GLUL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.32494349
2locomotory exploration behavior (GO:0035641)4.61406381
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.50840846
4L-amino acid import (GO:0043092)4.50102950
5cellular potassium ion homeostasis (GO:0030007)4.33048700
6positive regulation of cellular amide metabolic process (GO:0034250)4.26452779
7sodium ion export (GO:0071436)4.25350903
8cellular response to thyroid hormone stimulus (GO:0097067)4.18380157
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.16041275
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.11207533
11glutamate secretion (GO:0014047)4.09845439
12gamma-aminobutyric acid transport (GO:0015812)3.94269819
13synaptic vesicle exocytosis (GO:0016079)3.87480700
14negative regulation of erythrocyte differentiation (GO:0045647)3.81502200
15axon ensheathment in central nervous system (GO:0032291)3.80434590
16central nervous system myelination (GO:0022010)3.80434590
17regulation of beta-amyloid formation (GO:1902003)3.80069335
18glycine transport (GO:0015816)3.70377489
19potassium ion import (GO:0010107)3.68571013
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.65827005
21cerebellar granule cell differentiation (GO:0021707)3.58742984
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57581828
23regulation of synaptic vesicle exocytosis (GO:2000300)3.57185640
24vocalization behavior (GO:0071625)3.57023374
25regulation of neuronal synaptic plasticity (GO:0048168)3.54146432
26neurotransmitter secretion (GO:0007269)3.54009528
27neuronal action potential propagation (GO:0019227)3.46971010
28amino acid import (GO:0043090)3.44319792
29layer formation in cerebral cortex (GO:0021819)3.39740889
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.39610609
31regulation of glutamate receptor signaling pathway (GO:1900449)3.31519715
32regulation of amyloid precursor protein catabolic process (GO:1902991)3.30555777
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28944863
34regulation of synapse structural plasticity (GO:0051823)3.28217924
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24391406
36regulation of synaptic vesicle transport (GO:1902803)3.21358604
37neurotransmitter-gated ion channel clustering (GO:0072578)3.20020635
38potassium ion homeostasis (GO:0055075)3.19984227
39cellular sodium ion homeostasis (GO:0006883)3.17442691
40negative regulation of inclusion body assembly (GO:0090084)3.08655363
41negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.07637487
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.05734348
43response to thyroid hormone (GO:0097066)3.05419989
44positive regulation of macrophage cytokine production (GO:0060907)3.01977845
45dendritic spine morphogenesis (GO:0060997)3.01169168
46cell communication by electrical coupling (GO:0010644)2.99680853
47exploration behavior (GO:0035640)2.99391796
48neuromuscular process controlling balance (GO:0050885)2.99150987
49neuromuscular process controlling posture (GO:0050884)2.99149617
50activation of protein kinase A activity (GO:0034199)2.97085746
51C4-dicarboxylate transport (GO:0015740)2.96778391
52long-term memory (GO:0007616)2.96241713
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95826223
54detection of molecule of bacterial origin (GO:0032490)2.92441354
55regulation of ARF protein signal transduction (GO:0032012)2.90146782
56* neurotransmitter transport (GO:0006836)2.89150809
57negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87344336
58regulation of cellular amide metabolic process (GO:0034248)2.86982298
59adenosine receptor signaling pathway (GO:0001973)2.84049436
60protein localization to synapse (GO:0035418)2.83442931
61alanine transport (GO:0032328)2.80920511
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79516670
63response to auditory stimulus (GO:0010996)2.78577651
64alpha-linolenic acid metabolic process (GO:0036109)2.77090971
65* regulation of neurotransmitter levels (GO:0001505)2.76517779
66regulation of inclusion body assembly (GO:0090083)2.74196757
67proline transport (GO:0015824)2.73730868
68synaptic transmission, glutamatergic (GO:0035249)2.70823839
69acidic amino acid transport (GO:0015800)2.69403998
70dicarboxylic acid biosynthetic process (GO:0043650)2.69179045
71one-carbon compound transport (GO:0019755)2.67458148
72L-glutamate transport (GO:0015813)2.66774817
73regulation of synaptic plasticity (GO:0048167)2.66361259
74positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64163329
75positive regulation of membrane potential (GO:0045838)2.63588191
76nerve growth factor signaling pathway (GO:0038180)2.63020760
77auditory behavior (GO:0031223)2.62030719
78epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62004819
79regulation of excitatory postsynaptic membrane potential (GO:0060079)2.61808898
80glutamate receptor signaling pathway (GO:0007215)2.61382042
81regulation of myeloid leukocyte mediated immunity (GO:0002886)2.60092227
82regulation of dendritic spine morphogenesis (GO:0061001)2.58915205
83L-phenylalanine catabolic process (GO:0006559)2.58810888
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.58810888
85dendrite morphogenesis (GO:0048813)2.57328422
86gas transport (GO:0015669)2.57121618
87neuron-neuron synaptic transmission (GO:0007270)2.56039037
88macrophage activation involved in immune response (GO:0002281)2.56034224
89regulation of clathrin-mediated endocytosis (GO:2000369)2.53047069
90macrophage activation (GO:0042116)2.52072671
91positive regulation of gamma-delta T cell activation (GO:0046645)2.51637618
92regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51448824
93prepulse inhibition (GO:0060134)2.51112300
94regulation of macrophage cytokine production (GO:0010935)2.50976321
95neuronal ion channel clustering (GO:0045161)2.50792449
96response to peptidoglycan (GO:0032494)2.50309516
97positive regulation of dendritic spine development (GO:0060999)2.49528028
98positive regulation of Rap GTPase activity (GO:0032854)2.49399080
99regulation of T-helper 2 cell differentiation (GO:0045628)2.49285281
100regulation of regulated secretory pathway (GO:1903305)2.49197481
101actin filament polymerization (GO:0030041)2.48609067
102transmission of nerve impulse (GO:0019226)2.48289607
103membrane hyperpolarization (GO:0060081)2.47528183
104regulation of postsynaptic membrane potential (GO:0060078)2.46988705
105* neurotransmitter uptake (GO:0001504)2.45506941
106import into cell (GO:0098657)2.45040755
107positive regulation of synapse maturation (GO:0090129)2.44783700
108negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.44593198
109regulation of leukocyte degranulation (GO:0043300)2.43769187
110adult walking behavior (GO:0007628)2.43700630
111positive regulation of mast cell activation involved in immune response (GO:0033008)2.43556730
112positive regulation of mast cell degranulation (GO:0043306)2.43556730
113cerebellar Purkinje cell differentiation (GO:0021702)2.43379341
114cell volume homeostasis (GO:0006884)2.43306749
115regulation of hydrogen peroxide-induced cell death (GO:1903205)2.42924346
116microglial cell activation (GO:0001774)2.42869001
117long-term synaptic potentiation (GO:0060291)2.42503225
118positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42435286
119response to manganese ion (GO:0010042)2.41609433
120myelin maintenance (GO:0043217)2.41346368
121cellular extravasation (GO:0045123)2.40523818
122regulation of mast cell degranulation (GO:0043304)2.39507556
123regulation of voltage-gated calcium channel activity (GO:1901385)2.39062278
124negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38273636
125positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.37662131
126erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.37544690
127L-phenylalanine metabolic process (GO:0006558)2.37544690
128membrane repolarization (GO:0086009)2.37219474
129regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.37182119
130regulation of macrophage chemotaxis (GO:0010758)2.36636405
131regulation of ARF GTPase activity (GO:0032312)2.36428419
132positive regulation of potassium ion transmembrane transport (GO:1901381)2.35557696
133positive regulation of cholesterol efflux (GO:0010875)2.35392846
134positive regulation of potassium ion transport (GO:0043268)2.35326477
135regulation of neurotransmitter secretion (GO:0046928)2.35138508
136neuron cell-cell adhesion (GO:0007158)2.33247791
137cerebellar Purkinje cell layer development (GO:0021680)2.32838098
138apoptotic cell clearance (GO:0043277)2.32304154
139neuromuscular process (GO:0050905)2.32241553
140response to methylmercury (GO:0051597)2.32164385
141modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30114796
142modulation by symbiont of host immune response (GO:0052553)2.30114796
143CDP-diacylglycerol biosynthetic process (GO:0016024)2.29322396
144mating behavior (GO:0007617)2.28827898
145vesicle transport along microtubule (GO:0047496)2.28330355
146regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.28190889
147* positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.28040181
148regulation of neurotransmitter transport (GO:0051588)2.27466180
149negative regulation of cytosolic calcium ion concentration (GO:0051481)2.27320583
150peptidyl-tyrosine autophosphorylation (GO:0038083)2.27064009
151cytoskeletal anchoring at plasma membrane (GO:0007016)2.25986230
152regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.24882042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.89258099
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.88018053
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59932222
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52551950
5DROSHA_22980978_ChIP-Seq_HELA_Human2.43340652
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37707934
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37707934
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.32532661
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28859339
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27825907
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24189108
12* GATA1_19941826_ChIP-Seq_K562_Human2.17273755
13GATA1_22025678_ChIP-Seq_K562_Human2.14739310
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14118451
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12528932
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10996338
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10465624
18GBX2_23144817_ChIP-Seq_PC3_Human2.10428560
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10420073
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08542842
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07801554
22SCL_19346495_ChIP-Seq_HPC-7_Human2.05589357
23REST_21632747_ChIP-Seq_MESCs_Mouse1.98533478
24SPI1_23127762_ChIP-Seq_K562_Human1.93403603
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91419609
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.85511835
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.83402820
28GATA1_19941827_ChIP-Seq_MEL_Mouse1.82378729
29* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81813587
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.78613132
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78321349
32LXR_22292898_ChIP-Seq_THP-1_Human1.75347465
33AR_21572438_ChIP-Seq_LNCaP_Human1.74487782
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72997124
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.72790051
36* EZH2_27304074_Chip-Seq_ESCs_Mouse1.72733995
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71028217
38* IRF8_27001747_Chip-Seq_BMDM_Mouse1.70656102
39* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70090276
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.69163232
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62765722
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58948312
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.57189264
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54313430
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.51799924
46* GATA2_19941826_ChIP-Seq_K562_Human1.48293645
47* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48155115
48CLOCK_20551151_ChIP-Seq_293T_Human1.45392945
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.39945532
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39133921
51* KDM2B_26808549_Chip-Seq_DND41_Human1.39001804
52* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38482289
53TCF7_22412390_ChIP-Seq_EML_Mouse1.36888174
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33661729
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33424083
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32776160
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31584975
58VDR_24763502_ChIP-Seq_THP-1_Human1.31271809
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30697751
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30689989
61VDR_24787735_ChIP-Seq_THP-1_Human1.29739054
62* KDM2B_26808549_Chip-Seq_K562_Human1.29192688
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24074246
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23634443
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22134205
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21761552
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.21480174
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20703799
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.17660156
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17562376
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17323693
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12481382
73* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11653774
74* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11230996
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11188649
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.10775837
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10633930
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10256167
79* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10246258
80SMAD4_21799915_ChIP-Seq_A2780_Human1.09766634
81FOXA2_19822575_ChIP-Seq_HepG2_Human1.09357652
82SMC4_20622854_ChIP-Seq_HELA_Human1.09297932
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08692448
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08599951
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06780524
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06455095
87VDR_21846776_ChIP-Seq_THP-1_Human1.05939245
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.05401221
89* AR_19668381_ChIP-Seq_PC3_Human1.04587671
90* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04311531
91RXR_22108803_ChIP-Seq_LS180_Human1.03685644
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02797444
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02419573
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02119039
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02096903
96* TBX20_22328084_ChIP-Seq_HEART_Mouse1.01515317
97* TBX20_22080862_ChIP-Seq_HEART_Mouse1.01515317
98* KDM2B_26808549_Chip-Seq_JURKAT_Human1.00874054
99* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00626649
100KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00309150
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00174467
102ESR1_20079471_ChIP-ChIP_T-47D_Human0.99008620
103EGR1_19374776_ChIP-ChIP_THP-1_Human0.98837091
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.97933859
105* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97778027
106AHR_22903824_ChIP-Seq_MCF-7_Human0.96843038
107PIAS1_25552417_ChIP-Seq_VCAP_Human0.96233180
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96012755
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96009971
110* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96007261
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95416047
112RUNX1_22412390_ChIP-Seq_EML_Mouse0.95191953
113* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95139546
114BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94540387
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94418710
116* RUNX_20019798_ChIP-Seq_JUKART_Human0.94021719
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93859291
118STAT3_23295773_ChIP-Seq_U87_Human0.93809340
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93435228
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92887792
121EP300_21415370_ChIP-Seq_HL-1_Mouse0.91568806
122* RING1B_27294783_Chip-Seq_NPCs_Mouse0.91068532
123* SMAD3_21741376_ChIP-Seq_HESCs_Human0.90959435
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90759620
125AR_25329375_ChIP-Seq_VCAP_Human0.89924380
126* EGR1_19032775_ChIP-ChIP_M12_Human0.89763068
127CTCF_27219007_Chip-Seq_Bcells_Human0.89349599
128KLF4_19829295_ChIP-Seq_ESCs_Human0.89096001
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.88523335
130IRF8_21731497_ChIP-ChIP_J774_Mouse0.88301103
131OCT4_19829295_ChIP-Seq_ESCs_Human0.88262052
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87875647
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87662666
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87642553
135EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87197971
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86888625
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85637693
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85043257
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83439603
140* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83344966
141* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82011690
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81807936
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81664332
144SMAD_19615063_ChIP-ChIP_OVARY_Human0.81219201
145* TET1_21490601_ChIP-Seq_MESCs_Mouse0.80924470
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79898455
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79517216
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79517216
149TP53_16413492_ChIP-PET_HCT116_Human0.79025598
150CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78687368
151VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77279020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.55592288
2MP0003635_abnormal_synaptic_transmissio3.35772374
3MP0004270_analgesia3.35728023
4MP0003880_abnormal_central_pattern3.31022093
5MP0003303_peritoneal_inflammation2.83535802
6MP0002064_seizures2.80583682
7MP0009745_abnormal_behavioral_response2.70133383
8MP0002822_catalepsy2.61594931
9MP0005423_abnormal_somatic_nervous2.59799189
10MP0003690_abnormal_glial_cell2.58223206
11MP0002063_abnormal_learning/memory/cond2.55684641
12MP0001486_abnormal_startle_reflex2.54982803
13MP0009046_muscle_twitch2.42799125
14MP0003329_amyloid_beta_deposits2.39260835
15MP0003724_increased_susceptibility_to2.35312186
16MP0002272_abnormal_nervous_system2.32620233
17MP0004885_abnormal_endolymph2.31577777
18MP0004147_increased_porphyrin_level2.20047767
19MP0002139_abnormal_hepatobiliary_system2.11170549
20MP0002572_abnormal_emotion/affect_behav2.07754863
21MP0009780_abnormal_chondrocyte_physiolo2.03685453
22MP0001501_abnormal_sleep_pattern2.00512901
23MP0008569_lethality_at_weaning1.96485060
24MP0002909_abnormal_adrenal_gland1.94031500
25MP0002734_abnormal_mechanical_nocicepti1.93113357
26MP0000920_abnormal_myelination1.88818803
27MP0003633_abnormal_nervous_system1.86063579
28MP0001968_abnormal_touch/_nociception1.79655956
29MP0009278_abnormal_bone_marrow1.75743841
30MP0004858_abnormal_nervous_system1.70161549
31MP0003656_abnormal_erythrocyte_physiolo1.70038552
32MP0005360_urolithiasis1.68696996
33MP0004130_abnormal_muscle_cell1.63920745
34MP0005167_abnormal_blood-brain_barrier1.63738699
35MP0003075_altered_response_to1.63678945
36MP0005085_abnormal_gallbladder_physiolo1.61330296
37MP0003436_decreased_susceptibility_to1.59769796
38MP0004043_abnormal_pH_regulation1.59082324
39MP0002419_abnormal_innate_immunity1.57479216
40MP0005365_abnormal_bile_salt1.55328548
41MP0005397_hematopoietic_system_phenotyp1.54409903
42MP0001545_abnormal_hematopoietic_system1.54409903
43MP0001440_abnormal_grooming_behavior1.52251035
44MP0005646_abnormal_pituitary_gland1.50868030
45MP0005551_abnormal_eye_electrophysiolog1.49265343
46MP0008260_abnormal_autophagy1.48838294
47MP0010329_abnormal_lipoprotein_level1.48793995
48MP0003631_nervous_system_phenotype1.46134672
49MP0000604_amyloidosis1.44234083
50MP0005464_abnormal_platelet_physiology1.43436441
51MP0002067_abnormal_sensory_capabilities1.42530595
52MP0001970_abnormal_pain_threshold1.39426551
53MP0006082_CNS_inflammation1.37610632
54MP0002090_abnormal_vision1.37021469
55MP0000343_altered_response_to1.36164700
56MP0002733_abnormal_thermal_nociception1.35371814
57MP0008875_abnormal_xenobiotic_pharmacok1.34117591
58MP0003634_abnormal_glial_cell1.32573312
59MP0005535_abnormal_body_temperature1.29074235
60MP0003828_pulmonary_edema1.28553177
61MP0002229_neurodegeneration1.26188171
62MP0000955_abnormal_spinal_cord1.24752128
63MP0005386_behavior/neurological_phenoty1.22481032
64MP0004924_abnormal_behavior1.22481032
65MP0002066_abnormal_motor_capabilities/c1.22376814
66MP0004811_abnormal_neuron_physiology1.21589639
67MP0003300_gastrointestinal_ulcer1.20749488
68MP0002557_abnormal_social/conspecific_i1.19732244
69MP0002132_abnormal_respiratory_system1.19085644
70MP0001853_heart_inflammation1.18796762
71MP0000013_abnormal_adipose_tissue1.15017822
72MP0002118_abnormal_lipid_homeostasis1.14706541
73MP0004142_abnormal_muscle_tone1.14186808
74MP0001502_abnormal_circadian_rhythm1.13669410
75MP0002882_abnormal_neuron_morphology1.13484073
76MP0002736_abnormal_nociception_after1.13458336
77MP0000778_abnormal_nervous_system1.07732857
78MP0008961_abnormal_basal_metabolism1.07358048
79MP0005025_abnormal_response_to1.07289192
80MP0008874_decreased_physiological_sensi1.06436552
81MP0009840_abnormal_foam_cell1.04797423
82MP0003632_abnormal_nervous_system1.04713183
83MP0001177_atelectasis1.04536727
84MP0002998_abnormal_bone_remodeling1.03881557
85MP0001533_abnormal_skeleton_physiology1.03730278
86MP0002133_abnormal_respiratory_system1.03314018
87MP0005388_respiratory_system_phenotype1.03314018
88MP0004883_abnormal_blood_vessel1.03144976
89MP0003879_abnormal_hair_cell1.02808883
90* MP0005332_abnormal_amino_acid1.01644514
91MP0003191_abnormal_cellular_cholesterol1.00084324
92MP0008872_abnormal_physiological_respon0.98881163
93MP0005584_abnormal_enzyme/coenzyme_acti0.98414097
94MP0003011_delayed_dark_adaptation0.95310556
95MP0003195_calcinosis0.95141127
96MP0005670_abnormal_white_adipose0.94432691
97MP0005666_abnormal_adipose_tissue0.93162357
98MP0003252_abnormal_bile_duct0.92722936
99MP0000751_myopathy0.92369198
100MP0004947_skin_inflammation0.91716298
101MP0001851_eye_inflammation0.91626976
102MP0008004_abnormal_stomach_pH0.90448255
103MP0000747_muscle_weakness0.89584030
104MP0004145_abnormal_muscle_electrophysio0.87078702
105MP0004185_abnormal_adipocyte_glucose0.86941308
106MP0002148_abnormal_hypersensitivity_rea0.86318598
107MP0000681_abnormal_thyroid_gland0.86267069
108MP0005451_abnormal_body_composition0.86066119
109MP0005377_hearing/vestibular/ear_phenot0.85978681
110MP0003878_abnormal_ear_physiology0.85978681
111MP0009764_decreased_sensitivity_to0.84903216
112MP0005000_abnormal_immune_tolerance0.83763221
113* MP0002069_abnormal_eating/drinking_beha0.82463996
114MP0005164_abnormal_response_to0.81586557
115MP0005375_adipose_tissue_phenotype0.81265590
116MP0005058_abnormal_lysosome_morphology0.81065767
117MP0003283_abnormal_digestive_organ0.81010794
118MP0005165_increased_susceptibility_to0.80898111
119MP0003172_abnormal_lysosome_physiology0.80615208
120MP0004085_abnormal_heartbeat0.79662756
121* MP0002152_abnormal_brain_morphology0.77553934
122MP0004215_abnormal_myocardial_fiber0.76820926
123MP0000465_gastrointestinal_hemorrhage0.76196639
124MP0002735_abnormal_chemical_nociception0.76052506
125MP0002184_abnormal_innervation0.75953435
126MP0000003_abnormal_adipose_tissue0.75873072
127MP0001485_abnormal_pinna_reflex0.75269897
128MP0003453_abnormal_keratinocyte_physiol0.74340419
129MP0001984_abnormal_olfaction0.74219676
130MP0001905_abnormal_dopamine_level0.73780835
131MP0002837_dystrophic_cardiac_calcinosis0.73309854
132MP0005253_abnormal_eye_physiology0.72496704
133MP0004510_myositis0.71864857
134MP0005166_decreased_susceptibility_to0.71226174
135MP0003137_abnormal_impulse_conducting0.70302034
136MP0002971_abnormal_brown_adipose0.68834987
137MP0004742_abnormal_vestibular_system0.67818025
138MP0005645_abnormal_hypothalamus_physiol0.66687266
139MP0001790_abnormal_immune_system0.65996450
140MP0005387_immune_system_phenotype0.65996450
141MP0010234_abnormal_vibrissa_follicle0.65146117
142MP0001963_abnormal_hearing_physiology0.64057288
143MP0003705_abnormal_hypodermis_morpholog0.63825562
144MP0005409_darkened_coat_color0.63499822
145MP0009115_abnormal_fat_cell0.63158863

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.68610498
2Focal motor seizures (HP:0011153)5.05041521
3Action tremor (HP:0002345)4.03519948
4Focal seizures (HP:0007359)3.86442501
5Neurofibrillary tangles (HP:0002185)3.72972743
6Systemic lupus erythematosus (HP:0002725)3.62428468
7Visual hallucinations (HP:0002367)3.57178659
8Supranuclear gaze palsy (HP:0000605)3.51570800
9Intention tremor (HP:0002080)3.46955399
10Ankle clonus (HP:0011448)3.38423738
11Postural instability (HP:0002172)3.31452990
12Eczematoid dermatitis (HP:0000976)3.26789304
13Hemiplegia (HP:0002301)3.22030180
14Increased cerebral lipofuscin (HP:0011813)3.13551680
15Cerebral inclusion bodies (HP:0100314)3.07793095
16Dysdiadochokinesis (HP:0002075)3.06972088
17Dysmetria (HP:0001310)3.06502334
18Megalencephaly (HP:0001355)3.06028582
19Recurrent abscess formation (HP:0002722)3.05947879
20Generalized tonic-clonic seizures (HP:0002069)3.03960126
21Abnormality of glycolipid metabolism (HP:0010969)3.03956095
22Abnormality of liposaccharide metabolism (HP:0010968)3.03956095
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.03956095
24Recurrent bacterial skin infections (HP:0005406)2.99772308
25Glomerulonephritis (HP:0000099)2.88506206
26Depression (HP:0000716)2.85092523
27Recurrent gram-negative bacterial infections (HP:0005420)2.83298699
28Progressive cerebellar ataxia (HP:0002073)2.82091561
29Obstructive sleep apnea (HP:0002870)2.77839012
30Epileptic encephalopathy (HP:0200134)2.77592155
31Abnormal eating behavior (HP:0100738)2.71399389
32Anxiety (HP:0000739)2.70718179
33Hemiparesis (HP:0001269)2.70248054
34Torticollis (HP:0000473)2.69715334
35Amyloidosis (HP:0011034)2.67893690
36Impaired vibration sensation in the lower limbs (HP:0002166)2.63681727
37Abnormality of macrophages (HP:0004311)2.63208537
38Impaired social interactions (HP:0000735)2.62822061
39Abnormal social behavior (HP:0012433)2.62822061
40Status epilepticus (HP:0002133)2.61559383
41Poor eye contact (HP:0000817)2.57125663
42Absence seizures (HP:0002121)2.53368418
43Diplopia (HP:0000651)2.50621489
44Abnormality of binocular vision (HP:0011514)2.50621489
45Spastic gait (HP:0002064)2.49897021
46Aplasia of the phalanges of the hand (HP:0009802)2.49628541
47Aplasia involving bones of the extremities (HP:0009825)2.49628541
48Aplasia involving bones of the upper limbs (HP:0009823)2.49628541
49Scanning speech (HP:0002168)2.49080093
50Urinary bladder sphincter dysfunction (HP:0002839)2.48615246
51Complement deficiency (HP:0004431)2.44464885
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44086017
53Focal dystonia (HP:0004373)2.43544317
54* Abnormality of the periventricular white matter (HP:0002518)2.42722158
55Urinary urgency (HP:0000012)2.42438654
56Hyperlipoproteinemia (HP:0010980)2.42089597
57Dialeptic seizures (HP:0011146)2.39398771
58Slow saccadic eye movements (HP:0000514)2.38925431
59Increased circulating renin level (HP:0000848)2.36177796
60Truncal ataxia (HP:0002078)2.32723108
61Deep venous thrombosis (HP:0002625)2.32499964
62Apathy (HP:0000741)2.30877726
63Papilledema (HP:0001085)2.30185019
64Xanthomatosis (HP:0000991)2.29512289
65Atonic seizures (HP:0010819)2.29427699
66Ventricular fibrillation (HP:0001663)2.29267993
67Bowel incontinence (HP:0002607)2.29084637
68Onion bulb formation (HP:0003383)2.28936786
69Delusions (HP:0000746)2.28220192
70Craniofacial dystonia (HP:0012179)2.27941687
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.27790849
72Abnormal large intestine physiology (HP:0012700)2.26420033
73Abnormality of glycine metabolism (HP:0010895)2.25181358
74Abnormality of serine family amino acid metabolism (HP:0010894)2.25181358
75Bundle branch block (HP:0011710)2.25121332
76Mutism (HP:0002300)2.24018618
77Peripheral hypomyelination (HP:0007182)2.22450203
78Tetraplegia (HP:0002445)2.21217640
79Purpura (HP:0000979)2.21205572
80Interstitial pulmonary disease (HP:0006530)2.18781386
81Gaze-evoked nystagmus (HP:0000640)2.17063255
82Abnormality of the lower motor neuron (HP:0002366)2.15592965
83Clonus (HP:0002169)2.15329188
84Broad-based gait (HP:0002136)2.14972493
85Confusion (HP:0001289)2.14677819
86Memory impairment (HP:0002354)2.14044880
87Dementia (HP:0000726)2.13860449
88Rigidity (HP:0002063)2.13131729
89Bradykinesia (HP:0002067)2.13097049
90Diminished motivation (HP:0000745)2.12847600
91Termporal pattern (HP:0011008)2.11493628
92Insidious onset (HP:0003587)2.11493628
93Polycythemia (HP:0001901)2.10967772
94Spastic tetraparesis (HP:0001285)2.10735642
95Febrile seizures (HP:0002373)2.10017473
96Lower limb muscle weakness (HP:0007340)2.09251560
97Pheochromocytoma (HP:0002666)2.08904379
98Disinhibition (HP:0000734)2.08455126
99Neuronal loss in central nervous system (HP:0002529)2.06468145
100Hyperglycinuria (HP:0003108)2.04860521
101Ketosis (HP:0001946)2.04839641
102Segmental peripheral demyelination/remyelination (HP:0003481)2.03955265
103Muscle fiber splitting (HP:0003555)2.03479053
104Dysmetric saccades (HP:0000641)2.03425570
105Hyperventilation (HP:0002883)2.02889669
106Retinal atrophy (HP:0001105)2.02548980
107Cellulitis (HP:0100658)2.01943226
108Abnormality of the corticospinal tract (HP:0002492)2.01915718
109Metabolic alkalosis (HP:0200114)2.01399561
110Myositis (HP:0100614)2.01213618
111Intrahepatic cholestasis (HP:0001406)1.98836715
112Clumsiness (HP:0002312)1.97624861
113Orchitis (HP:0100796)1.97407177
114Abnormality of saccadic eye movements (HP:0000570)1.97278523
115Impaired vibratory sensation (HP:0002495)1.97061675
116Cholecystitis (HP:0001082)1.96550604
117Abnormal gallbladder physiology (HP:0012438)1.96550604
118Abnormality of complement system (HP:0005339)1.95890832
119Vertigo (HP:0002321)1.95459591
120Annular pancreas (HP:0001734)1.95177579
121Dysostosis multiplex (HP:0000943)1.95084315
122Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94319578
123Decreased motor nerve conduction velocity (HP:0003431)1.93318981
124Turricephaly (HP:0000262)1.92949299
125Genetic anticipation (HP:0003743)1.92782236
126Hyperglycinemia (HP:0002154)1.92422454
127Lower limb asymmetry (HP:0100559)1.92243115
128Choreoathetosis (HP:0001266)1.92116419
129Loss of speech (HP:0002371)1.91234522
130Ketoacidosis (HP:0001993)1.90795712
131Retrobulbar optic neuritis (HP:0100654)1.90024738
132Optic neuritis (HP:0100653)1.90024738
133Myocardial infarction (HP:0001658)1.89625396
134Exercise-induced myalgia (HP:0003738)1.89593536
135Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88533287
136Personality changes (HP:0000751)1.87532697
137Increased CSF protein (HP:0002922)1.86589701
138Insomnia (HP:0100785)1.86547128
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86234042
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.86234042
141Postural tremor (HP:0002174)1.85741769
142Mediastinal lymphadenopathy (HP:0100721)1.85229911
143Axonal loss (HP:0003447)1.84494480
144Abnormality of the Achilles tendon (HP:0005109)1.83865312
145Generalized myoclonic seizures (HP:0002123)1.83578972
146Dynein arm defect of respiratory motile cilia (HP:0012255)1.82975109
147Absent/shortened dynein arms (HP:0200106)1.82975109
148Foot dorsiflexor weakness (HP:0009027)1.82167602
149Rapidly progressive (HP:0003678)1.82156844
150Central scotoma (HP:0000603)1.81867803
151Global brain atrophy (HP:0002283)1.80114607
152Gait ataxia (HP:0002066)1.79785132
153Gingivitis (HP:0000230)1.79471321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.88658852
2PRKD33.14457315
3NTRK33.04876090
4MAP3K93.00416671
5DAPK22.48631573
6PAK62.27322148
7KSR22.21568215
8MAP3K42.08142734
9NTRK12.04809004
10CAMKK12.04487203
11NTRK21.99838299
12MINK11.86482792
13PINK11.81138080
14TRIB31.79362202
15BLK1.71897903
16MATK1.68878553
17MAP2K41.67258236
18SGK2231.66913181
19SGK4941.66913181
20LMTK21.58984380
21CAMK1G1.58615502
22STK381.55688536
23BMPR21.55021811
24JAK21.54307634
25OXSR11.54085136
26MARK11.53080841
27FGFR21.47037890
28TYRO31.46606002
29PHKG21.44670903
30PHKG11.44670903
31STK391.43298202
32MAP3K21.41573157
33CDK51.40716650
34TYK21.29012539
35PRKCH1.26115143
36RIPK11.22060183
37MAPK151.20912888
38MAP2K71.19659876
39SGK31.17409345
40PDPK11.16798046
41CAMK1D1.13533242
42RAF11.04660678
43PDK11.04633747
44STK111.03739327
45UHMK11.03479410
46MAP3K131.03031221
47LATS21.02727961
48JAK11.02024988
49CAMK11.01451265
50RET1.00753647
51CSK1.00490414
52ZAP701.00455317
53SGK21.00311271
54WNK10.96954488
55GRK50.96943616
56RIPK40.92538453
57CAMKK20.92509198
58MAPKAPK50.91051169
59DYRK1A0.90197800
60MAP3K110.89953743
61DMPK0.88452125
62PKN10.88092348
63TAOK10.87627646
64CDK190.86355030
65PRKCG0.86175241
66CAMK2B0.85382338
67KSR10.85110385
68MAP3K70.84332179
69PNCK0.83583274
70FES0.83383142
71ALK0.82797777
72FGR0.81865830
73CAMK2G0.81069511
74PAK30.79317190
75KIT0.79292545
76MAPK100.74560767
77PRKD10.74543860
78CAMK2A0.74094257
79SIK10.73455674
80FGFR30.73158353
81WNK40.71441676
82NEK60.71286364
83SGK10.70555735
84MAP3K10.69247377
85EPHA30.69140569
86JAK30.67674607
87ERBB20.67071178
88MARK20.67022140
89SYK0.65624231
90IRAK20.64942938
91BCKDK0.64525142
92CAMK2D0.64493076
93ARAF0.63786580
94ERN10.63711283
95PRPF4B0.63630843
96TNIK0.63585933
97CDK150.62581111
98FGFR40.62071233
99CDK140.61780153
100SIK20.60685355
101CAMK40.60256989
102MAP2K30.60241413
103MAPK120.59923716
104EPHB10.59150978
105DAPK10.59131402
106PDK20.59066960
107RPS6KA30.58999902
108CDK180.58054189
109MAP3K140.57603217
110CSNK1G20.56810555
111MAPK40.56460714
112PRKCZ0.56075493
113PDGFRA0.54114937
114MAPK70.53495654
115PTK2B0.53214357
116TNK20.53088043
117TBK10.51070128
118HCK0.50804089
119PLK20.50592572
120ROCK20.50511799
121DAPK30.50128854
122MUSK0.50004850
123CDK11A0.49444589
124MOS0.49285507
125CDC42BPA0.48544347
126FYN0.48364482
127MAP3K60.46952696
128BMX0.46445386
129PRKACG0.45542260
130INSRR0.44947022
131MAPK130.44649750
132ICK0.44298606
133MAP2K10.42724758
134MAP3K30.42694796
135TAOK20.39572656

Predicted pathways (KEGG)

RankGene SetZ-score
1* Nitrogen metabolism_Homo sapiens_hsa009103.05238297
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.37738754
3Synaptic vesicle cycle_Homo sapiens_hsa047212.04302959
4* GABAergic synapse_Homo sapiens_hsa047271.99991852
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89910607
6Nicotine addiction_Homo sapiens_hsa050331.86213977
7Olfactory transduction_Homo sapiens_hsa047401.86178392
8Staphylococcus aureus infection_Homo sapiens_hsa051501.81461214
9Circadian entrainment_Homo sapiens_hsa047131.78048752
10* Glutamatergic synapse_Homo sapiens_hsa047241.77461932
11Salivary secretion_Homo sapiens_hsa049701.73051153
12Gastric acid secretion_Homo sapiens_hsa049711.67245483
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66550602
14Morphine addiction_Homo sapiens_hsa050321.63932208
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.62989049
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59628949
17Insulin secretion_Homo sapiens_hsa049111.57017971
18Bile secretion_Homo sapiens_hsa049761.55510175
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54938598
20Long-term potentiation_Homo sapiens_hsa047201.54685082
21Other glycan degradation_Homo sapiens_hsa005111.53918777
22Osteoclast differentiation_Homo sapiens_hsa043801.53578559
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52678728
24Fatty acid biosynthesis_Homo sapiens_hsa000611.50252816
25Amphetamine addiction_Homo sapiens_hsa050311.47513873
26* Arginine biosynthesis_Homo sapiens_hsa002201.43342413
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42933948
28Lysosome_Homo sapiens_hsa041421.41703726
29Butanoate metabolism_Homo sapiens_hsa006501.41484646
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38308945
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35166719
32* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34264085
33Dopaminergic synapse_Homo sapiens_hsa047281.28579866
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28340728
35Fatty acid metabolism_Homo sapiens_hsa012121.27266832
36Leishmaniasis_Homo sapiens_hsa051401.27157220
37Cholinergic synapse_Homo sapiens_hsa047251.27071940
38PPAR signaling pathway_Homo sapiens_hsa033201.25987727
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.25529416
40Renin secretion_Homo sapiens_hsa049241.19914749
41Tuberculosis_Homo sapiens_hsa051521.19894525
42Fatty acid degradation_Homo sapiens_hsa000711.18225393
43Propanoate metabolism_Homo sapiens_hsa006401.17087046
44Cocaine addiction_Homo sapiens_hsa050301.16003040
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14807922
46VEGF signaling pathway_Homo sapiens_hsa043701.12063425
47Collecting duct acid secretion_Homo sapiens_hsa049661.12036467
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11656213
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05890724
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04229143
51Pertussis_Homo sapiens_hsa051331.02888417
52Oxytocin signaling pathway_Homo sapiens_hsa049211.02732399
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.01303400
54cAMP signaling pathway_Homo sapiens_hsa040241.01229040
55Acute myeloid leukemia_Homo sapiens_hsa052210.98723218
56Type II diabetes mellitus_Homo sapiens_hsa049300.97765474
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94729022
58Phagosome_Homo sapiens_hsa041450.94289729
59Calcium signaling pathway_Homo sapiens_hsa040200.93212555
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93113516
61Inositol phosphate metabolism_Homo sapiens_hsa005620.92921471
62Dorso-ventral axis formation_Homo sapiens_hsa043200.92059617
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91919175
64Phototransduction_Homo sapiens_hsa047440.91399866
65Long-term depression_Homo sapiens_hsa047300.91387483
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89526717
67B cell receptor signaling pathway_Homo sapiens_hsa046620.89517844
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.87021501
69GnRH signaling pathway_Homo sapiens_hsa049120.86181437
70Mineral absorption_Homo sapiens_hsa049780.84900119
71Non-small cell lung cancer_Homo sapiens_hsa052230.84075406
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83928285
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.82298587
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81839928
75Gap junction_Homo sapiens_hsa045400.79580548
76Taste transduction_Homo sapiens_hsa047420.79146491
77HIF-1 signaling pathway_Homo sapiens_hsa040660.78869709
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78578984
79Chemokine signaling pathway_Homo sapiens_hsa040620.77287737
80Pancreatic secretion_Homo sapiens_hsa049720.76170193
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75415178
82Thyroid hormone synthesis_Homo sapiens_hsa049180.75400515
83Glycerolipid metabolism_Homo sapiens_hsa005610.75382089
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.74449868
85Vitamin B6 metabolism_Homo sapiens_hsa007500.74375887
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73890228
87Serotonergic synapse_Homo sapiens_hsa047260.73612572
88Estrogen signaling pathway_Homo sapiens_hsa049150.73383243
89Malaria_Homo sapiens_hsa051440.73040654
90* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72989721
91Tryptophan metabolism_Homo sapiens_hsa003800.72265886
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71604458
93Renal cell carcinoma_Homo sapiens_hsa052110.71492879
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71345538
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70988381
96beta-Alanine metabolism_Homo sapiens_hsa004100.69973592
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.68404241
98Glioma_Homo sapiens_hsa052140.67905920
99Prion diseases_Homo sapiens_hsa050200.67567628
100Phenylalanine metabolism_Homo sapiens_hsa003600.65533749
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65453258
102Legionellosis_Homo sapiens_hsa051340.65238636
103Complement and coagulation cascades_Homo sapiens_hsa046100.64035760
104Platelet activation_Homo sapiens_hsa046110.63806384
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.63469582
106Rheumatoid arthritis_Homo sapiens_hsa053230.63257029
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.62818681
108Amoebiasis_Homo sapiens_hsa051460.62737081
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.61627420
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61445820
111Glucagon signaling pathway_Homo sapiens_hsa049220.61153631
112Melanogenesis_Homo sapiens_hsa049160.60763565
113Fatty acid elongation_Homo sapiens_hsa000620.60689253
114Rap1 signaling pathway_Homo sapiens_hsa040150.58628364
115Peroxisome_Homo sapiens_hsa041460.57421826
116Endometrial cancer_Homo sapiens_hsa052130.57212999
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56991915
118Chronic myeloid leukemia_Homo sapiens_hsa052200.56517377
119mTOR signaling pathway_Homo sapiens_hsa041500.56166412
120ErbB signaling pathway_Homo sapiens_hsa040120.54599531
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51528582
122ABC transporters_Homo sapiens_hsa020100.50763087
123Pancreatic cancer_Homo sapiens_hsa052120.50285998
124Sulfur metabolism_Homo sapiens_hsa009200.50229714
125Dilated cardiomyopathy_Homo sapiens_hsa054140.49746490
126Choline metabolism in cancer_Homo sapiens_hsa052310.49019731
127Toxoplasmosis_Homo sapiens_hsa051450.48705288
128Pyruvate metabolism_Homo sapiens_hsa006200.48284154
129Salmonella infection_Homo sapiens_hsa051320.48163691
130Cardiac muscle contraction_Homo sapiens_hsa042600.46602443
131Endocytosis_Homo sapiens_hsa041440.45212562
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43769782
133Axon guidance_Homo sapiens_hsa043600.43720442
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42825765
135Carbon metabolism_Homo sapiens_hsa012000.42490053
136Caffeine metabolism_Homo sapiens_hsa002320.41492204
137Insulin resistance_Homo sapiens_hsa049310.41242477
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40926671
139Histidine metabolism_Homo sapiens_hsa003400.40779172
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40735914
141Circadian rhythm_Homo sapiens_hsa047100.39711373
142Insulin signaling pathway_Homo sapiens_hsa049100.38917946
143AMPK signaling pathway_Homo sapiens_hsa041520.38796154

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