GMCL1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T cell receptor signaling pathway (GO:0050860)9.58688581
2protein-chromophore linkage (GO:0018298)8.17890753
3negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)7.68945361
4multicellular organismal reproductive behavior (GO:0033057)6.94212803
5relaxation of smooth muscle (GO:0044557)6.91387680
6negative regulation of myotube differentiation (GO:0010832)6.88366980
7pyrimidine-containing compound transmembrane transport (GO:0072531)6.31375072
8phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)6.03246352
9adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.95714836
10regulation of T cell receptor signaling pathway (GO:0050856)5.78353725
11meiotic chromosome segregation (GO:0045132)5.66334105
12long term synaptic depression (GO:0060292)5.18755087
13NLS-bearing protein import into nucleus (GO:0006607)5.14210566
14mitochondrial calcium ion transport (GO:0006851)5.09622897
15positive regulation of mitochondrial calcium ion concentration (GO:0051561)5.06437240
16activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO5.00442557
17multi-organism reproductive behavior (GO:0044705)4.86964031
18transmission of nerve impulse (GO:0019226)4.85896127
19regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)4.83431438
20reproductive behavior (GO:0019098)4.78715757
21viral entry into host cell (GO:0046718)4.55256359
22positive regulation of extracellular matrix organization (GO:1903055)4.41202384
23nephron tubule formation (GO:0072079)4.38687044
24synaptic transmission, dopaminergic (GO:0001963)4.38529634
25S-adenosylmethionine metabolic process (GO:0046500)4.33460165
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.31532230
27regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.22909019
28regulation of DNA-templated transcription, initiation (GO:2000142)4.16310816
29ectodermal placode formation (GO:0060788)3.95533811
30intestinal epithelial cell development (GO:0060576)3.94128000
31positive regulation of interleukin-2 production (GO:0032743)3.92566837
32vitamin transmembrane transport (GO:0035461)3.89966445
33indolalkylamine metabolic process (GO:0006586)3.82584646
34lung epithelial cell differentiation (GO:0060487)3.81136963
35attachment of spindle microtubules to kinetochore (GO:0008608)3.80510031
36L-methionine salvage (GO:0071267)3.73401059
37L-methionine biosynthetic process (GO:0071265)3.73401059
38amino acid salvage (GO:0043102)3.73401059
39negative regulation of smooth muscle contraction (GO:0045986)3.72140866
40proline biosynthetic process (GO:0006561)3.68130584
41lung cell differentiation (GO:0060479)3.66533662
42methionine biosynthetic process (GO:0009086)3.60249544
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.57074120
44response to host immune response (GO:0052572)3.57074120
45entry into host cell (GO:0030260)3.46931693
46movement in environment of other organism involved in symbiotic interaction (GO:0052192)3.46931693
47entry into cell of other organism involved in symbiotic interaction (GO:0051806)3.46931693
48entry into host (GO:0044409)3.46931693
49entry into other organism involved in symbiotic interaction (GO:0051828)3.46931693
50movement in host environment (GO:0052126)3.46931693
51hydrogen peroxide catabolic process (GO:0042744)3.44504510
52multicellular organism reproduction (GO:0032504)3.43891907
53mitochondrial calcium ion homeostasis (GO:0051560)3.41678235
54positive regulation of male gonad development (GO:2000020)3.40505314
55cytoplasmic microtubule organization (GO:0031122)3.29256621
56otic vesicle formation (GO:0030916)3.28536451
57lipopolysaccharide biosynthetic process (GO:0009103)3.27481367
58cellular protein complex localization (GO:0034629)3.27177358
59positive regulation of uterine smooth muscle contraction (GO:0070474)3.23172044
60positive regulation of cGMP biosynthetic process (GO:0030828)3.20579235
61sensory perception of chemical stimulus (GO:0007606)3.17810430
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17608207
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.17608207
64NADH dehydrogenase complex assembly (GO:0010257)3.17608207
65ectoderm development (GO:0007398)3.16158160
66pyrimidine nucleoside salvage (GO:0043097)3.13914339
67pyrimidine-containing compound salvage (GO:0008655)3.13914339
68tryptophan metabolic process (GO:0006568)3.13872323
69deoxyribonucleotide catabolic process (GO:0009264)3.11299990
70methionine metabolic process (GO:0006555)3.10677433
71proline metabolic process (GO:0006560)3.09258365
72detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.05944377
73nitric oxide mediated signal transduction (GO:0007263)3.04096129
74indole-containing compound catabolic process (GO:0042436)3.03388627
75indolalkylamine catabolic process (GO:0046218)3.03388627
76tryptophan catabolic process (GO:0006569)3.03388627
77nucleotide transmembrane transport (GO:1901679)3.02944418
78tricarboxylic acid cycle (GO:0006099)3.02344548
79gonadal mesoderm development (GO:0007506)3.02319070
80negative regulation of stress fiber assembly (GO:0051497)3.01554988
81sulfur amino acid biosynthetic process (GO:0000097)3.01322712
82deoxyribose phosphate catabolic process (GO:0046386)3.00269040
83response to host (GO:0075136)3.00065861
84response to host defenses (GO:0052200)3.00065861
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00065861
86negative regulation of actin filament bundle assembly (GO:0032232)2.99490994
87regulation of cGMP biosynthetic process (GO:0030826)2.98110127
88thyroid gland development (GO:0030878)2.96341754
89cardiolipin metabolic process (GO:0032048)2.89870311
90startle response (GO:0001964)2.88189163
91regulation of metalloenzyme activity (GO:0048552)2.87503952
92aspartate family amino acid biosynthetic process (GO:0009067)2.86503513
93detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.85674411
94glomerular visceral epithelial cell development (GO:0072015)2.81878844
95regulation of male gonad development (GO:2000018)2.80336123
96regulation of cGMP metabolic process (GO:0030823)2.79913637
97negative regulation of striated muscle cell differentiation (GO:0051154)2.79226648
98kynurenine metabolic process (GO:0070189)2.75434416
99regulation of female receptivity (GO:0045924)17.2320013
100female mating behavior (GO:0060180)15.1092785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.09439505
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.33329200
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94366379
4GBX2_23144817_ChIP-Seq_PC3_Human2.80243588
5VDR_22108803_ChIP-Seq_LS180_Human2.76721121
6FUS_26573619_Chip-Seq_HEK293_Human2.72981616
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.65439233
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53977971
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.51183390
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51183390
11EWS_26573619_Chip-Seq_HEK293_Human2.36314803
12EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.27792948
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05993288
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04773361
15P300_19829295_ChIP-Seq_ESCs_Human2.02458458
16MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human2.01176199
17FOXA1_21572438_ChIP-Seq_LNCaP_Human1.96717330
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87893283
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.82904744
20TP53_22573176_ChIP-Seq_HFKS_Human1.76945714
21VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.76824040
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69707869
23PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.69036135
24ER_23166858_ChIP-Seq_MCF-7_Human1.68679820
25TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.68445775
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.67506923
27NANOG_19829295_ChIP-Seq_ESCs_Human1.65643895
28SOX2_19829295_ChIP-Seq_ESCs_Human1.65643895
29TCF4_22108803_ChIP-Seq_LS180_Human1.64531683
30ETV2_25802403_ChIP-Seq_MESCs_Mouse1.62595531
31IGF1R_20145208_ChIP-Seq_DFB_Human1.61972704
32TCF4_23295773_ChIP-Seq_U87_Human1.54394460
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52327079
34HOXB7_26014856_ChIP-Seq_BT474_Human1.47898617
35AR_21572438_ChIP-Seq_LNCaP_Human1.47848870
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.46853970
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43527364
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43137772
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39363545
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39282882
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36730551
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36296029
43AR_20517297_ChIP-Seq_VCAP_Human1.36260219
44LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35579233
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34684113
46FLI1_21867929_ChIP-Seq_TH2_Mouse1.32412439
47MYC_18940864_ChIP-ChIP_HL60_Human1.32289443
48FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.31401400
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30862805
50TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.29990747
51GATA3_21867929_ChIP-Seq_TH1_Mouse1.27220853
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26677707
53P53_21459846_ChIP-Seq_SAOS-2_Human1.25966859
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22914442
55SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21456851
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.20820920
57STAT3_23295773_ChIP-Seq_U87_Human1.20359392
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.19913562
59FOXH1_21741376_ChIP-Seq_ESCs_Human1.19555286
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19184365
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19141576
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18442744
63TAF15_26573619_Chip-Seq_HEK293_Human1.18141344
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.16510285
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16510285
66GATA3_26560356_Chip-Seq_TH2_Human1.15920101
67TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.15646537
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15129383
69TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14510631
70FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.14388175
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.14128980
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.13430696
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13265086
74ZNF274_21170338_ChIP-Seq_K562_Hela1.11407374
75CBP_21632823_ChIP-Seq_H3396_Human1.10030531
76NCOR_22424771_ChIP-Seq_293T_Human1.08682007
77BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.07778809
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.07706164
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06248988
80CBP_20019798_ChIP-Seq_JUKART_Human1.06248988
81PHF8_20622853_ChIP-Seq_HELA_Human1.04780978
82SMAD4_21799915_ChIP-Seq_A2780_Human1.03068459
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03003514
84AR_21909140_ChIP-Seq_LNCAP_Human1.02151136
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.00503400
86TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99969785
87CRX_20693478_ChIP-Seq_RETINA_Mouse0.99786653
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98999167
89PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97538457
90GATA6_21074721_ChIP-Seq_CACO-2_Human0.97127033
91NFYB_21822215_ChIP-Seq_K562_Human0.97116521
92E2F1_18555785_Chip-Seq_ESCs_Mouse0.96503866
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93940717
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93796988
95ERG_20517297_ChIP-Seq_VCAP_Human0.92763905
96RAC3_21632823_ChIP-Seq_H3396_Human0.92671937
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91647220
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90526946
99P300_18555785_Chip-Seq_ESCs_Mouse0.90181927
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90105755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.52642597
2MP0009780_abnormal_chondrocyte_physiolo8.29038091
3MP0002132_abnormal_respiratory_system4.82373853
4MP0000372_irregular_coat_pigmentation4.62123311
5MP0002163_abnormal_gland_morphology4.36803823
6MP0005187_abnormal_penis_morphology3.31056502
7MP0003879_abnormal_hair_cell3.29753081
8MP0005379_endocrine/exocrine_gland_phen2.97207847
9MP0004885_abnormal_endolymph2.72380093
10MP0006276_abnormal_autonomic_nervous2.71366981
11MP0004130_abnormal_muscle_cell2.68370430
12MP0002653_abnormal_ependyma_morphology2.60037415
13MP0002909_abnormal_adrenal_gland2.58317136
14MP0004381_abnormal_hair_follicle2.58269945
15MP0004147_increased_porphyrin_level1.92837339
16MP0002138_abnormal_hepatobiliary_system1.90135857
17MP0005360_urolithiasis1.83894765
18MP0010030_abnormal_orbit_morphology1.78051640
19MP0003938_abnormal_ear_development1.69409724
20MP0002009_preneoplasia1.67710195
21MP0005410_abnormal_fertilization1.63640413
22MP0002090_abnormal_vision1.51551478
23MP0000647_abnormal_sebaceous_gland1.42002039
24MP0008775_abnormal_heart_ventricle1.41026872
25MP0000681_abnormal_thyroid_gland1.39287956
26MP0001968_abnormal_touch/_nociception1.30104277
27MP0001851_eye_inflammation1.27887592
28MP0005645_abnormal_hypothalamus_physiol1.15945967
29MP0003638_abnormal_response/metabolism_1.15554746
30MP0009697_abnormal_copulation1.13916454
31MP0005551_abnormal_eye_electrophysiolog1.13526837
32MP0001346_abnormal_lacrimal_gland1.11336458
33MP0006036_abnormal_mitochondrial_physio1.09862027
34MP0000230_abnormal_systemic_arterial1.09620387
35MP0002166_altered_tumor_susceptibility1.09584308
36MP0002006_tumorigenesis1.09522613
37MP0006072_abnormal_retinal_apoptosis1.08884022
38MP0001485_abnormal_pinna_reflex1.06583506
39MP0004043_abnormal_pH_regulation1.06453248
40MP0006035_abnormal_mitochondrial_morpho0.97304040
41MP0002233_abnormal_nose_morphology0.95880507
42MP0002736_abnormal_nociception_after0.94694301
43MP0000631_abnormal_neuroendocrine_gland0.92087347
44MP0001299_abnormal_eye_distance/0.88464076
45MP0003866_abnormal_defecation0.84666032
46MP0000049_abnormal_middle_ear0.81632812
47MP0003045_fibrosis0.79605135
48MP0009046_muscle_twitch0.79322121
49MP0003646_muscle_fatigue0.78878739
50MP0005253_abnormal_eye_physiology0.75757927
51MP0001764_abnormal_homeostasis0.75043466
52MP0003195_calcinosis0.72269356
53MP0008875_abnormal_xenobiotic_pharmacok0.72076253
54MP0005171_absent_coat_pigmentation0.70488453
55MP0004085_abnormal_heartbeat0.70368774
56MP0005535_abnormal_body_temperature0.70033916
57MP0002938_white_spotting0.69759131
58MP0003119_abnormal_digestive_system0.69039625
59MP0001727_abnormal_embryo_implantation0.68577543
60MP0000383_abnormal_hair_follicle0.66911280
61MP0001501_abnormal_sleep_pattern0.66301774
62MP0002282_abnormal_trachea_morphology0.65829123
63MP0001963_abnormal_hearing_physiology0.64543317
64MP0008872_abnormal_physiological_respon0.62992352
65MP0003252_abnormal_bile_duct0.60491940
66MP0009765_abnormal_xenobiotic_induced0.60022452
67MP0003122_maternal_imprinting0.59562643
68MP0002822_catalepsy0.59181660
69MP0003567_abnormal_fetal_cardiomyocyte0.59089992
70MP0005646_abnormal_pituitary_gland0.57855415
71MP0001348_abnormal_lacrimal_gland0.55128512
72MP0008877_abnormal_DNA_methylation0.54222029
73MP0003137_abnormal_impulse_conducting0.53350493
74MP0005670_abnormal_white_adipose0.53116436
75MP0001756_abnormal_urination0.52872792
76MP0002876_abnormal_thyroid_physiology0.52485632
77MP0002998_abnormal_bone_remodeling0.51497723
78MP0001533_abnormal_skeleton_physiology0.51259289
79MP0010329_abnormal_lipoprotein_level0.49024685
80MP0005584_abnormal_enzyme/coenzyme_acti0.47141394
81MP0002160_abnormal_reproductive_system0.46761611
82MP0003718_maternal_effect0.46017853
83MP0005503_abnormal_tendon_morphology0.45930797
84MP0004924_abnormal_behavior0.45308882
85MP0005386_behavior/neurological_phenoty0.45308882
86MP0002249_abnormal_larynx_morphology0.42733397
87MP0003698_abnormal_male_reproductive0.41375205
88MP0003315_abnormal_perineum_morphology0.41024266
89MP0002118_abnormal_lipid_homeostasis0.40833852
90MP0002693_abnormal_pancreas_physiology0.40759253
91MP0002210_abnormal_sex_determination0.40436671
92MP0000026_abnormal_inner_ear0.40435664
93MP0000685_abnormal_immune_system0.39737862
94MP0002109_abnormal_limb_morphology0.38810571
95MP0009763_increased_sensitivity_to0.38489578
96MP0002075_abnormal_coat/hair_pigmentati0.38477075
97MP0005390_skeleton_phenotype0.37800523
98MP0000538_abnormal_urinary_bladder0.37650020
99MP0006292_abnormal_olfactory_placode0.37547182
100MP0005334_abnormal_fat_pad0.36555608

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)6.42919930
2Premature skin wrinkling (HP:0100678)6.33666963
311 pairs of ribs (HP:0000878)6.32966579
4Severe visual impairment (HP:0001141)5.51824070
5Absent eyebrow (HP:0002223)4.99072715
6Keratoconjunctivitis sicca (HP:0001097)4.82887453
7Short chin (HP:0000331)4.78023365
8Pheochromocytoma (HP:0002666)4.75723583
9Conical tooth (HP:0000698)4.75046752
10Keratoconjunctivitis (HP:0001096)4.61244195
11Abnormal rod and cone electroretinograms (HP:0008323)4.48733130
12Congenital stationary night blindness (HP:0007642)4.37141112
13Increased connective tissue (HP:0009025)4.15354643
14Neuroendocrine neoplasm (HP:0100634)4.13773786
15Anhidrosis (HP:0000970)4.00532112
16Centrally nucleated skeletal muscle fibers (HP:0003687)3.79968468
17Mesangial abnormality (HP:0001966)3.72168044
18Attenuation of retinal blood vessels (HP:0007843)3.58259793
19Brittle hair (HP:0002299)3.39526840
20Missing ribs (HP:0000921)3.38395017
21Aplasia/Hypoplasia of the fovea (HP:0008060)3.32313219
22Hypoplasia of the fovea (HP:0007750)3.32313219
23True hermaphroditism (HP:0010459)3.30273955
24Mutism (HP:0002300)3.30201295
25Shoulder girdle muscle weakness (HP:0003547)3.29176862
26Type I diabetes mellitus (HP:0100651)3.27269636
27Hemiparesis (HP:0001269)3.22235717
28Pelvic girdle muscle weakness (HP:0003749)3.20561522
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.18759715
30Abnormality of alanine metabolism (HP:0010916)3.18759715
31Hyperalaninemia (HP:0003348)3.18759715
32Pigmentary retinal degeneration (HP:0001146)3.18623407
33Prominent supraorbital ridges (HP:0000336)3.01582296
34Neonatal respiratory distress (HP:0002643)3.00393879
35Abnormal tarsal ossification (HP:0008369)2.98400239
36Hypoproteinemia (HP:0003075)2.95793467
37Tubular atrophy (HP:0000092)2.90987620
38Relative macrocephaly (HP:0004482)2.90687230
39Pancreatic cysts (HP:0001737)2.87485686
40Soft skin (HP:0000977)2.79064547
41Abnormality of the hip-girdle musculature (HP:0001445)2.72084340
42Abnormality of the musculature of the pelvis (HP:0001469)2.72084340
43Cerebral hemorrhage (HP:0001342)2.70956498
44Inability to walk (HP:0002540)2.70503034
45Rimmed vacuoles (HP:0003805)2.69957492
46Sparse eyelashes (HP:0000653)2.65634579
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.65435309
48Metaphyseal cupping (HP:0003021)2.65244058
49Oligodontia (HP:0000677)2.62839026
50Tinnitus (HP:0000360)2.62685915
51Abnormal biliary tract physiology (HP:0012439)2.57883148
52Bile duct proliferation (HP:0001408)2.57883148
53Abnormality of the fovea (HP:0000493)2.53559783
54Congenital hip dislocation (HP:0001374)2.49169877
55Abnormal foot bone ossification (HP:0010675)2.47650804
56Sex reversal (HP:0012245)2.45744864
57Abnormal sex determination (HP:0012244)2.45744864
58Erythroderma (HP:0001019)2.44419849
59Cerebellar dysplasia (HP:0007033)2.39221238
60Redundant skin (HP:0001582)2.39150869
61Type II lissencephaly (HP:0007260)2.35510882
62Absent hair (HP:0002298)2.34683937
63Conjunctival hamartoma (HP:0100780)2.32500823
64Bony spicule pigmentary retinopathy (HP:0007737)2.32197725
65Hypotrichosis (HP:0001006)2.31725595
66Dysphonia (HP:0001618)2.30300038
67Hypoplastic nipples (HP:0002557)2.21408456
68Abnormality of macular pigmentation (HP:0008002)2.14969074
69Respiratory difficulties (HP:0002880)2.14738362
70Abnormality of the columella (HP:0009929)2.11795891
71Hypoplastic iliac wings (HP:0002866)2.11687079
72Confusion (HP:0001289)2.11680017
73Abolished electroretinogram (ERG) (HP:0000550)2.10040848
74Progressive inability to walk (HP:0002505)2.07026473
75Aplasia/Hypoplasia of the macula (HP:0008059)2.04515477
76Neoplasm of the peripheral nervous system (HP:0100007)2.03564293
77Abnormality of male internal genitalia (HP:0000022)2.02731701
78Neonatal short-limb short stature (HP:0008921)2.00118920
79Thyroid-stimulating hormone excess (HP:0002925)1.97690195
80Pancreatic islet-cell hyperplasia (HP:0004510)1.96455388
81Abnormality of the dental root (HP:0006486)1.96081439
82Taurodontia (HP:0000679)1.96081439
83Abnormality of permanent molar morphology (HP:0011071)1.96081439
84Decreased central vision (HP:0007663)1.93937479
85Keratitis (HP:0000491)1.93696668
86Abnormality of B cell number (HP:0010975)1.93340064
87Abnormality of the dental pulp (HP:0006479)1.92983209
88Stroke (HP:0001297)1.89950635
89B lymphocytopenia (HP:0010976)1.89589869
90Palpitations (HP:0001962)1.87469059
91Abnormality of molar (HP:0011077)1.87393510
92Abnormality of molar morphology (HP:0011070)1.87393510
93Aplasia/Hypoplasia affecting the retina (HP:0008061)1.87164177
94Fibular hypoplasia (HP:0003038)1.85143418
95Increased neuronal autofluorescent lipopigment (HP:0002074)1.83204826
96Abnormality of homocysteine metabolism (HP:0010919)1.80287125
97Homocystinuria (HP:0002156)1.80287125
98Lip pit (HP:0100267)1.78544977
99Male pseudohermaphroditism (HP:0000037)1.78221970
100Cutis marmorata (HP:0000965)1.75017046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.02939086
2BUB15.71419642
3CDK124.59975499
4VRK24.04249395
5BLK3.63795792
6MAP3K103.40131506
7MST43.12726739
8ADRBK22.80066467
9KIT2.56731429
10IRAK32.41223361
11PINK12.36195403
12CLK11.73014961
13MAP3K121.71590845
14DAPK21.69619885
15EIF2AK21.59637156
16ERBB21.58281687
17KDR1.56566510
18VRK11.48758360
19TAF11.46609743
20WEE11.44804334
21TLK11.43664738
22STK31.37912382
23EIF2AK31.33421735
24SYK1.29910308
25GRK11.18484664
26WNK31.11037553
27BMPR1B1.08660959
28CSNK1G31.04190745
29PLK21.02777763
30TYRO31.00612615
31PAK30.97756945
32CSNK1A1L0.95564364
33NEK20.92471241
34TESK20.84358084
35CSNK1G10.83705069
36YES10.81406266
37TAOK30.81165481
38TXK0.80500299
39STK380.78905067
40MAP2K70.74791895
41CSNK1A10.72245940
42EPHA20.71803927
43LATS20.71269870
44ROCK10.69706635
45CSNK1G20.69511489
46TSSK60.64637970
47STK100.56425437
48PLK40.54757905
49AKT20.53210488
50MAP4K10.53072281
51CSNK2A10.51983021
52ZAK0.51604378
53CDK70.50850115
54ADRBK10.50357771
55FGFR20.49381715
56BRSK10.46149776
57LYN0.45496030
58MKNK20.45051628
59MYLK0.44190652
60PRKCE0.41885653
61IRAK40.40638187
62MAP3K10.39308595
63PLK10.37977307
64CAMKK20.37951853
65NUAK10.37939764
66LIMK10.37888979
67CDK150.37886837
68EGFR0.37791141
69PIK3CG0.37689946
70AKT10.35840726
71CDK180.34407240
72PRKACG0.34169678
73BCKDK0.33739439
74RPS6KA50.33373259
75CDK140.32890553
76PRKAA20.32081940
77ERBB30.31924092
78TRPM70.31827884
79CAMK2A0.31519343
80PRKCI0.30572714
81CDK11A0.30543060
82PRKCG0.30013619
83ATM0.29711506
84ITK0.29692273
85DYRK20.29019446
86ABL10.28713579
87RPS6KA60.28040395
88LCK0.27767542
89HIPK20.27737495
90MAPK110.27323772
91WNK40.26657235
92DAPK30.26097871
93CSNK2A20.25949269
94MAP3K80.25908279
95CAMK40.25873958
96CDK50.25234004
97PRKD10.24120773
98CAMK1D0.24018310
99DAPK10.23449950
100PIK3CA0.23153437

Predicted pathways (KEGG)

RankGene SetZ-score
1Tryptophan metabolism_Homo sapiens_hsa003804.82737305
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.78536686
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.66087133
4Sulfur relay system_Homo sapiens_hsa041223.19610799
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040803.01776502
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.72251363
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31910383
8Salivary secretion_Homo sapiens_hsa049702.12753901
9RNA polymerase_Homo sapiens_hsa030202.06948487
10Caffeine metabolism_Homo sapiens_hsa002322.03419821
11Steroid hormone biosynthesis_Homo sapiens_hsa001401.97899582
12Vitamin digestion and absorption_Homo sapiens_hsa049771.81334421
13Basal transcription factors_Homo sapiens_hsa030221.75972802
14One carbon pool by folate_Homo sapiens_hsa006701.70659902
15Nicotine addiction_Homo sapiens_hsa050331.70580400
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68812330
17Chemical carcinogenesis_Homo sapiens_hsa052041.58869581
18RNA degradation_Homo sapiens_hsa030181.49858451
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48123148
20Olfactory transduction_Homo sapiens_hsa047401.46640152
21Retinol metabolism_Homo sapiens_hsa008301.43463939
22Pentose phosphate pathway_Homo sapiens_hsa000301.37893626
23Circadian entrainment_Homo sapiens_hsa047131.36117897
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.35415112
25Purine metabolism_Homo sapiens_hsa002301.34401025
26Homologous recombination_Homo sapiens_hsa034401.32262630
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31489278
28Fatty acid biosynthesis_Homo sapiens_hsa000611.30560537
29Butanoate metabolism_Homo sapiens_hsa006501.28945187
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26116876
31Arginine and proline metabolism_Homo sapiens_hsa003301.25351438
32Pyrimidine metabolism_Homo sapiens_hsa002401.24737867
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.22110268
34Calcium signaling pathway_Homo sapiens_hsa040201.21976844
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14634176
36Primary immunodeficiency_Homo sapiens_hsa053401.14461318
37Renin secretion_Homo sapiens_hsa049241.13610866
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09976609
39Lysine degradation_Homo sapiens_hsa003101.08133661
40Systemic lupus erythematosus_Homo sapiens_hsa053221.05502116
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05467058
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.00974947
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.00674668
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96832306
45Linoleic acid metabolism_Homo sapiens_hsa005910.90158727
46Non-homologous end-joining_Homo sapiens_hsa034500.85676190
47Long-term depression_Homo sapiens_hsa047300.84015023
48Alcoholism_Homo sapiens_hsa050340.83330519
49Fatty acid degradation_Homo sapiens_hsa000710.81156942
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79523170
51Taste transduction_Homo sapiens_hsa047420.79364515
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79211161
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75326061
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75021394
55cAMP signaling pathway_Homo sapiens_hsa040240.73881277
56Phototransduction_Homo sapiens_hsa047440.71246756
57Peroxisome_Homo sapiens_hsa041460.70467405
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.68572427
59Circadian rhythm_Homo sapiens_hsa047100.68540729
60Proteasome_Homo sapiens_hsa030500.66412383
61Carbon metabolism_Homo sapiens_hsa012000.65647066
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64650830
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64569460
64Graft-versus-host disease_Homo sapiens_hsa053320.64566896
65Staphylococcus aureus infection_Homo sapiens_hsa051500.63431078
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60335397
67DNA replication_Homo sapiens_hsa030300.57154389
68Folate biosynthesis_Homo sapiens_hsa007900.56807127
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.56692948
70Metabolic pathways_Homo sapiens_hsa011000.55956355
71Fatty acid metabolism_Homo sapiens_hsa012120.55871544
72Legionellosis_Homo sapiens_hsa051340.54846296
73Phenylalanine metabolism_Homo sapiens_hsa003600.53271654
74Nitrogen metabolism_Homo sapiens_hsa009100.52644959
75Asthma_Homo sapiens_hsa053100.52331697
76Tyrosine metabolism_Homo sapiens_hsa003500.50277626
77Platelet activation_Homo sapiens_hsa046110.47943620
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47529121
79GABAergic synapse_Homo sapiens_hsa047270.47459967
80Oxytocin signaling pathway_Homo sapiens_hsa049210.46628857
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45669333
82ABC transporters_Homo sapiens_hsa020100.45052996
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.42875878
84Oocyte meiosis_Homo sapiens_hsa041140.42585352
85Propanoate metabolism_Homo sapiens_hsa006400.40883221
86Arachidonic acid metabolism_Homo sapiens_hsa005900.40756886
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40184183
88Allograft rejection_Homo sapiens_hsa053300.38175546
89Glycerolipid metabolism_Homo sapiens_hsa005610.37366899
90Viral carcinogenesis_Homo sapiens_hsa052030.36826855
91Biosynthesis of amino acids_Homo sapiens_hsa012300.36811815
92Selenocompound metabolism_Homo sapiens_hsa004500.36702226
93Autoimmune thyroid disease_Homo sapiens_hsa053200.35293390
94Morphine addiction_Homo sapiens_hsa050320.34463530
95Histidine metabolism_Homo sapiens_hsa003400.34103075
96Complement and coagulation cascades_Homo sapiens_hsa046100.30744566
97Starch and sucrose metabolism_Homo sapiens_hsa005000.29048838
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28696981
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.27922243
100Tight junction_Homo sapiens_hsa045300.23987584

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