ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	replication fork processing (GO:0031297)	5.39837755
2	DNA double-strand break processing (GO:0000729)	4.88807740
3	protein K6-linked ubiquitination (GO:0085020)	4.86971321
4	microtubule depolymerization (GO:0007019)	4.80917490
5	protein neddylation (GO:0045116)	4.72016326
6	presynaptic membrane assembly (GO:0097105)	4.71389462
7	limb bud formation (GO:0060174)	4.59455780
8	pyrimidine nucleobase catabolic process (GO:0006208)	4.44854550
9	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	4.37716129
10	presynaptic membrane organization (GO:0097090)	3.87034919
11	regulation of translation, ncRNA-mediated (GO:0045974)	3.81409860
12	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.81409860
13	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.81409860
14	histone H2A acetylation (GO:0043968)	3.74048079
15	centriole replication (GO:0007099)	3.61384797
16	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.56949636
17	neural tube formation (GO:0001841)	3.55927913
18	chromatin remodeling at centromere (GO:0031055)	3.55581220
19	intraciliary transport (GO:0042073)	3.48040195
20	histone exchange (GO:0043486)	3.42751769
21	microtubule polymerization or depolymerization (GO:0031109)	3.42474604
22	DNA strand renaturation (GO:0000733)	3.40986474
23	retinal cone cell development (GO:0046549)	3.36567162
24	postreplication repair (GO:0006301)	3.34093764
25	nucleobase catabolic process (GO:0046113)	3.31431922
26	DNA replication-dependent nucleosome assembly (GO:0006335)	3.27389793
27	DNA replication-dependent nucleosome organization (GO:0034723)	3.27389793
28	translesion synthesis (GO:0019985)	3.25037633
29	acrosome assembly (GO:0001675)	3.23682289
30	regulation of cilium movement (GO:0003352)	3.22762546
31	CENP-A containing nucleosome assembly (GO:0034080)	3.22646735
32	nonmotile primary cilium assembly (GO:0035058)	3.21230549
33	recombinational repair (GO:0000725)	3.20902563
34	double-strand break repair via homologous recombination (GO:0000724)	3.19378828
35	negative regulation of DNA recombination (GO:0045910)	3.14590173
36	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.12803023
37	kinetochore organization (GO:0051383)	3.11981517
38	postsynaptic membrane organization (GO:0001941)	3.06350320
39	kinetochore assembly (GO:0051382)	3.05558253
40	cerebral cortex radially oriented cell migration (GO:0021799)	3.03541210
41	cell proliferation in forebrain (GO:0021846)	3.02259598
42	DNA integration (GO:0015074)	3.02037210
43	fibroblast migration (GO:0010761)	2.99308012
44	microtubule anchoring (GO:0034453)	2.95349619
45	mitotic sister chromatid cohesion (GO:0007064)	2.95052160
46	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.94120946
47	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.94120946
48	long-chain fatty acid biosynthetic process (GO:0042759)	2.90217126
49	cilium organization (GO:0044782)	2.89699832
50	negative regulation of neurotransmitter transport (GO:0051589)	2.89168065
51	regulation of timing of cell differentiation (GO:0048505)	2.87765700
52	cilium assembly (GO:0042384)	2.85326125
53	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.83673679
54	mitotic sister chromatid segregation (GO:0000070)	2.77515184
55	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.75612335
56	male meiosis (GO:0007140)	2.74450872
57	cilium morphogenesis (GO:0060271)	2.73533813
58	protein polyglutamylation (GO:0018095)	2.72954752
59	DNA replication-independent nucleosome assembly (GO:0006336)	2.72750771
60	DNA replication-independent nucleosome organization (GO:0034724)	2.72750771
61	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.72138351
62	regulation of development, heterochronic (GO:0040034)	2.69085219
63	regulation of integrin-mediated signaling pathway (GO:2001044)	2.68911281
64	artery development (GO:0060840)	2.67001299
65	epithelial cilium movement (GO:0003351)	2.65736311
66	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.65481347
67	sister chromatid segregation (GO:0000819)	2.64629956
68	olfactory bulb development (GO:0021772)	2.64594082
69	smoothened signaling pathway (GO:0007224)	2.59067953
70	neuronal action potential propagation (GO:0019227)	2.59028777
71	meiotic chromosome segregation (GO:0045132)	2.58779919
72	ether lipid metabolic process (GO:0046485)	2.58117273
73	DNA catabolic process, exonucleolytic (GO:0000738)	2.57915935
74	adenosine metabolic process (GO:0046085)	2.56778733
75	N-terminal protein amino acid acetylation (GO:0006474)	2.56406874
76	inner ear receptor stereocilium organization (GO:0060122)	2.53887635
77	DNA ligation (GO:0006266)	2.53354698
78	microtubule organizing center organization (GO:0031023)	2.52488807
79	sympathetic nervous system development (GO:0048485)	2.52233069
80	centrosome organization (GO:0051297)	2.52201924
81	spermatid nucleus differentiation (GO:0007289)	2.50699490
82	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.50153406
83	synapsis (GO:0007129)	2.49619030
84	regulation of DNA endoreduplication (GO:0032875)	2.49449579
85	sperm motility (GO:0030317)	2.46364433
86	regulation of meiosis I (GO:0060631)	2.44137593
87	double-strand break repair (GO:0006302)	2.43706184
88	reciprocal DNA recombination (GO:0035825)	2.43649366
89	reciprocal meiotic recombination (GO:0007131)	2.43649366
90	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.42709801
91	negative regulation of astrocyte differentiation (GO:0048712)	2.42175583
92	photoreceptor cell development (GO:0042461)	2.41835742
93	negative regulation of heart rate (GO:0010459)	2.40918447
94	mismatch repair (GO:0006298)	2.39093463
95	retinal ganglion cell axon guidance (GO:0031290)	2.37347306
96	GMP metabolic process (GO:0046037)	2.36988862
97	positive regulation of amino acid transport (GO:0051957)	2.36768057
98	tongue development (GO:0043586)	2.35949460
99	protein heterotetramerization (GO:0051290)	2.34794077
100	thrombin receptor signaling pathway (GO:0070493)	2.34055543

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.45217647
2	E2F7_22180533_ChIP-Seq_HELA_Human	3.15009921
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.09859706
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.09253506
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.98815847
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.95247000
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.87887193
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.73431363
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.62529632
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.58508198
11	EWS_26573619_Chip-Seq_HEK293_Human	2.49309209
12	FUS_26573619_Chip-Seq_HEK293_Human	2.45778963
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.45394481
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.42249061
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.38050476
16	VDR_22108803_ChIP-Seq_LS180_Human	2.33265252
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.30789811
18	P300_19829295_ChIP-Seq_ESCs_Human	2.28035326
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.18590154
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.10374027
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.10081434
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.03277980
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94997668
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.89203567
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.84738335
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84293266
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.78858131
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.76260769
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72091275
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.67284057
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66728643
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66368147
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.66348681
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.65409213
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.58901535
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58901535
37	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54818257
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53044185
39	AR_25329375_ChIP-Seq_VCAP_Human	1.50977329
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.49904135
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.48577426
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.46849939
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45121524
44	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.41989513
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.41453853
46	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.40064416
47	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.38109799
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37410760
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37294894
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36734301
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.36734301
52	STAT3_23295773_ChIP-Seq_U87_Human	1.36234672
53	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.34520319
54	TCF4_23295773_ChIP-Seq_U87_Human	1.30573145
55	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.29574832
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.28104599
57	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.26065125
58	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.25203439
59	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24592303
60	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.24234961
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24018087
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.23806076
63	HTT_18923047_ChIP-ChIP_STHdh_Human	1.20355724
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20064848
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19019923
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18752622
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18607357
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17767100
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16003688
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.15360477
71	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.14227190
72	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13842590
73	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13704504
74	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.13465055
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11814664
76	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10398968
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10242248
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.09730618
79	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09698504
80	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09430774
81	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.09277716
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.09170947
83	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09098655
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08392639
85	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07737054
86	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07737054
87	JUN_21703547_ChIP-Seq_K562_Human	1.06130903
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06023646
89	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05290333
90	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.04379247
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04265248
92	TBL1_22424771_ChIP-Seq_293T_Human	1.02189154
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01914390
94	TP53_16413492_ChIP-PET_HCT116_Human	1.00684528
95	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.99834196
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98801171
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.97821549
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97803579
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97665297
100	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97629633

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.25833703
2	MP0008877_abnormal_DNA_methylation	3.17469969
3	MP0000566_synostosis	3.01826658
4	MP0002102_abnormal_ear_morphology	2.97619587
5	MP0010094_abnormal_chromosome_stability	2.86502928
6	MP0008789_abnormal_olfactory_epithelium	2.67194649
7	MP0005394_taste/olfaction_phenotype	2.59381869
8	MP0005499_abnormal_olfactory_system	2.59381869
9	MP0002736_abnormal_nociception_after	2.43092586
10	MP0009697_abnormal_copulation	2.32727377
11	MP0002938_white_spotting	2.32489864
12	MP0003880_abnormal_central_pattern	2.30104829
13	MP0008058_abnormal_DNA_repair	2.19865471
14	MP0002234_abnormal_pharynx_morphology	2.11636618
15	MP0003121_genomic_imprinting	2.02219710
16	MP0006276_abnormal_autonomic_nervous	1.95734016
17	MP0000778_abnormal_nervous_system	1.90809388
18	MP0001529_abnormal_vocalization	1.89731449
19	MP0005248_abnormal_Harderian_gland	1.89658747
20	MP0005646_abnormal_pituitary_gland	1.86295487
21	MP0001293_anophthalmia	1.82129273
22	MP0001984_abnormal_olfaction	1.75647701
23	MP0005551_abnormal_eye_electrophysiolog	1.71414142
24	MP0002233_abnormal_nose_morphology	1.70720119
25	MP0000372_irregular_coat_pigmentation	1.67378837
26	MP0001486_abnormal_startle_reflex	1.63541497
27	MP0005253_abnormal_eye_physiology	1.61971278
28	MP0003938_abnormal_ear_development	1.61162785
29	MP0001968_abnormal_touch/_nociception	1.55995401
30	MP0003718_maternal_effect	1.54613194
31	MP0003937_abnormal_limbs/digits/tail_de	1.52523034
32	MP0005464_abnormal_platelet_physiology	1.47208508
33	MP0003122_maternal_imprinting	1.46635454
34	MP0002751_abnormal_autonomic_nervous	1.45931948
35	MP0000631_abnormal_neuroendocrine_gland	1.44912955
36	MP0003111_abnormal_nucleus_morphology	1.44632724
37	MP0006072_abnormal_retinal_apoptosis	1.42824919
38	MP0003787_abnormal_imprinting	1.41663644
39	MP0008004_abnormal_stomach_pH	1.37522028
40	MP0008872_abnormal_physiological_respon	1.36708915
41	MP0005084_abnormal_gallbladder_morpholo	1.32053483
42	MP0005410_abnormal_fertilization	1.29393523
43	MP0000569_abnormal_digit_pigmentation	1.28364477
44	MP0000049_abnormal_middle_ear	1.22804835
45	MP0003755_abnormal_palate_morphology	1.22588206
46	MP0005187_abnormal_penis_morphology	1.21397781
47	MP0008932_abnormal_embryonic_tissue	1.21304094
48	MP0008057_abnormal_DNA_replication	1.20950778
49	MP0000647_abnormal_sebaceous_gland	1.20773974
50	MP0003698_abnormal_male_reproductive	1.20035610
51	MP0004215_abnormal_myocardial_fiber	1.18502173
52	MP0000383_abnormal_hair_follicle	1.17863259
53	MP0000579_abnormal_nail_morphology	1.17017631
54	MP0001485_abnormal_pinna_reflex	1.15869924
55	MP0001929_abnormal_gametogenesis	1.14805285
56	MP0002282_abnormal_trachea_morphology	1.12378049
57	MP0003119_abnormal_digestive_system	1.11396128
58	MP0005391_vision/eye_phenotype	1.10279568
59	MP0001188_hyperpigmentation	1.06543943
60	MP0002557_abnormal_social/conspecific_i	1.05949139
61	MP0001286_abnormal_eye_development	1.05553553
62	MP0002735_abnormal_chemical_nociception	1.04784839
63	MP0003567_abnormal_fetal_cardiomyocyte	1.01638145
64	MP0003136_yellow_coat_color	1.01485285
65	MP0005171_absent_coat_pigmentation	0.98927880
66	MP0002697_abnormal_eye_size	0.98509161
67	MP0009053_abnormal_anal_canal	0.97508340
68	MP0000026_abnormal_inner_ear	0.97415020
69	MP0002653_abnormal_ependyma_morphology	0.96764349
70	MP0010030_abnormal_orbit_morphology	0.95489414
71	MP0003861_abnormal_nervous_system	0.93329209
72	MP0005395_other_phenotype	0.93296321
73	MP0002210_abnormal_sex_determination	0.93153758
74	MP0009046_muscle_twitch	0.92886294
75	MP0005195_abnormal_posterior_eye	0.90702460
76	MP0001177_atelectasis	0.88144623
77	MP0004142_abnormal_muscle_tone	0.87648011
78	MP0002638_abnormal_pupillary_reflex	0.86433089
79	MP0002752_abnormal_somatic_nervous	0.85366017
80	MP0000653_abnormal_sex_gland	0.85254860
81	MP0000427_abnormal_hair_cycle	0.85219758
82	MP0009745_abnormal_behavioral_response	0.84469874
83	MP0002272_abnormal_nervous_system	0.83033782
84	MP0000230_abnormal_systemic_arterial	0.82198924
85	MP0009703_decreased_birth_body	0.79960419
86	MP0005174_abnormal_tail_pigmentation	0.79468268
87	MP0003935_abnormal_craniofacial_develop	0.79451478
88	MP0005647_abnormal_sex_gland	0.78594358
89	MP0002152_abnormal_brain_morphology	0.77415868
90	MP0003077_abnormal_cell_cycle	0.76569549
91	MP0001145_abnormal_male_reproductive	0.75694003
92	MP0003123_paternal_imprinting	0.72707211
93	MP0001764_abnormal_homeostasis	0.72497662
94	MP0002111_abnormal_tail_morphology	0.72472681
95	MP0004133_heterotaxia	0.71553915
96	MP0001970_abnormal_pain_threshold	0.71394092
97	MP0002067_abnormal_sensory_capabilities	0.71291714
98	MP0004885_abnormal_endolymph	0.71186828
99	MP0008775_abnormal_heart_ventricle	0.70586670
100	MP0002572_abnormal_emotion/affect_behav	0.70059532

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	4.39199646
2	Amyotrophic lateral sclerosis (HP:0007354)	3.87727211
3	True hermaphroditism (HP:0010459)	3.43090870
4	Abnormality of lateral ventricle (HP:0030047)	3.21748452
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.21447388
6	Abnormality of the lower motor neuron (HP:0002366)	3.17383336
7	Pancreatic cysts (HP:0001737)	3.16958470
8	Chromsome breakage (HP:0040012)	3.10579756
9	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.07935426
10	Intestinal atresia (HP:0011100)	3.04159637
11	Volvulus (HP:0002580)	3.03400964
12	Meckel diverticulum (HP:0002245)	2.99663101
13	Pancreatic fibrosis (HP:0100732)	2.98595936
14	Abnormality of the ileum (HP:0001549)	2.97016193
15	Molar tooth sign on MRI (HP:0002419)	2.92284265
16	Abnormality of midbrain morphology (HP:0002418)	2.92284265
17	Ectopic kidney (HP:0000086)	2.79006524
18	Abnormality of chromosome stability (HP:0003220)	2.77507495
19	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.63532776
20	Dyschromatopsia (HP:0007641)	2.54941917
21	Renal hypoplasia (HP:0000089)	2.54861106
22	Hypoplastic pelvis (HP:0008839)	2.51160412
23	Increased mean platelet volume (HP:0011877)	2.48950206
24	Chronic hepatic failure (HP:0100626)	2.42613240
25	Tented upper lip vermilion (HP:0010804)	2.39174314
26	Abnormal lung lobation (HP:0002101)	2.38070500
27	Nephronophthisis (HP:0000090)	2.34563090
28	Sloping forehead (HP:0000340)	2.33171236
29	Oligodactyly (HP:0012165)	2.31321852
30	Carpal bone hypoplasia (HP:0001498)	2.30743389
31	Delusions (HP:0000746)	2.30461244
32	Dyskinesia (HP:0100660)	2.29386449
33	Prolonged bleeding time (HP:0003010)	2.29166694
34	Menorrhagia (HP:0000132)	2.26153961
35	Abnormality of the preputium (HP:0100587)	2.25726424
36	Hyperglycinemia (HP:0002154)	2.25612069
37	Medial flaring of the eyebrow (HP:0010747)	2.24848251
38	Cystic liver disease (HP:0006706)	2.24661894
39	Short 4th metacarpal (HP:0010044)	2.21422923
40	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.21422923
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21270023
42	Duodenal stenosis (HP:0100867)	2.20394755
43	Small intestinal stenosis (HP:0012848)	2.20394755
44	Hypoplastic female external genitalia (HP:0012815)	2.19957518
45	Rhabdomyosarcoma (HP:0002859)	2.19403341
46	Tetraparesis (HP:0002273)	2.18755162
47	Astrocytoma (HP:0009592)	2.18172221
48	Abnormality of the astrocytes (HP:0100707)	2.18172221
49	Abnormality of the renal medulla (HP:0100957)	2.17123615
50	Drooling (HP:0002307)	2.15809654
51	Anencephaly (HP:0002323)	2.15794265
52	Triphalangeal thumb (HP:0001199)	2.14727075
53	Hypoplastic labia majora (HP:0000059)	2.14187415
54	Febrile seizures (HP:0002373)	2.13320514
55	Facial hemangioma (HP:0000329)	2.12268862
56	Abnormal platelet volume (HP:0011876)	2.12248224
57	Tubulointerstitial nephritis (HP:0001970)	2.11240204
58	Abnormality of the duodenum (HP:0002246)	2.09826055
59	Male pseudohermaphroditism (HP:0000037)	2.09057032
60	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.07089397
61	Postaxial foot polydactyly (HP:0001830)	2.06947327
62	Optic nerve hypoplasia (HP:0000609)	2.05519613
63	Upper limb muscle weakness (HP:0003484)	2.03356645
64	Decreased central vision (HP:0007663)	2.01893267
65	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01033960
66	Bifid scrotum (HP:0000048)	2.00739873
67	Genital tract atresia (HP:0001827)	2.00707638
68	Colon cancer (HP:0003003)	2.00329588
69	Oligodactyly (hands) (HP:0001180)	1.98813697
70	Glioma (HP:0009733)	1.98691454
71	Vaginal atresia (HP:0000148)	1.97911066
72	Labial hypoplasia (HP:0000066)	1.97630330
73	Abnormality of the labia majora (HP:0012881)	1.96516145
74	Ependymoma (HP:0002888)	1.95879027
75	Gastrointestinal atresia (HP:0002589)	1.95408014
76	Postaxial hand polydactyly (HP:0001162)	1.94854670
77	Aqueductal stenosis (HP:0002410)	1.93667817
78	Abnormality of the renal cortex (HP:0011035)	1.92955177
79	Hypoplastic nipples (HP:0002557)	1.92882274
80	Excessive salivation (HP:0003781)	1.92852965
81	Hyperventilation (HP:0002883)	1.91972586
82	Congenital primary aphakia (HP:0007707)	1.91928961
83	Abolished electroretinogram (ERG) (HP:0000550)	1.91307763
84	Gait imbalance (HP:0002141)	1.90865525
85	Sclerocornea (HP:0000647)	1.89498759
86	Abnormal spermatogenesis (HP:0008669)	1.89378536
87	Preaxial hand polydactyly (HP:0001177)	1.88836747
88	Specific learning disability (HP:0001328)	1.87350913
89	Lissencephaly (HP:0001339)	1.86978645
90	Astigmatism (HP:0000483)	1.86816349
91	Nephrogenic diabetes insipidus (HP:0009806)	1.85910044
92	Growth hormone deficiency (HP:0000824)	1.85422338
93	Hypoplastic iliac wings (HP:0002866)	1.84569768
94	Small hand (HP:0200055)	1.84540036
95	Hyperlipoproteinemia (HP:0010980)	1.84471441
96	Biliary tract neoplasm (HP:0100574)	1.83505717
97	Papillary thyroid carcinoma (HP:0002895)	1.78827790
98	Abnormality of the carotid arteries (HP:0005344)	1.78622990
99	Cortical dysplasia (HP:0002539)	1.77018768
100	Clubbing of toes (HP:0100760)	1.76781514

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	3.45612429
2	TRIM28	3.26333714
3	BRSK2	2.75178140
4	NUAK1	2.71930645
5	MAPK13	2.42155421
6	BMPR1B	2.36341869
7	FRK	2.27290046
8	WEE1	2.17691088
9	PRKD3	2.06647112
10	MST4	2.04824019
11	CDC7	2.01589102
12	BCR	2.01007024
13	ZAK	1.96695552
14	EIF2AK1	1.96295842
15	MAP4K2	1.87802267
16	PLK2	1.86558298
17	PLK4	1.78916203
18	MKNK2	1.75310928
19	MAP3K4	1.70129286
20	PINK1	1.69822592
21	PNCK	1.68640241
22	PLK3	1.64125030
23	EIF2AK3	1.60621562
24	ERBB3	1.59707704
25	TNIK	1.54895802
26	EPHA4	1.53567208
27	ACVR1B	1.51635640
28	MARK1	1.51431266
29	EPHB2	1.37375938
30	CCNB1	1.36556256
31	NEK1	1.33442102
32	ADRBK2	1.33244226
33	INSRR	1.27245733
34	CASK	1.26790891
35	DYRK2	1.26387093
36	MINK1	1.25971462
37	SRPK1	1.23098528
38	PKN1	1.21840965
39	MAP2K7	1.21007186
40	PAK3	1.17517075
41	MKNK1	1.16107018
42	BRD4	1.07274201
43	TAF1	0.98869350
44	STK39	0.97955403
45	TGFBR1	0.97619582
46	MARK3	0.96146381
47	VRK1	0.95695766
48	TTK	0.92426324
49	AKT3	0.91903330
50	BUB1	0.91820725
51	PTK2B	0.91434397
52	NTRK2	0.88491874
53	BRSK1	0.88310057
54	TNK2	0.86192701
55	CSNK1G1	0.84865309
56	PLK1	0.83119489
57	GRK1	0.82507681
58	DYRK3	0.79729150
59	PRKCE	0.76127643
60	STK3	0.71239234
61	TAOK1	0.70895118
62	GRK5	0.69018231
63	ATM	0.66485653
64	ATR	0.66386840
65	SGK2	0.65365353
66	CSNK1G3	0.65357602
67	CSNK1G2	0.63301204
68	BCKDK	0.62769987
69	CAMK1G	0.60106998
70	YES1	0.60037818
71	TLK1	0.59574262
72	PRKCG	0.58939659
73	SIK3	0.58244168
74	CDK3	0.57810434
75	OXSR1	0.57702186
76	WNK4	0.56506396
77	VRK2	0.55467586
78	PIK3CG	0.55104067
79	CHEK2	0.54657784
80	EPHA3	0.51104968
81	DYRK1A	0.50499576
82	STK16	0.50214863
83	FGFR2	0.49135127
84	BMX	0.48985674
85	ROCK1	0.47480228
86	TSSK6	0.46724712
87	CSNK1A1L	0.46450051
88	MAP3K5	0.45924451
89	TEC	0.45468555
90	FGR	0.41453030
91	PRKG1	0.38101730
92	MAP2K4	0.36960895
93	FER	0.35258434
94	ADRBK1	0.34083521
95	MYLK	0.31862069
96	IRAK1	0.31623571
97	PRKCH	0.29800385
98	MAP3K10	0.29756369
99	EIF2AK2	0.29151194
100	STK38L	0.29028748

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	3.43928112
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.41547017
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.31345604
4	Homologous recombination_Homo sapiens_hsa03440	3.15357271
5	Mismatch repair_Homo sapiens_hsa03430	3.11074690
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.78911359
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.19966434
8	Propanoate metabolism_Homo sapiens_hsa00640	2.14723787
9	Phototransduction_Homo sapiens_hsa04744	2.09538953
10	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.93671761
11	Protein export_Homo sapiens_hsa03060	1.92533466
12	DNA replication_Homo sapiens_hsa03030	1.92050034
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.91038022
14	Butanoate metabolism_Homo sapiens_hsa00650	1.85449893
15	Basal transcription factors_Homo sapiens_hsa03022	1.66492120
16	Base excision repair_Homo sapiens_hsa03410	1.55767528
17	Nicotine addiction_Homo sapiens_hsa05033	1.49611829
18	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.45132020
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.44492658
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40711528
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40159372
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38606236
23	Cell cycle_Homo sapiens_hsa04110	1.30569323
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.28408394
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.24191464
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.23071558
27	Olfactory transduction_Homo sapiens_hsa04740	1.22019899
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21084036
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18624128
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.17604014
31	Caffeine metabolism_Homo sapiens_hsa00232	1.17421084
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13313814
33	Basal cell carcinoma_Homo sapiens_hsa05217	1.09281917
34	Serotonergic synapse_Homo sapiens_hsa04726	1.06628240
35	Gap junction_Homo sapiens_hsa04540	1.03608660
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02145966
37	Lysine degradation_Homo sapiens_hsa00310	0.98071954
38	One carbon pool by folate_Homo sapiens_hsa00670	0.97347597
39	RNA polymerase_Homo sapiens_hsa03020	0.97026617
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96238461
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95130998
42	RNA transport_Homo sapiens_hsa03013	0.93802592
43	Oocyte meiosis_Homo sapiens_hsa04114	0.93053283
44	GABAergic synapse_Homo sapiens_hsa04727	0.92565231
45	Alcoholism_Homo sapiens_hsa05034	0.90968481
46	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.90438183
47	Platelet activation_Homo sapiens_hsa04611	0.89147485
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89081065
49	RNA degradation_Homo sapiens_hsa03018	0.88706212
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85787639
51	Morphine addiction_Homo sapiens_hsa05032	0.84788413
52	Purine metabolism_Homo sapiens_hsa00230	0.83460593
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83369990
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.83368319
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.83332618
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80173125
57	p53 signaling pathway_Homo sapiens_hsa04115	0.79175440
58	Glutathione metabolism_Homo sapiens_hsa00480	0.79096682
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78908064
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73694746
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73661505
62	Circadian entrainment_Homo sapiens_hsa04713	0.73450799
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.73138785
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72193265
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.69683223
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69611909
67	Cocaine addiction_Homo sapiens_hsa05030	0.69323367
68	Wnt signaling pathway_Homo sapiens_hsa04310	0.69252845
69	Taste transduction_Homo sapiens_hsa04742	0.67457371
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.65208279
71	Spliceosome_Homo sapiens_hsa03040	0.64071772
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.61949496
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.61593312
74	Hippo signaling pathway_Homo sapiens_hsa04390	0.60066752
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59838005
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.58407482
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58004283
78	Fatty acid elongation_Homo sapiens_hsa00062	0.56287601
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55750934
80	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.55044156
81	Peroxisome_Homo sapiens_hsa04146	0.54677791
82	Long-term depression_Homo sapiens_hsa04730	0.53570357
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53422140
84	Fatty acid degradation_Homo sapiens_hsa00071	0.53035509
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.52942460
86	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52676890
87	Retinol metabolism_Homo sapiens_hsa00830	0.52658803
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52590814
89	Axon guidance_Homo sapiens_hsa04360	0.50822346
90	Amphetamine addiction_Homo sapiens_hsa05031	0.50615453
91	ECM-receptor interaction_Homo sapiens_hsa04512	0.49565360
92	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.48343564
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.48243516
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.45681308
95	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42019131
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.41964496
97	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41705994
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.41477548
99	Selenocompound metabolism_Homo sapiens_hsa00450	0.40855921
100	Metabolic pathways_Homo sapiens_hsa01100	0.39677131

GLYATL1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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