GLULP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)6.60030832
2modulation by symbiont of host defense response (GO:0052031)6.47309239
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.47309239
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.47309239
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.47309239
6modulation by symbiont of host immune response (GO:0052553)6.47309239
7positive regulation by symbiont of host defense response (GO:0052509)6.47309239
8detection of molecule of bacterial origin (GO:0032490)6.14366054
9positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.79891213
10positive regulation of gamma-delta T cell activation (GO:0046645)5.60818454
11macrophage activation involved in immune response (GO:0002281)5.51514807
12negative regulation of interleukin-12 production (GO:0032695)5.44897212
13cellular extravasation (GO:0045123)5.27875734
14neutrophil activation involved in immune response (GO:0002283)5.24978358
15neutrophil mediated immunity (GO:0002446)5.13759704
16microglial cell activation (GO:0001774)5.02883651
17regulation of interferon-beta biosynthetic process (GO:0045357)4.93855458
18positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.87745120
19detection of external biotic stimulus (GO:0098581)4.67625912
20response to host immune response (GO:0052572)4.62959644
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.62959644
22detection of other organism (GO:0098543)4.60859379
23macrophage activation (GO:0042116)4.59691594
24negative regulation of cell killing (GO:0031342)4.52878252
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.52878252
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.51743952
27detection of biotic stimulus (GO:0009595)4.40672600
28myeloid leukocyte mediated immunity (GO:0002444)4.26491884
29regulation of gamma-delta T cell activation (GO:0046643)4.22393554
30respiratory burst (GO:0045730)4.21731465
31response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.19739617
32response to host (GO:0075136)4.19739617
33response to host defenses (GO:0052200)4.19739617
34regulation of B cell receptor signaling pathway (GO:0050855)4.12803710
35regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.08515365
36neutrophil activation (GO:0042119)3.96534473
37regulation of interleukin-8 biosynthetic process (GO:0045414)3.90517517
38detection of bacterium (GO:0016045)3.86638120
39myeloid cell activation involved in immune response (GO:0002275)3.84504333
40regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.82410301
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79377070
42lipopolysaccharide-mediated signaling pathway (GO:0031663)3.78801651
43response to muramyl dipeptide (GO:0032495)3.72244250
44granulocyte activation (GO:0036230)3.67941556
45negative regulation of T cell mediated immunity (GO:0002710)3.63129844
46leukocyte aggregation (GO:0070486)3.58424619
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.56732054
48modulation of growth of symbiont involved in interaction with host (GO:0044144)3.56622461
49regulation of growth of symbiont in host (GO:0044126)3.56622461
50negative regulation of growth of symbiont in host (GO:0044130)3.56622461
51negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.56622461
52defense response to protozoan (GO:0042832)3.55237035
53regulation of macrophage cytokine production (GO:0010935)3.54675230
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.54009866
55cell wall macromolecule catabolic process (GO:0016998)3.50598410
56regulation of mast cell degranulation (GO:0043304)3.50282637
57positive regulation of interleukin-1 beta secretion (GO:0050718)3.47941257
58immunoglobulin mediated immune response (GO:0016064)3.47288881
59positive regulation of interferon-alpha production (GO:0032727)3.46375752
60regulation of gamma-delta T cell differentiation (GO:0045586)3.39897970
61regulation of interferon-alpha production (GO:0032647)3.38665560
62regulation of mast cell activation (GO:0033003)3.36972175
63regulation of mast cell activation involved in immune response (GO:0033006)3.34001357
64production of molecular mediator involved in inflammatory response (GO:0002532)3.33702274
65positive regulation of mast cell activation (GO:0033005)3.26469480
66positive regulation of interleukin-1 secretion (GO:0050716)3.26271348
67positive regulation of interferon-beta production (GO:0032728)3.24295048
68leukocyte migration involved in inflammatory response (GO:0002523)3.20538289
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.20267096
70response to protozoan (GO:0001562)3.19001624
71regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18505263
72positive regulation of toll-like receptor signaling pathway (GO:0034123)3.18250274
73positive regulation of interleukin-1 production (GO:0032732)3.12810093
74regulation of interleukin-1 beta secretion (GO:0050706)3.10148277
75T-helper 1 type immune response (GO:0042088)3.09015246
76positive regulation of cellular amide metabolic process (GO:0034250)3.08666267
77positive regulation of macrophage cytokine production (GO:0060907)3.08480675
78regulation of interleukin-6 biosynthetic process (GO:0045408)3.08003115
79negative regulation of interleukin-1 production (GO:0032692)3.05493296
80neutrophil chemotaxis (GO:0030593)3.04911106
81antigen processing and presentation of endogenous antigen (GO:0019883)3.04491265
82negative regulation of interleukin-1 beta production (GO:0032691)3.03451415
83regulation of leukocyte degranulation (GO:0043300)3.02318778
84negative regulation of leukocyte mediated immunity (GO:0002704)3.00514512
85positive regulation of interleukin-1 beta production (GO:0032731)3.00386608
86negative regulation of cytokine production involved in immune response (GO:0002719)2.99982907
87negative regulation of interleukin-6 production (GO:0032715)2.98651560
88neutrophil migration (GO:1990266)2.97042325
89negative regulation of interleukin-17 production (GO:0032700)2.94596319
90positive regulation of mast cell activation involved in immune response (GO:0033008)2.92672028
91positive regulation of mast cell degranulation (GO:0043306)2.92672028
92myeloid leukocyte activation (GO:0002274)2.91801512
93leukocyte degranulation (GO:0043299)2.89744530
94germinal center formation (GO:0002467)2.89095098
95reactive oxygen species biosynthetic process (GO:1903409)2.88073920
96regulation of interferon-beta production (GO:0032648)2.86911997
97regulation of tolerance induction (GO:0002643)2.86170088
98cell wall macromolecule metabolic process (GO:0044036)2.85742778
99cellular response to type I interferon (GO:0071357)2.84747148
100type I interferon signaling pathway (GO:0060337)2.84747148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.75448115
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.62901618
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.58575943
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95317897
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.78756679
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.69234660
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58407116
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.58342907
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.35009227
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94029996
11VDR_24763502_ChIP-Seq_THP-1_Human2.81519825
12SPI1_23547873_ChIP-Seq_NB4_Human2.80616076
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.76219717
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.68888065
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.68840603
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67138824
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.66533253
18VDR_21846776_ChIP-Seq_THP-1_Human2.66384552
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.62824904
20SPI1_23127762_ChIP-Seq_K562_Human2.60556996
21SCL_19346495_ChIP-Seq_HPC-7_Human2.54368845
22RUNX_20019798_ChIP-Seq_JUKART_Human2.44952715
23VDR_24787735_ChIP-Seq_THP-1_Human2.42117684
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27934923
25MYB_26560356_Chip-Seq_TH2_Human2.25423336
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13863879
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12792032
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12089611
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11600238
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06781046
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03553905
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03184371
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01089288
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98802566
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93998017
36MYB_26560356_Chip-Seq_TH1_Human1.85705792
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.82825894
38MAF_26560356_Chip-Seq_TH1_Human1.78845484
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.77311508
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71453323
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67743652
42GATA3_27048872_Chip-Seq_THYMUS_Human1.59951799
43UTX_26944678_Chip-Seq_JUKART_Human1.54541956
44GATA3_26560356_Chip-Seq_TH2_Human1.49536731
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47283475
46PU_27001747_Chip-Seq_BMDM_Mouse1.46658567
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42647173
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39272644
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35328584
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30742726
51GATA1_22025678_ChIP-Seq_K562_Human1.30291290
52TCF7_22412390_ChIP-Seq_EML_Mouse1.29735045
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.29113237
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28819222
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.28690004
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27342958
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22394950
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21325403
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20506888
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20459111
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20276834
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20182201
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19813637
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15398278
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14115391
66MAF_26560356_Chip-Seq_TH2_Human1.13644239
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12454059
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11177019
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10496341
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07385842
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06822757
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05534858
73KDM2B_26808549_Chip-Seq_DND41_Human1.04319752
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02945188
75MYC_22102868_ChIP-Seq_BL_Human1.00568993
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98442812
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95443552
78EGR1_19032775_ChIP-ChIP_M12_Human0.93963352
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90932024
80GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90802448
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90747443
82SMRT_27268052_Chip-Seq_Bcells_Human0.85994888
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85773056
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81737210
85ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79487159
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77228050
87RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74996874
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72589439
89GATA2_19941826_ChIP-Seq_K562_Human0.71901366
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.71890424
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70436242
92TFEB_21752829_ChIP-Seq_HELA_Human0.69067526
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.68831589
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.68535217
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68486358
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.68246624
97SPI1_20517297_ChIP-Seq_HL60_Human0.66883085
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.66465841
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65043767
100BCL6_27268052_Chip-Seq_Bcells_Human0.65043601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.63500116
2MP0003436_decreased_susceptibility_to3.92495668
3MP0003303_peritoneal_inflammation3.88049813
4MP0001835_abnormal_antigen_presentation3.74626569
5MP0002419_abnormal_innate_immunity3.33464675
6MP0009785_altered_susceptibility_to3.09389940
7MP0006082_CNS_inflammation2.94576612
8MP0005025_abnormal_response_to2.83642527
9MP0005000_abnormal_immune_tolerance2.61686253
10MP0001800_abnormal_humoral_immune2.47313613
11MP0002148_abnormal_hypersensitivity_rea2.43569515
12MP0008260_abnormal_autophagy2.43491954
13MP0003172_abnormal_lysosome_physiology2.41749371
14MP0002723_abnormal_immune_serum2.39884612
15MP0002452_abnormal_antigen_presenting2.34929930
16MP0000685_abnormal_immune_system2.32767428
17MP0000569_abnormal_digit_pigmentation2.26350877
18MP0002420_abnormal_adaptive_immunity2.25620598
19MP0009278_abnormal_bone_marrow2.25020193
20MP0009764_decreased_sensitivity_to2.23789168
21MP0001819_abnormal_immune_cell2.22957333
22MP0003191_abnormal_cellular_cholesterol2.20802881
23MP0005671_abnormal_response_to2.18243075
24MP0003828_pulmonary_edema2.12334033
25MP0005387_immune_system_phenotype2.10344282
26MP0001790_abnormal_immune_system2.10344282
27MP0001545_abnormal_hematopoietic_system2.02791132
28MP0005397_hematopoietic_system_phenotyp2.02791132
29MP0001533_abnormal_skeleton_physiology1.96625652
30MP0005451_abnormal_body_composition1.91540196
31MP0003300_gastrointestinal_ulcer1.81990333
32MP0003075_altered_response_to1.74229343
33MP0002132_abnormal_respiratory_system1.74113600
34MP0005464_abnormal_platelet_physiology1.73720613
35MP0001845_abnormal_inflammatory_respons1.73312545
36MP0000716_abnormal_immune_system1.64301576
37MP0004947_skin_inflammation1.62768386
38MP0005164_abnormal_response_to1.56495989
39MP0002405_respiratory_system_inflammati1.55871711
40MP0004883_abnormal_blood_vessel1.55299217
41MP0002398_abnormal_bone_marrow1.54371477
42MP0002396_abnormal_hematopoietic_system1.52020981
43MP0003656_abnormal_erythrocyte_physiolo1.50213700
44MP0008469_abnormal_protein_level1.49316367
45MP0004381_abnormal_hair_follicle1.44875009
46MP0010155_abnormal_intestine_physiology1.36946847
47MP0000858_altered_metastatic_potential1.35752165
48MP0002998_abnormal_bone_remodeling1.35109883
49MP0005058_abnormal_lysosome_morphology1.33606571
50MP0000465_gastrointestinal_hemorrhage1.30058367
51MP0002166_altered_tumor_susceptibility1.28570368
52MP0001853_heart_inflammation1.28299250
53MP0002722_abnormal_immune_system1.27034017
54MP0008004_abnormal_stomach_pH1.26776040
55MP0005310_abnormal_salivary_gland1.26670314
56MP0000689_abnormal_spleen_morphology1.26123380
57MP0002429_abnormal_blood_cell1.25620865
58MP0002277_abnormal_respiratory_mucosa1.24296665
59MP0005166_decreased_susceptibility_to1.24116743
60MP0002006_tumorigenesis1.22725871
61MP0004510_myositis1.20310284
62MP0002332_abnormal_exercise_endurance1.16231519
63MP0003763_abnormal_thymus_physiology1.14798621
64MP0003690_abnormal_glial_cell1.13832994
65MP0000015_abnormal_ear_pigmentation1.13013903
66MP0003011_delayed_dark_adaptation1.10100071
67MP0003866_abnormal_defecation1.05631019
68MP0005167_abnormal_blood-brain_barrier1.01309501
69MP0003448_altered_tumor_morphology0.99942725
70MP0000343_altered_response_to0.98929700
71MP0003806_abnormal_nucleotide_metabolis0.98402839
72MP0000604_amyloidosis0.96947538
73MP0003183_abnormal_peptide_metabolism0.95144882
74MP0004484_altered_response_of0.92723988
75MP0003787_abnormal_imprinting0.92492786
76MP0003221_abnormal_cardiomyocyte_apopto0.91639767
77MP0002009_preneoplasia0.89768451
78MP0003195_calcinosis0.89758539
79MP0000703_abnormal_thymus_morphology0.88786304
80MP0009763_increased_sensitivity_to0.88455514
81MP0004808_abnormal_hematopoietic_stem0.85509281
82MP0001851_eye_inflammation0.84851847
83MP0005376_homeostasis/metabolism_phenot0.84609002
84MP0009333_abnormal_splenocyte_physiolog0.84071555
85MP0009840_abnormal_foam_cell0.83733298
86MP0008877_abnormal_DNA_methylation0.83570449
87MP0005075_abnormal_melanosome_morpholog0.81532301
88MP0005390_skeleton_phenotype0.80336800
89MP0005174_abnormal_tail_pigmentation0.79866784
90MP0008874_decreased_physiological_sensi0.75196427
91MP0006054_spinal_hemorrhage0.68169449
92MP0000371_diluted_coat_color0.67589043
93MP0000249_abnormal_blood_vessel0.64388004
94MP0005266_abnormal_metabolism0.63007937
95MP0002693_abnormal_pancreas_physiology0.62280015
96MP0001501_abnormal_sleep_pattern0.61218174
97MP0001986_abnormal_taste_sensitivity0.61178051
98MP0005076_abnormal_cell_differentiation0.60035450
99MP0001663_abnormal_digestive_system0.58361734
100MP0003045_fibrosis0.57496598

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.15732856
2Optic neuritis (HP:0100653)5.99982779
3Retrobulbar optic neuritis (HP:0100654)5.99982779
4Recurrent abscess formation (HP:0002722)5.95004291
5Orchitis (HP:0100796)5.90650017
6Myositis (HP:0100614)5.82642240
7Eczematoid dermatitis (HP:0000976)5.71040488
8Stomatitis (HP:0010280)5.50584984
9Elevated erythrocyte sedimentation rate (HP:0003565)5.50424119
10Abnormality of macrophages (HP:0004311)5.28283754
11Recurrent gram-negative bacterial infections (HP:0005420)4.84984334
12Keratoconjunctivitis sicca (HP:0001097)4.34901344
13Mediastinal lymphadenopathy (HP:0100721)4.34019698
14Amyloidosis (HP:0011034)4.17477495
15Keratoconjunctivitis (HP:0001096)4.05912918
16Recurrent fungal infections (HP:0002841)4.01699146
17Recurrent skin infections (HP:0001581)4.01045183
18Obstructive lung disease (HP:0006536)3.92049571
19Chronic obstructive pulmonary disease (HP:0006510)3.92049571
20Recurrent cutaneous fungal infections (HP:0011370)3.74623329
21Chronic mucocutaneous candidiasis (HP:0002728)3.74623329
22Gastrointestinal infarctions (HP:0005244)3.70133517
23Hemoptysis (HP:0002105)3.66201047
24Meningitis (HP:0001287)3.64447695
25Spontaneous hematomas (HP:0007420)3.63645614
26Episodic fever (HP:0001954)3.58782059
27Gingivitis (HP:0000230)3.55074142
28Vasculitis (HP:0002633)3.52202954
29Encephalitis (HP:0002383)3.42513563
30Arterial thrombosis (HP:0004420)3.39644162
31Leukocytosis (HP:0001974)3.32627644
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.30366678
33Pulmonary infiltrates (HP:0002113)3.28505183
34Urticaria (HP:0001025)3.27030287
35Gangrene (HP:0100758)3.14797105
36Chest pain (HP:0100749)3.13327213
37Gingival bleeding (HP:0000225)3.11961683
38Peritonitis (HP:0002586)3.02690738
39Pulmonary embolism (HP:0002204)3.02052360
40Loss of speech (HP:0002371)2.89394652
41Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.84059877
42Increased IgE level (HP:0003212)2.79560309
43Granulocytopenia (HP:0001913)2.79501297
44Abnormality of T cell number (HP:0011839)2.75677885
45T lymphocytopenia (HP:0005403)2.74023530
46Thrombocytosis (HP:0001894)2.72625308
47Abnormality of the pleura (HP:0002103)2.63411895
48Anorexia (HP:0002039)2.62689053
49Prolonged bleeding time (HP:0003010)2.60840861
50Epistaxis (HP:0000421)2.60021267
51Eosinophilia (HP:0001880)2.58950734
52Polyneuropathy (HP:0001271)2.57256634
53Increased cerebral lipofuscin (HP:0011813)2.48354575
54Abnormality of liposaccharide metabolism (HP:0010968)2.47513124
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.47513124
56Abnormality of glycolipid metabolism (HP:0010969)2.47513124
57Recurrent viral infections (HP:0004429)2.46160088
58Petechiae (HP:0000967)2.44471974
59Autoimmune thrombocytopenia (HP:0001973)2.43505171
60Glomerulopathy (HP:0100820)2.42571239
61Sepsis (HP:0100806)2.39928596
62Vertigo (HP:0002321)2.38632622
63Abnormality of the endocardium (HP:0004306)2.38285936
64Osteomyelitis (HP:0002754)2.37621240
65Periodontitis (HP:0000704)2.31727817
66Cellulitis (HP:0100658)2.30706275
67Abnormality of T cells (HP:0002843)2.23561659
68Systemic lupus erythematosus (HP:0002725)2.15330355
69Acute hepatic failure (HP:0006554)2.11514089
70Thrombophlebitis (HP:0004418)2.10893428
71Increased IgM level (HP:0003496)2.10573606
72Hypergammaglobulinemia (HP:0010702)2.08241232
73Abnormality of the pericardium (HP:0001697)2.07529750
74Keratitis (HP:0000491)2.07412736
75Inflammation of the large intestine (HP:0002037)2.07091910
76Hematochezia (HP:0002573)2.03671594
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.02383125
78Cheilitis (HP:0100825)1.99079980
79Skin rash (HP:0000988)1.98979604
80Abnormality of the peritoneum (HP:0002585)1.98637227
81Abnormality of eosinophils (HP:0001879)1.98342156
82Amaurosis fugax (HP:0100576)1.95889373
83Myocardial infarction (HP:0001658)1.95549542
84Hepatosplenomegaly (HP:0001433)1.95454236
85Neoplasm of the tracheobronchial system (HP:0100552)1.92291969
86Fatigue (HP:0012378)1.91925866
87Skin ulcer (HP:0200042)1.90891369
88Subacute progressive viral hepatitis (HP:0006572)1.89223345
89Abnormality of T cell physiology (HP:0011840)1.88248045
90Gastrointestinal inflammation (HP:0004386)1.88157557
91Increased serum ferritin (HP:0003281)1.87976217
92Vacuolated lymphocytes (HP:0001922)1.84266440
93Acne (HP:0001061)1.83817430
94Increased CSF protein (HP:0002922)1.82871709
95Alveolar cell carcinoma (HP:0006519)1.82027190
96Purpura (HP:0000979)1.77571960
97Dysostosis multiplex (HP:0000943)1.76635971
98Disinhibition (HP:0000734)1.75803709
99Hypochromic anemia (HP:0001931)1.75065807
100Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74620553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.45253335
2IRAK43.41081128
3BLK3.33560956
4TYK23.07780280
5MAP2K32.97336251
6CSK2.40754747
7MAP4K12.34249559
8TNK22.22075448
9BMPR22.21513732
10MAP3K142.12755209
11FES2.04582690
12ZAP702.03395333
13MAP3K31.99965118
14IKBKE1.99126783
15TXK1.92426704
16FGR1.90111529
17IRAK11.87847718
18MAP3K61.87645096
19IRAK21.83870858
20JAK31.83125533
21TAOK31.80422264
22SIK31.71126684
23PIK3CG1.69424143
24ERN11.58961729
25IRAK31.56908603
26MAP3K111.56492397
27MAP3K11.49738559
28TBK11.49321733
29PRPF4B1.47634742
30HCK1.47577145
31SYK1.47444602
32TAOK11.46256127
33MATK1.45131032
34GRK61.43935153
35KIT1.43485640
36BTK1.43345477
37EPHB11.42990090
38JAK11.37812723
39MAP3K51.36695311
40JAK21.36176638
41KSR21.33427912
42LYN1.32310104
43TEC1.27380785
44IKBKB1.21193674
45MARK31.20984106
46GRK71.14104969
47CSF1R1.12272459
48MAP3K21.06205248
49MAP3K131.06157224
50MAP2K41.04650027
51RAF10.98316230
52LCK0.94637356
53ITK0.93097951
54MARK20.92866193
55YES10.88604542
56FRK0.84972789
57TESK20.82274191
58TAOK20.77816346
59TGFBR20.77292655
60ARAF0.75948148
61MAP2K60.73450935
62FGFR30.67658167
63DAPK20.67458434
64MOS0.67335200
65SIK20.67296210
66PIM20.65750366
67PDK10.64039218
68CDK190.63215290
69KSR10.62716481
70ACVR1B0.62672641
71PTK2B0.60809898
72LRRK20.57868679
73CDK60.57512782
74RET0.54646491
75DYRK1B0.53948502
76HIPK20.52956806
77PRKD20.51456363
78PIM10.50480228
79PDPK10.49882014
80STK100.47295423
81FYN0.44194297
82MAPK70.42013100
83MAP3K70.41986140
84WNK10.39236318
85STK110.38833786
86CHUK0.36050393
87EPHA30.35157034
88SIK10.34707034
89PRKCQ0.34562332
90ABL10.34320264
91RPS6KL10.32130920
92RPS6KC10.32130920
93RPS6KA60.30497424
94PRKD10.30242812
95CDK120.30077690
96STK240.29886688
97NLK0.26814412
98MAPKAPK20.25838695
99EGFR0.25603342
100SGK20.24795174

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.36205840
2Osteoclast differentiation_Homo sapiens_hsa043803.05360332
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.82354535
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.61644180
5Staphylococcus aureus infection_Homo sapiens_hsa051502.59516315
6Tuberculosis_Homo sapiens_hsa051522.47142156
7Legionellosis_Homo sapiens_hsa051342.44731520
8Malaria_Homo sapiens_hsa051442.21424352
9B cell receptor signaling pathway_Homo sapiens_hsa046622.03706202
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02303937
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.85913603
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.82552136
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78484406
14Measles_Homo sapiens_hsa051621.77561193
15Pertussis_Homo sapiens_hsa051331.71892151
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.70836186
17TNF signaling pathway_Homo sapiens_hsa046681.69689329
18Influenza A_Homo sapiens_hsa051641.68830593
19Hematopoietic cell lineage_Homo sapiens_hsa046401.67749751
20Graft-versus-host disease_Homo sapiens_hsa053321.66310544
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60937930
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57021835
23Toxoplasmosis_Homo sapiens_hsa051451.51694486
24Rheumatoid arthritis_Homo sapiens_hsa053231.50499763
25Chemokine signaling pathway_Homo sapiens_hsa040621.49890627
26Salmonella infection_Homo sapiens_hsa051321.44824445
27Allograft rejection_Homo sapiens_hsa053301.39511089
28Acute myeloid leukemia_Homo sapiens_hsa052211.39026803
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.36085896
30T cell receptor signaling pathway_Homo sapiens_hsa046601.35829580
31Phagosome_Homo sapiens_hsa041451.34889773
32African trypanosomiasis_Homo sapiens_hsa051431.32581299
33Hepatitis B_Homo sapiens_hsa051611.32211786
34Other glycan degradation_Homo sapiens_hsa005111.27783965
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24369843
36Herpes simplex infection_Homo sapiens_hsa051681.22488019
37Type I diabetes mellitus_Homo sapiens_hsa049401.21903089
38Dorso-ventral axis formation_Homo sapiens_hsa043201.19300889
39Autoimmune thyroid disease_Homo sapiens_hsa053201.16615294
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13534150
41Shigellosis_Homo sapiens_hsa051311.12616850
42Lysosome_Homo sapiens_hsa041421.11068989
43Non-small cell lung cancer_Homo sapiens_hsa052231.10200273
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07831800
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07158479
46Asthma_Homo sapiens_hsa053101.06816799
47Hepatitis C_Homo sapiens_hsa051601.05792206
48Pancreatic cancer_Homo sapiens_hsa052121.00921471
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97999264
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.96609621
51Amoebiasis_Homo sapiens_hsa051460.96273790
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91986497
53Chronic myeloid leukemia_Homo sapiens_hsa052200.90766327
54Primary immunodeficiency_Homo sapiens_hsa053400.90666541
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90533655
56Antigen processing and presentation_Homo sapiens_hsa046120.89817230
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88812362
58Prolactin signaling pathway_Homo sapiens_hsa049170.88762790
59Renal cell carcinoma_Homo sapiens_hsa052110.88695167
60VEGF signaling pathway_Homo sapiens_hsa043700.88231483
61Platelet activation_Homo sapiens_hsa046110.87831706
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.86912330
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.84987462
64Apoptosis_Homo sapiens_hsa042100.82129902
65FoxO signaling pathway_Homo sapiens_hsa040680.76130783
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76109602
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.74857525
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.73412104
69Type II diabetes mellitus_Homo sapiens_hsa049300.73368907
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73262296
71HIF-1 signaling pathway_Homo sapiens_hsa040660.70226878
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.68909644
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65985626
74Viral myocarditis_Homo sapiens_hsa054160.62085247
75Complement and coagulation cascades_Homo sapiens_hsa046100.61710715
76GnRH signaling pathway_Homo sapiens_hsa049120.61695324
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60718842
78Regulation of autophagy_Homo sapiens_hsa041400.60208988
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58824275
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54008869
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51733421
82Choline metabolism in cancer_Homo sapiens_hsa052310.50656048
83ErbB signaling pathway_Homo sapiens_hsa040120.50308897
84Insulin resistance_Homo sapiens_hsa049310.49717986
85mTOR signaling pathway_Homo sapiens_hsa041500.48456012
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44824556
87Notch signaling pathway_Homo sapiens_hsa043300.44794972
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.44103966
89Epstein-Barr virus infection_Homo sapiens_hsa051690.43479735
90Endocytosis_Homo sapiens_hsa041440.42324030
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.41184503
92MAPK signaling pathway_Homo sapiens_hsa040100.37092920
93Endometrial cancer_Homo sapiens_hsa052130.34256179
94Fatty acid biosynthesis_Homo sapiens_hsa000610.32763814
95Viral carcinogenesis_Homo sapiens_hsa052030.30888853
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30699024
97Collecting duct acid secretion_Homo sapiens_hsa049660.30382270
98Bladder cancer_Homo sapiens_hsa052190.30304165
99Colorectal cancer_Homo sapiens_hsa052100.29011299
100Inositol phosphate metabolism_Homo sapiens_hsa005620.28599225

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