GMEB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.81980463
2replication fork processing (GO:0031297)5.43077736
3maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.94813411
4kinetochore assembly (GO:0051382)4.72649328
5telomere maintenance via semi-conservative replication (GO:0032201)4.64961041
6somatic hypermutation of immunoglobulin genes (GO:0016446)4.44286724
7somatic diversification of immune receptors via somatic mutation (GO:0002566)4.44286724
8proline biosynthetic process (GO:0006561)4.36396913
9L-fucose catabolic process (GO:0042355)4.35032287
10fucose catabolic process (GO:0019317)4.35032287
11L-fucose metabolic process (GO:0042354)4.35032287
12behavioral response to nicotine (GO:0035095)4.28568941
13viral mRNA export from host cell nucleus (GO:0046784)4.28281484
14transcription from mitochondrial promoter (GO:0006390)4.28003892
15kinetochore organization (GO:0051383)4.27425144
16regulation of double-strand break repair via homologous recombination (GO:0010569)4.16247827
17DNA strand elongation involved in DNA replication (GO:0006271)4.15518442
18kynurenine metabolic process (GO:0070189)4.15352198
19telomere maintenance via recombination (GO:0000722)4.08810293
20DNA strand renaturation (GO:0000733)4.06112448
21nucleotide-excision repair, DNA gap filling (GO:0006297)4.01390425
22maturation of 5.8S rRNA (GO:0000460)3.97883273
23DNA strand elongation (GO:0022616)3.96742587
24indole-containing compound catabolic process (GO:0042436)3.89380867
25indolalkylamine catabolic process (GO:0046218)3.89380867
26tryptophan catabolic process (GO:0006569)3.89380867
27water-soluble vitamin biosynthetic process (GO:0042364)3.84044485
28poly(A)+ mRNA export from nucleus (GO:0016973)3.78585663
29positive regulation of mitotic sister chromatid separation (GO:1901970)3.77523802
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.77523802
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.77523802
32meiotic chromosome segregation (GO:0045132)3.76241002
33DNA double-strand break processing (GO:0000729)3.74384733
34DNA ligation (GO:0006266)3.72448612
35mitotic recombination (GO:0006312)3.71782485
36telomere maintenance via telomere lengthening (GO:0010833)3.71098447
37mitotic metaphase plate congression (GO:0007080)3.70272798
38negative regulation of telomere maintenance (GO:0032205)3.68279256
39regulation of nuclear cell cycle DNA replication (GO:0033262)3.63830906
40mitochondrial DNA metabolic process (GO:0032042)3.61760374
41DNA integration (GO:0015074)3.61345381
42tryptophan metabolic process (GO:0006568)3.55026396
43base-excision repair (GO:0006284)3.54841863
44histone H4-K12 acetylation (GO:0043983)3.54094204
45embryonic process involved in female pregnancy (GO:0060136)3.52513818
46neural tube formation (GO:0001841)3.51064786
47indolalkylamine metabolic process (GO:0006586)3.51033036
48proline metabolic process (GO:0006560)3.42960084
49platelet dense granule organization (GO:0060155)3.42522163
50regulation of memory T cell differentiation (GO:0043380)3.40628561
51response to pheromone (GO:0019236)3.40456263
52positive regulation of chromosome segregation (GO:0051984)3.37797095
53termination of RNA polymerase II transcription (GO:0006369)3.36851531
54positive regulation of protein homooligomerization (GO:0032464)3.36781377
55negative regulation of translation, ncRNA-mediated (GO:0040033)3.36329732
56regulation of translation, ncRNA-mediated (GO:0045974)3.36329732
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.36329732
58regulation of double-strand break repair (GO:2000779)3.31467451
59base-excision repair, AP site formation (GO:0006285)3.26764027
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25620933
61mitochondrial respiratory chain complex I assembly (GO:0032981)3.25620933
62NADH dehydrogenase complex assembly (GO:0010257)3.25620933
63formation of translation preinitiation complex (GO:0001731)3.25185404
64single strand break repair (GO:0000012)3.24388159
65spliceosomal snRNP assembly (GO:0000387)3.21901321
66proteasome assembly (GO:0043248)3.20191305
67transcription-coupled nucleotide-excision repair (GO:0006283)3.20012033
68metaphase plate congression (GO:0051310)3.19827919
69mitochondrial respiratory chain complex assembly (GO:0033108)3.18905604
70DNA topological change (GO:0006265)3.18756863
71oxidative demethylation (GO:0070989)3.18271091
72piRNA metabolic process (GO:0034587)3.17950463
73DNA replication checkpoint (GO:0000076)3.17912365
74protein complex biogenesis (GO:0070271)3.17888042
75mitochondrial DNA replication (GO:0006264)3.14953146
76regulation of sister chromatid cohesion (GO:0007063)3.10175365
77RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10150240
78negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.08577717
79DNA replication initiation (GO:0006270)3.07701000
80ribosome biogenesis (GO:0042254)3.07446065
81establishment of protein localization to mitochondrial membrane (GO:0090151)3.07351139
82double-strand break repair via nonhomologous end joining (GO:0006303)3.06034707
83non-recombinational repair (GO:0000726)3.06034707
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05866261
85mismatch repair (GO:0006298)3.05178557
86negative regulation of chromosome segregation (GO:0051985)3.04801938
87regulation of integrin activation (GO:0033623)3.02963426
88resolution of meiotic recombination intermediates (GO:0000712)3.02461964
89recombinational repair (GO:0000725)3.01655822
90negative regulation of mast cell activation (GO:0033004)3.01024271
91double-strand break repair via homologous recombination (GO:0000724)2.97965107
92respiratory chain complex IV assembly (GO:0008535)2.96244914
93mitotic sister chromatid segregation (GO:0000070)2.95902269
94adaptation of signaling pathway (GO:0023058)2.94750852
95pseudouridine synthesis (GO:0001522)2.94334187
96protein K11-linked deubiquitination (GO:0035871)2.94277228
97rRNA processing (GO:0006364)2.94035330
98rRNA modification (GO:0000154)2.92573731
99negative regulation of DNA-dependent DNA replication (GO:2000104)2.92157934
100DNA demethylation (GO:0080111)2.91846316
101regulation of DNA endoreduplication (GO:0032875)2.89763433
102DNA-templated transcription, termination (GO:0006353)2.88309212
103regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87034911
104establishment of chromosome localization (GO:0051303)2.86960291
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86855556
106rRNA metabolic process (GO:0016072)2.84778173
107protein K6-linked ubiquitination (GO:0085020)2.83201757
108negative regulation of mRNA processing (GO:0050686)2.83125281
109protein-cofactor linkage (GO:0018065)2.81749467
110positive regulation of DNA repair (GO:0045739)2.81279325
111regulation of sister chromatid segregation (GO:0033045)2.81079931
112regulation of mitotic sister chromatid separation (GO:0010965)2.81079931
113regulation of mitotic sister chromatid segregation (GO:0033047)2.81079931
114regulation of telomere maintenance (GO:0032204)2.80520903
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80302311
116DNA-dependent DNA replication (GO:0006261)2.79822550
117exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79761447
118CENP-A containing nucleosome assembly (GO:0034080)2.79416090
119chromatin remodeling at centromere (GO:0031055)2.78478865
120regulation of DNA damage checkpoint (GO:2000001)2.77630011
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76746508
122ribonucleoprotein complex biogenesis (GO:0022613)2.76562179
123negative regulation of androgen receptor signaling pathway (GO:0060766)2.75706198
124DNA damage response, detection of DNA damage (GO:0042769)2.75007225
125face development (GO:0060324)2.74288329
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73388852
127regulation of spindle checkpoint (GO:0090231)2.70940772
128negative regulation of RNA splicing (GO:0033119)2.70079963
129mRNA export from nucleus (GO:0006406)2.69398035
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.69013480
131paraxial mesoderm development (GO:0048339)2.68873229
132amine catabolic process (GO:0009310)2.68835624
133cellular biogenic amine catabolic process (GO:0042402)2.68835624
134cytochrome complex assembly (GO:0017004)2.67948172
135epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67493009
136preassembly of GPI anchor in ER membrane (GO:0016254)2.67309919
137establishment of apical/basal cell polarity (GO:0035089)2.66852185
138regulation of centrosome cycle (GO:0046605)2.66351979
139DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.66108452
140spliceosomal complex assembly (GO:0000245)2.64761069
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.64654515
142negative regulation of sister chromatid segregation (GO:0033046)2.64654515
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.64654515
144negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64654515
145regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60610508
146regulation of mitotic spindle checkpoint (GO:1903504)2.60610508
147DNA methylation involved in gamete generation (GO:0043046)2.60511149
148detection of light stimulus involved in visual perception (GO:0050908)2.56826744
149detection of light stimulus involved in sensory perception (GO:0050962)2.56826744
150centriole replication (GO:0007099)2.53994934
151transcription elongation from RNA polymerase III promoter (GO:0006385)2.52316554
152termination of RNA polymerase III transcription (GO:0006386)2.52316554
153regulation of MHC class I biosynthetic process (GO:0045343)2.50299275
154nonmotile primary cilium assembly (GO:0035058)2.49708434
155regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.49351813
156negative regulation of reactive oxygen species metabolic process (GO:2000378)2.48840912
157rRNA catabolic process (GO:0016075)2.46347669
158protein polyglutamylation (GO:0018095)2.44682713
159RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.44317617
160tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.44317617
161dopamine transport (GO:0015872)2.44082641
162behavioral response to ethanol (GO:0048149)2.43756443
163signal peptide processing (GO:0006465)2.42859664
164synaptic transmission, cholinergic (GO:0007271)2.41909577
165sulfation (GO:0051923)2.41458505
166regulation of action potential (GO:0098900)2.41298608
167cytoplasmic mRNA processing body assembly (GO:0033962)2.41223806
168cornea development in camera-type eye (GO:0061303)2.41059405
169regulation of gene silencing by RNA (GO:0060966)2.40822996
170regulation of posttranscriptional gene silencing (GO:0060147)2.40822996
171regulation of gene silencing by miRNA (GO:0060964)2.40822996
172DNA catabolic process, exonucleolytic (GO:0000738)2.40611514
173peptidyl-histidine modification (GO:0018202)2.39989753
174tachykinin receptor signaling pathway (GO:0007217)2.39485620
175protein K63-linked deubiquitination (GO:0070536)2.38523279
176tRNA processing (GO:0008033)2.38311257
177reciprocal DNA recombination (GO:0035825)2.37002458
178reciprocal meiotic recombination (GO:0007131)2.37002458
179positive regulation of prostaglandin secretion (GO:0032308)2.33910961
180somite rostral/caudal axis specification (GO:0032525)2.33135075
181indole-containing compound metabolic process (GO:0042430)2.31744210
182multicellular organism reproduction (GO:0032504)2.31401914
183DNA replication-dependent nucleosome assembly (GO:0006335)2.30417723
184DNA replication-dependent nucleosome organization (GO:0034723)2.30417723
185negative regulation of interleukin-1 beta production (GO:0032691)2.30314666
186positive regulation of defense response to virus by host (GO:0002230)2.28492402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57481737
2ZNF274_21170338_ChIP-Seq_K562_Hela4.16360016
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02942947
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.91837902
5VDR_22108803_ChIP-Seq_LS180_Human3.49189493
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38553712
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.33735839
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14749073
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05843575
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92093823
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.89701230
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.84989908
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.84989908
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.84989908
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78834799
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.74083590
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71920170
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.65240710
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.56388787
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.54034242
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47728584
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46077233
23EZH2_22144423_ChIP-Seq_EOC_Human2.41196751
24TP63_19390658_ChIP-ChIP_HaCaT_Human2.40063540
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33987711
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26043036
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24943329
28EWS_26573619_Chip-Seq_HEK293_Human2.24796693
29* FUS_26573619_Chip-Seq_HEK293_Human2.23225351
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.21775881
31* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19513250
32POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14257695
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13995224
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06822999
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05269815
36GBX2_23144817_ChIP-Seq_PC3_Human2.01876421
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.98767761
38VDR_23849224_ChIP-Seq_CD4+_Human1.95977986
39IGF1R_20145208_ChIP-Seq_DFB_Human1.95971817
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.95397106
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95193563
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93823734
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93404720
44MYC_18940864_ChIP-ChIP_HL60_Human1.91820802
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.91681548
46P300_19829295_ChIP-Seq_ESCs_Human1.91284009
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88790848
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.86184091
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85728764
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85313635
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85196777
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82980382
53TTF2_22483619_ChIP-Seq_HELA_Human1.82958184
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82592162
55XRN2_22483619_ChIP-Seq_HELA_Human1.80064430
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79526864
57* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78115222
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75933126
59TAF15_26573619_Chip-Seq_HEK293_Human1.75834241
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72463767
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72402247
62DCP1A_22483619_ChIP-Seq_HELA_Human1.71721302
63ER_23166858_ChIP-Seq_MCF-7_Human1.69753616
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.69578478
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.69152700
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68118705
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.65979995
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65150388
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64772953
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64286145
71TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63664958
72FOXP3_21729870_ChIP-Seq_TREG_Human1.63544014
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.63141439
74GABP_19822575_ChIP-Seq_HepG2_Human1.62023357
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.60273862
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.59140689
77* TP53_22573176_ChIP-Seq_HFKS_Human1.57210050
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55472931
79BCAT_22108803_ChIP-Seq_LS180_Human1.55311089
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55045747
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.53363022
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51876218
83* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.50699652
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.48738826
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46187248
86KDM5A_27292631_Chip-Seq_BREAST_Human1.42395017
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42369930
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.42290544
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41994525
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41526596
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41526596
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41504405
93* ELK1_19687146_ChIP-ChIP_HELA_Human1.40267990
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39373253
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.39020054
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37841260
97SRF_21415370_ChIP-Seq_HL-1_Mouse1.36579260
98CBP_20019798_ChIP-Seq_JUKART_Human1.35200932
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35200932
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35058540
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32792829
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31508983
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30726120
104STAT3_23295773_ChIP-Seq_U87_Human1.29787312
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28751326
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27594897
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24415840
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24066943
109ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21719862
110AR_25329375_ChIP-Seq_VCAP_Human1.20489711
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20376276
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.19964590
113VDR_21846776_ChIP-Seq_THP-1_Human1.19638747
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19127708
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.18823512
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18823512
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17926013
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17762383
119TCF4_22108803_ChIP-Seq_LS180_Human1.16630168
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.15761934
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15081986
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14275985
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14111880
124TCF4_23295773_ChIP-Seq_U87_Human1.13619001
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12773303
126NANOG_19829295_ChIP-Seq_ESCs_Human1.10986948
127SOX2_19829295_ChIP-Seq_ESCs_Human1.10986948
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10390520
129SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09949005
130POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.09792368
131NCOR_22424771_ChIP-Seq_293T_Human1.09603748
132BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08764179
133RUNX2_22187159_ChIP-Seq_PCA_Human1.05894875
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05354130
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03760486
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03486359
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.02764952
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02468997
139KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02410725
140AR_20517297_ChIP-Seq_VCAP_Human1.02255538
141FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02053762
142KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01640551
143GATA3_26560356_Chip-Seq_TH2_Human1.01275298
144IRF1_19129219_ChIP-ChIP_H3396_Human1.01060252
145SMAD4_21741376_ChIP-Seq_EPCs_Human1.00368648
146CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00052749
147SMAD4_21799915_ChIP-Seq_A2780_Human0.99937961
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99717860
149* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99685170
150HOXB7_26014856_ChIP-Seq_BT474_Human0.99654158
151* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99302375
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98770637
153CIITA_25753668_ChIP-Seq_RAJI_Human0.98260484
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.98120051
155HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97473407
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.97275489
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97258594
158ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97076095
159ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96330979
160LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95791696
161CRX_20693478_ChIP-Seq_RETINA_Mouse0.95576227
162PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95556058
163GATA3_21878914_ChIP-Seq_MCF-7_Human0.95098975
164REST_21632747_ChIP-Seq_MESCs_Mouse0.94333977
165SMAD3_21741376_ChIP-Seq_EPCs_Human0.93691066
166TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93214125
167CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92967403
168HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92529985
169* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91367429
170PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91070455
171STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90250177
172RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89831909
173* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.89103748
174TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87044951
175TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86849760
176CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83791013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.46901074
2MP0010094_abnormal_chromosome_stability3.68752326
3MP0008058_abnormal_DNA_repair3.38525719
4MP0003111_abnormal_nucleus_morphology3.34073669
5MP0003195_calcinosis3.20998600
6MP0008877_abnormal_DNA_methylation3.11382498
7MP0005171_absent_coat_pigmentation3.06807358
8MP0003693_abnormal_embryo_hatching3.02752166
9MP0010030_abnormal_orbit_morphology2.81338935
10MP0000569_abnormal_digit_pigmentation2.71698730
11MP0003077_abnormal_cell_cycle2.64897665
12MP0004957_abnormal_blastocyst_morpholog2.56309241
13MP0000372_irregular_coat_pigmentation2.43092546
14MP0003786_premature_aging2.41789469
15MP0008932_abnormal_embryonic_tissue2.31073656
16MP0006292_abnormal_olfactory_placode2.29402387
17MP0001986_abnormal_taste_sensitivity2.25086031
18MP0003890_abnormal_embryonic-extraembry2.24175629
19MP0000427_abnormal_hair_cycle2.13399611
20MP0002009_preneoplasia2.06043988
21MP0005084_abnormal_gallbladder_morpholo2.00946693
22MP0003646_muscle_fatigue1.97990749
23MP0004133_heterotaxia1.97758830
24MP0002736_abnormal_nociception_after1.95808504
25MP0003941_abnormal_skin_development1.93228510
26MP0001968_abnormal_touch/_nociception1.87432211
27MP0008007_abnormal_cellular_replicative1.82927304
28MP0008995_early_reproductive_senescence1.78324213
29MP0001293_anophthalmia1.77866556
30MP0005253_abnormal_eye_physiology1.77814180
31MP0009278_abnormal_bone_marrow1.77746688
32MP0008872_abnormal_physiological_respon1.71886432
33MP0005551_abnormal_eye_electrophysiolog1.69051391
34MP0003718_maternal_effect1.68159912
35MP0000566_synostosis1.63187540
36MP0003136_yellow_coat_color1.60498935
37MP0004142_abnormal_muscle_tone1.60235734
38MP0005174_abnormal_tail_pigmentation1.57818370
39MP0003119_abnormal_digestive_system1.52598880
40MP0000647_abnormal_sebaceous_gland1.49284657
41MP0002249_abnormal_larynx_morphology1.45758556
42MP0000383_abnormal_hair_follicle1.45364005
43MP0003787_abnormal_imprinting1.43095503
44MP0000015_abnormal_ear_pigmentation1.42689395
45MP0002085_abnormal_embryonic_tissue1.40872172
46MP0006072_abnormal_retinal_apoptosis1.39603040
47MP0004885_abnormal_endolymph1.37783635
48MP0002254_reproductive_system_inflammat1.37769876
49MP0002653_abnormal_ependyma_morphology1.37750714
50MP0000350_abnormal_cell_proliferation1.37294215
51MP0001188_hyperpigmentation1.36854973
52MP0002138_abnormal_hepatobiliary_system1.36750695
53MP0001672_abnormal_embryogenesis/_devel1.33190715
54MP0005380_embryogenesis_phenotype1.33190715
55MP0002638_abnormal_pupillary_reflex1.31817512
56MP0003567_abnormal_fetal_cardiomyocyte1.31664243
57MP0006035_abnormal_mitochondrial_morpho1.30712528
58MP0009745_abnormal_behavioral_response1.30391964
59MP0009046_muscle_twitch1.28680367
60MP0000631_abnormal_neuroendocrine_gland1.27861278
61MP0001529_abnormal_vocalization1.27058510
62MP0002837_dystrophic_cardiac_calcinosis1.26452529
63MP0002938_white_spotting1.26029740
64MP0001697_abnormal_embryo_size1.24327048
65MP0003121_genomic_imprinting1.24305562
66MP0003011_delayed_dark_adaptation1.24280189
67MP0005379_endocrine/exocrine_gland_phen1.23367599
68MP0006276_abnormal_autonomic_nervous1.22498930
69MP0000490_abnormal_crypts_of1.22442128
70MP0003123_paternal_imprinting1.20979212
71MP0001485_abnormal_pinna_reflex1.19511866
72MP0003755_abnormal_palate_morphology1.18172280
73MP0001286_abnormal_eye_development1.18160535
74MP0002084_abnormal_developmental_patter1.17647966
75MP0005075_abnormal_melanosome_morpholog1.17104926
76MP0002210_abnormal_sex_determination1.16615785
77MP0003315_abnormal_perineum_morphology1.13249947
78MP0008961_abnormal_basal_metabolism1.12724248
79MP0002086_abnormal_extraembryonic_tissu1.11019327
80MP0001730_embryonic_growth_arrest1.10360216
81MP0004197_abnormal_fetal_growth/weight/1.10281007
82MP0002163_abnormal_gland_morphology1.09241101
83MP0002396_abnormal_hematopoietic_system1.08070448
84MP0005646_abnormal_pituitary_gland1.07375047
85MP0000762_abnormal_tongue_morphology1.07171890
86MP0002111_abnormal_tail_morphology1.06899824
87MP0002277_abnormal_respiratory_mucosa1.06664804
88MP0002095_abnormal_skin_pigmentation1.06621518
89MP0001145_abnormal_male_reproductive1.06421552
90MP0004043_abnormal_pH_regulation1.04626550
91MP0003984_embryonic_growth_retardation1.04201295
92MP0002751_abnormal_autonomic_nervous1.03003013
93MP0001984_abnormal_olfaction1.02951423
94MP0005671_abnormal_response_to1.02472702
95MP0000313_abnormal_cell_death1.02184247
96MP0009764_decreased_sensitivity_to1.01213726
97MP0001501_abnormal_sleep_pattern1.00882656
98MP0000049_abnormal_middle_ear1.00220114
99MP0002088_abnormal_embryonic_growth/wei0.99544775
100MP0005397_hematopoietic_system_phenotyp0.98653007
101MP0001545_abnormal_hematopoietic_system0.98653007
102MP0002160_abnormal_reproductive_system0.98416351
103MP0000432_abnormal_head_morphology0.98113064
104MP0005195_abnormal_posterior_eye0.97908539
105MP0001486_abnormal_startle_reflex0.97766471
106MP0001873_stomach_inflammation0.96554834
107MP0001186_pigmentation_phenotype0.96087223
108MP0003935_abnormal_craniofacial_develop0.95574337
109MP0002132_abnormal_respiratory_system0.95484725
110MP0004233_abnormal_muscle_weight0.95244568
111MP0002272_abnormal_nervous_system0.94620687
112MP0002116_abnormal_craniofacial_bone0.94012672
113MP0003937_abnormal_limbs/digits/tail_de0.93741074
114MP0008789_abnormal_olfactory_epithelium0.93632897
115MP0005389_reproductive_system_phenotype0.93063188
116MP0002114_abnormal_axial_skeleton0.92560631
117MP0001119_abnormal_female_reproductive0.92234847
118MP0002234_abnormal_pharynx_morphology0.91638777
119MP0003385_abnormal_body_wall0.91182862
120MP0000653_abnormal_sex_gland0.90429327
121MP0003878_abnormal_ear_physiology0.89899372
122MP0005377_hearing/vestibular/ear_phenot0.89899372
123MP0002876_abnormal_thyroid_physiology0.89335651
124MP0005367_renal/urinary_system_phenotyp0.88071988
125MP0000516_abnormal_urinary_system0.88071988
126MP0002080_prenatal_lethality0.87723211
127MP0004924_abnormal_behavior0.87440562
128MP0005386_behavior/neurological_phenoty0.87440562
129MP0002019_abnormal_tumor_incidence0.86884081
130MP0001324_abnormal_eye_pigmentation0.85350509
131MP0002075_abnormal_coat/hair_pigmentati0.83230801
132MP0000470_abnormal_stomach_morphology0.82404506
133MP0004742_abnormal_vestibular_system0.81943413
134MP0005310_abnormal_salivary_gland0.81735572
135MP0004147_increased_porphyrin_level0.81401498
136MP0003861_abnormal_nervous_system0.80729620
137MP0002932_abnormal_joint_morphology0.80197282
138MP0002282_abnormal_trachea_morphology0.80163574
139MP0001929_abnormal_gametogenesis0.79854691
140MP0003936_abnormal_reproductive_system0.79544703
141MP0001800_abnormal_humoral_immune0.79063703
142MP0000462_abnormal_digestive_system0.78813185
143MP0003938_abnormal_ear_development0.78386273
144MP0008875_abnormal_xenobiotic_pharmacok0.78023749
145MP0003252_abnormal_bile_duct0.77142376
146MP0003186_abnormal_redox_activity0.76668097
147MP0002928_abnormal_bile_duct0.75777158
148MP0005391_vision/eye_phenotype0.75325631
149MP0005645_abnormal_hypothalamus_physiol0.74668452
150MP0000685_abnormal_immune_system0.73838828
151MP0002693_abnormal_pancreas_physiology0.73808809
152MP0002102_abnormal_ear_morphology0.72508989
153MP0002733_abnormal_thermal_nociception0.71058748
154MP0001919_abnormal_reproductive_system0.69761681
155MP0005076_abnormal_cell_differentiation0.68988294
156MP0000703_abnormal_thymus_morphology0.68305504
157MP0009333_abnormal_splenocyte_physiolog0.68284209
158MP0001340_abnormal_eyelid_morphology0.67194809
159MP0002697_abnormal_eye_size0.67048409

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.16884257
2Pancreatic cysts (HP:0001737)4.05977777
3Chromsome breakage (HP:0040012)3.91983545
4Abnormality of midbrain morphology (HP:0002418)3.86496213
5Molar tooth sign on MRI (HP:0002419)3.86496213
6Patellar aplasia (HP:0006443)3.70734740
7Absent radius (HP:0003974)3.67844799
8Rib fusion (HP:0000902)3.65123599
9Breast hypoplasia (HP:0003187)3.64790125
10Rectovaginal fistula (HP:0000143)3.63556668
11Rectal fistula (HP:0100590)3.63556668
12Pancreatic fibrosis (HP:0100732)3.59945648
13True hermaphroditism (HP:0010459)3.50283834
14Aplasia/Hypoplasia of the patella (HP:0006498)3.48241236
15Aplasia involving forearm bones (HP:0009822)3.45966783
16Absent forearm bone (HP:0003953)3.45966783
17Pendular nystagmus (HP:0012043)3.40882397
18Intestinal fistula (HP:0100819)3.37521860
19Abnormality of the ileum (HP:0001549)3.29545069
20Facial hemangioma (HP:0000329)3.28528494
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.25895754
22Concave nail (HP:0001598)3.18795295
23Birth length less than 3rd percentile (HP:0003561)3.16047201
24Nephronophthisis (HP:0000090)3.14252899
25Congenital stationary night blindness (HP:0007642)3.13732622
26Abolished electroretinogram (ERG) (HP:0000550)3.04971660
27Intestinal atresia (HP:0011100)3.04430089
28Acute lymphatic leukemia (HP:0006721)2.93672656
29Increased IgM level (HP:0003496)2.93518201
30Abnormality of the labia minora (HP:0012880)2.90847034
31Vaginal fistula (HP:0004320)2.85513837
32Abnormality of the renal medulla (HP:0100957)2.82043734
33Absent thumb (HP:0009777)2.80873388
34Meckel diverticulum (HP:0002245)2.80196836
35Premature graying of hair (HP:0002216)2.74150914
36Duplicated collecting system (HP:0000081)2.68863374
37Volvulus (HP:0002580)2.65473281
38Abnormality of the renal cortex (HP:0011035)2.62875733
39Attenuation of retinal blood vessels (HP:0007843)2.62771688
40Aplasia/hypoplasia of the humerus (HP:0006507)2.61652463
41Type II lissencephaly (HP:0007260)2.59733035
42Nephroblastoma (Wilms tumor) (HP:0002667)2.59047552
43Supernumerary spleens (HP:0009799)2.56650075
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.54272022
45Inability to walk (HP:0002540)2.53497064
46Embryonal renal neoplasm (HP:0011794)2.52849989
47Genetic anticipation (HP:0003743)2.50972971
48Hypochromic microcytic anemia (HP:0004840)2.49523258
49Abnormality of the renal collecting system (HP:0004742)2.49213596
50Congenital, generalized hypertrichosis (HP:0004540)2.49040809
51Abnormality of the preputium (HP:0100587)2.47993557
52Tubular atrophy (HP:0000092)2.46854860
53Medulloblastoma (HP:0002885)2.45824618
54Hyperventilation (HP:0002883)2.41176989
55Acute necrotizing encephalopathy (HP:0006965)2.37722956
56Chronic hepatic failure (HP:0100626)2.37495229
57Abnormality of male internal genitalia (HP:0000022)2.37214957
58Pustule (HP:0200039)2.36992971
59Poikiloderma (HP:0001029)2.35946514
60Abnormal drinking behavior (HP:0030082)2.34242025
61Polydipsia (HP:0001959)2.34242025
62Oligodactyly (hands) (HP:0001180)2.34217134
63Abnormality of chromosome stability (HP:0003220)2.33593861
64Abnormal number of incisors (HP:0011064)2.31833845
65Capillary hemangiomas (HP:0005306)2.28798928
66Medial flaring of the eyebrow (HP:0010747)2.28691433
67Acute encephalopathy (HP:0006846)2.28587296
68Short thumb (HP:0009778)2.27800406
69Septo-optic dysplasia (HP:0100842)2.25648160
70Lissencephaly (HP:0001339)2.25402727
71Muscle fiber atrophy (HP:0100295)2.25294500
72Aplasia of the musculature (HP:0100854)2.24005662
73Hypoplasia of the radius (HP:0002984)2.21998643
74Type 2 muscle fiber atrophy (HP:0003554)2.21638113
75Abnormality of alanine metabolism (HP:0010916)2.21419244
76Hyperalaninemia (HP:0003348)2.21419244
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21419244
78Short humerus (HP:0005792)2.21382559
79Anencephaly (HP:0002323)2.20956677
80Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19903069
81Selective tooth agenesis (HP:0001592)2.18905115
82Reticulocytopenia (HP:0001896)2.18841910
83Progressive inability to walk (HP:0002505)2.18376382
84Cleft eyelid (HP:0000625)2.18037298
85Progressive cerebellar ataxia (HP:0002073)2.16471060
86Ectopic kidney (HP:0000086)2.15992435
87Tongue fasciculations (HP:0001308)2.15762834
88Increased CSF lactate (HP:0002490)2.13456482
89Aplasia/Hypoplasia involving the musculature (HP:0001460)2.12960670
90Neoplasm of the adrenal cortex (HP:0100641)2.12412825
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11150633
92Mitochondrial inheritance (HP:0001427)2.11035783
93Squamous cell carcinoma (HP:0002860)2.09182735
94Methylmalonic acidemia (HP:0002912)2.08293215
95Glioma (HP:0009733)2.07510227
96Cerebral hypomyelination (HP:0006808)2.06988379
97Gaze-evoked nystagmus (HP:0000640)2.06689003
98Sclerocornea (HP:0000647)2.05654256
99Median cleft lip (HP:0000161)2.03788419
100Progressive macrocephaly (HP:0004481)2.03724039
101Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03246158
102Decreased central vision (HP:0007663)2.02360644
103Abnormal rod and cone electroretinograms (HP:0008323)2.02216025
104Basal cell carcinoma (HP:0002671)1.99811632
105Gastrointestinal atresia (HP:0002589)1.99747264
106Stomatitis (HP:0010280)1.99438035
107Cystic liver disease (HP:0006706)1.99414534
108Optic nerve hypoplasia (HP:0000609)1.98602691
109Colon cancer (HP:0003003)1.98286834
110Impulsivity (HP:0100710)1.98118924
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.97599823
112Hyperglycinemia (HP:0002154)1.97485834
113Increased number of teeth (HP:0011069)1.97223935
114Protruding tongue (HP:0010808)1.96570020
115Aplasia/Hypoplasia of the spleen (HP:0010451)1.96361963
116Alacrima (HP:0000522)1.95605994
117Bifid uvula (HP:0000193)1.95497956
118Chorioretinal atrophy (HP:0000533)1.95190341
119Abnormality of the pons (HP:0007361)1.95042231
120Decreased lacrimation (HP:0000633)1.93832368
121Annular pancreas (HP:0001734)1.93305195
122Abnormal hemoglobin (HP:0011902)1.93287461
123Abnormality of the aortic arch (HP:0012303)1.92131384
124Anteriorly placed anus (HP:0001545)1.91739679
125Polyuria (HP:0000103)1.91691162
126Alopecia of scalp (HP:0002293)1.91657960
127Abnormality of DNA repair (HP:0003254)1.91525100
128Triphalangeal thumb (HP:0001199)1.91510811
129Abnormality of macular pigmentation (HP:0008002)1.90737431
130Supernumerary bones of the axial skeleton (HP:0009144)1.90626321
131Clumsiness (HP:0002312)1.90418058
132Hypoplastic iliac wings (HP:0002866)1.88584770
133Abdominal situs inversus (HP:0003363)1.88485250
134Abnormality of abdominal situs (HP:0011620)1.88485250
135Bilateral microphthalmos (HP:0007633)1.88083824
136Coronal craniosynostosis (HP:0004440)1.87900611
137Broad-based gait (HP:0002136)1.87467894
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.86640661
139Dandy-Walker malformation (HP:0001305)1.85746589
140Methylmalonic aciduria (HP:0012120)1.84843000
141Myelodysplasia (HP:0002863)1.84369494
142Exertional dyspnea (HP:0002875)1.83515822
143Abnormal mitochondria in muscle tissue (HP:0008316)1.83506049
144Prostate neoplasm (HP:0100787)1.83410034
145Keratoconus (HP:0000563)1.81837995
146Increased corneal curvature (HP:0100692)1.81837995
147Hypoplasia of the pons (HP:0012110)1.80875271
148Muscle fibrillation (HP:0010546)1.80669175
149Abnormality of the septum pellucidum (HP:0007375)1.80452287
150Supernumerary ribs (HP:0005815)1.79725776
151Hypothermia (HP:0002045)1.79554281
152Shawl scrotum (HP:0000049)1.78956865
153Small intestinal stenosis (HP:0012848)1.78768722
154Duodenal stenosis (HP:0100867)1.78768722
155Asplenia (HP:0001746)1.78703076
156Carpal bone hypoplasia (HP:0001498)1.78612992
157Optic disc pallor (HP:0000543)1.78540864
158Neoplasm of the oral cavity (HP:0100649)1.77471235
159Vertebral fusion (HP:0002948)1.76022186
160Stomach cancer (HP:0012126)1.75730422
161Hemivertebrae (HP:0002937)1.75447673
162Bony spicule pigmentary retinopathy (HP:0007737)1.74612619
163Male pseudohermaphroditism (HP:0000037)1.73714644
164Small hand (HP:0200055)1.73477603
165Clubbing of toes (HP:0100760)1.73307980
166Abnormal number of erythroid precursors (HP:0012131)1.72845382
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.72554087
168Absent/shortened dynein arms (HP:0200106)1.72554087
169Congenital hepatic fibrosis (HP:0002612)1.72225360
170Abnormality of the nasal septum (HP:0000419)1.72180860
171Sloping forehead (HP:0000340)1.71580971
172Pachygyria (HP:0001302)1.71434187
173Rhabdomyosarcoma (HP:0002859)1.71420817
174Abnormal lung lobation (HP:0002101)1.71286647
175Rough bone trabeculation (HP:0100670)1.70749637
1763-Methylglutaconic aciduria (HP:0003535)1.69303263
177Fair hair (HP:0002286)1.69276988
178Cerebellar dysplasia (HP:0007033)1.68854985
179Furrowed tongue (HP:0000221)1.67477166
180Anophthalmia (HP:0000528)1.66929379
181Broad alveolar ridges (HP:0000187)1.66246165
182Abnormal respiratory epithelium morphology (HP:0012253)1.65274314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.75195435
2MAP3K64.03567740
3INSRR3.16454177
4PLK43.16277071
5MAPK152.97155337
6ICK2.93307386
7BUB12.76891533
8BMPR1B2.76780722
9DDR22.58218331
10ADRBK22.49616946
11SRPK12.46777894
12CDK192.36498189
13PINK12.36202675
14IRAK32.26861909
15OXSR12.26759945
16YES12.26701919
17WNK42.26416786
18TAOK32.20767033
19ZAK2.20528661
20AKT32.15274832
21CDC72.11839015
22MKNK22.10542177
23MAP4K22.08390461
24MAP3K112.01690639
25CDK71.99201145
26TNIK1.93682320
27WEE11.93655862
28WNK31.93454735
29GRK11.93042611
30CHEK21.86361304
31PRPF4B1.74759023
32PLK11.73811019
33PIM21.66855579
34MKNK11.65261484
35FGR1.63410552
36TTK1.63237876
37CASK1.60253300
38EIF2AK11.56745174
39TRIM281.54836240
40MATK1.51595185
41ATR1.46477971
42TAOK21.43570639
43CDK121.39857363
44MAP3K41.39122760
45UHMK11.35905979
46PRKD21.34359334
47EPHA21.34178641
48VRK21.33705337
49IRAK41.28154350
50STK391.26061454
51DYRK31.23229648
52STK38L1.21554471
53VRK11.20659516
54TAF11.14644416
55TLK11.14316682
56LATS21.12415480
57TGFBR11.10692443
58CSK1.08338229
59PIM11.07555804
60DAPK11.07334370
61MST41.02499389
62CDK61.02164731
63STK161.02035644
64PLK30.98428666
65TEC0.98235525
66CDK80.97104154
67CAMKK20.95305870
68DYRK20.95129232
69BRD40.93582245
70AURKB0.93571417
71PLK20.93438870
72CHEK10.91295194
73MAPK130.90313027
74ADRBK10.87909120
75TYRO30.87295831
76AURKA0.86424034
77TIE10.86070614
78ATM0.84467469
79CDC42BPA0.83209131
80LATS10.81155142
81CDK20.76733962
82IRAK20.76322810
83NLK0.75817923
84BRSK20.75744397
85PRKCE0.72501845
86PAK30.72152257
87CSNK2A10.71266589
88CSNK1G20.70185018
89DYRK1B0.70106975
90TSSK60.69551311
91PRKCG0.69192674
92MARK10.68909871
93STK40.68721049
94NEK20.68405365
95PNCK0.66157829
96PBK0.66136988
97CHUK0.65258487
98RPS6KL10.63701525
99RPS6KC10.63701525
100CDK10.62409218
101GRK70.62042764
102SIK30.61557799
103CDK30.61262138
104WNK10.61217925
105CLK10.61163248
106ERBB30.60378347
107DAPK20.58426002
108TRPM70.57350641
109IRAK10.57288385
110STK110.56976325
111IKBKE0.56920498
112BMX0.56890031
113EIF2AK20.56232154
114CDK40.55814825
115CSNK1G30.55560521
116MARK30.53637139
117PRKCQ0.53379432
118CSNK2A20.53353577
119SIK20.52445300
120BRSK10.52298928
121EIF2AK30.51703394
122RPS6KA60.50049554
123PRKCI0.49330747
124PIK3CG0.48812844
125ACVR1B0.48291385
126MAP2K60.47605041
127STK30.47586234
128FER0.47194704
129RPS6KB20.46800098
130TNK20.46163155
131FGFR20.43906585
132MAP2K70.42925724
133FES0.42721888
134CSNK1A1L0.42315002
135TXK0.40588140
136CAMK1D0.38911532
137NME10.38772883
138PASK0.38563200
139MAPK140.38516426
140CSNK1G10.38512513
141BMPR20.37001904
142LYN0.36879487
143RPS6KA40.36233532
144ITK0.35880791
145ALK0.35794473
146MAPK40.35760845
147BCR0.35211902
148PKN10.34408570
149PRKDC0.33954359
150CAMK2B0.33420342
151CSNK1A10.32600162
152GSK3B0.32111122
153KIT0.31265285
154NUAK10.31231851
155RPS6KA50.30214120
156PRKG10.29578569
157CSNK1E0.28852547
158IKBKB0.28156992
159MELK0.27106724

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69413979
2Mismatch repair_Homo sapiens_hsa034304.65661835
3Base excision repair_Homo sapiens_hsa034103.83126825
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.29219487
5Homologous recombination_Homo sapiens_hsa034403.22985804
6Fanconi anemia pathway_Homo sapiens_hsa034603.20632373
7Spliceosome_Homo sapiens_hsa030403.12189168
8RNA polymerase_Homo sapiens_hsa030202.97070866
9Nucleotide excision repair_Homo sapiens_hsa034202.91668849
10Ribosome_Homo sapiens_hsa030102.54635858
11Cell cycle_Homo sapiens_hsa041102.48630339
12RNA transport_Homo sapiens_hsa030132.47610102
13Selenocompound metabolism_Homo sapiens_hsa004502.42447628
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22362933
15mRNA surveillance pathway_Homo sapiens_hsa030152.09576522
16Basal transcription factors_Homo sapiens_hsa030222.09485535
17Proteasome_Homo sapiens_hsa030502.06404302
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01751224
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85592813
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84073923
21Pyrimidine metabolism_Homo sapiens_hsa002401.80281290
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72024887
23Nitrogen metabolism_Homo sapiens_hsa009101.68513178
24Non-homologous end-joining_Homo sapiens_hsa034501.68253710
25Linoleic acid metabolism_Homo sapiens_hsa005911.67605466
26p53 signaling pathway_Homo sapiens_hsa041151.66204655
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.64624187
28RNA degradation_Homo sapiens_hsa030181.61309974
29Butanoate metabolism_Homo sapiens_hsa006501.59752979
30Ether lipid metabolism_Homo sapiens_hsa005651.49693597
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34316946
32One carbon pool by folate_Homo sapiens_hsa006701.31916961
33Olfactory transduction_Homo sapiens_hsa047401.31107287
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28508782
35Notch signaling pathway_Homo sapiens_hsa043301.27085728
36Tryptophan metabolism_Homo sapiens_hsa003801.25624681
37Fatty acid biosynthesis_Homo sapiens_hsa000611.23964641
38Hedgehog signaling pathway_Homo sapiens_hsa043401.21300509
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13149239
40Epstein-Barr virus infection_Homo sapiens_hsa051691.13069673
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07551486
42Nicotine addiction_Homo sapiens_hsa050331.07268341
43Hippo signaling pathway_Homo sapiens_hsa043901.07238676
44Caffeine metabolism_Homo sapiens_hsa002321.06311223
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05401034
46Basal cell carcinoma_Homo sapiens_hsa052171.04388283
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02410729
48Collecting duct acid secretion_Homo sapiens_hsa049660.95151819
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95115860
50Purine metabolism_Homo sapiens_hsa002300.94526315
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94419607
52Primary immunodeficiency_Homo sapiens_hsa053400.94323756
53Alzheimers disease_Homo sapiens_hsa050100.93251077
54Propanoate metabolism_Homo sapiens_hsa006400.93080265
55Regulation of autophagy_Homo sapiens_hsa041400.92687017
56TGF-beta signaling pathway_Homo sapiens_hsa043500.92179340
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.92134001
58Oocyte meiosis_Homo sapiens_hsa041140.91981202
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88928881
60Peroxisome_Homo sapiens_hsa041460.88627434
61Wnt signaling pathway_Homo sapiens_hsa043100.88278098
62Type I diabetes mellitus_Homo sapiens_hsa049400.84761785
63Taste transduction_Homo sapiens_hsa047420.84493743
64Herpes simplex infection_Homo sapiens_hsa051680.84100636
65MicroRNAs in cancer_Homo sapiens_hsa052060.78519881
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75457432
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75118410
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74186551
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73289476
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.72341435
71Huntingtons disease_Homo sapiens_hsa050160.71956548
72Viral carcinogenesis_Homo sapiens_hsa052030.71391576
73Circadian rhythm_Homo sapiens_hsa047100.69321700
74Adherens junction_Homo sapiens_hsa045200.69185243
75HTLV-I infection_Homo sapiens_hsa051660.67491125
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66665484
77Cardiac muscle contraction_Homo sapiens_hsa042600.65598387
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65044542
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64368868
80Morphine addiction_Homo sapiens_hsa050320.62919815
81Shigellosis_Homo sapiens_hsa051310.60632314
82Rheumatoid arthritis_Homo sapiens_hsa053230.60600331
83Colorectal cancer_Homo sapiens_hsa052100.60455827
84Steroid biosynthesis_Homo sapiens_hsa001000.60040519
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58372486
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.56360157
87Systemic lupus erythematosus_Homo sapiens_hsa053220.54367112
88Arginine and proline metabolism_Homo sapiens_hsa003300.54019957
89Arachidonic acid metabolism_Homo sapiens_hsa005900.53081018
90Phototransduction_Homo sapiens_hsa047440.50682152
91Ovarian steroidogenesis_Homo sapiens_hsa049130.49891495
92Serotonergic synapse_Homo sapiens_hsa047260.48571125
93Metabolic pathways_Homo sapiens_hsa011000.47421064
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46202489
95Vitamin B6 metabolism_Homo sapiens_hsa007500.46014620
96Small cell lung cancer_Homo sapiens_hsa052220.42447282
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.42092656
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41611227
99Measles_Homo sapiens_hsa051620.41253407
100Prostate cancer_Homo sapiens_hsa052150.40767928
101Glutathione metabolism_Homo sapiens_hsa004800.39756833
102Pathways in cancer_Homo sapiens_hsa052000.39184029
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38740573
104Bladder cancer_Homo sapiens_hsa052190.37684173
105Hepatitis B_Homo sapiens_hsa051610.36965924
106Melanoma_Homo sapiens_hsa052180.36805315
107Parkinsons disease_Homo sapiens_hsa050120.36588117
108Retinol metabolism_Homo sapiens_hsa008300.36219136
109Chemical carcinogenesis_Homo sapiens_hsa052040.35977090
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35656922
111Folate biosynthesis_Homo sapiens_hsa007900.35475061
112Viral myocarditis_Homo sapiens_hsa054160.34744274
113Autoimmune thyroid disease_Homo sapiens_hsa053200.33321485
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32724237
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.32688993
116Graft-versus-host disease_Homo sapiens_hsa053320.32352094
117Acute myeloid leukemia_Homo sapiens_hsa052210.31603121
118mTOR signaling pathway_Homo sapiens_hsa041500.31158760
119Oxidative phosphorylation_Homo sapiens_hsa001900.30650057
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29924003
121ErbB signaling pathway_Homo sapiens_hsa040120.27918298
122Allograft rejection_Homo sapiens_hsa053300.27720474
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27586719
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27565697
125Chronic myeloid leukemia_Homo sapiens_hsa052200.27075923
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26747625
127Lysine degradation_Homo sapiens_hsa003100.26735472
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26351371
129Tight junction_Homo sapiens_hsa045300.25866677
130Legionellosis_Homo sapiens_hsa051340.25363946
131Dorso-ventral axis formation_Homo sapiens_hsa043200.24676740
132Sulfur relay system_Homo sapiens_hsa041220.24371224
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.24131815
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23441128
135Apoptosis_Homo sapiens_hsa042100.22618876
136Choline metabolism in cancer_Homo sapiens_hsa052310.22592513
137FoxO signaling pathway_Homo sapiens_hsa040680.18796151
138MAPK signaling pathway_Homo sapiens_hsa040100.18688568
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16803260
140Pancreatic cancer_Homo sapiens_hsa052120.16733874
141Protein export_Homo sapiens_hsa030600.16400329
142Thyroid cancer_Homo sapiens_hsa052160.15737842
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15107098
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13148718
145Alcoholism_Homo sapiens_hsa050340.13049866
146Asthma_Homo sapiens_hsa053100.12831049
147Hematopoietic cell lineage_Homo sapiens_hsa046400.12373166

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