ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of temperature stimulus involved in sensory perception (GO:0050961)	8.91301156
2	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	8.91301156
3	detection of temperature stimulus (GO:0016048)	7.58893592
4	auditory receptor cell differentiation (GO:0042491)	7.34653907
5	spermatid nucleus differentiation (GO:0007289)	6.14563178
6	positive regulation of steroid hormone secretion (GO:2000833)	4.84527633
7	cellular ketone body metabolic process (GO:0046950)	4.54562605
8	acrosome assembly (GO:0001675)	4.49723196
9	endocrine hormone secretion (GO:0060986)	4.48395982
10	hair cell differentiation (GO:0035315)	4.41689151
11	epoxygenase P450 pathway (GO:0019373)	4.36492802
12	oxidative demethylation (GO:0070989)	4.17410255
13	primary amino compound metabolic process (GO:1901160)	4.17337221
14	inner ear receptor cell differentiation (GO:0060113)	4.14094486
15	zinc ion transport (GO:0006829)	4.03461416
16	ketone body metabolic process (GO:1902224)	3.97542784
17	iron ion import (GO:0097286)	3.92522392
18	drug catabolic process (GO:0042737)	3.84456279
19	serotonin metabolic process (GO:0042428)	3.81517973
20	alkaloid metabolic process (GO:0009820)	3.73460238
21	biotin metabolic process (GO:0006768)	3.70017353
22	heme transport (GO:0015886)	3.62898974
23	protein carboxylation (GO:0018214)	3.59876678
24	peptidyl-glutamic acid carboxylation (GO:0017187)	3.59876678
25	interkinetic nuclear migration (GO:0022027)	3.59095769
26	response to parathyroid hormone (GO:0071107)	3.58385039
27	establishment of epithelial cell polarity (GO:0090162)	3.57307514
28	short-chain fatty acid metabolic process (GO:0046459)	3.56577038
29	vascular smooth muscle contraction (GO:0014829)	3.54038212
30	blood coagulation, intrinsic pathway (GO:0007597)	3.53354781
31	indolalkylamine metabolic process (GO:0006586)	3.52730654
32	Leydig cell differentiation (GO:0033327)	3.52098808
33	linoleic acid metabolic process (GO:0043651)	3.51341716
34	drug transport (GO:0015893)	3.46549360
35	drug transmembrane transport (GO:0006855)	3.44761097
36	branched-chain amino acid catabolic process (GO:0009083)	3.42704894
37	dopamine biosynthetic process (GO:0042416)	3.42023778
38	omega-hydroxylase P450 pathway (GO:0097267)	3.41700903
39	nucleoside diphosphate catabolic process (GO:0009134)	3.36368257
40	neural tube formation (GO:0001841)	3.34555707
41	regulation of steroid hormone secretion (GO:2000831)	3.33862330
42	phenol-containing compound catabolic process (GO:0019336)	3.33599589
43	toxin metabolic process (GO:0009404)	3.30966892
44	preassembly of GPI anchor in ER membrane (GO:0016254)	3.22066160
45	regulation of macrophage chemotaxis (GO:0010758)	3.19684214
46	cerebral cortex radially oriented cell migration (GO:0021799)	3.17385604
47	indole-containing compound metabolic process (GO:0042430)	3.11364479
48	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.11050103
49	benzene-containing compound metabolic process (GO:0042537)	3.10832873
50	SMAD protein complex assembly (GO:0007183)	3.09925610
51	bile acid biosynthetic process (GO:0006699)	3.09469962
52	artery development (GO:0060840)	3.07974575
53	energy homeostasis (GO:0097009)	3.06437306
54	L-phenylalanine catabolic process (GO:0006559)	3.04274650
55	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.04274650
56	exogenous drug catabolic process (GO:0042738)	3.03639933
57	branched-chain amino acid metabolic process (GO:0009081)	2.98337194
58	negative regulation of response to food (GO:0032096)	2.94985065
59	negative regulation of appetite (GO:0032099)	2.94985065
60	detection of calcium ion (GO:0005513)	2.90245463
61	aromatic amino acid family catabolic process (GO:0009074)	2.89966804
62	brain morphogenesis (GO:0048854)	2.88407296
63	establishment of protein localization to Golgi (GO:0072600)	2.84816940
64	quinone biosynthetic process (GO:1901663)	2.82149190
65	synaptic vesicle maturation (GO:0016188)	2.81057791
66	ubiquinone biosynthetic process (GO:0006744)	2.79906787
67	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.79083693
68	indole-containing compound catabolic process (GO:0042436)	2.77248719
69	indolalkylamine catabolic process (GO:0046218)	2.77248719
70	tryptophan catabolic process (GO:0006569)	2.77248719
71	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.76209507
72	positive regulation of granulocyte differentiation (GO:0030854)	2.75809810
73	iron coordination entity transport (GO:1901678)	2.75019535
74	cellular biogenic amine biosynthetic process (GO:0042401)	2.73721638
75	astrocyte development (GO:0014002)	2.68224182
76	nonmotile primary cilium assembly (GO:0035058)	2.67684956
77	sulfation (GO:0051923)	2.63330901
78	GPI anchor biosynthetic process (GO:0006506)	2.63070886
79	branching involved in prostate gland morphogenesis (GO:0060442)	2.62778842
80	behavioral response to ethanol (GO:0048149)	2.61916513
81	negative regulation of catecholamine secretion (GO:0033604)	2.61755417
82	protein targeting to Golgi (GO:0000042)	2.59132143
83	potassium ion export (GO:0071435)	2.58691143
84	drug metabolic process (GO:0017144)	2.58471677
85	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.57430166
86	L-phenylalanine metabolic process (GO:0006558)	2.57430166
87	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.57331985
88	mechanoreceptor differentiation (GO:0042490)	2.56592825
89	steroid catabolic process (GO:0006706)	2.56488413
90	piRNA metabolic process (GO:0034587)	2.56324423
91	retinal ganglion cell axon guidance (GO:0031290)	2.55998827
92	vitamin D metabolic process (GO:0042359)	2.55930756
93	interleukin-1-mediated signaling pathway (GO:0070498)	2.55179432
94	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.55028387
95	negative regulation of heart rate (GO:0010459)	2.54839568
96	GPI anchor metabolic process (GO:0006505)	2.54628527
97	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.53792539
98	mitochondrial calcium ion homeostasis (GO:0051560)	2.52974720
99	ubiquinone metabolic process (GO:0006743)	2.52732451
100	bile acid metabolic process (GO:0008206)	2.51189406

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.85569263
2	PIAS1_25552417_ChIP-Seq_VCAP_Human	3.25867023
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.07055133
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.02738557
5	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.58002658
6	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.45435472
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.24705868
8	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.23203002
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20077247
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.17296002
11	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	2.07809191
12	FUS_26573619_Chip-Seq_HEK293_Human	2.05483936
13	EZH2_22144423_ChIP-Seq_EOC_Human	1.94691337
14	HTT_18923047_ChIP-ChIP_STHdh_Human	1.94678264
15	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.90976319
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.88736708
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88044347
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.87061643
19	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.81527830
20	AR_25329375_ChIP-Seq_VCAP_Human	1.78857047
21	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.71560237
22	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.70468329
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.67496350
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66480293
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.66480293
26	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60027160
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.58201234
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57324613
29	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.53061557
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52154145
31	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.49606999
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47949428
33	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.45481391
34	P300_19829295_ChIP-Seq_ESCs_Human	1.44772109
35	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.42451279
36	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.38336460
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.38193999
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37815056
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37513021
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37503585
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.37314308
42	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.37046882
43	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36353509
44	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.34552233
45	STAT1_20625510_ChIP-Seq_HELA_Human	1.33756588
46	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.32290394
47	TCF4_23295773_ChIP-Seq_U87_Human	1.32041809
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30866155
49	RXR_22108803_ChIP-Seq_LS180_Human	1.30176116
50	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.30079425
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.29734743
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28524910
53	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.28253699
54	AR_21909140_ChIP-Seq_LNCAP_Human	1.27238297
55	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.27157674
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25864154
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22774847
58	STAT3_23295773_ChIP-Seq_U87_Human	1.21693776
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21398768
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20114271
61	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.19317392
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18405763
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18405763
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18286801
65	VDR_22108803_ChIP-Seq_LS180_Human	1.17580531
66	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.17561265
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15981444
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15355733
69	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.15221368
70	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.15221368
71	ZNF263_19887448_ChIP-Seq_K562_Human	1.15152527
72	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.14925503
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14054476
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12723947
75	IGF1R_20145208_ChIP-Seq_DFB_Human	1.12462356
76	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.08283468
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07895878
78	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07156985
79	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.06891473
80	AR_20517297_ChIP-Seq_VCAP_Human	1.06603041
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05493854
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05419692
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04593786
84	EWS_26573619_Chip-Seq_HEK293_Human	1.04319765
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.04265651
86	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.02326572
87	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.00880769
88	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.00649335
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00603859
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00258281
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00156638
92	ETV1_20927104_ChIP-Seq_GIST48_Human	0.99776892
93	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99224512
94	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98650947
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98569978
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98569978
97	NFYB_21822215_ChIP-Seq_K562_Human	0.98490583
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97078618
99	TBL1_22424771_ChIP-Seq_293T_Human	0.95534708
100	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95240525

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	3.58493530
2	MP0005167_abnormal_blood-brain_barrier	3.37863834
3	MP0005085_abnormal_gallbladder_physiolo	3.31832098
4	MP0002139_abnormal_hepatobiliary_system	3.30730325
5	MP0002822_catalepsy	3.17201570
6	MP0005409_darkened_coat_color	2.88276517
7	MP0004147_increased_porphyrin_level	2.71212535
8	MP0004019_abnormal_vitamin_homeostasis	2.69890967
9	MP0003011_delayed_dark_adaptation	2.69878421
10	MP0002733_abnormal_thermal_nociception	2.63442124
11	MP0003787_abnormal_imprinting	2.49476853
12	MP0002837_dystrophic_cardiac_calcinosis	2.48117015
13	MP0009697_abnormal_copulation	2.33432261
14	MP0001919_abnormal_reproductive_system	2.29722469
15	MP0001485_abnormal_pinna_reflex	2.19835894
16	MP0002234_abnormal_pharynx_morphology	2.19130385
17	MP0008875_abnormal_xenobiotic_pharmacok	2.18559791
18	MP0004742_abnormal_vestibular_system	2.14815729
19	MP0003868_abnormal_feces_composition	2.06810369
20	MP0005360_urolithiasis	2.05321544
21	MP0002163_abnormal_gland_morphology	2.02449665
22	MP0005365_abnormal_bile_salt	1.98271201
23	MP0005379_endocrine/exocrine_gland_phen	1.96640442
24	MP0005551_abnormal_eye_electrophysiolog	1.93788275
25	MP0003879_abnormal_hair_cell	1.93065492
26	MP0001501_abnormal_sleep_pattern	1.92763170
27	MP0002009_preneoplasia	1.89341410
28	MP0003880_abnormal_central_pattern	1.85640762
29	MP0002736_abnormal_nociception_after	1.70207579
30	MP0002166_altered_tumor_susceptibility	1.68984427
31	MP0001970_abnormal_pain_threshold	1.61084166
32	MP0004043_abnormal_pH_regulation	1.60102949
33	MP0004145_abnormal_muscle_electrophysio	1.58750359
34	MP0000383_abnormal_hair_follicle	1.57224902
35	MP0002938_white_spotting	1.54824108
36	MP0005636_abnormal_mineral_homeostasis	1.49855661
37	MP0009780_abnormal_chondrocyte_physiolo	1.47094845
38	MP0001764_abnormal_homeostasis	1.40112783
39	MP0001486_abnormal_startle_reflex	1.38398289
40	MP0002557_abnormal_social/conspecific_i	1.37946227
41	MP0006072_abnormal_retinal_apoptosis	1.34407783
42	MP0003718_maternal_effect	1.33759044
43	MP0004134_abnormal_chest_morphology	1.31582914
44	MP0005310_abnormal_salivary_gland	1.31459531
45	MP0005332_abnormal_amino_acid	1.31244826
46	MP0004270_analgesia	1.30199736
47	MP0000613_abnormal_salivary_gland	1.28641531
48	MP0001879_abnormal_lymphatic_vessel	1.25708851
49	MP0001968_abnormal_touch/_nociception	1.23616741
50	MP0001905_abnormal_dopamine_level	1.21795847
51	MP0002876_abnormal_thyroid_physiology	1.20812917
52	MP0002735_abnormal_chemical_nociception	1.15102775
53	MP0002572_abnormal_emotion/affect_behav	1.13587552
54	MP0002909_abnormal_adrenal_gland	1.13550125
55	MP0008872_abnormal_physiological_respon	1.13381899
56	MP0008877_abnormal_DNA_methylation	1.11997087
57	MP0001765_abnormal_ion_homeostasis	1.09548035
58	MP0000013_abnormal_adipose_tissue	1.09100662
59	MP0002653_abnormal_ependyma_morphology	1.07461259
60	MP0002006_tumorigenesis	1.05340590
61	MP0000631_abnormal_neuroendocrine_gland	0.99879616
62	MP0003315_abnormal_perineum_morphology	0.99546133
63	MP0001666_abnormal_nutrient_absorption	0.98517628
64	MP0003633_abnormal_nervous_system	0.96465448
65	MP0005220_abnormal_exocrine_pancreas	0.95850259
66	MP0005389_reproductive_system_phenotype	0.94289963
67	MP0001664_abnormal_digestion	0.94283661
68	MP0010329_abnormal_lipoprotein_level	0.93926348
69	MP0005330_cardiomyopathy	0.92709291
70	MP0006276_abnormal_autonomic_nervous	0.91512495
71	MP0005253_abnormal_eye_physiology	0.91237770
72	MP0005187_abnormal_penis_morphology	0.89144481
73	MP0002118_abnormal_lipid_homeostasis	0.89014576
74	MP0003136_yellow_coat_color	0.88956776
75	MP0005395_other_phenotype	0.88426882
76	MP0000230_abnormal_systemic_arterial	0.88171166
77	MP0005645_abnormal_hypothalamus_physiol	0.86227534
78	MP0004264_abnormal_extraembryonic_tissu	0.85635567
79	MP0002160_abnormal_reproductive_system	0.85343431
80	MP0003638_abnormal_response/metabolism_	0.85061168
81	MP0003191_abnormal_cellular_cholesterol	0.83163809
82	MP0010386_abnormal_urinary_bladder	0.82982540
83	MP0002067_abnormal_sensory_capabilities	0.81912093
84	MP0000538_abnormal_urinary_bladder	0.80192783
85	MP0003656_abnormal_erythrocyte_physiolo	0.79386848
86	MP0009745_abnormal_behavioral_response	0.76087642
87	MP0001873_stomach_inflammation	0.74588336
88	MP0001529_abnormal_vocalization	0.73468668
89	MP0003953_abnormal_hormone_level	0.73407001
90	MP0002063_abnormal_learning/memory/cond	0.72270369
91	MP0001944_abnormal_pancreas_morphology	0.72003331
92	MP0010678_abnormal_skin_adnexa	0.71046478
93	MP0009642_abnormal_blood_homeostasis	0.70886373
94	MP0001756_abnormal_urination	0.68094854
95	MP0000372_irregular_coat_pigmentation	0.67593371
96	MP0005535_abnormal_body_temperature	0.65972105
97	MP0004924_abnormal_behavior	0.64075533
98	MP0005386_behavior/neurological_phenoty	0.64075533
99	MP0005464_abnormal_platelet_physiology	0.63975213
100	MP0002127_abnormal_cardiovascular_syste	0.62458448

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	4.63377468
2	Hyperventilation (HP:0002883)	4.36214148
3	Abnormality of the axillary hair (HP:0100134)	4.18632266
4	Abnormality of secondary sexual hair (HP:0009888)	4.18632266
5	Intrahepatic cholestasis (HP:0001406)	4.17415904
6	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.09973889
7	Amelogenesis imperfecta (HP:0000705)	3.77300925
8	Congenital, generalized hypertrichosis (HP:0004540)	3.58295677
9	Joint hemorrhage (HP:0005261)	3.56158980
10	Prostate neoplasm (HP:0100787)	3.53722987
11	Epileptic encephalopathy (HP:0200134)	3.48875468
12	Spontaneous abortion (HP:0005268)	3.42028880
13	Neoplasm of the heart (HP:0100544)	3.37613477
14	Limb hypertonia (HP:0002509)	3.32493498
15	Absent speech (HP:0001344)	3.26323218
16	Ketoacidosis (HP:0001993)	3.22970285
17	Congenital sensorineural hearing impairment (HP:0008527)	3.22199558
18	Gonadotropin excess (HP:0000837)	3.20744159
19	Gingival bleeding (HP:0000225)	3.19505692
20	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.12590428
21	Oligodactyly (hands) (HP:0001180)	3.05661960
22	Pancreatic fibrosis (HP:0100732)	2.95038583
23	Bile duct proliferation (HP:0001408)	2.92838058
24	Abnormal biliary tract physiology (HP:0012439)	2.92838058
25	Anal stenosis (HP:0002025)	2.89829142
26	Short tibia (HP:0005736)	2.73989811
27	Chronic hepatic failure (HP:0100626)	2.72494431
28	Absent hand (HP:0004050)	2.69652929
29	Conjugated hyperbilirubinemia (HP:0002908)	2.64986854
30	3-Methylglutaconic aciduria (HP:0003535)	2.60658450
31	Status epilepticus (HP:0002133)	2.60649756
32	Ketosis (HP:0001946)	2.57666483
33	Abnormality of the renal cortex (HP:0011035)	2.53656240
34	Fair hair (HP:0002286)	2.48072594
35	Constricted visual fields (HP:0001133)	2.47097218
36	Abnormality of the prostate (HP:0008775)	2.38971085
37	Deep venous thrombosis (HP:0002625)	2.37961449
38	Testicular atrophy (HP:0000029)	2.37265728
39	Menorrhagia (HP:0000132)	2.37261161
40	Medial flaring of the eyebrow (HP:0010747)	2.35521994
41	Curly hair (HP:0002212)	2.32167036
42	Ankle clonus (HP:0011448)	2.31014740
43	Poor suck (HP:0002033)	2.28126387
44	Gaze-evoked nystagmus (HP:0000640)	2.28090896
45	Prolonged bleeding time (HP:0003010)	2.26287025
46	Hypothermia (HP:0002045)	2.23653584
47	Syncope (HP:0001279)	2.22845808
48	Abnormality of midbrain morphology (HP:0002418)	2.21095244
49	Molar tooth sign on MRI (HP:0002419)	2.21095244
50	Delayed CNS myelination (HP:0002188)	2.20799007
51	Attenuation of retinal blood vessels (HP:0007843)	2.20657607
52	Menstrual irregularities (HP:0000858)	2.20622081
53	Abnormality of fatty-acid metabolism (HP:0004359)	2.19185302
54	Sensorimotor neuropathy (HP:0007141)	2.18421689
55	True hermaphroditism (HP:0010459)	2.17981952
56	Wide intermamillary distance (HP:0006610)	2.16673927
57	Blue irides (HP:0000635)	2.14156854
58	Hyperglycinuria (HP:0003108)	2.13381550
59	Generalized hypopigmentation of hair (HP:0011358)	2.10876932
60	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.09668507
61	Drooling (HP:0002307)	2.08078041
62	Renal cortical cysts (HP:0000803)	2.07459642
63	Pancreatic cysts (HP:0001737)	2.03792399
64	Hyperammonemia (HP:0001987)	2.02336925
65	Metabolic acidosis (HP:0001942)	1.99445054
66	Renal tubular dysfunction (HP:0000124)	1.97056201
67	Choreoathetosis (HP:0001266)	1.92491771
68	Excessive salivation (HP:0003781)	1.92015543
69	Abnormality of the common coagulation pathway (HP:0010990)	1.88568786
70	Tented upper lip vermilion (HP:0010804)	1.88376860
71	Nephronophthisis (HP:0000090)	1.88197540
72	Male pseudohermaphroditism (HP:0000037)	1.87313054
73	Decreased circulating renin level (HP:0003351)	1.86427849
74	Bony spicule pigmentary retinopathy (HP:0007737)	1.85216723
75	Abnormality of glycine metabolism (HP:0010895)	1.85165832
76	Abnormality of serine family amino acid metabolism (HP:0010894)	1.85165832
77	Narrow forehead (HP:0000341)	1.84866651
78	Genetic anticipation (HP:0003743)	1.83997672
79	Decreased subcutaneous fat (HP:0001002)	1.83555661
80	Abnormality of lateral ventricle (HP:0030047)	1.82847568
81	Febrile seizures (HP:0002373)	1.80273201
82	Stomach cancer (HP:0012126)	1.80109190
83	Nuclear cataract (HP:0100018)	1.78065578
84	Abnormality of the renal medulla (HP:0100957)	1.76587158
85	Abnormal urine phosphate concentration (HP:0012599)	1.74522941
86	Testicular neoplasm (HP:0010788)	1.71425982
87	Hypoglycemic coma (HP:0001325)	1.71340756
88	Cystic liver disease (HP:0006706)	1.69970447
89	Increased hepatocellular lipid droplets (HP:0006565)	1.68227124
90	Dialeptic seizures (HP:0011146)	1.64929909
91	Generalized aminoaciduria (HP:0002909)	1.63403024
92	Lipid accumulation in hepatocytes (HP:0006561)	1.62878955
93	Severe muscular hypotonia (HP:0006829)	1.62381877
94	Median cleft lip (HP:0000161)	1.61724305
95	Abnormality of the sella turcica (HP:0002679)	1.60562718
96	Fat malabsorption (HP:0002630)	1.59618532
97	Short phalanx of the thumb (HP:0009660)	1.59614014
98	Intestinal atresia (HP:0011100)	1.58984471
99	Flat acetabular roof (HP:0003180)	1.58868590
100	Abnormal drinking behavior (HP:0030082)	1.57916429

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	5.89831486
2	TNK2	3.80296244
3	CDK8	3.30346383
4	AKT3	3.27529567
5	STK16	3.14508524
6	TGFBR1	2.40414431
7	CAMK1G	2.38609642
8	CAMK1D	2.35175518
9	MAPK13	2.33755788
10	ADRBK2	2.32337569
11	NUAK1	2.21640495
12	CASK	2.13551546
13	GRK1	2.10741040
14	PAK3	2.10065811
15	PIK3CA	1.95216269
16	DAPK2	1.83468883
17	TNIK	1.80207957
18	TAOK1	1.78842640
19	TIE1	1.76567098
20	NME2	1.75006931
21	CCNB1	1.65097875
22	FRK	1.61545924
23	PINK1	1.54834163
24	TRPM7	1.50548921
25	TRIM28	1.50500164
26	WNK4	1.37971457
27	CDK9	1.34043864
28	MINK1	1.28321416
29	BCR	1.27429021
30	TAOK3	1.21236397
31	MYLK	1.21093930
32	PNCK	1.11817745
33	INSRR	1.10543419
34	MAPKAPK3	1.07819641
35	TLK1	1.07543905
36	TESK1	1.07389272
37	DMPK	1.03554783
38	MAP2K6	1.02478668
39	CSNK1G2	0.97586631
40	STK38L	0.97379659
41	MARK1	0.90971174
42	DAPK1	0.90917879
43	YES1	0.86570864
44	PDK1	0.86174374
45	CHUK	0.86100831
46	WNK1	0.81203599
47	CSNK1A1L	0.79365713
48	STK3	0.78735255
49	TEC	0.76272103
50	PIK3CG	0.74223518
51	PRKCG	0.73545035
52	PDPK1	0.71040390
53	BCKDK	0.70609935
54	ADRBK1	0.70237542
55	FER	0.68089287
56	STK39	0.67498621
57	CSNK1G3	0.66905790
58	SGK2	0.63733795
59	PKN1	0.61774845
60	CSNK1G1	0.59914651
61	SGK494	0.58982977
62	SGK223	0.58982977
63	PIM1	0.56193867
64	UHMK1	0.54874524
65	TYRO3	0.53560609
66	MAP4K2	0.53284652
67	WNK3	0.51577233
68	PRKG1	0.49937612
69	ITK	0.49056918
70	ILK	0.48378436
71	ROCK1	0.47375413
72	DAPK3	0.46354894
73	MAP3K12	0.46311825
74	EPHA4	0.45724823
75	OXSR1	0.45107121
76	PRKCQ	0.44251344
77	MAP3K5	0.43969247
78	CAMKK2	0.40584310
79	CDK5	0.40508195
80	MAPK4	0.36521742
81	PTK2B	0.36300046
82	IKBKB	0.35952708
83	PRKACA	0.35239500
84	MARK2	0.33913242
85	PRKCA	0.33395976
86	CSNK1A1	0.33119958
87	BTK	0.33042479
88	ABL1	0.32992131
89	IKBKE	0.32095721
90	CSNK1E	0.30762310
91	IGF1R	0.30666301
92	EIF2AK2	0.29772977
93	LRRK2	0.29053268
94	CDK7	0.28820668
95	SGK1	0.28728943
96	CAMK2A	0.28494168
97	GRK5	0.28158625
98	PRKAA1	0.27446525
99	PRKACG	0.26440886
100	MAPK10	0.25972607

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.42414473
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.62366825
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.17696617
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.11658826
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.88661335
6	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.52078145
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.51819766
8	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.49557417
9	Butanoate metabolism_Homo sapiens_hsa00650	2.41567870
10	Retinol metabolism_Homo sapiens_hsa00830	2.41556931
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.39476369
12	Histidine metabolism_Homo sapiens_hsa00340	2.39413149
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.37801040
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.37129344
15	Chemical carcinogenesis_Homo sapiens_hsa05204	2.34583501
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.26474158
17	Linoleic acid metabolism_Homo sapiens_hsa00591	2.18239257
18	Phenylalanine metabolism_Homo sapiens_hsa00360	2.00119818
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.93503210
20	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.86774697
21	Peroxisome_Homo sapiens_hsa04146	1.79855798
22	ABC transporters_Homo sapiens_hsa02010	1.70822863
23	Sulfur metabolism_Homo sapiens_hsa00920	1.59907928
24	Protein export_Homo sapiens_hsa03060	1.55775145
25	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.48789258
26	Complement and coagulation cascades_Homo sapiens_hsa04610	1.40525666
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32597250
28	Serotonergic synapse_Homo sapiens_hsa04726	1.26746751
29	Bile secretion_Homo sapiens_hsa04976	1.26488840
30	Arginine and proline metabolism_Homo sapiens_hsa00330	1.20151568
31	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.12539669
32	Tyrosine metabolism_Homo sapiens_hsa00350	1.11848992
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.05335466
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.03756765
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.01742750
36	Renin secretion_Homo sapiens_hsa04924	1.00931665
37	Phototransduction_Homo sapiens_hsa04744	0.98991545
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98321370
39	Cocaine addiction_Homo sapiens_hsa05030	0.96663026
40	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.94693714
41	Folate biosynthesis_Homo sapiens_hsa00790	0.94515236
42	Renin-angiotensin system_Homo sapiens_hsa04614	0.91537289
43	Nicotine addiction_Homo sapiens_hsa05033	0.88083122
44	Fatty acid degradation_Homo sapiens_hsa00071	0.87345799
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.86378233
46	Fatty acid elongation_Homo sapiens_hsa00062	0.85988989
47	Propanoate metabolism_Homo sapiens_hsa00640	0.81161419
48	Dopaminergic synapse_Homo sapiens_hsa04728	0.79747213
49	Amphetamine addiction_Homo sapiens_hsa05031	0.79698782
50	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.77594128
51	Prion diseases_Homo sapiens_hsa05020	0.77071525
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.76559027
53	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.75900268
54	Arginine biosynthesis_Homo sapiens_hsa00220	0.73046208
55	Mineral absorption_Homo sapiens_hsa04978	0.66286154
56	Insulin secretion_Homo sapiens_hsa04911	0.63941021
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62545806
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60779815
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60048930
60	Basal transcription factors_Homo sapiens_hsa03022	0.57283983
61	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.54979577
62	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53856108
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53215812
64	PPAR signaling pathway_Homo sapiens_hsa03320	0.52206916
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49174869
66	Olfactory transduction_Homo sapiens_hsa04740	0.48965666
67	Long-term depression_Homo sapiens_hsa04730	0.43319392
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.42777723
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.42416843
70	Choline metabolism in cancer_Homo sapiens_hsa05231	0.39621503
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38510941
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.38389689
73	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.37910262
74	Circadian rhythm_Homo sapiens_hsa04710	0.37812889
75	Circadian entrainment_Homo sapiens_hsa04713	0.37365010
76	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.36379655
77	Metabolic pathways_Homo sapiens_hsa01100	0.35856220
78	Lysine degradation_Homo sapiens_hsa00310	0.35028931
79	Tight junction_Homo sapiens_hsa04530	0.33285429
80	Nitrogen metabolism_Homo sapiens_hsa00910	0.32875408
81	GABAergic synapse_Homo sapiens_hsa04727	0.32083226
82	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.31948020
83	Morphine addiction_Homo sapiens_hsa05032	0.31788212
84	Salivary secretion_Homo sapiens_hsa04970	0.30974908
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.30676471
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.30306673
87	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28870150
88	Type I diabetes mellitus_Homo sapiens_hsa04940	0.26567307
89	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.26471964
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.24172992
91	Alzheimers disease_Homo sapiens_hsa05010	0.22705284
92	Alcoholism_Homo sapiens_hsa05034	0.20726645
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20672647
94	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.20085871
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.19665890
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.19573542
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.18143903
98	Glutathione metabolism_Homo sapiens_hsa00480	0.18031936
99	Asthma_Homo sapiens_hsa05310	0.15936799
100	Hepatitis C_Homo sapiens_hsa05160	0.15883569

GLYATL1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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