310
99	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.72360317
100	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.72108209

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000749_muscle_degeneration	4.10039475
2	MP0003136_yellow_coat_color	3.82301769
3	MP0003806_abnormal_nucleotide_metabolis	3.59002766
4	MP0002837_dystrophic_cardiac_calcinosis	3.46403531
5	MP0002163_abnormal_gland_morphology	3.03062166
6	MP0002102_abnormal_ear_morphology	2.91544208
7	MP0003315_abnormal_perineum_morphology	2.88008795
8	MP0002160_abnormal_reproductive_system	2.83208131
9	MP0001502_abnormal_circadian_rhythm	2.77800994
10	MP0005499_abnormal_olfactory_system	2.64623786
11	MP0005394_taste/olfaction_phenotype	2.64623786
12	MP0004084_abnormal_cardiac_muscle	2.56564045
13	MP0008004_abnormal_stomach_pH	2.51841083
14	MP0008789_abnormal_olfactory_epithelium	2.46404920
15	MP0005187_abnormal_penis_morphology	2.36421573
16	MP0001968_abnormal_touch/_nociception	2.32624137
17	MP0002132_abnormal_respiratory_system	2.32580320
18	MP0001529_abnormal_vocalization	2.18642405
19	MP0002653_abnormal_ependyma_morphology	2.08904633
20	MP0001905_abnormal_dopamine_level	2.01064477
21	MP0006072_abnormal_retinal_apoptosis	1.99593591
22	MP0005451_abnormal_body_composition	1.97282820
23	MP0003787_abnormal_imprinting	1.95667470
24	MP0003122_maternal_imprinting	1.89555811
25	MP0001485_abnormal_pinna_reflex	1.83735256
26	MP0004036_abnormal_muscle_relaxation	1.69986479
27	MP0009697_abnormal_copulation	1.65802221
28	MP0010386_abnormal_urinary_bladder	1.58708304
29	MP0004272_abnormal_basement_membrane	1.58681670
30	MP0005379_endocrine/exocrine_gland_phen	1.57354339
31	MP0002736_abnormal_nociception_after	1.54666206
32	MP0001984_abnormal_olfaction	1.52631008
33	MP0002233_abnormal_nose_morphology	1.51668613
34	MP0005167_abnormal_blood-brain_barrier	1.43710461
35	MP0005330_cardiomyopathy	1.42378238
36	MP0001664_abnormal_digestion	1.42287721
37	MP0001188_hyperpigmentation	1.41803272
38	MP0006036_abnormal_mitochondrial_physio	1.40599741
39	MP0003123_paternal_imprinting	1.40503987
40	MP0004142_abnormal_muscle_tone	1.39699874
41	MP0001270_distended_abdomen	1.34581035
42	MP0000537_abnormal_urethra_morphology	1.34284523
43	MP0003880_abnormal_central_pattern	1.31801043
44	MP0002249_abnormal_larynx_morphology	1.23006368
45	MP0009250_abnormal_appendicular_skeleto	1.22177702
46	MP0001849_ear_inflammation	1.20656115
47	MP0000778_abnormal_nervous_system	1.18650120
48	MP0001299_abnormal_eye_distance/	1.16524240
49	MP0001501_abnormal_sleep_pattern	1.14896291
50	MP0000049_abnormal_middle_ear	1.14207246
51	MP0003385_abnormal_body_wall	1.13587487
52	MP0010368_abnormal_lymphatic_system	1.13363095
53	MP0005389_reproductive_system_phenotype	1.13206285
54	MP0004215_abnormal_myocardial_fiber	1.12266868
55	MP0002272_abnormal_nervous_system	1.10421565
56	MP0003879_abnormal_hair_cell	1.08646698
57	MP0005266_abnormal_metabolism	1.06043513
58	MP0002269_muscular_atrophy	1.04826251
59	MP0002067_abnormal_sensory_capabilities	1.04074530
60	MP0002127_abnormal_cardiovascular_syste	1.03485106
61	MP0000230_abnormal_systemic_arterial	1.01182674
62	MP0009046_muscle_twitch	1.00938002
63	MP0006292_abnormal_olfactory_placode	0.99830378
64	MP0002108_abnormal_muscle_morphology	0.96651922
65	MP0005620_abnormal_muscle_contractility	0.95975801
66	MP0005253_abnormal_eye_physiology	0.92113796
67	MP0004742_abnormal_vestibular_system	0.90547181
68	MP0000759_abnormal_skeletal_muscle	0.88921099
69	MP0004381_abnormal_hair_follicle	0.85554331
70	MP0002752_abnormal_somatic_nervous	0.82674034
71	MP0003137_abnormal_impulse_conducting	0.78711893
72	MP0005448_abnormal_energy_balance	0.78094474
73	MP0008995_early_reproductive_senescence	0.77920578
74	MP0003878_abnormal_ear_physiology	0.77651156
75	MP0005377_hearing/vestibular/ear_phenot	0.77651156
76	MP0003635_abnormal_synaptic_transmissio	0.77625815
77	MP0008775_abnormal_heart_ventricle	0.77074715
78	MP0009745_abnormal_behavioral_response	0.75586426
79	MP0003828_pulmonary_edema	0.75005101
80	MP0004085_abnormal_heartbeat	0.74401994
81	MP0005058_abnormal_lysosome_morphology	0.74391881
82	MP0001544_abnormal_cardiovascular_syste	0.73060957
83	MP0005385_cardiovascular_system_phenoty	0.73060957
84	MP0002557_abnormal_social/conspecific_i	0.71412164
85	MP0002693_abnormal_pancreas_physiology	0.67896621
86	MP0002069_abnormal_eating/drinking_beha	0.67285289
87	MP0004859_abnormal_synaptic_plasticity	0.66946715
88	MP0000750_abnormal_muscle_regeneration	0.66706342
89	MP0000631_abnormal_neuroendocrine_gland	0.64935795
90	MP0003938_abnormal_ear_development	0.64613593
91	MP0000026_abnormal_inner_ear	0.64367022
92	MP0005391_vision/eye_phenotype	0.64127214
93	MP0002063_abnormal_learning/memory/cond	0.63133875
94	MP0001486_abnormal_startle_reflex	0.62955228
95	MP0004133_heterotaxia	0.62533150
96	MP0001340_abnormal_eyelid_morphology	0.62287805
97	MP0010030_abnormal_orbit_morphology	0.61929494
98	MP0002090_abnormal_vision	0.61838004
99	MP0002572_abnormal_emotion/affect_behav	0.60653995
100	MP0005646_abnormal_pituitary_gland	0.60181386

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatoblastoma (HP:0002884)	5.45544123
2	Abnormality of the columella (HP:0009929)	4.98464419
3	Clumsiness (HP:0002312)	4.94008857
4	Exercise-induced muscle cramps (HP:0003710)	4.41306249
5	Scapular winging (HP:0003691)	3.93309513
6	Reduced antithrombin III activity (HP:0001976)	3.92710667
7	Rimmed vacuoles (HP:0003805)	3.89914854
8	Hyporeflexia of lower limbs (HP:0002600)	3.80579889
9	Abnormality of the shoulder girdle musculature (HP:0001435)	3.80555992
10	Neoplasm of the adrenal cortex (HP:0100641)	3.76623355
11	Premature ovarian failure (HP:0008209)	3.68075820
12	Eosinophilia (HP:0001880)	3.48371153
13	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.29323147
14	Diaphragmatic weakness (HP:0009113)	3.19081915
15	Unsteady gait (HP:0002317)	3.00432497
16	Abnormality of DNA repair (HP:0003254)	2.97273812
17	Myoglobinuria (HP:0002913)	2.94518991
18	Abnormal ciliary motility (HP:0012262)	2.88306897
19	Abnormal respiratory motile cilium morphology (HP:0005938)	2.87452692
20	Abnormal respiratory epithelium morphology (HP:0012253)	2.87452692
21	Hypoplastic pelvis (HP:0008839)	2.85414181
22	Urinary urgency (HP:0000012)	2.82109561
23	Cerebral hypomyelination (HP:0006808)	2.79832830
24	Inability to walk (HP:0002540)	2.78477278
25	Epidermoid cyst (HP:0200040)	2.78359112
26	Abnormality of the calf musculature (HP:0001430)	2.71698335
27	Absent/shortened dynein arms (HP:0200106)	2.70508282
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.70508282
29	Retinal dysplasia (HP:0007973)	2.70115423
30	Exercise-induced myalgia (HP:0003738)	2.69771885
31	Abnormal pancreas size (HP:0012094)	2.66796085
32	Proximal amyotrophy (HP:0007126)	2.66722001
33	Enlarged kidneys (HP:0000105)	2.63324145
34	Adrenal hypoplasia (HP:0000835)	2.62074867
35	High anterior hairline (HP:0009890)	2.61137203
36	Granulocytopenia (HP:0001913)	2.60702256
37	Weak cry (HP:0001612)	2.54945909
38	Abnormality of eosinophils (HP:0001879)	2.50918629
39	Calf muscle hypertrophy (HP:0008981)	2.49245755
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.48880443
41	Duplicated collecting system (HP:0000081)	2.39371288
42	Nonprogressive disorder (HP:0003680)	2.37474027
43	Abnormality of the renal collecting system (HP:0004742)	2.33145842
44	Resting tremor (HP:0002322)	2.33029266
45	Abnormality of the pubic bones (HP:0003172)	2.27234836
46	EMG: myopathic abnormalities (HP:0003458)	2.26212407
47	Type II lissencephaly (HP:0007260)	2.25650706
48	Muscle hypertrophy of the lower extremities (HP:0008968)	2.22621248
49	Anterior segment dysgenesis (HP:0007700)	2.22328254
50	Rhabdomyolysis (HP:0003201)	2.19467245
51	Cupped ear (HP:0000378)	2.14358472
52	Partial duplication of thumb phalanx (HP:0009944)	2.12211722
53	Renal dysplasia (HP:0000110)	2.11354465
54	CNS hypomyelination (HP:0003429)	2.09636095
55	Intestinal atresia (HP:0011100)	2.09288703
56	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.09220875
57	Abnormal respiratory motile cilium physiology (HP:0012261)	2.08962507
58	Spinal rigidity (HP:0003306)	2.06636326
59	Metaphyseal dysplasia (HP:0100255)	2.06553104
60	Myopathic facies (HP:0002058)	2.06009336
61	Type 2 muscle fiber atrophy (HP:0003554)	2.04545639
62	Short chin (HP:0000331)	2.04473800
63	Duplication of thumb phalanx (HP:0009942)	2.04445562
64	Abnormality of the ileum (HP:0001549)	2.00052346
65	Right ventricular cardiomyopathy (HP:0011663)	1.99527300
66	Optic nerve hypoplasia (HP:0000609)	1.99022424
67	Abnormal biliary tract physiology (HP:0012439)	1.98439306
68	Bile duct proliferation (HP:0001408)	1.98439306
69	Aortic aneurysm (HP:0004942)	1.97007693
70	Facial hemangioma (HP:0000329)	1.96970198
71	Epiphyseal dysplasia (HP:0002656)	1.94733688
72	Diastasis recti (HP:0001540)	1.93756468
73	Secondary amenorrhea (HP:0000869)	1.93437878
74	Absent thumb (HP:0009777)	1.93400846
75	Ulnar claw (HP:0001178)	1.93333703
76	Retinal atrophy (HP:0001105)	1.92043163
77	Hypoplastic nipples (HP:0002557)	1.91148162
78	Self-mutilation (HP:0000742)	1.89834052
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89107250
80	Abnormality of the frontal sinuses (HP:0002687)	1.85956251
81	Steppage gait (HP:0003376)	1.85930438
82	Pancreatic fibrosis (HP:0100732)	1.85190905
83	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.84282363
84	Neonatal hypoglycemia (HP:0001998)	1.83865641
85	Oligodactyly (hands) (HP:0001180)	1.83368930
86	Aplasia involving forearm bones (HP:0009822)	1.81338508
87	Absent forearm bone (HP:0003953)	1.81338508
88	Difficulty walking (HP:0002355)	1.81050443
89	Muscular dystrophy (HP:0003560)	1.80566050
90	Frequent falls (HP:0002359)	1.79884911
91	Irregular vertebral endplates (HP:0003301)	1.79560787
92	Bulbar palsy (HP:0001283)	1.78987978
93	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.77087670
94	Meckel diverticulum (HP:0002245)	1.76786788
95	Ventricular fibrillation (HP:0001663)	1.76406280
96	Sensory axonal neuropathy (HP:0003390)	1.75835544
97	Neoplasm of the adrenal gland (HP:0100631)	1.75096608
98	Thoracic kyphosis (HP:0002942)	1.74802321
99	Nasal speech (HP:0001611)	1.74724256
100	Difficulty running (HP:0009046)	1.74541653

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	8.57940253
2	OBSCN	3.85883128
3	MARK3	3.72724247
4	MAP2K7	3.29542697
5	FRK	2.99703091
6	EPHA3	2.41461465
7	NEK2	2.39295271
8	EPHA4	2.20835499
9	ARAF	2.08796754
10	LATS1	2.05530884
11	TLK1	2.02040270
12	BMPR1B	1.92602216
13	ICK	1.91478872
14	RPS6KA4	1.86294396
15	STK38L	1.75437230
16	ZAK	1.68434937
17	CSNK1A1L	1.66666031
18	MYLK	1.62046584
19	IRAK2	1.60840471
20	MAP3K9	1.49206029
21	ADRBK2	1.46415234
22	CDK3	1.44220741
23	MAPK15	1.39128506
24	TIE1	1.37553795
25	CDK8	1.32612725
26	CSNK1G3	1.25891533
27	DYRK3	1.22568818
28	MOS	1.20105323
29	MAP3K7	1.18329455
30	TGFBR1	1.13923235
31	MAP3K1	1.13356266
32	CSNK1G2	1.02567825
33	CSNK1G1	1.01957818
34	DYRK2	0.98691958
35	BCKDK	0.96979439
36	SGK223	0.92199390
37	SGK494	0.92199390
38	SIK2	0.91680959
39	BCR	0.89698595
40	PRKG2	0.85623934
41	RAF1	0.84007708
42	CCNB1	0.80599829
43	PRKCQ	0.80207631
44	GRK1	0.79969859
45	GRK7	0.79591843
46	BTK	0.77552328
47	DAPK3	0.76010600
48	RPS6KB1	0.74211396
49	MAP3K4	0.73956069
50	CAMKK2	0.73821458
51	RPS6KA5	0.72660724
52	MAPKAPK3	0.72565491
53	LATS2	0.71882136
54	CAMK1	0.71880282
55	NME1	0.71338286
56	MAP3K13	0.70722453
57	NME2	0.69410825
58	KSR2	0.65092707
59	CDK19	0.61645524
60	MUSK	0.59716942
61	ILK	0.58873160
62	PHKG2	0.54404337
63	PHKG1	0.54404337
64	STK38	0.52009716
65	SGK2	0.51888135
66	IRAK1	0.51559591
67	ROCK1	0.50541111
68	PAK1	0.49473467
69	RET	0.47566918
70	MAP3K5	0.47455465
71	MAP3K10	0.47286411
72	MARK2	0.47083476
73	CAMK4	0.44259939
74	PTK2B	0.44137321
75	MAPK12	0.43545864
76	PKN1	0.42282407
77	MAPK13	0.41719981
78	KSR1	0.39908964
79	CDK14	0.36342441
80	PRKAA1	0.35963791
81	CDK5	0.35560956
82	TAOK3	0.32658618
83	FGR	0.31539858
84	PAK6	0.30444051
85	STK11	0.30383669
86	NTRK2	0.30056659
87	ROCK2	0.29697032
88	ADRBK1	0.29411074
89	DAPK2	0.28952639
90	EPHB1	0.28391846
91	FGFR2	0.28367275
92	CSNK1A1	0.28199918
93	SGK3	0.24440052
94	PRKCG	0.22843045
95	PLK2	0.21553014
96	AKT2	0.21505594
97	BLK	0.21212455
98	CAMK2B	0.20210614
99	SRPK1	0.19329005
100	PRKACB	0.19075948

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	4.06428087
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.94867769
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.73622341
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.37321947
5	Butanoate metabolism_Homo sapiens_hsa00650	2.27808550
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.22442924
7	Chemical carcinogenesis_Homo sapiens_hsa05204	2.03704451
8	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.97781497
9	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.95905994
10	Regulation of autophagy_Homo sapiens_hsa04140	1.92507210
11	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.86544449
12	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.81553529
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.79604367
14	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.76088117
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66536959
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.65804495
17	Circadian rhythm_Homo sapiens_hsa04710	1.51313699
18	Peroxisome_Homo sapiens_hsa04146	1.44422310
19	Phototransduction_Homo sapiens_hsa04744	1.40128751
20	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.37276142
21	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.36752179
22	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.36454602
23	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.29271813
24	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.27956444
25	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.26712687
26	Circadian entrainment_Homo sapiens_hsa04713	1.26293750
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.20070425
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.18741295
29	Arginine and proline metabolism_Homo sapiens_hsa00330	1.18411102
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.17996342
31	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.14242747
32	Arginine biosynthesis_Homo sapiens_hsa00220	1.14055923
33	Sulfur relay system_Homo sapiens_hsa04122	1.11306965
34	Mineral absorption_Homo sapiens_hsa04978	1.11228341
35	Renin secretion_Homo sapiens_hsa04924	1.08635100
36	Salivary secretion_Homo sapiens_hsa04970	1.07510700
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02924461
38	AMPK signaling pathway_Homo sapiens_hsa04152	0.99835304
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.99299666
40	Taste transduction_Homo sapiens_hsa04742	0.99152892
41	Calcium signaling pathway_Homo sapiens_hsa04020	0.97769748
42	Cardiac muscle contraction_Homo sapiens_hsa04260	0.97238697
43	Purine metabolism_Homo sapiens_hsa00230	0.96696715
44	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.96660877
45	Phenylalanine metabolism_Homo sapiens_hsa00360	0.96426225
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.95561139
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94851981
48	Fatty acid degradation_Homo sapiens_hsa00071	0.94223234
49	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.92675126
50	Glucagon signaling pathway_Homo sapiens_hsa04922	0.90421455
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89498149
52	Basal cell carcinoma_Homo sapiens_hsa05217	0.88803866
53	Melanoma_Homo sapiens_hsa05218	0.86397164
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.86039390
55	Nicotine addiction_Homo sapiens_hsa05033	0.83870319
56	Propanoate metabolism_Homo sapiens_hsa00640	0.81891072
57	MAPK signaling pathway_Homo sapiens_hsa04010	0.80893295
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80126450
59	FoxO signaling pathway_Homo sapiens_hsa04068	0.77946033
60	Platelet activation_Homo sapiens_hsa04611	0.77154867
61	Gastric acid secretion_Homo sapiens_hsa04971	0.75853349
62	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.75327797
63	Fanconi anemia pathway_Homo sapiens_hsa03460	0.75007400
64	Glutathione metabolism_Homo sapiens_hsa00480	0.74540581
65	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.72776624
66	Wnt signaling pathway_Homo sapiens_hsa04310	0.69830323
67	GABAergic synapse_Homo sapiens_hsa04727	0.67560325
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.66655003
69	VEGF signaling pathway_Homo sapiens_hsa04370	0.62611790
70	ABC transporters_Homo sapiens_hsa02010	0.62311276
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.61172639
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.60979152
73	RNA polymerase_Homo sapiens_hsa03020	0.60488089
74	Long-term depression_Homo sapiens_hsa04730	0.60291061
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56886362
76	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55344475
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.51516682
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50529666
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.50516502
80	Retinol metabolism_Homo sapiens_hsa00830	0.49990121
81	Metabolic pathways_Homo sapiens_hsa01100	0.49888319
82	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.49411457
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49218264
84	PPAR signaling pathway_Homo sapiens_hsa03320	0.49199900
85	Gap junction_Homo sapiens_hsa04540	0.48523611
86	Parkinsons disease_Homo sapiens_hsa05012	0.48081806
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.47914571
88	Melanogenesis_Homo sapiens_hsa04916	0.47046821
89	Ribosome_Homo sapiens_hsa03010	0.47010575
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.46545848
91	Cocaine addiction_Homo sapiens_hsa05030	0.45063423
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44040673
93	Axon guidance_Homo sapiens_hsa04360	0.42337474
94	Cholinergic synapse_Homo sapiens_hsa04725	0.41582097
95	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.40778673
96	Serotonergic synapse_Homo sapiens_hsa04726	0.40650642
97	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40406590
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.38871889
99	Insulin secretion_Homo sapiens_hsa04911	0.38866575
100	Tryptophan metabolism_Homo sapiens_hsa00380	0.37895755

GLUD1P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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