GLUD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA methylation (GO:0031167)4.25384502
2rRNA modification (GO:0000154)4.24735368
3bile acid biosynthetic process (GO:0006699)4.08196556
4cellular ketone body metabolic process (GO:0046950)4.04400675
5cellular glucuronidation (GO:0052695)3.88920196
6uronic acid metabolic process (GO:0006063)3.87857946
7glucuronate metabolic process (GO:0019585)3.87857946
8heme transport (GO:0015886)3.81371342
9cysteine metabolic process (GO:0006534)3.79896360
10serine family amino acid catabolic process (GO:0009071)3.75135182
11ketone body metabolic process (GO:1902224)3.68828938
12positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.61030758
13male meiosis (GO:0007140)3.58475353
14glyoxylate metabolic process (GO:0046487)3.57859190
15L-phenylalanine catabolic process (GO:0006559)3.57759408
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.57759408
17L-phenylalanine metabolic process (GO:0006558)3.46197590
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.46197590
19positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.45362890
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38766358
21flavonoid metabolic process (GO:0009812)3.36474083
22xenobiotic catabolic process (GO:0042178)3.30534003
23sulfur amino acid catabolic process (GO:0000098)3.29689052
24aminoglycoside antibiotic metabolic process (GO:0030647)3.29035408
25glycine metabolic process (GO:0006544)3.28855409
26regulation of plasminogen activation (GO:0010755)3.27265487
27daunorubicin metabolic process (GO:0044597)3.23465922
28polyketide metabolic process (GO:0030638)3.23465922
29doxorubicin metabolic process (GO:0044598)3.23465922
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23192324
31synapsis (GO:0007129)3.22324498
32homocysteine metabolic process (GO:0050667)3.19001921
33ribosomal small subunit assembly (GO:0000028)3.15533284
34serine family amino acid biosynthetic process (GO:0009070)3.13062901
35serine family amino acid metabolic process (GO:0009069)3.11028118
36binding of sperm to zona pellucida (GO:0007339)3.05452309
37bile acid metabolic process (GO:0008206)3.04792086
38epithelial cilium movement (GO:0003351)3.04336654
39organic cation transport (GO:0015695)3.04086467
40glutathione derivative biosynthetic process (GO:1901687)3.02903310
41glutathione derivative metabolic process (GO:1901685)3.02903310
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.01316433
43ATP synthesis coupled proton transport (GO:0015986)3.01316433
44maturation of SSU-rRNA (GO:0030490)2.99329150
45proteasome assembly (GO:0043248)2.98812275
46positive regulation of catecholamine secretion (GO:0033605)2.98023497
47aromatic amino acid family catabolic process (GO:0009074)2.95904758
48polyamine biosynthetic process (GO:0006596)2.95819134
49regulation of bile acid biosynthetic process (GO:0070857)2.95011648
50L-methionine salvage (GO:0071267)2.88721507
51L-methionine biosynthetic process (GO:0071265)2.88721507
52amino acid salvage (GO:0043102)2.88721507
53cholesterol efflux (GO:0033344)2.87752705
54protein carboxylation (GO:0018214)2.87368854
55peptidyl-glutamic acid carboxylation (GO:0017187)2.87368854
56axonemal dynein complex assembly (GO:0070286)2.86596234
57C21-steroid hormone metabolic process (GO:0008207)2.86480526
58ribosomal small subunit biogenesis (GO:0042274)2.86397166
59establishment of protein localization to mitochondrial membrane (GO:0090151)2.82821949
60intestinal cholesterol absorption (GO:0030299)2.81388428
61ovulation from ovarian follicle (GO:0001542)2.78844379
62high-density lipoprotein particle remodeling (GO:0034375)2.78193153
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.77244652
64glucosamine-containing compound catabolic process (GO:1901072)2.74957765
65polyamine metabolic process (GO:0006595)2.74810038
66sulfur amino acid biosynthetic process (GO:0000097)2.73713393
67progesterone metabolic process (GO:0042448)2.72726376
68regulation of cholesterol esterification (GO:0010872)2.72644045
69regulation of oxidative phosphorylation (GO:0002082)2.72504118
70cilium movement (GO:0003341)2.71229655
71viral transcription (GO:0019083)2.70041239
72acylglycerol homeostasis (GO:0055090)2.69062466
73triglyceride homeostasis (GO:0070328)2.69062466
74translational termination (GO:0006415)2.69005522
75regulation of cellular respiration (GO:0043457)2.68356042
76cholesterol catabolic process (GO:0006707)2.67702791
77sterol catabolic process (GO:0016127)2.67702791
78sulfation (GO:0051923)2.66243365
79positive regulation of glycolytic process (GO:0045821)2.62304734
80plasma lipoprotein particle clearance (GO:0034381)2.58732481
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57374651
82low-density lipoprotein particle remodeling (GO:0034374)2.56745490
83cilium or flagellum-dependent cell motility (GO:0001539)2.55895929
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.55351886
85coenzyme catabolic process (GO:0009109)2.54836788
86sperm-egg recognition (GO:0035036)2.53198226
87negative regulation of fibrinolysis (GO:0051918)2.52904871
88mesenchymal cell proliferation (GO:0010463)2.50802078
89electron transport chain (GO:0022900)2.50312318
90IMP biosynthetic process (GO:0006188)2.50190852
91* alpha-amino acid catabolic process (GO:1901606)2.49557648
92multicellular organism reproduction (GO:0032504)2.49474461
93fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.49437056
94respiratory electron transport chain (GO:0022904)2.49173406
95SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.48501242
96translational elongation (GO:0006414)2.48371083
97spermatid development (GO:0007286)2.48027585
98histone exchange (GO:0043486)2.46463118
99motile cilium assembly (GO:0044458)2.46119688
100cotranslational protein targeting to membrane (GO:0006613)2.45421470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.21316771
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.36612920
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.99662211
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44362411
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.40179368
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.34687798
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.99181499
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.95759871
9VDR_22108803_ChIP-Seq_LS180_Human2.65399185
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.56819208
11FUS_26573619_Chip-Seq_HEK293_Human2.25660411
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.19275070
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14762544
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12171085
15IGF1R_20145208_ChIP-Seq_DFB_Human2.05549988
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.95718335
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.92502596
18ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88300796
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75060426
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75014278
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73902344
22ELK1_19687146_ChIP-ChIP_HELA_Human1.71607898
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67058655
24ZNF274_21170338_ChIP-Seq_K562_Hela1.64490575
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.63077640
26AR_21909140_ChIP-Seq_LNCAP_Human1.59709638
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58723894
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51641541
29ER_23166858_ChIP-Seq_MCF-7_Human1.51256648
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45865013
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40518846
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40156212
33IRF1_19129219_ChIP-ChIP_H3396_Human1.39277288
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38898952
35DCP1A_22483619_ChIP-Seq_HELA_Human1.37286750
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35640734
37XRN2_22483619_ChIP-Seq_HELA_Human1.35528175
38VDR_23849224_ChIP-Seq_CD4+_Human1.35087109
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34774374
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33971475
41EWS_26573619_Chip-Seq_HEK293_Human1.33566432
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30859570
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30494032
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30191493
45MYC_18940864_ChIP-ChIP_HL60_Human1.30125833
46FOXP3_21729870_ChIP-Seq_TREG_Human1.29780167
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.28650050
48ERG_20517297_ChIP-Seq_VCAP_Human1.27945577
49GBX2_23144817_ChIP-Seq_PC3_Human1.27314520
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25479992
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25058186
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24103755
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.23982889
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22090991
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.21265448
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20228400
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18782419
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.18533111
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17655534
60SOX17_20123909_ChIP-Seq_XEN_Mouse1.17148278
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17048334
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16753220
63SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16634027
64HTT_18923047_ChIP-ChIP_STHdh_Human1.07940034
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.07775885
66TTF2_22483619_ChIP-Seq_HELA_Human1.07722497
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05763555
68BCAT_22108803_ChIP-Seq_LS180_Human1.05506690
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04700573
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04411665
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04080760
72GABP_19822575_ChIP-Seq_HepG2_Human1.03147342
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01696970
74* P300_19829295_ChIP-Seq_ESCs_Human1.01529443
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01294757
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98865630
77E2F7_22180533_ChIP-Seq_HELA_Human0.98350822
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96588417
79* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96194022
80PHF8_20622853_ChIP-Seq_HELA_Human0.93916032
81NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93322214
82AR_20517297_ChIP-Seq_VCAP_Human0.90647129
83CBP_20019798_ChIP-Seq_JUKART_Human0.90198066
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90198066
85CBP_21632823_ChIP-Seq_H3396_Human0.89472231
86NCOR_22424771_ChIP-Seq_293T_Human0.88474811
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87265772
88CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85971312
89KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85264960
90NANOG_19829295_ChIP-Seq_ESCs_Human0.84919735
91SOX2_19829295_ChIP-Seq_ESCs_Human0.84919735
92PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84907729
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84703890
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84672650
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.83575065
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83010757
97HNFA_21074721_ChIP-Seq_CACO-2_Human0.81468991
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.81202764
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80004409
100RNF2_27304074_Chip-Seq_NSC_Mouse0.77747922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.97619150
2MP0005360_urolithiasis3.34243794
3MP0003315_abnormal_perineum_morphology3.23101290
4MP0003806_abnormal_nucleotide_metabolis3.05762647
5MP0005085_abnormal_gallbladder_physiolo2.91147429
6MP0005365_abnormal_bile_salt2.73094519
7MP0005410_abnormal_fertilization2.72518183
8MP0003136_yellow_coat_color2.54138370
9MP0000372_irregular_coat_pigmentation2.30072041
10MP0009697_abnormal_copulation2.26716350
11MP0002938_white_spotting2.25767729
12MP0005646_abnormal_pituitary_gland2.24617544
13MP0005084_abnormal_gallbladder_morpholo2.19378069
14MP0001666_abnormal_nutrient_absorption1.94595939
15MP0005408_hypopigmentation1.92851642
16MP0002638_abnormal_pupillary_reflex1.91417881
17MP0008995_early_reproductive_senescence1.91272364
18MP0002160_abnormal_reproductive_system1.79488518
19MP0005187_abnormal_penis_morphology1.74534661
20MP0008058_abnormal_DNA_repair1.73040890
21MP0003186_abnormal_redox_activity1.72342224
22MP0000566_synostosis1.66161604
23MP0003868_abnormal_feces_composition1.63808325
24MP0002138_abnormal_hepatobiliary_system1.63338800
25MP0004019_abnormal_vitamin_homeostasis1.62267661
26MP0004233_abnormal_muscle_weight1.60414145
27MP0006292_abnormal_olfactory_placode1.59104338
28MP0003718_maternal_effect1.58508449
29MP0010030_abnormal_orbit_morphology1.56140040
30MP0001661_extended_life_span1.52921477
31MP0004272_abnormal_basement_membrane1.52293099
32MP0005171_absent_coat_pigmentation1.43403056
33MP0002282_abnormal_trachea_morphology1.43301246
34MP0000537_abnormal_urethra_morphology1.41997014
35MP0004147_increased_porphyrin_level1.41665911
36MP0008875_abnormal_xenobiotic_pharmacok1.39838080
37MP0008007_abnormal_cellular_replicative1.36264757
38MP0003890_abnormal_embryonic-extraembry1.34577444
39MP0003937_abnormal_limbs/digits/tail_de1.32456746
40MP0002876_abnormal_thyroid_physiology1.30172765
41MP0003252_abnormal_bile_duct1.24203197
42MP0001929_abnormal_gametogenesis1.24135823
43MP0003693_abnormal_embryo_hatching1.23987617
44MP0005332_abnormal_amino_acid1.21556247
45MP0002697_abnormal_eye_size1.18470064
46MP0004957_abnormal_blastocyst_morpholog1.17104563
47MP0003698_abnormal_male_reproductive1.12468093
48MP0001293_anophthalmia1.11650856
49MP0001986_abnormal_taste_sensitivity1.07901711
50MP0010329_abnormal_lipoprotein_level1.06580493
51MP0002102_abnormal_ear_morphology1.05356253
52MP0002928_abnormal_bile_duct1.04562101
53MP0005377_hearing/vestibular/ear_phenot1.03578461
54MP0003878_abnormal_ear_physiology1.03578461
55MP0000631_abnormal_neuroendocrine_gland1.02065602
56MP0006036_abnormal_mitochondrial_physio1.02038133
57MP0005551_abnormal_eye_electrophysiolog1.00704013
58MP0006072_abnormal_retinal_apoptosis1.00103410
59MP0005253_abnormal_eye_physiology0.98501519
60MP0002249_abnormal_larynx_morphology0.98308982
61MP0001529_abnormal_vocalization0.96969056
62MP0004133_heterotaxia0.96952374
63MP0002736_abnormal_nociception_after0.96525221
64MP0003195_calcinosis0.96523517
65MP0002090_abnormal_vision0.95553577
66MP0000653_abnormal_sex_gland0.95441414
67MP0002233_abnormal_nose_morphology0.94490156
68MP0002269_muscular_atrophy0.92635386
69MP0002210_abnormal_sex_determination0.91954103
70MP0000516_abnormal_urinary_system0.91948526
71MP0005367_renal/urinary_system_phenotyp0.91948526
72MP0001145_abnormal_male_reproductive0.91529728
73MP0005636_abnormal_mineral_homeostasis0.89336450
74MP0001764_abnormal_homeostasis0.86100969
75MP0005389_reproductive_system_phenotype0.85673993
76MP0001270_distended_abdomen0.85486430
77MP0003936_abnormal_reproductive_system0.84195389
78MP0001944_abnormal_pancreas_morphology0.83153014
79MP0003941_abnormal_skin_development0.80237137
80MP0001299_abnormal_eye_distance/0.79536645
81MP0001905_abnormal_dopamine_level0.76937517
82MP0002161_abnormal_fertility/fecundity0.76690209
83MP0009250_abnormal_appendicular_skeleto0.73326052
84MP0005391_vision/eye_phenotype0.72717079
85MP0005083_abnormal_biliary_tract0.72554727
86MP0003699_abnormal_female_reproductive0.72553223
87MP0001346_abnormal_lacrimal_gland0.72447285
88MP0001286_abnormal_eye_development0.72309006
89MP0008932_abnormal_embryonic_tissue0.71946881
90MP0009672_abnormal_birth_weight0.70695309
91MP0008872_abnormal_physiological_respon0.70103474
92MP0001881_abnormal_mammary_gland0.69547326
93MP0001919_abnormal_reproductive_system0.69247113
94MP0003123_paternal_imprinting0.68818138
95MP0005647_abnormal_sex_gland0.68332985
96MP0000383_abnormal_hair_follicle0.67798059
97MP0010368_abnormal_lymphatic_system0.67621435
98MP0001968_abnormal_touch/_nociception0.66930826
99MP0003959_abnormal_lean_body0.66106225
100MP0001324_abnormal_eye_pigmentation0.66059908

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)4.33231636
2Chronic hepatic failure (HP:0100626)4.05728806
3Intrahepatic cholestasis (HP:0001406)3.63612558
4Concave nail (HP:0001598)3.45302867
5Abnormality of methionine metabolism (HP:0010901)3.35813138
6Deep venous thrombosis (HP:0002625)3.32414258
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.31802964
8Abnormal respiratory motile cilium physiology (HP:0012261)3.25328253
9Generalized aminoaciduria (HP:0002909)3.22690574
10Abnormal ciliary motility (HP:0012262)3.13713949
11Spontaneous abortion (HP:0005268)3.04992949
12Prolonged partial thromboplastin time (HP:0003645)2.96297874
13Rhinitis (HP:0012384)2.95786013
14Reduced antithrombin III activity (HP:0001976)2.90629207
15Abnormality of alanine metabolism (HP:0010916)2.82644016
16Hyperalaninemia (HP:0003348)2.82644016
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82644016
18Abnormality of sulfur amino acid metabolism (HP:0004339)2.80127598
19Abnormality of aromatic amino acid family metabolism (HP:0004338)2.78880332
20Occipital encephalocele (HP:0002085)2.72650788
21Abnormal biliary tract physiology (HP:0012439)2.66149961
22Bile duct proliferation (HP:0001408)2.66149961
23Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62599726
24Reticulocytopenia (HP:0001896)2.58123671
25Esophageal atresia (HP:0002032)2.57346528
26Abnormal respiratory motile cilium morphology (HP:0005938)2.56264314
27Abnormal respiratory epithelium morphology (HP:0012253)2.56264314
28Hypolipoproteinemia (HP:0010981)2.50921696
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.48818392
30Glycosuria (HP:0003076)2.48584277
31Abnormality of urine glucose concentration (HP:0011016)2.48584277
32Abnormal sex determination (HP:0012244)2.47327760
33Sex reversal (HP:0012245)2.47327760
34Abnormality of pyrimidine metabolism (HP:0004353)2.45658782
35Proximal tubulopathy (HP:0000114)2.42499429
36Gastrointestinal atresia (HP:0002589)2.41402181
37Macrocytic anemia (HP:0001972)2.36661058
38Hypoglycemic coma (HP:0001325)2.33648382
39Supernumerary spleens (HP:0009799)2.32671611
40Abnormality of serum amino acid levels (HP:0003112)2.27980290
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27432697
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27432697
43Enlarged kidneys (HP:0000105)2.27407358
44Median cleft lip (HP:0000161)2.26480241
45Retinal atrophy (HP:0001105)2.25752882
46Male pseudohermaphroditism (HP:0000037)2.25343532
47Acute encephalopathy (HP:0006846)2.21032124
48Lipid accumulation in hepatocytes (HP:0006561)2.20032600
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17822358
50Fat malabsorption (HP:0002630)2.16778136
51Pancreatic fibrosis (HP:0100732)2.14971725
52Hyperglycinemia (HP:0002154)2.14357588
53Hyperbilirubinemia (HP:0002904)2.13963813
54Megaloblastic anemia (HP:0001889)2.13888206
55Birth length less than 3rd percentile (HP:0003561)2.13840662
56Aplastic anemia (HP:0001915)2.09462370
57Abnormal number of erythroid precursors (HP:0012131)2.09126978
58True hermaphroditism (HP:0010459)2.07187527
59Abnormality of cochlea (HP:0000375)2.06553952
60Intestinal atresia (HP:0011100)2.06494129
61Abnormality of the ileum (HP:0001549)2.04310376
62Meckel diverticulum (HP:0002245)2.02422952
63Hyperammonemia (HP:0001987)2.01970129
64Hyperphosphaturia (HP:0003109)2.01655825
65Partial duplication of thumb phalanx (HP:0009944)2.00430331
66Prenatal maternal abnormality (HP:0002686)1.99162833
67Duplication of thumb phalanx (HP:0009942)1.98894395
68Acanthocytosis (HP:0001927)1.97173059
69Abnormality of the common coagulation pathway (HP:0010990)1.96159324
70Acute necrotizing encephalopathy (HP:0006965)1.95461423
71Absent thumb (HP:0009777)1.95425668
72Xanthomatosis (HP:0000991)1.95204237
73Renal cortical cysts (HP:0000803)1.91965409
74Mitochondrial inheritance (HP:0001427)1.91359960
75Increased CSF lactate (HP:0002490)1.91171972
76Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90812828
77Hyperinsulinemic hypoglycemia (HP:0000825)1.86250928
78Anencephaly (HP:0002323)1.85682758
79Colon cancer (HP:0003003)1.84316762
80Absent/shortened dynein arms (HP:0200106)1.84209276
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.84209276
82Metabolic acidosis (HP:0001942)1.83591093
83Pancreatic islet-cell hyperplasia (HP:0004510)1.83359753
84Conjugated hyperbilirubinemia (HP:0002908)1.82910001
85Abnormality of cells of the erythroid lineage (HP:0012130)1.82178146
86Maternal diabetes (HP:0009800)1.81777828
87Pancreatic cysts (HP:0001737)1.79475572
88Partial duplication of the phalanx of hand (HP:0009999)1.79424252
89Triphalangeal thumb (HP:0001199)1.78031377
90Abnormal mitochondria in muscle tissue (HP:0008316)1.76494972
91Hepatic necrosis (HP:0002605)1.75011105
92Hypoglycemic seizures (HP:0002173)1.73619168
93Abnormality of the labia minora (HP:0012880)1.73607348
94Alacrima (HP:0000522)1.72827344
95Cerebral edema (HP:0002181)1.72586045
96Gonadotropin excess (HP:0000837)1.72436137
97Hypoplasia of the uterus (HP:0000013)1.72034970
98Patchy hypopigmentation of hair (HP:0011365)1.71981334
993-Methylglutaconic aciduria (HP:0003535)1.70754306
100Hepatoblastoma (HP:0002884)1.67916667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.44068642
2TSSK64.49879072
3ZAK3.57198954
4TLK13.19456001
5PDK23.08103615
6MAPK152.88977440
7FGFR22.42748378
8MARK32.38199775
9LATS12.33961255
10VRK12.22260133
11CASK2.10320004
12WEE12.07321804
13WNK31.98809269
14EIF2AK31.62169751
15BRSK21.59314588
16RPS6KA51.54677007
17TIE11.53291649
18PBK1.52763909
19NUAK11.52324428
20STK161.47850661
21VRK21.47512989
22EPHA41.43503135
23BCKDK1.42873510
24MAP2K71.41688753
25PLK31.40633177
26OBSCN1.40479615
27IRAK21.39989327
28PIK3CA1.31293203
29BUB11.27065964
30DYRK31.24766520
31MYLK1.24547484
32RPS6KB21.22505799
33CDC71.19766811
34PNCK1.18329917
35MST41.17506411
36BMPR1B1.09761722
37CCNB11.08283320
38NEK21.07891205
39STK38L1.06937777
40TAOK31.03393276
41NME21.01553528
42CSNK1G10.97422325
43CDK80.94899251
44MAP3K120.93328808
45CSNK1G30.92115250
46TTK0.90465216
47FRK0.86382553
48ACVR1B0.85568102
49MUSK0.82371889
50CSNK1A1L0.82254744
51CDK90.82073487
52CDK30.78328561
53PLK10.77646998
54CSNK1G20.77641919
55RPS6KB10.75640359
56KDR0.73860050
57TAF10.73802923
58MAP3K40.73326994
59SRPK10.73020938
60ATR0.70478296
61INSRR0.69707510
62AURKB0.65627988
63AKT20.64303614
64MELK0.60813429
65PIK3CG0.60346887
66ATM0.59969549
67CSNK2A20.58390133
68TGFBR10.58342541
69CSNK1A10.57808505
70CSNK2A10.57231304
71SCYL20.54761242
72MAPKAPK30.52726584
73GRK10.50588153
74CSNK1E0.50041426
75BRSK10.47094846
76PRKACB0.46888971
77DAPK30.46400916
78TNIK0.44797814
79PRKG10.42237866
80MAP2K20.41498206
81AURKA0.40965759
82NLK0.38768865
83PRKCG0.38756085
84EIF2AK10.36795719
85NEK10.35280214
86NTRK30.34828362
87PRKCE0.34513669
88PRKCQ0.34175679
89STK30.32151858
90PAK40.31069990
91CHEK20.30896002
92CAMK2D0.30738549
93PASK0.30156921
94CDK70.29690478
95TRIM280.29550025
96PLK40.28361414
97MAP2K10.27545419
98MAP3K30.27388162
99CAMK2G0.27336837
100CHEK10.26098423

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.65656271
2Steroid hormone biosynthesis_Homo sapiens_hsa001402.80276613
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71964484
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.47757282
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44691002
6Ribosome_Homo sapiens_hsa030102.33992075
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23693655
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22353072
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.17088150
10* Arginine biosynthesis_Homo sapiens_hsa002202.16553641
11Chemical carcinogenesis_Homo sapiens_hsa052042.16533299
12Proteasome_Homo sapiens_hsa030502.16289858
13Butanoate metabolism_Homo sapiens_hsa006502.13258351
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.05212979
15One carbon pool by folate_Homo sapiens_hsa006701.99215583
16Retinol metabolism_Homo sapiens_hsa008301.95914960
17Oxidative phosphorylation_Homo sapiens_hsa001901.94177195
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90903049
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.87085353
20Glutathione metabolism_Homo sapiens_hsa004801.83338800
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.78199131
22Propanoate metabolism_Homo sapiens_hsa006401.76393226
23Peroxisome_Homo sapiens_hsa041461.70428682
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69742275
25Parkinsons disease_Homo sapiens_hsa050121.69334855
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69251148
27Sulfur metabolism_Homo sapiens_hsa009201.63796821
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.60911223
29Complement and coagulation cascades_Homo sapiens_hsa046101.55854970
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48728318
31Pyruvate metabolism_Homo sapiens_hsa006201.47925383
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46704732
33Fat digestion and absorption_Homo sapiens_hsa049751.33691449
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33334875
35Sulfur relay system_Homo sapiens_hsa041221.31393337
36Systemic lupus erythematosus_Homo sapiens_hsa053221.26433046
37Selenocompound metabolism_Homo sapiens_hsa004501.24837347
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24342034
39RNA polymerase_Homo sapiens_hsa030201.20565488
40Homologous recombination_Homo sapiens_hsa034401.19727527
41Tyrosine metabolism_Homo sapiens_hsa003501.18086758
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15425429
43Fatty acid elongation_Homo sapiens_hsa000621.14614394
44Huntingtons disease_Homo sapiens_hsa050161.14183009
45Vitamin digestion and absorption_Homo sapiens_hsa049771.13220184
46Basal transcription factors_Homo sapiens_hsa030221.12861287
47Phenylalanine metabolism_Homo sapiens_hsa003601.10778860
48* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10383764
49Biosynthesis of amino acids_Homo sapiens_hsa012301.05775504
50Tryptophan metabolism_Homo sapiens_hsa003801.04711930
51Fatty acid degradation_Homo sapiens_hsa000711.04557288
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04016200
53* Carbon metabolism_Homo sapiens_hsa012001.00953890
54Starch and sucrose metabolism_Homo sapiens_hsa005000.99694326
55Fanconi anemia pathway_Homo sapiens_hsa034600.99365617
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96362494
57Hedgehog signaling pathway_Homo sapiens_hsa043400.95482098
58PPAR signaling pathway_Homo sapiens_hsa033200.94467402
59Mismatch repair_Homo sapiens_hsa034300.93735952
60Alzheimers disease_Homo sapiens_hsa050100.92824017
61Spliceosome_Homo sapiens_hsa030400.91895740
62Fatty acid metabolism_Homo sapiens_hsa012120.89220389
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88228945
64Arginine and proline metabolism_Homo sapiens_hsa003300.87101597
65* Metabolic pathways_Homo sapiens_hsa011000.82626866
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78178931
67Protein export_Homo sapiens_hsa030600.75508351
68RNA transport_Homo sapiens_hsa030130.74255116
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71269232
70Purine metabolism_Homo sapiens_hsa002300.71070912
71ABC transporters_Homo sapiens_hsa020100.69100699
72Caffeine metabolism_Homo sapiens_hsa002320.68714224
73Steroid biosynthesis_Homo sapiens_hsa001000.67881129
74Phototransduction_Homo sapiens_hsa047440.65836505
75beta-Alanine metabolism_Homo sapiens_hsa004100.65005760
76* Nitrogen metabolism_Homo sapiens_hsa009100.63754074
77Alcoholism_Homo sapiens_hsa050340.62463916
78Linoleic acid metabolism_Homo sapiens_hsa005910.61980908
79Folate biosynthesis_Homo sapiens_hsa007900.57545514
80Bile secretion_Homo sapiens_hsa049760.57086206
81N-Glycan biosynthesis_Homo sapiens_hsa005100.55017753
82Pentose phosphate pathway_Homo sapiens_hsa000300.50156710
83Pyrimidine metabolism_Homo sapiens_hsa002400.48999286
84* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47861870
85RNA degradation_Homo sapiens_hsa030180.47071996
86TGF-beta signaling pathway_Homo sapiens_hsa043500.46013309
87Olfactory transduction_Homo sapiens_hsa047400.45529688
88Cardiac muscle contraction_Homo sapiens_hsa042600.41941136
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41727095
90Nucleotide excision repair_Homo sapiens_hsa034200.38982191
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36486289
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35050983
93DNA replication_Homo sapiens_hsa030300.34437702
94Galactose metabolism_Homo sapiens_hsa000520.32891518
95Arachidonic acid metabolism_Homo sapiens_hsa005900.31025848
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30344895
97mRNA surveillance pathway_Homo sapiens_hsa030150.28252455
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28027005
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21763396
100Oocyte meiosis_Homo sapiens_hsa041140.21559072

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