Rank | Gene Set | Z-score |
---|---|---|
1 | negative regulation of dendrite morphogenesis (GO:0050774) | 6.97699478 |
2 | Rap protein signal transduction (GO:0032486) | 6.46980735 |
3 | amine catabolic process (GO:0009310) | 5.99930714 |
4 | cellular biogenic amine catabolic process (GO:0042402) | 5.99930714 |
5 | chemosensory behavior (GO:0007635) | 5.89565467 |
6 | positive regulation of cell size (GO:0045793) | 5.61452218 |
7 | keratinocyte development (GO:0003334) | 5.55822785 |
8 | protein K11-linked deubiquitination (GO:0035871) | 5.34964716 |
9 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 5.28023043 |
10 | protein neddylation (GO:0045116) | 4.95013888 |
11 | regulation of lipoprotein metabolic process (GO:0050746) | 4.84177730 |
12 | positive regulation of protein autophosphorylation (GO:0031954) | 4.69627490 |
13 | polyamine biosynthetic process (GO:0006596) | 4.64250092 |
14 | G-protein coupled receptor internalization (GO:0002031) | 4.35979752 |
15 | amine biosynthetic process (GO:0009309) | 4.20372060 |
16 | lactate metabolic process (GO:0006089) | 4.13528376 |
17 | cellular biogenic amine biosynthetic process (GO:0042401) | 4.09240940 |
18 | detection of light stimulus involved in sensory perception (GO:0050962) | 4.07518200 |
19 | detection of light stimulus involved in visual perception (GO:0050908) | 4.07518200 |
20 | negative regulation of dendrite development (GO:2000171) | 4.04647473 |
21 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.93371892 |
22 | regulation of clathrin-mediated endocytosis (GO:2000369) | 3.93175883 |
23 | fibroblast migration (GO:0010761) | 3.86127943 |
24 | platelet aggregation (GO:0070527) | 3.82688754 |
25 | positive regulation of p38MAPK cascade (GO:1900745) | 3.78524187 |
26 | L-fucose catabolic process (GO:0042355) | 3.69566048 |
27 | fucose catabolic process (GO:0019317) | 3.69566048 |
28 | L-fucose metabolic process (GO:0042354) | 3.69566048 |
29 | indole-containing compound catabolic process (GO:0042436) | 3.67775075 |
30 | indolalkylamine catabolic process (GO:0046218) | 3.67775075 |
31 | tryptophan catabolic process (GO:0006569) | 3.67775075 |
32 | protein K6-linked ubiquitination (GO:0085020) | 3.65892696 |
33 | negative regulation of JUN kinase activity (GO:0043508) | 3.65765408 |
34 | retinal cone cell development (GO:0046549) | 3.56880390 |
35 | regulation of memory T cell differentiation (GO:0043380) | 3.51295071 |
36 | single strand break repair (GO:0000012) | 3.49675526 |
37 | limb bud formation (GO:0060174) | 3.43183250 |
38 | glycerophospholipid catabolic process (GO:0046475) | 3.42177722 |
39 | negative regulation of epithelial to mesenchymal transition (GO:0010719) | 3.40075459 |
40 | negative regulation of norepinephrine secretion (GO:0010700) | 3.32413508 |
41 | otic vesicle formation (GO:0030916) | 3.29897160 |
42 | polyamine metabolic process (GO:0006595) | 3.28951580 |
43 | benzene-containing compound metabolic process (GO:0042537) | 3.28173718 |
44 | purine nucleotide transport (GO:0015865) | 3.19433912 |
45 | high-density lipoprotein particle remodeling (GO:0034375) | 3.18949668 |
46 | notochord development (GO:0030903) | 3.14672853 |
47 | aromatic amino acid family catabolic process (GO:0009074) | 3.14485324 |
48 | photoreceptor cell differentiation (GO:0046530) | 3.13973957 |
49 | eye photoreceptor cell differentiation (GO:0001754) | 3.13973957 |
50 | phasic smooth muscle contraction (GO:0014821) | 3.12237171 |
51 | negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642) | 3.12133196 |
52 | ephrin receptor signaling pathway (GO:0048013) | 3.05197675 |
53 | sensory perception of smell (GO:0007608) | 3.04980231 |
54 | cardiac epithelial to mesenchymal transition (GO:0060317) | 3.00176032 |
55 | kynurenine metabolic process (GO:0070189) | 3.00061586 |
56 | reverse cholesterol transport (GO:0043691) | 2.98655521 |
57 | S-adenosylmethionine metabolic process (GO:0046500) | 2.93935654 |
58 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 2.89452250 |
59 | regulation of neurotransmitter uptake (GO:0051580) | 2.88418874 |
60 | ovulation from ovarian follicle (GO:0001542) | 2.84105855 |
61 | indolalkylamine metabolic process (GO:0006586) | 2.83771468 |
62 | response to redox state (GO:0051775) | 2.82912414 |
63 | heart valve morphogenesis (GO:0003179) | 2.81727388 |
64 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 2.81412293 |
65 | regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664) | 2.79247035 |
66 | negative regulation of smooth muscle cell migration (GO:0014912) | 2.77941028 |
67 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 2.77832158 |
68 | establishment of skin barrier (GO:0061436) | 2.77494791 |
69 | phosphatidylcholine acyl-chain remodeling (GO:0036151) | 2.72777579 |
70 | autophagic vacuole fusion (GO:0000046) | 2.72555539 |
71 | T cell apoptotic process (GO:0070231) | 2.72298977 |
72 | tryptophan metabolic process (GO:0006568) | 2.70384596 |
73 | regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640) | 2.69304213 |
74 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.68629810 |
75 | protein K63-linked deubiquitination (GO:0070536) | 2.67825843 |
76 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 2.65096598 |
77 | negative regulation of mast cell activation (GO:0033004) | 2.64871146 |
78 | homotypic cell-cell adhesion (GO:0034109) | 2.64552608 |
79 | regulation of triglyceride catabolic process (GO:0010896) | 2.60341421 |
80 | linoleic acid metabolic process (GO:0043651) | 2.59001841 |
81 | tonic smooth muscle contraction (GO:0014820) | 2.58417508 |
82 | regulation of Golgi to plasma membrane protein transport (GO:0042996) | 2.56688430 |
83 | regulation of phospholipid biosynthetic process (GO:0071071) | 2.54542680 |
84 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 2.54534354 |
85 | L-phenylalanine catabolic process (GO:0006559) | 2.54534354 |
86 | regulation of endothelial cell differentiation (GO:0045601) | 2.52379295 |
87 | regulation of hexokinase activity (GO:1903299) | 2.51376368 |
88 | regulation of glucokinase activity (GO:0033131) | 2.51376368 |
89 | regulation of Rac protein signal transduction (GO:0035020) | 2.50742643 |
90 | thrombin receptor signaling pathway (GO:0070493) | 2.48540829 |
91 | behavioral response to nicotine (GO:0035095) | 2.47894197 |
92 | multicellular organism reproduction (GO:0032504) | 2.47782654 |
93 | phosphatidylinositol 3-kinase signaling (GO:0014065) | 2.46412283 |
94 | lymphocyte apoptotic process (GO:0070227) | 2.46105596 |
95 | positive regulation of macrophage derived foam cell differentiation (GO:0010744) | 2.44920538 |
96 | negative regulation of protein localization to cell surface (GO:2000009) | 2.44827393 |
97 | organelle membrane fusion (GO:0090174) | 2.44776717 |
98 | negative regulation of alpha-beta T cell differentiation (GO:0046639) | 2.41629154 |
99 | arginine catabolic process (GO:0006527) | 2.40472246 |
100 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.39661186 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 3.50903283 |
2 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 2.96270069 |
3 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 2.85530885 |
4 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.76925160 |
5 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.71110433 |
6 | VDR_22108803_ChIP-Seq_LS180_Human | 2.62464538 |
7 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 2.56022952 |
8 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.29608271 |
9 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.22433877 |
10 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.20204973 |
11 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 2.19194164 |
12 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.06875080 |
13 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.91976746 |
14 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.80078143 |
15 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.79470823 |
16 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.78453973 |
17 | CJUN_26792858_Chip-Seq_BT549_Human | 1.74410930 |
18 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.71594277 |
19 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.70239043 |
20 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.68609462 |
21 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.65580573 |
22 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.65225906 |
23 | EWS_26573619_Chip-Seq_HEK293_Human | 1.63678304 |
24 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.58533754 |
25 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.57881715 |
26 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.57329677 |
27 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.56178647 |
28 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.55480037 |
29 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.53907220 |
30 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.53850974 |
31 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.52310993 |
32 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.52291709 |
33 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.52291709 |
34 | P300_19829295_ChIP-Seq_ESCs_Human | 1.51228421 |
35 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.49598381 |
36 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.49411208 |
37 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.48926980 |
38 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.48326401 |
39 | RXR_22108803_ChIP-Seq_LS180_Human | 1.47895768 |
40 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.46968660 |
41 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.46451601 |
42 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.43965221 |
43 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.43931036 |
44 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.42799505 |
45 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.41607597 |
46 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.40609053 |
47 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.40388188 |
48 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.40190763 |
49 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.40190763 |
50 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.39798153 |
51 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.39192267 |
52 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.39184906 |
53 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.36286746 |
54 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.36189553 |
55 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.35203283 |
56 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.35159220 |
57 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.33776263 |
58 | RBPJ_21746931_ChIP-Seq_IB4_Human | 1.32549483 |
59 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.32467721 |
60 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.30206477 |
61 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.29581294 |
62 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.29534475 |
63 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.29420701 |
64 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.29420701 |
65 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.29275894 |
66 | TBL1_22424771_ChIP-Seq_293T_Human | 1.28394394 |
67 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.26586281 |
68 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.26579595 |
69 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.26288233 |
70 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.26182837 |
71 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.25600812 |
72 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.25506626 |
73 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.24202802 |
74 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.24025543 |
75 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.23639123 |
76 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.23080734 |
77 | AR_25329375_ChIP-Seq_VCAP_Human | 1.20353501 |
78 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.19682308 |
79 | TP53_16413492_ChIP-PET_HCT116_Human | 1.18271668 |
80 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.18216872 |
81 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.16241695 |
82 | NFYB_21822215_ChIP-Seq_K562_Human | 1.16191349 |
83 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.15062464 |
84 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.14323680 |
85 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.14267372 |
86 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.13782392 |
87 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.13585087 |
88 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.13263727 |
89 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.13121220 |
90 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.12992739 |
91 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.12604691 |
92 | FUS_26573619_Chip-Seq_HEK293_Human | 1.12028787 |
93 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.11716904 |
94 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.11469156 |
95 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.10067409 |
96 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.09623071 |
97 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 1.07744312 |
98 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.07396952 |
99 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.07330578 |
100 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.06933967 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005670_abnormal_white_adipose | 4.66447886 |
2 | MP0006276_abnormal_autonomic_nervous | 3.30470904 |
3 | MP0003183_abnormal_peptide_metabolism | 3.28788211 |
4 | MP0005464_abnormal_platelet_physiology | 3.05674327 |
5 | MP0002653_abnormal_ependyma_morphology | 3.03672194 |
6 | MP0003315_abnormal_perineum_morphology | 2.31231739 |
7 | MP0002876_abnormal_thyroid_physiology | 2.30151084 |
8 | MP0008872_abnormal_physiological_respon | 2.24381092 |
9 | MP0003950_abnormal_plasma_membrane | 2.23036454 |
10 | MP0009840_abnormal_foam_cell | 2.15461378 |
11 | MP0000566_synostosis | 2.10458037 |
12 | MP0005423_abnormal_somatic_nervous | 2.03725329 |
13 | MP0001873_stomach_inflammation | 2.03162958 |
14 | MP0000613_abnormal_salivary_gland | 1.98404356 |
15 | MP0002938_white_spotting | 1.97411374 |
16 | MP0001485_abnormal_pinna_reflex | 1.93876515 |
17 | MP0001501_abnormal_sleep_pattern | 1.85584403 |
18 | MP0002282_abnormal_trachea_morphology | 1.81668134 |
19 | MP0004019_abnormal_vitamin_homeostasis | 1.81233479 |
20 | MP0005551_abnormal_eye_electrophysiolog | 1.76670424 |
21 | MP0005646_abnormal_pituitary_gland | 1.73760102 |
22 | MP0000230_abnormal_systemic_arterial | 1.72365712 |
23 | MP0009780_abnormal_chondrocyte_physiolo | 1.71395380 |
24 | MP0008004_abnormal_stomach_pH | 1.71119593 |
25 | MP0001502_abnormal_circadian_rhythm | 1.69241670 |
26 | MP0004085_abnormal_heartbeat | 1.67915163 |
27 | MP0008995_early_reproductive_senescence | 1.65232207 |
28 | MP0008877_abnormal_DNA_methylation | 1.62818545 |
29 | MP0002736_abnormal_nociception_after | 1.53385201 |
30 | MP0003718_maternal_effect | 1.52584414 |
31 | MP0002160_abnormal_reproductive_system | 1.52132124 |
32 | MP0005410_abnormal_fertilization | 1.48994613 |
33 | MP0002735_abnormal_chemical_nociception | 1.47545480 |
34 | MP0005187_abnormal_penis_morphology | 1.46878281 |
35 | MP0008057_abnormal_DNA_replication | 1.44051900 |
36 | MP0008875_abnormal_xenobiotic_pharmacok | 1.41564428 |
37 | MP0003638_abnormal_response/metabolism_ | 1.41249063 |
38 | MP0001663_abnormal_digestive_system | 1.40931786 |
39 | MP0002638_abnormal_pupillary_reflex | 1.40865630 |
40 | MP0001529_abnormal_vocalization | 1.39414175 |
41 | MP0003755_abnormal_palate_morphology | 1.38695342 |
42 | MP0004264_abnormal_extraembryonic_tissu | 1.36847773 |
43 | MP0001765_abnormal_ion_homeostasis | 1.26421724 |
44 | MP0006138_congestive_heart_failure | 1.24863659 |
45 | MP0003787_abnormal_imprinting | 1.24513976 |
46 | MP0002102_abnormal_ear_morphology | 1.23457061 |
47 | MP0000647_abnormal_sebaceous_gland | 1.23005126 |
48 | MP0004142_abnormal_muscle_tone | 1.22362166 |
49 | MP0001756_abnormal_urination | 1.20427609 |
50 | MP0005377_hearing/vestibular/ear_phenot | 1.17486872 |
51 | MP0003878_abnormal_ear_physiology | 1.17486872 |
52 | MP0005083_abnormal_biliary_tract | 1.16088316 |
53 | MP0005647_abnormal_sex_gland | 1.12013374 |
54 | MP0002557_abnormal_social/conspecific_i | 1.10781403 |
55 | MP0002277_abnormal_respiratory_mucosa | 1.10083778 |
56 | MP0003724_increased_susceptibility_to | 1.09553266 |
57 | MP0003828_pulmonary_edema | 1.07414957 |
58 | MP0002295_abnormal_pulmonary_circulatio | 1.06915127 |
59 | MP0008058_abnormal_DNA_repair | 1.03158319 |
60 | MP0001666_abnormal_nutrient_absorption | 1.00249126 |
61 | MP0005381_digestive/alimentary_phenotyp | 0.99721966 |
62 | MP0002972_abnormal_cardiac_muscle | 0.97476208 |
63 | MP0003123_paternal_imprinting | 0.96672326 |
64 | MP0002909_abnormal_adrenal_gland | 0.94383298 |
65 | MP0000538_abnormal_urinary_bladder | 0.93535301 |
66 | MP0005389_reproductive_system_phenotype | 0.88636234 |
67 | MP0008789_abnormal_olfactory_epithelium | 0.87654646 |
68 | MP0005395_other_phenotype | 0.87449053 |
69 | MP0005636_abnormal_mineral_homeostasis | 0.82462861 |
70 | MP0000427_abnormal_hair_cycle | 0.82256155 |
71 | MP0005620_abnormal_muscle_contractility | 0.78917127 |
72 | MP0010386_abnormal_urinary_bladder | 0.78594957 |
73 | MP0004782_abnormal_surfactant_physiolog | 0.77360752 |
74 | MP0000569_abnormal_digit_pigmentation | 0.76922840 |
75 | MP0002233_abnormal_nose_morphology | 0.76885952 |
76 | MP0000534_abnormal_ureter_morphology | 0.76789395 |
77 | MP0003943_abnormal_hepatobiliary_system | 0.76580139 |
78 | MP0008961_abnormal_basal_metabolism | 0.75141151 |
79 | MP0003136_yellow_coat_color | 0.74860231 |
80 | MP0002136_abnormal_kidney_physiology | 0.74341957 |
81 | MP0002163_abnormal_gland_morphology | 0.72699851 |
82 | MP0005360_urolithiasis | 0.71212500 |
83 | MP0001851_eye_inflammation | 0.71136206 |
84 | MP0005645_abnormal_hypothalamus_physiol | 0.70016160 |
85 | MP0008775_abnormal_heart_ventricle | 0.69914791 |
86 | MP0000653_abnormal_sex_gland | 0.69707047 |
87 | MP0000470_abnormal_stomach_morphology | 0.69561351 |
88 | MP0001881_abnormal_mammary_gland | 0.69117587 |
89 | MP0004947_skin_inflammation | 0.68992767 |
90 | MP0001968_abnormal_touch/_nociception | 0.68826191 |
91 | MP0005084_abnormal_gallbladder_morpholo | 0.68660120 |
92 | MP0008873_increased_physiological_sensi | 0.68282317 |
93 | MP0005365_abnormal_bile_salt | 0.67629081 |
94 | MP0002108_abnormal_muscle_morphology | 0.66548581 |
95 | MP0004084_abnormal_cardiac_muscle | 0.65431731 |
96 | MP0005332_abnormal_amino_acid | 0.63375068 |
97 | MP0001879_abnormal_lymphatic_vessel | 0.63304961 |
98 | MP0009765_abnormal_xenobiotic_induced | 0.63245738 |
99 | MP0000631_abnormal_neuroendocrine_gland | 0.63223795 |
100 | MP0003936_abnormal_reproductive_system | 0.63149522 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Petechiae (HP:0000967) | 5.67490211 |
2 | Menorrhagia (HP:0000132) | 4.91547348 |
3 | Follicular hyperkeratosis (HP:0007502) | 4.13352260 |
4 | True hermaphroditism (HP:0010459) | 4.04371163 |
5 | Prolonged bleeding time (HP:0003010) | 4.02437200 |
6 | Genetic anticipation (HP:0003743) | 3.99465416 |
7 | Stomach cancer (HP:0012126) | 3.95280215 |
8 | Congenital, generalized hypertrichosis (HP:0004540) | 3.76787440 |
9 | Progressive cerebellar ataxia (HP:0002073) | 3.56714303 |
10 | Prostate neoplasm (HP:0100787) | 3.39894120 |
11 | Alopecia of scalp (HP:0002293) | 3.36364202 |
12 | Increased mean platelet volume (HP:0011877) | 3.34283134 |
13 | Breast carcinoma (HP:0003002) | 3.33741912 |
14 | Gaze-evoked nystagmus (HP:0000640) | 3.30145830 |
15 | Hyperlipoproteinemia (HP:0010980) | 3.13640213 |
16 | Molar tooth sign on MRI (HP:0002419) | 3.03224253 |
17 | Abnormality of midbrain morphology (HP:0002418) | 3.03224253 |
18 | Pancreatic fibrosis (HP:0100732) | 3.01644671 |
19 | Pancreatic cysts (HP:0001737) | 2.99418166 |
20 | Stenosis of the external auditory canal (HP:0000402) | 2.98549356 |
21 | Abnormal platelet volume (HP:0011876) | 2.92179769 |
22 | Abnormality of the pons (HP:0007361) | 2.87612606 |
23 | Congenital stationary night blindness (HP:0007642) | 2.85022281 |
24 | Abnormality of the prostate (HP:0008775) | 2.74831015 |
25 | Purpura (HP:0000979) | 2.72283346 |
26 | Microretrognathia (HP:0000308) | 2.70676230 |
27 | Abnormality of the renal cortex (HP:0011035) | 2.70422306 |
28 | Abnormality of the nasal septum (HP:0000419) | 2.66038723 |
29 | Male pseudohermaphroditism (HP:0000037) | 2.65865782 |
30 | Severe visual impairment (HP:0001141) | 2.64412001 |
31 | Type II lissencephaly (HP:0007260) | 2.62261087 |
32 | Cystic liver disease (HP:0006706) | 2.60594673 |
33 | Sparse eyelashes (HP:0000653) | 2.60392587 |
34 | Tubular atrophy (HP:0000092) | 2.48468451 |
35 | Epistaxis (HP:0000421) | 2.45696368 |
36 | Optic nerve hypoplasia (HP:0000609) | 2.41406647 |
37 | Dysdiadochokinesis (HP:0002075) | 2.40093239 |
38 | Depressed nasal tip (HP:0000437) | 2.38831262 |
39 | Abnormality of the labia minora (HP:0012880) | 2.38445975 |
40 | Lissencephaly (HP:0001339) | 2.37935533 |
41 | Febrile seizures (HP:0002373) | 2.37777349 |
42 | Hypomagnesemia (HP:0002917) | 2.37672325 |
43 | Ectropion (HP:0000656) | 2.37182794 |
44 | Nephronophthisis (HP:0000090) | 2.31864761 |
45 | Hypoplasia of the pons (HP:0012110) | 2.28213961 |
46 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.27874741 |
47 | Abnormality of male internal genitalia (HP:0000022) | 2.27160487 |
48 | Abolished electroretinogram (ERG) (HP:0000550) | 2.23131438 |
49 | Pendular nystagmus (HP:0012043) | 2.21875110 |
50 | Renal cortical cysts (HP:0000803) | 2.21192061 |
51 | 11 pairs of ribs (HP:0000878) | 2.20340926 |
52 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.20136329 |
53 | Abnormality of dental color (HP:0011073) | 2.17118887 |
54 | Nausea (HP:0002018) | 2.15788570 |
55 | Back pain (HP:0003418) | 2.15163959 |
56 | Keratoconus (HP:0000563) | 2.14877846 |
57 | Increased corneal curvature (HP:0100692) | 2.14877846 |
58 | Impaired platelet aggregation (HP:0003540) | 2.14261773 |
59 | Abnormal platelet function (HP:0011869) | 2.14261773 |
60 | Abnormality of lateral ventricle (HP:0030047) | 2.14013204 |
61 | Concave nail (HP:0001598) | 2.13787795 |
62 | Hypoplastic labia majora (HP:0000059) | 2.13504212 |
63 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.12443108 |
64 | Abnormality of the renal medulla (HP:0100957) | 2.09696323 |
65 | Abnormality of macular pigmentation (HP:0008002) | 2.09688182 |
66 | Median cleft lip (HP:0000161) | 2.08574101 |
67 | Respiratory distress (HP:0002098) | 2.06526896 |
68 | Decreased central vision (HP:0007663) | 2.05408490 |
69 | Chronic hepatic failure (HP:0100626) | 2.05052499 |
70 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.04038583 |
71 | Alveolar cell carcinoma (HP:0006519) | 2.03539363 |
72 | Chorioretinal atrophy (HP:0000533) | 2.03269452 |
73 | Arthropathy (HP:0003040) | 2.01909711 |
74 | Azoospermia (HP:0000027) | 2.01155990 |
75 | Pachygyria (HP:0001302) | 2.00444243 |
76 | Cerebellar dysplasia (HP:0007033) | 1.98690294 |
77 | Anophthalmia (HP:0000528) | 1.96926032 |
78 | Woolly hair (HP:0002224) | 1.95966688 |
79 | Rib fusion (HP:0000902) | 1.94625986 |
80 | Rhinitis (HP:0012384) | 1.94411839 |
81 | Hypoplastic iliac wings (HP:0002866) | 1.93908838 |
82 | Polydipsia (HP:0001959) | 1.90985390 |
83 | Abnormal drinking behavior (HP:0030082) | 1.90985390 |
84 | Atonic seizures (HP:0010819) | 1.88495644 |
85 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.88456082 |
86 | Glossoptosis (HP:0000162) | 1.88415457 |
87 | Abnormality of the labia majora (HP:0012881) | 1.86549530 |
88 | Inability to walk (HP:0002540) | 1.85264540 |
89 | Acute encephalopathy (HP:0006846) | 1.83298408 |
90 | Absent/shortened dynein arms (HP:0200106) | 1.83173971 |
91 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.83173971 |
92 | Lip pit (HP:0100267) | 1.82912182 |
93 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.82795404 |
94 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.81964363 |
95 | Joint hemorrhage (HP:0005261) | 1.81860756 |
96 | Hyperglycinuria (HP:0003108) | 1.81719091 |
97 | Polyuria (HP:0000103) | 1.81217508 |
98 | Duplicated collecting system (HP:0000081) | 1.80187103 |
99 | Hyperglycinemia (HP:0002154) | 1.79850031 |
100 | Occipital encephalocele (HP:0002085) | 1.79723639 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MST4 | 6.56373065 |
2 | EPHA2 | 5.46486901 |
3 | BRSK2 | 5.39017089 |
4 | WEE1 | 4.06117936 |
5 | GRK1 | 3.97424211 |
6 | STK38L | 2.73631093 |
7 | TRIM28 | 2.50761707 |
8 | CASK | 1.96956363 |
9 | PIK3CG | 1.95832422 |
10 | ADRBK2 | 1.91039499 |
11 | BRSK1 | 1.85379505 |
12 | DYRK3 | 1.75894750 |
13 | BCR | 1.66057067 |
14 | MYLK | 1.57424393 |
15 | MAP3K12 | 1.57011853 |
16 | IKBKB | 1.45031070 |
17 | MKNK2 | 1.44961452 |
18 | STK3 | 1.41787931 |
19 | TAOK3 | 1.33341378 |
20 | SIK3 | 1.29761443 |
21 | PAK3 | 1.26901683 |
22 | PTK2B | 1.25986114 |
23 | NUAK1 | 1.25032785 |
24 | LATS1 | 1.24587173 |
25 | TNK2 | 1.17257844 |
26 | TEC | 1.12261418 |
27 | ZAK | 1.09004859 |
28 | TNIK | 1.07647455 |
29 | WNK3 | 1.07038971 |
30 | MAP3K4 | 1.06766431 |
31 | FRK | 1.05936450 |
32 | WNK4 | 1.05782434 |
33 | TAOK1 | 1.04127722 |
34 | STK39 | 1.03668034 |
35 | MUSK | 0.99456982 |
36 | FER | 0.96172974 |
37 | PNCK | 0.91846798 |
38 | MAP3K3 | 0.85283640 |
39 | CAMK1D | 0.84556536 |
40 | STK38 | 0.82952928 |
41 | BMX | 0.77445269 |
42 | CAMK1G | 0.74856489 |
43 | TLK1 | 0.73302395 |
44 | AKT3 | 0.72013925 |
45 | PRKCI | 0.70129513 |
46 | BMPR2 | 0.68927849 |
47 | PRKCG | 0.65663234 |
48 | BTK | 0.64075687 |
49 | MAP4K2 | 0.60166227 |
50 | MAPK13 | 0.58362098 |
51 | IRAK1 | 0.57988867 |
52 | SGK2 | 0.56399560 |
53 | MAP2K1 | 0.56207630 |
54 | ADRBK1 | 0.56124887 |
55 | LRRK2 | 0.55248712 |
56 | ABL2 | 0.54880707 |
57 | TSSK6 | 0.53081843 |
58 | GRK5 | 0.52056612 |
59 | BCKDK | 0.51290041 |
60 | PIM2 | 0.50501005 |
61 | PRKCE | 0.49616507 |
62 | MKNK1 | 0.48851609 |
63 | DYRK1A | 0.47416521 |
64 | BMPR1B | 0.45625746 |
65 | MINK1 | 0.43771387 |
66 | ILK | 0.41701554 |
67 | ROCK1 | 0.41044196 |
68 | CHUK | 0.40434168 |
69 | ERBB2 | 0.39613361 |
70 | OXSR1 | 0.39116723 |
71 | PIK3CA | 0.38510975 |
72 | DYRK2 | 0.36364740 |
73 | CSNK1A1 | 0.33204065 |
74 | IGF1R | 0.32780925 |
75 | CSF1R | 0.30132241 |
76 | PRKCA | 0.28450113 |
77 | EGFR | 0.28391159 |
78 | MET | 0.28001681 |
79 | PAK1 | 0.27582980 |
80 | CSNK1D | 0.24710496 |
81 | CSNK1E | 0.24521830 |
82 | AKT1 | 0.24512869 |
83 | PLK2 | 0.23535524 |
84 | MAPK15 | 0.23126706 |
85 | SGK3 | 0.22422422 |
86 | PRKACA | 0.21422102 |
87 | MAPKAPK3 | 0.21386018 |
88 | PRKCQ | 0.21173244 |
89 | MATK | 0.19425667 |
90 | ITK | 0.19304920 |
91 | PRKAA2 | 0.18894666 |
92 | MARK3 | 0.18394381 |
93 | EIF2AK1 | 0.17573948 |
94 | PRKACG | 0.17411790 |
95 | SGK223 | 0.17284694 |
96 | SGK494 | 0.17284694 |
97 | ACVR1B | 0.16542087 |
98 | ABL1 | 0.16244667 |
99 | EPHB2 | 0.15935679 |
100 | CSNK2A1 | 0.15809987 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.58347482 |
2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.46713616 |
3 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 3.08440984 |
4 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.66916924 |
5 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 2.48796628 |
6 | Phototransduction_Homo sapiens_hsa04744 | 2.48413629 |
7 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 2.45487735 |
8 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 2.44056685 |
9 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.32443403 |
10 | Circadian rhythm_Homo sapiens_hsa04710 | 1.96213116 |
11 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.95627184 |
12 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.75385674 |
13 | Mineral absorption_Homo sapiens_hsa04978 | 1.74455405 |
14 | Platelet activation_Homo sapiens_hsa04611 | 1.74209523 |
15 | Protein export_Homo sapiens_hsa03060 | 1.69119059 |
16 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.68363397 |
17 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.66082296 |
18 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.61282719 |
19 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.59194251 |
20 | Olfactory transduction_Homo sapiens_hsa04740 | 1.56235695 |
21 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.53820657 |
22 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.49811061 |
23 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.42921792 |
24 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.42251254 |
25 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.38407577 |
26 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.36470477 |
27 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.34727628 |
28 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.34687176 |
29 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.22203654 |
30 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.15259642 |
31 | Sulfur relay system_Homo sapiens_hsa04122 | 1.12510965 |
32 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.10349436 |
33 | Histidine metabolism_Homo sapiens_hsa00340 | 1.09337281 |
34 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.08190633 |
35 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.07963892 |
36 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.04302032 |
37 | ABC transporters_Homo sapiens_hsa02010 | 1.04238999 |
38 | Retinol metabolism_Homo sapiens_hsa00830 | 1.00204200 |
39 | Salivary secretion_Homo sapiens_hsa04970 | 1.00012607 |
40 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.99802532 |
41 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.99069833 |
42 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.96349994 |
43 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.95818011 |
44 | Cocaine addiction_Homo sapiens_hsa05030 | 0.95151086 |
45 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.94746043 |
46 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.93942980 |
47 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.93550732 |
48 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.92673102 |
49 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.92041906 |
50 | Homologous recombination_Homo sapiens_hsa03440 | 0.91683612 |
51 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.89064032 |
52 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.88027943 |
53 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.87782629 |
54 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.86101615 |
55 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.80357500 |
56 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.73879867 |
57 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.70618205 |
58 | Taste transduction_Homo sapiens_hsa04742 | 0.68084124 |
59 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.65066530 |
60 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.63132104 |
61 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.62882241 |
62 | Basal transcription factors_Homo sapiens_hsa03022 | 0.61592753 |
63 | Morphine addiction_Homo sapiens_hsa05032 | 0.60570482 |
64 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.60405277 |
65 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.60105337 |
66 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.59185386 |
67 | Circadian entrainment_Homo sapiens_hsa04713 | 0.59029091 |
68 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.58014848 |
69 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.57665626 |
70 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.56297507 |
71 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.56186530 |
72 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.54259000 |
73 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.52327928 |
74 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.50606055 |
75 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.48646475 |
76 | Purine metabolism_Homo sapiens_hsa00230 | 0.47719550 |
77 | Tight junction_Homo sapiens_hsa04530 | 0.45580130 |
78 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.45291385 |
79 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.43916454 |
80 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.43619420 |
81 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.41999294 |
82 | Mismatch repair_Homo sapiens_hsa03430 | 0.41871367 |
83 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.41733619 |
84 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.40375316 |
85 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.39916912 |
86 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.38233185 |
87 | Parkinsons disease_Homo sapiens_hsa05012 | 0.37402468 |
88 | Prostate cancer_Homo sapiens_hsa05215 | 0.37113383 |
89 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.36911952 |
90 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.36451905 |
91 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.35550049 |
92 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.33534344 |
93 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.33087251 |
94 | RNA polymerase_Homo sapiens_hsa03020 | 0.32300245 |
95 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.32144326 |
96 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.32123880 |
97 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.31151572 |
98 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.30775438 |
99 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.29960793 |
100 | Hepatitis C_Homo sapiens_hsa05160 | 0.29104520 |