ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sensory perception of chemical stimulus (GO:0007606)	9.74095956
2	cellular glucuronidation (GO:0052695)	7.45629530
3	copper ion homeostasis (GO:0055070)	7.44670034
4	glucuronate metabolic process (GO:0019585)	7.05035226
5	uronic acid metabolic process (GO:0006063)	7.05035226
6	ethanol oxidation (GO:0006069)	6.81528127
7	one-carbon compound transport (GO:0019755)	6.79267925
8	regulation of somitogenesis (GO:0014807)	6.72299584
9	copper ion transport (GO:0006825)	6.60581203
10	response to nitrosative stress (GO:0051409)	6.19338364
11	intestinal epithelial cell development (GO:0060576)	4.72618767
12	ethanol metabolic process (GO:0006067)	4.68684538
13	renal absorption (GO:0070293)	4.66904793
14	protein localization to cilium (GO:0061512)	4.66293148
15	excretion (GO:0007588)	4.49194701
16	positive regulation of digestive system process (GO:0060456)	4.39209726
17	primary alcohol catabolic process (GO:0034310)	4.31824585
18	negative regulation of JUN kinase activity (GO:0043508)	4.25024855
19	regulation of cardioblast proliferation (GO:0003264)	4.16518440
20	regulation of secondary heart field cardioblast proliferation (GO:0003266)	4.16518440
21	multicellular organismal water homeostasis (GO:0050891)	4.13999935
22	forebrain neuron development (GO:0021884)	3.90786889
23	tyrosine metabolic process (GO:0006570)	3.84899394
24	serotonin metabolic process (GO:0042428)	3.76815116
25	flavonoid metabolic process (GO:0009812)	3.74203866
26	sodium ion homeostasis (GO:0055078)	3.74115975
27	positive regulation of embryonic development (GO:0040019)	3.59235065
28	transepithelial transport (GO:0070633)	3.51613301
29	pharyngeal system development (GO:0060037)	3.50281635
30	response to copper ion (GO:0046688)	3.41040558
31	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.35620056
32	response to caffeine (GO:0031000)	3.30870795
33	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.27907469
34	iron ion import (GO:0097286)	3.24184957
35	norepinephrine metabolic process (GO:0042415)	3.23667316
36	primary amino compound metabolic process (GO:1901160)	3.22644440
37	sensory perception of taste (GO:0050909)	3.21513283
38	regulation of oxidative phosphorylation (GO:0002082)	3.19217941
39	water homeostasis (GO:0030104)	3.18089949
40	aldehyde catabolic process (GO:0046185)	3.17060203
41	water transport (GO:0006833)	3.15659213
42	central nervous system neuron development (GO:0021954)	3.05410584
43	L-ascorbic acid metabolic process (GO:0019852)	3.01870813
44	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.01802411
45	gas transport (GO:0015669)	3.01728639
46	regulation of cholesterol biosynthetic process (GO:0045540)	2.97910418
47	androgen biosynthetic process (GO:0006702)	2.96426296
48	hormone catabolic process (GO:0042447)	2.93482048
49	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.93437957
50	regulation of metalloenzyme activity (GO:0048552)	2.89479086
51	cellular potassium ion homeostasis (GO:0030007)	2.86560792
52	cellular zinc ion homeostasis (GO:0006882)	2.81210658
53	embryonic skeletal system development (GO:0048706)	2.74793138
54	cerebellar Purkinje cell differentiation (GO:0021702)	2.70275726
55	nucleotide transmembrane transport (GO:1901679)	2.70216187
56	interleukin-6-mediated signaling pathway (GO:0070102)	2.69553432
57	L-serine transport (GO:0015825)	2.67665934
58	fluid transport (GO:0042044)	2.67356846
59	tryptophan metabolic process (GO:0006568)	2.63453043
60	branching involved in salivary gland morphogenesis (GO:0060445)	2.63338335
61	catechol-containing compound biosynthetic process (GO:0009713)	2.61885832
62	catecholamine biosynthetic process (GO:0042423)	2.61885832
63	negative regulation of chondrocyte differentiation (GO:0032331)	2.61023111
64	removal of superoxide radicals (GO:0019430)	2.59871204
65	cellular response to superoxide (GO:0071451)	2.59871204
66	cellular response to oxygen radical (GO:0071450)	2.59871204
67	epoxygenase P450 pathway (GO:0019373)	2.59344923
68	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.58066754
69	positive regulation of steroid biosynthetic process (GO:0010893)	2.55159307
70	middle ear morphogenesis (GO:0042474)	2.53112484
71	positive regulation of neurological system process (GO:0031646)	2.51840628
72	lateral ventricle development (GO:0021670)	2.50614573
73	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.49954645
74	polyol transport (GO:0015791)	2.49912871
75	bicarbonate transport (GO:0015701)	2.49325019
76	sequestering of metal ion (GO:0051238)	2.47330014
77	secretory granule organization (GO:0033363)	2.46958293
78	negative regulation of glycogen biosynthetic process (GO:0045719)	2.42572320
79	regulation of steroid hormone biosynthetic process (GO:0090030)	2.42285522
80	relaxation of cardiac muscle (GO:0055119)	2.41066053
81	extracellular matrix assembly (GO:0085029)	2.39530123
82	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.38485677
83	negative regulation of lipase activity (GO:0060192)	2.37347428
84	positive regulation of hormone biosynthetic process (GO:0046886)	2.36762639
85	regulation of heart rate by cardiac conduction (GO:0086091)	2.35770560
86	regulation of cell fate specification (GO:0042659)	2.34635922
87	regulation of chromatin binding (GO:0035561)	2.32322490
88	adenosine metabolic process (GO:0046085)	2.32075128
89	regulation of female gonad development (GO:2000194)	2.31721506
90	gland morphogenesis (GO:0022612)	2.31213490
91	omega-hydroxylase P450 pathway (GO:0097267)	2.30720242
92	antibacterial humoral response (GO:0019731)	2.29827498
93	O-glycan processing (GO:0016266)	2.28233210
94	phenylpropanoid metabolic process (GO:0009698)	2.27470606
95	regulation of transmission of nerve impulse (GO:0051969)	2.27158431
96	activation of protein kinase A activity (GO:0034199)	2.26818778
97	outer ear morphogenesis (GO:0042473)	2.26751954
98	sensory perception of smell (GO:0007608)	15.7219292
99	chemosensory behavior (GO:0007635)	10.5107732
100	cellular copper ion homeostasis (GO:0006878)	10.0425901

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	4.83546202
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.20221927
3	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.53807738
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.69393433
5	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.21787218
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.17695760
7	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.15453869
8	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.10666570
9	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.10666570
10	DROSHA_22980978_ChIP-Seq_HELA_Human	2.06178753
11	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.02345293
12	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.01205357
13	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.93801953
14	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.87092584
15	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.84105390
16	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.80807211
17	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.77355699
18	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.71455319
19	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.67149427
20	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.66551155
21	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.62665853
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.61391350
23	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.60245362
24	TP53_18474530_ChIP-ChIP_U2OS_Human	1.56386770
25	AHR_22903824_ChIP-Seq_MCF-7_Human	1.52584272
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.50861365
27	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.48399312
28	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.48184955
29	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.48151167
30	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.45878111
31	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.44852933
32	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.44308913
33	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.42074476
34	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.39629478
35	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.39583907
36	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.37591293
37	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.36160866
38	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.34845516
39	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.32890275
40	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32196642
41	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.24559976
42	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.23616181
43	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.22115530
44	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.21658758
45	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.20159821
46	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.20128410
47	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19472875
48	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17921300
49	KDM2B_26808549_Chip-Seq_K562_Human	1.16459638
50	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.15624392
51	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.15148650
52	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.10395896
53	KLF5_25053715_ChIP-Seq_YYC3_Human	1.09491669
54	TP53_16413492_ChIP-PET_HCT116_Human	1.09403523
55	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.09038998
56	GBX2_23144817_ChIP-Seq_PC3_Human	1.05229884
57	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.03993663
58	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.03281237
59	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.03204766
60	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.02807447
61	* FOXO3_23340844_ChIP-Seq_DLD1_Human	1.02060584
62	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.01885400
63	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.00747849
64	CLOCK_20551151_ChIP-Seq_293T_Human	1.00246759
65	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.99858679
66	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.99454920
67	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.98776995
68	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.98638713
69	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.98600487
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.97882314
71	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.97555061
72	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.97500247
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96749747
74	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.96548027
75	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.96428142
76	EGR1_19032775_ChIP-ChIP_M12_Human	0.96420935
77	SOX2_20726797_ChIP-Seq_SW620_Human	0.94864450
78	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.93791724
79	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.93641437
80	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.92828912
81	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.92747442
82	EZH2_22144423_ChIP-Seq_EOC_Human	0.91110434
83	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.90984461
84	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.90193201
85	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.89181209
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.89161347
87	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.88955335
88	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.88514983
89	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.88153561
90	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.88068183
91	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.85449452
92	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.85198742
93	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.80961246
94	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.79516575
95	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.79058876
96	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.78551230
97	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.77088557
98	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.76095120
99	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.75417522
100	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.74186918

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001984_abnormal_olfaction	8.32596316
2	MP0005499_abnormal_olfactory_system	6.07883922
3	MP0005394_taste/olfaction_phenotype	6.07883922
4	MP0008789_abnormal_olfactory_epithelium	5.21081931
5	MP0008875_abnormal_xenobiotic_pharmacok	4.21788388
6	MP0010030_abnormal_orbit_morphology	4.14844618
7	MP0005171_absent_coat_pigmentation	3.14313031
8	MP0001346_abnormal_lacrimal_gland	2.99910690
9	MP0003283_abnormal_digestive_organ	2.96287469
10	MP0002877_abnormal_melanocyte_morpholog	2.65677030
11	MP0000372_irregular_coat_pigmentation	2.08771769
12	MP0005408_hypopigmentation	1.91519937
13	MP0008438_abnormal_cutaneous_collagen	1.88400597
14	MP0002277_abnormal_respiratory_mucosa	1.86030332
15	MP0002163_abnormal_gland_morphology	1.85875681
16	MP0002233_abnormal_nose_morphology	1.84801273
17	MP0000762_abnormal_tongue_morphology	1.80447324
18	MP0001177_atelectasis	1.80052257
19	MP0000613_abnormal_salivary_gland	1.76572473
20	MP0003806_abnormal_nucleotide_metabolis	1.75960300
21	MP0002098_abnormal_vibrissa_morphology	1.75942413
22	MP0003279_aneurysm	1.75179634
23	MP0002132_abnormal_respiratory_system	1.67288526
24	MP0003300_gastrointestinal_ulcer	1.63649509
25	MP0010234_abnormal_vibrissa_follicle	1.63137956
26	MP0004134_abnormal_chest_morphology	1.62464736
27	MP0002254_reproductive_system_inflammat	1.51437080
28	MP0005275_abnormal_skin_tensile	1.48550120
29	MP0005503_abnormal_tendon_morphology	1.42714590
30	MP0001756_abnormal_urination	1.39458328
31	MP0005379_endocrine/exocrine_gland_phen	1.35094107
32	MP0003186_abnormal_redox_activity	1.28670819
33	MP0001485_abnormal_pinna_reflex	1.25656881
34	MP0005388_respiratory_system_phenotype	1.19538820
35	MP0002133_abnormal_respiratory_system	1.19538820
36	MP0003690_abnormal_glial_cell	1.19499855
37	MP0000371_diluted_coat_color	1.10796110
38	MP0000462_abnormal_digestive_system	1.10452010
39	MP0006292_abnormal_olfactory_placode	1.07557461
40	MP0002168_other_aberrant_phenotype	1.07520973
41	MP0000049_abnormal_middle_ear	1.06808215
42	MP0003329_amyloid_beta_deposits	1.01607864
43	MP0003566_abnormal_cell_adhesion	1.01045744
44	MP0008872_abnormal_physiological_respon	1.01014853
45	MP0002332_abnormal_exercise_endurance	0.94226851
46	MP0005508_abnormal_skeleton_morphology	0.93747601
47	MP0002060_abnormal_skin_morphology	0.93136642
48	MP0001270_distended_abdomen	0.92405730
49	MP0002295_abnormal_pulmonary_circulatio	0.92394238
50	MP0000733_abnormal_muscle_development	0.90025199
51	MP0002653_abnormal_ependyma_morphology	0.89705313
52	MP0000534_abnormal_ureter_morphology	0.87371164
53	MP0005248_abnormal_Harderian_gland	0.86679021
54	MP0005646_abnormal_pituitary_gland	0.86561625
55	MP0009697_abnormal_copulation	0.85273314
56	MP0002234_abnormal_pharynx_morphology	0.80963538
57	MP0005257_abnormal_intraocular_pressure	0.80213535
58	MP0001299_abnormal_eye_distance/	0.76128390
59	MP0010678_abnormal_skin_adnexa	0.72808127
60	MP0000678_abnormal_parathyroid_gland	0.71159057
61	MP0003890_abnormal_embryonic-extraembry	0.68422554
62	MP0001905_abnormal_dopamine_level	0.67697436
63	MP0005395_other_phenotype	0.67445986
64	MP0002249_abnormal_larynx_morphology	0.67218164
65	MP0000163_abnormal_cartilage_morphology	0.66843576
66	MP0001186_pigmentation_phenotype	0.65935146
67	MP0005377_hearing/vestibular/ear_phenot	0.65865541
68	MP0003878_abnormal_ear_physiology	0.65865541
69	MP0002751_abnormal_autonomic_nervous	0.65661086
70	MP0010352_gastrointestinal_tract_polyps	0.65546744
71	MP0001501_abnormal_sleep_pattern	0.64631404
72	MP0004742_abnormal_vestibular_system	0.63859112
73	MP0005266_abnormal_metabolism	0.63419685
74	MP0000631_abnormal_neuroendocrine_gland	0.62845959
75	MP0005365_abnormal_bile_salt	0.62315867
76	MP0004782_abnormal_surfactant_physiolog	0.62115163
77	MP0005187_abnormal_penis_morphology	0.61438032
78	MP0010368_abnormal_lymphatic_system	0.61304670
79	MP0000604_amyloidosis	0.59876234
80	MP0000537_abnormal_urethra_morphology	0.58381216
81	MP0009250_abnormal_appendicular_skeleto	0.56247549
82	MP0004272_abnormal_basement_membrane	0.55612784
83	MP0002075_abnormal_coat/hair_pigmentati	0.52516245
84	MP0000383_abnormal_hair_follicle	0.51984304
85	MP0000647_abnormal_sebaceous_gland	0.51689833
86	MP0000566_synostosis	0.51464675
87	MP0002111_abnormal_tail_morphology	0.49955068
88	MP0002116_abnormal_craniofacial_bone	0.49346683
89	MP0000778_abnormal_nervous_system	0.46174581
90	MP0002184_abnormal_innervation	0.46119259
91	MP0002896_abnormal_bone_mineralization	0.45717235
92	MP0000343_altered_response_to	0.42717815
93	MP0005636_abnormal_mineral_homeostasis	0.42495522
94	MP0004019_abnormal_vitamin_homeostasis	0.41462080
95	MP0001963_abnormal_hearing_physiology	0.41148766
96	MP0003633_abnormal_nervous_system	0.40984442
97	MP0004264_abnormal_extraembryonic_tissu	0.39198702
98	MP0003938_abnormal_ear_development	0.39165302
99	MP0005623_abnormal_meninges_morphology	0.39134290
100	MP0005584_abnormal_enzyme/coenzyme_acti	0.39043397

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypokalemic alkalosis (HP:0001949)	9.00627268
2	Hyperactive renin-angiotensin system (HP:0000841)	8.61594257
3	Decreased circulating renin level (HP:0003351)	8.21851747
4	Hyperaldosteronism (HP:0000859)	7.84878244
5	Renal salt wasting (HP:0000127)	7.02241000
6	Chronic bronchitis (HP:0004469)	6.70398869
7	Abnormality of chloride homeostasis (HP:0011422)	6.33524975
8	Abnormality of sodium homeostasis (HP:0010931)	5.46465753
9	Hyperkalemia (HP:0002153)	5.26412218
10	Hyponatremia (HP:0002902)	5.21484978
11	Alkalosis (HP:0001948)	4.92260427
12	Conjugated hyperbilirubinemia (HP:0002908)	4.91045439
13	Metabolic alkalosis (HP:0200114)	4.81458993
14	Abnormality of the right ventricle (HP:0001707)	4.71934748
15	Abnormality of renin-angiotensin system (HP:0000847)	4.62000614
16	Hypokalemia (HP:0002900)	4.61715616
17	Urethral obstruction (HP:0000796)	4.34751238
18	Arterial tortuosity (HP:0005116)	3.80019633
19	Hypothermia (HP:0002045)	3.74876609
20	Abnormality of potassium homeostasis (HP:0011042)	3.61807472
21	Adrenal overactivity (HP:0002717)	3.58486634
22	Hydroureter (HP:0000072)	3.53846405
23	Ileus (HP:0002595)	3.49703820
24	Abnormality of cochlea (HP:0000375)	3.32419864
25	Vascular tortuosity (HP:0004948)	3.31396017
26	Spontaneous hematomas (HP:0007420)	3.22943480
27	Lip pit (HP:0100267)	3.08604129
28	Osteomalacia (HP:0002749)	2.96539142
29	Broad ribs (HP:0000885)	2.96417400
30	Spinal muscular atrophy (HP:0007269)	2.75571907
31	Hypotension (HP:0002615)	2.75151532
32	Vascular calcification (HP:0004934)	2.65989597
33	Aplasia involving bones of the upper limbs (HP:0009823)	2.65876155
34	Aplasia of the phalanges of the hand (HP:0009802)	2.65876155
35	Aplasia involving bones of the extremities (HP:0009825)	2.65876155
36	Rectal prolapse (HP:0002035)	2.62971320
37	Abnormal tarsal ossification (HP:0008369)	2.62320808
38	Tarsal synostosis (HP:0008368)	2.57956752
39	Bronchiectasis (HP:0002110)	2.57171350
40	Vaginal fistula (HP:0004320)	2.53676508
41	Woolly hair (HP:0002224)	2.50783765
42	Male infertility (HP:0003251)	2.48150826
43	Bifid scrotum (HP:0000048)	2.44902912
44	Cardiovascular calcification (HP:0011915)	2.40830354
45	Synostosis involving the elbow (HP:0003938)	2.39531244
46	Humeroradial synostosis (HP:0003041)	2.39531244
47	Synostosis involving bones of the feet (HP:0009140)	2.38678478
48	Synostosis involving bones of the lower limbs (HP:0009138)	2.38678478
49	Renal tubular dysfunction (HP:0000124)	2.36498506
50	Morphological abnormality of the inner ear (HP:0011390)	2.25297846
51	Esophageal varix (HP:0002040)	2.15906607
52	Bronchitis (HP:0012387)	2.14257106
53	Down-sloping shoulders (HP:0200021)	2.14116063
54	Hypercalciuria (HP:0002150)	2.10668730
55	Renal tubular acidosis (HP:0001947)	2.07603050
56	Flat acetabular roof (HP:0003180)	2.04308914
57	Dehydration (HP:0001944)	2.03942308
58	Polyuria (HP:0000103)	2.03876466
59	Wormian bones (HP:0002645)	2.01597633
60	Hyperphosphaturia (HP:0003109)	2.00129774
61	Ureteral obstruction (HP:0006000)	2.00013007
62	Hip dysplasia (HP:0001385)	1.99129471
63	Distal lower limb muscle weakness (HP:0009053)	1.97669923
64	Exostoses (HP:0100777)	1.97541227
65	Nasolacrimal duct obstruction (HP:0000579)	1.94896914
66	Upper limb muscle weakness (HP:0003484)	1.90946389
67	Abnormality of Sharpey fibers (HP:0100685)	1.90705644
68	Bladder carcinoma (HP:0002862)	1.88432167
69	Bladder neoplasm (HP:0009725)	1.88432167
70	Bladder diverticulum (HP:0000015)	1.85448271
71	Ulnar bowing (HP:0003031)	1.85257651
72	Abnormal urine output (HP:0012590)	1.83653433
73	Stomach cancer (HP:0012126)	1.82673942
74	Chondrocalcinosis (HP:0000934)	1.79112368
75	Abnormality of renal excretion (HP:0011036)	1.78367818
76	Lower limb amyotrophy (HP:0007210)	1.78171980
77	Abnormal urine phosphate concentration (HP:0012599)	1.77942638
78	Abnormal foot bone ossification (HP:0010675)	1.76263430
79	Redundant skin (HP:0001582)	1.74028849
80	Male pseudohermaphroditism (HP:0000037)	1.73251071
81	Right ventricular cardiomyopathy (HP:0011663)	1.72887789
82	Mask-like facies (HP:0000298)	1.72178897
83	Septo-optic dysplasia (HP:0100842)	1.68069406
84	Hepatitis (HP:0012115)	1.66662311
85	Synostosis involving bones of the hand (HP:0004278)	1.66651353
86	Abnormal atrioventricular conduction (HP:0005150)	1.63685527
87	Abnormal ciliary motility (HP:0012262)	1.62829116
88	Premature rupture of membranes (HP:0001788)	1.62192647
89	Abnormality of the nasolacrimal system (HP:0000614)	1.61176957
90	Stenosis of the external auditory canal (HP:0000402)	1.60655000
91	Metabolic acidosis (HP:0001942)	1.56701533
92	Carpal synostosis (HP:0009702)	1.55198430
93	Abnormality of the humerus (HP:0003063)	1.54994064
94	Distal lower limb amyotrophy (HP:0008944)	1.54482384
95	Chronic diarrhea (HP:0002028)	1.53836821
96	Labial hypoplasia (HP:0000066)	1.52645632
97	Sparse scalp hair (HP:0002209)	1.50520527
98	Dysphonia (HP:0001618)	1.50237213
99	Syncope (HP:0001279)	1.50220038
100	Prolonged QT interval (HP:0001657)	1.50147966

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LMTK2	9.94102805
2	MAP3K3	4.07190970
3	FRK	3.69150874
4	MAP2K3	3.10919169
5	PRKG2	2.44261914
6	MAPK15	2.36148872
7	HIPK2	2.13813106
8	TAOK1	2.12823342
9	LATS1	2.00412296
10	RPS6KB2	1.82843112
11	NUAK1	1.67902133
12	RIPK1	1.60163531
13	STK39	1.54231679
14	TAOK2	1.51091268
15	CSNK1A1L	1.49649160
16	ERBB3	1.46948197
17	STK38L	1.35711885
18	MST1R	1.21167828
19	PAK3	1.17157403
20	SCYL2	1.08418031
21	ERN1	1.08170056
22	ZAK	1.07686231
23	EPHB2	1.07674078
24	TTK	1.05708879
25	CAMK2D	1.05359107
26	TGFBR1	1.01258045
27	PBK	1.00839611
28	PDK2	1.00183137
29	MAP3K2	1.00071793
30	CDK6	0.99432718
31	BMPR1B	0.98547211
32	TRPM7	0.95950610
33	CAMK2B	0.95290971
34	LATS2	0.94638478
35	TYRO3	0.82155184
36	MAP2K4	0.74912995
37	FGFR2	0.74441055
38	MAP2K2	0.74233716
39	FER	0.72552589
40	CSNK1G2	0.71169480
41	STK10	0.71058729
42	MAP3K7	0.69590789
43	CSNK1G1	0.69527119
44	MAP2K1	0.69311141
45	ROCK1	0.67658190
46	GRK6	0.66291063
47	DAPK2	0.63198345
48	MST4	0.62914929
49	ALK	0.62256025
50	EPHA2	0.61972193
51	CSNK1G3	0.61962678
52	ERBB2	0.61850206
53	TGFBR2	0.60912182
54	MAP3K9	0.60349718
55	WNK4	0.60217338
56	PTK2	0.59657433
57	MAP2K7	0.58757808
58	MAP3K11	0.57037318
59	ROCK2	0.54882209
60	MELK	0.54766180
61	DDR2	0.54666759
62	TYK2	0.53685895
63	MAP3K4	0.53403263
64	NTRK1	0.53123593
65	SIK2	0.53077152
66	MAPKAPK5	0.52550711
67	CAMK2G	0.49803960
68	CASK	0.49343544
69	ACVR1B	0.48870712
70	EPHA3	0.48509717
71	MAPKAPK3	0.45918235
72	MET	0.44531407
73	ERBB4	0.42947946
74	PRKCE	0.42613194
75	NEK6	0.42183924
76	PAK4	0.41924003
77	EEF2K	0.39071181
78	STK38	0.38581589
79	TNK2	0.34627502
80	CAMK1	0.33016754
81	PDGFRA	0.32505880
82	NLK	0.29949728
83	OXSR1	0.29679774
84	BMX	0.28163717
85	CHEK2	0.27554529
86	MAP3K1	0.27476519
87	ADRBK1	0.26875262
88	SIK1	0.25935037
89	EIF2AK3	0.25349629
90	CAMK2A	0.24710834
91	WNK1	0.24409260
92	EPHB1	0.23285961
93	TTN	0.21840248
94	MAPK1	0.21025931
95	GRK7	0.20919753
96	ABL2	0.20747530
97	PRKCH	0.19700625
98	MAP3K6	0.19138341
99	STK3	0.19005325
100	CDK8	0.18743429

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	4.53351737
2	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.92798483
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.66372358
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.06405035
5	Glutathione metabolism_Homo sapiens_hsa00480	3.03725208
6	ABC transporters_Homo sapiens_hsa02010	2.84820238
7	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.81392817
8	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.71101734
9	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.69087828
10	Chemical carcinogenesis_Homo sapiens_hsa05204	2.40556752
11	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	2.17361461
12	Thyroid hormone synthesis_Homo sapiens_hsa04918	2.14269118
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.10430977
14	Butanoate metabolism_Homo sapiens_hsa00650	2.09340167
15	Retinol metabolism_Homo sapiens_hsa00830	1.95792651
16	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.83988301
17	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.83586034
18	Taste transduction_Homo sapiens_hsa04742	1.79952971
19	Caffeine metabolism_Homo sapiens_hsa00232	1.78825522
20	Bile secretion_Homo sapiens_hsa04976	1.76656463
21	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.75379540
22	Salivary secretion_Homo sapiens_hsa04970	1.54892531
23	beta-Alanine metabolism_Homo sapiens_hsa00410	1.48067989
24	Sulfur metabolism_Homo sapiens_hsa00920	1.47590048
25	Mineral absorption_Homo sapiens_hsa04978	1.47098181
26	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.39535738
27	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.38983829
28	Fatty acid degradation_Homo sapiens_hsa00071	1.35887812
29	Histidine metabolism_Homo sapiens_hsa00340	1.35740453
30	Gastric acid secretion_Homo sapiens_hsa04971	1.30553306
31	Vibrio cholerae infection_Homo sapiens_hsa05110	1.22441365
32	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.18573337
33	Tyrosine metabolism_Homo sapiens_hsa00350	1.10768324
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.04891789
35	Axon guidance_Homo sapiens_hsa04360	1.01299754
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84799016
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.82346143
38	cAMP signaling pathway_Homo sapiens_hsa04024	0.79768932
39	Adherens junction_Homo sapiens_hsa04520	0.79030676
40	Morphine addiction_Homo sapiens_hsa05032	0.79007171
41	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.78852945
42	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.78785859
43	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.75598092
44	Renin secretion_Homo sapiens_hsa04924	0.73670747
45	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.72809091
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68071742
47	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.67157330
48	Insulin secretion_Homo sapiens_hsa04911	0.65780697
49	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65321186
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.64570396
51	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.63537702
52	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.62990826
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.60163054
54	Propanoate metabolism_Homo sapiens_hsa00640	0.59968274
55	Pancreatic secretion_Homo sapiens_hsa04972	0.56569998
56	Circadian entrainment_Homo sapiens_hsa04713	0.55275877
57	Galactose metabolism_Homo sapiens_hsa00052	0.53116949
58	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.47373125
59	Estrogen signaling pathway_Homo sapiens_hsa04915	0.47208867
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46882691
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46680451
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.46216046
63	GnRH signaling pathway_Homo sapiens_hsa04912	0.46189685
64	GABAergic synapse_Homo sapiens_hsa04727	0.45335403
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.42833791
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.39675572
67	Cholinergic synapse_Homo sapiens_hsa04725	0.38719646
68	Melanogenesis_Homo sapiens_hsa04916	0.38176344
69	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.37264640
70	Rap1 signaling pathway_Homo sapiens_hsa04015	0.36973517
71	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.34738726
72	African trypanosomiasis_Homo sapiens_hsa05143	0.33905867
73	Prion diseases_Homo sapiens_hsa05020	0.32165511
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.31841279
75	Gap junction_Homo sapiens_hsa04540	0.31622848
76	Type II diabetes mellitus_Homo sapiens_hsa04930	0.29975991
77	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.29712676
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28494733
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.26777170
80	Graft-versus-host disease_Homo sapiens_hsa05332	0.26763983
81	Dopaminergic synapse_Homo sapiens_hsa04728	0.26538790
82	Tight junction_Homo sapiens_hsa04530	0.26482648
83	Fatty acid elongation_Homo sapiens_hsa00062	0.25961533
84	Proteoglycans in cancer_Homo sapiens_hsa05205	0.23705615
85	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.21517555
86	Notch signaling pathway_Homo sapiens_hsa04330	0.20773071
87	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.20032873
88	Amphetamine addiction_Homo sapiens_hsa05031	0.19704032
89	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.19030863
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.18863886
91	Prostate cancer_Homo sapiens_hsa05215	0.18831532
92	Cocaine addiction_Homo sapiens_hsa05030	0.17387806
93	Phototransduction_Homo sapiens_hsa04744	0.16687005
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.16174106
95	PPAR signaling pathway_Homo sapiens_hsa03320	0.14977052
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.14721186
97	Focal adhesion_Homo sapiens_hsa04510	0.14063932
98	Sulfur relay system_Homo sapiens_hsa04122	0.14005459
99	Melanoma_Homo sapiens_hsa05218	0.13552674
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.12769693

GLYATL3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »