GLYATL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)6.97699478
2Rap protein signal transduction (GO:0032486)6.46980735
3amine catabolic process (GO:0009310)5.99930714
4cellular biogenic amine catabolic process (GO:0042402)5.99930714
5chemosensory behavior (GO:0007635)5.89565467
6positive regulation of cell size (GO:0045793)5.61452218
7keratinocyte development (GO:0003334)5.55822785
8protein K11-linked deubiquitination (GO:0035871)5.34964716
9negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.28023043
10protein neddylation (GO:0045116)4.95013888
11regulation of lipoprotein metabolic process (GO:0050746)4.84177730
12positive regulation of protein autophosphorylation (GO:0031954)4.69627490
13polyamine biosynthetic process (GO:0006596)4.64250092
14G-protein coupled receptor internalization (GO:0002031)4.35979752
15amine biosynthetic process (GO:0009309)4.20372060
16lactate metabolic process (GO:0006089)4.13528376
17cellular biogenic amine biosynthetic process (GO:0042401)4.09240940
18detection of light stimulus involved in sensory perception (GO:0050962)4.07518200
19detection of light stimulus involved in visual perception (GO:0050908)4.07518200
20negative regulation of dendrite development (GO:2000171)4.04647473
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.93371892
22regulation of clathrin-mediated endocytosis (GO:2000369)3.93175883
23fibroblast migration (GO:0010761)3.86127943
24platelet aggregation (GO:0070527)3.82688754
25positive regulation of p38MAPK cascade (GO:1900745)3.78524187
26L-fucose catabolic process (GO:0042355)3.69566048
27fucose catabolic process (GO:0019317)3.69566048
28L-fucose metabolic process (GO:0042354)3.69566048
29indole-containing compound catabolic process (GO:0042436)3.67775075
30indolalkylamine catabolic process (GO:0046218)3.67775075
31tryptophan catabolic process (GO:0006569)3.67775075
32protein K6-linked ubiquitination (GO:0085020)3.65892696
33negative regulation of JUN kinase activity (GO:0043508)3.65765408
34retinal cone cell development (GO:0046549)3.56880390
35regulation of memory T cell differentiation (GO:0043380)3.51295071
36single strand break repair (GO:0000012)3.49675526
37limb bud formation (GO:0060174)3.43183250
38glycerophospholipid catabolic process (GO:0046475)3.42177722
39negative regulation of epithelial to mesenchymal transition (GO:0010719)3.40075459
40negative regulation of norepinephrine secretion (GO:0010700)3.32413508
41otic vesicle formation (GO:0030916)3.29897160
42polyamine metabolic process (GO:0006595)3.28951580
43benzene-containing compound metabolic process (GO:0042537)3.28173718
44purine nucleotide transport (GO:0015865)3.19433912
45high-density lipoprotein particle remodeling (GO:0034375)3.18949668
46notochord development (GO:0030903)3.14672853
47aromatic amino acid family catabolic process (GO:0009074)3.14485324
48photoreceptor cell differentiation (GO:0046530)3.13973957
49eye photoreceptor cell differentiation (GO:0001754)3.13973957
50phasic smooth muscle contraction (GO:0014821)3.12237171
51negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.12133196
52ephrin receptor signaling pathway (GO:0048013)3.05197675
53sensory perception of smell (GO:0007608)3.04980231
54cardiac epithelial to mesenchymal transition (GO:0060317)3.00176032
55kynurenine metabolic process (GO:0070189)3.00061586
56reverse cholesterol transport (GO:0043691)2.98655521
57S-adenosylmethionine metabolic process (GO:0046500)2.93935654
58phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.89452250
59regulation of neurotransmitter uptake (GO:0051580)2.88418874
60ovulation from ovarian follicle (GO:0001542)2.84105855
61indolalkylamine metabolic process (GO:0006586)2.83771468
62response to redox state (GO:0051775)2.82912414
63heart valve morphogenesis (GO:0003179)2.81727388
64negative regulation of transcription regulatory region DNA binding (GO:2000678)2.81412293
65regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.79247035
66negative regulation of smooth muscle cell migration (GO:0014912)2.77941028
67regulation of interleukin-8 biosynthetic process (GO:0045414)2.77832158
68establishment of skin barrier (GO:0061436)2.77494791
69phosphatidylcholine acyl-chain remodeling (GO:0036151)2.72777579
70autophagic vacuole fusion (GO:0000046)2.72555539
71T cell apoptotic process (GO:0070231)2.72298977
72tryptophan metabolic process (GO:0006568)2.70384596
73regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.69304213
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68629810
75protein K63-linked deubiquitination (GO:0070536)2.67825843
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.65096598
77negative regulation of mast cell activation (GO:0033004)2.64871146
78homotypic cell-cell adhesion (GO:0034109)2.64552608
79regulation of triglyceride catabolic process (GO:0010896)2.60341421
80linoleic acid metabolic process (GO:0043651)2.59001841
81tonic smooth muscle contraction (GO:0014820)2.58417508
82regulation of Golgi to plasma membrane protein transport (GO:0042996)2.56688430
83regulation of phospholipid biosynthetic process (GO:0071071)2.54542680
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.54534354
85L-phenylalanine catabolic process (GO:0006559)2.54534354
86regulation of endothelial cell differentiation (GO:0045601)2.52379295
87regulation of hexokinase activity (GO:1903299)2.51376368
88regulation of glucokinase activity (GO:0033131)2.51376368
89regulation of Rac protein signal transduction (GO:0035020)2.50742643
90thrombin receptor signaling pathway (GO:0070493)2.48540829
91behavioral response to nicotine (GO:0035095)2.47894197
92multicellular organism reproduction (GO:0032504)2.47782654
93phosphatidylinositol 3-kinase signaling (GO:0014065)2.46412283
94lymphocyte apoptotic process (GO:0070227)2.46105596
95positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.44920538
96negative regulation of protein localization to cell surface (GO:2000009)2.44827393
97organelle membrane fusion (GO:0090174)2.44776717
98negative regulation of alpha-beta T cell differentiation (GO:0046639)2.41629154
99arginine catabolic process (GO:0006527)2.40472246
100negative regulation of T-helper cell differentiation (GO:0045623)2.39661186

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human3.50903283
2ESR1_20079471_ChIP-ChIP_T-47D_Human2.96270069
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.85530885
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.76925160
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.71110433
6VDR_22108803_ChIP-Seq_LS180_Human2.62464538
7ZNF217_24962896_ChIP-Seq_MCF-7_Human2.56022952
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.29608271
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22433877
10GBX2_23144817_ChIP-Seq_PC3_Human2.20204973
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.19194164
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06875080
13ER_23166858_ChIP-Seq_MCF-7_Human1.91976746
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80078143
15TP63_19390658_ChIP-ChIP_HaCaT_Human1.79470823
16TCF4_18268006_ChIP-ChIP_LS174T_Human1.78453973
17CJUN_26792858_Chip-Seq_BT549_Human1.74410930
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.71594277
19* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70239043
20TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68609462
21EZH2_27294783_Chip-Seq_NPCs_Mouse1.65580573
22FOXM1_26456572_ChIP-Seq_MCF-7_Human1.65225906
23EWS_26573619_Chip-Seq_HEK293_Human1.63678304
24ZNF274_21170338_ChIP-Seq_K562_Hela1.58533754
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.57881715
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.57329677
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56178647
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.55480037
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53907220
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53850974
31GATA4_25053715_ChIP-Seq_YYC3_Human1.52310993
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52291709
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52291709
34P300_19829295_ChIP-Seq_ESCs_Human1.51228421
35CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.49598381
36FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.49411208
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.48926980
38E2F1_18555785_Chip-Seq_ESCs_Mouse1.48326401
39RXR_22108803_ChIP-Seq_LS180_Human1.47895768
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46968660
41BCAT_22108803_ChIP-Seq_LS180_Human1.46451601
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43965221
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.43931036
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.42799505
45P53_22387025_ChIP-Seq_ESCs_Mouse1.41607597
46RNF2_27304074_Chip-Seq_NSC_Mouse1.40609053
47TAF15_26573619_Chip-Seq_HEK293_Human1.40388188
48SOX2_19829295_ChIP-Seq_ESCs_Human1.40190763
49NANOG_19829295_ChIP-Seq_ESCs_Human1.40190763
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39798153
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.39192267
52CDX2_22108803_ChIP-Seq_LS180_Human1.39184906
53AHR_22903824_ChIP-Seq_MCF-7_Human1.36286746
54GATA6_21074721_ChIP-Seq_CACO-2_Human1.36189553
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35203283
56AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.35159220
57HOXB7_26014856_ChIP-Seq_BT474_Human1.33776263
58RBPJ_21746931_ChIP-Seq_IB4_Human1.32549483
59PHF8_20622853_ChIP-Seq_HELA_Human1.32467721
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30206477
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29581294
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.29534475
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29420701
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29420701
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29275894
66TBL1_22424771_ChIP-Seq_293T_Human1.28394394
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.26586281
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.26579595
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.26288233
70TCF4_22108803_ChIP-Seq_LS180_Human1.26182837
71SOX2_18555785_Chip-Seq_ESCs_Mouse1.25600812
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25506626
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24202802
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24025543
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23639123
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.23080734
77AR_25329375_ChIP-Seq_VCAP_Human1.20353501
78ETV1_20927104_ChIP-Seq_GIST48_Human1.19682308
79TP53_16413492_ChIP-PET_HCT116_Human1.18271668
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18216872
81SMAD4_21799915_ChIP-Seq_A2780_Human1.16241695
82NFYB_21822215_ChIP-Seq_K562_Human1.16191349
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15062464
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14323680
85EZH2_22144423_ChIP-Seq_EOC_Human1.14267372
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13782392
87AR_21572438_ChIP-Seq_LNCaP_Human1.13585087
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.13263727
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13121220
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12992739
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12604691
92FUS_26573619_Chip-Seq_HEK293_Human1.12028787
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.11716904
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11469156
95P300_18555785_Chip-Seq_ESCs_Mouse1.10067409
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.09623071
97FOXA1_25552417_ChIP-Seq_VCAP_Human1.07744312
98SMRT_27268052_Chip-Seq_Bcells_Human1.07396952
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07330578
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06933967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.66447886
2MP0006276_abnormal_autonomic_nervous3.30470904
3MP0003183_abnormal_peptide_metabolism3.28788211
4MP0005464_abnormal_platelet_physiology3.05674327
5MP0002653_abnormal_ependyma_morphology3.03672194
6MP0003315_abnormal_perineum_morphology2.31231739
7MP0002876_abnormal_thyroid_physiology2.30151084
8MP0008872_abnormal_physiological_respon2.24381092
9MP0003950_abnormal_plasma_membrane2.23036454
10MP0009840_abnormal_foam_cell2.15461378
11MP0000566_synostosis2.10458037
12MP0005423_abnormal_somatic_nervous2.03725329
13MP0001873_stomach_inflammation2.03162958
14MP0000613_abnormal_salivary_gland1.98404356
15MP0002938_white_spotting1.97411374
16MP0001485_abnormal_pinna_reflex1.93876515
17MP0001501_abnormal_sleep_pattern1.85584403
18MP0002282_abnormal_trachea_morphology1.81668134
19MP0004019_abnormal_vitamin_homeostasis1.81233479
20MP0005551_abnormal_eye_electrophysiolog1.76670424
21MP0005646_abnormal_pituitary_gland1.73760102
22MP0000230_abnormal_systemic_arterial1.72365712
23MP0009780_abnormal_chondrocyte_physiolo1.71395380
24MP0008004_abnormal_stomach_pH1.71119593
25MP0001502_abnormal_circadian_rhythm1.69241670
26MP0004085_abnormal_heartbeat1.67915163
27MP0008995_early_reproductive_senescence1.65232207
28MP0008877_abnormal_DNA_methylation1.62818545
29MP0002736_abnormal_nociception_after1.53385201
30MP0003718_maternal_effect1.52584414
31MP0002160_abnormal_reproductive_system1.52132124
32MP0005410_abnormal_fertilization1.48994613
33MP0002735_abnormal_chemical_nociception1.47545480
34MP0005187_abnormal_penis_morphology1.46878281
35MP0008057_abnormal_DNA_replication1.44051900
36MP0008875_abnormal_xenobiotic_pharmacok1.41564428
37MP0003638_abnormal_response/metabolism_1.41249063
38MP0001663_abnormal_digestive_system1.40931786
39MP0002638_abnormal_pupillary_reflex1.40865630
40MP0001529_abnormal_vocalization1.39414175
41MP0003755_abnormal_palate_morphology1.38695342
42MP0004264_abnormal_extraembryonic_tissu1.36847773
43MP0001765_abnormal_ion_homeostasis1.26421724
44MP0006138_congestive_heart_failure1.24863659
45MP0003787_abnormal_imprinting1.24513976
46MP0002102_abnormal_ear_morphology1.23457061
47MP0000647_abnormal_sebaceous_gland1.23005126
48MP0004142_abnormal_muscle_tone1.22362166
49MP0001756_abnormal_urination1.20427609
50MP0005377_hearing/vestibular/ear_phenot1.17486872
51MP0003878_abnormal_ear_physiology1.17486872
52MP0005083_abnormal_biliary_tract1.16088316
53MP0005647_abnormal_sex_gland1.12013374
54MP0002557_abnormal_social/conspecific_i1.10781403
55MP0002277_abnormal_respiratory_mucosa1.10083778
56MP0003724_increased_susceptibility_to1.09553266
57MP0003828_pulmonary_edema1.07414957
58MP0002295_abnormal_pulmonary_circulatio1.06915127
59MP0008058_abnormal_DNA_repair1.03158319
60MP0001666_abnormal_nutrient_absorption1.00249126
61MP0005381_digestive/alimentary_phenotyp0.99721966
62MP0002972_abnormal_cardiac_muscle0.97476208
63MP0003123_paternal_imprinting0.96672326
64MP0002909_abnormal_adrenal_gland0.94383298
65MP0000538_abnormal_urinary_bladder0.93535301
66MP0005389_reproductive_system_phenotype0.88636234
67MP0008789_abnormal_olfactory_epithelium0.87654646
68MP0005395_other_phenotype0.87449053
69MP0005636_abnormal_mineral_homeostasis0.82462861
70MP0000427_abnormal_hair_cycle0.82256155
71MP0005620_abnormal_muscle_contractility0.78917127
72MP0010386_abnormal_urinary_bladder0.78594957
73MP0004782_abnormal_surfactant_physiolog0.77360752
74MP0000569_abnormal_digit_pigmentation0.76922840
75MP0002233_abnormal_nose_morphology0.76885952
76MP0000534_abnormal_ureter_morphology0.76789395
77MP0003943_abnormal_hepatobiliary_system0.76580139
78MP0008961_abnormal_basal_metabolism0.75141151
79MP0003136_yellow_coat_color0.74860231
80MP0002136_abnormal_kidney_physiology0.74341957
81MP0002163_abnormal_gland_morphology0.72699851
82MP0005360_urolithiasis0.71212500
83MP0001851_eye_inflammation0.71136206
84MP0005645_abnormal_hypothalamus_physiol0.70016160
85MP0008775_abnormal_heart_ventricle0.69914791
86MP0000653_abnormal_sex_gland0.69707047
87MP0000470_abnormal_stomach_morphology0.69561351
88MP0001881_abnormal_mammary_gland0.69117587
89MP0004947_skin_inflammation0.68992767
90MP0001968_abnormal_touch/_nociception0.68826191
91MP0005084_abnormal_gallbladder_morpholo0.68660120
92MP0008873_increased_physiological_sensi0.68282317
93MP0005365_abnormal_bile_salt0.67629081
94MP0002108_abnormal_muscle_morphology0.66548581
95MP0004084_abnormal_cardiac_muscle0.65431731
96MP0005332_abnormal_amino_acid0.63375068
97MP0001879_abnormal_lymphatic_vessel0.63304961
98MP0009765_abnormal_xenobiotic_induced0.63245738
99MP0000631_abnormal_neuroendocrine_gland0.63223795
100MP0003936_abnormal_reproductive_system0.63149522

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)5.67490211
2Menorrhagia (HP:0000132)4.91547348
3Follicular hyperkeratosis (HP:0007502)4.13352260
4True hermaphroditism (HP:0010459)4.04371163
5Prolonged bleeding time (HP:0003010)4.02437200
6Genetic anticipation (HP:0003743)3.99465416
7Stomach cancer (HP:0012126)3.95280215
8Congenital, generalized hypertrichosis (HP:0004540)3.76787440
9Progressive cerebellar ataxia (HP:0002073)3.56714303
10Prostate neoplasm (HP:0100787)3.39894120
11Alopecia of scalp (HP:0002293)3.36364202
12Increased mean platelet volume (HP:0011877)3.34283134
13Breast carcinoma (HP:0003002)3.33741912
14Gaze-evoked nystagmus (HP:0000640)3.30145830
15Hyperlipoproteinemia (HP:0010980)3.13640213
16Molar tooth sign on MRI (HP:0002419)3.03224253
17Abnormality of midbrain morphology (HP:0002418)3.03224253
18Pancreatic fibrosis (HP:0100732)3.01644671
19Pancreatic cysts (HP:0001737)2.99418166
20Stenosis of the external auditory canal (HP:0000402)2.98549356
21Abnormal platelet volume (HP:0011876)2.92179769
22Abnormality of the pons (HP:0007361)2.87612606
23Congenital stationary night blindness (HP:0007642)2.85022281
24Abnormality of the prostate (HP:0008775)2.74831015
25Purpura (HP:0000979)2.72283346
26Microretrognathia (HP:0000308)2.70676230
27Abnormality of the renal cortex (HP:0011035)2.70422306
28Abnormality of the nasal septum (HP:0000419)2.66038723
29Male pseudohermaphroditism (HP:0000037)2.65865782
30Severe visual impairment (HP:0001141)2.64412001
31Type II lissencephaly (HP:0007260)2.62261087
32Cystic liver disease (HP:0006706)2.60594673
33Sparse eyelashes (HP:0000653)2.60392587
34Tubular atrophy (HP:0000092)2.48468451
35Epistaxis (HP:0000421)2.45696368
36Optic nerve hypoplasia (HP:0000609)2.41406647
37Dysdiadochokinesis (HP:0002075)2.40093239
38Depressed nasal tip (HP:0000437)2.38831262
39Abnormality of the labia minora (HP:0012880)2.38445975
40Lissencephaly (HP:0001339)2.37935533
41Febrile seizures (HP:0002373)2.37777349
42Hypomagnesemia (HP:0002917)2.37672325
43Ectropion (HP:0000656)2.37182794
44Nephronophthisis (HP:0000090)2.31864761
45Hypoplasia of the pons (HP:0012110)2.28213961
46Urinary bladder sphincter dysfunction (HP:0002839)2.27874741
47Abnormality of male internal genitalia (HP:0000022)2.27160487
48Abolished electroretinogram (ERG) (HP:0000550)2.23131438
49Pendular nystagmus (HP:0012043)2.21875110
50Renal cortical cysts (HP:0000803)2.21192061
5111 pairs of ribs (HP:0000878)2.20340926
52Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.20136329
53Abnormality of dental color (HP:0011073)2.17118887
54Nausea (HP:0002018)2.15788570
55Back pain (HP:0003418)2.15163959
56Keratoconus (HP:0000563)2.14877846
57Increased corneal curvature (HP:0100692)2.14877846
58Impaired platelet aggregation (HP:0003540)2.14261773
59Abnormal platelet function (HP:0011869)2.14261773
60Abnormality of lateral ventricle (HP:0030047)2.14013204
61Concave nail (HP:0001598)2.13787795
62Hypoplastic labia majora (HP:0000059)2.13504212
63Abnormal rod and cone electroretinograms (HP:0008323)2.12443108
64Abnormality of the renal medulla (HP:0100957)2.09696323
65Abnormality of macular pigmentation (HP:0008002)2.09688182
66Median cleft lip (HP:0000161)2.08574101
67Respiratory distress (HP:0002098)2.06526896
68Decreased central vision (HP:0007663)2.05408490
69Chronic hepatic failure (HP:0100626)2.05052499
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04038583
71Alveolar cell carcinoma (HP:0006519)2.03539363
72Chorioretinal atrophy (HP:0000533)2.03269452
73Arthropathy (HP:0003040)2.01909711
74Azoospermia (HP:0000027)2.01155990
75Pachygyria (HP:0001302)2.00444243
76Cerebellar dysplasia (HP:0007033)1.98690294
77Anophthalmia (HP:0000528)1.96926032
78Woolly hair (HP:0002224)1.95966688
79Rib fusion (HP:0000902)1.94625986
80Rhinitis (HP:0012384)1.94411839
81Hypoplastic iliac wings (HP:0002866)1.93908838
82Polydipsia (HP:0001959)1.90985390
83Abnormal drinking behavior (HP:0030082)1.90985390
84Atonic seizures (HP:0010819)1.88495644
85Abnormal respiratory motile cilium physiology (HP:0012261)1.88456082
86Glossoptosis (HP:0000162)1.88415457
87Abnormality of the labia majora (HP:0012881)1.86549530
88Inability to walk (HP:0002540)1.85264540
89Acute encephalopathy (HP:0006846)1.83298408
90Absent/shortened dynein arms (HP:0200106)1.83173971
91Dynein arm defect of respiratory motile cilia (HP:0012255)1.83173971
92Lip pit (HP:0100267)1.82912182
93Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82795404
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81964363
95Joint hemorrhage (HP:0005261)1.81860756
96Hyperglycinuria (HP:0003108)1.81719091
97Polyuria (HP:0000103)1.81217508
98Duplicated collecting system (HP:0000081)1.80187103
99Hyperglycinemia (HP:0002154)1.79850031
100Occipital encephalocele (HP:0002085)1.79723639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.56373065
2EPHA25.46486901
3BRSK25.39017089
4WEE14.06117936
5GRK13.97424211
6STK38L2.73631093
7TRIM282.50761707
8CASK1.96956363
9PIK3CG1.95832422
10ADRBK21.91039499
11BRSK11.85379505
12DYRK31.75894750
13BCR1.66057067
14MYLK1.57424393
15MAP3K121.57011853
16IKBKB1.45031070
17MKNK21.44961452
18STK31.41787931
19TAOK31.33341378
20SIK31.29761443
21PAK31.26901683
22PTK2B1.25986114
23NUAK11.25032785
24LATS11.24587173
25TNK21.17257844
26TEC1.12261418
27ZAK1.09004859
28TNIK1.07647455
29WNK31.07038971
30MAP3K41.06766431
31FRK1.05936450
32WNK41.05782434
33TAOK11.04127722
34STK391.03668034
35MUSK0.99456982
36FER0.96172974
37PNCK0.91846798
38MAP3K30.85283640
39CAMK1D0.84556536
40STK380.82952928
41BMX0.77445269
42CAMK1G0.74856489
43TLK10.73302395
44AKT30.72013925
45PRKCI0.70129513
46BMPR20.68927849
47PRKCG0.65663234
48BTK0.64075687
49MAP4K20.60166227
50MAPK130.58362098
51IRAK10.57988867
52SGK20.56399560
53MAP2K10.56207630
54ADRBK10.56124887
55LRRK20.55248712
56ABL20.54880707
57TSSK60.53081843
58GRK50.52056612
59BCKDK0.51290041
60PIM20.50501005
61PRKCE0.49616507
62MKNK10.48851609
63DYRK1A0.47416521
64BMPR1B0.45625746
65MINK10.43771387
66ILK0.41701554
67ROCK10.41044196
68CHUK0.40434168
69ERBB20.39613361
70OXSR10.39116723
71PIK3CA0.38510975
72DYRK20.36364740
73CSNK1A10.33204065
74IGF1R0.32780925
75CSF1R0.30132241
76PRKCA0.28450113
77EGFR0.28391159
78MET0.28001681
79PAK10.27582980
80CSNK1D0.24710496
81CSNK1E0.24521830
82AKT10.24512869
83PLK20.23535524
84MAPK150.23126706
85SGK30.22422422
86PRKACA0.21422102
87MAPKAPK30.21386018
88PRKCQ0.21173244
89MATK0.19425667
90ITK0.19304920
91PRKAA20.18894666
92MARK30.18394381
93EIF2AK10.17573948
94PRKACG0.17411790
95SGK2230.17284694
96SGK4940.17284694
97ACVR1B0.16542087
98ABL10.16244667
99EPHB20.15935679
100CSNK2A10.15809987

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.58347482
2Nitrogen metabolism_Homo sapiens_hsa009103.46713616
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.08440984
4Linoleic acid metabolism_Homo sapiens_hsa005912.66916924
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.48796628
6Phototransduction_Homo sapiens_hsa047442.48413629
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.45487735
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.44056685
9Sulfur metabolism_Homo sapiens_hsa009202.32443403
10Circadian rhythm_Homo sapiens_hsa047101.96213116
11Selenocompound metabolism_Homo sapiens_hsa004501.95627184
12Butanoate metabolism_Homo sapiens_hsa006501.75385674
13Mineral absorption_Homo sapiens_hsa049781.74455405
14Platelet activation_Homo sapiens_hsa046111.74209523
15Protein export_Homo sapiens_hsa030601.69119059
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68363397
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66082296
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.61282719
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59194251
20Olfactory transduction_Homo sapiens_hsa047401.56235695
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.53820657
22Arachidonic acid metabolism_Homo sapiens_hsa005901.49811061
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.42921792
24Tryptophan metabolism_Homo sapiens_hsa003801.42251254
25Steroid biosynthesis_Homo sapiens_hsa001001.38407577
26Fatty acid biosynthesis_Homo sapiens_hsa000611.36470477
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.34727628
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34687176
29Ether lipid metabolism_Homo sapiens_hsa005651.22203654
30Vitamin digestion and absorption_Homo sapiens_hsa049771.15259642
31Sulfur relay system_Homo sapiens_hsa041221.12510965
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10349436
33Histidine metabolism_Homo sapiens_hsa003401.09337281
34Chemical carcinogenesis_Homo sapiens_hsa052041.08190633
35beta-Alanine metabolism_Homo sapiens_hsa004101.07963892
36Propanoate metabolism_Homo sapiens_hsa006401.04302032
37ABC transporters_Homo sapiens_hsa020101.04238999
38Retinol metabolism_Homo sapiens_hsa008301.00204200
39Salivary secretion_Homo sapiens_hsa049701.00012607
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99802532
41Sphingolipid metabolism_Homo sapiens_hsa006000.99069833
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96349994
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95818011
44Cocaine addiction_Homo sapiens_hsa050300.95151086
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94746043
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93942980
47ECM-receptor interaction_Homo sapiens_hsa045120.93550732
48Arginine and proline metabolism_Homo sapiens_hsa003300.92673102
49Serotonergic synapse_Homo sapiens_hsa047260.92041906
50Homologous recombination_Homo sapiens_hsa034400.91683612
51Fat digestion and absorption_Homo sapiens_hsa049750.89064032
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88027943
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87782629
54Glycerolipid metabolism_Homo sapiens_hsa005610.86101615
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80357500
56Fanconi anemia pathway_Homo sapiens_hsa034600.73879867
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.70618205
58Taste transduction_Homo sapiens_hsa047420.68084124
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65066530
60Oxidative phosphorylation_Homo sapiens_hsa001900.63132104
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62882241
62Basal transcription factors_Homo sapiens_hsa030220.61592753
63Morphine addiction_Homo sapiens_hsa050320.60570482
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60405277
65Dorso-ventral axis formation_Homo sapiens_hsa043200.60105337
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59185386
67Circadian entrainment_Homo sapiens_hsa047130.59029091
68PPAR signaling pathway_Homo sapiens_hsa033200.58014848
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57665626
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56297507
71Dopaminergic synapse_Homo sapiens_hsa047280.56186530
72Chemokine signaling pathway_Homo sapiens_hsa040620.54259000
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52327928
74Ovarian steroidogenesis_Homo sapiens_hsa049130.50606055
75Hematopoietic cell lineage_Homo sapiens_hsa046400.48646475
76Purine metabolism_Homo sapiens_hsa002300.47719550
77Tight junction_Homo sapiens_hsa045300.45580130
78Cholinergic synapse_Homo sapiens_hsa047250.45291385
79Hedgehog signaling pathway_Homo sapiens_hsa043400.43916454
80Tyrosine metabolism_Homo sapiens_hsa003500.43619420
81Calcium signaling pathway_Homo sapiens_hsa040200.41999294
82Mismatch repair_Homo sapiens_hsa034300.41871367
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.41733619
84cAMP signaling pathway_Homo sapiens_hsa040240.40375316
85Pancreatic secretion_Homo sapiens_hsa049720.39916912
86T cell receptor signaling pathway_Homo sapiens_hsa046600.38233185
87Parkinsons disease_Homo sapiens_hsa050120.37402468
88Prostate cancer_Homo sapiens_hsa052150.37113383
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36911952
90Amphetamine addiction_Homo sapiens_hsa050310.36451905
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.35550049
92Regulation of autophagy_Homo sapiens_hsa041400.33534344
93Hippo signaling pathway_Homo sapiens_hsa043900.33087251
94RNA polymerase_Homo sapiens_hsa030200.32300245
95Ras signaling pathway_Homo sapiens_hsa040140.32144326
96Collecting duct acid secretion_Homo sapiens_hsa049660.32123880
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31151572
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30775438
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29960793
100Hepatitis C_Homo sapiens_hsa051600.29104520

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