GMFB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.94817875
2membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.93416191
3synaptic vesicle maturation (GO:0016188)5.75440600
4membrane repolarization during action potential (GO:0086011)5.41238393
5parturition (GO:0007567)5.37343252
6locomotory exploration behavior (GO:0035641)5.17593659
7synaptic vesicle exocytosis (GO:0016079)4.99724228
8regulation of synaptic vesicle exocytosis (GO:2000300)4.94158796
9glutamate secretion (GO:0014047)4.91344495
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.85894093
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.84302679
12regulation of DNA endoreduplication (GO:0032875)4.79497988
13layer formation in cerebral cortex (GO:0021819)4.51436576
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43801675
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.42905209
16fat-soluble vitamin catabolic process (GO:0042363)4.39584207
17vitamin catabolic process (GO:0009111)4.39584207
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.38091310
19membrane repolarization (GO:0086009)4.30939411
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27123408
21proline transport (GO:0015824)4.26135264
22vocalization behavior (GO:0071625)4.25717651
23regulation of synaptic vesicle transport (GO:1902803)4.15438065
24exploration behavior (GO:0035640)4.08672183
25regulation of glutamate receptor signaling pathway (GO:1900449)4.05626004
26neurotransmitter secretion (GO:0007269)4.04418910
27cell proliferation in forebrain (GO:0021846)4.01614043
28magnesium ion transport (GO:0015693)3.95299125
29protein localization to synapse (GO:0035418)3.94412697
30piRNA metabolic process (GO:0034587)3.87593328
31regulation of membrane repolarization (GO:0060306)3.83276131
32clathrin coat assembly (GO:0048268)3.83222682
33regulation of synapse structural plasticity (GO:0051823)3.80953849
34regulation of meiosis I (GO:0060631)3.76515355
35neuron cell-cell adhesion (GO:0007158)3.74966924
36vesicle transport along microtubule (GO:0047496)3.73691374
37regulation of mesoderm development (GO:2000380)3.72507607
38regulation of neuronal synaptic plasticity (GO:0048168)3.64964176
39activation of protein kinase A activity (GO:0034199)3.62307403
40positive regulation of male gonad development (GO:2000020)3.61074092
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59848570
42dendrite morphogenesis (GO:0048813)3.56474252
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.53290192
44cellular anion homeostasis (GO:0030002)3.52648536
45negative regulation of response to food (GO:0032096)3.52101170
46negative regulation of appetite (GO:0032099)3.52101170
47regulation of potassium ion transmembrane transport (GO:1901379)3.45864698
48neuronal action potential propagation (GO:0019227)3.44191295
49organelle transport along microtubule (GO:0072384)3.42634126
50positive regulation of potassium ion transmembrane transport (GO:1901381)3.42072332
51neurotransmitter-gated ion channel clustering (GO:0072578)3.39001702
52regulation of cAMP-dependent protein kinase activity (GO:2000479)3.38409465
53ionotropic glutamate receptor signaling pathway (GO:0035235)3.37369850
54DNA methylation involved in gamete generation (GO:0043046)3.37181806
55retinal ganglion cell axon guidance (GO:0031290)3.34961379
56somite development (GO:0061053)3.34913939
57regulation of synapse maturation (GO:0090128)3.31869338
58establishment of nucleus localization (GO:0040023)3.30338001
59cellular response to electrical stimulus (GO:0071257)3.29655234
60water-soluble vitamin biosynthetic process (GO:0042364)3.24358012
61protein polyglutamylation (GO:0018095)3.22740172
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20073137
63negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.19891507
64gamma-aminobutyric acid transport (GO:0015812)3.16330862
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.15738519
66NADH dehydrogenase complex assembly (GO:0010257)3.15738519
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15738519
68cellular potassium ion homeostasis (GO:0030007)3.15244618
69innervation (GO:0060384)3.11940277
70regulation of male gonad development (GO:2000018)3.11926110
71sodium ion export (GO:0071436)3.10924558
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09657462
73neuron-neuron synaptic transmission (GO:0007270)3.09442964
74synaptic transmission, glutamatergic (GO:0035249)3.08439041
75negative regulation of dendrite morphogenesis (GO:0050774)3.06649922
76regulation of dendritic spine morphogenesis (GO:0061001)3.06606820
77positive regulation of meiosis (GO:0045836)3.06412391
78regulation of excitatory postsynaptic membrane potential (GO:0060079)3.05601704
79negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05482743
80pyrimidine nucleobase catabolic process (GO:0006208)3.05266790
81neuromuscular process controlling balance (GO:0050885)3.04269019
82substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.03668154
83substrate-independent telencephalic tangential migration (GO:0021826)3.03668154
84axonal fasciculation (GO:0007413)3.03578321
85trivalent inorganic anion homeostasis (GO:0072506)3.03571673
86phosphate ion homeostasis (GO:0055062)3.03571673
87nerve growth factor signaling pathway (GO:0038180)3.03403057
88long-term synaptic potentiation (GO:0060291)3.03258369
89axon extension (GO:0048675)3.02971616
90transmission of nerve impulse (GO:0019226)3.02791124
91regulation of glomerulus development (GO:0090192)3.02673855
92neuron recognition (GO:0008038)3.02585722
93neurotransmitter transport (GO:0006836)3.01830467
94ovulation cycle (GO:0042698)3.01362123
95negative regulation of microtubule polymerization (GO:0031115)3.00245205
96negative regulation of sodium ion transport (GO:0010766)2.99857330
97regulation of synaptic plasticity (GO:0048167)2.99579779
98striatum development (GO:0021756)2.99516668
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.98174518
100endoderm formation (GO:0001706)2.98078325
101regulation of neurotransmitter secretion (GO:0046928)2.97183449
102positive regulation of fibroblast migration (GO:0010763)2.97124142
103regulation of skeletal muscle contraction (GO:0014819)2.96470701
104serotonin metabolic process (GO:0042428)2.95241893
105dendritic spine morphogenesis (GO:0060997)2.95209606
106regulation of potassium ion transmembrane transporter activity (GO:1901016)2.94036016
107negative regulation of DNA-dependent DNA replication (GO:2000104)2.90018742
108positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88904912
109positive regulation of synapse maturation (GO:0090129)2.88110172
110membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87882380
111negative regulation of transcription regulatory region DNA binding (GO:2000678)2.86840350
112prepulse inhibition (GO:0060134)2.86593062
113positive regulation of axon extension (GO:0045773)2.86472632
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84871374
115positive regulation of meiotic cell cycle (GO:0051446)2.84705441
116chaperone-mediated protein transport (GO:0072321)2.84703143
117regulation of neurotransmitter transport (GO:0051588)2.83537851
118vitamin D metabolic process (GO:0042359)2.83460812
119synapse assembly (GO:0007416)2.82591289
120regulation of postsynaptic membrane potential (GO:0060078)2.82547001
121protein complex biogenesis (GO:0070271)2.82318547
122axon cargo transport (GO:0008088)2.81431686
123nonmotile primary cilium assembly (GO:0035058)2.81378607
124glutamate receptor signaling pathway (GO:0007215)2.81061274
125synaptic vesicle endocytosis (GO:0048488)2.80270271
126neuron projection extension (GO:1990138)2.79995408
127positive regulation of cardiac muscle cell differentiation (GO:2000727)2.78084689
128regulation of neurotransmitter levels (GO:0001505)2.76911846
129calcium ion-dependent exocytosis (GO:0017156)2.76703288
130regulation of synaptic transmission, GABAergic (GO:0032228)2.76223344
131postsynaptic membrane organization (GO:0001941)2.75079107
132regulation of heart rate by cardiac conduction (GO:0086091)2.75078400
133potassium ion import (GO:0010107)2.74696089
134positive regulation of membrane potential (GO:0045838)2.74528141
135negative regulation of potassium ion transmembrane transport (GO:1901380)2.74494521
136cerebellar Purkinje cell differentiation (GO:0021702)2.73896842
137presynaptic membrane assembly (GO:0097105)2.72487367
138cell migration in hindbrain (GO:0021535)2.70874435
139mating behavior (GO:0007617)2.70421744
140response to auditory stimulus (GO:0010996)2.70412471
141positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68445745
142primary amino compound metabolic process (GO:1901160)2.67627701
143spinal cord development (GO:0021510)2.67614667
144adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.66689401
145positive regulation of synaptic transmission (GO:0050806)2.66380912
146sex differentiation (GO:0007548)2.64949919
147negative regulation of dendrite development (GO:2000171)2.64095730
148cytoskeletal anchoring at plasma membrane (GO:0007016)2.63662190
149dopamine receptor signaling pathway (GO:0007212)2.63356503
150behavioral fear response (GO:0001662)2.61828882
151behavioral defense response (GO:0002209)2.61828882
152negative regulation of systemic arterial blood pressure (GO:0003085)2.60520038
153long-term memory (GO:0007616)2.60301425
154mitochondrial respiratory chain complex assembly (GO:0033108)2.60161414
155cerebellar granule cell differentiation (GO:0021707)2.59048539
156regulation of vesicle fusion (GO:0031338)2.58989882
157multicellular organismal signaling (GO:0035637)2.58821292
158negative regulation of protein localization to cell surface (GO:2000009)2.58817740
159regulation of synaptic transmission (GO:0050804)2.56752426
160regulation of ARF protein signal transduction (GO:0032012)2.56272664
161membrane depolarization during action potential (GO:0086010)2.56236202
162DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.55461408
163presynaptic membrane organization (GO:0097090)2.55202598
164regulation of potassium ion transport (GO:0043266)2.54422781
165synapse organization (GO:0050808)2.54122330
166actin filament capping (GO:0051693)2.53952902
167G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.53881664
168auditory behavior (GO:0031223)2.53788744
169mesenchymal to epithelial transition (GO:0060231)2.53482633
170fear response (GO:0042596)2.52757180
171head development (GO:0060322)2.52149017
172chaperone-mediated protein complex assembly (GO:0051131)2.51723379
173resolution of meiotic recombination intermediates (GO:0000712)2.51624654
174regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51615472
175neurofilament cytoskeleton organization (GO:0060052)2.51579976
176negative regulation of astrocyte differentiation (GO:0048712)2.50170066
177neuromuscular process (GO:0050905)2.49744966
178positive regulation of potassium ion transport (GO:0043268)2.49250638
179male meiosis I (GO:0007141)2.43717617
180synaptic transmission, cholinergic (GO:0007271)2.42606821
181DNA damage response, signal transduction resulting in transcription (GO:0042772)2.39626041
182lung-associated mesenchyme development (GO:0060484)2.38910403
183sex determination (GO:0007530)2.38618083
184negative regulation of axon extension involved in axon guidance (GO:0048843)2.37992412
185otic vesicle formation (GO:0030916)2.36516039
186potassium ion homeostasis (GO:0055075)2.34757394
187protein neddylation (GO:0045116)2.33533069
188negative regulation of membrane potential (GO:0045837)2.33148327
189seminiferous tubule development (GO:0072520)2.32625370
190nucleobase catabolic process (GO:0046113)2.31396239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.29189975
2GBX2_23144817_ChIP-Seq_PC3_Human3.34387108
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98143450
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.92421294
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65150528
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64680887
7VDR_22108803_ChIP-Seq_LS180_Human2.47240098
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31984165
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27782963
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26460542
11AR_21572438_ChIP-Seq_LNCaP_Human2.23930707
12IRF1_19129219_ChIP-ChIP_H3396_Human2.22904781
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.22379709
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22301417
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20484194
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20428974
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20428974
18RNF2_27304074_Chip-Seq_NSC_Mouse2.18044508
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.14543534
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13544620
21REST_21632747_ChIP-Seq_MESCs_Mouse2.09331406
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07478664
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06753288
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06568878
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04078754
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03891956
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92767949
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91939419
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.88697510
30TAF15_26573619_Chip-Seq_HEK293_Human1.88563663
31DROSHA_22980978_ChIP-Seq_HELA_Human1.87371775
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86276797
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82826574
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82444463
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76363702
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.73393284
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.68786795
38ZNF274_21170338_ChIP-Seq_K562_Hela1.66190140
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.66133606
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.66075970
41P300_19829295_ChIP-Seq_ESCs_Human1.65806185
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.64525907
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62553361
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61734671
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61578474
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60985124
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.60328495
48* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59694249
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59688606
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58018473
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55625170
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.55037096
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.54634507
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53933641
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51719492
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.50543972
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50492493
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49793055
59* AR_25329375_ChIP-Seq_VCAP_Human1.48004300
60STAT3_23295773_ChIP-Seq_U87_Human1.47679946
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46975445
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46461728
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44209905
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41850531
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41379380
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40293908
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37220104
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.37110010
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37082918
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.35490815
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.34997906
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33542159
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.32722595
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32704570
75TP53_16413492_ChIP-PET_HCT116_Human1.32018051
76AHR_22903824_ChIP-Seq_MCF-7_Human1.31130667
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29605993
78* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26851380
79TP53_18474530_ChIP-ChIP_U2OS_Human1.26109095
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24831418
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24565960
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24153966
83FUS_26573619_Chip-Seq_HEK293_Human1.23380168
84ER_23166858_ChIP-Seq_MCF-7_Human1.22271070
85TCF4_23295773_ChIP-Seq_U87_Human1.20692079
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.20624567
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.20466791
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.19722387
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18909380
90* AR_19668381_ChIP-Seq_PC3_Human1.18463680
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18349853
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18349853
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18070903
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17594060
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17561580
96JUN_21703547_ChIP-Seq_K562_Human1.16867391
97* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16759604
98RXR_22108803_ChIP-Seq_LS180_Human1.16607393
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16576295
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16320588
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16320588
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15745941
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.15703197
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14827835
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14552604
106BCAT_22108803_ChIP-Seq_LS180_Human1.13298198
107MYC_18940864_ChIP-ChIP_HL60_Human1.11687053
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11140966
109* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10646308
110SALL1_21062744_ChIP-ChIP_HESCs_Human1.09078827
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08315656
112RUNX2_22187159_ChIP-Seq_PCA_Human1.06924216
113SMAD3_21741376_ChIP-Seq_ESCs_Human1.06792115
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.06626244
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06285637
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06275382
117GABP_17652178_ChIP-ChIP_JURKAT_Human1.04954990
118EP300_21415370_ChIP-Seq_HL-1_Mouse1.03314484
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03158883
120IGF1R_20145208_ChIP-Seq_DFB_Human1.03155751
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.02633394
122SOX2_16153702_ChIP-ChIP_HESCs_Human1.02602521
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02413958
124CBP_20019798_ChIP-Seq_JUKART_Human1.02130183
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02130183
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01477301
127TCF4_18268006_ChIP-ChIP_LS174T_Human1.00318715
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00008794
129ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99430340
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.98450415
131EWS_26573619_Chip-Seq_HEK293_Human0.97299368
132FLI1_21867929_ChIP-Seq_TH2_Mouse0.97153995
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96874663
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96781682
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.96541158
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95775233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.13840504
2MP0004270_analgesia3.89263939
3MP0003635_abnormal_synaptic_transmissio3.72754637
4MP0001968_abnormal_touch/_nociception3.61285722
5MP0003880_abnormal_central_pattern3.48805225
6MP0006292_abnormal_olfactory_placode3.24289744
7MP0002735_abnormal_chemical_nociception3.15050212
8* MP0002063_abnormal_learning/memory/cond3.04405614
9MP0002160_abnormal_reproductive_system3.03215185
10MP0002734_abnormal_mechanical_nocicepti2.90930925
11MP0002736_abnormal_nociception_after2.87971006
12MP0009745_abnormal_behavioral_response2.84455242
13MP0004858_abnormal_nervous_system2.83960724
14MP0009046_muscle_twitch2.75535555
15MP0002064_seizures2.70456441
16MP0002733_abnormal_thermal_nociception2.38435969
17MP0009780_abnormal_chondrocyte_physiolo2.35493116
18MP0002572_abnormal_emotion/affect_behav2.33033651
19MP0000569_abnormal_digit_pigmentation2.29419957
20MP0003123_paternal_imprinting2.26210967
21MP0005423_abnormal_somatic_nervous2.25169831
22MP0005389_reproductive_system_phenotype2.20780120
23MP0004811_abnormal_neuron_physiology2.17090198
24MP0001970_abnormal_pain_threshold2.12042743
25MP0001485_abnormal_pinna_reflex2.07970482
26MP0002272_abnormal_nervous_system2.03297368
27MP0003646_muscle_fatigue2.00169630
28MP0002837_dystrophic_cardiac_calcinosis1.98509020
29MP0000778_abnormal_nervous_system1.97842275
30MP0003890_abnormal_embryonic-extraembry1.91132651
31MP0001486_abnormal_startle_reflex1.90867724
32MP0002184_abnormal_innervation1.88817225
33MP0008789_abnormal_olfactory_epithelium1.87666837
34MP0002067_abnormal_sensory_capabilities1.87502927
35MP0010234_abnormal_vibrissa_follicle1.83617453
36MP0001440_abnormal_grooming_behavior1.80285358
37MP0002102_abnormal_ear_morphology1.76294698
38MP0000013_abnormal_adipose_tissue1.75800426
39MP0002653_abnormal_ependyma_morphology1.75154827
40MP0005623_abnormal_meninges_morphology1.68174006
41MP0000049_abnormal_middle_ear1.67969293
42MP0000955_abnormal_spinal_cord1.67003353
43MP0008569_lethality_at_weaning1.63725531
44MP0003329_amyloid_beta_deposits1.63533388
45MP0000631_abnormal_neuroendocrine_gland1.63456433
46MP0004145_abnormal_muscle_electrophysio1.62332932
47MP0002638_abnormal_pupillary_reflex1.60557167
48MP0005499_abnormal_olfactory_system1.58986702
49MP0005394_taste/olfaction_phenotype1.58986702
50MP0001501_abnormal_sleep_pattern1.58609455
51MP0005551_abnormal_eye_electrophysiolog1.57430200
52MP0003567_abnormal_fetal_cardiomyocyte1.51926408
53MP0003633_abnormal_nervous_system1.51043667
54MP0006072_abnormal_retinal_apoptosis1.50287356
55MP0003119_abnormal_digestive_system1.49850108
56MP0003787_abnormal_imprinting1.49355250
57MP0004142_abnormal_muscle_tone1.48172435
58MP0004924_abnormal_behavior1.47885404
59MP0005386_behavior/neurological_phenoty1.47885404
60MP0006276_abnormal_autonomic_nervous1.47188684
61MP0002909_abnormal_adrenal_gland1.47022605
62MP0001542_abnormal_bone_strength1.43774996
63MP0002557_abnormal_social/conspecific_i1.43532358
64MP0001299_abnormal_eye_distance/1.43363659
65MP0002822_catalepsy1.41485118
66MP0004885_abnormal_endolymph1.41170552
67MP0004133_heterotaxia1.40959126
68MP0001177_atelectasis1.40573237
69MP0003011_delayed_dark_adaptation1.40385283
70MP0003937_abnormal_limbs/digits/tail_de1.38138823
71MP0003634_abnormal_glial_cell1.36760772
72MP0002163_abnormal_gland_morphology1.35798942
73MP0003631_nervous_system_phenotype1.31978553
74MP0001293_anophthalmia1.29246897
75MP0002882_abnormal_neuron_morphology1.29065912
76MP0008438_abnormal_cutaneous_collagen1.27737936
77MP0002752_abnormal_somatic_nervous1.24740050
78* MP0002066_abnormal_motor_capabilities/c1.24718460
79MP0000920_abnormal_myelination1.24017244
80MP0003315_abnormal_perineum_morphology1.23542914
81MP0001919_abnormal_reproductive_system1.22580021
82MP0002210_abnormal_sex_determination1.20945706
83MP0001958_emphysema1.19698627
84MP0009053_abnormal_anal_canal1.16887469
85MP0005195_abnormal_posterior_eye1.15858200
86MP0000604_amyloidosis1.15219454
87MP0001529_abnormal_vocalization1.15093683
88MP0000026_abnormal_inner_ear1.13561629
89MP0003632_abnormal_nervous_system1.11086578
90MP0009250_abnormal_appendicular_skeleto1.10848219
91MP0005187_abnormal_penis_morphology1.07784888
92MP0005253_abnormal_eye_physiology1.06308490
93MP0003183_abnormal_peptide_metabolism1.05991530
94MP0003136_yellow_coat_color1.05400351
95MP0010386_abnormal_urinary_bladder1.03825843
96MP0003172_abnormal_lysosome_physiology1.02848904
97MP0000534_abnormal_ureter_morphology1.02608624
98* MP0002152_abnormal_brain_morphology1.00336784
99MP0001145_abnormal_male_reproductive1.00312601
100MP0003690_abnormal_glial_cell1.00041594
101MP0000537_abnormal_urethra_morphology0.99918191
102MP0004019_abnormal_vitamin_homeostasis0.98800764
103MP0003938_abnormal_ear_development0.95860321
104MP0009384_cardiac_valve_regurgitation0.95835919
105MP0003122_maternal_imprinting0.95475004
106MP0000653_abnormal_sex_gland0.94916475
107MP0004215_abnormal_myocardial_fiber0.94829036
108MP0008995_early_reproductive_senescence0.93601190
109MP0002938_white_spotting0.93007260
110MP0001348_abnormal_lacrimal_gland0.91806167
111MP0001188_hyperpigmentation0.91779902
112MP0005171_absent_coat_pigmentation0.90524807
113MP0009379_abnormal_foot_pigmentation0.89080910
114MP0005275_abnormal_skin_tensile0.87257193
115MP0003879_abnormal_hair_cell0.86670098
116MP0005646_abnormal_pituitary_gland0.85941806
117MP0005379_endocrine/exocrine_gland_phen0.85428708
118MP0003936_abnormal_reproductive_system0.84212152
119MP0001286_abnormal_eye_development0.83213410
120MP0004085_abnormal_heartbeat0.82448061
121MP0001929_abnormal_gametogenesis0.81219300
122MP0008775_abnormal_heart_ventricle0.81035092
123MP0004130_abnormal_muscle_cell0.79376948
124MP0003300_gastrointestinal_ulcer0.78207347
125MP0001984_abnormal_olfaction0.77199830
126MP0001905_abnormal_dopamine_level0.76686231
127MP0003705_abnormal_hypodermis_morpholog0.74930369
128MP0002229_neurodegeneration0.73060279
129MP0004272_abnormal_basement_membrane0.72450130
130MP0005645_abnormal_hypothalamus_physiol0.72364067
131MP0003091_abnormal_cell_migration0.68054962
132MP0001943_abnormal_respiration0.67935163
133MP0003075_altered_response_to0.66680336
134MP0005388_respiratory_system_phenotype0.64552019
135MP0002133_abnormal_respiratory_system0.64552019
136MP0004742_abnormal_vestibular_system0.64117072
137MP0004233_abnormal_muscle_weight0.63853321
138MP0008874_decreased_physiological_sensi0.63484352
139MP0002069_abnormal_eating/drinking_beha0.63173459
140MP0005503_abnormal_tendon_morphology0.62811273
141MP0005535_abnormal_body_temperature0.60800594
142MP0002896_abnormal_bone_mineralization0.58020140
143MP0001963_abnormal_hearing_physiology0.57516774
144MP0001502_abnormal_circadian_rhythm0.57355854
145MP0002089_abnormal_postnatal_growth/wei0.57013002
146MP0005167_abnormal_blood-brain_barrier0.56622526
147MP0002751_abnormal_autonomic_nervous0.56441792
148MP0006054_spinal_hemorrhage0.56233461
149MP0008877_abnormal_DNA_methylation0.56015572
150MP0002090_abnormal_vision0.55841115
151MP0003861_abnormal_nervous_system0.54410080
152MP0003942_abnormal_urinary_system0.54330479
153MP0010352_gastrointestinal_tract_polyps0.54215371
154MP0004484_altered_response_of0.52416134
155MP0003121_genomic_imprinting0.52379280

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.16118379
2Termporal pattern (HP:0011008)5.03474693
3Insidious onset (HP:0003587)5.03474693
4Osteomalacia (HP:0002749)4.78749447
5Focal motor seizures (HP:0011153)4.36177035
6Action tremor (HP:0002345)4.32714035
7Focal seizures (HP:0007359)3.85834693
8Visual hallucinations (HP:0002367)3.78377537
9Stenosis of the external auditory canal (HP:0000402)3.57859482
10Ulnar claw (HP:0001178)3.37823171
11Papilledema (HP:0001085)3.37493464
12True hermaphroditism (HP:0010459)3.35978410
13Atonic seizures (HP:0010819)3.26454626
14Urinary urgency (HP:0000012)3.21647027
15Ankle clonus (HP:0011448)3.20453146
16Impaired vibration sensation in the lower limbs (HP:0002166)3.19643114
17Progressive cerebellar ataxia (HP:0002073)3.16619818
18Nephronophthisis (HP:0000090)3.14407886
19Supranuclear gaze palsy (HP:0000605)3.12419801
20Epileptic encephalopathy (HP:0200134)3.11082396
21Pheochromocytoma (HP:0002666)3.01257536
22Anomalous pulmonary venous return (HP:0010772)2.99387879
23Urinary bladder sphincter dysfunction (HP:0002839)2.98810693
24Mutism (HP:0002300)2.98347425
25Abnormality of the proximal phalanges of the hand (HP:0009834)2.97639191
26Absence seizures (HP:0002121)2.93866834
27Molar tooth sign on MRI (HP:0002419)2.82661352
28Abnormality of midbrain morphology (HP:0002418)2.82661352
29Truncal ataxia (HP:0002078)2.80514165
30Abnormality of the lower motor neuron (HP:0002366)2.77022599
31Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.75081531
32Inappropriate behavior (HP:0000719)2.74736030
33Pancreatic fibrosis (HP:0100732)2.74633736
34Male pseudohermaphroditism (HP:0000037)2.70762102
35Abnormality of the phalanges of the 5th finger (HP:0004213)2.68721949
36Septo-optic dysplasia (HP:0100842)2.67957570
37Febrile seizures (HP:0002373)2.67404288
38Generalized tonic-clonic seizures (HP:0002069)2.66773908
39Abnormality of the pulmonary veins (HP:0011718)2.66038987
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.65789330
41Neuroendocrine neoplasm (HP:0100634)2.63995893
42Abnormality of the renal collecting system (HP:0004742)2.63890623
43Short tibia (HP:0005736)2.63761120
44Abolished electroretinogram (ERG) (HP:0000550)2.62935695
45Abnormality of the middle phalanges of the toes (HP:0010183)2.60021389
46Abnormal eating behavior (HP:0100738)2.59211714
47Pancreatic cysts (HP:0001737)2.58458249
48Asplenia (HP:0001746)2.55799234
49Depression (HP:0000716)2.52890845
50Hypoplasia of the uterus (HP:0000013)2.52810137
51Abnormality of the renal medulla (HP:0100957)2.52805773
52Chronic hepatic failure (HP:0100626)2.50949698
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.50514588
54Amyotrophic lateral sclerosis (HP:0007354)2.50360303
55Resting tremor (HP:0002322)2.48598774
56Medial flaring of the eyebrow (HP:0010747)2.48048962
57Abnormality of the corticospinal tract (HP:0002492)2.47409248
58Dialeptic seizures (HP:0011146)2.45527961
59Buphthalmos (HP:0000557)2.42696536
60Disinhibition (HP:0000734)2.39551174
61Progressive inability to walk (HP:0002505)2.38837626
62Cerebral inclusion bodies (HP:0100314)2.38734585
63Neoplasm of the peripheral nervous system (HP:0100007)2.37671544
64Lower limb muscle weakness (HP:0007340)2.37448200
65Adrenal hypoplasia (HP:0000835)2.36464403
66Hammertoe (HP:0001765)2.33870451
67Megalencephaly (HP:0001355)2.33545350
68Short femoral neck (HP:0100864)2.32599725
69Fibular aplasia (HP:0002990)2.32499478
70Gait imbalance (HP:0002141)2.31406707
71Poor eye contact (HP:0000817)2.30234339
72Abnormality of renal resorption (HP:0011038)2.29642500
73Gaze-evoked nystagmus (HP:0000640)2.29508956
74Preauricular pit (HP:0004467)2.28340316
75Periauricular skin pits (HP:0100277)2.28340316
76Spastic gait (HP:0002064)2.27360552
77Hyperglycinemia (HP:0002154)2.27354768
78Segmental peripheral demyelination/remyelination (HP:0003481)2.26147862
79Postural instability (HP:0002172)2.26083229
80Abnormality of the phalanges of the 2nd finger (HP:0009541)2.25387848
81Broad-based gait (HP:0002136)2.24710952
82Decreased circulating renin level (HP:0003351)2.24572716
83Small hand (HP:0200055)2.20525685
84Akinesia (HP:0002304)2.19961504
85Aqueductal stenosis (HP:0002410)2.19918527
86Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.19091522
87Short 1st metacarpal (HP:0010034)2.19091522
88Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.18152972
89Synostosis of carpal bones (HP:0005048)2.17362711
90Apathy (HP:0000741)2.16642084
91Short 4th metacarpal (HP:0010044)2.15612153
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15612153
93Morphological abnormality of the middle ear (HP:0008609)2.14929503
94Aplasia/Hypoplasia of the fibula (HP:0006492)2.13590192
95Neurofibrillary tangles (HP:0002185)2.13333969
96Abnormality of DNA repair (HP:0003254)2.13215054
97Congenital primary aphakia (HP:0007707)2.12511062
98Torticollis (HP:0000473)2.11971328
99Pendular nystagmus (HP:0012043)2.11287013
100Excessive salivation (HP:0003781)2.10747389
101Drooling (HP:0002307)2.10747389
102Limb dystonia (HP:0002451)2.07718604
103Menstrual irregularities (HP:0000858)2.06763827
104Aplasia/hypoplasia of the uterus (HP:0008684)2.06731182
105Symphalangism affecting the phalanges of the hand (HP:0009773)2.06158260
106Short hallux (HP:0010109)2.06148455
107Impaired smooth pursuit (HP:0007772)2.06085279
108Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05662871
109Aplasia/Hypoplasia of the hallux (HP:0008362)2.03595664
110Agitation (HP:0000713)2.02906087
111Macroorchidism (HP:0000053)2.00896874
112Anxiety (HP:0000739)2.00590768
113Nephrogenic diabetes insipidus (HP:0009806)1.98542144
114Abnormality of the vocal cords (HP:0008777)1.98407567
115Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98382819
116Abnormal social behavior (HP:0012433)1.97637127
117Impaired social interactions (HP:0000735)1.97637127
118Papillary thyroid carcinoma (HP:0002895)1.97607090
119Congenital stationary night blindness (HP:0007642)1.97188232
120Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96405308
121Hypoplasia of the brainstem (HP:0002365)1.96405308
122Specific learning disability (HP:0001328)1.96347530
123Vaginal atresia (HP:0000148)1.95821009
124Genital tract atresia (HP:0001827)1.95750925
125Intention tremor (HP:0002080)1.95397514
126Diminished motivation (HP:0000745)1.95037108
127Amblyopia (HP:0000646)1.94636943
128Abnormality of the labia minora (HP:0012880)1.94057932
129Ectopic kidney (HP:0000086)1.93794107
130Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.93542756
131Stereotypic behavior (HP:0000733)1.93383631
132Thyroid carcinoma (HP:0002890)1.93147531
133Bony spicule pigmentary retinopathy (HP:0007737)1.92788847
134Abnormality of ocular smooth pursuit (HP:0000617)1.92040985
135Gait ataxia (HP:0002066)1.91784707
136Lower limb asymmetry (HP:0100559)1.91423652
137Postural tremor (HP:0002174)1.91128761
138Abnormal pancreas size (HP:0012094)1.90935652
139Asymmetry of the thorax (HP:0001555)1.90520215
140Impaired vibratory sensation (HP:0002495)1.90250244
141Pointed chin (HP:0000307)1.89863399
142Abnormality of the 4th metacarpal (HP:0010012)1.89637561
143Abnormality of pain sensation (HP:0010832)1.89531311
144Impaired pain sensation (HP:0007328)1.89531311
145Clumsiness (HP:0002312)1.89477073
146Hypoplasia of the ulna (HP:0003022)1.89363821
147Diplopia (HP:0000651)1.88475249
148Abnormality of binocular vision (HP:0011514)1.88475249
149Increased CSF protein (HP:0002922)1.88002455
150Abnormal rod and cone electroretinograms (HP:0008323)1.87222243
151Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87128786
152Abnormality of the 1st metacarpal (HP:0010009)1.87029977
153Optic nerve hypoplasia (HP:0000609)1.85484476
154Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.85429030
155Hypoplastic pelvis (HP:0008839)1.84611169
156Decreased motor nerve conduction velocity (HP:0003431)1.84316076
157Sclerocornea (HP:0000647)1.84248181
158Oligodontia (HP:0000677)1.82732212
159Dysmetria (HP:0001310)1.82289216
160Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82042387
161Degeneration of the lateral corticospinal tracts (HP:0002314)1.82042387
162Fetal akinesia sequence (HP:0001989)1.81590914
163Polyphagia (HP:0002591)1.81034871
164Dysdiadochokinesis (HP:0002075)1.80194327
165Lissencephaly (HP:0001339)1.79837726
166Rib fusion (HP:0000902)1.79059922
167Supernumerary spleens (HP:0009799)1.78788842
168Focal dystonia (HP:0004373)1.78764241
169Insomnia (HP:0100785)1.78645475
170Genetic anticipation (HP:0003743)1.78066855
171Bradykinesia (HP:0002067)1.77958053
172Hyperventilation (HP:0002883)1.77380901
173Steppage gait (HP:0003376)1.77341053
174Fibular hypoplasia (HP:0003038)1.77009072
175Abnormality of cochlea (HP:0000375)1.76953394
176Aplasia/Hypoplasia of the ulna (HP:0006495)1.76763884
177Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76435030
178Lower limb amyotrophy (HP:0007210)1.76309580
179Postaxial foot polydactyly (HP:0001830)1.76060925
180Onion bulb formation (HP:0003383)1.75787926
181Scanning speech (HP:0002168)1.75625085
182Mesomelia (HP:0003027)1.75178911
183Ankyloglossia (HP:0010296)1.75039161
184Morphological abnormality of the pyramidal tract (HP:0002062)1.73900589
185Anencephaly (HP:0002323)1.73896819
186Absent thumb (HP:0009777)1.73629267
187Chorioretinal atrophy (HP:0000533)1.72972652
188Hyperphosphatemia (HP:0002905)1.71686258
189Gonadal dysgenesis (HP:0000133)1.71404290
190Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69888612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.89778464
2NTRK33.68606057
3MAP3K93.24395841
4MINK13.15624967
5ACVR1B2.84218804
6MAP3K42.51167040
7STK392.48958923
8SCYL22.46824303
9ERBB32.37464913
10KSR22.28210535
11PLK22.19115185
12EPHA42.16885569
13CASK2.14877926
14NTRK12.13347175
15GRK12.07490153
16WNK32.02817217
17MAP2K72.01866502
18PRKD31.98903418
19CAMKK11.90686205
20KSR11.84522009
21DAPK21.83343143
22PINK11.81988808
23PAK61.80610103
24MAP3K21.78108665
25DYRK21.74789472
26ADRBK21.74361056
27NTRK21.73137735
28MAP3K121.69141681
29STK161.65079957
30TAF11.64599359
31PNCK1.63607052
32NUAK11.58566588
33PDK41.53371292
34PDK31.53371292
35MAP2K41.53054633
36PLK41.47198702
37RIPK41.47141471
38CDK51.46151095
39TLK11.44684965
40RET1.43284143
41LIMK11.37763378
42ZAK1.37562183
43LMTK21.34832511
44LATS21.32606102
45CAMKK21.28554569
46SGK4941.21918128
47SGK2231.21918128
48MAPK131.18396060
49TESK11.17078115
50DAPK11.16962708
51CDC71.16444277
52MUSK1.14004102
53SGK21.13297612
54TNIK1.11705519
55CDK141.10975004
56CSNK1G21.09884820
57PAK31.08784162
58MKNK21.03513231
59CDK181.02286062
60SGK31.01460901
61PRKCH0.97442843
62ALK0.96557960
63CSNK1A1L0.96377825
64CSNK1G10.96332555
65STK38L0.96135277
66CDK150.96105413
67PTK2B0.94056857
68FER0.93790280
69BRAF0.93270053
70EPHB20.92274219
71DYRK30.89847350
72BCR0.89187288
73PRKCG0.88345292
74NEK10.88092254
75PIK3CA0.87201309
76DYRK1A0.85950095
77FRK0.84681379
78TYRO30.83213463
79GRK50.82825625
80DDR20.81220894
81CDK190.81212626
82GRK70.81033775
83INSRR0.80918886
84PDK20.80533212
85PLK10.80415166
86PDGFRA0.79937140
87CDK11A0.77315490
88TRIM280.76399543
89TAOK30.75227951
90UHMK10.74357914
91AURKA0.73342087
92CCNB10.72166178
93NEK90.72033756
94OXSR10.71356596
95PHKG20.69017338
96PHKG10.69017338
97ARAF0.68432298
98WNK10.68101119
99PDK10.67856947
100MAP2K10.66963169
101BCKDK0.66932120
102ERBB20.66183163
103RIPK10.66080828
104* PRKACA0.65826769
105FGFR20.64661156
106BMPR20.64369043
107TRIB30.62645299
108AKT30.61790018
109SGK10.58303273
110CAMK2A0.58037197
111TIE10.57682629
112PRPF4B0.57504230
113FGFR10.56290219
114FYN0.55559898
115PRKCE0.55043508
116STK380.54210867
117VRK10.53958822
118CAMK1G0.52794517
119PDGFRB0.51710831
120SIK20.50188680
121CSNK1A10.49809565
122PKN10.48879218
123SIK30.47392779
124MAP4K20.47119423
125CAMK10.45970531
126ROCK20.45392689
127PDPK10.45222597
128PLK30.45101664
129CAMK2B0.44400214
130FES0.43691410
131STK30.43549707
132ABL20.43506621
133WEE10.43277769
134MAP3K130.43202278
135CSNK1G30.42890844
136ADRBK10.42823901
137BMPR1B0.42259821
138BRSK10.42115195
139PRKCZ0.40903728
140STK110.40606448
141ROCK10.40258935
142MAPK100.40186538
143FGFR30.39060210
144* RPS6KA30.38096217
145MAP3K10.37914071
146MARK20.37646243
147WNK40.37526277
148SRC0.37021104
149CSNK1E0.36238652
150MAPKAPK50.34265935
151PRKCI0.33918764

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.17206575
2Phototransduction_Homo sapiens_hsa047442.66194313
3Long-term potentiation_Homo sapiens_hsa047202.38105086
4Olfactory transduction_Homo sapiens_hsa047402.31956399
5Nicotine addiction_Homo sapiens_hsa050332.30457330
6Protein export_Homo sapiens_hsa030602.23650367
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.16974422
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16676387
9Oxidative phosphorylation_Homo sapiens_hsa001902.16145153
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10319869
11Circadian entrainment_Homo sapiens_hsa047132.05774062
12Dopaminergic synapse_Homo sapiens_hsa047281.99610155
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92773774
14GABAergic synapse_Homo sapiens_hsa047271.91315909
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88282750
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87886055
17Cardiac muscle contraction_Homo sapiens_hsa042601.86717690
18Amphetamine addiction_Homo sapiens_hsa050311.86238917
19Morphine addiction_Homo sapiens_hsa050321.81903597
20Parkinsons disease_Homo sapiens_hsa050121.79031353
21Glutamatergic synapse_Homo sapiens_hsa047241.78763013
22Steroid biosynthesis_Homo sapiens_hsa001001.69825395
23Gastric acid secretion_Homo sapiens_hsa049711.64384017
24Collecting duct acid secretion_Homo sapiens_hsa049661.62183595
25Fanconi anemia pathway_Homo sapiens_hsa034601.61850504
26Homologous recombination_Homo sapiens_hsa034401.60172833
27Cholinergic synapse_Homo sapiens_hsa047251.60110226
28Renin secretion_Homo sapiens_hsa049241.59984224
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59074291
30Salivary secretion_Homo sapiens_hsa049701.57526791
31Glioma_Homo sapiens_hsa052141.55018283
32Ribosome_Homo sapiens_hsa030101.54451479
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53473670
34Basal transcription factors_Homo sapiens_hsa030221.53201959
35Alzheimers disease_Homo sapiens_hsa050101.45410521
36Long-term depression_Homo sapiens_hsa047301.45121661
37Hedgehog signaling pathway_Homo sapiens_hsa043401.43846892
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42627149
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39577160
40Insulin secretion_Homo sapiens_hsa049111.37343709
41Gap junction_Homo sapiens_hsa045401.35514164
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34219708
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33359045
44Vibrio cholerae infection_Homo sapiens_hsa051101.30794687
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29548725
46Oxytocin signaling pathway_Homo sapiens_hsa049211.29088460
47Huntingtons disease_Homo sapiens_hsa050161.27808690
48Axon guidance_Homo sapiens_hsa043601.25912571
49RNA degradation_Homo sapiens_hsa030181.24577657
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22490964
51Linoleic acid metabolism_Homo sapiens_hsa005911.20552700
52Basal cell carcinoma_Homo sapiens_hsa052171.19343297
53Cocaine addiction_Homo sapiens_hsa050301.17259113
54Dorso-ventral axis formation_Homo sapiens_hsa043201.17074371
55Estrogen signaling pathway_Homo sapiens_hsa049151.16771310
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.16183678
57Serotonergic synapse_Homo sapiens_hsa047261.15169859
58Oocyte meiosis_Homo sapiens_hsa041141.15074780
59ErbB signaling pathway_Homo sapiens_hsa040121.14313874
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13504399
61GnRH signaling pathway_Homo sapiens_hsa049121.13433583
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13096334
63Retinol metabolism_Homo sapiens_hsa008301.13037186
64Taste transduction_Homo sapiens_hsa047421.12956268
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11270755
66Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10485145
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06678537
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05147668
69Selenocompound metabolism_Homo sapiens_hsa004501.03159497
70Endometrial cancer_Homo sapiens_hsa052131.02763490
71Calcium signaling pathway_Homo sapiens_hsa040201.02300502
72Phagosome_Homo sapiens_hsa041451.02052104
73Propanoate metabolism_Homo sapiens_hsa006401.00033768
74Tryptophan metabolism_Homo sapiens_hsa003800.98185273
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97538486
76cAMP signaling pathway_Homo sapiens_hsa040240.95657967
77Nucleotide excision repair_Homo sapiens_hsa034200.95515618
78Type II diabetes mellitus_Homo sapiens_hsa049300.95186793
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95151646
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.94905063
81Hippo signaling pathway_Homo sapiens_hsa043900.93530244
82Chemical carcinogenesis_Homo sapiens_hsa052040.92688650
83RNA polymerase_Homo sapiens_hsa030200.92561186
84Melanogenesis_Homo sapiens_hsa049160.90594805
85Endocytosis_Homo sapiens_hsa041440.89778109
86mTOR signaling pathway_Homo sapiens_hsa041500.89494245
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88904057
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.87046637
89Butanoate metabolism_Homo sapiens_hsa006500.86188103
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84178498
91Non-small cell lung cancer_Homo sapiens_hsa052230.83786188
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.83782403
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83510329
94Colorectal cancer_Homo sapiens_hsa052100.82856936
95Peroxisome_Homo sapiens_hsa041460.82744954
96Thyroid hormone synthesis_Homo sapiens_hsa049180.82137282
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81039814
98VEGF signaling pathway_Homo sapiens_hsa043700.80786733
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80685525
100Alcoholism_Homo sapiens_hsa050340.78430744
101Type I diabetes mellitus_Homo sapiens_hsa049400.77744597
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.77427757
103Renal cell carcinoma_Homo sapiens_hsa052110.76856677
104Ether lipid metabolism_Homo sapiens_hsa005650.76719969
105Wnt signaling pathway_Homo sapiens_hsa043100.76049674
106Regulation of autophagy_Homo sapiens_hsa041400.75952748
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75613133
108Rap1 signaling pathway_Homo sapiens_hsa040150.74041734
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73351067
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72358130
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72065580
112MAPK signaling pathway_Homo sapiens_hsa040100.71593610
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70818931
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69001205
115Melanoma_Homo sapiens_hsa052180.65839230
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65456069
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65062114
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64748461
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64401725
120Glycerolipid metabolism_Homo sapiens_hsa005610.63886657
121Proteoglycans in cancer_Homo sapiens_hsa052050.63001766
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.62999886
123Ras signaling pathway_Homo sapiens_hsa040140.62669674
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62277879
125Vitamin digestion and absorption_Homo sapiens_hsa049770.61679473
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60372087
127Salmonella infection_Homo sapiens_hsa051320.60291529
128beta-Alanine metabolism_Homo sapiens_hsa004100.60151351
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59980890
130Tuberculosis_Homo sapiens_hsa051520.59872787
131Pancreatic cancer_Homo sapiens_hsa052120.59054049
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58581201
133Nitrogen metabolism_Homo sapiens_hsa009100.58207164
134TGF-beta signaling pathway_Homo sapiens_hsa043500.57809243
135Focal adhesion_Homo sapiens_hsa045100.57398854
136Chemokine signaling pathway_Homo sapiens_hsa040620.57026936
137Platelet activation_Homo sapiens_hsa046110.56065608
138Rheumatoid arthritis_Homo sapiens_hsa053230.55967994
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55723363
140Prion diseases_Homo sapiens_hsa050200.54808780
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54667599
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54550953
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53985653
144Choline metabolism in cancer_Homo sapiens_hsa052310.53915318
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53553910
146Insulin signaling pathway_Homo sapiens_hsa049100.53154616
147Tight junction_Homo sapiens_hsa045300.53128143
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.52216758
149Mismatch repair_Homo sapiens_hsa034300.51044639
150Glucagon signaling pathway_Homo sapiens_hsa049220.50987426
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50895233
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50799479
153Amoebiasis_Homo sapiens_hsa051460.49154442
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49065954
155Sulfur relay system_Homo sapiens_hsa041220.48889709
156Fatty acid elongation_Homo sapiens_hsa000620.46972051
157Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46745279
158Caffeine metabolism_Homo sapiens_hsa002320.44398838
159Cysteine and methionine metabolism_Homo sapiens_hsa002700.40727260

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