GLYATL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.73299884
2drug catabolic process (GO:0042737)9.30623046
3glyoxylate metabolic process (GO:0046487)8.71431350
4epoxygenase P450 pathway (GO:0019373)8.46558188
5omega-hydroxylase P450 pathway (GO:0097267)8.19198159
6regulation of fibrinolysis (GO:0051917)7.86776162
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.75972708
8L-phenylalanine catabolic process (GO:0006559)7.75972708
9negative regulation of fibrinolysis (GO:0051918)7.64218752
10L-phenylalanine metabolic process (GO:0006558)7.02492659
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.02492659
12complement activation, alternative pathway (GO:0006957)6.96797841
13regulation of protein activation cascade (GO:2000257)6.77535436
14oxidative demethylation (GO:0070989)6.75524453
15cellular glucuronidation (GO:0052695)6.68800145
16urea metabolic process (GO:0019627)6.48025626
17fibrinolysis (GO:0042730)6.46766522
18uronic acid metabolic process (GO:0006063)6.37308643
19glucuronate metabolic process (GO:0019585)6.37308643
20drug metabolic process (GO:0017144)6.32788460
21serine family amino acid catabolic process (GO:0009071)6.32730556
22regulation of complement activation (GO:0030449)6.27319180
23bile acid biosynthetic process (GO:0006699)6.26745706
24ethanol oxidation (GO:0006069)6.19536503
25blood coagulation, intrinsic pathway (GO:0007597)6.04679778
26aromatic amino acid family catabolic process (GO:0009074)5.92063162
27nitrogen cycle metabolic process (GO:0071941)5.91411536
28glycine metabolic process (GO:0006544)5.90160358
29peptidyl-glutamic acid carboxylation (GO:0017187)5.83894716
30protein carboxylation (GO:0018214)5.83894716
31phenylpropanoid metabolic process (GO:0009698)5.73855238
32negative regulation of cholesterol transport (GO:0032375)5.66806739
33negative regulation of sterol transport (GO:0032372)5.66806739
34bile acid metabolic process (GO:0008206)5.55654714
35regulation of triglyceride catabolic process (GO:0010896)5.36924623
36urea cycle (GO:0000050)5.34296817
37S-adenosylmethionine metabolic process (GO:0046500)5.10438373
38ethanol metabolic process (GO:0006067)5.05252963
39bile acid and bile salt transport (GO:0015721)5.02417246
40amino-acid betaine metabolic process (GO:0006577)4.94534863
41regulation of plasminogen activation (GO:0010755)4.88377432
42negative regulation of hemostasis (GO:1900047)4.71856254
43negative regulation of blood coagulation (GO:0030195)4.71856254
44serine family amino acid metabolic process (GO:0009069)4.70470846
45triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.69145235
46alkaloid metabolic process (GO:0009820)4.64119678
47triglyceride homeostasis (GO:0070328)4.55847281
48acylglycerol homeostasis (GO:0055090)4.55847281
49protein activation cascade (GO:0072376)4.53278379
50tyrosine metabolic process (GO:0006570)4.50293718
51imidazole-containing compound metabolic process (GO:0052803)4.29335133
52indole-containing compound catabolic process (GO:0042436)4.28588011
53indolalkylamine catabolic process (GO:0046218)4.28588011
54tryptophan catabolic process (GO:0006569)4.28588011
55negative regulation of coagulation (GO:0050819)4.24590368
56negative regulation of wound healing (GO:0061045)4.21659377
57heme transport (GO:0015886)4.17922057
58alpha-amino acid catabolic process (GO:1901606)4.14850638
59arginine metabolic process (GO:0006525)4.11880148
60complement activation (GO:0006956)4.09089581
61serine family amino acid biosynthetic process (GO:0009070)4.07854403
62hormone catabolic process (GO:0042447)4.05973238
63response to mercury ion (GO:0046689)4.05255334
64complement activation, classical pathway (GO:0006958)4.01511597
65regulation of humoral immune response (GO:0002920)3.97542666
66negative regulation of protein activation cascade (GO:2000258)3.96868186
67negative regulation of lipase activity (GO:0060192)3.96030281
68aromatic amino acid family metabolic process (GO:0009072)3.95515423
69phospholipid efflux (GO:0033700)3.93114254
70cellular ketone body metabolic process (GO:0046950)3.91134771
71positive regulation of blood coagulation (GO:0030194)3.88940338
72positive regulation of hemostasis (GO:1900048)3.88940338
73fat-soluble vitamin biosynthetic process (GO:0042362)3.88650696
74amino acid salvage (GO:0043102)3.87781079
75L-methionine salvage (GO:0071267)3.87781079
76L-methionine biosynthetic process (GO:0071265)3.87781079
77acute-phase response (GO:0006953)3.80453872
78flavonoid metabolic process (GO:0009812)3.78449205
79high-density lipoprotein particle remodeling (GO:0034375)3.75664933
80plasma lipoprotein particle remodeling (GO:0034369)3.74520838
81protein-lipid complex remodeling (GO:0034368)3.74520838
82macromolecular complex remodeling (GO:0034367)3.74520838
83opsonization (GO:0008228)3.74513994
84xenobiotic metabolic process (GO:0006805)3.73614748
85drug transmembrane transport (GO:0006855)3.72427653
86cholesterol efflux (GO:0033344)3.70326775
87tryptophan metabolic process (GO:0006568)3.66561231
88polyketide metabolic process (GO:0030638)3.64836399
89doxorubicin metabolic process (GO:0044598)3.64836399
90daunorubicin metabolic process (GO:0044597)3.64836399
91cellular amino acid catabolic process (GO:0009063)3.63152523
92cytolysis (GO:0019835)3.60362761
93fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.59119816
94positive regulation of lipoprotein lipase activity (GO:0051006)3.59072160
95positive regulation of triglyceride lipase activity (GO:0061365)3.59072160
96intestinal cholesterol absorption (GO:0030299)3.58751237
97aminoglycoside antibiotic metabolic process (GO:0030647)3.58695788
98positive regulation of coagulation (GO:0050820)3.58558604
99sodium-independent organic anion transport (GO:0043252)3.58261741
100steroid catabolic process (GO:0006706)3.54683342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.02743319
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.48094009
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.59211062
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.78697344
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.51305674
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.24396591
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.99410544
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.85410475
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71128246
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.22642738
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51704392
12HTT_18923047_ChIP-ChIP_STHdh_Human2.27477142
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01967484
14IGF1R_20145208_ChIP-Seq_DFB_Human1.93625783
15GBX2_23144817_ChIP-Seq_PC3_Human1.92321168
16* HNF4A_19822575_ChIP-Seq_HepG2_Human1.91919775
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87644835
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83695496
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71671821
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.71547359
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.68641406
22* PIAS1_25552417_ChIP-Seq_VCAP_Human1.66985412
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.57763685
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57561629
25BCAT_22108803_ChIP-Seq_LS180_Human1.50706815
26TAF15_26573619_Chip-Seq_HEK293_Human1.43023774
27* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.41402937
28ER_23166858_ChIP-Seq_MCF-7_Human1.35245536
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.32175048
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.29787915
31AR_20517297_ChIP-Seq_VCAP_Human1.27360787
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27270511
33EZH2_22144423_ChIP-Seq_EOC_Human1.26147840
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24216064
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24099202
36* CBP_21632823_ChIP-Seq_H3396_Human1.21065390
37* IRF1_19129219_ChIP-ChIP_H3396_Human1.20354769
38PHF8_20622853_ChIP-Seq_HELA_Human1.17963292
39FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17724115
40* CBP_20019798_ChIP-Seq_JUKART_Human1.12955365
41* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12955365
42* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12234680
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12138753
44* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10898362
45* HNFA_21074721_ChIP-Seq_CACO-2_Human1.10124429
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09238041
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.07735924
48CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06960467
49NFYA_21822215_ChIP-Seq_K562_Human1.06595361
50* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06483419
51P300_19829295_ChIP-Seq_ESCs_Human1.05139362
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04794185
53ZNF274_21170338_ChIP-Seq_K562_Hela1.03983614
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03246596
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03242579
56CDX2_22108803_ChIP-Seq_LS180_Human1.02894527
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02478040
58STAT3_23295773_ChIP-Seq_U87_Human1.01718127
59VDR_22108803_ChIP-Seq_LS180_Human1.00783601
60SOX2_19829295_ChIP-Seq_ESCs_Human1.00514838
61NANOG_19829295_ChIP-Seq_ESCs_Human1.00514838
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00259979
63CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98572294
64* TCF4_23295773_ChIP-Seq_U87_Human0.97906698
65ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97707796
66FOXA1_25552417_ChIP-Seq_VCAP_Human0.97633206
67* TCF4_22108803_ChIP-Seq_LS180_Human0.96729403
68SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94578733
69SMAD4_21799915_ChIP-Seq_A2780_Human0.94440583
70AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93311600
71NFYB_21822215_ChIP-Seq_K562_Human0.92455662
72FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92344016
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92013153
74AR_25329375_ChIP-Seq_VCAP_Human0.91771021
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90925585
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90520031
77CBX2_22325352_ChIP-Seq_293T-Rex_Human0.90004688
78OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88330036
79SMAD4_21741376_ChIP-Seq_EPCs_Human0.88289250
80GATA6_21074721_ChIP-Seq_CACO-2_Human0.88237731
81ETV1_20927104_ChIP-Seq_GIST48_Human0.87985422
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87197839
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.87197839
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86837978
85GATA4_25053715_ChIP-Seq_YYC3_Human0.85565309
86ERG_20517297_ChIP-Seq_VCAP_Human0.85500765
87NCOR_22424771_ChIP-Seq_293T_Human0.84727806
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84309280
89CEBPB_22108803_ChIP-Seq_LS180_Human0.84057057
90KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83327558
91TP53_18474530_ChIP-ChIP_U2OS_Human0.82403729
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.82046295
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81843980
94* RUNX2_22187159_ChIP-Seq_PCA_Human0.81670768
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81239670
96* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79801412
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.78550814
98RBPJ_21746931_ChIP-Seq_IB4_Human0.78272197
99OCT4_18555785_Chip-Seq_ESCs_Mouse0.77998716
100AR_21909140_ChIP-Seq_LNCAP_Human0.77299557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.74779806
2MP0005085_abnormal_gallbladder_physiolo6.12929648
3MP0005360_urolithiasis6.08591345
4MP0003195_calcinosis5.57356646
5MP0008875_abnormal_xenobiotic_pharmacok5.48320200
6MP0005365_abnormal_bile_salt5.44069934
7MP0002138_abnormal_hepatobiliary_system4.78846948
8MP0003252_abnormal_bile_duct4.28624506
9MP0003868_abnormal_feces_composition3.51848647
10MP0001666_abnormal_nutrient_absorption3.21579616
11MP0009697_abnormal_copulation3.18979245
12MP0010329_abnormal_lipoprotein_level2.51382305
13MP0005332_abnormal_amino_acid2.37239027
14MP0002876_abnormal_thyroid_physiology2.19717761
15MP0003806_abnormal_nucleotide_metabolis2.01220459
16MP0001764_abnormal_homeostasis1.87746570
17MP0009840_abnormal_foam_cell1.75709789
18MP0003718_maternal_effect1.67836316
19MP0002118_abnormal_lipid_homeostasis1.57953868
20MP0000609_abnormal_liver_physiology1.57919790
21MP0004019_abnormal_vitamin_homeostasis1.44923067
22MP0003191_abnormal_cellular_cholesterol1.39570247
23MP0005395_other_phenotype1.39030368
24MP0010368_abnormal_lymphatic_system1.19069646
25MP0005408_hypopigmentation1.13910006
26MP0005319_abnormal_enzyme/_coenzyme1.12582940
27MP0003186_abnormal_redox_activity1.02318705
28MP0005187_abnormal_penis_morphology1.01371880
29MP0009643_abnormal_urine_homeostasis1.01114518
30MP0005670_abnormal_white_adipose0.96956584
31MP0003011_delayed_dark_adaptation0.96348462
32MP0008872_abnormal_physiological_respon0.94383760
33MP0004043_abnormal_pH_regulation0.94044712
34MP0000598_abnormal_liver_morphology0.92862616
35MP0009053_abnormal_anal_canal0.92698615
36MP0006292_abnormal_olfactory_placode0.89731430
37MP0003656_abnormal_erythrocyte_physiolo0.89354918
38MP0005636_abnormal_mineral_homeostasis0.89188482
39MP0003879_abnormal_hair_cell0.88522341
40MP0002168_other_aberrant_phenotype0.87706532
41MP0005584_abnormal_enzyme/coenzyme_acti0.82910943
42MP0001661_extended_life_span0.82598480
43MP0002132_abnormal_respiratory_system0.80613801
44MP0005647_abnormal_sex_gland0.77564936
45MP0009642_abnormal_blood_homeostasis0.77219236
46MP0005376_homeostasis/metabolism_phenot0.76976726
47MP0002282_abnormal_trachea_morphology0.70194528
48MP0009763_increased_sensitivity_to0.66189881
49MP0005646_abnormal_pituitary_gland0.66097118
50MP0005266_abnormal_metabolism0.63112252
51MP0001756_abnormal_urination0.57256125
52MP0003638_abnormal_response/metabolism_0.56408616
53MP0009764_decreased_sensitivity_to0.56396282
54MP0005535_abnormal_body_temperature0.54666963
55MP0005464_abnormal_platelet_physiology0.54398406
56MP0000566_synostosis0.54362247
57MP0005551_abnormal_eye_electrophysiolog0.53839721
58MP0001915_intracranial_hemorrhage0.52605511
59MP0002078_abnormal_glucose_homeostasis0.52397112
60MP0006036_abnormal_mitochondrial_physio0.49640197
61MP0008469_abnormal_protein_level0.49422534
62MP0002971_abnormal_brown_adipose0.48725407
63MP0002928_abnormal_bile_duct0.46984409
64MP0002090_abnormal_vision0.46141814
65MP0002249_abnormal_larynx_morphology0.42175615
66MP0008874_decreased_physiological_sensi0.41735761
67MP0002234_abnormal_pharynx_morphology0.40196951
68MP0005220_abnormal_exocrine_pancreas0.39667953
69MP0005334_abnormal_fat_pad0.39088472
70MP0002136_abnormal_kidney_physiology0.37447413
71MP0003699_abnormal_female_reproductive0.37133626
72MP0004142_abnormal_muscle_tone0.34786044
73MP0000604_amyloidosis0.32663228
74MP0005410_abnormal_fertilization0.32461837
75MP0001984_abnormal_olfaction0.32206807
76MP0009765_abnormal_xenobiotic_induced0.30716263
77MP0003959_abnormal_lean_body0.30641114
78MP0006035_abnormal_mitochondrial_morpho0.30304846
79MP0008877_abnormal_DNA_methylation0.30141314
80MP0003953_abnormal_hormone_level0.29794787
81MP0003941_abnormal_skin_development0.29629598
82MP0008789_abnormal_olfactory_epithelium0.29582083
83MP0005084_abnormal_gallbladder_morpholo0.29331200
84MP0005451_abnormal_body_composition0.25605579
85MP0001929_abnormal_gametogenesis0.25518660
86MP0001293_anophthalmia0.25357638
87MP0008873_increased_physiological_sensi0.24551246
88MP0002736_abnormal_nociception_after0.24394594
89MP0003890_abnormal_embryonic-extraembry0.23803953
90MP0005499_abnormal_olfactory_system0.23495906
91MP0005394_taste/olfaction_phenotype0.23495906
92MP0003690_abnormal_glial_cell0.23207845
93MP0002161_abnormal_fertility/fecundity0.22454429
94MP0001986_abnormal_taste_sensitivity0.21237530
95MP0002069_abnormal_eating/drinking_beha0.21015789
96MP0001324_abnormal_eye_pigmentation0.20714463
97MP0010386_abnormal_urinary_bladder0.20569661
98MP0002697_abnormal_eye_size0.19814084
99MP0000653_abnormal_sex_gland0.19748162
100MP0005448_abnormal_energy_balance0.19259842

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.18757852
2Prolonged partial thromboplastin time (HP:0003645)8.61787750
3Complement deficiency (HP:0004431)7.97669032
4Abnormality of aromatic amino acid family metabolism (HP:0004338)7.89748770
5Hypobetalipoproteinemia (HP:0003563)7.45396609
6Conjugated hyperbilirubinemia (HP:0002908)6.50044257
7Abnormality of complement system (HP:0005339)6.24545281
8Hyperlipoproteinemia (HP:0010980)5.66685970
9Intrahepatic cholestasis (HP:0001406)5.63072844
10Joint hemorrhage (HP:0005261)5.62573168
11Systemic lupus erythematosus (HP:0002725)4.99024091
12Abnormality of pyrimidine metabolism (HP:0004353)4.84283343
13Xanthomatosis (HP:0000991)4.36642072
14Hyperglycinemia (HP:0002154)4.26420883
15Glomerulonephritis (HP:0000099)4.20689216
16Abnormality of the common coagulation pathway (HP:0010990)4.10605246
17Spontaneous abortion (HP:0005268)4.09161777
18Hypolipoproteinemia (HP:0010981)4.08965540
19Generalized aminoaciduria (HP:0002909)4.01860159
20Abnormality of the intrinsic pathway (HP:0010989)3.79524281
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.78609777
22Abnormality of serine family amino acid metabolism (HP:0010894)3.67252505
23Abnormality of glycine metabolism (HP:0010895)3.67252505
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.53102234
25Abnormality of methionine metabolism (HP:0010901)3.48302245
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.44870047
27Recurrent gram-negative bacterial infections (HP:0005420)3.43415490
28Hyperglycinuria (HP:0003108)3.39759448
29Fat malabsorption (HP:0002630)3.38519898
30Abnormality of serum amino acid levels (HP:0003112)3.31231669
31Hyperammonemia (HP:0001987)3.27544644
32Rickets (HP:0002748)3.24652808
33Delayed CNS myelination (HP:0002188)3.20208827
34Nephritis (HP:0000123)3.19371693
35Fair hair (HP:0002286)3.17067568
36Osteomalacia (HP:0002749)3.15691477
37Epidermoid cyst (HP:0200040)2.80981617
38Steatorrhea (HP:0002570)2.80849391
39Abnormality of nucleobase metabolism (HP:0010932)2.80019322
40Reduced antithrombin III activity (HP:0001976)2.76155322
41Cholecystitis (HP:0001082)2.73985628
42Abnormal gallbladder physiology (HP:0012438)2.73985628
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.69846255
44Gingival bleeding (HP:0000225)2.61204171
45Abnormality of urine glucose concentration (HP:0011016)2.51945902
46Glycosuria (HP:0003076)2.51945902
47Hyperbilirubinemia (HP:0002904)2.50958107
48Hypoalphalipoproteinemia (HP:0003233)2.50081144
49Hyperphosphaturia (HP:0003109)2.49715716
50Abnormal biliary tract physiology (HP:0012439)2.45043747
51Bile duct proliferation (HP:0001408)2.45043747
52Neonatal hypoglycemia (HP:0001998)2.44862852
53Hypophosphatemic rickets (HP:0004912)2.41111163
54Hypercholesterolemia (HP:0003124)2.40146515
55Bifid scrotum (HP:0000048)2.38218667
56Vascular calcification (HP:0004934)2.36427508
57Abnormality of vitamin metabolism (HP:0100508)2.34601893
58Metabolic acidosis (HP:0001942)2.33620743
59Menorrhagia (HP:0000132)2.31467828
60Ketosis (HP:0001946)2.26753358
61Generalized hypopigmentation of hair (HP:0011358)2.18997233
62Proximal tubulopathy (HP:0000114)2.17818895
63Increased mean platelet volume (HP:0011877)2.16117772
64Alkalosis (HP:0001948)2.15437707
65Thrombophlebitis (HP:0004418)2.13985315
66Purpura (HP:0000979)2.12992372
67Hemorrhage of the eye (HP:0011885)2.12420029
68Elevated alkaline phosphatase (HP:0003155)2.10184917
69Irritability (HP:0000737)2.08083521
70Abnormal urine phosphate concentration (HP:0012599)2.07040361
71Cholelithiasis (HP:0001081)2.02361958
72Abnormality of fatty-acid metabolism (HP:0004359)2.00474233
73Abnormality of monocarboxylic acid metabolism (HP:0010996)10.0304127
74Cardiovascular calcification (HP:0011915)1.99184226
75Abnormal gallbladder morphology (HP:0012437)1.97165863
76Abnormal enzyme/coenzyme activity (HP:0012379)1.93611316
77Hypochromic microcytic anemia (HP:0004840)1.92815763
78Mitral stenosis (HP:0001718)1.92048085
79Hepatocellular carcinoma (HP:0001402)1.91341000
80Azoospermia (HP:0000027)1.90178522
81Abnormality of alkaline phosphatase activity (HP:0004379)1.89331477
82Abnormal platelet volume (HP:0011876)1.87012517
83Abnormality of purine metabolism (HP:0004352)1.86398312
84Lethargy (HP:0001254)1.85836977
85Pulmonary embolism (HP:0002204)1.85351206
86Arthropathy (HP:0003040)1.82389992
87Poikilocytosis (HP:0004447)1.78600161
88Sensorimotor neuropathy (HP:0007141)1.74501983
89Hypoglycemic coma (HP:0001325)1.64717088
90Gout (HP:0001997)1.63965873
91Enlarged kidneys (HP:0000105)1.61241917
92Abnormal platelet function (HP:0011869)1.55529406
93Impaired platelet aggregation (HP:0003540)1.55529406
94Cerebral edema (HP:0002181)1.54882106
95Increased circulating renin level (HP:0000848)1.53124739
96Abnormality of transition element cation homeostasis (HP:0011030)1.51854986
97Abnormality of iron homeostasis (HP:0011031)1.51452553
98Increased serum pyruvate (HP:0003542)1.50475216
99Abnormal tarsal ossification (HP:0008369)1.48316418
100Impulsivity (HP:0100710)1.47106591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.99453154
2PIK3CG3.29084127
3OXSR12.98700628
4FRK2.85408262
5BRSK22.44776047
6TNK22.34036863
7AKT32.31517803
8TRIM282.25157569
9NUAK12.22127897
10EIF2AK32.15927721
11TAOK32.02611452
12ZAK2.00851038
13BCKDK1.91780788
14FER1.87323874
15INSRR1.69305588
16CASK1.63615363
17BMPR1B1.59482624
18MAP4K21.57017831
19EIF2AK11.52030339
20GRK11.48682682
21MAPK131.39623999
22STK391.34691143
23PRKACG1.34589271
24MST41.32238840
25PRKCG1.30827476
26STK38L1.30318823
27SGK21.28376658
28PAK31.22794369
29PRKD31.22065140
30PINK11.20708200
31BCR1.18270526
32PIK3CA1.17892903
33EPHA41.13640916
34NTRK31.13167355
35LATS11.12000651
36ACVR1B1.11502491
37NEK11.10020991
38CSNK1G11.05309053
39CDC71.04627861
40PRKAA21.04226968
41CAMK1D1.03009613
42TTK1.01110931
43MAP3K41.00076705
44MYLK0.98305996
45EPHA30.96007394
46NLK0.95725190
47CAMK1G0.94650375
48TNIK0.94496302
49PBK0.94116023
50DYRK20.88459267
51PRKCZ0.87820666
52IGF1R0.87305583
53ERBB30.86848475
54SGK2230.85708501
55SGK4940.85708501
56CSNK1D0.85374705
57WNK40.84984695
58MAP3K120.84289005
59NEK90.82883652
60PRKG10.82368407
61MAP3K50.79130079
62WEE10.77018200
63ADRBK20.76907788
64PRKACA0.73546405
65MAP2K40.72681304
66CSNK1E0.69862820
67VRK10.65905310
68PRKAA10.64294092
69PLK30.63585032
70ARAF0.62371790
71PRKCE0.61325614
72PRKCI0.59965593
73SGK30.58077441
74CSNK1G30.57226638
75MAP3K90.57119077
76PLK10.54740033
77NEK60.52853813
78TIE10.52463442
79CSNK1A10.50529962
80CDK90.50401803
81AURKA0.50336582
82PLK40.48667925
83CSNK1A1L0.47347082
84PRKCB0.47159691
85CDK70.46993286
86PRKCA0.46766522
87ATM0.43891892
88CSNK1G20.43689173
89PRKACB0.43218954
90ERBB20.43106334
91STK30.42735562
92BRSK10.40578230
93STK160.37519109
94TAF10.35395750
95MAP2K70.34655490
96MET0.33392329
97PKN10.32103674
98MARK10.31825729
99RPS6KA30.31739205
100MELK0.31415732

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.69002475
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.05590077
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.76773955
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.49394275
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.38634619
6Retinol metabolism_Homo sapiens_hsa008303.37531513
7Complement and coagulation cascades_Homo sapiens_hsa046103.26909547
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.93112360
9Chemical carcinogenesis_Homo sapiens_hsa052042.87138801
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.83943232
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.73136957
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.64722729
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.53552128
14Butanoate metabolism_Homo sapiens_hsa006502.39089618
15Fatty acid degradation_Homo sapiens_hsa000712.38472375
16Phenylalanine metabolism_Homo sapiens_hsa003602.33658764
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24773709
18Arginine biosynthesis_Homo sapiens_hsa002202.24456092
19Tyrosine metabolism_Homo sapiens_hsa003502.06555279
20Tryptophan metabolism_Homo sapiens_hsa003801.93179810
21Linoleic acid metabolism_Homo sapiens_hsa005911.87565868
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82483523
23Histidine metabolism_Homo sapiens_hsa003401.81029146
24Bile secretion_Homo sapiens_hsa049761.77095985
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.69306223
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56055851
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.51971043
28beta-Alanine metabolism_Homo sapiens_hsa004101.45722058
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44671386
30Starch and sucrose metabolism_Homo sapiens_hsa005001.42188264
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.41725319
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40210764
33Peroxisome_Homo sapiens_hsa041461.39693321
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32488254
35Propanoate metabolism_Homo sapiens_hsa006401.30819468
36Vitamin B6 metabolism_Homo sapiens_hsa007501.22805248
37Pyruvate metabolism_Homo sapiens_hsa006201.22392848
38PPAR signaling pathway_Homo sapiens_hsa033201.21651329
39Arachidonic acid metabolism_Homo sapiens_hsa005901.11816420
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08861253
41Arginine and proline metabolism_Homo sapiens_hsa003301.05277353
42Biosynthesis of amino acids_Homo sapiens_hsa012301.00727522
43One carbon pool by folate_Homo sapiens_hsa006700.92848652
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86926131
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85988738
46Fatty acid metabolism_Homo sapiens_hsa012120.85035487
47Carbon metabolism_Homo sapiens_hsa012000.83024509
48Staphylococcus aureus infection_Homo sapiens_hsa051500.80599680
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80109703
50ABC transporters_Homo sapiens_hsa020100.73940757
51Fat digestion and absorption_Homo sapiens_hsa049750.72239652
52Prion diseases_Homo sapiens_hsa050200.70479463
53Lysine degradation_Homo sapiens_hsa003100.70254792
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67303544
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56042729
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.49305278
57Metabolic pathways_Homo sapiens_hsa011000.49204777
58Sulfur metabolism_Homo sapiens_hsa009200.48010575
59Fatty acid elongation_Homo sapiens_hsa000620.47020788
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36946994
61Steroid biosynthesis_Homo sapiens_hsa001000.35930007
62Sulfur relay system_Homo sapiens_hsa041220.35409369
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34370566
64Glycerolipid metabolism_Homo sapiens_hsa005610.28117899
65Selenocompound metabolism_Homo sapiens_hsa004500.21083998
66Vitamin digestion and absorption_Homo sapiens_hsa049770.19320912
67Glutathione metabolism_Homo sapiens_hsa004800.17505253
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16222863
69Serotonergic synapse_Homo sapiens_hsa047260.12282055
70Pentose phosphate pathway_Homo sapiens_hsa000300.08035129
71Insulin resistance_Homo sapiens_hsa049310.07227291
72Fructose and mannose metabolism_Homo sapiens_hsa000510.06770225
73Glucagon signaling pathway_Homo sapiens_hsa049220.06638287
74Fatty acid biosynthesis_Homo sapiens_hsa000610.05150414
75Systemic lupus erythematosus_Homo sapiens_hsa053220.00378893
76Amoebiasis_Homo sapiens_hsa05146-0.2381909
77Non-homologous end-joining_Homo sapiens_hsa03450-0.2271378
78Base excision repair_Homo sapiens_hsa03410-0.2197877
79Galactose metabolism_Homo sapiens_hsa00052-0.2038480
80Pyrimidine metabolism_Homo sapiens_hsa00240-0.1977997
81Homologous recombination_Homo sapiens_hsa03440-0.1886756
82Fanconi anemia pathway_Homo sapiens_hsa03460-0.1879626
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1798096
84Basal transcription factors_Homo sapiens_hsa03022-0.1530434
85Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.1415047
86Sphingolipid metabolism_Homo sapiens_hsa00600-0.1407291
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1333058
88Ether lipid metabolism_Homo sapiens_hsa00565-0.1220028
89Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1191743
90Circadian rhythm_Homo sapiens_hsa04710-0.1012486
91Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0934233
92Mismatch repair_Homo sapiens_hsa03430-0.0731638
93AMPK signaling pathway_Homo sapiens_hsa04152-0.0655878
94Phototransduction_Homo sapiens_hsa04744-0.0647704
95Renin-angiotensin system_Homo sapiens_hsa04614-0.0492261
96Mineral absorption_Homo sapiens_hsa04978-0.0280186
97Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0097811
98Nitrogen metabolism_Homo sapiens_hsa00910-0.0090735
99Pertussis_Homo sapiens_hsa05133-0.0055556
100Folate biosynthesis_Homo sapiens_hsa00790-0.0043731

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