

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 9.58688581 |
| 2 | protein-chromophore linkage (GO:0018298) | 8.17890753 |
| 3 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 7.68945361 |
| 4 | multicellular organismal reproductive behavior (GO:0033057) | 6.94212803 |
| 5 | relaxation of smooth muscle (GO:0044557) | 6.91387680 |
| 6 | negative regulation of myotube differentiation (GO:0010832) | 6.88366980 |
| 7 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 6.31375072 |
| 8 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 6.03246352 |
| 9 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 5.95714836 |
| 10 | regulation of T cell receptor signaling pathway (GO:0050856) | 5.78353725 |
| 11 | meiotic chromosome segregation (GO:0045132) | 5.66334105 |
| 12 | long term synaptic depression (GO:0060292) | 5.18755087 |
| 13 | NLS-bearing protein import into nucleus (GO:0006607) | 5.14210566 |
| 14 | mitochondrial calcium ion transport (GO:0006851) | 5.09622897 |
| 15 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 5.06437240 |
| 16 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 5.00442557 |
| 17 | multi-organism reproductive behavior (GO:0044705) | 4.86964031 |
| 18 | transmission of nerve impulse (GO:0019226) | 4.85896127 |
| 19 | regulation of transcription initiation from RNA polymerase II promoter (GO:0060260) | 4.83431438 |
| 20 | reproductive behavior (GO:0019098) | 4.78715757 |
| 21 | viral entry into host cell (GO:0046718) | 4.55256359 |
| 22 | positive regulation of extracellular matrix organization (GO:1903055) | 4.41202384 |
| 23 | nephron tubule formation (GO:0072079) | 4.38687044 |
| 24 | synaptic transmission, dopaminergic (GO:0001963) | 4.38529634 |
| 25 | S-adenosylmethionine metabolic process (GO:0046500) | 4.33460165 |
| 26 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.31532230 |
| 27 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.22909019 |
| 28 | regulation of DNA-templated transcription, initiation (GO:2000142) | 4.16310816 |
| 29 | ectodermal placode formation (GO:0060788) | 3.95533811 |
| 30 | intestinal epithelial cell development (GO:0060576) | 3.94128000 |
| 31 | positive regulation of interleukin-2 production (GO:0032743) | 3.92566837 |
| 32 | vitamin transmembrane transport (GO:0035461) | 3.89966445 |
| 33 | indolalkylamine metabolic process (GO:0006586) | 3.82584646 |
| 34 | lung epithelial cell differentiation (GO:0060487) | 3.81136963 |
| 35 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.80510031 |
| 36 | L-methionine salvage (GO:0071267) | 3.73401059 |
| 37 | L-methionine biosynthetic process (GO:0071265) | 3.73401059 |
| 38 | amino acid salvage (GO:0043102) | 3.73401059 |
| 39 | negative regulation of smooth muscle contraction (GO:0045986) | 3.72140866 |
| 40 | proline biosynthetic process (GO:0006561) | 3.68130584 |
| 41 | lung cell differentiation (GO:0060479) | 3.66533662 |
| 42 | methionine biosynthetic process (GO:0009086) | 3.60249544 |
| 43 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.57074120 |
| 44 | response to host immune response (GO:0052572) | 3.57074120 |
| 45 | entry into host cell (GO:0030260) | 3.46931693 |
| 46 | movement in environment of other organism involved in symbiotic interaction (GO:0052192) | 3.46931693 |
| 47 | entry into cell of other organism involved in symbiotic interaction (GO:0051806) | 3.46931693 |
| 48 | entry into host (GO:0044409) | 3.46931693 |
| 49 | entry into other organism involved in symbiotic interaction (GO:0051828) | 3.46931693 |
| 50 | movement in host environment (GO:0052126) | 3.46931693 |
| 51 | hydrogen peroxide catabolic process (GO:0042744) | 3.44504510 |
| 52 | multicellular organism reproduction (GO:0032504) | 3.43891907 |
| 53 | mitochondrial calcium ion homeostasis (GO:0051560) | 3.41678235 |
| 54 | positive regulation of male gonad development (GO:2000020) | 3.40505314 |
| 55 | cytoplasmic microtubule organization (GO:0031122) | 3.29256621 |
| 56 | otic vesicle formation (GO:0030916) | 3.28536451 |
| 57 | lipopolysaccharide biosynthetic process (GO:0009103) | 3.27481367 |
| 58 | cellular protein complex localization (GO:0034629) | 3.27177358 |
| 59 | positive regulation of uterine smooth muscle contraction (GO:0070474) | 3.23172044 |
| 60 | positive regulation of cGMP biosynthetic process (GO:0030828) | 3.20579235 |
| 61 | sensory perception of chemical stimulus (GO:0007606) | 3.17810430 |
| 62 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.17608207 |
| 63 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.17608207 |
| 64 | NADH dehydrogenase complex assembly (GO:0010257) | 3.17608207 |
| 65 | ectoderm development (GO:0007398) | 3.16158160 |
| 66 | pyrimidine nucleoside salvage (GO:0043097) | 3.13914339 |
| 67 | pyrimidine-containing compound salvage (GO:0008655) | 3.13914339 |
| 68 | tryptophan metabolic process (GO:0006568) | 3.13872323 |
| 69 | deoxyribonucleotide catabolic process (GO:0009264) | 3.11299990 |
| 70 | methionine metabolic process (GO:0006555) | 3.10677433 |
| 71 | proline metabolic process (GO:0006560) | 3.09258365 |
| 72 | detection of chemical stimulus involved in sensory perception of taste (GO:0050912) | 3.05944377 |
| 73 | nitric oxide mediated signal transduction (GO:0007263) | 3.04096129 |
| 74 | indole-containing compound catabolic process (GO:0042436) | 3.03388627 |
| 75 | indolalkylamine catabolic process (GO:0046218) | 3.03388627 |
| 76 | tryptophan catabolic process (GO:0006569) | 3.03388627 |
| 77 | nucleotide transmembrane transport (GO:1901679) | 3.02944418 |
| 78 | tricarboxylic acid cycle (GO:0006099) | 3.02344548 |
| 79 | gonadal mesoderm development (GO:0007506) | 3.02319070 |
| 80 | negative regulation of stress fiber assembly (GO:0051497) | 3.01554988 |
| 81 | sulfur amino acid biosynthetic process (GO:0000097) | 3.01322712 |
| 82 | deoxyribose phosphate catabolic process (GO:0046386) | 3.00269040 |
| 83 | response to host (GO:0075136) | 3.00065861 |
| 84 | response to host defenses (GO:0052200) | 3.00065861 |
| 85 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.00065861 |
| 86 | negative regulation of actin filament bundle assembly (GO:0032232) | 2.99490994 |
| 87 | regulation of cGMP biosynthetic process (GO:0030826) | 2.98110127 |
| 88 | thyroid gland development (GO:0030878) | 2.96341754 |
| 89 | cardiolipin metabolic process (GO:0032048) | 2.89870311 |
| 90 | startle response (GO:0001964) | 2.88189163 |
| 91 | regulation of metalloenzyme activity (GO:0048552) | 2.87503952 |
| 92 | aspartate family amino acid biosynthetic process (GO:0009067) | 2.86503513 |
| 93 | detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580) | 2.85674411 |
| 94 | glomerular visceral epithelial cell development (GO:0072015) | 2.81878844 |
| 95 | regulation of male gonad development (GO:2000018) | 2.80336123 |
| 96 | regulation of cGMP metabolic process (GO:0030823) | 2.79913637 |
| 97 | negative regulation of striated muscle cell differentiation (GO:0051154) | 2.79226648 |
| 98 | kynurenine metabolic process (GO:0070189) | 2.75434416 |
| 99 | regulation of female receptivity (GO:0045924) | 17.2320013 |
| 100 | female mating behavior (GO:0060180) | 15.1092785 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.09439505 |
| 2 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 3.33329200 |
| 3 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.94366379 |
| 4 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.80243588 |
| 5 | VDR_22108803_ChIP-Seq_LS180_Human | 2.76721121 |
| 6 | FUS_26573619_Chip-Seq_HEK293_Human | 2.72981616 |
| 7 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 2.65439233 |
| 8 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.53977971 |
| 9 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 2.51183390 |
| 10 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.51183390 |
| 11 | EWS_26573619_Chip-Seq_HEK293_Human | 2.36314803 |
| 12 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 2.27792948 |
| 13 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.05993288 |
| 14 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.04773361 |
| 15 | P300_19829295_ChIP-Seq_ESCs_Human | 2.02458458 |
| 16 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 2.01176199 |
| 17 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.96717330 |
| 18 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.87893283 |
| 19 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.82904744 |
| 20 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.76945714 |
| 21 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.76824040 |
| 22 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.69707869 |
| 23 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.69036135 |
| 24 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.68679820 |
| 25 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.68445775 |
| 26 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.67506923 |
| 27 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.65643895 |
| 28 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.65643895 |
| 29 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.64531683 |
| 30 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.62595531 |
| 31 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.61972704 |
| 32 | TCF4_23295773_ChIP-Seq_U87_Human | 1.54394460 |
| 33 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.52327079 |
| 34 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.47898617 |
| 35 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.47848870 |
| 36 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.46853970 |
| 37 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.43527364 |
| 38 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.43137772 |
| 39 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.39363545 |
| 40 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.39282882 |
| 41 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.36730551 |
| 42 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.36296029 |
| 43 | AR_20517297_ChIP-Seq_VCAP_Human | 1.36260219 |
| 44 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 1.35579233 |
| 45 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.34684113 |
| 46 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.32412439 |
| 47 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.32289443 |
| 48 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.31401400 |
| 49 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.30862805 |
| 50 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.29990747 |
| 51 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 1.27220853 |
| 52 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.26677707 |
| 53 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.25966859 |
| 54 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.22914442 |
| 55 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.21456851 |
| 56 | GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.20820920 |
| 57 | STAT3_23295773_ChIP-Seq_U87_Human | 1.20359392 |
| 58 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.19913562 |
| 59 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.19555286 |
| 60 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.19184365 |
| 61 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.19141576 |
| 62 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.18442744 |
| 63 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.18141344 |
| 64 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.16510285 |
| 65 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.16510285 |
| 66 | GATA3_26560356_Chip-Seq_TH2_Human | 1.15920101 |
| 67 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.15646537 |
| 68 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.15129383 |
| 69 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.14510631 |
| 70 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 1.14388175 |
| 71 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.14128980 |
| 72 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.13430696 |
| 73 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.13265086 |
| 74 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.11407374 |
| 75 | CBP_21632823_ChIP-Seq_H3396_Human | 1.10030531 |
| 76 | NCOR_22424771_ChIP-Seq_293T_Human | 1.08682007 |
| 77 | BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human | 1.07778809 |
| 78 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.07706164 |
| 79 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.06248988 |
| 80 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.06248988 |
| 81 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.04780978 |
| 82 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.03068459 |
| 83 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.03003514 |
| 84 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.02151136 |
| 85 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.00503400 |
| 86 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.99969785 |
| 87 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.99786653 |
| 88 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.98999167 |
| 89 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.97538457 |
| 90 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.97127033 |
| 91 | NFYB_21822215_ChIP-Seq_K562_Human | 0.97116521 |
| 92 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.96503866 |
| 93 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.93940717 |
| 94 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.93796988 |
| 95 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.92763905 |
| 96 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.92671937 |
| 97 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.91647220 |
| 98 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.90526946 |
| 99 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.90181927 |
| 100 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.90105755 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003136_yellow_coat_color | 8.52642597 |
| 2 | MP0009780_abnormal_chondrocyte_physiolo | 8.29038091 |
| 3 | MP0002132_abnormal_respiratory_system | 4.82373853 |
| 4 | MP0000372_irregular_coat_pigmentation | 4.62123311 |
| 5 | MP0002163_abnormal_gland_morphology | 4.36803823 |
| 6 | MP0005187_abnormal_penis_morphology | 3.31056502 |
| 7 | MP0003879_abnormal_hair_cell | 3.29753081 |
| 8 | MP0005379_endocrine/exocrine_gland_phen | 2.97207847 |
| 9 | MP0004885_abnormal_endolymph | 2.72380093 |
| 10 | MP0006276_abnormal_autonomic_nervous | 2.71366981 |
| 11 | MP0004130_abnormal_muscle_cell | 2.68370430 |
| 12 | MP0002653_abnormal_ependyma_morphology | 2.60037415 |
| 13 | MP0002909_abnormal_adrenal_gland | 2.58317136 |
| 14 | MP0004381_abnormal_hair_follicle | 2.58269945 |
| 15 | MP0004147_increased_porphyrin_level | 1.92837339 |
| 16 | MP0002138_abnormal_hepatobiliary_system | 1.90135857 |
| 17 | MP0005360_urolithiasis | 1.83894765 |
| 18 | MP0010030_abnormal_orbit_morphology | 1.78051640 |
| 19 | MP0003938_abnormal_ear_development | 1.69409724 |
| 20 | MP0002009_preneoplasia | 1.67710195 |
| 21 | MP0005410_abnormal_fertilization | 1.63640413 |
| 22 | MP0002090_abnormal_vision | 1.51551478 |
| 23 | MP0000647_abnormal_sebaceous_gland | 1.42002039 |
| 24 | MP0008775_abnormal_heart_ventricle | 1.41026872 |
| 25 | MP0000681_abnormal_thyroid_gland | 1.39287956 |
| 26 | MP0001968_abnormal_touch/_nociception | 1.30104277 |
| 27 | MP0001851_eye_inflammation | 1.27887592 |
| 28 | MP0005645_abnormal_hypothalamus_physiol | 1.15945967 |
| 29 | MP0003638_abnormal_response/metabolism_ | 1.15554746 |
| 30 | MP0009697_abnormal_copulation | 1.13916454 |
| 31 | MP0005551_abnormal_eye_electrophysiolog | 1.13526837 |
| 32 | MP0001346_abnormal_lacrimal_gland | 1.11336458 |
| 33 | MP0006036_abnormal_mitochondrial_physio | 1.09862027 |
| 34 | MP0000230_abnormal_systemic_arterial | 1.09620387 |
| 35 | MP0002166_altered_tumor_susceptibility | 1.09584308 |
| 36 | MP0002006_tumorigenesis | 1.09522613 |
| 37 | MP0006072_abnormal_retinal_apoptosis | 1.08884022 |
| 38 | MP0001485_abnormal_pinna_reflex | 1.06583506 |
| 39 | MP0004043_abnormal_pH_regulation | 1.06453248 |
| 40 | MP0006035_abnormal_mitochondrial_morpho | 0.97304040 |
| 41 | MP0002233_abnormal_nose_morphology | 0.95880507 |
| 42 | MP0002736_abnormal_nociception_after | 0.94694301 |
| 43 | MP0000631_abnormal_neuroendocrine_gland | 0.92087347 |
| 44 | MP0001299_abnormal_eye_distance/ | 0.88464076 |
| 45 | MP0003866_abnormal_defecation | 0.84666032 |
| 46 | MP0000049_abnormal_middle_ear | 0.81632812 |
| 47 | MP0003045_fibrosis | 0.79605135 |
| 48 | MP0009046_muscle_twitch | 0.79322121 |
| 49 | MP0003646_muscle_fatigue | 0.78878739 |
| 50 | MP0005253_abnormal_eye_physiology | 0.75757927 |
| 51 | MP0001764_abnormal_homeostasis | 0.75043466 |
| 52 | MP0003195_calcinosis | 0.72269356 |
| 53 | MP0008875_abnormal_xenobiotic_pharmacok | 0.72076253 |
| 54 | MP0005171_absent_coat_pigmentation | 0.70488453 |
| 55 | MP0004085_abnormal_heartbeat | 0.70368774 |
| 56 | MP0005535_abnormal_body_temperature | 0.70033916 |
| 57 | MP0002938_white_spotting | 0.69759131 |
| 58 | MP0003119_abnormal_digestive_system | 0.69039625 |
| 59 | MP0001727_abnormal_embryo_implantation | 0.68577543 |
| 60 | MP0000383_abnormal_hair_follicle | 0.66911280 |
| 61 | MP0001501_abnormal_sleep_pattern | 0.66301774 |
| 62 | MP0002282_abnormal_trachea_morphology | 0.65829123 |
| 63 | MP0001963_abnormal_hearing_physiology | 0.64543317 |
| 64 | MP0008872_abnormal_physiological_respon | 0.62992352 |
| 65 | MP0003252_abnormal_bile_duct | 0.60491940 |
| 66 | MP0009765_abnormal_xenobiotic_induced | 0.60022452 |
| 67 | MP0003122_maternal_imprinting | 0.59562643 |
| 68 | MP0002822_catalepsy | 0.59181660 |
| 69 | MP0003567_abnormal_fetal_cardiomyocyte | 0.59089992 |
| 70 | MP0005646_abnormal_pituitary_gland | 0.57855415 |
| 71 | MP0001348_abnormal_lacrimal_gland | 0.55128512 |
| 72 | MP0008877_abnormal_DNA_methylation | 0.54222029 |
| 73 | MP0003137_abnormal_impulse_conducting | 0.53350493 |
| 74 | MP0005670_abnormal_white_adipose | 0.53116436 |
| 75 | MP0001756_abnormal_urination | 0.52872792 |
| 76 | MP0002876_abnormal_thyroid_physiology | 0.52485632 |
| 77 | MP0002998_abnormal_bone_remodeling | 0.51497723 |
| 78 | MP0001533_abnormal_skeleton_physiology | 0.51259289 |
| 79 | MP0010329_abnormal_lipoprotein_level | 0.49024685 |
| 80 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.47141394 |
| 81 | MP0002160_abnormal_reproductive_system | 0.46761611 |
| 82 | MP0003718_maternal_effect | 0.46017853 |
| 83 | MP0005503_abnormal_tendon_morphology | 0.45930797 |
| 84 | MP0004924_abnormal_behavior | 0.45308882 |
| 85 | MP0005386_behavior/neurological_phenoty | 0.45308882 |
| 86 | MP0002249_abnormal_larynx_morphology | 0.42733397 |
| 87 | MP0003698_abnormal_male_reproductive | 0.41375205 |
| 88 | MP0003315_abnormal_perineum_morphology | 0.41024266 |
| 89 | MP0002118_abnormal_lipid_homeostasis | 0.40833852 |
| 90 | MP0002693_abnormal_pancreas_physiology | 0.40759253 |
| 91 | MP0002210_abnormal_sex_determination | 0.40436671 |
| 92 | MP0000026_abnormal_inner_ear | 0.40435664 |
| 93 | MP0000685_abnormal_immune_system | 0.39737862 |
| 94 | MP0002109_abnormal_limb_morphology | 0.38810571 |
| 95 | MP0009763_increased_sensitivity_to | 0.38489578 |
| 96 | MP0002075_abnormal_coat/hair_pigmentati | 0.38477075 |
| 97 | MP0005390_skeleton_phenotype | 0.37800523 |
| 98 | MP0000538_abnormal_urinary_bladder | 0.37650020 |
| 99 | MP0006292_abnormal_olfactory_placode | 0.37547182 |
| 100 | MP0005334_abnormal_fat_pad | 0.36555608 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Concave nail (HP:0001598) | 6.42919930 |
| 2 | Premature skin wrinkling (HP:0100678) | 6.33666963 |
| 3 | 11 pairs of ribs (HP:0000878) | 6.32966579 |
| 4 | Severe visual impairment (HP:0001141) | 5.51824070 |
| 5 | Absent eyebrow (HP:0002223) | 4.99072715 |
| 6 | Keratoconjunctivitis sicca (HP:0001097) | 4.82887453 |
| 7 | Short chin (HP:0000331) | 4.78023365 |
| 8 | Pheochromocytoma (HP:0002666) | 4.75723583 |
| 9 | Conical tooth (HP:0000698) | 4.75046752 |
| 10 | Keratoconjunctivitis (HP:0001096) | 4.61244195 |
| 11 | Abnormal rod and cone electroretinograms (HP:0008323) | 4.48733130 |
| 12 | Congenital stationary night blindness (HP:0007642) | 4.37141112 |
| 13 | Increased connective tissue (HP:0009025) | 4.15354643 |
| 14 | Neuroendocrine neoplasm (HP:0100634) | 4.13773786 |
| 15 | Anhidrosis (HP:0000970) | 4.00532112 |
| 16 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 3.79968468 |
| 17 | Mesangial abnormality (HP:0001966) | 3.72168044 |
| 18 | Attenuation of retinal blood vessels (HP:0007843) | 3.58259793 |
| 19 | Brittle hair (HP:0002299) | 3.39526840 |
| 20 | Missing ribs (HP:0000921) | 3.38395017 |
| 21 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 3.32313219 |
| 22 | Hypoplasia of the fovea (HP:0007750) | 3.32313219 |
| 23 | True hermaphroditism (HP:0010459) | 3.30273955 |
| 24 | Mutism (HP:0002300) | 3.30201295 |
| 25 | Shoulder girdle muscle weakness (HP:0003547) | 3.29176862 |
| 26 | Type I diabetes mellitus (HP:0100651) | 3.27269636 |
| 27 | Hemiparesis (HP:0001269) | 3.22235717 |
| 28 | Pelvic girdle muscle weakness (HP:0003749) | 3.20561522 |
| 29 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.18759715 |
| 30 | Abnormality of alanine metabolism (HP:0010916) | 3.18759715 |
| 31 | Hyperalaninemia (HP:0003348) | 3.18759715 |
| 32 | Pigmentary retinal degeneration (HP:0001146) | 3.18623407 |
| 33 | Prominent supraorbital ridges (HP:0000336) | 3.01582296 |
| 34 | Neonatal respiratory distress (HP:0002643) | 3.00393879 |
| 35 | Abnormal tarsal ossification (HP:0008369) | 2.98400239 |
| 36 | Hypoproteinemia (HP:0003075) | 2.95793467 |
| 37 | Tubular atrophy (HP:0000092) | 2.90987620 |
| 38 | Relative macrocephaly (HP:0004482) | 2.90687230 |
| 39 | Pancreatic cysts (HP:0001737) | 2.87485686 |
| 40 | Soft skin (HP:0000977) | 2.79064547 |
| 41 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.72084340 |
| 42 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.72084340 |
| 43 | Cerebral hemorrhage (HP:0001342) | 2.70956498 |
| 44 | Inability to walk (HP:0002540) | 2.70503034 |
| 45 | Rimmed vacuoles (HP:0003805) | 2.69957492 |
| 46 | Sparse eyelashes (HP:0000653) | 2.65634579 |
| 47 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.65435309 |
| 48 | Metaphyseal cupping (HP:0003021) | 2.65244058 |
| 49 | Oligodontia (HP:0000677) | 2.62839026 |
| 50 | Tinnitus (HP:0000360) | 2.62685915 |
| 51 | Abnormal biliary tract physiology (HP:0012439) | 2.57883148 |
| 52 | Bile duct proliferation (HP:0001408) | 2.57883148 |
| 53 | Abnormality of the fovea (HP:0000493) | 2.53559783 |
| 54 | Congenital hip dislocation (HP:0001374) | 2.49169877 |
| 55 | Abnormal foot bone ossification (HP:0010675) | 2.47650804 |
| 56 | Sex reversal (HP:0012245) | 2.45744864 |
| 57 | Abnormal sex determination (HP:0012244) | 2.45744864 |
| 58 | Erythroderma (HP:0001019) | 2.44419849 |
| 59 | Cerebellar dysplasia (HP:0007033) | 2.39221238 |
| 60 | Redundant skin (HP:0001582) | 2.39150869 |
| 61 | Type II lissencephaly (HP:0007260) | 2.35510882 |
| 62 | Absent hair (HP:0002298) | 2.34683937 |
| 63 | Conjunctival hamartoma (HP:0100780) | 2.32500823 |
| 64 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.32197725 |
| 65 | Hypotrichosis (HP:0001006) | 2.31725595 |
| 66 | Dysphonia (HP:0001618) | 2.30300038 |
| 67 | Hypoplastic nipples (HP:0002557) | 2.21408456 |
| 68 | Abnormality of macular pigmentation (HP:0008002) | 2.14969074 |
| 69 | Respiratory difficulties (HP:0002880) | 2.14738362 |
| 70 | Abnormality of the columella (HP:0009929) | 2.11795891 |
| 71 | Hypoplastic iliac wings (HP:0002866) | 2.11687079 |
| 72 | Confusion (HP:0001289) | 2.11680017 |
| 73 | Abolished electroretinogram (ERG) (HP:0000550) | 2.10040848 |
| 74 | Progressive inability to walk (HP:0002505) | 2.07026473 |
| 75 | Aplasia/Hypoplasia of the macula (HP:0008059) | 2.04515477 |
| 76 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.03564293 |
| 77 | Abnormality of male internal genitalia (HP:0000022) | 2.02731701 |
| 78 | Neonatal short-limb short stature (HP:0008921) | 2.00118920 |
| 79 | Thyroid-stimulating hormone excess (HP:0002925) | 1.97690195 |
| 80 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.96455388 |
| 81 | Abnormality of the dental root (HP:0006486) | 1.96081439 |
| 82 | Taurodontia (HP:0000679) | 1.96081439 |
| 83 | Abnormality of permanent molar morphology (HP:0011071) | 1.96081439 |
| 84 | Decreased central vision (HP:0007663) | 1.93937479 |
| 85 | Keratitis (HP:0000491) | 1.93696668 |
| 86 | Abnormality of B cell number (HP:0010975) | 1.93340064 |
| 87 | Abnormality of the dental pulp (HP:0006479) | 1.92983209 |
| 88 | Stroke (HP:0001297) | 1.89950635 |
| 89 | B lymphocytopenia (HP:0010976) | 1.89589869 |
| 90 | Palpitations (HP:0001962) | 1.87469059 |
| 91 | Abnormality of molar (HP:0011077) | 1.87393510 |
| 92 | Abnormality of molar morphology (HP:0011070) | 1.87393510 |
| 93 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 1.87164177 |
| 94 | Fibular hypoplasia (HP:0003038) | 1.85143418 |
| 95 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.83204826 |
| 96 | Abnormality of homocysteine metabolism (HP:0010919) | 1.80287125 |
| 97 | Homocystinuria (HP:0002156) | 1.80287125 |
| 98 | Lip pit (HP:0100267) | 1.78544977 |
| 99 | Male pseudohermaphroditism (HP:0000037) | 1.78221970 |
| 100 | Cutis marmorata (HP:0000965) | 1.75017046 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 6.02939086 |
| 2 | BUB1 | 5.71419642 |
| 3 | CDK12 | 4.59975499 |
| 4 | VRK2 | 4.04249395 |
| 5 | BLK | 3.63795792 |
| 6 | MAP3K10 | 3.40131506 |
| 7 | MST4 | 3.12726739 |
| 8 | ADRBK2 | 2.80066467 |
| 9 | KIT | 2.56731429 |
| 10 | IRAK3 | 2.41223361 |
| 11 | PINK1 | 2.36195403 |
| 12 | CLK1 | 1.73014961 |
| 13 | MAP3K12 | 1.71590845 |
| 14 | DAPK2 | 1.69619885 |
| 15 | EIF2AK2 | 1.59637156 |
| 16 | ERBB2 | 1.58281687 |
| 17 | KDR | 1.56566510 |
| 18 | VRK1 | 1.48758360 |
| 19 | TAF1 | 1.46609743 |
| 20 | WEE1 | 1.44804334 |
| 21 | TLK1 | 1.43664738 |
| 22 | STK3 | 1.37912382 |
| 23 | EIF2AK3 | 1.33421735 |
| 24 | SYK | 1.29910308 |
| 25 | GRK1 | 1.18484664 |
| 26 | WNK3 | 1.11037553 |
| 27 | BMPR1B | 1.08660959 |
| 28 | CSNK1G3 | 1.04190745 |
| 29 | PLK2 | 1.02777763 |
| 30 | TYRO3 | 1.00612615 |
| 31 | PAK3 | 0.97756945 |
| 32 | CSNK1A1L | 0.95564364 |
| 33 | NEK2 | 0.92471241 |
| 34 | TESK2 | 0.84358084 |
| 35 | CSNK1G1 | 0.83705069 |
| 36 | YES1 | 0.81406266 |
| 37 | TAOK3 | 0.81165481 |
| 38 | TXK | 0.80500299 |
| 39 | STK38 | 0.78905067 |
| 40 | MAP2K7 | 0.74791895 |
| 41 | CSNK1A1 | 0.72245940 |
| 42 | EPHA2 | 0.71803927 |
| 43 | LATS2 | 0.71269870 |
| 44 | ROCK1 | 0.69706635 |
| 45 | CSNK1G2 | 0.69511489 |
| 46 | TSSK6 | 0.64637970 |
| 47 | STK10 | 0.56425437 |
| 48 | PLK4 | 0.54757905 |
| 49 | AKT2 | 0.53210488 |
| 50 | MAP4K1 | 0.53072281 |
| 51 | CSNK2A1 | 0.51983021 |
| 52 | ZAK | 0.51604378 |
| 53 | CDK7 | 0.50850115 |
| 54 | ADRBK1 | 0.50357771 |
| 55 | FGFR2 | 0.49381715 |
| 56 | BRSK1 | 0.46149776 |
| 57 | LYN | 0.45496030 |
| 58 | MKNK2 | 0.45051628 |
| 59 | MYLK | 0.44190652 |
| 60 | PRKCE | 0.41885653 |
| 61 | IRAK4 | 0.40638187 |
| 62 | MAP3K1 | 0.39308595 |
| 63 | PLK1 | 0.37977307 |
| 64 | CAMKK2 | 0.37951853 |
| 65 | NUAK1 | 0.37939764 |
| 66 | LIMK1 | 0.37888979 |
| 67 | CDK15 | 0.37886837 |
| 68 | EGFR | 0.37791141 |
| 69 | PIK3CG | 0.37689946 |
| 70 | AKT1 | 0.35840726 |
| 71 | CDK18 | 0.34407240 |
| 72 | PRKACG | 0.34169678 |
| 73 | BCKDK | 0.33739439 |
| 74 | RPS6KA5 | 0.33373259 |
| 75 | CDK14 | 0.32890553 |
| 76 | PRKAA2 | 0.32081940 |
| 77 | ERBB3 | 0.31924092 |
| 78 | TRPM7 | 0.31827884 |
| 79 | CAMK2A | 0.31519343 |
| 80 | PRKCI | 0.30572714 |
| 81 | CDK11A | 0.30543060 |
| 82 | PRKCG | 0.30013619 |
| 83 | ATM | 0.29711506 |
| 84 | ITK | 0.29692273 |
| 85 | DYRK2 | 0.29019446 |
| 86 | ABL1 | 0.28713579 |
| 87 | RPS6KA6 | 0.28040395 |
| 88 | LCK | 0.27767542 |
| 89 | HIPK2 | 0.27737495 |
| 90 | MAPK11 | 0.27323772 |
| 91 | WNK4 | 0.26657235 |
| 92 | DAPK3 | 0.26097871 |
| 93 | CSNK2A2 | 0.25949269 |
| 94 | MAP3K8 | 0.25908279 |
| 95 | CAMK4 | 0.25873958 |
| 96 | CDK5 | 0.25234004 |
| 97 | PRKD1 | 0.24120773 |
| 98 | CAMK1D | 0.24018310 |
| 99 | DAPK1 | 0.23449950 |
| 100 | PIK3CA | 0.23153437 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Tryptophan metabolism_Homo sapiens_hsa00380 | 4.82737305 |
| 2 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 3.78536686 |
| 3 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 3.66087133 |
| 4 | Sulfur relay system_Homo sapiens_hsa04122 | 3.19610799 |
| 5 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 3.01776502 |
| 6 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 2.72251363 |
| 7 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.31910383 |
| 8 | Salivary secretion_Homo sapiens_hsa04970 | 2.12753901 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.06948487 |
| 10 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.03419821 |
| 11 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.97899582 |
| 12 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.81334421 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 1.75972802 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.70659902 |
| 15 | Nicotine addiction_Homo sapiens_hsa05033 | 1.70580400 |
| 16 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.68812330 |
| 17 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.58869581 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.49858451 |
| 19 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.48123148 |
| 20 | Olfactory transduction_Homo sapiens_hsa04740 | 1.46640152 |
| 21 | Retinol metabolism_Homo sapiens_hsa00830 | 1.43463939 |
| 22 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.37893626 |
| 23 | Circadian entrainment_Homo sapiens_hsa04713 | 1.36117897 |
| 24 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.35415112 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.34401025 |
| 26 | Homologous recombination_Homo sapiens_hsa03440 | 1.32262630 |
| 27 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.31489278 |
| 28 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.30560537 |
| 29 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.28945187 |
| 30 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.26116876 |
| 31 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.25351438 |
| 32 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.24737867 |
| 33 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.22110268 |
| 34 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.21976844 |
| 35 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.14634176 |
| 36 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.14461318 |
| 37 | Renin secretion_Homo sapiens_hsa04924 | 1.13610866 |
| 38 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.09976609 |
| 39 | Lysine degradation_Homo sapiens_hsa00310 | 1.08133661 |
| 40 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.05502116 |
| 41 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.05467058 |
| 42 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.00974947 |
| 43 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.00674668 |
| 44 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.96832306 |
| 45 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.90158727 |
| 46 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.85676190 |
| 47 | Long-term depression_Homo sapiens_hsa04730 | 0.84015023 |
| 48 | Alcoholism_Homo sapiens_hsa05034 | 0.83330519 |
| 49 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.81156942 |
| 50 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.79523170 |
| 51 | Taste transduction_Homo sapiens_hsa04742 | 0.79364515 |
| 52 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.79211161 |
| 53 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.75326061 |
| 54 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.75021394 |
| 55 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.73881277 |
| 56 | Phototransduction_Homo sapiens_hsa04744 | 0.71246756 |
| 57 | Peroxisome_Homo sapiens_hsa04146 | 0.70467405 |
| 58 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.68572427 |
| 59 | Circadian rhythm_Homo sapiens_hsa04710 | 0.68540729 |
| 60 | Proteasome_Homo sapiens_hsa03050 | 0.66412383 |
| 61 | Carbon metabolism_Homo sapiens_hsa01200 | 0.65647066 |
| 62 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.64650830 |
| 63 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.64569460 |
| 64 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.64566896 |
| 65 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.63431078 |
| 66 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.60335397 |
| 67 | DNA replication_Homo sapiens_hsa03030 | 0.57154389 |
| 68 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.56807127 |
| 69 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.56692948 |
| 70 | Metabolic pathways_Homo sapiens_hsa01100 | 0.55956355 |
| 71 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.55871544 |
| 72 | Legionellosis_Homo sapiens_hsa05134 | 0.54846296 |
| 73 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.53271654 |
| 74 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.52644959 |
| 75 | Asthma_Homo sapiens_hsa05310 | 0.52331697 |
| 76 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.50277626 |
| 77 | Platelet activation_Homo sapiens_hsa04611 | 0.47943620 |
| 78 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47529121 |
| 79 | GABAergic synapse_Homo sapiens_hsa04727 | 0.47459967 |
| 80 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.46628857 |
| 81 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.45669333 |
| 82 | ABC transporters_Homo sapiens_hsa02010 | 0.45052996 |
| 83 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.42875878 |
| 84 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.42585352 |
| 85 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.40883221 |
| 86 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.40756886 |
| 87 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.40184183 |
| 88 | Allograft rejection_Homo sapiens_hsa05330 | 0.38175546 |
| 89 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.37366899 |
| 90 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.36826855 |
| 91 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.36811815 |
| 92 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.36702226 |
| 93 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.35293390 |
| 94 | Morphine addiction_Homo sapiens_hsa05032 | 0.34463530 |
| 95 | Histidine metabolism_Homo sapiens_hsa00340 | 0.34103075 |
| 96 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.30744566 |
| 97 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.29048838 |
| 98 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.28696981 |
| 99 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.27922243 |
| 100 | Tight junction_Homo sapiens_hsa04530 | 0.23987584 |

