ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	4.95273361
2	indole-containing compound catabolic process (GO:0042436)	4.90169097
3	indolalkylamine catabolic process (GO:0046218)	4.90169097
4	tryptophan catabolic process (GO:0006569)	4.90169097
5	tryptophan metabolic process (GO:0006568)	4.83444015
6	kynurenine metabolic process (GO:0070189)	4.70441777
7	positive regulation of protein homodimerization activity (GO:0090073)	4.48211816
8	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	4.41385345
9	behavioral response to nicotine (GO:0035095)	4.11978142
10	regulation of cytokine secretion involved in immune response (GO:0002739)	4.01943506
11	indolalkylamine metabolic process (GO:0006586)	3.96841024
12	DNA deamination (GO:0045006)	3.94340618
13	fucose catabolic process (GO:0019317)	3.90739077
14	L-fucose metabolic process (GO:0042354)	3.90739077
15	L-fucose catabolic process (GO:0042355)	3.90739077
16	glyoxylate metabolic process (GO:0046487)	3.90546449
17	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.87692567
18	S-adenosylmethionine metabolic process (GO:0046500)	3.85803926
19	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.79356070
20	transcription from mitochondrial promoter (GO:0006390)	3.76373033
21	cellular biogenic amine catabolic process (GO:0042402)	3.75486521
22	amine catabolic process (GO:0009310)	3.75486521
23	opioid receptor signaling pathway (GO:0038003)	3.74615260
24	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.73835983
25	amino acid salvage (GO:0043102)	3.63489943
26	L-methionine salvage (GO:0071267)	3.63489943
27	L-methionine biosynthetic process (GO:0071265)	3.63489943
28	mitochondrial RNA metabolic process (GO:0000959)	3.55471963
29	neurotransmitter uptake (GO:0001504)	3.55234757
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.49627125
31	respiratory chain complex IV assembly (GO:0008535)	3.34330773
32	NAD biosynthetic process (GO:0009435)	3.34048326
33	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.27033427
34	regulation of cilium movement (GO:0003352)	3.23935129
35	maturation of 5.8S rRNA (GO:0000460)	3.20151506
36	aromatic amino acid family catabolic process (GO:0009074)	3.18717343
37	platelet dense granule organization (GO:0060155)	3.15231351
38	cellular response to ATP (GO:0071318)	3.08464234
39	indole-containing compound metabolic process (GO:0042430)	3.08037343
40	rRNA methylation (GO:0031167)	3.05727411
41	positive regulation of glycolytic process (GO:0045821)	3.04511179
42	prostate gland growth (GO:0060736)	3.03466849
43	regulation of meiosis I (GO:0060631)	3.02484298
44	aspartate family amino acid catabolic process (GO:0009068)	3.00177720
45	arginine metabolic process (GO:0006525)	2.99089945
46	dicarboxylic acid catabolic process (GO:0043649)	2.96284794
47	rRNA modification (GO:0000154)	2.94976183
48	cytokine biosynthetic process (GO:0042089)	2.93976575
49	negative regulation of thymocyte apoptotic process (GO:0070244)	2.89598513
50	multicellular organism reproduction (GO:0032504)	2.88887693
51	artery smooth muscle contraction (GO:0014824)	2.87414432
52	photoreceptor cell maintenance (GO:0045494)	2.87278620
53	autophagic vacuole fusion (GO:0000046)	2.84707234
54	methionine biosynthetic process (GO:0009086)	2.83790404
55	drug catabolic process (GO:0042737)	2.79616398
56	negative regulation of interleukin-1 production (GO:0032692)	2.79362663
57	negative regulation of protein oligomerization (GO:0032460)	2.78962934
58	oxidative demethylation (GO:0070989)	2.77173907
59	lysine catabolic process (GO:0006554)	2.76135441
60	lysine metabolic process (GO:0006553)	2.76135441
61	RNA destabilization (GO:0050779)	2.73388863
62	regulation of microtubule-based movement (GO:0060632)	2.72355759
63	positive regulation of chemokine biosynthetic process (GO:0045080)	2.72219645
64	protein import into peroxisome matrix (GO:0016558)	2.71845017
65	histone mRNA catabolic process (GO:0071044)	2.71134581
66	cellular response to leptin stimulus (GO:0044320)	2.69736617
67	adenosine metabolic process (GO:0046085)	2.69648554
68	negative regulation of B cell apoptotic process (GO:0002903)	2.69135855
69	cytochrome complex assembly (GO:0017004)	2.68447511
70	immunoglobulin mediated immune response (GO:0016064)	2.67214060
71	protein neddylation (GO:0045116)	2.67005230
72	pyridine nucleotide biosynthetic process (GO:0019363)	2.66594196
73	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.66594196
74	reverse cholesterol transport (GO:0043691)	2.66119119
75	regulation of B cell apoptotic process (GO:0002902)	2.63991875
76	methionine metabolic process (GO:0006555)	2.63723929
77	brain morphogenesis (GO:0048854)	2.61819613
78	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.59572115
79	terpenoid biosynthetic process (GO:0016114)	2.59028824
80	organelle disassembly (GO:1903008)	2.57634266
81	biotin metabolic process (GO:0006768)	2.56075827
82	high-density lipoprotein particle remodeling (GO:0034375)	2.55117053
83	heme transport (GO:0015886)	2.53265376
84	drug metabolic process (GO:0017144)	2.52759916
85	benzene-containing compound metabolic process (GO:0042537)	2.48689799
86	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.45870289
87	tonic smooth muscle contraction (GO:0014820)	2.45249570
88	preassembly of GPI anchor in ER membrane (GO:0016254)	2.44008194
89	aromatic amino acid family metabolic process (GO:0009072)	2.42384071
90	cytokine metabolic process (GO:0042107)	2.41312272
91	negative regulation of interleukin-1 beta production (GO:0032691)	2.40449240
92	regulation of podosome assembly (GO:0071801)	2.39604600
93	phospholipid translocation (GO:0045332)	2.39175953
94	lipid translocation (GO:0034204)	2.39175953
95	regulation of cholesterol esterification (GO:0010872)	2.38682756
96	regulation of interferon-alpha production (GO:0032647)	2.37055646
97	lactate metabolic process (GO:0006089)	2.35893966
98	DNA double-strand break processing (GO:0000729)	2.35850923
99	negative regulation of mast cell activation (GO:0033004)	2.35394429
100	aldehyde catabolic process (GO:0046185)	2.34649219

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.46697149
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.35601644
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.08896351
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.83741564
5	VDR_22108803_ChIP-Seq_LS180_Human	2.69835668
6	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.59177647
7	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.55247282
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.44159755
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.36732066
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27479345
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.16463370
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.07825182
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.97568412
14	GBX2_23144817_ChIP-Seq_PC3_Human	1.96602804
15	IGF1R_20145208_ChIP-Seq_DFB_Human	1.91666653
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.82724719
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.80401676
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.79615505
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77248880
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.69611632
21	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.63433484
22	FUS_26573619_Chip-Seq_HEK293_Human	1.59947931
23	EGR1_19032775_ChIP-ChIP_M12_Human	1.59102398
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.55967779
25	AR_20517297_ChIP-Seq_VCAP_Human	1.54660308
26	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.54452629
27	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.48202392
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.47968035
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47968035
30	NCOR_22424771_ChIP-Seq_293T_Human	1.44762774
31	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.44316668
32	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.44299666
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43594033
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43594033
35	HOXB7_26014856_ChIP-Seq_BT474_Human	1.43290204
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.43206220
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42940785
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42940785
39	GATA3_26560356_Chip-Seq_TH2_Human	1.41497425
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.39177091
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36694796
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35619498
43	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.35391657
44	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.32496305
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30312321
46	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.29263693
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.28782223
48	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.28573989
49	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.28523028
50	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.28389415
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27933418
52	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.27712683
53	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.27467156
54	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.26020192
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.25311857
56	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24630673
57	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.23991149
58	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.23717485
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23195005
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22481033
61	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22324684
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21195738
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.20485177
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20053131
65	EWS_26573619_Chip-Seq_HEK293_Human	1.20051414
66	P300_19829295_ChIP-Seq_ESCs_Human	1.18153355
67	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.15738620
68	NANOG_20526341_ChIP-Seq_ESCs_Human	1.14764756
69	PHF8_20622853_ChIP-Seq_HELA_Human	1.14444811
70	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12735237
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12523429
72	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.10913843
73	STAT1_20625510_ChIP-Seq_HELA_Human	1.10595018
74	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09872528
75	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08816977
76	ERA_21632823_ChIP-Seq_H3396_Human	1.05801174
77	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05167685
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04457498
79	RBPJ_21746931_ChIP-Seq_IB4_Human	1.03929491
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02601438
81	NFYB_21822215_ChIP-Seq_K562_Human	1.02110232
82	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01930436
83	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.01847230
84	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.01798372
85	ELK1_19687146_ChIP-ChIP_HELA_Human	1.01630355
86	AR_25329375_ChIP-Seq_VCAP_Human	1.01253740
87	FOXP3_21729870_ChIP-Seq_TREG_Human	1.00554769
88	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99841543
89	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.99657605
90	GATA4_25053715_ChIP-Seq_YYC3_Human	0.99480718
91	P300_18555785_Chip-Seq_ESCs_Mouse	0.98951026
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98518891
93	GATA1_22025678_ChIP-Seq_K562_Human	0.98413082
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.98310306
95	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97950127
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.97759774
97	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97528701
98	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.97214567
99	NFYA_21822215_ChIP-Seq_K562_Human	0.97126707
100	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.96345885

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.73191382
2	MP0004147_increased_porphyrin_level	3.12606488
3	MP0004043_abnormal_pH_regulation	2.82068341
4	MP0003806_abnormal_nucleotide_metabolis	2.80332659
5	MP0001986_abnormal_taste_sensitivity	2.71904697
6	MP0009764_decreased_sensitivity_to	2.69907288
7	MP0008875_abnormal_xenobiotic_pharmacok	2.47086712
8	MP0002138_abnormal_hepatobiliary_system	2.46843726
9	MP0000372_irregular_coat_pigmentation	2.41823123
10	MP0005167_abnormal_blood-brain_barrier	2.31364153
11	MP0005646_abnormal_pituitary_gland	2.26692081
12	MP0001501_abnormal_sleep_pattern	2.19753179
13	MP0005085_abnormal_gallbladder_physiolo	2.10208394
14	MP0010386_abnormal_urinary_bladder	2.09639458
15	MP0005365_abnormal_bile_salt	2.08423182
16	MP0006292_abnormal_olfactory_placode	2.04400072
17	MP0009697_abnormal_copulation	2.00164850
18	MP0002148_abnormal_hypersensitivity_rea	1.96772730
19	MP0008775_abnormal_heart_ventricle	1.95487268
20	MP0009785_altered_susceptibility_to	1.94531704
21	MP0008872_abnormal_physiological_respon	1.92970298
22	MP0005084_abnormal_gallbladder_morpholo	1.90039741
23	MP0005360_urolithiasis	1.86374300
24	MP0001835_abnormal_antigen_presentation	1.82258304
25	MP0003724_increased_susceptibility_to	1.80213530
26	MP0005332_abnormal_amino_acid	1.79965979
27	MP0004215_abnormal_myocardial_fiber	1.77792001
28	MP0010329_abnormal_lipoprotein_level	1.76715427
29	MP0004084_abnormal_cardiac_muscle	1.74221630
30	MP0002736_abnormal_nociception_after	1.73231355
31	MP0003191_abnormal_cellular_cholesterol	1.71388237
32	MP0005464_abnormal_platelet_physiology	1.65633060
33	MP0001968_abnormal_touch/_nociception	1.62774137
34	MP0008004_abnormal_stomach_pH	1.58957225
35	MP0005410_abnormal_fertilization	1.55040165
36	MP0001764_abnormal_homeostasis	1.53276237
37	MP0005075_abnormal_melanosome_morpholog	1.51983246
38	MP0002876_abnormal_thyroid_physiology	1.50316762
39	MP0002837_dystrophic_cardiac_calcinosis	1.49269600
40	MP0005551_abnormal_eye_electrophysiolog	1.47509393
41	MP0003718_maternal_effect	1.45920872
42	MP0008260_abnormal_autophagy	1.44039344
43	MP0006072_abnormal_retinal_apoptosis	1.38593093
44	MP0003075_altered_response_to	1.38514544
45	MP0002139_abnormal_hepatobiliary_system	1.30945770
46	MP0000383_abnormal_hair_follicle	1.29495059
47	MP0000427_abnormal_hair_cycle	1.29123977
48	MP0001661_extended_life_span	1.28135273
49	MP0008873_increased_physiological_sensi	1.24375385
50	MP0008007_abnormal_cellular_replicative	1.22761490
51	MP0004782_abnormal_surfactant_physiolog	1.15798821
52	MP0005220_abnormal_exocrine_pancreas	1.14743390
53	MP0008877_abnormal_DNA_methylation	1.14413820
54	MP0005253_abnormal_eye_physiology	1.13744098
55	MP0002132_abnormal_respiratory_system	1.12973893
56	MP0010155_abnormal_intestine_physiology	1.03067322
57	MP0001800_abnormal_humoral_immune	1.01308616
58	MP0003646_muscle_fatigue	1.01166760
59	MP0002735_abnormal_chemical_nociception	1.00747955
60	MP0008469_abnormal_protein_level	1.00544583
61	MP0000604_amyloidosis	1.00127827
62	MP0003123_paternal_imprinting	0.98813251
63	MP0003186_abnormal_redox_activity	0.98540936
64	MP0000230_abnormal_systemic_arterial	0.98442701
65	MP0002102_abnormal_ear_morphology	0.98206302
66	MP0009765_abnormal_xenobiotic_induced	0.96461230
67	MP0003436_decreased_susceptibility_to	0.96366892
68	MP0002452_abnormal_antigen_presenting	0.95739201
69	MP0009333_abnormal_splenocyte_physiolog	0.94066860
70	MP0005025_abnormal_response_to	0.93613747
71	MP0002118_abnormal_lipid_homeostasis	0.93361666
72	MP0002938_white_spotting	0.92787557
73	MP0005058_abnormal_lysosome_morphology	0.91860820
74	MP0001845_abnormal_inflammatory_respons	0.91700024
75	MP0002723_abnormal_immune_serum	0.91395455
76	MP0002733_abnormal_thermal_nociception	0.90576857
77	MP0003303_peritoneal_inflammation	0.90219049
78	MP0001666_abnormal_nutrient_absorption	0.90147755
79	MP0010678_abnormal_skin_adnexa	0.87593863
80	MP0005671_abnormal_response_to	0.87096780
81	MP0005000_abnormal_immune_tolerance	0.86962489
82	MP0002419_abnormal_innate_immunity	0.85889722
83	MP0003172_abnormal_lysosome_physiology	0.85811289
84	MP0001533_abnormal_skeleton_physiology	0.81708124
85	MP0003252_abnormal_bile_duct	0.80950115
86	MP0003880_abnormal_central_pattern	0.79928266
87	MP0001756_abnormal_urination	0.79102573
88	MP0005389_reproductive_system_phenotype	0.78395279
89	MP0003786_premature_aging	0.77785401
90	MP0002332_abnormal_exercise_endurance	0.76707173
91	MP0005319_abnormal_enzyme/_coenzyme	0.76622366
92	MP0005448_abnormal_energy_balance	0.75503011
93	MP0003787_abnormal_imprinting	0.73084099
94	MP0005535_abnormal_body_temperature	0.72347970
95	MP0009643_abnormal_urine_homeostasis	0.70240905
96	MP0005636_abnormal_mineral_homeostasis	0.69344165
97	MP0005386_behavior/neurological_phenoty	0.69267501
98	MP0004924_abnormal_behavior	0.69267501
99	MP0009745_abnormal_behavioral_response	0.68274991
100	MP0003121_genomic_imprinting	0.66502907

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Fair hair (HP:0002286)	3.83306416
2	Clumsiness (HP:0002312)	3.66423678
3	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.63047851
4	Delayed CNS myelination (HP:0002188)	3.50728716
5	Stomach cancer (HP:0012126)	3.49017363
6	Renal cortical cysts (HP:0000803)	3.48505806
7	Congenital stationary night blindness (HP:0007642)	3.48303278
8	Tubulointerstitial nephritis (HP:0001970)	3.41602278
9	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.34014037
10	Congenital, generalized hypertrichosis (HP:0004540)	3.32798508
11	Pancreatic cysts (HP:0001737)	3.24111362
12	Abnormality of the renal cortex (HP:0011035)	3.23463935
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.17437796
14	Abnormality of alanine metabolism (HP:0010916)	3.17437796
15	Hyperalaninemia (HP:0003348)	3.17437796
16	Pancreatic fibrosis (HP:0100732)	3.06260554
17	Chronic hepatic failure (HP:0100626)	3.01322966
18	Abolished electroretinogram (ERG) (HP:0000550)	3.01027027
19	Type I transferrin isoform profile (HP:0003642)	3.00407441
20	Stomatitis (HP:0010280)	2.96761898
21	Abnormality of the renal medulla (HP:0100957)	2.93191697
22	Increased IgM level (HP:0003496)	2.81962123
23	Acute encephalopathy (HP:0006846)	2.79948575
24	Nephronophthisis (HP:0000090)	2.79862505
25	Increased cerebral lipofuscin (HP:0011813)	2.79118347
26	Elevated erythrocyte sedimentation rate (HP:0003565)	2.70285102
27	Acute necrotizing encephalopathy (HP:0006965)	2.66704559
28	Abnormality of transition element cation homeostasis (HP:0011030)	2.63042861
29	Generalized hypopigmentation of hair (HP:0011358)	2.62775378
30	Abnormality of the periventricular white matter (HP:0002518)	2.62685922
31	Congenital hepatic fibrosis (HP:0002612)	2.58800734
32	Hyperammonemia (HP:0001987)	2.56909252
33	Autoimmune thrombocytopenia (HP:0001973)	2.55571166
34	CNS hypomyelination (HP:0003429)	2.55541424
35	Progressive macrocephaly (HP:0004481)	2.55142542
36	Brushfield spots (HP:0001088)	2.54796393
37	Increased CSF lactate (HP:0002490)	2.52651206
38	Mitochondrial inheritance (HP:0001427)	2.49312057
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.49291145
40	Decreased central vision (HP:0007663)	2.48033297
41	Abnormal protein glycosylation (HP:0012346)	2.47235392
42	Abnormal glycosylation (HP:0012345)	2.47235392
43	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.47235392
44	Abnormal protein N-linked glycosylation (HP:0012347)	2.47235392
45	True hermaphroditism (HP:0010459)	2.43148910
46	Attenuation of retinal blood vessels (HP:0007843)	2.37808274
47	Nausea (HP:0002018)	2.32375604
48	Concave nail (HP:0001598)	2.31922698
49	Methylmalonic acidemia (HP:0002912)	2.31454324
50	Abnormal biliary tract physiology (HP:0012439)	2.29950944
51	Bile duct proliferation (HP:0001408)	2.29950944
52	Abnormality of midbrain morphology (HP:0002418)	2.27429391
53	Molar tooth sign on MRI (HP:0002419)	2.27429391
54	Tubulointerstitial abnormality (HP:0001969)	2.27191136
55	Inability to walk (HP:0002540)	2.25870390
56	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.25214410
57	Amelogenesis imperfecta (HP:0000705)	2.22147104
58	Azoospermia (HP:0000027)	2.20893530
59	Pendular nystagmus (HP:0012043)	2.16161115
60	Hepatic necrosis (HP:0002605)	2.12539917
61	Lethargy (HP:0001254)	2.09287639
62	Anorexia (HP:0002039)	2.08259035
63	Pachygyria (HP:0001302)	2.07809330
64	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06675790
65	Mesangial abnormality (HP:0001966)	2.04243606
66	3-Methylglutaconic aciduria (HP:0003535)	2.04051343
67	Type II lissencephaly (HP:0007260)	2.03447310
68	Autoamputation (HP:0001218)	2.00864316
69	Tubular atrophy (HP:0000092)	2.00507109
70	Optic neuritis (HP:0100653)	1.94940477
71	Retrobulbar optic neuritis (HP:0100654)	1.94940477
72	Progressive inability to walk (HP:0002505)	1.94924925
73	Abnormality of iron homeostasis (HP:0011031)	1.94554655
74	Absent speech (HP:0001344)	1.94344573
75	Chorioretinal atrophy (HP:0000533)	1.92949662
76	Abnormality of B cell number (HP:0010975)	1.92847720
77	Broad-based gait (HP:0002136)	1.92008932
78	Cystic liver disease (HP:0006706)	1.91073802
79	Abnormality of serum amino acid levels (HP:0003112)	1.90601546
80	Widely spaced teeth (HP:0000687)	1.90368632
81	Protruding tongue (HP:0010808)	1.90316965
82	Submucous cleft hard palate (HP:0000176)	1.89456053
83	Hyperglycinemia (HP:0002154)	1.89059731
84	Lactic acidosis (HP:0003128)	1.89047411
85	Hepatocellular necrosis (HP:0001404)	1.88491371
86	Severe global developmental delay (HP:0011344)	1.87299706
87	Dry hair (HP:0011359)	1.87137130
88	Dicarboxylic aciduria (HP:0003215)	1.85685118
89	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.85685118
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.82195050
91	Optic disc pallor (HP:0000543)	1.81350004
92	Methylmalonic aciduria (HP:0012120)	1.81328809
93	Cerebral edema (HP:0002181)	1.80379446
94	Clubbing of toes (HP:0100760)	1.77831800
95	Metabolic acidosis (HP:0001942)	1.76082263
96	Autoimmune hemolytic anemia (HP:0001890)	1.75452338
97	Episodic fever (HP:0001954)	1.74745951
98	Large for gestational age (HP:0001520)	1.74338793
99	Furrowed tongue (HP:0000221)	1.73513055
100	Hyperglycinuria (HP:0003108)	1.71939762

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.07179578
2	BMPR1B	3.77934646
3	ADRBK2	3.38506393
4	TAOK3	3.33755623
5	EIF2AK3	3.11479663
6	FRK	3.05251440
7	ZAK	2.58120740
8	CAMKK2	2.40702834
9	PDK2	2.28892009
10	NUAK1	2.24554209
11	TRIM28	2.02565033
12	WNK4	2.01500088
13	MAP4K2	1.99719835
14	KIT	1.94528125
15	TLK1	1.86096145
16	PTK2B	1.82307089
17	CHUK	1.71711314
18	IKBKB	1.68217634
19	EIF2AK1	1.64712343
20	MST4	1.60138965
21	PHKG2	1.50782959
22	PHKG1	1.50782959
23	GRK1	1.48038587
24	MAP3K14	1.47416479
25	MET	1.47251180
26	BRSK2	1.45946126
27	STK16	1.44442147
28	PINK1	1.42587620
29	WNK3	1.34156988
30	TGFBR1	1.26444666
31	MAPKAPK3	1.26391017
32	TIE1	1.25585850
33	TBK1	1.23810552
34	STK4	1.20630004
35	IKBKE	1.20333888
36	RIPK4	1.11922182
37	OXSR1	1.08415556
38	NEK1	1.07051898
39	LMTK2	1.01791794
40	ADRBK1	0.99961142
41	TEC	0.99816711
42	TXK	0.96565414
43	MATK	0.89325033
44	DAPK2	0.89201148
45	VRK1	0.87423192
46	PLK3	0.86656580
47	RPS6KA5	0.85952034
48	IRAK4	0.82376784
49	STK3	0.77597675
50	SIK3	0.77202426
51	PLK4	0.74979027
52	GRK7	0.74893193
53	ITK	0.73663791
54	FES	0.72447140
55	TNK2	0.71887845
56	FLT3	0.71021482
57	CLK1	0.69965170
58	LYN	0.69091606
59	SYK	0.68210203
60	BCR	0.66355699
61	ABL1	0.64684784
62	PRKCE	0.64597456
63	PRKCQ	0.63966234
64	STK39	0.62109687
65	INSRR	0.61544247
66	IRAK1	0.61004138
67	ABL2	0.59855358
68	PRKG2	0.58167473
69	NTRK3	0.57804481
70	PAK3	0.55630478
71	PRKAA1	0.53779979
72	MAPK13	0.52989967
73	PIK3CA	0.51709192
74	CSF1R	0.48898125
75	MAP4K1	0.47940930
76	CAMKK1	0.47352461
77	EIF2AK2	0.45808033
78	CSNK1A1	0.44193058
79	BCKDK	0.44178560
80	MKNK1	0.43908039
81	PRKACG	0.42490737
82	PRKAA2	0.42283362
83	CSNK1D	0.41611312
84	BTK	0.41479086
85	PRKCG	0.40960840
86	FER	0.40480882
87	SRPK1	0.39651866
88	CAMK1D	0.37741739
89	HCK	0.36724667
90	MAP2K1	0.36387384
91	PRKCA	0.35414831
92	RPS6KA4	0.35310555
93	ATR	0.35088834
94	MKNK2	0.35040159
95	CSNK1G1	0.33780722
96	IGF1R	0.33160521
97	CAMK2D	0.32189279
98	PRKACA	0.31426747
99	IRAK3	0.30884055
100	IRAK2	0.30661510

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	5.16340060
2	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.99515553
3	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.72573103
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.43638689
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.40800089
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.37853113
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.24840033
8	Peroxisome_Homo sapiens_hsa04146	2.23047920
9	Proteasome_Homo sapiens_hsa03050	2.19872732
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.08341500
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.05344069
12	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.97482185
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.79156618
14	Phototransduction_Homo sapiens_hsa04744	1.70017464
15	Regulation of autophagy_Homo sapiens_hsa04140	1.68601259
16	beta-Alanine metabolism_Homo sapiens_hsa00410	1.61602587
17	Asthma_Homo sapiens_hsa05310	1.59340506
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54458987
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.53468692
20	Butanoate metabolism_Homo sapiens_hsa00650	1.48212577
21	Sulfur metabolism_Homo sapiens_hsa00920	1.47814850
22	RNA degradation_Homo sapiens_hsa03018	1.43637376
23	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.43015473
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.38998362
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.38698478
26	Allograft rejection_Homo sapiens_hsa05330	1.32587464
27	Histidine metabolism_Homo sapiens_hsa00340	1.32376596
28	Malaria_Homo sapiens_hsa05144	1.29883912
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.29544362
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.27754190
31	Propanoate metabolism_Homo sapiens_hsa00640	1.26229332
32	One carbon pool by folate_Homo sapiens_hsa00670	1.23511546
33	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.23170907
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.22215029
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.21849048
36	Legionellosis_Homo sapiens_hsa05134	1.19197568
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.18568429
38	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.18069460
39	Glutathione metabolism_Homo sapiens_hsa00480	1.15653693
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15579490
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.11929849
42	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.09161491
43	Complement and coagulation cascades_Homo sapiens_hsa04610	1.07343269
44	Non-homologous end-joining_Homo sapiens_hsa03450	1.05587159
45	Oxidative phosphorylation_Homo sapiens_hsa00190	1.05459207
46	African trypanosomiasis_Homo sapiens_hsa05143	1.05243272
47	Arginine and proline metabolism_Homo sapiens_hsa00330	1.03478973
48	Fat digestion and absorption_Homo sapiens_hsa04975	1.03180125
49	Graft-versus-host disease_Homo sapiens_hsa05332	1.01230104
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.00471830
51	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.00359453
52	Fatty acid degradation_Homo sapiens_hsa00071	1.00093841
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.98294958
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94715318
55	RNA polymerase_Homo sapiens_hsa03020	0.94470745
56	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.90586907
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88876363
58	Type I diabetes mellitus_Homo sapiens_hsa04940	0.87127074
59	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.86489466
60	Olfactory transduction_Homo sapiens_hsa04740	0.86234135
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83908919
62	Protein export_Homo sapiens_hsa03060	0.82365197
63	Retinol metabolism_Homo sapiens_hsa00830	0.82295944
64	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.80209674
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79482872
66	Fatty acid elongation_Homo sapiens_hsa00062	0.79438116
67	Caffeine metabolism_Homo sapiens_hsa00232	0.76651596
68	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.75085050
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74265999
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.73607608
71	ABC transporters_Homo sapiens_hsa02010	0.72538025
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70294864
73	Parkinsons disease_Homo sapiens_hsa05012	0.68538451
74	Homologous recombination_Homo sapiens_hsa03440	0.65349907
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60456870
76	Metabolic pathways_Homo sapiens_hsa01100	0.59838958
77	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59006000
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58215360
79	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.57910540
80	Pancreatic secretion_Homo sapiens_hsa04972	0.56665055
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51792740
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.51383211
83	Purine metabolism_Homo sapiens_hsa00230	0.50596450
84	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49890682
85	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.49455271
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48220110
87	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.47452558
88	Antigen processing and presentation_Homo sapiens_hsa04612	0.46577982
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45528387
90	Pertussis_Homo sapiens_hsa05133	0.45454899
91	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44627940
92	Bile secretion_Homo sapiens_hsa04976	0.42771814
93	Mineral absorption_Homo sapiens_hsa04978	0.41299740
94	Base excision repair_Homo sapiens_hsa03410	0.39441429
95	Lysosome_Homo sapiens_hsa04142	0.37647056
96	PPAR signaling pathway_Homo sapiens_hsa03320	0.37599426
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.36685167
98	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35850306
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35257415
100	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.32744564

GLULP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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