ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pattern specification involved in kidney development (GO:0061004)	8.48908493
2	fatty-acyl-CoA biosynthetic process (GO:0046949)	8.07800035
3	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	7.93562206
4	thioester biosynthetic process (GO:0035384)	7.84337659
5	acyl-CoA biosynthetic process (GO:0071616)	7.84337659
6	alpha-linolenic acid metabolic process (GO:0036109)	7.78779068
7	pyrimidine-containing compound transmembrane transport (GO:0072531)	7.58529877
8	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	7.38146021
9	lactation (GO:0007595)	7.00204021
10	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	6.89205726
11	linoleic acid metabolic process (GO:0043651)	6.67549110
12	regulation of sequestering of triglyceride (GO:0010889)	6.64193834
13	mammary gland epithelial cell differentiation (GO:0060644)	6.27919911
14	positive regulation of p38MAPK cascade (GO:1900745)	6.13516109
15	fatty acid transmembrane transport (GO:1902001)	6.13417928
16	carnitine shuttle (GO:0006853)	6.09644736
17	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	6.06440694
18	ectoderm development (GO:0007398)	5.97392954
19	fatty-acyl-CoA metabolic process (GO:0035337)	5.78650590
20	secretion by tissue (GO:0032941)	5.72149341
21	biotin metabolic process (GO:0006768)	5.71432809
22	nucleoside transmembrane transport (GO:1901642)	5.53875140
23	tooth mineralization (GO:0034505)	5.06266103
24	acetyl-CoA metabolic process (GO:0006084)	5.04380872
25	nucleobase catabolic process (GO:0046113)	4.93194933
26	N-acetylneuraminate metabolic process (GO:0006054)	4.90209070
27	body fluid secretion (GO:0007589)	4.78805283
28	triglyceride biosynthetic process (GO:0019432)	4.69885923
29	embryonic process involved in female pregnancy (GO:0060136)	4.60818984
30	O-glycan processing (GO:0016266)	4.55074697
31	carnitine transmembrane transport (GO:1902603)	4.51815439
32	acylglycerol biosynthetic process (GO:0046463)	4.51667913
33	neutral lipid biosynthetic process (GO:0046460)	4.51667913
34	coenzyme A biosynthetic process (GO:0015937)	4.43538006
35	segment specification (GO:0007379)	4.43390033
36	folic acid transport (GO:0015884)	4.41593615
37	regulation of p38MAPK cascade (GO:1900744)	4.34133875
38	regulation of apoptotic process involved in morphogenesis (GO:1902337)	4.31386449
39	response to phenylpropanoid (GO:0080184)	4.30776676
40	COPI coating of Golgi vesicle (GO:0048205)	4.22079761
41	Golgi transport vesicle coating (GO:0048200)	4.22079761
42	regulation of penile erection (GO:0060405)	4.18630772
43	nucleoside transport (GO:0015858)	4.16424676
44	amino-acid betaine transport (GO:0015838)	4.13433860
45	carnitine transport (GO:0015879)	4.13433860
46	long-chain fatty acid transport (GO:0015909)	4.11464733
47	positive regulation of macrophage cytokine production (GO:0060907)	3.94632418
48	lipid storage (GO:0019915)	3.93790088
49	regulation of triglyceride biosynthetic process (GO:0010866)	3.89096464
50	copper ion transport (GO:0006825)	3.86917658
51	low-density lipoprotein particle clearance (GO:0034383)	3.82922966
52	phagocytosis, recognition (GO:0006910)	3.82057223
53	regulation of triglyceride metabolic process (GO:0090207)	3.80499627
54	fatty acid transport (GO:0015908)	3.70485864
55	positive regulation of triglyceride metabolic process (GO:0090208)	3.66593462
56	growth hormone receptor signaling pathway (GO:0060396)	3.64911196
57	heme transport (GO:0015886)	3.62674204
58	intracellular lipid transport (GO:0032365)	3.62085058
59	oligosaccharide metabolic process (GO:0009311)	3.61766464
60	pentose-phosphate shunt (GO:0006098)	3.58945394
61	acyl-CoA metabolic process (GO:0006637)	3.58298188
62	thioester metabolic process (GO:0035383)	3.58298188
63	zinc ion transport (GO:0006829)	3.55100993
64	positive regulation of lipid storage (GO:0010884)	3.54404366
65	valine metabolic process (GO:0006573)	3.51254475
66	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	3.49798224
67	negative regulation of execution phase of apoptosis (GO:1900118)	3.47697596
68	negative regulation of fatty acid transport (GO:2000192)	3.45904229
69	coenzyme A metabolic process (GO:0015936)	3.39207286
70	regulation of macrophage cytokine production (GO:0010935)	3.37056229
71	regulation of vasculogenesis (GO:2001212)	3.32925973
72	regulation of triglyceride catabolic process (GO:0010896)	3.30131017
73	triglyceride metabolic process (GO:0006641)	3.28398872
74	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.28086076
75	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.28086076
76	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.28086076
77	triglyceride catabolic process (GO:0019433)	3.26597549
78	regulation of endothelial cell differentiation (GO:0045601)	3.26594393
79	transcytosis (GO:0045056)	3.25415747
80	urate metabolic process (GO:0046415)	3.24306511
81	angiogenesis involved in wound healing (GO:0060055)	3.23102902
82	NADPH regeneration (GO:0006740)	3.19446369
83	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.10381124
84	iron coordination entity transport (GO:1901678)	3.09802627
85	acylglycerol metabolic process (GO:0006639)	3.09684410
86	cellular response to growth hormone stimulus (GO:0071378)	3.06917076
87	neutral lipid metabolic process (GO:0006638)	3.05688856
88	sialylation (GO:0097503)	3.04100998
89	acylglycerol catabolic process (GO:0046464)	3.01104497
90	neutral lipid catabolic process (GO:0046461)	3.01104497
91	positive regulation of tissue remodeling (GO:0034105)	2.99695131
92	galactose metabolic process (GO:0006012)	2.97108182
93	positive regulation of histone deacetylation (GO:0031065)	2.95001694
94	positive regulation of triglyceride lipase activity (GO:0061365)	2.92995194
95	positive regulation of lipoprotein lipase activity (GO:0051006)	2.92995194
96	localization within membrane (GO:0051668)	2.92203394
97	cellular carbohydrate biosynthetic process (GO:0034637)	2.91655449
98	quaternary ammonium group transport (GO:0015697)	2.91463979
99	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.91050776
100	oligosaccharide biosynthetic process (GO:0009312)	11.9195594

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	7.35853555
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	6.21561780
3	ESR1_21235772_ChIP-Seq_MCF-7_Human	4.90724942
4	ESR2_21235772_ChIP-Seq_MCF-7_Human	3.95693905
5	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.80074837
6	CLOCK_20551151_ChIP-Seq_293T_Human	3.44702752
7	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.30672783
8	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	3.28958081
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.82141526
10	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.64008307
11	AR_21572438_ChIP-Seq_LNCaP_Human	2.56072385
12	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.55773026
13	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.54725154
14	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.52889610
15	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.52241001
16	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.36333622
17	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.28845566
18	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.09167835
19	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.07997035
20	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.99323015
21	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.96558302
22	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.92961246
23	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.89305711
24	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.82012513
25	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.78098172
26	RXR_22108803_ChIP-Seq_LS180_Human	1.77232622
27	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.76989440
28	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.69824645
29	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.65613217
30	SOX2_20726797_ChIP-Seq_SW620_Human	1.58455152
31	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.53974644
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.52182141
33	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.44298104
34	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.43760465
35	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.40873718
36	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.36790862
37	GATA4_25053715_ChIP-Seq_YYC3_Human	1.33978286
38	RACK7_27058665_Chip-Seq_MCF-7_Human	1.29876297
39	KLF5_25053715_ChIP-Seq_YYC3_Human	1.28735018
40	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.26364119
41	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.26357830
42	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.25312686
43	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.24751963
44	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.18734171
45	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.17242442
46	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.14726139
47	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.14726139
48	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.11589454
49	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.11098170
50	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.10473584
51	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.09414196
52	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.08396470
53	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.08300016
54	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.04783016
55	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.03617017
56	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.02847722
57	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.98197464
58	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.97792693
59	GATA1_19941826_ChIP-Seq_K562_Human	0.96761821
60	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.95218942
61	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.94814899
62	ATF3_27146783_Chip-Seq_COLON_Human	0.91997598
63	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.91456750
64	LXR_22292898_ChIP-Seq_THP-1_Human	0.91070351
65	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.89549258
66	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.89227529
67	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.88500518
68	TP63_23658742_ChIP-Seq_EP156T_Human	0.88239203
69	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.88029292
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.87356557
71	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.86583683
72	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.85870871
73	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.85796575
74	CHD1_26751641_Chip-Seq_LNCaP_Human	0.85730827
75	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.84787856
76	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.83888495
77	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.83404455
78	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.82628001
79	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.82428509
80	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.82000717
81	CREB1_26743006_Chip-Seq_LNCaP_Human	0.80522954
82	GATA2_19941826_ChIP-Seq_K562_Human	0.80319574
83	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.80314367
84	TP53_18474530_ChIP-ChIP_U2OS_Human	0.79991573
85	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.79913125
86	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.79741791
87	CJUN_26792858_Chip-Seq_BT549_Human	0.79200332
88	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.78909593
89	CBP_21632823_ChIP-Seq_H3396_Human	0.77970350
90	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.77887499
91	KDM2B_26808549_Chip-Seq_K562_Human	0.77855005
92	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.77782222
93	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.77334178
94	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.77084844
95	AR_25329375_ChIP-Seq_VCAP_Human	0.76215625
96	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.76086764
97	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.76086539
98	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.75523772
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.75056426
100	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.73749004

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	4.60777443
2	MP0003136_yellow_coat_color	3.59145571
3	MP0000627_abnormal_mammary_gland	3.55601985
4	MP0005083_abnormal_biliary_tract	3.37311194
5	MP0003303_peritoneal_inflammation	3.19830683
6	MP0003300_gastrointestinal_ulcer	3.01347197
7	MP0004130_abnormal_muscle_cell	2.90041645
8	MP0002254_reproductive_system_inflammat	2.84595256
9	MP0001873_stomach_inflammation	2.65387150
10	MP0004147_increased_porphyrin_level	2.54759866
11	MP0003705_abnormal_hypodermis_morpholog	2.49869983
12	MP0004019_abnormal_vitamin_homeostasis	2.41931766
13	MP0003011_delayed_dark_adaptation	2.38993474
14	MP0005360_urolithiasis	2.22698996
15	MP0003718_maternal_effect	2.15890766
16	MP0001881_abnormal_mammary_gland	12.7596376
17	MP0005085_abnormal_gallbladder_physiolo	1.94459577
18	MP0002796_impaired_skin_barrier	1.90788367
19	MP0004264_abnormal_extraembryonic_tissu	1.81185736
20	MP0005666_abnormal_adipose_tissue	1.55559639
21	MP0001666_abnormal_nutrient_absorption	1.45411459
22	MP0005395_other_phenotype	1.43368870
23	MP0002118_abnormal_lipid_homeostasis	1.41350498
24	MP0005670_abnormal_white_adipose	1.38061229
25	MP0008438_abnormal_cutaneous_collagen	1.35685967
26	MP0002139_abnormal_hepatobiliary_system	1.34336954
27	MP0010329_abnormal_lipoprotein_level	1.33811961
28	MP0002098_abnormal_vibrissa_morphology	1.30950561
29	MP0001664_abnormal_digestion	1.30107685
30	MP0004185_abnormal_adipocyte_glucose	1.23725361
31	MP0004272_abnormal_basement_membrane	1.23084421
32	MP0005375_adipose_tissue_phenotype	1.15276570
33	MP0002009_preneoplasia	1.11556727
34	MP0000377_abnormal_hair_follicle	1.04204945
35	MP0005501_abnormal_skin_physiology	0.97635345
36	MP0005584_abnormal_enzyme/coenzyme_acti	0.97115632
37	MP0001663_abnormal_digestive_system	0.93466966
38	MP0010352_gastrointestinal_tract_polyps	0.92008086
39	MP0010678_abnormal_skin_adnexa	0.91692426
40	MP0003566_abnormal_cell_adhesion	0.90012604
41	MP0002971_abnormal_brown_adipose	0.89146239
42	MP0002168_other_aberrant_phenotype	0.89053470
43	MP0005275_abnormal_skin_tensile	0.88906761
44	MP0005332_abnormal_amino_acid	0.88071820
45	MP0003936_abnormal_reproductive_system	0.87449348
46	MP0001849_ear_inflammation	0.87241412
47	MP0009384_cardiac_valve_regurgitation	0.87125508
48	MP0000639_abnormal_adrenal_gland	0.82337881
49	MP0000490_abnormal_crypts_of	0.82021570
50	MP0000609_abnormal_liver_physiology	0.81657153
51	MP0005334_abnormal_fat_pad	0.80692518
52	MP0001958_emphysema	0.80100026
53	MP0002970_abnormal_white_adipose	0.77746039
54	MP0005076_abnormal_cell_differentiation	0.76086180
55	MP0008770_decreased_survivor_rate	0.75847671
56	MP0005636_abnormal_mineral_homeostasis	0.73775141
57	MP0005381_digestive/alimentary_phenotyp	0.73670029
58	MP0000013_abnormal_adipose_tissue	0.73205023
59	MP0003075_altered_response_to	0.70496386
60	MP0002396_abnormal_hematopoietic_system	0.70275822
61	MP0002896_abnormal_bone_mineralization	0.69515534
62	MP0003045_fibrosis	0.69509877
63	MP0003448_altered_tumor_morphology	0.69151007
64	MP0003690_abnormal_glial_cell	0.67237492
65	MP0004947_skin_inflammation	0.64182597
66	MP0009643_abnormal_urine_homeostasis	0.63445996
67	MP0003959_abnormal_lean_body	0.63015760
68	MP0002078_abnormal_glucose_homeostasis	0.61786795
69	MP0009278_abnormal_bone_marrow	0.60915341
70	MP0003656_abnormal_erythrocyte_physiolo	0.59839732
71	MP0005171_absent_coat_pigmentation	0.59635481
72	MP0003950_abnormal_plasma_membrane	0.59284158
73	MP0005023_abnormal_wound_healing	0.58838331
74	MP0000003_abnormal_adipose_tissue	0.58043003
75	MP0005452_abnormal_adipose_tissue	0.57482228
76	MP0001216_abnormal_epidermal_layer	0.55484829
77	MP0002332_abnormal_exercise_endurance	0.54355740
78	MP0001177_atelectasis	0.52767868
79	MP0001765_abnormal_ion_homeostasis	0.51184187
80	MP0002282_abnormal_trachea_morphology	0.50512002
81	MP0002166_altered_tumor_susceptibility	0.50314986
82	MP0005319_abnormal_enzyme/_coenzyme	0.49793674
83	MP0002060_abnormal_skin_morphology	0.49608034
84	MP0005164_abnormal_response_to	0.48276871
85	MP0003453_abnormal_keratinocyte_physiol	0.47311416
86	MP0005165_increased_susceptibility_to	0.45122669
87	MP0006054_spinal_hemorrhage	0.44643440
88	MP0003948_abnormal_gas_homeostasis	0.43985896
89	MP0009931_abnormal_skin_appearance	0.43812017
90	MP0001533_abnormal_skeleton_physiology	0.41126324
91	MP0005408_hypopigmentation	0.40484078
92	MP0010771_integument_phenotype	0.39067571
93	MP0001756_abnormal_urination	0.38831585
94	MP0000427_abnormal_hair_cycle	0.38737658
95	MP0001851_eye_inflammation	0.38264159
96	MP0000750_abnormal_muscle_regeneration	0.37320610
97	MP0002133_abnormal_respiratory_system	0.37173501
98	MP0005388_respiratory_system_phenotype	0.37173501
99	MP0001879_abnormal_lymphatic_vessel	0.36032817
100	MP0005448_abnormal_energy_balance	0.34968312

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of purine metabolism (HP:0004352)	6.28150153
2	Amelogenesis imperfecta (HP:0000705)	5.62937541
3	Gout (HP:0001997)	5.38942185
4	Axonal loss (HP:0003447)	5.28740594
5	Congenital ichthyosiform erythroderma (HP:0007431)	4.90385987
6	Thin bony cortex (HP:0002753)	4.69964874
7	Overgrowth (HP:0001548)	4.22866443
8	Abnormality of calcium-phosphate metabolism (HP:0100530)	3.88743644
9	Abnormality of nucleobase metabolism (HP:0010932)	3.81908767
10	Nephritis (HP:0000123)	3.74047243
11	Stridor (HP:0010307)	3.69301719
12	Pili torti (HP:0003777)	3.64650699
13	Metaphyseal dysplasia (HP:0100255)	3.59320157
14	Tubulointerstitial nephritis (HP:0001970)	3.40750856
15	Protuberant abdomen (HP:0001538)	3.37407701
16	Enlarged epiphyses (HP:0010580)	3.27100149
17	Abnormality of renal excretion (HP:0011036)	3.25363184
18	Right ventricular cardiomyopathy (HP:0011663)	3.22783234
19	Aortic aneurysm (HP:0004942)	3.20445861
20	Neurodegeneration (HP:0002180)	3.19509294
21	Subcapsular cataract (HP:0000523)	3.11678357
22	Abnormality of renal resorption (HP:0011038)	3.06605162
23	Curly hair (HP:0002212)	3.05819960
24	Ectropion (HP:0000656)	3.01484341
25	Tubulointerstitial fibrosis (HP:0005576)	2.96789192
26	Cerebral aneurysm (HP:0004944)	2.93206225
27	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.90892883
28	Bone cyst (HP:0012062)	2.83141389
29	Ketoacidosis (HP:0001993)	2.76932266
30	Glomerulosclerosis (HP:0000096)	2.76076575
31	Turricephaly (HP:0000262)	2.73404756
32	Hyperglycinemia (HP:0002154)	2.71925131
33	Hyperglycinuria (HP:0003108)	2.65531310
34	Aortic dissection (HP:0002647)	2.64033528
35	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.63536359
36	Epiphyseal dysplasia (HP:0002656)	2.52604271
37	Buphthalmos (HP:0000557)	2.52201528
38	Abnormal auditory evoked potentials (HP:0006958)	2.51375039
39	Asymmetry of the thorax (HP:0001555)	2.51183666
40	Hyperuricemia (HP:0002149)	2.47820635
41	Increased purine levels (HP:0004368)	2.47820635
42	Deep venous thrombosis (HP:0002625)	2.44596697
43	Renal salt wasting (HP:0000127)	2.42753287
44	Abnormality of transition element cation homeostasis (HP:0011030)	2.41638886
45	Enlarged penis (HP:0000040)	2.39226787
46	Abdominal distention (HP:0003270)	2.34594999
47	Atrophic scars (HP:0001075)	2.31632242
48	Cortical dysplasia (HP:0002539)	2.24682240
49	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.24262182
50	Osteolytic defects of the hand bones (HP:0009699)	2.24262182
51	Autoamputation (HP:0001218)	2.24067302
52	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.22951373
53	Poor eye contact (HP:0000817)	2.22350864
54	Hypoplasia of the iris (HP:0007676)	2.20375254
55	Nephrolithiasis (HP:0000787)	2.19647897
56	Aneurysm (HP:0002617)	2.17573270
57	Premature skin wrinkling (HP:0100678)	2.17478538
58	Tubular atrophy (HP:0000092)	2.17080848
59	Widely patent fontanelles and sutures (HP:0004492)	2.16728679
60	Wide cranial sutures (HP:0010537)	2.15013522
61	Long toe (HP:0010511)	2.13527084
62	Abnormal hair laboratory examination (HP:0003328)	2.13273696
63	Conjunctival hamartoma (HP:0100780)	2.12920676
64	Ketosis (HP:0001946)	2.11859613
65	Abnormality of glycine metabolism (HP:0010895)	2.08629609
66	Abnormality of serine family amino acid metabolism (HP:0010894)	2.08629609
67	Abnormality of vision evoked potentials (HP:0000649)	2.07630723
68	Abnormality of dental color (HP:0011073)	2.07566496
69	Vacuolated lymphocytes (HP:0001922)	2.06442831
70	Postnatal microcephaly (HP:0005484)	2.06013178
71	Hypoplasia of dental enamel (HP:0006297)	2.05996097
72	Premature loss of primary teeth (HP:0006323)	2.05777628
73	Biliary tract neoplasm (HP:0100574)	2.01403762
74	Abnormality of the dental pulp (HP:0006479)	2.00121956
75	Arterial tortuosity (HP:0005116)	1.99573938
76	Increased serum ferritin (HP:0003281)	1.94605863
77	Back pain (HP:0003418)	1.93276266
78	Impaired social interactions (HP:0000735)	1.89941777
79	Abnormal social behavior (HP:0012433)	1.89941777
80	Abnormality of the intrinsic pathway (HP:0010989)	1.89366147
81	Epidermoid cyst (HP:0200040)	1.88907301
82	Polar cataract (HP:0010696)	1.88218168
83	Ankle contracture (HP:0006466)	1.87654565
84	Abnormality of the costochondral junction (HP:0000919)	1.86385350
85	Cortical visual impairment (HP:0100704)	1.84731878
86	Macroorchidism (HP:0000053)	1.81128418
87	Symptomatic seizures (HP:0011145)	1.80381240
88	Vascular tortuosity (HP:0004948)	1.79783806
89	Protrusio acetabuli (HP:0003179)	1.79548978
90	Striae distensae (HP:0001065)	1.79163422
91	Fatigue (HP:0012378)	1.78630437
92	Xanthomatosis (HP:0000991)	1.77324370
93	Gingival overgrowth (HP:0000212)	1.76617471
94	Milia (HP:0001056)	1.76210934
95	Onycholysis (HP:0001806)	1.74593991
96	Abnormality of the anterior chamber (HP:0000593)	1.74200414
97	Esophageal varix (HP:0002040)	1.72413907
98	Increased serum pyruvate (HP:0003542)	1.72077005
99	Abnormality of glycolysis (HP:0004366)	1.72077005
100	Irritability (HP:0000737)	1.71110601

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK1	5.64009067
2	CAMK1D	5.52338387
3	PKN2	5.43387601
4	TRIB3	4.42369372
5	CAMK1G	4.39413532
6	EEF2K	3.46657519
7	PDK4	2.78974459
8	PDK3	2.78974459
9	ERN1	2.61836366
10	NME2	2.37855320
11	PTK6	2.30207747
12	PIK3CA	1.97547492
13	BCKDK	1.97082373
14	RIPK1	1.83669631
15	PDK2	1.82696800
16	PDGFRB	1.76697011
17	LATS1	1.65710697
18	TGFBR2	1.54039645
19	MAPKAPK3	1.52029841
20	EPHB1	1.49287618
21	ZAP70	1.49097057
22	DAPK2	1.48204631
23	PRKAA2	1.45528370
24	RET	1.42011805
25	LRRK2	1.33111836
26	MAP3K7	1.30831569
27	STK39	1.14487366
28	STK38	1.08289449
29	DDR2	1.07710136
30	BMX	0.98472132
31	EPHA3	0.93611302
32	RPS6KB2	0.91997230
33	WNK4	0.90334233
34	TRPM7	0.83867841
35	FRK	0.78998652
36	FER	0.78046044
37	STK38L	0.71476891
38	MAPKAPK5	0.71459353
39	PTK2	0.68135769
40	MATK	0.67921374
41	PRKAA1	0.67748849
42	TBK1	0.65771841
43	MAPK12	0.65347708
44	GSK3A	0.65161398
45	JAK2	0.63240304
46	CAMK1	0.61959753
47	MYLK	0.60513091
48	JAK3	0.58730228
49	MET	0.57981494
50	MAP3K2	0.56965823
51	PDGFRA	0.56290587
52	JAK1	0.54136856
53	FLT3	0.53590899
54	TYRO3	0.53262865
55	IGF1R	0.52131375
56	RPS6KA2	0.49366393
57	CSNK1A1	0.47805345
58	FGFR4	0.47722057
59	CSF1R	0.47495297
60	CAMKK1	0.46248819
61	FGR	0.43514783
62	PDPK1	0.42717776
63	LMTK2	0.41964934
64	PAK2	0.41129525
65	MTOR	0.40701543
66	PDK1	0.39862905
67	STK3	0.38181163
68	MAPK11	0.37271996
69	PRKD1	0.37073839
70	RPS6KB1	0.32128083
71	ILK	0.31714048
72	PTK2B	0.30948920
73	GRK6	0.30921836
74	NEK9	0.30483942
75	DAPK3	0.29260425
76	LATS2	0.29046982
77	SRC	0.28527457
78	TTN	0.28062182
79	IRAK3	0.27530298
80	KSR2	0.27244209
81	CSK	0.26964064
82	PRKCZ	0.26705845
83	PIM1	0.25371460
84	SCYL2	0.24714093
85	MST1R	0.23960305
86	EGFR	0.23604108
87	FGFR3	0.21019518
88	SGK494	0.20839731
89	SGK223	0.20839731
90	WNK1	0.19584225
91	CDK6	0.19568033
92	BTK	0.18452679
93	DAPK1	0.14638581
94	TIE1	0.14607318
95	MAP3K1	0.13963811
96	KIT	0.13899512
97	INSR	0.12932709
98	PIK3CG	0.12082844
99	CHUK	0.11573618
100	PRKACG	0.09597163

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	9.31791925
2	Caffeine metabolism_Homo sapiens_hsa00232	8.53406824
3	Galactose metabolism_Homo sapiens_hsa00052	3.32181386
4	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.18141331
5	Fatty acid metabolism_Homo sapiens_hsa01212	2.61055439
6	Propanoate metabolism_Homo sapiens_hsa00640	2.35176301
7	Pyruvate metabolism_Homo sapiens_hsa00620	2.15897137
8	Prolactin signaling pathway_Homo sapiens_hsa04917	2.03610939
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.71549337
10	PPAR signaling pathway_Homo sapiens_hsa03320	1.69478207
11	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.64653003
12	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.60924465
13	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.21202844
14	Fatty acid elongation_Homo sapiens_hsa00062	1.15676961
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.15264104
16	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.14629011
17	Fatty acid degradation_Homo sapiens_hsa00071	1.05562796
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01299544
19	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.00071275
20	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.96185319
21	Carbon metabolism_Homo sapiens_hsa01200	0.90555017
22	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.88326712
23	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.82311159
24	Protein export_Homo sapiens_hsa03060	0.82141951
25	AMPK signaling pathway_Homo sapiens_hsa04152	0.79670841
26	Insulin resistance_Homo sapiens_hsa04931	0.75445897
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74804451
28	Fat digestion and absorption_Homo sapiens_hsa04975	0.74548070
29	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.69427451
30	Peroxisome_Homo sapiens_hsa04146	0.68797490
31	Sulfur relay system_Homo sapiens_hsa04122	0.67440511
32	Pentose phosphate pathway_Homo sapiens_hsa00030	0.65745734
33	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63805803
34	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.49468813
35	Arginine biosynthesis_Homo sapiens_hsa00220	0.48906708
36	Folate biosynthesis_Homo sapiens_hsa00790	0.46404116
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.45392380
38	Insulin signaling pathway_Homo sapiens_hsa04910	0.44796467
39	Butanoate metabolism_Homo sapiens_hsa00650	0.44130921
40	Amoebiasis_Homo sapiens_hsa05146	0.43949078
41	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.43805417
42	Glucagon signaling pathway_Homo sapiens_hsa04922	0.41765639
43	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.38991751
44	mTOR signaling pathway_Homo sapiens_hsa04150	0.38977202
45	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.37497054
46	Pancreatic cancer_Homo sapiens_hsa05212	0.37486105
47	Gastric acid secretion_Homo sapiens_hsa04971	0.36403876
48	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.36009174
49	ECM-receptor interaction_Homo sapiens_hsa04512	0.34989010
50	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.34374072
51	Acute myeloid leukemia_Homo sapiens_hsa05221	0.33991797
52	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.33341019
53	Toxoplasmosis_Homo sapiens_hsa05145	0.33190996
54	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.32039028
55	Vibrio cholerae infection_Homo sapiens_hsa05110	0.31236148
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.31146321
57	Mineral absorption_Homo sapiens_hsa04978	0.30406639
58	Hepatitis C_Homo sapiens_hsa05160	0.28975176
59	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.28118107
60	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27135105
61	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.26507144
62	Tight junction_Homo sapiens_hsa04530	0.26398932
63	Endocytosis_Homo sapiens_hsa04144	0.25587286
64	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.24736897
65	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.24336147
66	Focal adhesion_Homo sapiens_hsa04510	0.23971886
67	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.23889332
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.23752202
69	Bile secretion_Homo sapiens_hsa04976	0.23241206
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.22523551
71	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.22347815
72	VEGF signaling pathway_Homo sapiens_hsa04370	0.21356000
73	Lysosome_Homo sapiens_hsa04142	0.20816295
74	Small cell lung cancer_Homo sapiens_hsa05222	0.20641457
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.19982643
76	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.19784049
77	Rheumatoid arthritis_Homo sapiens_hsa05323	0.19714395
78	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.19380950
79	Renal cell carcinoma_Homo sapiens_hsa05211	0.17647474
80	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.17194636
81	Bladder cancer_Homo sapiens_hsa05219	0.16471431
82	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.15901052
83	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.15848008
84	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.14338744
85	Colorectal cancer_Homo sapiens_hsa05210	0.12813544
86	Phagosome_Homo sapiens_hsa04145	0.12102645
87	Proteoglycans in cancer_Homo sapiens_hsa05205	0.10635323
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.10250183
89	Renin secretion_Homo sapiens_hsa04924	0.08739647
90	Endometrial cancer_Homo sapiens_hsa05213	0.08693188
91	ABC transporters_Homo sapiens_hsa02010	0.07781201
92	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.07731982
93	Tuberculosis_Homo sapiens_hsa05152	0.07576407
94	Hepatitis B_Homo sapiens_hsa05161	0.07499304
95	Type II diabetes mellitus_Homo sapiens_hsa04930	0.07481110
96	Metabolic pathways_Homo sapiens_hsa01100	0.06741691
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.06013507
98	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.05765820
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.05732217
100	Tryptophan metabolism_Homo sapiens_hsa00380	0.05477968

GLYCAM1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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