GLYATL1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)9.54838120
2thrombin receptor signaling pathway (GO:0070493)8.34291087
3neutrophil activation involved in immune response (GO:0002283)6.70734028
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.99551264
5regulation of integrin-mediated signaling pathway (GO:2001044)5.75588395
6blood coagulation, intrinsic pathway (GO:0007597)5.66639683
7regulation of platelet aggregation (GO:0090330)5.57967910
8regulation of platelet activation (GO:0010543)5.50502452
9negative regulation of norepinephrine secretion (GO:0010700)5.32833384
10adenosine receptor signaling pathway (GO:0001973)5.27474955
11negative regulation of thymocyte apoptotic process (GO:0070244)4.92898274
12leukocyte migration involved in inflammatory response (GO:0002523)4.88252181
13platelet aggregation (GO:0070527)4.79647382
14regulation of Golgi to plasma membrane protein transport (GO:0042996)4.73941811
15G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.56186464
16low-density lipoprotein particle remodeling (GO:0034374)4.55551183
17purinergic nucleotide receptor signaling pathway (GO:0035590)4.55292463
18negative regulation of heart rate (GO:0010459)4.54428161
19negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.51748865
20negative regulation of platelet activation (GO:0010544)4.47829566
21negative regulation of protein localization to cell surface (GO:2000009)4.40069358
22regulation of lipoprotein metabolic process (GO:0050746)4.34108550
23positive regulation of mast cell activation (GO:0033005)4.14226031
24positive regulation of endothelial cell differentiation (GO:0045603)4.13244157
25negative regulation of appetite (GO:0032099)4.06152453
26negative regulation of response to food (GO:0032096)4.06152453
27positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.04430670
28angiogenesis involved in wound healing (GO:0060055)4.04361978
29neutrophil activation (GO:0042119)4.01061156
30negative regulation of T-helper cell differentiation (GO:0045623)3.97553494
31negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.97553494
32negative regulation of homotypic cell-cell adhesion (GO:0034111)3.95043853
33megakaryocyte development (GO:0035855)3.94084644
34positive regulation of cAMP-mediated signaling (GO:0043950)3.90725930
35lipoxygenase pathway (GO:0019372)3.88232599
36beta-amyloid metabolic process (GO:0050435)3.86901184
37fatty acid elongation (GO:0030497)3.86539608
38microtubule depolymerization (GO:0007019)3.68212593
39regulation of norepinephrine secretion (GO:0014061)3.67506874
40regulation of female receptivity (GO:0045924)3.65033445
41purinergic receptor signaling pathway (GO:0035587)3.62291442
42high-density lipoprotein particle remodeling (GO:0034375)3.58573276
43platelet degranulation (GO:0002576)3.51169872
44positive regulation of protein homodimerization activity (GO:0090073)3.47401967
45fusion of sperm to egg plasma membrane (GO:0007342)3.47293157
46long-chain fatty acid biosynthetic process (GO:0042759)3.46797339
47negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.43894370
48reverse cholesterol transport (GO:0043691)3.40124608
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.39265598
50regulation of integrin activation (GO:0033623)3.38875357
51positive regulation of Rho protein signal transduction (GO:0035025)3.38379610
52polyamine biosynthetic process (GO:0006596)3.37313795
53granulocyte activation (GO:0036230)3.37253845
54dopamine transport (GO:0015872)3.35467528
55adenosine metabolic process (GO:0046085)3.35428040
56regulation of macrophage derived foam cell differentiation (GO:0010743)3.34840860
57platelet formation (GO:0030220)3.28918292
58negative regulation of catecholamine secretion (GO:0033604)3.28598696
59monoamine transport (GO:0015844)3.28472520
60positive regulation of macrophage differentiation (GO:0045651)3.28448905
61negative regulation of calcium ion transport into cytosol (GO:0010523)3.26700119
62autophagic vacuole fusion (GO:0000046)3.25889977
63phospholipid homeostasis (GO:0055091)3.24043969
64negative regulation of neural precursor cell proliferation (GO:2000178)3.22179085
65platelet activation (GO:0030168)3.21683923
66homotypic cell-cell adhesion (GO:0034109)3.21324355
67negative regulation of alpha-beta T cell differentiation (GO:0046639)3.20969885
68positive regulation of systemic arterial blood pressure (GO:0003084)3.20135388
69regulation of MHC class II biosynthetic process (GO:0045346)3.19745870
70regulation of memory T cell differentiation (GO:0043380)3.17351210
71G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.16349681
72regulation of glutamate secretion (GO:0014048)3.15491510
73positive regulation of granulocyte differentiation (GO:0030854)3.12557368
74negative regulation of heart contraction (GO:0045822)3.10902357
75positive regulation of hemostasis (GO:1900048)3.10399535
76positive regulation of blood coagulation (GO:0030194)3.10399535
77termination of G-protein coupled receptor signaling pathway (GO:0038032)3.04932422
78female mating behavior (GO:0060180)3.03810454
79positive regulation of amino acid transport (GO:0051957)3.01400577
80sequestering of actin monomers (GO:0042989)2.99070168
81regulation of homotypic cell-cell adhesion (GO:0034110)2.97681722
82mitochondrial calcium ion homeostasis (GO:0051560)2.89190984
83positive regulation of receptor recycling (GO:0001921)2.88364696
84regulation of T-helper 1 cell differentiation (GO:0045625)2.87939575
85positive regulation of coagulation (GO:0050820)2.86070897
86termination of signal transduction (GO:0023021)2.86042800
87negative regulation of T cell apoptotic process (GO:0070233)2.85283046
88cellular biogenic amine biosynthetic process (GO:0042401)2.83677582
89mitochondrial calcium ion transport (GO:0006851)2.83077157
90regulation of endothelial cell differentiation (GO:0045601)2.82954423
91negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.81608581
92endothelium development (GO:0003158)2.79621344
93peptide catabolic process (GO:0043171)2.78773161
94regulation of cholesterol efflux (GO:0010874)2.77154649
95regulation of mitochondrial depolarization (GO:0051900)2.76338758
96regulation of megakaryocyte differentiation (GO:0045652)2.76327104
97regulation of hemostasis (GO:1900046)2.76139169
98regulation of blood coagulation (GO:0030193)2.76139169
99pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75744073
100negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.75284209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.95226217
2GBX2_23144817_ChIP-Seq_PC3_Human3.69427855
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.64603229
4SCL_19346495_ChIP-Seq_HPC-7_Human3.38702749
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.99978618
6EZH2_22144423_ChIP-Seq_EOC_Human2.92886806
7GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.63376732
8TAF15_26573619_Chip-Seq_HEK293_Human2.56639176
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55785910
10IGF1R_20145208_ChIP-Seq_DFB_Human2.54002056
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42601680
12VDR_22108803_ChIP-Seq_LS180_Human2.34469294
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19402732
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17215266
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16058329
16GATA1_19941826_ChIP-Seq_K562_Human2.15929766
17EWS_26573619_Chip-Seq_HEK293_Human2.14964326
18LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.07436412
19HTT_18923047_ChIP-ChIP_STHdh_Human2.02797072
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01680804
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.94202728
22GATA2_19941826_ChIP-Seq_K562_Human1.93768074
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92770938
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92436729
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82840325
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76786827
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.75591304
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.73317813
29GATA1_19941827_ChIP-Seq_MEL_Mouse1.69649498
30P300_19829295_ChIP-Seq_ESCs_Human1.68258477
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63271991
32IRF1_19129219_ChIP-ChIP_H3396_Human1.60754786
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59488677
34SMAD4_21799915_ChIP-Seq_A2780_Human1.56488727
35AR_25329375_ChIP-Seq_VCAP_Human1.53271326
36SALL4_22934838_ChIP-ChIP_CD34+_Human1.49532316
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49404095
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47031590
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46773025
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44900027
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44330680
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42519411
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40432433
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.40307834
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.38909550
46BCAT_22108803_ChIP-Seq_LS180_Human1.38345364
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37415259
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37415259
49SPI1_23127762_ChIP-Seq_K562_Human1.34382842
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32338678
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30445814
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30014969
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29883304
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29729143
55ER_23166858_ChIP-Seq_MCF-7_Human1.29282325
56TCF4_23295773_ChIP-Seq_U87_Human1.26169789
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22492966
58GATA1_22025678_ChIP-Seq_K562_Human1.19716792
59GATA1_19941827_ChIP-Seq_MEL86_Mouse1.18549229
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18172867
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17614789
62NANOG_19829295_ChIP-Seq_ESCs_Human1.17579518
63SOX2_19829295_ChIP-Seq_ESCs_Human1.17579518
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.17111097
65P53_22387025_ChIP-Seq_ESCs_Mouse1.16824245
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.15020886
67STAT3_23295773_ChIP-Seq_U87_Human1.13259344
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12304690
69KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10952157
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.10151674
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10022378
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09097578
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06204785
74AR_20517297_ChIP-Seq_VCAP_Human1.05178184
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04480568
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.04125440
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03670760
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03272243
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.03242434
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02740478
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02486435
82RNF2_27304074_Chip-Seq_NSC_Mouse1.02092401
83OCT1_27270436_Chip-Seq_PROSTATE_Human1.02032836
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.01838346
85FUS_26573619_Chip-Seq_HEK293_Human1.00175663
86LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99587797
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99331655
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98339881
89NANOG_18555785_Chip-Seq_ESCs_Mouse0.97995543
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95890894
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95890894
92IRF8_27001747_Chip-Seq_BMDM_Mouse0.95750249
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94719510
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94551026
95WT1_19549856_ChIP-ChIP_CCG9911_Human0.94090840
96JUN_21703547_ChIP-Seq_K562_Human0.93437301
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.92686114
98TCF4_22108803_ChIP-Seq_LS180_Human0.91534092
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90116851
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89786773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.45168054
2MP0008004_abnormal_stomach_pH5.24875347
3MP0000465_gastrointestinal_hemorrhage4.02334195
4MP0003724_increased_susceptibility_to3.38507715
5MP0002736_abnormal_nociception_after3.35489566
6MP0005646_abnormal_pituitary_gland2.93820204
7MP0009697_abnormal_copulation2.65892637
8MP0008872_abnormal_physiological_respon2.50940286
9MP0000230_abnormal_systemic_arterial2.25522812
10MP0001968_abnormal_touch/_nociception2.20316896
11MP0001835_abnormal_antigen_presentation2.17310321
12MP0005084_abnormal_gallbladder_morpholo2.05964159
13MP0005410_abnormal_fertilization2.03870474
14MP0004084_abnormal_cardiac_muscle2.02827966
15MP0004510_myositis2.01935701
16MP0008775_abnormal_heart_ventricle2.01671416
17MP0000343_altered_response_to1.89795868
18MP0005167_abnormal_blood-brain_barrier1.89169892
19MP0005083_abnormal_biliary_tract1.88286677
20MP0003638_abnormal_response/metabolism_1.72386947
21MP0009780_abnormal_chondrocyte_physiolo1.69774759
22MP0003718_maternal_effect1.64415414
23MP0010329_abnormal_lipoprotein_level1.40545186
24MP0004215_abnormal_myocardial_fiber1.37746454
25MP0010155_abnormal_intestine_physiology1.33970670
26MP0001879_abnormal_lymphatic_vessel1.33958285
27MP0002733_abnormal_thermal_nociception1.32533515
28MP0004036_abnormal_muscle_relaxation1.31702159
29MP0001851_eye_inflammation1.30913908
30MP0006276_abnormal_autonomic_nervous1.29478535
31MP0002735_abnormal_chemical_nociception1.29355547
32MP0002148_abnormal_hypersensitivity_rea1.29190931
33MP0005671_abnormal_response_to1.27352720
34MP0003303_peritoneal_inflammation1.25097609
35MP0003787_abnormal_imprinting1.25063166
36MP0001545_abnormal_hematopoietic_system1.24814709
37MP0005397_hematopoietic_system_phenotyp1.24814709
38MP0006054_spinal_hemorrhage1.23852006
39MP0002398_abnormal_bone_marrow1.23230437
40MP0003828_pulmonary_edema1.22387067
41MP0008877_abnormal_DNA_methylation1.18953930
42MP0000249_abnormal_blood_vessel1.16035473
43MP0009764_decreased_sensitivity_to1.08660069
44MP0009763_increased_sensitivity_to1.03985489
45MP0005000_abnormal_immune_tolerance1.03962785
46MP0001663_abnormal_digestive_system1.03365255
47MP0002102_abnormal_ear_morphology1.02934355
48MP0004147_increased_porphyrin_level1.02912517
49MP0002132_abnormal_respiratory_system1.01188568
50MP0003566_abnormal_cell_adhesion0.99919963
51MP0001970_abnormal_pain_threshold0.98861543
52MP0009765_abnormal_xenobiotic_induced0.97968308
53MP0000689_abnormal_spleen_morphology0.95849890
54MP0003136_yellow_coat_color0.92872716
55MP0005174_abnormal_tail_pigmentation0.92457400
56MP0005551_abnormal_eye_electrophysiolog0.90385639
57MP0000383_abnormal_hair_follicle0.87924076
58MP0003656_abnormal_erythrocyte_physiolo0.87880498
59MP0004130_abnormal_muscle_cell0.87702950
60MP0005647_abnormal_sex_gland0.87087187
61MP0003879_abnormal_hair_cell0.86076607
62MP0005499_abnormal_olfactory_system0.85525108
63MP0005394_taste/olfaction_phenotype0.85525108
64MP0009642_abnormal_blood_homeostasis0.82937814
65MP0008874_decreased_physiological_sensi0.82044499
66MP0000372_irregular_coat_pigmentation0.81621384
67MP0002653_abnormal_ependyma_morphology0.79460680
68MP0001765_abnormal_ion_homeostasis0.78608831
69MP0002429_abnormal_blood_cell0.78078925
70MP0002723_abnormal_immune_serum0.74929258
71MP0004484_altered_response_of0.74490133
72MP0005187_abnormal_penis_morphology0.72367504
73MP0002722_abnormal_immune_system0.71627991
74MP0002452_abnormal_antigen_presenting0.70365645
75MP0003698_abnormal_male_reproductive0.68719880
76MP0006036_abnormal_mitochondrial_physio0.67667945
77MP0000015_abnormal_ear_pigmentation0.67573288
78MP0004947_skin_inflammation0.66425666
79MP0004142_abnormal_muscle_tone0.65943261
80MP0002128_abnormal_blood_circulation0.65908897
81MP0001800_abnormal_humoral_immune0.65550989
82MP0010094_abnormal_chromosome_stability0.63715711
83MP0004085_abnormal_heartbeat0.62989168
84MP0006138_congestive_heart_failure0.62779231
85MP0002972_abnormal_cardiac_muscle0.61976442
86MP0000858_altered_metastatic_potential0.61275412
87MP0005535_abnormal_body_temperature0.61144564
88MP0001664_abnormal_digestion0.60143542
89MP0008789_abnormal_olfactory_epithelium0.59620656
90MP0000716_abnormal_immune_system0.59494821
91MP0008057_abnormal_DNA_replication0.59019286
92MP0004381_abnormal_hair_follicle0.58055069
93MP0005645_abnormal_hypothalamus_physiol0.57421253
94MP0001845_abnormal_inflammatory_respons0.57276944
95MP0003866_abnormal_defecation0.57159566
96MP0005385_cardiovascular_system_phenoty0.56791943
97MP0001544_abnormal_cardiovascular_syste0.56791943
98MP0003183_abnormal_peptide_metabolism0.55091057
99MP0002420_abnormal_adaptive_immunity0.54755173
100MP0006035_abnormal_mitochondrial_morpho0.54726030

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)9.75530715
2Increased mean platelet volume (HP:0011877)9.70080958
3Petechiae (HP:0000967)9.07654881
4Abnormal platelet volume (HP:0011876)9.02077403
5Purpura (HP:0000979)7.86686362
6Epistaxis (HP:0000421)7.14042041
7Gingival bleeding (HP:0000225)6.44383504
8Hyperlipoproteinemia (HP:0010980)5.93831998
9Dyschromatopsia (HP:0007641)5.16201307
10Impaired platelet aggregation (HP:0003540)5.12645528
11Abnormal platelet function (HP:0011869)5.12645528
12Poikilocytosis (HP:0004447)4.24220048
13Acanthocytosis (HP:0001927)4.13756028
14Abnormal pupillary function (HP:0007686)3.81785046
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.61721898
16Spontaneous hematomas (HP:0007420)3.60417908
17Abnormality of lateral ventricle (HP:0030047)3.37763383
18Bruising susceptibility (HP:0000978)3.19413455
19Decreased central vision (HP:0007663)2.99642532
20Conjunctival telangiectasia (HP:0000524)2.97715326
21Abnormality of the common coagulation pathway (HP:0010990)2.95671848
22Upper limb muscle weakness (HP:0003484)2.74780412
23Paralysis (HP:0003470)2.73456891
24Spontaneous abortion (HP:0005268)2.69565606
25Abnormal auditory evoked potentials (HP:0006958)2.68183520
26Papillary thyroid carcinoma (HP:0002895)2.67805786
27Increased density of long bones (HP:0006392)2.65151981
28Abnormality of the vasculature of the conjunctiva (HP:0008054)2.54248729
29Joint hemorrhage (HP:0005261)2.50708415
30Stomatitis (HP:0010280)2.31972234
31Thyroid-stimulating hormone excess (HP:0002925)2.27235670
32Abnormality of the prostate (HP:0008775)2.23828333
33Xanthomatosis (HP:0000991)2.22624836
34Tinnitus (HP:0000360)2.17043239
35Increased IgM level (HP:0003496)2.16663590
36Autoimmune hemolytic anemia (HP:0001890)2.12940255
37Hepatosplenomegaly (HP:0001433)2.11534685
38Biliary tract neoplasm (HP:0100574)2.06572396
39Abnormal spermatogenesis (HP:0008669)2.06228313
40Prolonged bleeding time (HP:0003010)10.8169387
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.99969971
42Delusions (HP:0000746)1.96781706
43Nausea (HP:0002018)1.96155083
44Tongue fasciculations (HP:0001308)1.95939176
45Joint swelling (HP:0001386)1.94847414
46Abnormal ciliary motility (HP:0012262)1.92274625
47Polyphagia (HP:0002591)1.92068719
483-Methylglutaconic aciduria (HP:0003535)1.90235770
49Encephalitis (HP:0002383)1.87799825
50Generalized aminoaciduria (HP:0002909)1.87786258
51Thyroid carcinoma (HP:0002890)1.83059811
52Arterial thrombosis (HP:0004420)1.82669902
53Abnormality of iron homeostasis (HP:0011031)1.75793000
54Panhypogammaglobulinemia (HP:0003139)1.75560002
55Abnormality of transition element cation homeostasis (HP:0011030)1.75298890
56Febrile seizures (HP:0002373)1.73915418
57Abolished electroretinogram (ERG) (HP:0000550)1.73459800
58Male infertility (HP:0003251)1.71357516
59Renal cortical cysts (HP:0000803)1.70188965
60Hyperventilation (HP:0002883)1.69491338
61Muscle fibrillation (HP:0010546)1.64348320
62Abnormality of the renal cortex (HP:0011035)1.59644344
63Acute hepatic failure (HP:0006554)1.55151447
64Widely spaced teeth (HP:0000687)1.54787285
65Amaurosis fugax (HP:0100576)1.52212567
66Transitional cell carcinoma of the bladder (HP:0006740)1.51973653
67Absent speech (HP:0001344)1.50698499
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.50456252
69Absent/shortened dynein arms (HP:0200106)1.50456252
70Tented upper lip vermilion (HP:0010804)1.50386475
71Hypophosphatemic rickets (HP:0004912)1.48820920
72Infertility (HP:0000789)1.48756912
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.46211229
74Abnormality of alanine metabolism (HP:0010916)1.46211229
75Hyperalaninemia (HP:0003348)1.46211229
76Central scotoma (HP:0000603)1.45817295
77Ectopic kidney (HP:0000086)1.45559708
78Myelodysplasia (HP:0002863)1.43223938
79Abnormal respiratory motile cilium morphology (HP:0005938)1.41597429
80Abnormal respiratory epithelium morphology (HP:0012253)1.41597429
81Delayed puberty (HP:0000823)1.41589134
82Leiomyosarcoma (HP:0100243)1.41399192
83Uterine leiomyosarcoma (HP:0002891)1.41399192
84Bladder carcinoma (HP:0002862)1.37361238
85Bladder neoplasm (HP:0009725)1.37361238
86Male pseudohermaphroditism (HP:0000037)1.37194042
87Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.34946206
88Eosinophilia (HP:0001880)1.34039957
89Abnormality of male internal genitalia (HP:0000022)1.33289839
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.32774221
91Pancreatic cysts (HP:0001737)1.32654475
92Aplasia/Hypoplasia of the uvula (HP:0010293)1.32121565
93Azoospermia (HP:0000027)1.31970069
94Vertigo (HP:0002321)1.31588803
95Abnormality of B cell number (HP:0010975)1.31515347
96Episodic fever (HP:0001954)1.30694441
97Amyotrophic lateral sclerosis (HP:0007354)1.30488590
98Gonadal dysgenesis (HP:0000133)1.27072529
99Chest pain (HP:0100749)1.26877658
100Hypoproteinemia (HP:0003075)1.26696165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.64170856
2EIF2AK13.46911405
3BMX3.42861319
4RIPK43.19413284
5TEC2.88104896
6MYLK2.87532737
7BTK2.59574014
8NUAK12.47540785
9TAOK32.24998810
10PTK2B2.15401549
11EIF2AK32.10400374
12ACVR1B1.92155962
13GRK51.89654342
14TRIM281.86997841
15PLK21.82755007
16CSF1R1.80917853
17PIK3CG1.80108692
18SYK1.80073910
19TNK21.77116273
20BMPR21.69479294
21ADRBK21.67405316
22MAPK131.64915433
23MAP4K21.64905779
24STK391.63054173
25FRK1.61762433
26STK31.58729504
27BMPR1B1.56909390
28IRAK11.54274835
29FER1.41089907
30ILK1.28270596
31ZAK1.27258757
32GRK61.25043196
33PNCK1.16069826
34FGR1.12328147
35IRAK21.12094772
36MAPKAPK31.01442707
37OXSR10.98372765
38WNK30.97329986
39LYN0.96559093
40HCK0.94641813
41PKN10.93511730
42PAK10.91135491
43EPHA30.90241087
44PAK30.89637928
45PIM20.87977204
46TNIK0.85948325
47MAP3K50.85885862
48FES0.83520185
49ADRBK10.83159680
50MINK10.81612818
51DYRK20.81608012
52INSRR0.78217080
53MATK0.75229014
54BRSK20.74748314
55PLK30.70030113
56ITK0.69541048
57IKBKB0.69441333
58DAPK30.69128696
59SGK20.69103095
60VRK10.66328701
61CDC70.64783937
62SIK30.62323564
63ZAP700.59949488
64LMTK20.59781881
65MAP3K120.58889425
66TLK10.58333821
67CAMK1G0.56245592
68MARK30.55959248
69PRKCE0.54397960
70YES10.54282802
71PRKD10.54207110
72EPHB20.54055291
73GRK10.53369501
74ERBB20.50705128
75MAP2K10.49712300
76TXK0.48004738
77DAPK20.47671780
78PRKG10.45914849
79BLK0.44755200
80BCR0.44193001
81AKT30.44180252
82ERBB30.43602995
83PRKACG0.40507909
84IGF1R0.40077465
85DYRK1A0.36698481
86ROCK10.36565660
87PDK10.35605941
88PRKCB0.33429832
89DAPK10.30726791
90STK40.30639260
91PRKCQ0.30634704
92PRKCA0.30547156
93LCK0.27980512
94CAMK2A0.27711955
95ABL10.27134715
96SGK30.27078503
97CSNK1D0.26788551
98MKNK10.25323435
99PRKCG0.23126774
100GSK3A0.21261529

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.64994455
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.68170025
3SNARE interactions in vesicular transport_Homo sapiens_hsa041303.21116718
4Nitrogen metabolism_Homo sapiens_hsa009102.78571696
5Arachidonic acid metabolism_Homo sapiens_hsa005902.49217439
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.39896946
7Mismatch repair_Homo sapiens_hsa034302.30603996
8Hematopoietic cell lineage_Homo sapiens_hsa046402.21555793
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08458145
10ECM-receptor interaction_Homo sapiens_hsa045121.96218507
11Serotonergic synapse_Homo sapiens_hsa047261.95319317
12Gap junction_Homo sapiens_hsa045401.79752482
13Linoleic acid metabolism_Homo sapiens_hsa005911.75528748
14Fatty acid elongation_Homo sapiens_hsa000621.72218744
15Systemic lupus erythematosus_Homo sapiens_hsa053221.60507942
16Alcoholism_Homo sapiens_hsa050341.58547071
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.55384639
18Phototransduction_Homo sapiens_hsa047441.52507030
19Glycerolipid metabolism_Homo sapiens_hsa005611.49876288
20Olfactory transduction_Homo sapiens_hsa047401.45719121
21Chemokine signaling pathway_Homo sapiens_hsa040621.40644575
22Collecting duct acid secretion_Homo sapiens_hsa049661.39335461
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32879899
24Pancreatic secretion_Homo sapiens_hsa049721.27563794
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25087173
26Glutathione metabolism_Homo sapiens_hsa004801.22199999
27Primary immunodeficiency_Homo sapiens_hsa053401.22102201
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.20518311
29Circadian entrainment_Homo sapiens_hsa047131.18966232
30Long-term depression_Homo sapiens_hsa047301.16695323
31Steroid biosynthesis_Homo sapiens_hsa001001.13804822
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13649108
33Homologous recombination_Homo sapiens_hsa034401.08182253
34Sulfur metabolism_Homo sapiens_hsa009201.05474987
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04835482
36Morphine addiction_Homo sapiens_hsa050321.03265016
37Non-homologous end-joining_Homo sapiens_hsa034501.03195345
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97240182
39Fanconi anemia pathway_Homo sapiens_hsa034600.94431005
40Chemical carcinogenesis_Homo sapiens_hsa052040.94178914
41Endocytosis_Homo sapiens_hsa041440.92211564
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89874730
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85113756
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83402001
45Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82493462
46GABAergic synapse_Homo sapiens_hsa047270.82215924
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80922912
48Fat digestion and absorption_Homo sapiens_hsa049750.76699284
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.72951510
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.71257799
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70181307
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68366349
53Calcium signaling pathway_Homo sapiens_hsa040200.65230215
54Ether lipid metabolism_Homo sapiens_hsa005650.62412317
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61480967
56Asthma_Homo sapiens_hsa053100.59962776
57Sphingolipid metabolism_Homo sapiens_hsa006000.59442515
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.59394949
59Purine metabolism_Homo sapiens_hsa002300.59149940
60Butanoate metabolism_Homo sapiens_hsa006500.56700307
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55919089
62Fatty acid biosynthesis_Homo sapiens_hsa000610.55914127
63Starch and sucrose metabolism_Homo sapiens_hsa005000.55786485
64Cholinergic synapse_Homo sapiens_hsa047250.53869268
65Phagosome_Homo sapiens_hsa041450.51202358
66Base excision repair_Homo sapiens_hsa034100.50024240
67Glutamatergic synapse_Homo sapiens_hsa047240.49379586
68Rap1 signaling pathway_Homo sapiens_hsa040150.49311004
69Caffeine metabolism_Homo sapiens_hsa002320.48438734
70B cell receptor signaling pathway_Homo sapiens_hsa046620.48195874
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.48183758
72beta-Alanine metabolism_Homo sapiens_hsa004100.47958759
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47948263
74Choline metabolism in cancer_Homo sapiens_hsa052310.47774719
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47456988
76Pentose phosphate pathway_Homo sapiens_hsa000300.47366592
77Renin secretion_Homo sapiens_hsa049240.46466477
78Viral carcinogenesis_Homo sapiens_hsa052030.45300223
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44048672
80Retinol metabolism_Homo sapiens_hsa008300.41622655
81Salivary secretion_Homo sapiens_hsa049700.41091190
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40209390
83Shigellosis_Homo sapiens_hsa051310.38423504
84Ovarian steroidogenesis_Homo sapiens_hsa049130.37791145
85Regulation of autophagy_Homo sapiens_hsa041400.36447771
86Ras signaling pathway_Homo sapiens_hsa040140.36229419
87Melanoma_Homo sapiens_hsa052180.35305733
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35038102
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34639298
90Gastric acid secretion_Homo sapiens_hsa049710.34162171
91Peroxisome_Homo sapiens_hsa041460.33908107
92Dopaminergic synapse_Homo sapiens_hsa047280.32527379
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32016632
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.31962882
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.30749556
96PPAR signaling pathway_Homo sapiens_hsa033200.28464471
97Renin-angiotensin system_Homo sapiens_hsa046140.28274271
98Pyrimidine metabolism_Homo sapiens_hsa002400.27873974
99Nucleotide excision repair_Homo sapiens_hsa034200.25552413
100Staphylococcus aureus infection_Homo sapiens_hsa051500.25271351

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