ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	resolution of meiotic recombination intermediates (GO:0000712)	5.84324303
2	rRNA modification (GO:0000154)	5.03630870
3	protein deneddylation (GO:0000338)	4.89081807
4	rRNA methylation (GO:0031167)	4.60463220
5	aldehyde catabolic process (GO:0046185)	4.52012125
6	cullin deneddylation (GO:0010388)	4.33104477
7	peptidyl-arginine methylation (GO:0018216)	4.15745069
8	peptidyl-arginine N-methylation (GO:0035246)	4.15745069
9	maturation of 5.8S rRNA (GO:0000460)	4.15392857
10	DNA deamination (GO:0045006)	4.07259686
11	protein polyglutamylation (GO:0018095)	4.06971356
12	protein-cofactor linkage (GO:0018065)	4.06331958
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.93089602
14	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.85688294
15	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.80296546
16	mannosylation (GO:0097502)	3.78791301
17	ATP synthesis coupled proton transport (GO:0015986)	3.74334216
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.74334216
19	behavioral response to nicotine (GO:0035095)	3.73305125
20	proteasome assembly (GO:0043248)	3.65160232
21	DNA catabolic process, exonucleolytic (GO:0000738)	3.60899455
22	serotonin receptor signaling pathway (GO:0007210)	3.55959054
23	fatty acid elongation (GO:0030497)	3.53264468
24	negative regulation of protein acetylation (GO:1901984)	3.50586431
25	regulation of pigment cell differentiation (GO:0050932)	3.47616077
26	chaperone-mediated protein transport (GO:0072321)	3.46149181
27	neural tube formation (GO:0001841)	3.45985597
28	negative regulation of histone acetylation (GO:0035067)	3.43605160
29	ubiquinone biosynthetic process (GO:0006744)	3.41028788
30	peptidyl-arginine omega-N-methylation (GO:0035247)	3.40546616
31	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.37855136
32	positive regulation of developmental pigmentation (GO:0048087)	3.30890133
33	ribonucleoprotein complex disassembly (GO:0032988)	3.23672355
34	microtubule depolymerization (GO:0007019)	3.21577374
35	inner mitochondrial membrane organization (GO:0007007)	3.19115502
36	oxidative phosphorylation (GO:0006119)	3.17477404
37	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.15678349
38	negative regulation of interleukin-1 beta production (GO:0032691)	3.12135221
39	protein neddylation (GO:0045116)	3.10213334
40	protein prenylation (GO:0018342)	3.08736105
41	prenylation (GO:0097354)	3.08736105
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.07709816
43	ribosome assembly (GO:0042255)	3.07702744
44	ubiquinone metabolic process (GO:0006743)	3.05935383
45	rRNA catabolic process (GO:0016075)	3.03415151
46	lysine catabolic process (GO:0006554)	3.02259831
47	lysine metabolic process (GO:0006553)	3.02259831
48	response to pheromone (GO:0019236)	3.02206385
49	DNA double-strand break processing (GO:0000729)	3.00525769
50	negative regulation of epidermal cell differentiation (GO:0045605)	3.00456309
51	serotonin metabolic process (GO:0042428)	2.98577908
52	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97074680
53	primary amino compound metabolic process (GO:1901160)	2.94823999
54	synapsis (GO:0007129)	2.93889774
55	negative regulation of interleukin-1 production (GO:0032692)	2.92224709
56	histone H4-K12 acetylation (GO:0043983)	2.89715347
57	negative regulation of activin receptor signaling pathway (GO:0032926)	2.87178065
58	regulation of mitochondrial fission (GO:0090140)	2.85344818
59	positive regulation of mitochondrial fission (GO:0090141)	2.84290058
60	tRNA modification (GO:0006400)	2.77392918
61	regulation of cellular amino acid metabolic process (GO:0006521)	2.76571869
62	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.76233264
63	amino acid salvage (GO:0043102)	2.75083358
64	L-methionine salvage (GO:0071267)	2.75083358
65	L-methionine biosynthetic process (GO:0071265)	2.75083358
66	activated T cell proliferation (GO:0050798)	2.73858804
67	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.73098088
68	kynurenine metabolic process (GO:0070189)	2.71484434
69	dopamine biosynthetic process (GO:0042416)	2.71006565
70	ribosomal large subunit biogenesis (GO:0042273)	2.70441812
71	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.69851327
72	quinone biosynthetic process (GO:1901663)	2.69744094
73	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.66146142
74	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.65803538
75	positive regulation of mRNA 3-end processing (GO:0031442)	2.65224659
76	tryptophan metabolic process (GO:0006568)	2.63169271
77	negative regulation of peptidyl-lysine acetylation (GO:2000757)	2.62680233
78	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.62308876
79	regulation of mRNA 3-end processing (GO:0031440)	2.62197911
80	quinone metabolic process (GO:1901661)	2.60424091
81	peptidyl-arginine modification (GO:0018195)	2.59262382
82	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.58652299
83	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.58652299
84	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.58652299
85	tryptophan catabolic process (GO:0006569)	2.56720688
86	indole-containing compound catabolic process (GO:0042436)	2.56720688
87	indolalkylamine catabolic process (GO:0046218)	2.56720688
88	respiratory electron transport chain (GO:0022904)	2.56178937
89	parturition (GO:0007567)	2.56008640
90	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.54552780
91	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.54552780
92	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.52199754
93	indole-containing compound metabolic process (GO:0042430)	2.51615884
94	pyrimidine nucleobase catabolic process (GO:0006208)	2.51042793
95	microtubule severing (GO:0051013)	2.51040705
96	protein K11-linked deubiquitination (GO:0035871)	2.50753580
97	histone arginine methylation (GO:0034969)	2.50634004
98	epithelial cilium movement (GO:0003351)	2.49222435
99	respiratory chain complex IV assembly (GO:0008535)	2.48536861
100	sleep (GO:0030431)	2.48482771

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	5.35034390
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.39165719
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.96131632
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.50302425
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.35179227
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.26339724
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.24341616
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99410511
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82624326
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.81216058
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.35397173
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31569576
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.31376935
14	VDR_22108803_ChIP-Seq_LS180_Human	2.28628249
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.23662872
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.16425021
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.07733105
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.00131758
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.88219841
20	EWS_26573619_Chip-Seq_HEK293_Human	1.83863860
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.74743517
22	GATA1_22025678_ChIP-Seq_K562_Human	1.72500717
23	FUS_26573619_Chip-Seq_HEK293_Human	1.72058334
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70530861
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.65660909
26	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.64678275
27	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.63487064
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.59835339
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.57674411
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57011310
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55999444
32	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.51132018
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50812042
34	GBX2_23144817_ChIP-Seq_PC3_Human	1.50776416
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46510180
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.44464149
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42784282
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41481358
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.41481358
40	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.38956706
41	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.37280301
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.37152090
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.36033249
44	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35407948
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34349448
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32594557
47	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.31426503
48	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29838105
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.26869514
50	P300_19829295_ChIP-Seq_ESCs_Human	1.26832560
51	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.25655078
52	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.23395250
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.21357168
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20489450
55	AR_25329375_ChIP-Seq_VCAP_Human	1.19824172
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19484887
57	NCOR_22424771_ChIP-Seq_293T_Human	1.14927188
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14367065
59	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.13851047
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13275896
61	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.12295747
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12132265
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11147058
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11147058
65	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.10875469
66	AR_20517297_ChIP-Seq_VCAP_Human	1.10050307
67	PHF8_20622853_ChIP-Seq_HELA_Human	1.09020577
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.08492547
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07911111
70	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07257732
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05546733
72	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04687568
73	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.04324895
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03648768
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03648768
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.03425986
77	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02827692
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02304514
79	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.01888390
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01785874
81	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00718271
82	NFYB_21822215_ChIP-Seq_K562_Human	1.00248699
83	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.99863054
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98633942
85	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96551506
86	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96263668
87	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95889068
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95410672
89	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95143691
90	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.94527701
91	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.94526657
92	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.94519843
93	TTF2_22483619_ChIP-Seq_HELA_Human	0.93969004
94	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.92880568
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.92838406
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92637861
97	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92369620
98	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.92369620
99	NFYA_21822215_ChIP-Seq_K562_Human	0.91856145
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91605581

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.46149628
2	MP0004147_increased_porphyrin_level	4.23804303
3	MP0004885_abnormal_endolymph	3.34115464
4	MP0002638_abnormal_pupillary_reflex	2.75549185
5	MP0002277_abnormal_respiratory_mucosa	2.74157704
6	MP0003880_abnormal_central_pattern	2.61924212
7	MP0003724_increased_susceptibility_to	2.43079280
8	MP0005075_abnormal_melanosome_morpholog	2.40354691
9	MP0006036_abnormal_mitochondrial_physio	2.29852453
10	MP0003646_muscle_fatigue	2.25039781
11	MP0002837_dystrophic_cardiac_calcinosis	2.21510414
12	MP0005167_abnormal_blood-brain_barrier	2.07294148
13	MP0004381_abnormal_hair_follicle	1.88667850
14	MP0001905_abnormal_dopamine_level	1.85753594
15	MP0008961_abnormal_basal_metabolism	1.85622822
16	MP0005646_abnormal_pituitary_gland	1.84918948
17	MP0003195_calcinosis	1.75869034
18	MP0004133_heterotaxia	1.73224339
19	MP0002736_abnormal_nociception_after	1.72904008
20	MP0002751_abnormal_autonomic_nervous	1.72759089
21	MP0003718_maternal_effect	1.72587100
22	MP0001485_abnormal_pinna_reflex	1.69570168
23	MP0002160_abnormal_reproductive_system	1.68649458
24	MP0008789_abnormal_olfactory_epithelium	1.67340696
25	MP0005084_abnormal_gallbladder_morpholo	1.67320073
26	MP0002102_abnormal_ear_morphology	1.64176269
27	MP0002938_white_spotting	1.63163156
28	MP0008995_early_reproductive_senescence	1.60244297
29	MP0006072_abnormal_retinal_apoptosis	1.59255672
30	MP0001968_abnormal_touch/_nociception	1.56961739
31	MP0008872_abnormal_physiological_respon	1.51640706
32	MP0002095_abnormal_skin_pigmentation	1.49565085
33	MP0002876_abnormal_thyroid_physiology	1.48296366
34	MP0002272_abnormal_nervous_system	1.47225312
35	MP0003436_decreased_susceptibility_to	1.42252134
36	MP0005389_reproductive_system_phenotype	1.41768830
37	MP0005310_abnormal_salivary_gland	1.36372397
38	MP0002139_abnormal_hepatobiliary_system	1.35022093
39	MP0004043_abnormal_pH_regulation	1.34504378
40	MP0005645_abnormal_hypothalamus_physiol	1.31014582
41	MP0004742_abnormal_vestibular_system	1.30462482
42	MP0005551_abnormal_eye_electrophysiolog	1.28470217
43	MP0004142_abnormal_muscle_tone	1.28048525
44	MP0009046_muscle_twitch	1.27996347
45	MP0003786_premature_aging	1.27177804
46	MP0002254_reproductive_system_inflammat	1.19824620
47	MP0000465_gastrointestinal_hemorrhage	1.17529305
48	MP0006292_abnormal_olfactory_placode	1.15929780
49	MP0004215_abnormal_myocardial_fiber	1.15603032
50	MP0001440_abnormal_grooming_behavior	1.13439853
51	MP0003186_abnormal_redox_activity	1.12024923
52	MP0010386_abnormal_urinary_bladder	1.10624118
53	MP0005220_abnormal_exocrine_pancreas	1.08531419
54	MP0005671_abnormal_response_to	1.03760061
55	MP0005394_taste/olfaction_phenotype	1.01511417
56	MP0005499_abnormal_olfactory_system	1.01511417
57	MP0008058_abnormal_DNA_repair	0.99987374
58	MP0002234_abnormal_pharynx_morphology	0.98457684
59	MP0003252_abnormal_bile_duct	0.98117165
60	MP0001501_abnormal_sleep_pattern	0.95136177
61	MP0002928_abnormal_bile_duct	0.94371897
62	MP0009764_decreased_sensitivity_to	0.93273355
63	MP0003638_abnormal_response/metabolism_	0.89069737
64	MP0004957_abnormal_blastocyst_morpholog	0.89017674
65	MP0009697_abnormal_copulation	0.88590712
66	MP0001533_abnormal_skeleton_physiology	0.87615175
67	MP0009745_abnormal_behavioral_response	0.86747438
68	MP0008932_abnormal_embryonic_tissue	0.86055710
69	MP0006035_abnormal_mitochondrial_morpho	0.85887819
70	MP0002210_abnormal_sex_determination	0.85514906
71	MP0001986_abnormal_taste_sensitivity	0.85386444
72	MP0004883_abnormal_blood_vessel	0.84637607
73	MP0010329_abnormal_lipoprotein_level	0.83460373
74	MP0003137_abnormal_impulse_conducting	0.82864941
75	MP0002166_altered_tumor_susceptibility	0.82190499
76	MP0005000_abnormal_immune_tolerance	0.82071882
77	MP0000230_abnormal_systemic_arterial	0.79767718
78	MP0005332_abnormal_amino_acid	0.79383844
79	MP0008775_abnormal_heart_ventricle	0.77570018
80	MP0003119_abnormal_digestive_system	0.77167497
81	MP0001929_abnormal_gametogenesis	0.77110657
82	MP0002006_tumorigenesis	0.75996255
83	MP0001881_abnormal_mammary_gland	0.74417203
84	MP0002148_abnormal_hypersensitivity_rea	0.73370520
85	MP0009785_altered_susceptibility_to	0.72793318
86	MP0003866_abnormal_defecation	0.72697108
87	MP0008875_abnormal_xenobiotic_pharmacok	0.70302579
88	MP0005253_abnormal_eye_physiology	0.70058295
89	MP0004145_abnormal_muscle_electrophysio	0.69597821
90	MP0001756_abnormal_urination	0.69038777
91	MP0002067_abnormal_sensory_capabilities	0.67799173
92	MP0002572_abnormal_emotion/affect_behav	0.66563298
93	MP0002064_seizures	0.64806963
94	MP0001486_abnormal_startle_reflex	0.63419845
95	MP0001765_abnormal_ion_homeostasis	0.61830447
96	MP0002933_joint_inflammation	0.59797348
97	MP0005410_abnormal_fertilization	0.57892112
98	MP0003943_abnormal_hepatobiliary_system	0.57127247
99	MP0000653_abnormal_sex_gland	0.56333952
100	MP0000372_irregular_coat_pigmentation	0.55867237

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.63033968
2	Abnormality of alanine metabolism (HP:0010916)	4.63033968
3	Hyperalaninemia (HP:0003348)	4.63033968
4	Hyperglycinemia (HP:0002154)	4.32904596
5	Gonadotropin excess (HP:0000837)	3.53784530
6	Increased hepatocellular lipid droplets (HP:0006565)	3.39757250
7	Increased CSF lactate (HP:0002490)	3.38715353
8	Abnormality of the renal cortex (HP:0011035)	3.37100808
9	Tubulointerstitial nephritis (HP:0001970)	3.33492963
10	Limb dystonia (HP:0002451)	3.31093492
11	Hepatocellular necrosis (HP:0001404)	3.26301029
12	Hyperglycinuria (HP:0003108)	3.22863636
13	Neuroendocrine neoplasm (HP:0100634)	3.13520585
14	Renal cortical cysts (HP:0000803)	3.10523840
15	Hepatic necrosis (HP:0002605)	3.10506589
16	Lipid accumulation in hepatocytes (HP:0006561)	3.09798035
17	Type I diabetes mellitus (HP:0100651)	3.08207251
18	Mitochondrial inheritance (HP:0001427)	3.06725344
19	Abnormality of serum amino acid levels (HP:0003112)	2.94206435
20	Poor head control (HP:0002421)	2.81502645
21	Abnormality of serine family amino acid metabolism (HP:0010894)	2.81314298
22	Abnormality of glycine metabolism (HP:0010895)	2.81314298
23	Congenital stationary night blindness (HP:0007642)	2.78994079
24	Acute encephalopathy (HP:0006846)	2.75123852
25	Tinnitus (HP:0000360)	2.68365645
26	Tongue fasciculations (HP:0001308)	2.66689078
27	Abnormality of the prostate (HP:0008775)	2.64112250
28	Congenital sensorineural hearing impairment (HP:0008527)	2.63877219
29	Abnormality of the costochondral junction (HP:0000919)	2.61895728
30	Type 2 muscle fiber atrophy (HP:0003554)	2.61088518
31	Prostate neoplasm (HP:0100787)	2.58539262
32	Tubulointerstitial abnormality (HP:0001969)	2.58315226
33	Supernumerary spleens (HP:0009799)	2.57977469
34	Pancreatic cysts (HP:0001737)	2.57958682
35	Aplastic anemia (HP:0001915)	2.54712833
36	Attenuation of retinal blood vessels (HP:0007843)	2.50935402
37	Increased serum lactate (HP:0002151)	2.46265779
38	Methylmalonic acidemia (HP:0002912)	2.45688907
39	Abnormal protein glycosylation (HP:0012346)	2.44673758
40	Abnormal glycosylation (HP:0012345)	2.44673758
41	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.44673758
42	Abnormal protein N-linked glycosylation (HP:0012347)	2.44673758
43	Type I transferrin isoform profile (HP:0003642)	2.43887202
44	Conical tooth (HP:0000698)	2.43144201
45	Abolished electroretinogram (ERG) (HP:0000550)	2.40228764
46	Abnormality of the renal medulla (HP:0100957)	2.35147092
47	Pancytopenia (HP:0001876)	2.34080491
48	Abnormality of the vocal cords (HP:0008777)	2.34036438
49	Abnormal drinking behavior (HP:0030082)	2.33418566
50	Polydipsia (HP:0001959)	2.33418566
51	Acute necrotizing encephalopathy (HP:0006965)	2.27089830
52	Pancreatic fibrosis (HP:0100732)	2.23680713
53	Muscle fibrillation (HP:0010546)	2.21176812
54	CNS hypomyelination (HP:0003429)	2.16253773
55	Congenital, generalized hypertrichosis (HP:0004540)	2.15613230
56	Hyperammonemia (HP:0001987)	2.13411021
57	CNS demyelination (HP:0007305)	2.12689368
58	Spinal muscular atrophy (HP:0007269)	2.12443286
59	Rhinitis (HP:0012384)	2.09791751
60	Abnormal mitochondria in muscle tissue (HP:0008316)	2.04517533
61	Polyuria (HP:0000103)	2.04287882
62	Upper limb muscle weakness (HP:0003484)	2.03980545
63	Reduced antithrombin III activity (HP:0001976)	2.03908686
64	Renal Fanconi syndrome (HP:0001994)	2.03623370
65	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.03498061
66	Ulnar claw (HP:0001178)	2.02230938
67	3-Methylglutaconic aciduria (HP:0003535)	2.01889114
68	Increased intramyocellular lipid droplets (HP:0012240)	1.99996766
69	Abnormal biliary tract physiology (HP:0012439)	1.98564901
70	Bile duct proliferation (HP:0001408)	1.98564901
71	Lactic acidosis (HP:0003128)	1.98463320
72	Short tibia (HP:0005736)	1.98453589
73	Muscle fiber atrophy (HP:0100295)	1.98393507
74	Confusion (HP:0001289)	1.97721992
75	Hypokalemic alkalosis (HP:0001949)	1.97161194
76	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.96500836
77	Stomach cancer (HP:0012126)	1.95651847
78	Medial flaring of the eyebrow (HP:0010747)	1.95253087
79	Cerebral edema (HP:0002181)	1.94998494
80	Abnormal number of erythroid precursors (HP:0012131)	1.93578274
81	Emotional lability (HP:0000712)	1.93293698
82	True hermaphroditism (HP:0010459)	1.92995585
83	Thyroid-stimulating hormone excess (HP:0002925)	1.91990099
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.89462499
85	Severe combined immunodeficiency (HP:0004430)	1.87828242
86	Metaphyseal dysplasia (HP:0100255)	1.87541925
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.86453174
88	Methylmalonic aciduria (HP:0012120)	1.85734731
89	Exertional dyspnea (HP:0002875)	1.84958068
90	Chorioretinal atrophy (HP:0000533)	1.81274275
91	Tubulointerstitial fibrosis (HP:0005576)	1.80066153
92	Optic disc pallor (HP:0000543)	1.79333431
93	Midline defect of the nose (HP:0004122)	1.79023015
94	Absent thumb (HP:0009777)	1.77517177
95	Metabolic acidosis (HP:0001942)	1.77232804
96	Abnormality of the anterior horn cell (HP:0006802)	1.75445976
97	Degeneration of anterior horn cells (HP:0002398)	1.75445976
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.75199211
99	Respiratory failure (HP:0002878)	1.75095737
100	Pancreatitis (HP:0001733)	1.74155771

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.74897255
2	BUB1	3.30276009
3	TAOK3	3.29037862
4	STK39	3.09015130
5	EIF2AK3	2.92128650
6	RPS6KA4	2.88569659
7	NUAK1	2.79286784
8	TIE1	2.77425624
9	TLK1	2.60759644
10	OXSR1	2.54143743
11	ACVR1B	2.53069982
12	MAP2K2	2.47088684
13	TRIM28	2.39826369
14	EIF2AK1	2.28665878
15	MAP3K14	2.18744103
16	ZAK	2.17693248
17	WNK3	2.10995964
18	STK16	2.04025013
19	EIF2AK2	1.97898851
20	MKNK2	1.93032397
21	CAMKK2	1.90329197
22	GRK1	1.90114156
23	IKBKB	1.75567840
24	IKBKE	1.73954918
25	MKNK1	1.73729632
26	WNK4	1.54713683
27	CAMK1D	1.46591984
28	ADRBK2	1.46137061
29	KIT	1.42883794
30	TESK2	1.40870934
31	CDK19	1.37742840
32	RPS6KA5	1.26625560
33	TBK1	1.23182752
34	ERBB3	1.11878106
35	CHUK	1.08791344
36	MAPK13	1.06552944
37	BRD4	0.98964656
38	MAP4K2	0.95791467
39	PHKG2	0.94253667
40	PHKG1	0.94253667
41	TRPM7	0.90955977
42	CSNK1G1	0.89778588
43	TEC	0.84627579
44	BMPR1B	0.83591740
45	CSNK1G3	0.80715754
46	DYRK1A	0.80228483
47	TGFBR2	0.78908287
48	GRK7	0.76183941
49	CDC7	0.74971542
50	DAPK1	0.73973183
51	LIMK1	0.73056084
52	CAMK1G	0.70646566
53	ERN1	0.69804514
54	MST4	0.65892893
55	GRK5	0.62504519
56	CSNK1A1L	0.62215089
57	PDK2	0.61642680
58	EPHA4	0.61564807
59	NME1	0.59174255
60	CAMK1	0.55804480
61	VRK2	0.55449512
62	VRK1	0.49558346
63	PNCK	0.49267896
64	CAMK4	0.48913449
65	MATK	0.48503128
66	RIPK4	0.47414156
67	RPS6KA1	0.46300103
68	FRK	0.46138938
69	ABL1	0.45469014
70	INSRR	0.43404864
71	PLK4	0.43212017
72	BCR	0.42358585
73	ITK	0.41862925
74	CSNK1A1	0.39498139
75	TAF1	0.39444961
76	ERBB4	0.39390860
77	BCKDK	0.38508181
78	CSNK1G2	0.38362223
79	YES1	0.37058834
80	PRKCQ	0.36893971
81	LYN	0.35201706
82	MARK1	0.35079722
83	MAPKAPK3	0.35033257
84	MAP2K1	0.34391777
85	ADRBK1	0.29674098
86	TSSK6	0.28295121
87	ABL2	0.28068919
88	PRKCG	0.28007425
89	PLK2	0.27670056
90	LCK	0.26568123
91	PLK3	0.25516282
92	NEK1	0.25479183
93	PRKCE	0.23311616
94	CDK3	0.22494224
95	CSNK2A1	0.22322659
96	ERBB2	0.21867965
97	DYRK2	0.21661543
98	PIK3CG	0.21491469
99	MAPKAPK5	0.21396104
100	PLK1	0.21280705

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.01024222
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.76753657
3	Propanoate metabolism_Homo sapiens_hsa00640	3.23210764
4	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.80448106
5	Fatty acid elongation_Homo sapiens_hsa00062	2.70674614
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.55385569
7	RNA polymerase_Homo sapiens_hsa03020	2.49794300
8	Parkinsons disease_Homo sapiens_hsa05012	2.41734781
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.38903226
10	Protein export_Homo sapiens_hsa03060	2.24740131
11	Mismatch repair_Homo sapiens_hsa03430	2.04403916
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.92620813
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.90997369
14	beta-Alanine metabolism_Homo sapiens_hsa00410	1.84488568
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.84082340
16	Ribosome_Homo sapiens_hsa03010	1.78832966
17	RNA degradation_Homo sapiens_hsa03018	1.77999825
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.72378920
19	Spliceosome_Homo sapiens_hsa03040	1.62033249
20	Huntingtons disease_Homo sapiens_hsa05016	1.61775212
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.58800464
22	Basal transcription factors_Homo sapiens_hsa03022	1.54022664
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.50817309
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.50304486
25	Sulfur metabolism_Homo sapiens_hsa00920	1.44527387
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.42864245
27	One carbon pool by folate_Homo sapiens_hsa00670	1.42723116
28	RNA transport_Homo sapiens_hsa03013	1.35773054
29	Taste transduction_Homo sapiens_hsa04742	1.30182653
30	Homologous recombination_Homo sapiens_hsa03440	1.27028477
31	Glycerolipid metabolism_Homo sapiens_hsa00561	1.24523699
32	Phototransduction_Homo sapiens_hsa04744	1.22941881
33	Butanoate metabolism_Homo sapiens_hsa00650	1.22031924
34	Alzheimers disease_Homo sapiens_hsa05010	1.19954814
35	Sulfur relay system_Homo sapiens_hsa04122	1.18818377
36	Nicotine addiction_Homo sapiens_hsa05033	1.15758714
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.11340201
38	Purine metabolism_Homo sapiens_hsa00230	1.11278295
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08784592
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.08537537
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07515303
42	Folate biosynthesis_Homo sapiens_hsa00790	1.06962985
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.05341521
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.03180945
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03043870
46	Fat digestion and absorption_Homo sapiens_hsa04975	1.02729621
47	p53 signaling pathway_Homo sapiens_hsa04115	1.02300782
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.97524980
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95507772
50	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.94913539
51	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.94488226
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90601818
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.89856701
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.89614301
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80420737
56	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.80248032
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.78202575
58	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.78104501
59	Rheumatoid arthritis_Homo sapiens_hsa05323	0.77354326
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77140934
61	Histidine metabolism_Homo sapiens_hsa00340	0.71383489
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.70055471
63	Metabolic pathways_Homo sapiens_hsa01100	0.69647149
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.67668932
65	Asthma_Homo sapiens_hsa05310	0.67633817
66	Legionellosis_Homo sapiens_hsa05134	0.67536012
67	Peroxisome_Homo sapiens_hsa04146	0.66310857
68	Primary immunodeficiency_Homo sapiens_hsa05340	0.63350452
69	DNA replication_Homo sapiens_hsa03030	0.62863062
70	Caffeine metabolism_Homo sapiens_hsa00232	0.61960346
71	Olfactory transduction_Homo sapiens_hsa04740	0.61005495
72	Retinol metabolism_Homo sapiens_hsa00830	0.56296036
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53796844
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53069169
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52111967
76	Allograft rejection_Homo sapiens_hsa05330	0.52081903
77	Measles_Homo sapiens_hsa05162	0.51958584
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50569177
79	Malaria_Homo sapiens_hsa05144	0.50300852
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49856624
81	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48108314
82	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.47019049
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46937550
84	Arginine biosynthesis_Homo sapiens_hsa00220	0.46911025
85	Nucleotide excision repair_Homo sapiens_hsa03420	0.44274651
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41818297
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41737596
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.40141187
89	Mineral absorption_Homo sapiens_hsa04978	0.39715996
90	Graft-versus-host disease_Homo sapiens_hsa05332	0.38892786
91	Pancreatic secretion_Homo sapiens_hsa04972	0.38817944
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38637614
93	Glutathione metabolism_Homo sapiens_hsa00480	0.37412487
94	Type I diabetes mellitus_Homo sapiens_hsa04940	0.36994594
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36774546
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.36764046
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35431174
98	Antigen processing and presentation_Homo sapiens_hsa04612	0.35081263
99	Serotonergic synapse_Homo sapiens_hsa04726	0.34149502
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.31436712

GLULP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »