GMEB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.12198837
2regulation of gamma-delta T cell differentiation (GO:0045586)4.66795102
3dosage compensation (GO:0007549)4.58934013
4negative regulation of erythrocyte differentiation (GO:0045647)4.54776145
5regulation of gamma-delta T cell activation (GO:0046643)4.36761548
6positive regulation of histone deacetylation (GO:0031065)3.91574243
7response to peptidoglycan (GO:0032494)3.83674754
8positive regulation by symbiont of host defense response (GO:0052509)3.75386233
9modulation by symbiont of host defense response (GO:0052031)3.75386233
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.75386233
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.75386233
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.75386233
13modulation by symbiont of host immune response (GO:0052553)3.75386233
14positive thymic T cell selection (GO:0045059)3.63946485
15negative regulation of cell killing (GO:0031342)3.63270168
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63270168
17regulation of interleukin-12 biosynthetic process (GO:0045075)3.60996922
18activation of Rac GTPase activity (GO:0032863)3.55278052
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.54568262
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.54568262
21nuclear pore complex assembly (GO:0051292)3.40862995
22regulation of oxidative stress-induced neuron death (GO:1903203)3.36152585
23positive regulation of Cdc42 GTPase activity (GO:0043089)3.35238607
24antigen processing and presentation of endogenous antigen (GO:0019883)3.34467630
25positive regulation of B cell differentiation (GO:0045579)3.29573673
26antigen processing and presentation via MHC class Ib (GO:0002475)3.25202325
27negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.23746665
28modulation by symbiont of host cellular process (GO:0044068)3.21736075
29mannose metabolic process (GO:0006013)3.14661955
30negative thymic T cell selection (GO:0045060)3.10255042
31modulation by virus of host process (GO:0019054)3.08383466
32detection of bacterium (GO:0016045)3.03836370
33detection of other organism (GO:0098543)3.02967943
34negative T cell selection (GO:0043383)3.02748297
35nuclear pore organization (GO:0006999)3.02388063
36positive regulation of protein import into nucleus, translocation (GO:0033160)3.01753649
37histone mRNA catabolic process (GO:0071044)2.97218424
38macrophage activation involved in immune response (GO:0002281)2.93505293
39apoptotic process involved in morphogenesis (GO:0060561)2.92204932
40protein localization to endosome (GO:0036010)2.91961197
41tolerance induction (GO:0002507)2.88619183
42germinal center formation (GO:0002467)2.87494321
43regulation of B cell differentiation (GO:0045577)2.85184984
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84780058
45regulation of NFAT protein import into nucleus (GO:0051532)2.83570147
46lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80707744
47natural killer cell differentiation (GO:0001779)2.80296183
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78757363
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77960580
50activation of MAPKKK activity (GO:0000185)2.77889068
51positive regulation of protein deacetylation (GO:0090312)2.76305737
52heterochromatin organization (GO:0070828)2.76300793
53thymic T cell selection (GO:0045061)2.76237651
54pre-miRNA processing (GO:0031054)2.75374335
55regulation of histone H3-K27 methylation (GO:0061085)2.75059417
56cellular response to virus (GO:0098586)2.75015900
57positive T cell selection (GO:0043368)2.74215307
58Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73940872
59embryonic process involved in female pregnancy (GO:0060136)2.69882788
60JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.68825234
61regulation of T-helper 2 cell differentiation (GO:0045628)2.67693040
62myeloid dendritic cell differentiation (GO:0043011)2.66810379
63mitotic chromosome condensation (GO:0007076)2.66312685
64mRNA stabilization (GO:0048255)2.63679399
65RNA stabilization (GO:0043489)2.63679399
66regulation of necroptotic process (GO:0060544)2.62440641
67T cell selection (GO:0045058)2.61103488
68negative regulation of histone methylation (GO:0031061)2.58725638
69negative regulation of necroptotic process (GO:0060546)2.57897096
70response to interleukin-15 (GO:0070672)2.57887796
71leukocyte aggregation (GO:0070486)2.57524371
72intracellular estrogen receptor signaling pathway (GO:0030520)2.57519137
73cell-substrate adherens junction assembly (GO:0007045)2.57077940
74focal adhesion assembly (GO:0048041)2.57077940
75pore complex assembly (GO:0046931)2.55802840
76neutrophil activation involved in immune response (GO:0002283)2.55401424
77regulation of sister chromatid cohesion (GO:0007063)2.55272672
78negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55005191
79regulation of RNA export from nucleus (GO:0046831)2.53587820
80regulation of T cell tolerance induction (GO:0002664)2.52165040
81response to muramyl dipeptide (GO:0032495)2.51057812
82regulation of leukocyte degranulation (GO:0043300)2.50575339
83negative regulation of granulocyte differentiation (GO:0030853)2.50044879
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.49903704
85positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.49875380
86cellular response to type I interferon (GO:0071357)2.49759138
87type I interferon signaling pathway (GO:0060337)2.49759138
883-UTR-mediated mRNA stabilization (GO:0070935)2.49655010
89folic acid-containing compound biosynthetic process (GO:0009396)2.49296684
90positive regulation of isotype switching (GO:0045830)2.49268749
91regulation of chromatin binding (GO:0035561)2.48951546
92adherens junction assembly (GO:0034333)2.47595742
93response to type I interferon (GO:0034340)2.47567364
94interferon-gamma production (GO:0032609)2.47528519
95positive regulation of interleukin-2 production (GO:0032743)2.45823427
96histone H3-K9 demethylation (GO:0033169)2.45656443
97mitotic nuclear envelope disassembly (GO:0007077)2.45551310
98negative regulation of viral release from host cell (GO:1902187)2.45522407
99regulation of interferon-beta biosynthetic process (GO:0045357)2.44914965
100pinocytosis (GO:0006907)2.44901167
101protein localization to kinetochore (GO:0034501)2.43852505
102negative regulation of fatty acid transport (GO:2000192)2.42916434
103detection of external biotic stimulus (GO:0098581)2.41982702
104membrane disassembly (GO:0030397)2.41120930
105nuclear envelope disassembly (GO:0051081)2.41120930
106regulation of type I interferon-mediated signaling pathway (GO:0060338)2.40939309
107positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.40865397
108signal complex assembly (GO:0007172)2.40202451
109T cell costimulation (GO:0031295)2.39383649
110response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.39288834
111response to host (GO:0075136)2.39288834
112response to host defenses (GO:0052200)2.39288834
113regulation of mammary gland epithelial cell proliferation (GO:0033599)2.39029078
114NIK/NF-kappaB signaling (GO:0038061)2.37984903
115regulation of mast cell degranulation (GO:0043304)2.35372270
116corticosteroid receptor signaling pathway (GO:0031958)2.34856062
117sister chromatid segregation (GO:0000819)2.34052957
118histone lysine demethylation (GO:0070076)2.33509191
119negative regulation of RNA splicing (GO:0033119)2.33420305
120monoubiquitinated protein deubiquitination (GO:0035520)2.32889890
121positive regulation of keratinocyte differentiation (GO:0045618)2.32767762
122positive regulation of T cell apoptotic process (GO:0070234)2.32430422
123stress fiber assembly (GO:0043149)2.32186076
124glucocorticoid receptor signaling pathway (GO:0042921)2.31257634
125lymphocyte costimulation (GO:0031294)2.30851045
126myeloid dendritic cell activation (GO:0001773)2.30732152
127snRNA processing (GO:0016180)2.30489826
128response to host immune response (GO:0052572)2.30012478
129response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.30012478
130regulation of response to interferon-gamma (GO:0060330)2.29942535
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.29934186
132positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.29124079
133snRNA metabolic process (GO:0016073)2.28807934
134Golgi transport vesicle coating (GO:0048200)2.28550160
135COPI coating of Golgi vesicle (GO:0048205)2.28550160
136negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.28528811
137histone demethylation (GO:0016577)2.28456775
138DNA unwinding involved in DNA replication (GO:0006268)2.28286957
139immunoglobulin mediated immune response (GO:0016064)2.28274725
140cytoplasmic mRNA processing body assembly (GO:0033962)2.28143581
141maternal placenta development (GO:0001893)2.27952362
142negative regulation by host of viral transcription (GO:0043922)2.27392039
143regulation of protein import into nucleus, translocation (GO:0033158)2.27081495
144histone H3-K4 methylation (GO:0051568)2.26823113
145positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.25407053
146histone H4 deacetylation (GO:0070933)2.25072698
147hepatocyte apoptotic process (GO:0097284)2.23116147
148leukocyte cell-cell adhesion (GO:0007159)2.22662757
149B cell receptor signaling pathway (GO:0050853)2.22597097
150regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.21900999
151histone H3-K36 demethylation (GO:0070544)2.21184848
152positive regulation of gene expression, epigenetic (GO:0045815)2.20364118
153positive regulation of B cell activation (GO:0050871)2.20085848
154protein localization to chromosome, centromeric region (GO:0071459)2.19296500
155epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19021057
156spliceosomal tri-snRNP complex assembly (GO:0000244)2.18867635
157negative regulation of interleukin-12 production (GO:0032695)2.18748071
158cellular hyperosmotic response (GO:0071474)2.18024071
159response to laminar fluid shear stress (GO:0034616)2.17659868
160regulation of translational fidelity (GO:0006450)2.16947407
161NLS-bearing protein import into nucleus (GO:0006607)2.16110704
162positive regulation of RNA splicing (GO:0033120)2.15717261
163histone H3-K4 trimethylation (GO:0080182)2.15202839
164regulation of cholesterol storage (GO:0010885)2.14505512
165positive regulation of immunoglobulin production (GO:0002639)2.14155815
166nuclear envelope organization (GO:0006998)2.14005404
167histone deubiquitination (GO:0016578)2.13834380
168regulation of nucleobase-containing compound transport (GO:0032239)2.13311805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.85071633
2E2F7_22180533_ChIP-Seq_HELA_Human4.83968902
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.85558058
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.71578148
5MYC_22102868_ChIP-Seq_BL_Human3.68855571
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.46529653
7* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89883246
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79060882
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.61041574
10* VDR_21846776_ChIP-Seq_THP-1_Human2.48032689
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.39526301
12TCF7_22412390_ChIP-Seq_EML_Mouse2.35143590
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.29451551
14MAF_26560356_Chip-Seq_TH1_Human2.22921352
15* KDM2B_26808549_Chip-Seq_DND41_Human2.14367644
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11893307
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09185268
18* UTX_26944678_Chip-Seq_JUKART_Human1.96616962
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92393923
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88974300
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86927391
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82424015
23* MYB_26560356_Chip-Seq_TH1_Human1.78926846
24* MYB_26560356_Chip-Seq_TH2_Human1.76095087
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75518416
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74777596
27* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73917207
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73563829
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71566810
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71289593
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.70862080
32* ELK3_25401928_ChIP-Seq_HUVEC_Human1.69165560
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67375985
34RUNX_20019798_ChIP-Seq_JUKART_Human1.65276994
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.62994742
36ZNF263_19887448_ChIP-Seq_K562_Human1.61679492
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61099077
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59852474
39* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59303169
40* VDR_24763502_ChIP-Seq_THP-1_Human1.57083507
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57060940
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56145660
43CIITA_25753668_ChIP-Seq_RAJI_Human1.54707021
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51202709
45KDM2B_26808549_Chip-Seq_JURKAT_Human1.50884765
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50574666
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.50558252
48* RUNX1_22412390_ChIP-Seq_EML_Mouse1.50423125
49MAF_26560356_Chip-Seq_TH2_Human1.47417615
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45321507
51* IRF8_27001747_Chip-Seq_BMDM_Mouse1.44434601
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44135725
53SCL_19346495_ChIP-Seq_HPC-7_Human1.43703473
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41672730
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40383608
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38558825
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37493016
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36453095
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36387372
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34846228
61NCOR1_26117541_ChIP-Seq_K562_Human1.33725224
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.33125537
63* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31261091
64* KDM5A_27292631_Chip-Seq_BREAST_Human1.28854086
65* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28323529
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28282051
67P68_20966046_ChIP-Seq_HELA_Human1.27896953
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25825907
69TFEB_21752829_ChIP-Seq_HELA_Human1.25431229
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24477343
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24234594
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24004902
73SPI1_23127762_ChIP-Seq_K562_Human1.23688607
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.23413611
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23004144
76* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20641763
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20270674
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20195958
79FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.19171630
80SPI1_23547873_ChIP-Seq_NB4_Human1.18355446
81LXR_22292898_ChIP-Seq_THP-1_Human1.18014207
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17735514
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.17331918
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16599776
85* SMC4_20622854_ChIP-Seq_HELA_Human1.16430486
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16017759
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15422384
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15352196
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14369973
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14351635
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13412166
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12609078
93ATF3_27146783_Chip-Seq_COLON_Human1.12138685
94* CREB1_26743006_Chip-Seq_LNCaP_Human1.11612648
95* RACK7_27058665_Chip-Seq_MCF-7_Human1.10955608
96* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10729676
97* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10364978
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10218381
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09792832
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09521639
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08921876
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08112292
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07898288
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07334913
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07107772
106* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06887982
107CLOCK_20551151_ChIP-Seq_293T_Human1.06552575
108GATA3_27048872_Chip-Seq_THYMUS_Human1.06260432
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.05653066
110* BCOR_27268052_Chip-Seq_Bcells_Human1.04568868
111HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03814824
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03247412
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.02787462
114* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02658221
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02654841
116PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02129922
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01998237
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01433261
119* CHD1_26751641_Chip-Seq_LNCaP_Human1.00970874
120* GATA6_25053715_ChIP-Seq_YYC3_Human0.99065862
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98442581
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98241196
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98183515
124* MYC_18555785_ChIP-Seq_MESCs_Mouse0.97790185
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96386944
126KDM2B_26808549_Chip-Seq_K562_Human0.95816467
127ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95307845
128* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94212363
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.93466976
130PU_27001747_Chip-Seq_BMDM_Mouse0.92923748
131ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90876516
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90074191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.57321985
2MP0008260_abnormal_autophagy2.97820341
3MP0010352_gastrointestinal_tract_polyps2.86315575
4MP0000685_abnormal_immune_system2.72353939
5MP0003300_gastrointestinal_ulcer2.65758429
6MP0003705_abnormal_hypodermis_morpholog2.62094664
7MP0005076_abnormal_cell_differentiation2.61232159
8MP0009278_abnormal_bone_marrow2.59187418
9MP0001835_abnormal_antigen_presentation2.46486162
10MP0001800_abnormal_humoral_immune2.43734745
11MP0003303_peritoneal_inflammation2.42343302
12MP0005058_abnormal_lysosome_morphology2.30541153
13MP0003436_decreased_susceptibility_to2.28379581
14MP0003191_abnormal_cellular_cholesterol2.24673640
15MP0001790_abnormal_immune_system2.16825631
16MP0005387_immune_system_phenotype2.16825631
17MP0000569_abnormal_digit_pigmentation2.15554297
18MP0004947_skin_inflammation2.02927113
19MP0004808_abnormal_hematopoietic_stem2.02578316
20MP0002398_abnormal_bone_marrow2.02556809
21MP0005671_abnormal_response_to2.01433564
22MP0008961_abnormal_basal_metabolism2.01311229
23MP0002452_abnormal_antigen_presenting1.96597675
24MP0003111_abnormal_nucleus_morphology1.88216699
25MP0003763_abnormal_thymus_physiology1.87522736
26MP0002723_abnormal_immune_serum1.81938260
27MP0002396_abnormal_hematopoietic_system1.79901649
28MP0002420_abnormal_adaptive_immunity1.75143404
29MP0001819_abnormal_immune_cell1.74610910
30MP0005000_abnormal_immune_tolerance1.68598466
31MP0000703_abnormal_thymus_morphology1.67436629
32MP0003724_increased_susceptibility_to1.66564211
33MP0000716_abnormal_immune_system1.63901106
34MP0010155_abnormal_intestine_physiology1.62256594
35MP0010307_abnormal_tumor_latency1.60233782
36MP0004185_abnormal_adipocyte_glucose1.59771032
37MP0005397_hematopoietic_system_phenotyp1.58246212
38MP0001545_abnormal_hematopoietic_system1.58246212
39MP0002722_abnormal_immune_system1.57910312
40MP0002877_abnormal_melanocyte_morpholog1.57720028
41MP0000689_abnormal_spleen_morphology1.56636393
42MP0006082_CNS_inflammation1.52305926
43MP0005025_abnormal_response_to1.52013082
44MP0002405_respiratory_system_inflammati1.51811421
45MP0000490_abnormal_crypts_of1.50386030
46MP0004858_abnormal_nervous_system1.48863091
47MP0002429_abnormal_blood_cell1.46587106
48MP0003693_abnormal_embryo_hatching1.46388795
49MP0003566_abnormal_cell_adhesion1.45474747
50MP0003077_abnormal_cell_cycle1.44405871
51MP0009785_altered_susceptibility_to1.41856110
52MP0005464_abnormal_platelet_physiology1.36399444
53MP0003828_pulmonary_edema1.32511927
54MP0001873_stomach_inflammation1.32263522
55MP0002796_impaired_skin_barrier1.29997767
56MP0003656_abnormal_erythrocyte_physiolo1.28356624
57MP0009333_abnormal_splenocyte_physiolog1.27988479
58MP0000350_abnormal_cell_proliferation1.27717191
59MP0000733_abnormal_muscle_development1.27446191
60MP0002166_altered_tumor_susceptibility1.26895130
61MP0010094_abnormal_chromosome_stability1.26830209
62MP0004197_abnormal_fetal_growth/weight/1.26473994
63MP0000678_abnormal_parathyroid_gland1.25369261
64MP0002254_reproductive_system_inflammat1.24776009
65MP0002419_abnormal_innate_immunity1.22947777
66MP0002086_abnormal_extraembryonic_tissu1.22259624
67MP0004264_abnormal_extraembryonic_tissu1.18978995
68MP0000858_altered_metastatic_potential1.17885605
69MP0002138_abnormal_hepatobiliary_system1.17776224
70MP0001845_abnormal_inflammatory_respons1.16240644
71MP0005023_abnormal_wound_healing1.16173251
72MP0004381_abnormal_hair_follicle1.15514533
73MP0002998_abnormal_bone_remodeling1.13283600
74MP0002088_abnormal_embryonic_growth/wei1.12117505
75MP0002006_tumorigenesis1.11580612
76MP0003984_embryonic_growth_retardation1.11072452
77MP0002019_abnormal_tumor_incidence1.10837436
78MP0005666_abnormal_adipose_tissue1.10069532
79MP0003866_abnormal_defecation1.09757007
80MP0003172_abnormal_lysosome_physiology1.09303098
81MP0005501_abnormal_skin_physiology1.07320695
82MP0001853_heart_inflammation1.06307630
83MP0001672_abnormal_embryogenesis/_devel1.05588760
84MP0005380_embryogenesis_phenotype1.05588760
85MP0003448_altered_tumor_morphology1.05426283
86MP0002148_abnormal_hypersensitivity_rea1.04389776
87MP0010234_abnormal_vibrissa_follicle1.04299890
88MP0003453_abnormal_keratinocyte_physiol1.04055964
89MP0001849_ear_inflammation1.02578573
90MP0001730_embryonic_growth_arrest1.01980849
91MP0004957_abnormal_blastocyst_morpholog1.00729064
92MP0004510_myositis1.00391531
93MP0003091_abnormal_cell_migration0.99971681
94MP0001697_abnormal_embryo_size0.99366354
95MP0008057_abnormal_DNA_replication0.97096407
96MP0009840_abnormal_foam_cell0.92088649
97MP0001348_abnormal_lacrimal_gland0.91713409
98MP0010030_abnormal_orbit_morphology0.91618878
99MP0000371_diluted_coat_color0.91020178
100MP0008007_abnormal_cellular_replicative0.90575128
101MP0002009_preneoplasia0.89999829
102MP0001851_eye_inflammation0.89904935
103MP0001533_abnormal_skeleton_physiology0.89438279
104MP0000003_abnormal_adipose_tissue0.89338566
105MP0003075_altered_response_to0.88488895
106MP0000609_abnormal_liver_physiology0.88175629
107MP0003221_abnormal_cardiomyocyte_apopto0.87433730
108MP0002080_prenatal_lethality0.84813484
109MP0008469_abnormal_protein_level0.83940888
110MP0009931_abnormal_skin_appearance0.83459374
111MP0002060_abnormal_skin_morphology0.82045159
112MP0001216_abnormal_epidermal_layer0.81416975
113MP0003123_paternal_imprinting0.81017830
114MP0009053_abnormal_anal_canal0.81012813
115MP0005621_abnormal_cell_physiology0.78430550
116MP0000767_abnormal_smooth_muscle0.77750706
117MP0000313_abnormal_cell_death0.77525482
118MP0000465_gastrointestinal_hemorrhage0.77454543
119MP0002925_abnormal_cardiovascular_devel0.76482559
120MP0005310_abnormal_salivary_gland0.76082458
121MP0005375_adipose_tissue_phenotype0.75985490
122MP0003045_fibrosis0.74814307
123MP0003252_abnormal_bile_duct0.74496359
124MP0002089_abnormal_postnatal_growth/wei0.73912143
125MP0002132_abnormal_respiratory_system0.72683144
126MP0004233_abnormal_muscle_weight0.72556610
127MP0002933_joint_inflammation0.72315288
128MP0005083_abnormal_biliary_tract0.72026262
129MP0000598_abnormal_liver_morphology0.71797577
130MP0005390_skeleton_phenotype0.67550959
131MP0005384_cellular_phenotype0.66913274

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)3.20893949
2Abnormality of the fingertips (HP:0001211)2.93948403
3Recurrent viral infections (HP:0004429)2.88880478
4Heterotopia (HP:0002282)2.70622077
5Recurrent fungal infections (HP:0002841)2.64168796
6Hyperacusis (HP:0010780)2.63252638
7Broad face (HP:0000283)2.58547187
8Long palpebral fissure (HP:0000637)2.57502171
9T lymphocytopenia (HP:0005403)2.50285562
10Myositis (HP:0100614)2.49648535
11Broad palm (HP:0001169)2.49418761
12Eczematoid dermatitis (HP:0000976)2.49117859
13Increased IgE level (HP:0003212)2.47316228
14Cellulitis (HP:0100658)2.43732248
15Ependymoma (HP:0002888)2.40765649
16Abnormality of the thoracic spine (HP:0100711)2.36217617
17Abnormality of T cell number (HP:0011839)2.33081929
18Colitis (HP:0002583)2.30842172
19Pustule (HP:0200039)2.28747511
20Myocardial infarction (HP:0001658)2.28436415
21Achilles tendon contracture (HP:0001771)2.25449797
22Cerebral aneurysm (HP:0004944)2.25442835
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24205308
24Mediastinal lymphadenopathy (HP:0100721)2.24099633
25Abnormality of the intervertebral disk (HP:0005108)2.21410231
26Thoracic kyphosis (HP:0002942)2.19899092
27Slow saccadic eye movements (HP:0000514)2.19772970
28Obstructive lung disease (HP:0006536)2.18584055
29Chronic obstructive pulmonary disease (HP:0006510)2.18584055
30Vertebral compression fractures (HP:0002953)2.17970269
31Persistence of primary teeth (HP:0006335)2.14466105
32Elevated erythrocyte sedimentation rate (HP:0003565)2.14122780
33Thin bony cortex (HP:0002753)2.12649469
34Increased density of long bones (HP:0006392)2.12577428
35Volvulus (HP:0002580)2.12292392
36Cutis marmorata (HP:0000965)2.11419808
37Loss of speech (HP:0002371)2.10925969
38Gastrointestinal inflammation (HP:0004386)2.10893636
39Long eyelashes (HP:0000527)2.10404270
40Inflammation of the large intestine (HP:0002037)2.09521982
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.09512728
42Obstructive sleep apnea (HP:0002870)2.09470073
43Panhypogammaglobulinemia (HP:0003139)2.09179240
44Gingivitis (HP:0000230)2.06002247
45Verrucae (HP:0200043)2.05451351
46Papilloma (HP:0012740)2.05451351
47Prominent nose (HP:0000448)2.05139999
48Gastrointestinal stroma tumor (HP:0100723)2.04752257
49Segmental peripheral demyelination/remyelination (HP:0003481)2.03613017
50Bicuspid aortic valve (HP:0001647)2.03319469
51Recurrent gram-negative bacterial infections (HP:0005420)2.03020817
52Recurrent bronchitis (HP:0002837)2.02198902
53Stridor (HP:0010307)2.01381482
54Distal lower limb amyotrophy (HP:0008944)2.01048512
55Basal cell carcinoma (HP:0002671)2.00743668
56Abnormality of T cells (HP:0002843)2.00173575
57Broad distal phalanx of finger (HP:0009836)2.00031603
58Autoimmune thrombocytopenia (HP:0001973)1.97707254
59Nasal polyposis (HP:0100582)1.96486892
60Distal upper limb amyotrophy (HP:0007149)1.95789031
61Upper limb amyotrophy (HP:0009129)1.95789031
62Abnormality of the Achilles tendon (HP:0005109)1.95467622
63Disproportionate tall stature (HP:0001519)1.94920267
64Ulnar bowing (HP:0003031)1.94428129
65Increased cerebral lipofuscin (HP:0011813)1.93957704
66Agammaglobulinemia (HP:0004432)1.93779427
67Subacute progressive viral hepatitis (HP:0006572)1.92488822
68Neoplasm of the tracheobronchial system (HP:0100552)1.92002173
69Gastrointestinal infarctions (HP:0005244)1.91816902
70Increased connective tissue (HP:0009025)1.89382519
71Dysostosis multiplex (HP:0000943)1.89316194
72Aneurysm (HP:0002617)1.89047986
73Urethral obstruction (HP:0000796)1.87650930
74Viral hepatitis (HP:0006562)1.86676412
75Hypertensive crisis (HP:0100735)1.86591970
76Polygenic inheritance (HP:0010982)1.85891794
77Metaphyseal cupping (HP:0003021)1.85716419
78Emphysema (HP:0002097)1.84691339
79Recurrent skin infections (HP:0001581)1.84541547
80Orchitis (HP:0100796)1.84258707
81Neuronal loss in central nervous system (HP:0002529)1.84036201
82Increased nuchal translucency (HP:0010880)1.84012262
83Large earlobe (HP:0009748)1.83527406
84Aortic aneurysm (HP:0004942)1.83445243
85Arterial thrombosis (HP:0004420)1.83134523
86Upper motor neuron abnormality (HP:0002127)1.82352401
87Chest pain (HP:0100749)1.82349280
88Abnormality of the distal phalanges of the toes (HP:0010182)1.82145302
89Sparse lateral eyebrow (HP:0005338)1.80810108
90Vasculitis (HP:0002633)1.80678019
91Poikiloderma (HP:0001029)1.79110783
92Micronodular cirrhosis (HP:0001413)1.78392778
93Genu recurvatum (HP:0002816)1.77506744
94Alveolar cell carcinoma (HP:0006519)1.77440269
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.77353306
96Flat acetabular roof (HP:0003180)1.75843015
97B lymphocytopenia (HP:0010976)1.75561945
98Abnormality of B cell number (HP:0010975)1.75561945
99Mitral regurgitation (HP:0001653)1.74786927
100Abnormality of the columella (HP:0009929)1.74653511
101Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74224222
102Prominent metopic ridge (HP:0005487)1.73294336
103Abnormality of glycolipid metabolism (HP:0010969)1.72999653
104Abnormality of liposaccharide metabolism (HP:0010968)1.72999653
105Abnormality of glycosphingolipid metabolism (HP:0004343)1.72999653
106Diaphragmatic weakness (HP:0009113)1.72771569
107Interstitial pulmonary disease (HP:0006530)1.71702579
108Pulmonary infiltrates (HP:0002113)1.71464109
109Stomatitis (HP:0010280)1.71239217
110IgA deficiency (HP:0002720)1.70800168
111Pelvic girdle muscle weakness (HP:0003749)1.70637228
112Recurrent cutaneous fungal infections (HP:0011370)1.70341555
113Chronic mucocutaneous candidiasis (HP:0002728)1.70341555
114Increased serum ferritin (HP:0003281)1.69213412
115Gastrointestinal carcinoma (HP:0002672)1.69030919
116Malignant gastrointestinal tract tumors (HP:0006749)1.69030919
117Abnormality of the astrocytes (HP:0100707)1.68778866
118Astrocytoma (HP:0009592)1.68778866
119Optic neuritis (HP:0100653)1.68547000
120Retrobulbar optic neuritis (HP:0100654)1.68547000
121Recurrent abscess formation (HP:0002722)1.67759559
122Meningitis (HP:0001287)1.67089254
123Spinal cord lesions (HP:0100561)1.66399192
124Syringomyelia (HP:0003396)1.66399192
125Limited elbow extension (HP:0001377)1.65884143
126Short 4th metacarpal (HP:0010044)1.65642416
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65642416
128Easy fatigability (HP:0003388)1.65568001
129Porencephaly (HP:0002132)1.64719597
130Mitral valve prolapse (HP:0001634)1.64715956
131Obsessive-compulsive behavior (HP:0000722)1.64552807
132Polycythemia (HP:0001901)1.64496691
133Urticaria (HP:0001025)1.64246025
134Hypercortisolism (HP:0001578)1.63948378
135Centrally nucleated skeletal muscle fibers (HP:0003687)1.63615861
136Recurrent bacterial skin infections (HP:0005406)1.63292496
137High pitched voice (HP:0001620)1.63290034
138Flattened epiphyses (HP:0003071)1.63045617
139Sepsis (HP:0100806)1.62989454
140Hemorrhage of the eye (HP:0011885)1.62168023
141Biconcave vertebral bodies (HP:0004586)1.61996726
142Dilatation of the ascending aorta (HP:0005111)1.61890554
143Dislocated radial head (HP:0003083)1.61678525
144Chronic otitis media (HP:0000389)1.61589507
145Prolonged bleeding time (HP:0003010)1.61161145
146Lymphopenia (HP:0001888)1.61117184
147Deviation of the thumb (HP:0009603)1.61024253
148Reticulocytosis (HP:0001923)1.59937485
149Thrombocytosis (HP:0001894)1.59365512
150Abnormality of cells of the lymphoid lineage (HP:0012140)1.59253215
151Proximal placement of thumb (HP:0009623)1.59051144
152Renal duplication (HP:0000075)1.58906452
153Deep palmar crease (HP:0006191)1.58831196
154Osteomyelitis (HP:0002754)1.58815495
155Abnormality of the nasal mucosa (HP:0000433)1.58657659
156Combined immunodeficiency (HP:0005387)1.58411205
157Pointed chin (HP:0000307)1.58194889
158Neoplasm of the respiratory system (HP:0100606)1.57950711
159Hyperparathyroidism (HP:0000843)1.56909643
160Increased neuronal autofluorescent lipopigment (HP:0002074)1.56851434
161Narrow palate (HP:0000189)1.56371497
162Gingival bleeding (HP:0000225)1.55482224
163Restrictive lung disease (HP:0002091)1.55154922
164Cortical dysplasia (HP:0002539)1.54188038
165Hypochromic anemia (HP:0001931)1.53993170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.38872504
2MAP3K103.55542046
3CDK123.23016494
4SMG13.12013317
5MAP4K13.06328262
6IRAK33.02715370
7ERN13.00572084
8TRIB32.91847585
9EEF2K2.74691987
10PKN22.12902094
11SIK32.10516979
12FGFR41.94677003
13TAOK21.90014652
14JAK31.81074415
15ZAP701.77732098
16STK101.77066824
17PTK61.70144129
18MAP2K31.70097691
19SIK21.69120642
20TBK11.66308633
21RIPK41.62313906
22TAOK11.59848691
23SIK11.59038786
24GRK61.58750438
25TYK21.50190990
26CDK61.46271122
27ALK1.46029400
28MAP3K131.41662207
29ICK1.41627124
30IKBKB1.40640192
31FGFR31.33531442
32NEK21.32316437
33RPS6KB21.30505674
34CDK41.29904745
35CHUK1.29362180
36EPHA21.28667717
37ITK1.24938839
38MAP3K141.18782292
39MAP3K11.18352522
40LATS11.17972528
41IKBKE1.17770902
42RIPK11.15708709
43CAMK1D1.15311514
44TXK1.11553152
45TTN1.11113773
46JAK11.10987302
47EPHB11.10440466
48DMPK1.07040371
49MAP3K111.06665893
50FLT31.05824613
51MTOR1.05152421
52RPS6KA41.04347826
53BLK1.03382419
54TESK21.03281211
55PIM11.02831919
56CDK90.99892923
57STK30.98966961
58PRKD20.96968465
59TGFBR20.96968044
60BMPR20.96771708
61KSR20.95498488
62TNK20.95334348
63JAK20.93883773
64CAMK1G0.93599139
65MARK30.93551006
66BRD40.92676913
67LRRK20.91304726
68PDGFRA0.90623701
69CDC42BPA0.89248850
70STK40.88920812
71MAP3K30.88611086
72BTK0.87590240
73HIPK20.85580459
74HCK0.84982889
75CSK0.84312142
76MELK0.82399848
77RPS6KC10.79610748
78RPS6KL10.79610748
79BRAF0.78737845
80BMX0.78214853
81PDPK10.77764701
82KSR10.77572431
83SYK0.77164746
84MAP2K20.76396263
85CDC70.75902991
86ARAF0.75898265
87NUAK10.74664988
88ERBB20.74244032
89TYRO30.73131136
90MAP3K80.69954832
91IRAK40.69551867
92RPS6KA20.69269766
93PDGFRB0.68759500
94SCYL20.68697246
95MAP3K50.68552556
96NME20.68321668
97ATR0.68175583
98IRAK20.65614629
99MAP3K70.64089887
100FGFR10.63853109
101EIF2AK10.60647799
102EPHB20.60053483
103IRAK10.59374319
104MAPK110.58625349
105MARK20.58310506
106PAK20.57850233
107RPS6KA60.57849277
108RPS6KA10.57772244
109PDK10.57415587
110FES0.57174318
111CSF1R0.54701197
112SGK30.54170369
113FGR0.54089654
114DYRK1B0.53839260
115PAK40.52578516
116CAMKK10.51937947
117LCK0.51645530
118CHEK10.51357520
119MST1R0.50691098
120CDK70.50531261
121TGFBR10.49213400
122RET0.48926350
123GSK3A0.46760602
124MAPK70.46586716
125MAPK120.45163699
126CDK190.43159208
127TAOK30.43122626
128PIM20.40185058
129CLK10.38584811
130PRKAA10.38534606
131CDK20.38518450
132PASK0.37352574
133MAPKAPK20.37077025
134LMTK20.37014150
135MAP3K90.36627357
136LYN0.36127650

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.14500336
2B cell receptor signaling pathway_Homo sapiens_hsa046622.03094226
3Primary immunodeficiency_Homo sapiens_hsa053402.03084805
4Chronic myeloid leukemia_Homo sapiens_hsa052202.02134589
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.97259415
6T cell receptor signaling pathway_Homo sapiens_hsa046601.95954103
7Leishmaniasis_Homo sapiens_hsa051401.81902725
8Osteoclast differentiation_Homo sapiens_hsa043801.79864352
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70608137
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.70050056
11Acute myeloid leukemia_Homo sapiens_hsa052211.69673584
12Measles_Homo sapiens_hsa051621.69552037
13TNF signaling pathway_Homo sapiens_hsa046681.65052651
14Herpes simplex infection_Homo sapiens_hsa051681.63452774
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62645881
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54532099
17Pancreatic cancer_Homo sapiens_hsa052121.54360637
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.54031294
19Apoptosis_Homo sapiens_hsa042101.51830402
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50932375
21mTOR signaling pathway_Homo sapiens_hsa041501.49155887
22Hepatitis B_Homo sapiens_hsa051611.46834616
23Influenza A_Homo sapiens_hsa051641.45977161
24Graft-versus-host disease_Homo sapiens_hsa053321.42348291
25Notch signaling pathway_Homo sapiens_hsa043301.40921437
26Toxoplasmosis_Homo sapiens_hsa051451.38310047
27Lysine degradation_Homo sapiens_hsa003101.38155726
28Non-small cell lung cancer_Homo sapiens_hsa052231.34823925
29Antigen processing and presentation_Homo sapiens_hsa046121.33924822
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31715866
31Legionellosis_Homo sapiens_hsa051341.31655803
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.30347834
33MicroRNAs in cancer_Homo sapiens_hsa052061.27500648
34Thyroid cancer_Homo sapiens_hsa052161.26771495
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.26241010
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26230430
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23906855
38Shigellosis_Homo sapiens_hsa051311.23047520
39Prolactin signaling pathway_Homo sapiens_hsa049171.20269501
40One carbon pool by folate_Homo sapiens_hsa006701.19744295
41Colorectal cancer_Homo sapiens_hsa052101.19463323
42Small cell lung cancer_Homo sapiens_hsa052221.19362859
43Viral myocarditis_Homo sapiens_hsa054161.17937522
44Viral carcinogenesis_Homo sapiens_hsa052031.17403990
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.13751928
46Insulin resistance_Homo sapiens_hsa049311.12636726
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12417439
48ErbB signaling pathway_Homo sapiens_hsa040121.08786101
49HTLV-I infection_Homo sapiens_hsa051661.07601476
50Endometrial cancer_Homo sapiens_hsa052131.07222625
51mRNA surveillance pathway_Homo sapiens_hsa030151.04978807
52Chemokine signaling pathway_Homo sapiens_hsa040621.00184293
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98206206
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95559388
55VEGF signaling pathway_Homo sapiens_hsa043700.95188610
56Tuberculosis_Homo sapiens_hsa051520.94993739
57Proteoglycans in cancer_Homo sapiens_hsa052050.94978587
58Prion diseases_Homo sapiens_hsa050200.94244629
59FoxO signaling pathway_Homo sapiens_hsa040680.93513867
60Hematopoietic cell lineage_Homo sapiens_hsa046400.92721544
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92488222
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.91863728
63Cell cycle_Homo sapiens_hsa041100.88644438
64Selenocompound metabolism_Homo sapiens_hsa004500.87397502
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.86188333
66Hepatitis C_Homo sapiens_hsa051600.84723288
67p53 signaling pathway_Homo sapiens_hsa041150.84309470
68Choline metabolism in cancer_Homo sapiens_hsa052310.83538530
69Prostate cancer_Homo sapiens_hsa052150.82788785
70Pentose phosphate pathway_Homo sapiens_hsa000300.81449364
71Epstein-Barr virus infection_Homo sapiens_hsa051690.81348359
72RNA transport_Homo sapiens_hsa030130.80891351
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.80447564
74Endocytosis_Homo sapiens_hsa041440.79980872
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.79518491
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.79061059
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76994157
78Salmonella infection_Homo sapiens_hsa051320.75877339
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75434311
80Lysosome_Homo sapiens_hsa041420.75218401
81Pertussis_Homo sapiens_hsa051330.73604703
82Allograft rejection_Homo sapiens_hsa053300.72918616
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72668235
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.72406873
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71221250
86Adherens junction_Homo sapiens_hsa045200.70103613
87Platelet activation_Homo sapiens_hsa046110.70052733
88Type II diabetes mellitus_Homo sapiens_hsa049300.69018216
89Renal cell carcinoma_Homo sapiens_hsa052110.68308380
90Galactose metabolism_Homo sapiens_hsa000520.67498103
91Fructose and mannose metabolism_Homo sapiens_hsa000510.65807864
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65683579
93Glioma_Homo sapiens_hsa052140.65019428
94Bladder cancer_Homo sapiens_hsa052190.64756932
95GnRH signaling pathway_Homo sapiens_hsa049120.64727852
96Insulin signaling pathway_Homo sapiens_hsa049100.64277250
97Malaria_Homo sapiens_hsa051440.63757478
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63599600
99HIF-1 signaling pathway_Homo sapiens_hsa040660.62494766
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62433077
101Inositol phosphate metabolism_Homo sapiens_hsa005620.62214841
102Amoebiasis_Homo sapiens_hsa051460.60754280
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60251383
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59392065
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59373142
106Autoimmune thyroid disease_Homo sapiens_hsa053200.58716197
107Spliceosome_Homo sapiens_hsa030400.58676100
108MAPK signaling pathway_Homo sapiens_hsa040100.57908710
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56524854
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55810249
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55457917
112AMPK signaling pathway_Homo sapiens_hsa041520.54414499
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53972776
114Type I diabetes mellitus_Homo sapiens_hsa049400.51005328
115DNA replication_Homo sapiens_hsa030300.50934686
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50602638
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50374590
118Staphylococcus aureus infection_Homo sapiens_hsa051500.49917027
119Base excision repair_Homo sapiens_hsa034100.49877023
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48374101

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